NetB

Summary

Gene Symbol: NetB
Description: Netrin-B
Alias: CG10521, CT29512, Dmel\CG10521, NETB, net, netB, netrin, netrin B, CG10521 gene product from transcript CG10521-RD, CG10521-PA, CG10521-PB, CG10521-PC, CG10521-PD, CG10521-PE, CG10521-PF, CG10521-PG, D-netrin, D-netrin-B, NetB-PA, NetB-PB, NetB-PC, NetB-PD, NetB-PE, NetB-PF, NetB-PG, netrin, netrin B, netrin-B, netrinB
Species: fruit fly

Top Publications

  1. ncbi "Painting" the target: how local molecular cues define synaptic relationships
    A Chiba
    Department of Cell and Structural Biology, University of Illinois, Urbana, USA
    Bioessays 20:941-8. 1998
  2. ncbi Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development
    A Chiba
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign 61801, USA
    Int Rev Neurobiol 43:1-24. 1999
  3. ncbi Forked end: a novel transmembrane protein involved in neuromuscular specificity in drosophila identified by gain-of-function screening
    Takeshi Umemiya
    Department of Physics, Graduate School of Science, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurobiol 51:205-14. 2002
  4. pmc Midline governs axon pathfinding by coordinating expression of two major guidance systems
    Qing Xin Liu
    Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Genes Dev 23:1165-70. 2009
  5. ncbi Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs
    R Harris
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Neuron 17:217-28. 1996
  6. pmc Blocking apoptotic signaling rescues axon guidance in Netrin mutants
    Gunnar Newquist
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Cell Rep 3:595-606. 2013
  7. pmc How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS
    Irina Kuzina
    National Institute of Neurological Disorders and Stroke and National Human Genome Research Institute NIH, Bethesda, MD 20892, USA
    Development 138:1839-49. 2011
  8. doi The transmembrane receptor Uncoordinated5 (Unc5) is essential for heart lumen formation in Drosophila melanogaster
    Stefanie Albrecht
    Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie Entwicklungsbiologie, Barbarastraße 11, 49069 Osnabruck, Germany
    Dev Biol 350:89-100. 2011
  9. doi Netrins guide migration of distinct glial cells in the Drosophila embryo
    Christian M von Hilchen
    Institute of Genetics, University of Mainz, Saarstrasse 21, Mainz, Germany
    Development 137:1251-62. 2010
  10. pmc Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map
    David J Brierley
    Medical Research Council MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS Biol 7:e1000199. 2009

Research Grants

  1. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
  2. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
  3. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
  4. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008

Scientific Experts

  • YUH N JAN
  • S M Hughes
  • Judith Eisen
  • Guy Tear
  • M A Seeger
  • Masaki Hiramoto
  • Krishna Bhat
  • Akira Chiba
  • Bader Al-Anzi
  • Gunnar Newquist
  • Greg J Bashaw
  • Thomas Kidd
  • Juan Pablo Labrador
  • David S Garbe
  • Jamshid Asadzadeh
  • Naomi Halachmi
  • Hong Long
  • Marie Sophie Cate
  • Marko Brankatschk
  • Cristina Organisti
  • Melissa Pert
  • Sunita G Kramer
  • Takashi Suzuki
  • Matthew Y Pecot
  • Robert Saint
  • Satoko Hakeda-Suzuki
  • Michael J Murray
  • Brian O Orr
  • Sarah K R Long
  • Michael P O'Donnell
  • Matthew Lamanuzzi
  • Kirsti Walker
  • Rosemary Manhire-Heath
  • Frank D Macabenta
  • Irina Hein
  • Katarina Timofeev
  • Rei K Morikawa
  • Benjamin J Matthews
  • Stefanie Albrecht
  • Irina Kuzina
  • Benjamin Altenhein
  • Shingo Yoshikawa
  • John B Thomas
  • Bettina Spitzweck
  • Joy N Dorsten
  • Christian M von Hilchen
  • Eli M Mrkusich
  • Molly Duman-Scheel
  • Qing Xin Liu
  • Wendy Simanton
  • David J Brierley
  • Long Yang
  • Iris Salecker
  • Barry J Dickson
  • Gracie L Andrews
  • Tereza Kolesnikov
  • Hiroko Sano
  • C S Goodman
  • Susanne Onel
  • Carole Chotard
  • Niamh Neligan
  • Kevin J Mitchell
  • Thomas Raabe
  • Sangeetha Gajendra
  • K J Mitchell
  • Marie Pierre Furrer
  • Adi Salzberg
  • Samantha Alsbury
  • Atalya Nachman
  • Anton J Enright
  • Miao Gan
  • Ilona C Grunwald Kadow
  • Rachana R Chandran
  • Takeshi Umemiya
  • Yi Chen
  • Zhenqing Chen
  • Mark A Melton
  • Lan Jiang
  • Eric Fulkerson
  • Rodney K Murphey
  • Orkun Akin
  • Melissa A Borgen
  • Napoleon Butler
  • Phyllis M Caruccio
  • C Y Kimberly Tsui
  • S Lawrence Zipursky
  • Cara Davis
  • Rebecca Breese
  • Patricia Estes
  • Giovanna Hernández

Detail Information

Publications65

  1. ncbi "Painting" the target: how local molecular cues define synaptic relationships
    A Chiba
    Department of Cell and Structural Biology, University of Illinois, Urbana, USA
    Bioessays 20:941-8. 1998
    ..In this review, we summarize how such studies are beginning to uncover the repertoire of extrinsic cues that influence the synaptic targeting of a single growth cone...
  2. ncbi Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development
    A Chiba
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign 61801, USA
    Int Rev Neurobiol 43:1-24. 1999
  3. ncbi Forked end: a novel transmembrane protein involved in neuromuscular specificity in drosophila identified by gain-of-function screening
    Takeshi Umemiya
    Department of Physics, Graduate School of Science, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurobiol 51:205-14. 2002
    ..During embryonic development, fend mRNA was detected in a subset of cells in the central nervous system and in the periphery. These results suggest that FEND is a novel axon guidance molecule involved in neuromuscular specificity...
  4. pmc Midline governs axon pathfinding by coordinating expression of two major guidance systems
    Qing Xin Liu
    Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Genes Dev 23:1165-70. 2009
    ..Midline is present on the promoter regions of these genes, indicating that Midline controls transcription directly. We propose that Midline controls axon pathfinding through coordinating the two guidance systems...
  5. ncbi Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs
    R Harris
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Neuron 17:217-28. 1996
    ..We have identified two Drosophila homologs of this protein family (Netrin-A and Netrin-B)...
  6. pmc Blocking apoptotic signaling rescues axon guidance in Netrin mutants
    Gunnar Newquist
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Cell Rep 3:595-606. 2013
    ..We uncover a mechanism for axon guidance by demonstrating that axons can accurately navigate in the absence of a Netrin gradient if apoptotic signaling is blocked...
  7. pmc How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS
    Irina Kuzina
    National Institute of Neurological Disorders and Stroke and National Human Genome Research Institute NIH, Bethesda, MD 20892, USA
    Development 138:1839-49. 2011
    ..This propels the axons as they establish the connection between successive segments...
  8. doi The transmembrane receptor Uncoordinated5 (Unc5) is essential for heart lumen formation in Drosophila melanogaster
    Stefanie Albrecht
    Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie Entwicklungsbiologie, Barbarastraße 11, 49069 Osnabruck, Germany
    Dev Biol 350:89-100. 2011
    ..Our findings support the idea that Unc5 is crucial for lumen formation and thereby represents a repulsive cue acting during Drosophila heart tube formation...
  9. doi Netrins guide migration of distinct glial cells in the Drosophila embryo
    Christian M von Hilchen
    Institute of Genetics, University of Mainz, Saarstrasse 21, Mainz, Germany
    Development 137:1251-62. 2010
    ..We show that in Netrin mutants, two distinct populations of glial cells are affected: longitudinal glia (LG) fail to migrate medially in ..
  10. pmc Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map
    David J Brierley
    Medical Research Council MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS Biol 7:e1000199. 2009
    ..of motoneuron dendrites in the leg neuropil is controlled by the midline signalling systems Slit-Robo and Netrin-Fra...
  11. pmc The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding
    Bader Al-Anzi
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Neural Dev 4:31. 2009
    ..Some of these molecules, such as the evolutionarily conserved netrin and slit proteins, are expressed in the embryonic midline, an area of extreme importance for early axon ..
  12. pmc A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance
    Long Yang
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Science 324:944-7. 2009
    ..Slit-roundabout repulsion and netrin-deleted in colorectal cancer (DCC) (frazzled) attraction must be tightly regulated to control midline axon ..
  13. pmc Dscam guides embryonic axons by Netrin-dependent and -independent functions
    Gracie L Andrews
    Department of Biology MS 314, University of Nevada, Reno, NV 89557, USA
    Development 135:3839-48. 2008
    Developing axons are attracted to the CNS midline by Netrin proteins and other as yet unidentified signals. Netrin signals are transduced in part by Frazzled (Fra)/DCC receptors...
  14. ncbi Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline
    David S Garbe
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:4325-34. 2007
    The conserved DCC ligand-receptor pair Netrin and Frazzled (Fra) has a well-established role in axon guidance. However, the specific sequence motifs required for orchestrating downstream signaling events are not well understood...
  15. ncbi Netrins guide Drosophila commissural axons at short range
    Marko Brankatschk
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Nat Neurosci 9:188-94. 2006
    ..Tethering endogenous netrin to the membrane selectively disrupts its long-range but not short-range activity, yet still allows normal ..
  16. ncbi ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized Netrin
    Masaki Hiramoto
    Department of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Nat Neurosci 9:58-66. 2006
    ..The initial trajectory of the longitudinal axons is guided by Netrin, which is localized on commissural axons by its receptor, Frazzled...
  17. ncbi The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in Drosophila
    Juan Pablo Labrador
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 15:1413-9. 2005
    ..using genetics and single-cell mRNA-expression analysis, we show that expression and requirement of different Netrin receptor combinations correlate with distinct dorsal and ventral motor-axon projections in Drosophila...
  18. ncbi Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline
    Marie Pierre Furrer
    Department of Cell and Structural Biology, University of Illinois, 601 South Goodwin Avenue, Urbana, Illinois 61801, USA
    Nat Neurosci 6:223-30. 2003
    ..single-cell labeling, we describe specific guidance defects in dendrites of identified neurons in frazzled, robo, netrin and commissureless mutant embryos of Drosophila melanogaster...
  19. ncbi Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
    K Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 32:605-17. 2001
    ..Here we report the identification of the Drosophila Unc5 receptor, and show that it is a repulsive Netrin receptor likely to contribute to motor axon guidance...
  20. ncbi The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution
    M Hiramoto
    Department of Developmental Genetics, National Institute of Genetics, Graduate University for Advanced Studies, Japan
    Nature 406:886-9. 2000
    b>Netrin is a secreted protein that can act as a chemotropic axon guidance cue...
  21. ncbi The netrin receptor frazzled is required in the target for establishment of retinal projections in the Drosophila visual system
    Q Gong
    Laboratory of Developmental Neurogenetics, The Rockefeller University, New York, NY 10021, USA
    Development 126:1451-6. 1999
    ..Our data suggest that Frazzled does not function as a Netrin receptor in attracting retinal fibers to the target; nor does it seem to act as a homotypic cell adhesion molecule...
  22. ncbi Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs
    M L Winberg
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 93:581-91. 1998
    ..recognize their appropriate muscle targets were dissected using Drosophila genetics to add or subtract Netrin A, Netrin B, Semaphorin II, and Fasciclin II alone or in combination...
  23. ncbi frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance
    P A Kolodziej
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0724, USA
    Cell 87:197-204. 1996
    ..The phenotypes strongly resemble those of a deletion of the two Drosophila Netrin genes...
  24. ncbi Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
    K J Mitchell
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley California 94720, USA
    Neuron 17:203-15. 1996
    Two tandem Netrin genes in Drosophila are expressed at the midline of the developing CNS and in different subsets of neurons, muscles, and epidermal patches...
  25. doi Netrin and Frazzled regulate presynaptic gap junctions at a Drosophila giant synapse
    Brian O Orr
    Department of Biological Sciences, Florida Atlantic University, Boca Raton, Florida 33431
    J Neurosci 34:5416-30. 2014
    b>Netrin and its receptor, Frazzled, dictate the strength of synaptic connections in the giant fiber system (GFS) of Drosophila melanogaster by regulating gap junction localization in the presynaptic terminal...
  26. pmc Frazzled/DCC facilitates cardiac cell outgrowth and attachment during Drosophila dorsal vessel formation
    Frank D Macabenta
    Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Dev Biol 380:233-42. 2013
    ..Previous studies have shown that the Slit/Roundabout and Netrin/Unc5 repulsive signaling pathways facilitate site-specific loss of adhesion between contralateral CBs in order to ..
  27. pmc Control of male and female fertility by the netrin axon guidance genes
    Gunnar Newquist
    Department of Biology, University of Nevada, Reno, Nevada, United States of America
    PLoS ONE 8:e72524. 2013
    The netrin axon guidance genes have previously been implicated in fertility in C. elegans and in vertebrates...
  28. doi Netrin-dependent downregulation of Frazzled/DCC is required for the dissociation of the peripodial epithelium in Drosophila
    Rosemary Manhire-Heath
    Department of Genetics, University of Melbourne, Melbourne, Victoria 3010, Australia
    Nat Commun 4:2790. 2013
    Netrins are secreted chemoattractants with roles in axon guidance, cell migration and epithelial plasticity. Netrin-1 also promotes the survival of metastasized cells by inhibiting the pro-apoptotic effects of its receptor Deleted in ..
  29. pmc A comparison of midline and tracheal gene regulation during Drosophila development
    Sarah K R Long
    Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 9:e85518. 2014
    ..Taken together, these experiments identify elements overrepresented within midline and tracheal enhancers and suggest that sequences immediately surrounding a CME help dictate whether a gene is expressed in the midline or trachea. ..
  30. pmc Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila
    Marie Sophie Cate
    MRC Centre for Developmental Neurobiology, New Hunts House, King s College, London, SE1 1UL, UK
    Development 143:972-7. 2016
    ..Recent genetic evidence suggests that a simple model of differential sensitivity to the conserved Netrin attractants and Slit repellents is insufficient to explain the guidance of all axons at the midline...
  31. pmc Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system
    Matthew Y Pecot
    Department of Biological Chemistry, The Howard Hughes Medical Institute, The David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 82:320-33. 2014
    ..L3 axons then produce Netrin, which regulates the layer-specific targeting of another neuron within the same circuit...
  32. ncbi Cell surface control of the layer specific targeting in the Drosophila visual system
    Satoko Hakeda-Suzuki
    Core Division of Advanced Research, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
    Genes Genet Syst 89:9-15. 2014
    ..Fundamental and comprehensive understanding of the crosstalk of growing axons and target regions in the Drosophila optic lobe will elucidate the general principles applicable to more complex nervous systems...
  33. doi Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance
    Cristina Organisti
    Max Planck Institute of Neurobiology, Sensory Neurogenetics Research Group, Am Klopferspitz 18, Martinsried, 82152, Germany
    Genes Cells 20:50-67. 2015
    ..In Drosophila, commissural axons sense the midline attractants Netrin A and B (Net) through Frazzled (Fra) receptors...
  34. pmc Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells
    Melissa Pert
    Department of Genetics, University of Melbourne, Vic, 3010, Australia
    Biol Open 4:233-43. 2015
    ..Both netrinA and netrinB are expressed in the visceral mesoderm, the substrate upon which midgut cells migrate, while their receptor ..
  35. doi A newly identified type of attachment cell is critical for normal patterning of chordotonal neurons
    Naomi Halachmi
    Department of Genetics, The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa 3109601, Israel
    Dev Biol 411:61-71. 2016
    ....
  36. pmc Equivalent Activities of Repulsive Axon Guidance Receptors
    Hong Long
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    J Neurosci 36:1140-50. 2016
    ....
  37. pmc Tinman Regulates NetrinB in the Cardioblasts of the Drosophila Dorsal Vessel
    Jamshid Asadzadeh
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 11:e0148526. 2016
    ..5. NetrinB (NetB), a repulsive ligand for the Unc-5 receptor is required to preserve the dorsal vessel hollow...
  38. pmc Netrin-guided accessory cell morphogenesis dictates the dendrite orientation and migration of a Drosophila sensory neuron
    Eli M Mrkusich
    Department of Anatomy and Cell Biology, University of Melbourne, VIC 3010, Australia
    Development 137:2227-35. 2010
    ..Cap cell morphogenesis is regulated by Netrin-A, which is produced by epidermal cells at the destination of the cap cell process...
  39. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
    ..Application to the D. melanogaster, Drosophila pseudoobscura and Anopheles gambiae genomes identifies several hundred target genes potentially regulated by one or more known miRNAs...
  40. pmc Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits
    Michael P O'Donnell
    Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 140:2724-33. 2013
    ..We identified Abl in a genetic screen for genes that contribute to Netrin-dependent axon guidance in midline-crossing (commissural) neurons...
  41. pmc Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila
    Katarina Timofeev
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, London, UK
    Neuron 75:80-93. 2012
    ..b>Netrin-B is specifically localized in this layer owing to axonal release by lamina neurons L3 and capture by target ..
  42. pmc Different levels of the Tripartite motif protein, Anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neurons
    Rei K Morikawa
    Department of Cell Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 108:19389-94. 2011
    ..We also show by biochemical and genetic analysis that Asap regulates Netrin signaling, at least in part by linking the Netrin receptor Frazzled to the downstream effector Pico...
  43. pmc Dscam1-mediated self-avoidance counters netrin-dependent targeting of dendrites in Drosophila
    Benjamin J Matthews
    Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Biol 21:1480-7. 2011
    ..show that Dscam1 functions to counter Drosophila sensory neuron dendritic targeting signals provided by secreted Netrin-B and Frazzled, a netrin receptor...
  44. ncbi Attraction versus repulsion: modular receptors make the difference in axon guidance
    M A Seeger
    Department of Molecular Genetics, Ohio State University, Columbus 43210, USA
    Cell 97:821-4. 1999
  45. ncbi Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo
    Q Sun
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Development 127:801-12. 2000
    ....
  46. ncbi The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit
    Susanne Onel
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Development 131:2587-94. 2004
    ..Two evolutionarily conserved signaling molecules, Netrin and Slit, are expressed in the CNS midline cells...
  47. ncbi Neurons and glia: team players in axon guidance
    Carole Chotard
    National Institute for Medical Research, Division of Molecular Neurobiology, The Ridgeway, London NW7 1AA, UK
    Trends Neurosci 27:655-61. 2004
    ..Equally, neurons provide crucial information to glia, supporting their migration and correct positioning...
  48. pmc Slit-roundabout signaling neutralizes netrin-Frazzled-mediated attractant cue to specify the lateral positioning of longitudinal axon pathways
    Krishna Moorthi Bhat
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322
    Genetics 170:149-59. 2005
    ..that in the Drosophila nerve cord the growth cones of longitudinal tracts are subjected to attraction by the Netrin-Frazzled pathway...
  49. ncbi Axon guidance at the central nervous system midline
    G Tear
    Molecular Neurobiology Group, Guy s Hospital Campus, King s College, London
    Cell Mol Life Sci 55:1365-76. 1999
    ..In this way, axons extend toward or away from the midline and those that do cross change their behaviour to respond to longitudinal signals on the contralateral side...
  50. ncbi Frazzled precision guides axons
    R J Giger
    Nature 406:841, 843. 2000
  51. ncbi Slit proteins: key regulators of axon guidance, axonal branching, and cell migration
    K Brose
    Departments of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 0452, USA
    Curr Opin Neurobiol 10:95-102. 2000
    ....
  52. pmc Regulation of axon guidance by slit and netrin signaling in the Drosophila ventral nerve cord
    Krishna Moorthi Bhat
    Department of Neuroscience and Cell Biology, School of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Genetics 176:2235-46. 2007
    b>Netrin and Slit signaling systems play opposing roles during the positioning of longitudinal tracts along the midline in the ventral nerve cord of Drosophila embryo...
  53. ncbi NETRIN and SLIT guide salivary gland migration
    Tereza Kolesnikov
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Dev Biol 284:102-11. 2005
    ..Here, we show that at least two of these axon guidance molecules, NETRIN and SLIT, act through their canonical receptors, to guide Drosophila embryonic salivary glands...
  54. ncbi Neuronal guidance. A genetic perspective
    G Tear
    Department of Biochemistry, Imperial College, London, UK
    Trends Genet 15:113-8. 1999
    ..Here I highlight the part genetic screens and analyses have played in revealing some of the key players in neuronal guidance...
  55. pmc Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2
    Hiroko Sano
    Department of Cell Biology, Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Howard Hughes Medical Institute, New York University Medical Center, New York, NY 10016
    J Cell Biol 171:675-83. 2005
    ..Our results suggest that expression of wun/wun-2 repellents along the migratory paths provides faithful control over the sorting of PGCs into two gonads and eliminates PGCs left in the middle of the embryo...
  56. ncbi Netrins find their receptor
    U Drescher
    Nature 384:416-7. 1996
  57. pmc In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS
    Joy N Dorsten
    Department of Biological Sciences, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 5:e9822. 2010
    In the Drosophila embryonic nerve cord, the formation of commissures require both the chemoattractive Netrin receptor Frazzled (Fra) and the Abelson (Abl) cytoplasmic tyrosine kinase...
  58. ncbi Axon guidance: netrin receptors are revealed
    S Guthrie
    Department of Developmental Neurobiology, UMDS, Guy s Hospital, London SE1 9RT, UK
    Curr Biol 7:R6-9. 1997
    ..Now, members of a family of netrin receptors have been identified in all three animal groups and shown to have crucial, conserved roles in axon ..
  59. doi Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors
    Bettina Spitzweck
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 140:409-20. 2010
    ..These data demonstrate how diversification of expression and structure within a single family of guidance receptors can shape complex patterns of neuronal wiring...
  60. ncbi Control of muscle fibre and motoneuron diversification
    S M Hughes
    MRC Muscle and Cell Motility Unit Developmental Biology Research Centre The Randall Institute King s College London 26 29 Drury Lane London WC2B 5RL UK
    Curr Opin Neurobiol 9:54-64. 1999
    ..We propose a model in which four classes of decision control the patterning of both motoneurons and muscles...
  61. ncbi Wrapper, a novel member of the Ig superfamily, is expressed by midline glia and is required for them to ensheath commissural axons in Drosophila
    J N Noordermeer
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 21:991-1001. 1998
    ..However, they do not ensheath the commissural axons, and as a result, the glia die. In the absence of Wrapper, the two axon commissures are not properly separated...
  62. pmc Conservation of arthropod midline netrin accumulation revealed with a cross-reactive antibody provides evidence for midline cell homology
    Wendy Simanton
    Indiana University School of Medicine South Bend, Raclin Carmichael Hall, 1234 Notre Dame, Ave, South Bend, IN 46617, USA
    Evol Dev 11:260-8. 2009
    ..These comparative analyses were aided by a cross-reactive antibody generated against the Netrin (Net) protein, a midline cell marker and regulator of axonogenesis...
  63. ncbi Commissure formation in the embryonic CNS of Drosophila
    T Hummel
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Development 126:771-9. 1999
    ..Here we present evidence that beside the previously known NETRIN/FRAZZLED (DCC) signalling system an additional attractive system(s) is operating in the developing embryonic ..
  64. ncbi Genetic and molecular analyses of motoneuron development
    J S Eisen
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Curr Opin Neurobiol 8:697-704. 1998
    ..Many of the same molecules participate in the guidance of both vertebrate and fly motor axons. It is less clear, however, whether the same molecular mechanisms establish vertebrate and fly motoneuron identities...

Research Grants4

  1. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
    ..These studies will help understand pathways that govern the lineage elaboration in the Drosophila CNS as well as in other eukaryotic organisms including humans. ..
  2. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
    ..This work will provide insight into the role of these proteins in neurodegenerative diseases and development. ..
  3. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
    ..We propose that the Notch and Netrin signaling pathways interact during motoneuron development, resulting in limited access of specific zebrafish ..
  4. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008
    ..This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback. [unreadable] [unreadable] [unreadable]..