Nrx-1

Summary

Gene Symbol: Nrx-1
Description: Neurexin 1
Alias: CG7050, CT21808, DNrx, Dmel\CG7050, Nrx, Nrx1, dnrx, dnrx-1, dnrx1, nrx, nrx-1, CG7050 gene product from transcript CG7050-RA, CG7050-PA, CG7050-PB, CG7050-PC, CG7050-PD, CG7050-PE, CG7050-PF, CG7050-PG, CG7050-PH, CG7050-PI, Neurexin-1, Neurexin-like, Nrx-1-PA, Nrx-1-PB, Nrx-1-PC, Nrx-1-PD, Nrx-1-PE, Nrx-1-PF, Nrx-1-PG, Nrx-1-PH, Nrx-1-PI, drosophila neurexin, neurexin, neurexin 1
Species: fruit fly

Top Publications

  1. pmc Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane
    Mansi R Khanna
    Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 11:302. 2010
  2. ncbi Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila trachea
    Shenqiu Wang
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Arrhenius Labs E3, S 10691 Stockholm, Sweden
    Curr Biol 16:180-5. 2006
  3. ncbi Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
    Xiankun Zeng
    Department of Genetics and Developmental Biology, Genetics Research Center, Southeast University Medical School, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China
    FEBS Lett 581:2509-16. 2007
  4. pmc Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission
    Jingjun Li
    Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    Neuron 55:741-55. 2007
  5. pmc CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila
    Christiane Zweier
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:655-66. 2009
  6. doi Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions
    Daniel Banovic
    University of Munster, Institute for Neurobiology, Munster, Germany
    Neuron 66:724-38. 2010
  7. pmc Neurexin in embryonic Drosophila neuromuscular junctions
    Kaiyun Chen
    Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e11115. 2010
  8. doi Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction
    Mingkuan Sun
    The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, China
    J Neurosci 31:687-99. 2011
  9. pmc The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression
    Tao Li
    From the Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096 and
    J Biol Chem 290:17656-67. 2015
  10. pmc Drosophila neuroligin3 regulates neuromuscular junction development and synaptic differentiation
    Guanglin Xing
    From the Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing 210096, China
    J Biol Chem 289:31867-77. 2014

Research Grants

Scientific Experts

  • Brian A Mozer
  • Swati Banerjee
  • Mingkuan Sun
  • Richard Carthew
  • Wei Xie
  • Tao Li
  • Junhai Han
  • Yao Tian
  • Stephan J Sigrist
  • J Troy Littleton
  • David Owald
  • Daniel Banovic
  • Manzoor A Bhat
  • Jingjun Li
  • Mikolaj J Sulkowski
  • Kathryn P Harris
  • Aoife Larkin
  • Timothy J Mosca
  • Karzan Muhammad
  • Huihui Lv
  • Qian Li
  • Guanglin Xing
  • Suzanne M McDermott
  • Aline D Blunk
  • Harald Depner
  • Pu Fan
  • Yu Chi Chen
  • Andre Koper
  • Wangsun Choi
  • Omid Khorramshahi
  • Wernher Fouquet
  • Irmgard U Haussmann
  • Hermann Aberle
  • Carolin Wichmann
  • Annette Schenck
  • Mansi R Khanna
  • Kaiyun Chen
  • Christiane Zweier
  • Xiankun Zeng
  • Shenqiu Wang
  • Bill Adolfsen
  • Tae Hee Han
  • Ok kyung Lee
  • Yao V Zhang
  • Esther M Verheyen
  • Carolyn Ott
  • Norbert Perrimon
  • Zachary D Piccioli
  • Jennifer Lippincott-Schwartz
  • Qi Wang
  • Mihaela Serpe
  • Peter Scheiffele
  • Fabian Goettfert
  • Mathias A Böhme
  • Jan Schmoranzer
  • Dietmar Schreiner
  • Janine Lützkendorf
  • Charles Claudianos
  • Ming Yu Chen
  • Judith Reinhard
  • Niraja Ramesh
  • Dominique D Bergeron
  • Bernhard Loll
  • Leonie Kirszenblat
  • Bruno van Swinderen
  • Ulises Rey
  • Huiying Chen
  • Jan H Driller
  • Markus C Wahl
  • Mathew Holt
  • Christina Hollmann
  • Tanja Matkovic
  • Torsten Götz
  • Stefan W Hell
  • Suneel Reddy-Alla
  • Alexander M Walter
  • James M Halstead
  • Ke Xu
  • Katsuhiko Tabuchi
  • Lu Yang
  • Jihye Lee
  • Guangming Gan
  • Uwe Walldorf
  • Xiaowei Zhuang
  • Russell S Hamilton
  • Yulia Akbergenova
  • Carine Meignin
  • Ilan Davis
  • Guisheng Zhong
  • Richard W Cho

Detail Information

Publications32

  1. pmc Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane
    Mansi R Khanna
    Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 11:302. 2010
    ..To facilitate genetic investigation of activities contributing to the content of the PM sub-proteome, we sought to adapt 2PAP to this invertebrate model to provide a robust PM isolation technique for Drosophila...
  2. ncbi Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila trachea
    Shenqiu Wang
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Arrhenius Labs E3, S 10691 Stockholm, Sweden
    Curr Biol 16:180-5. 2006
    ..We propose that the subsequent structural modification of chitin by chitin binding deacetylases selectively instructs the termination of tube elongation to the underlying epithelium...
  3. ncbi Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
    Xiankun Zeng
    Department of Genetics and Developmental Biology, Genetics Research Center, Southeast University Medical School, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China
    FEBS Lett 581:2509-16. 2007
    ..Here, we report for the first time that Drosophila neurexin is required for synapse formation and associative learning in larvae...
  4. pmc Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission
    Jingjun Li
    Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    Neuron 55:741-55. 2007
    ..Here, we have obtained null mutations in the single Drosophila neurexin gene (dnrx)...
  5. pmc CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila
    Christiane Zweier
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:655-66. 2009
    Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental language ..
  6. doi Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions
    Daniel Banovic
    University of Munster, Institute for Neurobiology, Munster, Germany
    Neuron 66:724-38. 2010
    ..Formation of these clusters depends on presynaptic Drosophila Neurexin (DNrx). However, DNrx binding is not an absolute requirement for DNlg1 function...
  7. pmc Neurexin in embryonic Drosophila neuromuscular junctions
    Kaiyun Chen
    Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e11115. 2010
    ..Previous studies have described Drosophila neurexin mutant phenotypes in third instar larvae and adults...
  8. doi Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction
    Mingkuan Sun
    The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, China
    J Neurosci 31:687-99. 2011
    ..Finally, we show that dnl2 colocalizes and binds to Drosophila neurexin (dnrx) in vivo...
  9. pmc The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression
    Tao Li
    From the Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096 and
    J Biol Chem 290:17656-67. 2015
    ..Here, we show that nrx mutant synapses exhibit rapid short term synaptic depression upon tetanic nerve stimulation...
  10. pmc Drosophila neuroligin3 regulates neuromuscular junction development and synaptic differentiation
    Guanglin Xing
    From the Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing 210096, China
    J Biol Chem 289:31867-77. 2014
    ..Altogether, our data showed that DNlg3 was required for NMJ development, synaptic differentiation, and function. ..
  11. pmc Drosophila Syncrip modulates the expression of mRNAs encoding key synaptic proteins required for morphology at the neuromuscular junction
    Suzanne M McDermott
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    RNA 20:1593-606. 2014
    ..associates with a number of mRNAs encoding proteins with key synaptic functions, including msp-300, syd-1, neurexin-1, futsch, highwire, discs large, and α-spectrin...
  12. pmc Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction
    Aline D Blunk
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, United States Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
    Mol Cell Neurosci 61:241-54. 2014
    ..Genetic interactions between act(E84K) and neurexin mutants suggest that the postsynaptic actin cytoskeleton may function together with the Neurexin-Neuroligin ..
  13. pmc Genetic and neural mechanisms that inhibit Drosophila from mating with other species
    Pu Fan
    State Key Laboratory of Biomembrane and Membrane Biology, School of Life Sciences, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    Cell 154:89-102. 2013
    ..Although this chemosensory pathway does not inhibit interspecies mating in D. melanogaster females, similar mechanisms appear to inhibit this behavior in many other male drosophilids...
  14. doi Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation
    Yao Tian
    Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China
    Neuron 77:311-22. 2013
    Neurexins are cell adhesion molecules involved in synapse formation and synaptic regulation. Mutations in the neurexin genes are linked to a number of neurodevelopmental disorders such as autism...
  15. pmc Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission
    Yu Chi Chen
    Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
    J Neurosci 32:16018-30. 2012
    ..results provide compelling evidence that Dnlg2 functions both presynaptically and postsynaptically together with Neurexin to determine the proper number of boutons as well as the number of AZs and size of synaptic densities during the ..
  16. pmc Drosophila neuroligin 1 regulates synaptic growth and function in response to activity and phosphoinositide-3-kinase
    Brian A Mozer
    Laboratory of Biochemical Genetics, National Institute of Heart, Lung and Blood, NIH, Bethesda, MD 20892, USA
    Mol Cell Neurosci 51:89-100. 2012
    ..Overgrowth and reduced EJC amplitude required Drosophila neurexin 1 (dnrx1) function, suggesting that increased DNlg1/DNrx1 signaling attenuates synaptic transmission and ..
  17. pmc On the Teneurin track: a new synaptic organization molecule emerges
    Timothy J Mosca
    Department of Biology, Stanford University Stanford, CA, USA
    Front Cell Neurosci 9:204. 2015
    ..This review will examine the Teneurins as synaptic cell adhesion molecules, explore how they regulate synaptic organization, and consider how some consequences of human Teneurin mutations may have synaptopathic origins. ..
  18. doi Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogaster
    Aoife Larkin
    Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia
    Eur J Neurosci 42:2455-66. 2015
    ..We examined the effects of neurexin-1 perturbation on sleep in Drosophila, showing that neurexin-1 nulls displayed fragmented sleep and altered ..
  19. pmc ELAV-mediated 3'-end processing of ewg transcripts is evolutionarily conserved despite sequence degeneration of the ELAV-binding site
    Irmgard U Haussmann
    School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Genetics 189:97-107. 2011
    ..melanogaster is sufficient for ELAV recruitment in vivo. Hence, our data suggest that ELAV/Hu protein-regulated alternative RNA processing is more conserved than anticipated from the alignment of degenerate low-complexity sequences...
  20. pmc The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
    Wangsun Choi
    Department of Biology, University of North Carolina at Chapel Hill, USA
    Mol Biol Cell 22:2010-30. 2011
    ..Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure...
  21. pmc Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function
    Karzan Muhammad
    Freie Universitat Berlin, Institute for Biology Genetics, Takustrasse 6, Berlin 14195, Germany
    Nat Commun 6:8362. 2015
    Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin...
  22. doi Temporal and spatial expression of Drosophila Neurexin during the life cycle visualized using a DNRX-Gal4/UAS-reporter
    Mingkuan Sun
    The Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, 210096, China
    Sci China Life Sci 59:68-77. 2016
    b>Drosophila neurexin (DNRX) plays a critical role in proper architecture development and synaptic function in vivo. However, the temporal and spatial expression pattern of DNRX still remains unclear...
  23. pmc A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction
    Mikolaj J Sulkowski
    Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, Maryland, United States of America
    PLoS Genet 12:e1005810. 2016
    ..Thus, BMP pathway may monitor synapse activity then function to adjust synapse growth and maturation during development. ..
  24. pmc The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling
    Kathryn P Harris
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States
    elife 5:. 2016
    ..Our findings suggest a conserved postsynaptic SNARE machinery controls multiple aspects of retrograde signaling and cargo trafficking within the postsynaptic compartment. ..
  25. pmc Neurexin, Neuroligin and Wishful Thinking coordinate synaptic cytoarchitecture and growth at neuromuscular junctions
    Swati Banerjee
    Department of Cellular and Integrative Physiology, School of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA Electronic address
    Mol Cell Neurosci 78:9-24. 2016
    ..In Drosophila, while Neurexin (Dnrx) and Neuroligins (Dnlg) are emerging as central organizing molecules at synapses, very little is known of ..
  26. doi Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly
    David Owald
    Freie Universitat Berlin, Institute for Biology Genetics, Berlin, Germany
    Nat Neurosci 15:1219-26. 2012
    ..Synapse formation and maturation requires bidirectional communication across the synaptic cleft. The trans-synaptic Neurexin-Neuroligin complex can bridge this cleft, and severe synapse assembly deficits are found in Drosophila ..
  27. pmc Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJ
    Andre Koper
    Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester, United Kingdom
    PLoS ONE 7:e36339. 2012
    ..Therefore, future developmental studies of these synaptic junctions in Drosophila need to consider the important contribution made by BM-dependent mechanisms, in addition to CAM-dependent adhesion...
  28. ncbi Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing
    Katsuhiko Tabuchi
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Genomics 79:849-59. 2002
    ..We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from ..
  29. doi Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junction
    Mingkuan Sun
    Department of Genetics and Developmental Biology, Southeast University Medical School, The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, China
    Neurosci Res 64:362-71. 2009
    ..Recent genetic studies using Drosophila melanogaster have implicated an essential role for a single Drosophila neurexin (dnrx) in the proper architecture, development and function of synapses in vivo...
  30. ncbi Adhesion proteins and the control of cell shape
    Richard W Carthew
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
    Curr Opin Genet Dev 15:358-63. 2005
    ..Recent insights into adherens junction remodeling have revealed the importance of polarized localization of myosin and Par3 at the adherens junction...
  31. pmc Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
    Bill Adolfsen
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 166:249-60. 2004
    ..In addition, the identification of a postsynaptic synaptotagmin suggests calcium-dependent membrane-trafficking functions on both sides of the synapse...
  32. pmc Discs-Large and Strabismus are functionally linked to plasma membrane formation
    Ok kyung Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nat Cell Biol 5:987-93. 2003
    ..This effect was dependent on the interaction between Stbm and SAP97. These findings suggest that the Dlg-Stbm complex recruits membrane-associated proteins and lipids from internal membranes to sites of new plasma membrane formation...

Research Grants1

  1. PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTION
    Richard Carthew; Fiscal Year: 2005
    ..abstract_text> ..