nonA

Summary

Gene Symbol: nonA
Description: no on or off transient A
Alias: Bj6, Bj6-1, CG4211, Dmel\CG4211, NONA, NonA, diss, non-A, nonA/diss, opm2, p54[nrb], x14, CG4211 gene product from transcript CG4211-RB, Bj6-monoclonal-antibody, CG4211-PA, CG4211-PB, CG4211-PC, CG4211-PD, dissonance, no on or off transient-A, no-on transient A, no-on-transient A, no-on-transient-A, non-on-transient-A, nonA-PA, nonA-PB, nonA-PC, nonA-PD, positive spike II group
Species: fruit fly

Top Publications

  1. ncbi The target of Drosophila photoreceptor synaptic transmission is a histamine-gated chloride channel encoded by ort (hclA)
    Chaoxian Gengs
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 277:42113-20. 2002
  2. ncbi Genetic lesions in Drosophila behavioural mutants
    G O Pflugfelder
    Theodor Boveri Institut Biozentrum, Lehrstuhl fur Genetik, Universität Würzburg Am Hubland, Germany
    Behav Brain Res 95:3-15. 1998
  3. ncbi small wing encodes a phospholipase C-(gamma) that acts as a negative regulator of R7 development in Drosophila
    J R Thackeray
    Department of Biology, Yale University, PO Box 208103, New Haven, CT 06520, USA
    Development 125:5033-42. 1998
  4. ncbi The puff-specific RRM protein NonA is a single-stranded nucleic acid binding protein
    I Reim
    Institut fur Biologie, Abt Zytogenetik, Humboldt Universitat zu Berlin, Chausseestrasse 117, D 10115 Berlin, Germany
    Chromosoma 108:162-72. 1999
  5. ncbi The RRM protein NonA from Drosophila forms a complex with the RRM proteins Hrb87F and S5 and the Zn finger protein PEP on hnRNA
    I Reim
    Institut für Biologie Abt Zytogenetik, Humboldt Universitat zu Berlin, Berlin, D 10115, Germany
    Exp Cell Res 253:573-86. 1999
  6. pmc Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells
    Caroline Jolly
    INSERM U309, La Tronche, F 38700, France
    Nucleic Acids Res 34:5508-14. 2006
  7. ncbi Studies on the role of NonA in mRNA biogenesis
    Natalia Kozlova
    Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
    Exp Cell Res 312:2619-30. 2006
  8. ncbi Myotonic dystrophy associated expanded CUG repeat muscleblind positive ribonuclear foci are not toxic to Drosophila
    Jonathan M Houseley
    Institute of Biomedical and Life Sciences, University of Glasgow, UK
    Hum Mol Genet 14:873-83. 2005
  9. ncbi Structures and dynamics of Drosophila Tpr inconsistent with a static, filamentous structure
    Grazyna Zimowska
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida 32610 0235, USA
    Exp Cell Res 276:223-32. 2002
  10. ncbi The protein Hrb57A of Drosophila melanogaster closely related to hnRNP K from vertebrates is present at sites active in transcription and coprecipitates with four RNA-binding proteins
    B T Hovemann
    Fakultaet fuer Chemie AG, Molekulare Zellbiochemie, Ruhr Universitaet, Bochum, Germany
    Gene 245:127-37. 2000

Research Grants

  1. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
  2. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007

Scientific Experts

  • Subhash C Lakhotia
  • J M Gleason
  • Susanna Huttunen
  • M Heisenberg
  • Grazyna Zimowska
  • J C Hall
  • J R Thackeray
  • Caroline Jolly
  • G O Pflugfelder
  • LESLIE GRIFFITH
  • Anand K Singh
  • S Campesan
  • I Reim
  • Neus Visa
  • Chunghun Lim
  • H Saumweber
  • Vibha Dwivedi
  • Maria C Onorati
  • Timothy J Mosca
  • James E C Jepson
  • Viktoria Hessle
  • Jessica A Hurt
  • Marta Vicente-Crespo
  • D Yamamoto
  • F Sandrelli
  • Natalia Kozlova
  • K G Rendahl
  • Qiaoqiao Wang
  • Jonathan M Houseley
  • R Stanewsky
  • Eva Kiesler
  • Chaoxian Gengs
  • Ravi Allada
  • Mousumi Mutsuddi
  • E M Anandan
  • R Costa
  • Rajesh S Mony
  • T S Muraleedharan
  • M S Valiathan
  • C P Kyriacou
  • A Megighian
  • Davide F V Corona
  • Moushami Mallik
  • Anna P Carreca
  • Sandra Lazzaro
  • Deo Prakash Chaturvedi
  • Antonia M R Ingrassia
  • B T Hovemann
  • Thomas L Schwarz
  • Marcus Sokolowski
  • Petra Bjork
  • Robert A Obar
  • Steven P Gygi
  • Gianluca Maddalo
  • Roger Helbig
  • Konstantin Artemenko
  • Robert A Reenan
  • Anu Tyagi
  • Natalie G Farny
  • Pamela A Silver
  • Leopold Ilag
  • Ernesto González de Valdivia
  • Roman A Zubarev
  • Bo Zhai
  • Rebecca Silverstein
  • Amparo Garcia-Lopez
  • Ruben D Artero
  • Lidon Monferrer
  • Maya Pascual
  • Lei Zhou
  • M Eugenia Miranda
  • Juan M Fernandez-Costa
  • Y Nakano
  • José Rino
  • Maria Carmo-Fonseca
  • Josefin Lundgren
  • Patrick Young
  • José Braga
  • Judith Soloway
  • Gordon G Carmichael
  • Manuel Perez-Alonso
  • Zongsheng Wang
  • Zuo Zhang
  • Kevin M C O'Dell
  • Darren G Monckton
  • Ruben Artero
  • Graham J R Brock
  • Katherine Blackwell
  • E Johnson
  • Ann Kristin Ostlund Farrants

Detail Information

Publications54

  1. ncbi The target of Drosophila photoreceptor synaptic transmission is a histamine-gated chloride channel encoded by ort (hclA)
    Chaoxian Gengs
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 277:42113-20. 2002
    ..Moreover, the present work shows that this function of the HCLA (ORT) protein is its native function in vivo...
  2. ncbi Genetic lesions in Drosophila behavioural mutants
    G O Pflugfelder
    Theodor Boveri Institut Biozentrum, Lehrstuhl fur Genetik, Universität Würzburg Am Hubland, Germany
    Behav Brain Res 95:3-15. 1998
    ..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations...
  3. ncbi small wing encodes a phospholipase C-(gamma) that acts as a negative regulator of R7 development in Drosophila
    J R Thackeray
    Department of Biology, Yale University, PO Box 208103, New Haven, CT 06520, USA
    Development 125:5033-42. 1998
    ..The data presented here provide the first genetic evidence that PLC-(gamma) is involved in Ras-mediated signaling and indicate that PLC-(gamma) acts as a negative regulator in such pathways in Drosophila...
  4. ncbi The puff-specific RRM protein NonA is a single-stranded nucleic acid binding protein
    I Reim
    Institut fur Biologie, Abt Zytogenetik, Humboldt Universitat zu Berlin, Chausseestrasse 117, D 10115 Berlin, Germany
    Chromosoma 108:162-72. 1999
    The chromatin protein NonA from Drosophila, present in many puffs on polytene chromosomes, belongs to the growing class of RRM proteins...
  5. ncbi The RRM protein NonA from Drosophila forms a complex with the RRM proteins Hrb87F and S5 and the Zn finger protein PEP on hnRNA
    I Reim
    Institut für Biologie Abt Zytogenetik, Humboldt Universitat zu Berlin, Berlin, D 10115, Germany
    Exp Cell Res 253:573-86. 1999
    The RRM protein NonA, an ubiquitous nuclear protein present in puffs on polytene chromosomes, has been immunopurified as a RNA-protein complex from Drosophila Kc cells...
  6. pmc Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells
    Caroline Jolly
    INSERM U309, La Tronche, F 38700, France
    Nucleic Acids Res 34:5508-14. 2006
    ....
  7. ncbi Studies on the role of NonA in mRNA biogenesis
    Natalia Kozlova
    Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
    Exp Cell Res 312:2619-30. 2006
    The NonA protein of Drosophila melanogaster is an abundant nuclear protein that belongs to the DBHS (Drosophila behavior, human splicing) protein family...
  8. ncbi Myotonic dystrophy associated expanded CUG repeat muscleblind positive ribonuclear foci are not toxic to Drosophila
    Jonathan M Houseley
    Institute of Biomedical and Life Sciences, University of Glasgow, UK
    Hum Mol Genet 14:873-83. 2005
    ....
  9. ncbi Structures and dynamics of Drosophila Tpr inconsistent with a static, filamentous structure
    Grazyna Zimowska
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida 32610 0235, USA
    Exp Cell Res 276:223-32. 2002
    ....
  10. ncbi The protein Hrb57A of Drosophila melanogaster closely related to hnRNP K from vertebrates is present at sites active in transcription and coprecipitates with four RNA-binding proteins
    B T Hovemann
    Fakultaet fuer Chemie AG, Molekulare Zellbiochemie, Ruhr Universitaet, Bochum, Germany
    Gene 245:127-37. 2000
    ..coprecipitates four other proteins: Hrb87F/P11 a Drosophila hnRNP A1 homologue, the hnRNA-binding protein S5, the RNA recognition motif-containing protein NonA and the RNA-binding zinc finger-containing protein on ecdysone puffs PEP/X4.
  11. ncbi In vivo observation of the puff-specific protein no-on transient A (NONA) in nuclei of Drosophila embryos
    P Buchenau
    Abteilung Molekulare Biologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    J Cell Sci 106:189-99. 1993
    The spatial distribution of no-on transient A (NONA), a protein associated with specific puffs on polytene chromosomes, was followed in nuclei of living Drosophila embryos by microinjection of fluorescently labeled monoclonal antibody to ..
  12. doi ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila
    Chunghun Lim
    Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA
    Science 340:875-9. 2013
    ..Thus, ATX2 coordinates an active translation complex important for PER expression and circadian rhythms...
  13. doi Long non-coding RNAs coordinate cellular responses to stress
    Subhash C Lakhotia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Wiley Interdiscip Rev RNA 3:779-96. 2012
    ..Thus the stress-related lncRNAs act as hubs in the cellular networks to coordinate activities of the members within and between different networks to maintain cellular homeostasis for survival or to trigger cell death...
  14. pmc In vivo effects of traditional Ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications
    Vibha Dwivedi
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    PLoS ONE 7:e37113. 2012
    ..It is necessary to examine effects of the whole Ayurvedic formulations rather than their "active" components as is done in most current studies...
  15. ncbi The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster
    Anand K Singh
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Biosci 37:659-78. 2012
    ..Therefore, in spite of the functional redundancy provided by Hrp38, Hrp36 is essential for normal development and for survival under conditions of stress...
  16. pmc The ISWI chromatin remodeler organizes the hsrω ncRNA-containing omega speckle nuclear compartments
    Maria C Onorati
    Dulbecco Telethon Institute c o Università degli Studi di Palermo, Dipartimento STEMBIO Sezione Biologia Cellulare, Palermo, Italy
    PLoS Genet 7:e1002096. 2011
    ..Our findings highlight a novel role for chromatin remodelers in organization of nucleoplasmic compartments, providing the first example of interaction between an ATP-dependent chromatin remodeler and a large ncRNA...
  17. pmc The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development
    Timothy J Mosca
    The F M Kirby Neurobiology Center, Children s Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 13:935-43. 2010
    ..Thus, Wnt-activated growth of the postsynaptic membrane is mediated by the synapse-to-nucleus translocation and active nuclear import of Fz2-C via a selective Importin-beta11/alpha2 pathway...
  18. pmc Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila
    James E C Jepson
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 284:31391-400. 2009
    ....
  19. ncbi Mutations and natural genetic variation in the courtship song of Drosophila
    Jennifer M Gleason
    Department of Ecology and Evolutionary Biology, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS, USA
    Behav Genet 35:265-77. 2005
    ..With many new tools in genetic analysis and the multiple Drosophila genome projects currently underway, the ability to relate mutational and quantitative analyses will improve...
  20. ncbi The puff-specific Drosophila protein Bj6, encoded by the gene no-on transient A, shows homology to RNA-binding proteins
    H von Besser
    Institut für Entwicklungsphysiologie Universität zu Köln, Federal Republic of Germany
    Chromosoma 100:37-47. 1990
    The DNA coding for the puff-specific protein Bj6 has been isolated by expression cloning...
  21. pmc The nonA gene in Drosophila conveys species-specific behavioral characteristics
    S Campesan
    Department of Genetics, University of Leicester, Leicester LE1 7RH, United Kingdom
    Genetics 158:1535-43. 2001
    ..Mutations in nonA can disrupt both visual behavior and the courtship song in D. melanogaster. The lovesong of nonA(diss) mutant males superficially resembles that of D. virilis, a species that diverged from D. melanogaster 40-60 mya...
  22. ncbi Nucleotide variation at the no-on-transient A gene in Drosophila littoralis
    S Huttunen
    Department of Biology, University of Oulu, PO Box 3000, FIN 90014, Oulu, Finland
    Heredity (Edinb) 88:39-45. 2002
    The no-on-transient A (nonA) gene encodes a putative RNA-binding protein, and mutations in this gene are known to affect vision, male courtship song and viability in Drosophila melanogaster...
  23. ncbi Two proteins from Drosophila nuclei are bound to chromatin and are detected in a series of puffs on polytene chromosomes
    M Frasch
    Max Planck Institut für Entwicklungsbiologie Abt 1, Tubingen, Federal Republic of Germany
    Chromosoma 97:272-81. 1989
    ..The number of sites where these antigens can be detected, as well as the qualitative properties of the antigens at these sites differ between both proteins...
  24. ncbi The Drosophila Mutant tetanic Interacts with a Gene Complex Including the Structural Locus of K+ Channels and Shows Altered Dephosphorylation and Learning
    S Orgad
    Neurobiology Department, The Weizmann Institute for Science, Rehovot, Israel
    Eur J Neurosci 1:367-373. 1989
    ..The functional relationships between phosphorylation, K+ currents, phosphatase activity and modulation of synaptic activity during learning and memory are discussed in the light of their possible genetic links...
  25. ncbi Courtship lite: a personal history of reproductive behavioral neurogenetics in Drosophila
    Jeffrey C Hall
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurogenet 16:135-63. 2002
  26. ncbi The Hrp65 self-interaction is mediated by an evolutionarily conserved domain and is required for nuclear import of Hrp65 isoforms that lack a nuclear localization signal
    Eva Kiesler
    Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
    J Cell Sci 116:3949-56. 2003
    ..We also show that the protein-binding domains of Drosophila NonA and human PSF, two other proteins with conserved DBHS domains, bind to Hrp65 in the yeast two-hybrid system...
  27. ncbi Molecular analysis of no-on-transient A, a gene required for normal vision in Drosophila
    K R Jones
    Department of Molecular and Cell Biology, University of California Berkeley 94720
    Neuron 4:711-23. 1990
    Mutation of the Drosophila melanogaster gene no-on-transient A (nonA) results in reduced visual acuity, behavior abnormalities, and an electrophysiological defect for which the mutant is named...
  28. ncbi Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin
    Qiaoqiao Wang
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030 USA
    Curr Biol 15:384-91. 2005
    ..These results are consistent with a mechanistic link between components of the DNA-repair machinery and RNA-mediated gene silencing...
  29. ncbi Two puff-specific proteins bind within the 2.5 kb upstream region of the Drosophila melanogaster Sgs-4 gene
    H Saumweber
    Institut für Entwicklungsphysiologie Universität zu Köln, Federal Republic of Germany
    Chromosoma 99:52-60. 1990
    The Drosophila nuclear proteins Bj6 and Bx42 characterized previously are detected in a series of developmentally active puffs on salivary gland chromosomes...
  30. ncbi Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating
    D Yamamoto
    ERATO Yamamoto Behavior Genes Project, Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo, Japan
    Cell Mol Life Sci 56:634-46. 1999
    ..The issue as to how the mutations that reduce female sexual receptiveness, e.g. dissatisfaction (dsf), spinster (spin) and chaste (cht), affect the structure and/or function of this neural center deserves to be addressed urgently...
  31. pmc Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis
    Marta Vicente-Crespo
    Department of Genetics, University of Valencia, Valencia, Spain
    PLoS ONE 3:e1613. 2008
    ..Such transition fails in the CTG repeat expansion disease myotonic dystrophy due, in part, to sequestration of MBNL proteins by CUG repeat RNA. Four protein isoforms (MblA-D) are coded by the unique Drosophila muscleblind gene...
  32. pmc A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export
    Jessica A Hurt
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 185:265-77. 2009
    ..Our data suggest a model wherein ZC3H3 interfaces between the polyadenylation machinery, newly poly(A) mRNAs, and factors for transcript export...
  33. pmc The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteins
    Viktoria Hessle
    Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
    Mol Biol Cell 20:3459-70. 2009
    ..Our results lead to a revised mechanistic model for cotranscriptional quality control in which the exosome is constantly recruited to newly synthesized RNAs through direct interactions with specific hnRNP proteins...
  34. ncbi The dissonance mutation at the no-on-transient-A locus of D. melanogaster: genetic control of courtship song and visual behaviors by a protein with putative RNA-binding motifs
    K G Rendahl
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    J Neurosci 12:390-407. 1992
    Genetic and molecular results are here presented revealing that the dissonance (diss) courtship song mutation is an allele of the no-on-transient-A (nonA) locus of Drosophila melanogaster...
  35. ncbi Artificial neural network classification of Drosophila courtship song mutants
    E K Neumann
    Department of Biology, Brandeis University, Waltham, MA 02254
    Biol Cybern 66:485-96. 1992
    Courtship songs produced by Drosophila males--wild-type, plus the cacophony and dissonance behavioral mutants--were examined with the aid of newly developed strategies for adaptive acoustic analysis and classification...
  36. ncbi Temporally manipulated rescue of visual and courtship abnormalities caused by a nonA mutation in Drosophila
    K G Rendahl
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    J Neurogenet 10:247-56. 1996
    ..The nonA(diss) mutant is abnormal for all of these phenotypes. The pleiotropic effects of this dissonance allele dovetail with the widespread tissue expression of the nonA products...
  37. ncbi Drosophila in vision research. The Friedenwald Lecture
    W L Pak
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    Invest Ophthalmol Vis Sci 36:2340-57. 1995
    ....
  38. ncbi Molecular cloning of mei-41, a gene that influences both somatic and germline chromosome metabolism of Drosophila melanogaster
    S S Banga
    Section of Molecular and Cellular Biology, University of California Davis 95616
    Mol Gen Genet 246:148-55. 1995
    ..This study provides the foundation for molecular analysis of a function that is essential for chromosome stability in both the germline and somatic cells...
  39. pmc Ecdysone regulation of the Drosophila Sgs-4 gene is mediated by the synergistic action of ecdysone receptor and SEBP 3
    M Lehmann
    Institut fur Genetik, Freien Universitat Berlin, Germany
    EMBO J 14:716-26. 1995
    ..Thus, the available data suggest that induction of Sgs-4, and possibly other 'intermolt genes', is a combination of a primary and a secondary response to the hormone...
  40. ncbi The mating of a fly
    J C Hall
    Department of Biology, Brandeis University, Waltham, MA 02254 9110
    Science 264:1702-14. 1994
    ..Further behavioral mutations seemed originally to be courtship-specific, turned out not to have that property, and have led to a broadened perspective on the nature and action of Drosophila's sex-determination genes...
  41. pmc Genetic and molecular analysis of the X chromosomal region 14B17-14C4 in Drosophila melanogaster: loss of function in NONA, a nuclear protein common to many cell types, results in specific physiological and behavioral defects
    R Stanewsky
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Genetics 135:419-42. 1993
    ..14C region of the X chromosome of Drosophila melanogaster to isolate loss of function alleles of no-on-transient A (nonA; 14C1-2; 1-52.3)...
  42. pmc Genetic dissection of the Drosophila nervous system by means of mosaics
    Y Hotta
    Proc Natl Acad Sci U S A 67:1156-63. 1970
    ..e., a mutant eye always functions abnormally, regardless of the amount of normal tissue present elsewhere, indicating that the primary causes of the behavioral deficits in these mutants are within the eye...
  43. pmc NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss
    Y S Yang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235 9048
    Mol Cell Biol 13:5593-603. 1993
    ..to be the mammalian equivalent of the Drosophila visual and courtship song behavior protein, no-on-transient A/dissonance (nonAdiss)...
  44. pmc Isolation of RRM-type RNA-binding protein genes and the analysis of their relatedness by using a numerical approach
    Y J Kim
    Department of Biological Sciences, Stanford University, California 94305
    Mol Cell Biol 13:174-83. 1993
    ..This result suggests that we have isolated good candidates for both housekeeping and developmentally important genes involved in RNA metabolism...
  45. pmc Bioassaying putative RNA-binding motifs in a protein encoded by a gene that influences courtship and visually mediated behavior in Drosophila: in vitro mutagenesis of nonA
    R Stanewsky
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Genetics 143:259-75. 1996
    The no-on-transient-A (nonA) gene of Drosophila melanogaster influences vision, courtship song, and viability. The nonA-encoded polypeptide is inferred to bind single-stranded nucleic acids...
  46. ncbi Defects in courtship and vision caused by amino acid substitutions in a putative RNA-binding protein encoded by the no-on-transient A (nonA) gene of Drosophila
    K G Rendahl
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    J Neurosci 16:1511-22. 1996
    The Drosophila no-on-transient A (nonA) gene is involved in the visual behaviors and courtship song of the fly...
  47. ncbi Mutants of the visual pathway of Drosophila melanogaster
    W L Pak
    Nature 227:518-20. 1970
  48. ncbi Modulation of Drosophila heartbeat by neurotransmitters
    E Johnson
    Department of Zoology, University of Maine, Orono 04469, USA
    J Comp Physiol B 167:89-97. 1997
    ..Dopamine-N-acetyltransferase, which is on the catabolic route to dopamine, serotonin, and octopamine, has no effect. hypoactiveC reduces the rate of the heart, but its mechanism of action is unknown...
  49. ncbi Genetic approaches to neuroethology
    M Heisenberg
    Biozentrum, Lehrstuhl fur Genetik, Wurzburg, Germany
    Bioessays 19:1065-73. 1997
    ..The 'graininess' of a functional model of the brain, therefore, is defined by the independent regulatory units of the genes rather than by the genes themselves...
  50. ncbi Genes for sexual behavior
    D Yamamoto
    ERATO Yamamoto Behavior Genes Project, JST, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Biochem Biophys Res Commun 246:1-6. 1998
    ..This strategy of artificial control of fly behavior opens up an avenue for studies to identify the neural center for individual behavioral actions...
  51. pmc The dissonance mutant of courtship song in Drosophila melanogaster: isolation, behavior and cytogenetics
    S J Kulkarni
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    Genetics 118:267-85. 1988
    The dissonance mutant of courtship song was induced by chemical mutagenesis. This X-chromosomal mutation causes the D...
  52. ncbi Spectral analysis of courtship songs in behavioral mutants of Drosophila melanogaster
    D A Wheeler
    Behav Genet 19:503-28. 1989
    Spectral analyses were applied to the courtship songs of the mutants cacophony (cac), dissonance (diss), fruitless (fru), and period (per), as well as to the double mutant cac diss...
  53. pmc Molecular Dissection of the 5' Region of no-on-transientA of Drosophila melanogaster Reveals cis-Regulation by Adjacent dGpi1 Sequences
    F Sandrelli
    Dipartimento di Biologia, Universita di Padova, 35131 Padova, Italy
    Genetics 157:765-75. 2001
    The nonA gene of Drosophila melanogaster is important for normal vision, courtship song, and viability and lies approximately 350 bp downstream of the dGpi1 gene...
  54. pmc Comparative analysis of the nonA region in Drosophila identifies a highly diverged 5' gene that may constrain nonA promoter evolution
    S Campesan
    Department of Genetics, University of Leicester, Leicester LE1 7RH, England
    Genetics 157:751-64. 2001
    A genomic fragment from Drosophila virilis that contained all the no-on-transientA (nonA) coding information, plus several kilobases of upstream material, was identified. Comparisons of nonA sequences and the gene nonA-like in D...

Research Grants2

  1. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
    ..of chronobiology in this model system may provide insights into the nature of certain rhythm-related disorders of humans, some of which are associated with genetic variations of Drosophila clock gene orthologs [unreadable] [unreadable]..
  2. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
    ..melanogaster ..