Genomes and Genes
Gene Symbol: Nrx-1
Description: Neurexin 1
Alias: CG7050, CT21808, Dmel\CG7050, Nrx, Nrx1, dnrx, dnrx-1, dnrx1, nrx, CG7050-PA, CG7050-PB, CG7050-PC, CG7050-PD, CG7050-PE, CG7050-PF, CG7050-PG, CG7050-PH, CG7050-PI, Neurexin-1, Neurexin-like, Nrx-1-PA, Nrx-1-PB, Nrx-1-PC, Nrx-1-PD, Nrx-1-PE, Nrx-1-PF, Nrx-1-PG, Nrx-1-PH, Nrx-1-PI, drosophila neurexin, neurexin, neurexin 1
Species: fruit fly
- Towards a membrane proteome in Drosophila: a method for the isolation of plasma membraneMansi R Khanna
Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
BMC Genomics 11:302. 2010..To facilitate genetic investigation of activities contributing to the content of the PM sub-proteome, we sought to adapt 2PAP to this invertebrate model to provide a robust PM isolation technique for Drosophila...
- Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junctionMingkuan Sun
The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, China
J Neurosci 31:687-99. 2011..Finally, we show that dnl2 colocalizes and binds to Drosophila neurexin (dnrx) in vivo...
- Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctionsDaniel Banovic
University of Munster, Institute for Neurobiology, Munster, Germany
Neuron 66:724-38. 2010..Formation of these clusters depends on presynaptic Drosophila Neurexin (DNrx). However, DNrx binding is not an absolute requirement for DNlg1 function...
- Neurexin in embryonic Drosophila neuromuscular junctionsKaiyun Chen
Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America
PLoS ONE 5:e11115. 2010..Previous studies have described Drosophila neurexin mutant phenotypes in third instar larvae and adults...
- Neurexin-1 is required for synapse formation and larvae associative learning in DrosophilaXiankun Zeng
Department of Genetics and Developmental Biology, Genetics Research Center, Southeast University Medical School, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China
FEBS Lett 581:2509-16. 2007..Here, we report for the first time that Drosophila neurexin is required for synapse formation and associative learning in larvae...
- Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmissionJingjun Li
Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
Neuron 55:741-55. 2007..Here, we have obtained null mutations in the single Drosophila neurexin gene (dnrx)...
- Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assemblyDavid Owald
Freie Universitat Berlin, Institute for Biology Genetics, Berlin, Germany
Nat Neurosci 15:1219-26. 2012..Synapse formation and maturation requires bidirectional communication across the synaptic cleft. The trans-synaptic Neurexin-Neuroligin complex can bridge this cleft, and severe synapse assembly deficits are found in Drosophila ..
- Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJAndre Koper
Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester, United Kingdom
PLoS ONE 7:e36339. 2012..Therefore, future developmental studies of these synaptic junctions in Drosophila need to consider the important contribution made by BM-dependent mechanisms, in addition to CAM-dependent adhesion...
- CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in DrosophilaChristiane Zweier
Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
Am J Hum Genet 85:655-66. 2009Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental language ..
- Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junctionMingkuan Sun
Department of Genetics and Developmental Biology, Southeast University Medical School, The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, China
Neurosci Res 64:362-71. 2009..Recent genetic studies using Drosophila melanogaster have implicated an essential role for a single Drosophila neurexin (dnrx) in the proper architecture, development and function of synapses in vivo...
- Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila tracheaShenqiu Wang
Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Arrhenius Labs E3, S 10691 Stockholm, Sweden
Curr Biol 16:180-5. 2006..We propose that the subsequent structural modification of chitin by chitin binding deacetylases selectively instructs the termination of tube elongation to the underlying epithelium...
- Adhesion proteins and the control of cell shapeRichard W Carthew
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
Curr Opin Genet Dev 15:358-63. 2005..Recent insights into adherens junction remodeling have revealed the importance of polarized localization of myosin and Par3 at the adherens junction...
- Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartmentBill Adolfsen
The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
J Cell Biol 166:249-60. 2004..In addition, the identification of a postsynaptic synaptotagmin suggests calcium-dependent membrane-trafficking functions on both sides of the synapse...
- Discs-Large and Strabismus are functionally linked to plasma membrane formationOk kyung Lee
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Nat Cell Biol 5:987-93. 2003..This effect was dependent on the interaction between Stbm and SAP97. These findings suggest that the Dlg-Stbm complex recruits membrane-associated proteins and lipids from internal membranes to sites of new plasma membrane formation...
- Structure and evolution of neurexin genes: insight into the mechanism of alternative splicingKatsuhiko Tabuchi
Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Genomics 79:849-59. 2002..We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from ..
- PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTIONRichard Carthew; Fiscal Year: 2005..abstract_text> ..