Genomes and Genes
Gene Symbol: Nrx-1
Description: Neurexin 1
Alias: CG7050, CT21808, DNrx, Dmel\CG7050, Nrx, Nrx1, dnrx, dnrx-1, dnrx1, nrx, nrx-1, CG7050 gene product from transcript CG7050-RA, CG7050-PA, CG7050-PB, CG7050-PC, CG7050-PD, CG7050-PE, CG7050-PF, CG7050-PG, CG7050-PH, CG7050-PI, Neurexin-1, Neurexin-like, Nrx-1-PA, Nrx-1-PB, Nrx-1-PC, Nrx-1-PD, Nrx-1-PE, Nrx-1-PF, Nrx-1-PG, Nrx-1-PH, Nrx-1-PI, drosophila neurexin, neurexin, neurexin 1
Species: fruit fly
- Towards a membrane proteome in Drosophila: a method for the isolation of plasma membraneMansi R Khanna
Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
BMC Genomics 11:302. 2010..To facilitate genetic investigation of activities contributing to the content of the PM sub-proteome, we sought to adapt 2PAP to this invertebrate model to provide a robust PM isolation technique for Drosophila...
- Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila tracheaShenqiu Wang
Department of Developmental Biology, Wenner Gren Institute, Stockholm University, Arrhenius Labs E3, S 10691 Stockholm, Sweden
Curr Biol 16:180-5. 2006..We propose that the subsequent structural modification of chitin by chitin binding deacetylases selectively instructs the termination of tube elongation to the underlying epithelium...
- Neurexin-1 is required for synapse formation and larvae associative learning in DrosophilaXiankun Zeng
Department of Genetics and Developmental Biology, Genetics Research Center, Southeast University Medical School, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China
FEBS Lett 581:2509-16. 2007..Here, we report for the first time that Drosophila neurexin is required for synapse formation and associative learning in larvae...
- Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmissionJingjun Li
Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
Neuron 55:741-55. 2007..Here, we have obtained null mutations in the single Drosophila neurexin gene (dnrx)...
- CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in DrosophilaChristiane Zweier
Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
Am J Hum Genet 85:655-66. 2009Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental language ..
- Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctionsDaniel Banovic
University of Munster, Institute for Neurobiology, Munster, Germany
Neuron 66:724-38. 2010..Formation of these clusters depends on presynaptic Drosophila Neurexin (DNrx). However, DNrx binding is not an absolute requirement for DNlg1 function...
- Neurexin in embryonic Drosophila neuromuscular junctionsKaiyun Chen
Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America
PLoS ONE 5:e11115. 2010..Previous studies have described Drosophila neurexin mutant phenotypes in third instar larvae and adults...
- Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junctionMingkuan Sun
The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, China
J Neurosci 31:687-99. 2011..Finally, we show that dnl2 colocalizes and binds to Drosophila neurexin (dnrx) in vivo...
- The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic DepressionTao Li
From the Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096 and
J Biol Chem 290:17656-67. 2015..Here, we show that nrx mutant synapses exhibit rapid short term synaptic depression upon tetanic nerve stimulation...
- Drosophila neuroligin3 regulates neuromuscular junction development and synaptic differentiationGuanglin Xing
From the Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing 210096, China
J Biol Chem 289:31867-77. 2014..Altogether, our data showed that DNlg3 was required for NMJ development, synaptic differentiation, and function. ..
- Drosophila Syncrip modulates the expression of mRNAs encoding key synaptic proteins required for morphology at the neuromuscular junctionSuzanne M McDermott
Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
RNA 20:1593-606. 2014..associates with a number of mRNAs encoding proteins with key synaptic functions, including msp-300, syd-1, neurexin-1, futsch, highwire, discs large, and α-spectrin...
- Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junctionAline D Blunk
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, United States Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
Mol Cell Neurosci 61:241-54. 2014..Genetic interactions between act(E84K) and neurexin mutants suggest that the postsynaptic actin cytoskeleton may function together with the Neurexin-Neuroligin ..
- Genetic and neural mechanisms that inhibit Drosophila from mating with other speciesPu Fan
State Key Laboratory of Biomembrane and Membrane Biology, School of Life Sciences, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Cell 154:89-102. 2013..Although this chemosensory pathway does not inhibit interspecies mating in D. melanogaster females, similar mechanisms appear to inhibit this behavior in many other male drosophilids...
- Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturationYao Tian
Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China
Neuron 77:311-22. 2013Neurexins are cell adhesion molecules involved in synapse formation and synaptic regulation. Mutations in the neurexin genes are linked to a number of neurodevelopmental disorders such as autism...
- Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmissionYu Chi Chen
Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7545, USA
J Neurosci 32:16018-30. 2012..results provide compelling evidence that Dnlg2 functions both presynaptically and postsynaptically together with Neurexin to determine the proper number of boutons as well as the number of AZs and size of synaptic densities during the ..
- Drosophila neuroligin 1 regulates synaptic growth and function in response to activity and phosphoinositide-3-kinaseBrian A Mozer
Laboratory of Biochemical Genetics, National Institute of Heart, Lung and Blood, NIH, Bethesda, MD 20892, USA
Mol Cell Neurosci 51:89-100. 2012..Overgrowth and reduced EJC amplitude required Drosophila neurexin 1 (dnrx1) function, suggesting that increased DNlg1/DNrx1 signaling attenuates synaptic transmission and ..
- On the Teneurin track: a new synaptic organization molecule emergesTimothy J Mosca
Department of Biology, Stanford University Stanford, CA, USA
Front Cell Neurosci 9:204. 2015..This review will examine the Teneurins as synaptic cell adhesion molecules, explore how they regulate synaptic organization, and consider how some consequences of human Teneurin mutations may have synaptopathic origins. ..
- Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogasterAoife Larkin
Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia
Eur J Neurosci 42:2455-66. 2015..We examined the effects of neurexin-1 perturbation on sleep in Drosophila, showing that neurexin-1 nulls displayed fragmented sleep and altered ..
- ELAV-mediated 3'-end processing of ewg transcripts is evolutionarily conserved despite sequence degeneration of the ELAV-binding siteIrmgard U Haussmann
School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
Genetics 189:97-107. 2011..melanogaster is sufficient for ELAV recruitment in vivo. Hence, our data suggest that ELAV/Hu protein-regulated alternative RNA processing is more conserved than anticipated from the alignment of degenerate low-complexity sequences...
- The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and EnabledWangsun Choi
Department of Biology, University of North Carolina at Chapel Hill, USA
Mol Biol Cell 22:2010-30. 2011..Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure...
- Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and functionKarzan Muhammad
Freie Universitat Berlin, Institute for Biology Genetics, Takustrasse 6, Berlin 14195, Germany
Nat Commun 6:8362. 2015Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin...
- Temporal and spatial expression of Drosophila Neurexin during the life cycle visualized using a DNRX-Gal4/UAS-reporterMingkuan Sun
The Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, 210096, China
Sci China Life Sci 59:68-77. 2016b>Drosophila neurexin (DNRX) plays a critical role in proper architecture development and synaptic function in vivo. However, the temporal and spatial expression pattern of DNRX still remains unclear...
- A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular JunctionMikolaj J Sulkowski
Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, Maryland, United States of America
PLoS Genet 12:e1005810. 2016..Thus, BMP pathway may monitor synapse activity then function to adjust synapse growth and maturation during development. ..
- The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signalingKathryn P Harris
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States
elife 5:. 2016..Our findings suggest a conserved postsynaptic SNARE machinery controls multiple aspects of retrograde signaling and cargo trafficking within the postsynaptic compartment. ..
- Neurexin, Neuroligin and Wishful Thinking coordinate synaptic cytoarchitecture and growth at neuromuscular junctionsSwati Banerjee
Department of Cellular and Integrative Physiology, School of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA Electronic address
Mol Cell Neurosci 78:9-24. 2016..In Drosophila, while Neurexin (Dnrx) and Neuroligins (Dnlg) are emerging as central organizing molecules at synapses, very little is known of ..
- Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assemblyDavid Owald
Freie Universitat Berlin, Institute for Biology Genetics, Berlin, Germany
Nat Neurosci 15:1219-26. 2012..Synapse formation and maturation requires bidirectional communication across the synaptic cleft. The trans-synaptic Neurexin-Neuroligin complex can bridge this cleft, and severe synapse assembly deficits are found in Drosophila ..
- Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJAndre Koper
Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester, United Kingdom
PLoS ONE 7:e36339. 2012..Therefore, future developmental studies of these synaptic junctions in Drosophila need to consider the important contribution made by BM-dependent mechanisms, in addition to CAM-dependent adhesion...
- Structure and evolution of neurexin genes: insight into the mechanism of alternative splicingKatsuhiko Tabuchi
Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Genomics 79:849-59. 2002..We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from ..
- Genetic interaction between Neurexin and CAKI/CMG is important for synaptic function in Drosophila neuromuscular junctionMingkuan Sun
Department of Genetics and Developmental Biology, Southeast University Medical School, The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, China
Neurosci Res 64:362-71. 2009..Recent genetic studies using Drosophila melanogaster have implicated an essential role for a single Drosophila neurexin (dnrx) in the proper architecture, development and function of synapses in vivo...
- Adhesion proteins and the control of cell shapeRichard W Carthew
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
Curr Opin Genet Dev 15:358-63. 2005..Recent insights into adherens junction remodeling have revealed the importance of polarized localization of myosin and Par3 at the adherens junction...
- Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartmentBill Adolfsen
The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
J Cell Biol 166:249-60. 2004..In addition, the identification of a postsynaptic synaptotagmin suggests calcium-dependent membrane-trafficking functions on both sides of the synapse...
- Discs-Large and Strabismus are functionally linked to plasma membrane formationOk kyung Lee
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Nat Cell Biol 5:987-93. 2003..This effect was dependent on the interaction between Stbm and SAP97. These findings suggest that the Dlg-Stbm complex recruits membrane-associated proteins and lipids from internal membranes to sites of new plasma membrane formation...
- PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTIONRichard Carthew; Fiscal Year: 2005..abstract_text> ..