Nrx-1

Summary

Gene Symbol: Nrx-1
Description: Neurexin 1
Alias: CG7050, CT21808, Dmel\CG7050, Nrx, Nrx1, dnrx, dnrx-1, dnrx1, nrx, CG7050-PA, CG7050-PB, CG7050-PC, CG7050-PD, CG7050-PE, CG7050-PF, CG7050-PG, CG7050-PH, CG7050-PI, Neurexin-1, Neurexin-like, Nrx-1-PA, Nrx-1-PB, Nrx-1-PC, Nrx-1-PD, Nrx-1-PE, Nrx-1-PF, Nrx-1-PG, Nrx-1-PH, Nrx-1-PI, drosophila neurexin, neurexin, neurexin 1
Species: fruit fly

Top Publications

  1. pmc Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane
    Mansi R Khanna
    Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 11:302. 2010
  2. doi Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction
    Mingkuan Sun
    The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, China
    J Neurosci 31:687-99. 2011
  3. doi Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions
    Daniel Banovic
    University of Munster, Institute for Neurobiology, Munster, Germany
    Neuron 66:724-38. 2010
  4. pmc Neurexin in embryonic Drosophila neuromuscular junctions
    Kaiyun Chen
    Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e11115. 2010
  5. ncbi Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
    Xiankun Zeng
    Department of Genetics and Developmental Biology, Genetics Research Center, Southeast University Medical School, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China
    FEBS Lett 581:2509-16. 2007
  6. pmc Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission
    Jingjun Li
    Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    Neuron 55:741-55. 2007
  7. doi Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly
    David Owald
    Freie Universitat Berlin, Institute for Biology Genetics, Berlin, Germany
    Nat Neurosci 15:1219-26. 2012
  8. pmc Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJ
    Andre Koper
    Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester, United Kingdom
    PLoS ONE 7:e36339. 2012
  9. pmc CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila
    Christiane Zweier
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:655-66. 2009
  10. doi Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junction
    Mingkuan Sun
    Department of Genetics and Developmental Biology, Southeast University Medical School, The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, China
    Neurosci Res 64:362-71. 2009

Research Grants

Scientific Experts

  • Richard Carthew
  • Mingkuan Sun
  • Xiankun Zeng
  • David Owald
  • Daniel Banovic
  • Wei Xie
  • Andre Koper
  • Stephan J Sigrist
  • Wernher Fouquet
  • Hermann Aberle
  • Omid Khorramshahi
  • Carolin Wichmann
  • Annette Schenck
  • Kaiyun Chen
  • Ming Fang
  • Mansi R Khanna
  • Christiane Zweier
  • Li Liu
  • Jingjun Li
  • Shenqiu Wang
  • Bill Adolfsen
  • Ok kyung Lee
  • Katsuhiko Tabuchi
  • Andreas Prokop
  • Varun K Gupta
  • Harald Depner
  • Eric Reynolds
  • Stefan Eimer
  • Matthew Holt
  • Sara Mertel
  • Junhai Han
  • Gabrielle L Boulianne
  • Guanglin Xing
  • Guangming Gan
  • Cui He
  • David Knight
  • Sheila Irene With
  • Liudi Yuan
  • Szi Chieh Yu
  • Elena O Gracheva
  • Rui Tian
  • Tamara Riedt
  • Bruce A Stanley
  • Graham H Thomas
  • David E Featherstone
  • Janet Richmond
  • Qi Sheng
  • Eiko K de Jong
  • Lilian B Ousager
  • Merel A W Oortveld
  • Emilia K Bijlsma
  • Alfredo Orrico
  • Min Xu
  • Lijuan Liu
  • Anita Rauch
  • Andre Reis
  • Markus Zweier
  • Arif B Ekici
  • Amanda L Collins
  • Manzoor A Bhat
  • James Ashley
  • Liuchan Wei
  • Vivian Budnik
  • Fading Chen
  • Haining Jin
  • Vasilios Tsarouhas
  • Kirsten André Senti
  • Christos Samakovlis
  • Johanna Hemphälä
  • Satish Arcot Jayaram
  • J Troy Littleton
  • Sudipta Saraswati
  • Motojiro Yoshihara
  • Ronald T Javier
  • Kyung Ok Cho
  • Zhi Hong Chen
  • Kristopher K Frese
  • Jennifer S James
  • Darshana Chadda
  • Thomas C Sudhof

Detail Information

Publications15

  1. pmc Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane
    Mansi R Khanna
    Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Genomics 11:302. 2010
    ..To facilitate genetic investigation of activities contributing to the content of the PM sub-proteome, we sought to adapt 2PAP to this invertebrate model to provide a robust PM isolation technique for Drosophila...
  2. doi Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction
    Mingkuan Sun
    The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, China
    J Neurosci 31:687-99. 2011
    ..Finally, we show that dnl2 colocalizes and binds to Drosophila neurexin (dnrx) in vivo...
  3. doi Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions
    Daniel Banovic
    University of Munster, Institute for Neurobiology, Munster, Germany
    Neuron 66:724-38. 2010
    ..Formation of these clusters depends on presynaptic Drosophila Neurexin (DNrx). However, DNrx binding is not an absolute requirement for DNlg1 function...
  4. pmc Neurexin in embryonic Drosophila neuromuscular junctions
    Kaiyun Chen
    Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 5:e11115. 2010
    ..Previous studies have described Drosophila neurexin mutant phenotypes in third instar larvae and adults...
  5. ncbi Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
    Xiankun Zeng
    Department of Genetics and Developmental Biology, Genetics Research Center, Southeast University Medical School, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China
    FEBS Lett 581:2509-16. 2007
    ..Here, we report for the first time that Drosophila neurexin is required for synapse formation and associative learning in larvae...
  6. pmc Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission
    Jingjun Li
    Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    Neuron 55:741-55. 2007
    ..Here, we have obtained null mutations in the single Drosophila neurexin gene (dnrx)...
  7. doi Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly
    David Owald
    Freie Universitat Berlin, Institute for Biology Genetics, Berlin, Germany
    Nat Neurosci 15:1219-26. 2012
    ..Synapse formation and maturation requires bidirectional communication across the synaptic cleft. The trans-synaptic Neurexin-Neuroligin complex can bridge this cleft, and severe synapse assembly deficits are found in Drosophila ..
  8. pmc Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJ
    Andre Koper
    Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester, United Kingdom
    PLoS ONE 7:e36339. 2012
    ..Therefore, future developmental studies of these synaptic junctions in Drosophila need to consider the important contribution made by BM-dependent mechanisms, in addition to CAM-dependent adhesion...
  9. pmc CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila
    Christiane Zweier
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:655-66. 2009
    Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental language ..
  10. doi Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junction
    Mingkuan Sun
    Department of Genetics and Developmental Biology, Southeast University Medical School, The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, China
    Neurosci Res 64:362-71. 2009
    ..Recent genetic studies using Drosophila melanogaster have implicated an essential role for a single Drosophila neurexin (dnrx) in the proper architecture, development and function of synapses in vivo...
  11. ncbi Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila trachea
    Shenqiu Wang
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Arrhenius Labs E3, S 10691 Stockholm, Sweden
    Curr Biol 16:180-5. 2006
    ..We propose that the subsequent structural modification of chitin by chitin binding deacetylases selectively instructs the termination of tube elongation to the underlying epithelium...
  12. ncbi Adhesion proteins and the control of cell shape
    Richard W Carthew
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
    Curr Opin Genet Dev 15:358-63. 2005
    ..Recent insights into adherens junction remodeling have revealed the importance of polarized localization of myosin and Par3 at the adherens junction...
  13. pmc Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
    Bill Adolfsen
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 166:249-60. 2004
    ..In addition, the identification of a postsynaptic synaptotagmin suggests calcium-dependent membrane-trafficking functions on both sides of the synapse...
  14. pmc Discs-Large and Strabismus are functionally linked to plasma membrane formation
    Ok kyung Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nat Cell Biol 5:987-93. 2003
    ..This effect was dependent on the interaction between Stbm and SAP97. These findings suggest that the Dlg-Stbm complex recruits membrane-associated proteins and lipids from internal membranes to sites of new plasma membrane formation...
  15. ncbi Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing
    Katsuhiko Tabuchi
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Genomics 79:849-59. 2002
    ..We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from ..

Research Grants1

  1. PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTION
    Richard Carthew; Fiscal Year: 2005
    ..abstract_text> ..