N

Summary

Gene Symbol: N
Description: Notch
Alias: 16-178, 16-55, CG3936, CT13012, Chp, Dmel\CG3936, EG:140G11.1, EG:163A10.2, NECD, NICD, RICN, anon-EST:Liang-1.12, clone 1.12, dNotch, l(1)3Cb, l(1)Ax, n[fah], notch, shd, spl, swb, CG3936 gene product from transcript CG3936-RA, CG3936-PA, CG3936-PB, N-PA, N-PB, NICD, abruptex, chopped, confluens, dNotch, facet, notch, notchoid, split, strawberry
Species: fruit fly

Top Publications

  1. ncbi Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis
    S S Huppert
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington 47405, USA
    Development 124:3283-91. 1997
  2. pmc cis-Inhibition of Notch by endogenous Delta biases the outcome of lateral inhibition
    Adam C Miller
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    Curr Biol 19:1378-83. 2009
  3. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
  4. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
  5. pmc Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway
    Julian C Boggiano
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
    Dev Cell 21:888-95. 2011
  6. ncbi Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing
    Dolors Ferres-Marco
    Instituto de Neurociencias CSIC UMH, Campus de San Juan, Apartado 18, 03550 Sant Joan, Alicante, Spain
    Nature 439:430-6. 2006
  7. ncbi Interaction between Wingless and Notch signaling pathways mediated by dishevelled
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 271:1826-32. 1996
  8. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
  9. pmc Endocytic internalization routes required for delta/notch signaling
    Sarah L Windler
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Curr Biol 20:538-43. 2010
  10. ncbi Cell death in normal and rough eye mutants of Drosophila
    T Wolff
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47906
    Development 113:825-39. 1991

Research Grants

  1. HEDGEHOG SIGNALING IN DEVELOPMENT AND DISEASE
    Thomas Kornberg; Fiscal Year: 2009
  2. Amyloid Precursor Protein Signaling
    Mark Bothwell; Fiscal Year: 2006
  3. Nogo Receptor Signaling and Function
    Mark Bothwell; Fiscal Year: 2007
  4. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
  5. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
  6. INTERACTION OF K PROTEIN WITH PROTEIN KINASES
    Karol Bomsztyk; Fiscal Year: 2007
  7. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
  8. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
  9. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
  10. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008

Detail Information

Publications205 found, 100 shown here

  1. ncbi Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis
    S S Huppert
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington 47405, USA
    Development 124:3283-91. 1997
    Delta and Notch are required for partitioning of vein and intervein cell fates within the provein during Drosophila metamorphosis...
  2. pmc cis-Inhibition of Notch by endogenous Delta biases the outcome of lateral inhibition
    Adam C Miller
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    Curr Biol 19:1378-83. 2009
    Lateral inhibition mediated by Delta/Notch (Dl/N) signaling is used throughout development to limit the number of initially equivalent cells that adopt a particular fate...
  3. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    b>Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development...
  4. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
    b>Notch function is required at the dorsoventral boundary of the developing Drosophila wing for its normal growth and patterning...
  5. pmc Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway
    Julian C Boggiano
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
    Dev Cell 21:888-95. 2011
    ..These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development...
  6. ncbi Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing
    Dolors Ferres-Marco
    Instituto de Neurociencias CSIC UMH, Campus de San Juan, Apartado 18, 03550 Sant Joan, Alicante, Spain
    Nature 439:430-6. 2006
    ..Together, these results establish a mechanism that links the Notch-Delta pathway, epigenetic silencing pathways and cell-cycle control in the process of tumorigenesis.
  7. ncbi Interaction between Wingless and Notch signaling pathways mediated by dishevelled
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 271:1826-32. 1996
    In Drosophila, the Wingless and Notch signaling pathways function in m any of the same developmental patterning events...
  8. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
    ..Numb, which also acts as a tumor suppressor in larval brains, is a major downstream target of AurA and aPKC. Notch activity is up-regulated in aurA and numb larval brains, and Notch signaling is necessary and sufficient to ..
  9. pmc Endocytic internalization routes required for delta/notch signaling
    Sarah L Windler
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Curr Biol 20:538-43. 2010
    ..clathrin, and AP-2 adaptor subunits to analyze internalization requirements for the Delta ligand and its receptor, Notch. Bulk Notch is internalized via AP-2-dependent endocytosis, but signaling by Notch requires AP-2-independent ..
  10. ncbi Cell death in normal and rough eye mutants of Drosophila
    T Wolff
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47906
    Development 113:825-39. 1991
    ..The use of an enhancer trap as a cell lineage marker shows that the cone cells, like other retinal cells, are not clonally related to each other or to their neighbors...
  11. pmc p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis
    T Adachi-Yamada
    Division of Biological Science, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, Chikusa ku, Nagoya 464 8602, Japan
    Mol Cell Biol 19:2322-9. 1999
    ..These results demonstrate that p38, in addition to its role as a transducer of emergency stress signaling, may function to modulate Dpp signaling...
  12. ncbi Analysis of genetic mosaics in developing and adult Drosophila tissues
    T Xu
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Development 117:1223-37. 1993
    ....
  13. pmc Common and distinct genetic properties of ESCRT-II components in Drosophila
    Hans Martin Herz
    Department of Biochemistry and Molecular Biology, The Genes and Development Graduate Program, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 4:e4165. 2009
    ..In Drosophila, mutations of the ESCRT-II component vps25 cause endosomal defects leading to accumulation of Notch protein and increased Notch pathway activity...
  14. ncbi Cell determination strategies in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 124:261-70. 1997
    ..Since inductive signalling is common in many organisms and its components have been conserved, it is possible that the logic of signalling may also be conserved...
  15. ncbi Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye
    K O Cho
    Department of Cell Biology, Program of Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 396:272-6. 1998
    ..Lack of a Fringe boundary disrupts equatorial expression of Notch signalling proteins and causes a complete failure of eye development...
  16. pmc Apical spectrin is essential for epithelial morphogenesis but not apicobasal polarity in Drosophila
    D C Zarnescu
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Cell Biol 146:1075-86. 1999
    ....
  17. ncbi Dorsoventral lineage restriction in wing imaginal discs requires Notch
    C A Micchelli
    Neuroscience Training Program, Department of Zoology, University of Wisconsin, Madison 53706, USA
    Nature 401:473-6. 1999
    ..ap expression also regulates signalling between dorsal and ventral compartments, resulting in high levels of Notch signalling at the D/V boundary...
  18. ncbi Regulation of post-embryonic neuroblasts by Drosophila Grainyhead
    Mara S Almeida
    Department of Anatomy, University of Cambridge, Downing Street, CA CB2 3DY, UK
    Mech Dev 122:1282-93. 2005
    ..We investigated three candidates; the Neuroblast identify gene Castor, the signalling molecule Notch and the adhesion protein E-Cadherin, to determine whether they could mediate these effects...
  19. ncbi Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila
    Luis M Escudero
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain
    Development 132:1211-22. 2005
    ..chn is also required for the proper development of the embryonic peripheral nervous system, as its absence leads to loss of neurons and causes aberrant development of chordotonal organs...
  20. pmc The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 14:535-46. 2008
    ..Our data describe a transit-amplifying lineage in the Drosophila nervous system and suggest that different vulnerabilities in intermediate cell types can affect the outcome of tumor suppressor loss in stem cell lineages...
  21. pmc Drosophila Reporter Vectors Compatible with ΦC31 Integrase Transgenesis Techniques and Their Use to Generate New Notch Reporter Fly Lines
    Ben E Housden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    G3 (Bethesda) 2:79-82. 2012
    ..By using these vectors to generate a set of Notch reporter fly lines, we demonstrate their efficacy in reporting the function of gene regulatory elements.
  22. ncbi Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
    D Pan
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Cell 90:271-80. 1997
    b>Notch and the disintegrin metalloprotease encoded by the kuzbanian (kuz) gene are both required for a lateral inhibition process during Drosophila neurogenesis...
  23. pmc Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development
    K M Klueg
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Mol Biol Cell 9:1709-23. 1998
    Delta functions as a cell nonautonomous membrane-bound ligand that binds to Notch, a cell-autonomous receptor, during cell fate specification...
  24. ncbi Dissecting the mechanisms of suppressor of hairless function
    M Furriols
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, United Kingdom
    Dev Biol 227:520-32. 2000
    Suppressor of Hairless [Su(H)] is a DNA-binding protein that is the main intracellular transducer of the Notch signaling pathway in Drosophila...
  25. pmc Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling
    S Ben-Yaacov
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 152:1-13. 2001
    ..The nature of the Wsp mutant phenotypes, coupled with genetic interaction studies, identifies an essential role for Wsp in lineage decisions mediated by the Notch signaling pathway.
  26. ncbi A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila
    Isabel L Torres
    The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Dev Cell 5:547-58. 2003
    ..The anterior-posterior axis is therefore established by a relay mechanism, which propagates polarity from one cyst to the next...
  27. pmc Notch signaling in Drosophila long-term memory formation
    Xuecai Ge
    Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China
    Proc Natl Acad Sci U S A 101:10172-6. 2004
    b>Notch (N) is a cell surface receptor that mediates an evolutionarily ancient signaling pathway to control an extraordinarily broad spectrum of cell fates and developmental processes...
  28. pmc A Drosophila resource of transgenic RNAi lines for neurogenetics
    Jian Quan Ni
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA
    Genetics 182:1089-100. 2009
    ....
  29. pmc Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila
    Yan Song
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 25:2644-58. 2011
    ..Brain CSC-like cells can arise from dedifferentiation of transit-amplifying progenitors upon Notch hyperactivation...
  30. doi bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation
    Evanthia Zacharioudaki
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Department of Biology, University of Crete, Heraklion, Crete, Greece
    Development 139:1258-69. 2012
    ..Expression of E(spl)mγ and m8, but not of dpn, depends on Notch signalling from the GMC/INP daughter to the NB...
  31. ncbi Drosophila dumbfounded: a myoblast attractant essential for fusion
    M Ruiz-Gomez
    Department of Zoology, University of Cambridge, United Kingdom
    Cell 102:189-98. 2000
    ..duf encodes a member of the immunoglobulin superfamily of proteins that is an attractant for fusion-competent myoblasts. It is expressed by founder cells and serves to attract clusters of myoblasts from which myotubes form by fusion...
  32. ncbi An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling
    Leo Tsuda
    Department of Biological Chemistry and Department of Human Genetics, Molecular Biology Institute, Los Angeles, CA 90095, USA
    Cell 110:625-37. 2002
    ..This Notch ligand then induces neighboring cells to become nonneuronal cone cells. ebi and strawberry notch (sno) regulate EGFR-dependent Delta transcription by antagonizing a repressor function of Suppressor of ..
  33. ncbi crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
    U Tepass
    Institut für Entwicklungsphysiologie, Universitat zu Koln, Federal Republic of Germany
    Cell 61:787-99. 1990
    ..The structure and the expression pattern of the protein and the phenotype of mutations indicate a function of crumbs during the development of epithelia, possibly for the establishment and/or maintenance of cell polarity...
  34. ncbi Roles of the Notch gene in Drosophila wing morphogenesis
    J F de Celis
    Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Mech Dev 46:109-22. 1994
    The Notch gene encodes a transmembrane protein that functions as a receptor of intercellular signals in many developmental processes of Drosophila...
  35. ncbi A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny
    H Pi
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan 11529
    Development 128:2699-710. 2001
    ..It has been shown previously that Notch (N) mutations induce formation of supernumerary SOP cells, and transformation from hair and socket cells to ..
  36. ncbi The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium
    Hélène Doerflinger
    The Wellcome Trust Cancer Research UK Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Development 130:3965-75. 2003
    ..Although the direct targets of PAR-1 are unknown, we suggest that it functions by regulating the plus ends, possibly by capping them at the basal cortex...
  37. ncbi Cell proliferation control by Notch signaling in Drosophila development
    M J Go
    Howard Hughes Medical Institute, Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 125:2031-40. 1998
    The Notch receptor mediates cell interactions controlling the developmental fate of a broad spectrum of undifferentiated cells...
  38. ncbi Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling
    Kenji Matsuno
    Department of Biological Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Development 129:1049-59. 2002
    The Notch pathway is an evolutionarily conserved signaling mechanism that is essential for cell-cell interactions...
  39. ncbi fringe and Notch specify polar cell fate during Drosophila oogenesis
    M Grammont
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 128:2243-53. 2001
    fringe encodes a glycosyltransferase that modulates the ability of the Notch receptor to be activated by its ligands. We describe studies of fringe function during early stages of Drosophila oogenesis...
  40. ncbi Multiple levels of Notch signal regulation (review)
    M Baron
    University of Manchester, School of Biological Sciences, UK
    Mol Membr Biol 19:27-38. 2002
    b>Notch is a vitally important signalling receptor controlling cell fate determination and pattern formation in numerous ways during development of both invertebrate and vertebrate species...
  41. ncbi Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis
    A Carmena
    Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma, Madrid, Spain
    Genes Dev 9:2373-83. 1995
    ..Loss-of-function and overexpression phenotypes indicate a role for l'sc in the segregation of muscle progenitors and the formation of the muscle pattern...
  42. ncbi The choice of cell fate in the epidermis of Drosophila
    P Heitzler
    Unité 184 de Biologie Moléculaire, Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
    Cell 64:1083-92. 1991
    ..Failure of this cell communication, as in the mutants Notch (N), Delta, and shaggy, results in most or all of the cells becoming neural...
  43. ncbi Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
    R G Fehon
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06511
    Cell 61:523-34. 1990
    Genetic analyses have raised the possibility of interactions between the gene products of the neurogenic loci Notch and Delta, each of which encodes a transmembrane protein with EGF homology...
  44. ncbi Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 122:359-69. 1996
    ..boundary of the Drosophila wing imaginal disc have distinctive properties and their specification requires Notch activity...
  45. ncbi Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
    F J Diaz-Benjumea
    Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany
    Development 121:4215-25. 1995
    ..Interaction between cells in adjacent compartments establish the organizer. We report here that Serrate and Notch mediate the interaction between dorsal and ventral cells to direct localized expression of Wingless at the D/V ..
  46. ncbi The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs
    S Sotillos
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Madrid, Spain
    Development 124:4769-79. 1997
    ..Moreover, the requirement of kuzbanian for signalling by a ligand-dependent Abruptex receptor, but not by a constitutively activated form of Notch, suggests that kuzbanian is involved in the ..
  47. ncbi The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA
    Mech Dev 74:3-14. 1998
    It has been suggested that lateral specification of cell fate by Notch signaling depends on feedback on Notch (N) and Delta (Dl) transcription to establish reciprocal distributions of the receptor and its ligand at the protein level...
  48. ncbi Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for notch activity in wing margin establishment in Drosophila
    P Ligoxygakis
    Institute of Molecular Biology, Foundation for Research and Technology Department of Biology, University of Crete, Vasilika Vouton, GR 71110, Heraklion, Greece
    Development 126:2205-14. 1999
    A common consequence of Notch signalling in Drosophila is the transcriptional activation of seven Enhancer of split [E(spl)] genes, which encode a family of closely related basic-helix-loop-helix transcriptional repressors...
  49. ncbi neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis
    E Pavlopoulos
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Crete, Greece
    Dev Cell 1:807-16. 2001
    Activation of the Notch (N) receptor involves an intracellular proteolytic step triggered by shedding of the extracellular N domain (N-EC) upon ligand interaction...
  50. ncbi Bre1 is required for Notch signaling and histone modification
    Sarah Bray
    Department of Anatomy, University of Cambridge, Cambridge, CB, UK
    Dev Cell 8:279-86. 2005
    b>Notch signaling controls numerous cell fate decisions during animal development. These typically involve a Notch-mediated switch in transcription of target genes, although the details of this molecular mechanism are poorly understood...
  51. ncbi Notch signaling controls germline stem cell niche formation in the Drosophila ovary
    Xiaoqing Song
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 134:1071-80. 2007
    ..In this study, we show that Notch signaling controls formation and maintenance of the GSC niche and that cap cells help determine the niche size in ..
  52. pmc The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed
    Francisco Jose Gutierrez-Aviño
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas, Universidad Miguel Hernandez, Campus de Sant Joan, Avd Santiago Ramon y Cajal s n Crta Alicante Valencia km 87, Alicante, Apartado 18, E 03550, San Juan de Alicante, Spain
    EMBO Rep 10:1051-8. 2009
    ..In the Drosophila eye, local Notch activation establishes a conserved dorsal-ventral organizer that promotes growth...
  53. ncbi A role for Abl in Notch signaling
    E Giniger
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Neuron 20:667-81. 1998
    Abl is an axonal tyrosine kinase that has yet to be clearly linked to a receptor; Notch is a receptor for which the signaling pathway remains incompletely understood...
  54. ncbi Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Development 126:2083-92. 1999
    ..Pros misexpression is sufficient for the transformation of PIIa to PIIb fate. The expression of Pros in the normal PIIb cell appears to be regulated by Notch signaling.
  55. ncbi UDP-sugar transporter implicated in glycosylation and processing of Notch
    S Goto
    Genetic Strain Research Center, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Nat Cell Biol 3:816-22. 2001
    ..Mutants in the frc gene exhibit phenotypes resembling wingless and Notch mutants...
  56. pmc Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated notch
    Cedric S Wesley
    Department of Microbiology and Molecular Genetics, The University of Vermont, Burlington, Vermont 05405, USA
    Mol Cell Biol 23:5581-93. 2003
    Different amounts of Suppressor of Hairless (SuH)-dependent Notch (N) signaling is often used during animal development to produce two different tissues from a population of equipotent cells...
  57. ncbi Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development
    Shian Jang Yan
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Development 131:285-98. 2004
    ..development, we studied the regulatory network that controls the expression of Serrate (Ser), a ligand for the Notch (N) signaling pathway, which is essential for the development of the Drosophila wing, as well as vertebrate limbs...
  58. pmc The adhesion force of Notch with Delta and the rate of Notch signaling
    Francois Ahimou
    Department of Microbiology and Molecular Genetics, The University of Vermont, VT 05405, USA
    J Cell Biol 167:1217-29. 2004
    b>Notch signaling is repeatedly used during animal development to specify cell fates...
  59. ncbi Notch is required for wingless signaling in the epidermis of Drosophila
    J P Couso
    Department of Zoology, University of Cambridge, England
    Cell 79:259-72. 1994
    Mutations in the Notch (N) gene affect many processes during the development of Drosophila. Some alleles of Notch affect only particular processes, suggesting that the Notch protein (N) has more than one functional domain...
  60. ncbi A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing
    C J Neumann
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 122:3477-85. 1996
    ..report here that the dorsal/ventral organiser is built though a hierarchy of regulatory interactions involving the Notch and wingless signal transduction pathways and the vestigial gene...
  61. ncbi Atonal, rough and the resolution of proneural clusters in the developing Drosophila retina
    M E Dokucu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Development 122:4139-47. 1996
    ..The opposing roles of atonal and rough are not mediated through the Notch pathway, as their expression remains complementary when Notch activity is reduced...
  62. ncbi Muscle patterning and specification in Drosophila
    M Ruiz-Gomez
    Department of Zoology, University of Cambridge, United Kingdom
    Int J Dev Biol 42:283-90. 1998
    ....
  63. ncbi Expression of fringe is down regulated by Gurken/Epidermal Growth Factor Receptor signalling and is required for the morphogenesis of ovarian follicle cells
    D Zhao
    The University of Edinburgh, Institute of Cell and Molecular Biology, Darwin Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    J Cell Sci 113:3781-94. 2000
    ..that is required at other development stages for mediating interactions between dorsal and ventral cells via Notch signalling...
  64. pmc Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis
    H Lopez-Schier
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
    Genes Dev 15:1393-405. 2001
    ..The Notch pathway is required at two stages in this process: first, for the migration of the follicle cells around the germ ..
  65. ncbi Selector and signalling molecules cooperate in organ patterning
    Jennifer Curtiss
    Department of Molecular, Cell and Developmental Biology, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Nat Cell Biol 4:E48-51. 2002
    ..Such enhancers include autoregulatory enhancers of the selector genes themselves, which drive the refinement of expression patterns of selector genes...
  66. ncbi kuzbanian is required cell autonomously during Notch signalling in the Drosophila wing
    Thomas Klein
    Institute for Genetics, University of Cologne, Weyertal 121, 50931 Cologne Germany
    Dev Genes Evol 212:251-5. 2002
    The kuzbanian gene encodes a metalloprotease of the ADAM family that is involved in Notch signalling. However, its precise role is a matter of controversy...
  67. pmc A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
    Jemima Cordle
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nat Struct Mol Biol 15:849-57. 2008
    The Notch receptor and its ligands are key components in a core metazoan signaling pathway that regulates the spatial patterning, timing and outcome of many cell-fate decisions...
  68. doi AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster
    Satoshi Kametaka
    Department of Anatomy and Histology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima 960 1295, Japan
    J Cell Sci 125:634-48. 2012
    ..Furthermore, AP-1-depleted photoreceptor neurons showed an intracellular accumulation of a Notch regulator, Scabrous, and downregulation of Notch by promoting its degradation in the lysosomes...
  69. ncbi Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo
    J B Skeath
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Development 114:939-46. 1992
    ..It appears that one key function of the neurogenic genes is to silence proneural gene expression within the nonsegregating cells of the initial ectodermal clusters, thereby permitting epidermal development...
  70. ncbi Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila
    L Seugnet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, Illkirch, CU de Strasbourg, France
    Development 124:2015-25. 1997
    Segregation of a single neural precursor from each proneural cluster in Drosophila relies on Notch-mediated lateral signalling...
  71. ncbi Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
    K Matsuno
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 124:4265-73. 1997
    The Notch (N) pathway defines an evolutionarily conserved cell signaling mechanism that governs cell fate choices through local cell interactions...
  72. ncbi Segregation of myogenic lineages in Drosophila requires numb
    M Ruiz Gomez
    Department of Zoology, Cambridge, UK
    Development 124:4857-66. 1997
    ..If numb is overexpressed the reverse transformation occurs. Numb acts to block Notch-mediated repression of genes expressed in muscle progenitor cells...
  73. pmc Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells
    M Buescher
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Genes Dev 12:1858-70. 1998
    ..study, we show that binary fate decision of two pairs of sibling neurons is accomplished through the interplay of Notch (N) signaling and the intrinsic fate determinant Numb...
  74. ncbi Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors
    P zur Lage
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 126:3149-57. 1999
    ..defined by the expression of proneural genes (proneural cluster), and neural fate is refined to single cells by Notch-Delta lateral inhibitory signalling between the cells...
  75. ncbi Notch responds differently to Delta and Wingless in cultured Drosophila cells
    C S Wesley
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 275:9099-101. 2000
    b>Notch, a cell surface receptor, is required for producing different types of cells during development of Drosophila melanogaster...
  76. ncbi Fringe-dependent notch activation and tramtrack function are required for specification of the polar cells in Drosophila oogenesis
    Cassandra Althauser
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Dev Dyn 232:1013-20. 2005
    ..b>Notch signaling is required for specification of a precursor group containing both stalk and polar cells...
  77. ncbi Notch and affinity boundaries in Drosophila
    Héctor Herranz
    ICREA and Institut de Recerca Biomedica, Parc Cientific de Barcelona, Josep Samitier, Barcelona, Spain
    Bioessays 28:113-6. 2006
    ..Cells in adjacent compartments do not mix. Cell interactions mediated by Notch-family receptors have been implicated in the specification of these compartment boundaries...
  78. pmc Molecular separation of two signaling pathways for the receptor, Notch
    Maude Le Gall
    Axon Guidance and Neural Connectivity Unit, Basic Neuroscience Program, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health, Bldg 37, Rm 1016, 37 Convent Drive, Bethesda, MD 20892, USA
    Dev Biol 313:556-67. 2008
    b>Notch is required for many aspects of cell fate specification and morphogenesis during development, including neurogenesis and axon guidance...
  79. pmc Notch mRNA expression in Drosophila embryos is negatively regulated at the level of mRNA 3' processing
    Andrew K Shepherd
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, United States of America
    PLoS ONE 4:e8063. 2009
    b>Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity...
  80. pmc Notch and delta mRNAs in early-stage and mid-stage drosophila embryos exhibit complementary patterns of protein-producing potentials
    Andrew Shepherd
    Department of Biology, University of Vermont, Burlington, Vermont 05405, USA
    Dev Dyn 239:1220-33. 2010
    b>Notch and Delta proteins generate Notch signaling that specifies cell fates during animal development...
  81. ncbi Notch is required for successive cell decisions in the developing Drosophila retina
    R L Cagan
    Department of Biology, Princeton University, New Jersey 08544 1003
    Genes Dev 3:1099-112. 1989
    Mutations in the Notch locus affect a variety of developmental decisions in Drosophila. In this paper, we examine the role of Notch in the developing retina...
  82. ncbi Numb antagonizes Notch signaling to specify sibling neuron cell fates
    E P Spana
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Neuron 17:21-6. 1996
    ..The Drosophila MP2 precursor divides asymmetrically to generate the dMP2/vMP2 interneurons. Delta-Notch signaling is required to specify vMP2 fate, whereas the localized determinant Numb is segregated into dMP2 and is ..
  83. pmc scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
    Anthony M Brumby
    Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    EMBO J 22:5769-79. 2003
    ..In contrast, when oncogenic Ras or Notch is expressed within the scribble mutant clones, cell death is prevented and neoplastic tumors develop...
  84. ncbi Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation
    Tadashi Sakata
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Curr Biol 14:2228-36. 2004
    Ligand-induced proteolytic cleavage and internalization of the plasma membrane receptor Notch leads to its activation. Ligand-independent, steady-state internalization of Notch, however, does not lead to activation...
  85. ncbi Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal in Drosophila
    D L Shellenbarger
    Dev Biol 62:432-46. 1978
  86. ncbi The involvement of the Notch locus in Drosophila oogenesis
    T Xu
    Howard Hughes Medical Institute, Yale University, Department of Cell Biology, New Haven, CT 06536 0812
    Development 115:913-22. 1992
    The Notch gene in Drosophila encodes a transmembrane protein with homology to EGF that, in a variety of tissues, appears to mediate cell interactions necessary for cell fate choices...
  87. ncbi Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor
    I Rebay
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06511
    Cell 67:687-99. 1991
    The neurogenic loci Notch and Delta, which both encode EGF-homologous transmembrane proteins, appear to function together in mediating cell-cell communication and have been shown to interact at the cell surface in vitro...
  88. ncbi Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila
    P Simpson
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg
    Development 109:509-19. 1990
    ..The molecular nature of the protein products of the neurogenic genes is consistent with this idea...
  89. ncbi Neurogenic and antineurogenic effects from modifications at the Notch locus
    J Palka
    Department of Zoology, University of Washington, Seattle 98195
    Development 109:167-75. 1990
    ..We report here that, in the development of the adult peripheral nervous system, the Abruptex alleles of Notch have the opposite phenotype, namely an underproduction of sensory organs or sensilla...
  90. pmc Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors
    S Kidd
    Mol Cell Biol 6:3094-108. 1986
    The Notch locus is essential for proper differentiation of the ectoderm in Drosophila melanogaster. Notch corresponds to a 37-kilobase transcription unit that codes for a major 10.4-kilobase polyadenylated RNA...
  91. ncbi Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum
    F Schweisguth
    Institut Jacques Monod, CNRS Université Paris VII, France
    Development 121:1875-84. 1995
    ..Second, Su(H) mutant SOPs produced neuron-like cells, consistent with a late defect in Notch (N) signalling...
  92. ncbi canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila
    H Miyamoto
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Genes Dev 9:612-25. 1995
    ..Flies doubly mutant for cnomis1 and scabrous1 (sca1) and those for cnomis1 and the split (spl) allele of Notch (N) always have rumpled wings curved downward...
  93. ncbi Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development
    P J Kooh
    Howard Hughes Medical Institute, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202
    Development 117:493-507. 1993
    Delta and Notch function are required for cell fate specification in numerous tissues during embryonic and postembryonic Drosophila development...
  94. ncbi An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye
    M E Fortini
    Department of Cell Biology, Yale University, New Haven, Connecticut 06536
    Nature 365:555-7. 1993
    The Notch locus of Drosophila melanogaster encodes a 2,703-amino-acid transmembrane protein required for a variety of developmental processes, including neurogenesis, oogenesis and ommatidial assembly...
  95. ncbi The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta
    D Doherty
    Howard Hughes Medical Institute and the Department of Biochemistry, University of California, San Francisco 94143 0724, USA
    Development 124:3881-93. 1997
    ..we demonstrate that ectopically expressed big brain acts synergistically with ectopically expressed Delta and Notch, providing the first evidence that big brain may function by augmenting the activity of the Delta-Notch pathway...
  96. ncbi Requirement for dynamin during Notch signaling in Drosophila neurogenesis
    L Seugnet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    Dev Biol 192:585-98. 1997
    ..Singling out of a unique neural precursor from a group of equivalent cells, during Drosophila neurogenesis, involves Notch-mediated lateral signaling...
  97. pmc Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
    S Kidd
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021 6399 USA
    Genes Dev 12:3728-40. 1998
    b>Notch, a transmembrane protein found in a wide range of organisms, is a component of a pathway that mediates cell-fate decisions that involve intercellular communication...
  98. ncbi An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila
    V Zecchini
    Department of Zoology University of Cambridge Cambridge, CB2 3EJ, UK
    Curr Biol 9:460-9. 1999
    The Drosophila Notch protein is a receptor that controls cell fate during embryonic development, particularly in lateral inhibition, a process that acts on groups of cells that share a particular developmental potential to restrict the ..
  99. ncbi Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer
    M E Fortini
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Genet 16:161-7. 2000
    ..With the advent of complete genomic sequencing on the horizon, Drosophila will continue to be an outstanding model system in which to unravel the complexities, causes and treatments for human neural degeneration...
  100. ncbi The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 104:699-708. 2001
    ..Through proliferation and survival control, such signals couple the total number of uncommitted cells being generated to the neural patterning of the retina...
  101. ncbi Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye
    Y Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Biol 11:330-8. 2001
    ..inhibition requires the Notch intracellular domain to coactivate Su(H)-mediated transcription of the Enhancer-of-split Complex...

Research Grants43

  1. HEDGEHOG SIGNALING IN DEVELOPMENT AND DISEASE
    Thomas Kornberg; Fiscal Year: 2009
    ....
  2. Amyloid Precursor Protein Signaling
    Mark Bothwell; Fiscal Year: 2006
    ..It is proposed that APP resembles the receptor Notch in possessing two alternative signaling pathways - one propagated from the membrane-resident receptor and another ..
  3. Nogo Receptor Signaling and Function
    Mark Bothwell; Fiscal Year: 2007
    ..Effects of these manipulations on axonal targeting will be assessed by injecting the fluorescent marker Dil into embryos to allow microscopic imaging of axon trajectories. ..
  4. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
    ..This work will provide insight into the role of these proteins in neurodegenerative diseases and development. ..
  5. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    This grant examines the role of Notch signaling in cerebellar cell specification...
  6. INTERACTION OF K PROTEIN WITH PROTEIN KINASES
    Karol Bomsztyk; Fiscal Year: 2007
    ..Exploring the mechanisms and rote of K protein mitogen-induced recruitment to inducible gene loci will provide new insight into the regulation of gene expression. ..
  7. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. [unreadable] [unreadable]..
  8. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
    ..Our work in Drosophila on the mechanisms and targets of these regulators' action will provide insight as to the underlying causes of these diseases and will help to reveal potential therapies. ..
  9. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..We are particularly interested in the Hairy/Enhancer of split/Deadpan (HES) family of basic-Helix-Loop-Helix (bHLH) proteins that function as dedicated repressors important in ..
  10. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  11. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  12. The enhancer of rudimentary gene
    STUART TSUBOTA; Fiscal Year: 2002
    ..The expression data of e(r) suggest that mutants may be embryonic lethals. If this is the case, the mutants will be analyzed for cellular defects in the embryo that that will help uncover the normal function of e(r). ..
  13. Role of the Archipelago gene in Drosophila tracheal morphogenesis
    Kenneth H Moberg; Fiscal Year: 2010
    ..Thus, we hypothesize that ago plays an important role in the homeostatic mechanisms that restrain tracheal branching. Our goal in Specific Aim 3 is to define this role and elucidate its molecular basis. ..
  14. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
    ..Most asymmetric divisions in Drosophila and vertebrate nervous systems depend on the opposing activities of the Notch signaling pathway and the cytoplasmic determinant Numb...
  15. THE DROSOPHILA DORSAL AIR SACS, A MODEL SYSTEM FOR LUNG DEVELOPMENT
    Thomas B Kornberg; Fiscal Year: 2010
    ....
  16. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
  17. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
    ..Such knowledge may point to mechanisms that cause brain cells to revert to less differentiated states in brain tumors or degenerate in neurological disorders. ..
  18. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  19. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....
  20. COMPARATIVE MOLECULAR POPULATION GENETICS OF DROSOPHILA
    Charles F Aquadro; Fiscal Year: 2010
    ..Localized resequencing of three of these regions has uncovered positive selection affecting synonymous sites (at Notch), amino acid sequence diversification (at CG18508) and two selective sweeps putatively associated with ..
  21. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
    ..Suppressor of Hairless (another important regulator of midline glial development and the downstream effector of Notch signaling) will be analyzed using genetic and molecular techniques...
  22. NEUROTROPHIN RECEPTOR INTERACTIONS
    Mark Bothwell; Fiscal Year: 2004
    ..The patterns of developmental expression of P75/NTR, NRH1 and NRH2 will be examined in Xenopus and mice, to assess whether the opportunity for functional interactions exist. ..
  23. NOTCH SIGNALING IN MAMMALIAN CELLS
    GERALDINE WEINMASTER; Fiscal Year: 2002
    DESCRIPTION: Members of the Notch/LIN-12/GLP-1 family of transmembrane receptors are believed to play a central role in development by regulating cell-fate decisions in invertebrates...
  24. LAMININ GENE EXPRESSION IN GLOMERULAR CELLS
    Karol Bomsztyk; Fiscal Year: 2002
    ..If the silencer can been narrowed down to 10-20 bp, then mutations can be made in the context of the -233/-15 fragment to abolish silencer activity. He will also test the silencer effect on heterologous promoters (SV40). ..
  25. NOTCH SIGNALING IN HEMATOPOIETIC CELLS
    THOMAS KADESCH; Fiscal Year: 2002
    DESCRIPTION (Adapted from Investigator's Abstract): This resubmission focuses on signaling by Notch, a transmembrane receptor that influences cell fate choices in lower eukaryotes and which can alter proper development of particular cell ..
  26. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
    ..These studies will help understand pathways that govern the lineage elaboration in the Drosophila CNS as well as in other eukaryotic organisms including humans. ..
  27. TRANSCRIPTIONAL DETERMINANTS OF B LYMPHOCYTES
    THOMAS KADESCH; Fiscal Year: 2002
    ....
  28. Developing a mouse model to study Notch furin processing
    GERALDINE WEINMASTER; Fiscal Year: 2002
    The Notch cell surface receptor is activated by ligands expressed on the surface of neighboring cells to direct correct cell specification, patterning, and morphogenesis within virtually all metazoan organisms studied to date...
  29. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  30. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2003
    ..The techniques proposed here offer a general method for turning on gene activity both spatially and temporally in Drosophila. ..
  31. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  32. INVESTIGATING A ROLE FOR NOTCH SIGNALING IN ANGIOGENESIS
    GERALDINE WEINMASTER; Fiscal Year: 2001
    b>Notch signaling has been implicated in a wide variety of processes from cell fate decisions, tissue patterning and morphogenesis to human disease...
  33. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
    ....
  34. A Drosophilia Model of Amyotrophic Lateral Schlerosis
    Stephen Jackson; Fiscal Year: 2004
    ..Results from this work should clarify the normal cellular role of the ALS2 gene and may reveal strategies for treatment of ALS disease. ..
  35. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    In this proposal, we investigate the mechanisms and implications of the regulation of the Notch signaling pathway by fringe...
  36. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
    ..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
  37. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ....
  38. Understanding cell biology of Delta-Notch interactions
    GERALDINE WEINMASTER; Fiscal Year: 2006
    b>Notch signaling regulates a wide variety of mammalian cell fates and processes...
  39. CENTER FOR DEVELOPMENT OF ANTI-SPERM CONTRACEPTIVES
    Paul Primakoff; Fiscal Year: 2006
    ..Thus, we have proposed an expansion of our target list in spermatogenesis, increasing our scope and chances of developing new products for birth control. ..
  40. ELECTRONIC ATLAS OF FETAL BRAIN GENE EXPRESSION
    Tom Strachan; Fiscal Year: 2004
    ..abstract_text> ..
  41. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  42. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    Transcriptional repression is emerging as an important feature of developmental processes. The Hairy/E(spl) family of bHLH proteins appear to function as dedicated repressors...
  43. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..