Mef2

Summary

Gene Symbol: Mef2
Description: Myocyte enhancer factor 2
Alias: 22.21, BEST:SD04091, CG1429, D-MEF2, D-Mef2, D-mef2, DMEF-2, DMEF2, DMedf2, DMef-2, DMef2, Dmef, Dmef-2, Dmef2, Dmel\CG1429, MEF-2, MEF2, Mef, Mef-2, SD04091, dMEF2, dMEf2, dMef2, dmef2, l(2)46CFr, mb247, mef, mef-2, mef2, mef2c, CG1429 gene product from transcript CG1429-RF, CG1429-PA, CG1429-PB, CG1429-PC, CG1429-PD, CG1429-PF, CG1429-PG, CG1429-PH, DMEF2, Drosophila-myocyte enhancer factor 2, Mef2-PA, Mef2-PB, Mef2-PC, Mef2-PD, Mef2-PF, Mef2-PG, Mef2-PH, Myocyte-enhancer factor 2, Myocyte-enhancer factor-2, complementation group C, drosophila myocyte-specific enhancer factor 2, group C, myocyte enhancer factor 2, myocyte enhancer factor-2, myocyte enhancing factor 2, myocyte-specific enhancer factor 2
Species: fruit fly

Top Publications

  1. ncbi MEF2: a central regulator of diverse developmental programs
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Development 134:4131-40. 2007
  2. ncbi Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones
    A Prokop
    Department of Zoology, University of Cambridge, United Kingdom
    Neuron 17:617-26. 1996
  3. ncbi Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules
    H T Nguyen
    Department of Medicine, Division of Cardiology, Forchheimer G42, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Dev Biol 204:550-66. 1998
  4. pmc zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesis
    A A Postigo
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 19:7255-63. 1999
  5. ncbi The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity
    S Zaffran
    Laboratoire de Genetique et Physiologie du Developpement, UMR 9943 CNRS Université, IBDM CNRS INSERM, Universite de la Mediterranee, Campus de Luminy Case, Marseille, France
    Development 124:2087-98. 1997
  6. pmc Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster
    Jianbo Wang
    Department of Biochemistry and Molecular Biology, Box 117, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell Biol 25:4200-10. 2005
  7. pmc Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 19:2343-54. 2005
  8. ncbi Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors
    E N Olson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 172:2-14. 1995
  9. pmc D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis
    B Lilly
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Proc Natl Acad Sci U S A 91:5662-6. 1994
  10. ncbi The wingless signaling pathway is directly involved in Drosophila heart development
    M Park
    Department of Biology, University of Michigan, Ann Arbor, Michigan, 48109 1048, USA
    Dev Biol 177:104-16. 1996

Scientific Experts

Detail Information

Publications136 found, 100 shown here

  1. ncbi MEF2: a central regulator of diverse developmental programs
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Development 134:4131-40. 2007
    The myocyte enhancer factor 2 (MEF2) transcription factor acts as a lynchpin in the transcriptional circuits that control cell differentiation and organogenesis...
  2. ncbi Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones
    A Prokop
    Department of Zoology, University of Cambridge, United Kingdom
    Neuron 17:617-26. 1996
    ..Myoblasts also fail to fuse but still attract appropriate innervation in mef2 mutant embryos...
  3. ncbi Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules
    H T Nguyen
    Department of Medicine, Division of Cardiology, Forchheimer G42, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Dev Biol 204:550-66. 1998
    The function of the Drosophila mef2 gene, a member of the MADS box supergene family of transcription factors, is critical for terminal differentiation of the three major muscle cell types, namely somatic, visceral, and cardiac...
  4. pmc zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesis
    A A Postigo
    Division of Molecular Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 19:7255-63. 1999
    ..One potential target of zfh-1 in somatic myogenesis could be the myogenic factor mef2. mef2 is known to be regulated by the transcription factor twist, and we show here that zfh-1 binds to sites in the ..
  5. ncbi The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity
    S Zaffran
    Laboratoire de Genetique et Physiologie du Developpement, UMR 9943 CNRS Université, IBDM CNRS INSERM, Universite de la Mediterranee, Campus de Luminy Case, Marseille, France
    Development 124:2087-98. 1997
    ..The properties of the how gene described herein suggest that this gene participates in the control of expression of as yet unidentified target mRNAs coding for proteins essential to cardiac and muscular activity...
  6. pmc Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster
    Jianbo Wang
    Department of Biochemistry and Molecular Biology, Box 117, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell Biol 25:4200-10. 2005
    ..Such findings implicate Toll as a critical cell adhesion molecule in the alignment and migration of cardioblasts during dorsal vessel morphogenesis...
  7. pmc Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth
    Nicholas S Sokol
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 19:2343-54. 2005
    ..The expression of DmiR-1 is controlled by the Twist and Mef2 transcription factors...
  8. ncbi Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors
    E N Olson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 172:2-14. 1995
  9. pmc D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis
    B Lilly
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Proc Natl Acad Sci U S A 91:5662-6. 1994
    ..We have cloned a protein from Drosophila, termed D-MEF2, that shares extensive amino acid homology with the MADS (MCM1, Agamous, Deficiens, and serum-response factor) ..
  10. ncbi The wingless signaling pathway is directly involved in Drosophila heart development
    M Park
    Department of Biology, University of Michigan, Ann Arbor, Michigan, 48109 1048, USA
    Dev Biol 177:104-16. 1996
    ..In particular, overexpression of dsh can restore heart formation in the absence of wg function. We discuss the possibility that Wg signaling is part of a combinatorial mechanism to specify the cardiac mesoderm...
  11. ncbi A distinct set of founders and fusion-competent myoblasts make visceral muscles in the Drosophila embryo
    B S Martin
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Development 128:3331-8. 2001
    ..These specialisations are revealed in mutant embryos where myoblast fusion fails. In the absence of fusion, founders make mononucleate circular or longitudinal fibres, while their fusion-competent neighbours remain undifferentiated...
  12. ncbi Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation
    J B Weiss
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 107:387-98. 2001
    ..jeb reveals a signaling process in which somatic muscle precursors support the proper migration and differentiation of visceral muscle cells. Later in embryogenesis, jeb is transcribed in neurons and Jeb protein is found in axons...
  13. ncbi Integrating transcriptional and signalling networks during muscle development
    Eileen E Furlong
    Developmental Biology and Gene Expression Programmes, EMBL, Heidelberg, Germany
    Curr Opin Genet Dev 14:343-50. 2004
    ..The integration of additional signalling inputs with localised repression within these competence domains results in diverse transcriptional responses within neighbouring cells, which in turn generates muscle diversity...
  14. pmc Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis
    Ming Ching Wong
    Weill Graduate School of Medical Sciences, Cornell University, New York, NY, USA
    Dev Biol 317:417-29. 2008
    ..revealed a Da repression (REP) domain, which is required for Twi/Da-mediated repression of myogenic genes, such as Dmef2, both in tissue culture and in vivo...
  15. pmc The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner
    Sarada Bulchand
    Temasek Lifesciences Laboratory, National University of Singapore, Singapore, Singapore
    PLoS ONE 5:e9374. 2010
    ..These results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf...
  16. ncbi A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila
    G Ranganayakulu
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 171:169-81. 1995
    The D-mef2 gene encodes a MADS domain transcription factor expressed in differentiated muscles and their precursors in the Drosophila embryo...
  17. ncbi Drosophila MEF2, a transcription factor that is essential for myogenesis
    B A Bour
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Genes Dev 9:730-41. 1995
    b>mef2 encodes the only apparent Drosophila homolog of the vertebrate myocyte-specific enhancer factor 2 (MEF2). We show herein that the Drosophila MEF2 protein is expressed throughout the mesoderm following gastrulation...
  18. ncbi Muscle development: a transcriptional pathway in myogenesis
    M V Taylor
    Department of Zoology, University of Cambridge, UK
    Curr Biol 8:R356-8. 1998
    ..For body wall muscle, a pathway can now be drawn that links the transcription factor Dorsal, inherited from the egg, with the differentiated-muscle protein tropomyosin...
  19. ncbi Independent regulatory elements in the upstream region of the Drosophila beta 3 tubulin gene (beta Tub60D) guide expression in the dorsal vessel and the somatic muscles
    C Damm
    Philipps Universitat Marburg, Germany
    Dev Biol 199:138-49. 1998
    ..This region contains a binding site for the Drosophila myocyte-specific enhancer binding factor 2 (D-MEF2), a MADS-box transcription factor known to be essential for mesoderm development...
  20. ncbi The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision
    M T Su
    Department of Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Development 126:3241-51. 1999
    ..We discuss the combinatorial control mechanisms that specify the EPC cell fate in a spatially precise pattern within the embryo...
  21. pmc Oogenic function of the myogenic factor D-MEF2: negative regulation of the decapentaplegic receptor gene thick veins
    E Y Mantrova
    Center for Molecular and Structural Biology, Department of Cell Biology and Anatomy, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, SC 29425, USA
    Proc Natl Acad Sci U S A 96:11889-94. 1999
    The myogenic factor D-MEF2 is required for the proper differentiation of muscle cells during Drosophila embryogenesis and the correct patterning of indirect flight muscles assembled during later metamorphosis...
  22. pmc The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila
    N Fossett
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:7342-7. 2001
    ..These results indicate that the fly and mouse FOG proteins function similarly in three distinct cellular contexts in Drosophila, but may use different mechanisms to regulate genetic events in blood vs. cardial or eye cell lineages...
  23. ncbi Invertebrate myogenesis: looking back to the future of muscle development
    M K Baylies
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA
    Curr Opin Genet Dev 11:431-9. 2001
    ..Drosophila myogenesis has become a highly informative model for understanding the interplay between the signaling and transcriptional networks that underlie cell-fate specification during embryonic development...
  24. ncbi Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila
    E H Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Dev Cell 1:705-15. 2001
    ..These findings suggest that ANTS functions as an intracellular adaptor protein that relays signals from Dumbfounded to the cytoskeleton during myoblast fusion...
  25. ncbi rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion
    A Rau
    Developmental Biology, Philipps Universitat Marburg, 35032 Marburg, Germany
    Development 128:5061-73. 2001
    ..Transplantation assays of rols mutant mesodermal cells into wild-type embryos show that Rols is required in muscle precursor cells and is essential to recruit fusion-competent myoblasts for myotube formation...
  26. ncbi myoblasts incompetent encodes a zinc finger transcription factor required to specify fusion-competent myoblasts in Drosophila
    Mar Ruiz-Gomez
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, 28049 Madrid, Spain
    Development 129:133-41. 2002
    ..myoblasts fail to express proteins characteristic of the general pathway of myogenesis such as myosin and Dmef2. Thus myoblasts incompetent appears to function specifically in the general pathway of myogenesis to control the ..
  27. ncbi Dynamics of heart differentiation, visualized utilizing heart enhancer elements of the Drosophila melanogaster bHLH transcription factor Hand
    Julia Sellin
    Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie, Barbarastrasse 11, 49069 Osnabruck, Germany
    Gene Expr Patterns 6:360-75. 2006
    ....
  28. pmc Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration
    EDGARDO SANTIAGO-MARTINEZ
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane West, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:12441-6. 2006
    ..We propose a model in which Slit has a dual role during assembly of the linear heart tube, functioning to regulate both cell positioning and adhesive interactions between migrating cardiac precursor cells...
  29. ncbi A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion
    Sangjoon Kim
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Cell 12:571-86. 2007
    ..These studies reveal a surprising cell-type specificity of Sltr-mediated actin polymerization in myoblast fusion, and demonstrate that targeted exocytosis of prefusion vesicles is a critical step prior to plasma membrane fusion...
  30. pmc The Him gene reveals a balance of inputs controlling muscle differentiation in Drosophila
    David Liotta
    Cardiff School of Biosciences, Cardiff University Main Building, Cardiff CF10 3TL, United Kingdom
    Curr Biol 17:1409-13. 2007
    Tissue development requires the controlled regulation of cell-differentiation programs. In muscle, the Mef2 transcription factor binds to and activates the expression of many genes and has a major positive role in the orchestration of ..
  31. ncbi Drosophila MEF2 is regulated by twist and is expressed in both the primordia and differentiated cells of the embryonic somatic, visceral and heart musculature
    M V Taylor
    Department of Zoology, University of Cambridge, England
    Mech Dev 50:29-41. 1995
    ..Drosophila has a single MEF2 gene, DMEF2, that is alternatively spliced to produce different transcripts and which is expressed in the mesodermal ..
  32. ncbi Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila
    B Lilly
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Science 267:688-93. 1995
    Members of the myocyte enhancer binding factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, and serum response factor) box transcription factors are expressed in the skeletal, cardiac, and smooth muscle lineages of vertebrate and ..
  33. pmc D-mef2: a Drosophila mesoderm-specific MADS box-containing gene with a biphasic expression profile during embryogenesis
    H T Nguyen
    Department of Cardiology, Children s Hospital, Boston, MA 02115
    Proc Natl Acad Sci U S A 91:7520-4. 1994
    We have identified a mesoderm-specific Drosophila gene, designated D-mef2. The encoded protein contains the MADS- and MEF2-specific domains, which are characteristic of the myocyte-specific enhancer factor 2 (MEF2) family of transcription ..
  34. pmc Myocyte-specific enhancer factor 2 acts cooperatively with a muscle activator region to regulate Drosophila tropomyosin gene muscle expression
    M H Lin
    Department of Biochemistry, University of Illinois College of Medicine, Chicago 60612, USA
    Proc Natl Acad Sci U S A 93:4623-8. 1996
    b>MEF2 (myocyte-specific enhancer factor 2) is a MADS box transcription factor that is thought to be a key regulator of myogenesis in vertebrates...
  35. ncbi heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo
    S Gisselbrecht
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:3003-17. 1996
    ..These studies establish that Htl signaling provides a vital connection between initial formation of the embryonic mesoderm in Drosophila and subsequent cell-fate specification within this germ layer...
  36. pmc D-mef2 is a target for Tinman activation during Drosophila heart development
    K Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    EMBO J 16:515-22. 1997
    The NK-type homeobox gene tinman and the MADS box gene D-mef2 encode transcription factors required for the development and differentiation of the Drosophila heart, and closely related genes regulate cardiogenesis in vertebrates...
  37. ncbi Ectopic expression of MEF2 in the epidermis induces epidermal expression of muscle genes and abnormal muscle development in Drosophila
    M H Lin
    Department of Biochemistry M C536, University of Illinois College of Medicine, Chicago 60612, USA
    Dev Biol 182:240-55. 1997
    Myocyte-specific enhancer-binding factor 2 (MEF2) is a myogenic regulatory factor in vertebrates and Drosophila...
  38. pmc Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization
    M R Erickson
    Department of Biochemistry and Molecular Biology and Center for Gene Regulation, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Cell Biol 138:589-603. 1997
    ....
  39. ncbi ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors
    K Jagla
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3471-9. 1997
    ..These events result in a diversification of heart cell identities within each segment...
  40. pmc The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis
    R M Cripps
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9148, USA
    Genes Dev 12:422-34. 1998
    b>MEF2 is a MADS-box transcription factor required for muscle development in Drosophila...
  41. ncbi The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2
    R Artero
    Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Science, Cornell University, 1275 York Avenue, New York, New York 10021, USA
    Dev Biol 195:131-43. 1998
    ..Analysis of mbl expression in embryos that are either mutant for Dmef2 or ectopically express Dmef2 places mbl downstream of Dmef2 function in the myogenic differentiation program...
  42. ncbi Heart development in Drosophila and vertebrates: conservation of molecular mechanisms
    R Bodmer
    Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Dev Genet 22:181-6. 1998
    ..By now, there is also evidence that MEF2 transcription factors and TGF-beta signaling have cardiogenic functions in both these systems...
  43. ncbi Combinatorial control of Drosophila mef2 gene expression in cardiac and somatic muscle cell lineages
    K Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Genes Evol 208:382-92. 1998
    The Drosophila mef2 gene encodes a MADS domain transcription factor required for the differentiation of cardiac, somatic, and visceral muscles during embryogenesis and the patterning of adult indirect flight muscles assembled during ..
  44. pmc The heterotrimeric protein Go is required for the formation of heart epithelium in Drosophila
    F Frémion
    Laboratoire de Genetique et Physiologie du Developpement, UMR 6545 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France
    J Cell Biol 145:1063-76. 1999
    ..We predict that bkh might be involved in vesicular traffic of membrane proteins that is responsible for the acquisition of polarity...
  45. ncbi Different levels, but not different isoforms, of the Drosophila transcription factor DMEF2 affect distinct aspects of muscle differentiation
    D Gunthorpe
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 215:130-45. 1999
    ..Drosophila mef2 (Dmef2) has been shown to be required for the differentiation of a variety of distinct muscle types...
  46. ncbi Transcription of the myogenic regulatory gene Mef2 in cardiac, somatic, and visceral muscle cell lineages is regulated by a Tinman-dependent core enhancer
    R M Cripps
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, Texas 75235 9148, USA
    Dev Biol 215:420-30. 1999
    The MADS-box transcription factor MEF2 is expressed specifically in developing cardiac, somatic, and visceral muscle cell lineages during Drosophila embryogenesis and is required for myoblast differentiation and muscle morphogenesis...
  47. ncbi The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila
    K Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 126:5679-88. 1999
    ..factor has been implicated through the analysis of a cardial cell enhancer of the muscle differentiation gene D-mef2. We show that the GATA gene pannier is expressed in the dorsal mesoderm and required for cardial cell formation ..
  48. ncbi A novel Drosophila, mef2-regulated muscle gene isolated in a subtractive hybridization-based molecular screen using small amounts of zygotic mutant RNA
    M V Taylor
    Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 220:37-52. 2000
    ..Two pivotal regulators of mesoderm development and gene expression are Dmef2 and tinman (tin)...
  49. pmc Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion
    B A Bour
    Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16802 USA
    Genes Dev 14:1498-511. 2000
    ..To these ends, we demonstrate that the presence of SNS-expressing cells is absolutely dependent on Notch, and that expression of SNS does not require the myogenic regulatory protein MEF2.
  50. ncbi Genetically distinct cardial cells within the Drosophila heart
    K Gajewski
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 28:36-43. 2000
    ..Further differences in the cells are substantiated by the identification of separable enhancers for D-mef2 gene transcription in the distinct cardioblast sets...
  51. ncbi Characterization of a novel subset of cardiac cells and their progenitors in the Drosophila embryo
    E J Ward
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 127:4959-69. 2000
    ..Furthermore, we demonstrate that numb and sanpodo mediate the asymmetric divisions of the two mixed-lineage heart progenitors noted above...
  52. ncbi Direct regulation of the muscle-identity gene apterous by a Hox protein in the somatic mesoderm
    M Capovilla
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 67084 Strasbourg, France
    Development 128:1221-30. 2001
    ....
  53. ncbi Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration
    S G Kramer
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, 519 Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Science 292:737-40. 2001
    ..A few hours after migration, these same cells change their behavior and require Robo to extend toward Slit-expressing muscle attachment sites. Thus, Slit functions as a chemoattractant to provide specificity for muscle patterning...
  54. ncbi The role of Drosophila mushroom body signaling in olfactory memory
    S E McGuire
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 293:1330-3. 2001
    ..Inactivation of mushroom body signaling through alpha/beta neurons during different phases of memory processing revealed a requirement for mushroom body signaling during memory retrieval, but not during acquisition or consolidation...
  55. ncbi Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells
    M R Molina
    Department of Biology, University of New Mexico, Albuquerque, NM 87131 1091, USA
    Mech Dev 109:51-9. 2001
    ..Furthermore, our experiments define the cellular changes that occur as the larval heart is remodeled into an imaginal structure in an important model organism...
  56. ncbi Drosophila rolling pebbles: a multidomain protein required for myoblast fusion that recruits D-Titin in response to the myoblast attractant Dumbfounded
    S D Menon
    Institute of Molecular and Cell Biology, 117609, Singapore
    Dev Cell 1:691-703. 2001
    ..Rols7 integrates the initial event of myoblast attraction with the downstream event of myotube structural organization by linking Duf to D-Titin...
  57. ncbi Drosophila Lame duck, a novel member of the Gli superfamily, acts as a key regulator of myogenesis by controlling fusion-competent myoblast development
    H Duan
    Department of Medicine Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 128:4489-500. 2001
    ..Embryos that lack lmd function show a loss of expression of two key differentiation and fusion genes, Mef2 and sticks-and-stones, in fusion-competent myoblasts and are completely devoid of multinucleate muscle fibers...
  58. ncbi Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages
    Kathleen K Kelly
    Department of Biology, University of New Mexico, Albuquerque, NM 87131 1091, USA
    Mech Dev 110:39-50. 2002
    ..This fragment contained a MEF2 binding site conserved between D...
  59. ncbi A Twist in fate: evolutionary comparison of Twist structure and function
    Irinka Castanon
    Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 287:11-22. 2002
    ..Conserved principles and the molecular mechanisms underlying them are discussed...
  60. ncbi Pericardin, a Drosophila type IV collagen-like protein is involved in the morphogenesis and maintenance of the heart epithelium during dorsal ectoderm closure
    Aymeric Chartier
    Laboratoire de Genetique et Physiologie du Developpement, UMR 6545 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 129:3241-53. 2002
    ..Our results support, for the first time, the function of a collagen-like protein in the coordinated migration of dorsal ectoderm and heart cells...
  61. ncbi The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development
    Claudia Bagni
    European Molecular Biology Laboratory, Heidelberg, D 69117, Germany
    Mech Dev 117:265-8. 2002
    ..Later it is expressed in all muscle lineages including skeletal, visceral and cardiac. Epistatic analysis showed that CF2 expression is dependent on the myogenic factor MEF2.
  62. ncbi Mutations within the conserved MADS box of the D-MEF2 muscle differentiation factor result in a loss of DNA binding ability and lethality in Drosophila
    Trent Nguyen
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Differentiation 70:438-46. 2002
    Members of the myocyte enhancer factor 2 (MEF2) family of transcription factors contain highly conserved sequences within their MADS box and MEF2 domain...
  63. pmc A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster
    Christina E Lorén
    Umeå Center for Molecular Pathogenesis, Umea University, Sweden
    EMBO Rep 4:781-6. 2003
    ..We propose that the main function of Drosophila Alk during early embryogenesis is in visceral mesoderm development...
  64. ncbi Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6
    Elizabeth H Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 114:751-62. 2003
    ..In muscle cells, this fusigenic mechanism is coupled to fusion receptors; in other fusion-competent cell types it may be triggered by different upstream signals...
  65. ncbi Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion
    Camilla Englund
    Umeå Center for Molecular Pathogenesis, Umea University, Umea, S 901 87, Sweden
    Nature 425:512-6. 2003
    ....
  66. ncbi Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
    Lolitika Mandal
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Genet 36:1019-23. 2004
    ..Our findings suggest that there is a close parallel between the molecular mechanisms functioning in the D. melanogaster cardiogenic mesoderm and those functioning in the mammalian aorta-gonadal-mesonephros mesoderm...
  67. ncbi Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling
    Virginia T Cox
    Program in Developmental Biology, Weill Graduate School of Medical Sciences at Cornell University and Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Development 132:713-24. 2005
    ..This dual requirement for Wg provides a paradigm for understanding how one signaling pathway can act over time to create a diverse array of patterning outcomes...
  68. pmc A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila
    Sree Devi Menon
    Temasek Lifesciences Laboratory, National University of Singapore, 1 Research Link, Singapore 117604
    J Cell Biol 169:909-20. 2005
    ..This implicates the Duf-Rols7 positive feedback loop to the occurrence of fusion at specific sites along the membrane and provides a mechanism by which the rate of fusion is controlled...
  69. ncbi Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis
    Zhe Han
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Development 132:3525-36. 2005
    ....
  70. ncbi The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila
    Ingolf Reim
    Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 132:4911-25. 2005
    ..The integration of this new information with previous findings has allowed us to draw a more complete pathway of regulatory events during cardiac induction and differentiation in Drosophila...
  71. ncbi Transcription of Myocyte enhancer factor-2 in adult Drosophila myoblasts is induced by the steroid hormone ecdysone
    TyAnna L Lovato
    Department of Biology, University of New Mexico, Albuquerque, NM 87131 1091, USA
    Dev Biol 288:612-21. 2005
    ..Here, we demonstrate that expression of the muscle differentiation gene Myocyte enhancer factor-2 (Mef2) is normally delayed in twist-expressing adult myoblasts until the end of the third larval instar...
  72. ncbi Slit and Robo control cardiac cell polarity and morphogenesis
    Li Qian
    The Burnham Institute, Center for Neuroscienes and Aging, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 15:2271-8. 2005
    ....
  73. ncbi Slit coordinates cardiac morphogenesis in Drosophila
    Allison MacMullin
    Department of Biology, McMaster University, LSB 429, 1280 Main St W, Hamilton, ON, Canada L8S 4K1
    Dev Biol 293:154-64. 2006
    ..This indicates that Slit participates in adhesion or adhesion signaling during heart development...
  74. pmc A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR
    Rene L Galindo
    Division of Pediatric Pathology, Department of Pathology, Children s Medical Center, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 103:13439-44. 2006
    ....
  75. pmc Alternative requirements for Vestigial, Scalloped, and Dmef2 during muscle differentiation in Drosophila melanogaster
    Hua Deng
    Department of Cell Biology, Department of Biological Sciences, and Department of Medical Genetics, University of Alberta, Edmonton, Canada
    Mol Biol Cell 20:256-69. 2009
    Vertebrate development requires the activity of the myocyte enhancer factor 2 (mef2) gene family for muscle cell specification and subsequent differentiation...
  76. doi Integration of differentiation signals during indirect flight muscle formation by a novel enhancer of Drosophila vestigial gene
    Frederic Bernard
    Equipe Génétique Moléculaire de la Différenciation, Institut Jacques Monod, CNRS Universite Paris Diderot, Paris, France
    Dev Biol 332:258-72. 2009
    ..Moreover, we show that this enhancer is activated by Drosophila Myocyte enhancing factor 2 (MEF2), Scalloped (SD) and VG but repressed by Twist, demonstrating a sensitivity to differentiation in ..
  77. pmc Differential and overlapping functions of two closely related Drosophila FGF8-like growth factors in mesoderm development
    Anna Klingseisen
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Development 136:2393-402. 2009
    ....
  78. pmc A molecular mechanism of temperature sensitivity for mutations affecting the Drosophila muscle regulator Myocyte enhancer factor-2
    TyAnna L Lovato
    Department of Biology, University of New Mexico, Albuquerque, New Mexico 87131
    Genetics 183:107-17. 2009
    ..TS mutations of the myogenic regulator Myocyte enhancer factor-2 (MEF2) in Drosophila arise in the heteroallelic combination Mef2(30-5)/Mef2(44-5)...
  79. doi Combinatorial binding predicts spatio-temporal cis-regulatory activity
    Robert P Zinzen
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Nature 462:65-70. 2009
    ..This data-driven approach does not require previous knowledge of transcription factor sequence affinity, function or expression, making it widely applicable...
  80. pmc Model-based method for transcription factor target identification with limited data
    Antti Honkela
    Department of Information and Computer Science, Aalto University School of Science and Technology, Helsinki, Finland
    Proc Natl Acad Sci U S A 107:7793-8. 2010
    ..chromatin immunoprecipitation (ChIP-chip) and loss-of-function mutant expression data for two TFs, Twist, and Mef2, controlling mesoderm development in Drosophila...
  81. pmc The transcription factor Mef2 is required for normal circadian behavior in Drosophila
    Florence J Blanchard
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 30:5855-65. 2010
    The transcription factor Mef2 has well established roles in muscle development in Drosophila and in the differentiation of many cell types in mammals, including neurons...
  82. pmc Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors
    Fred Bernard
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    Development 137:2633-42. 2010
    ....
  83. pmc Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity
    Paulo M F Cunha
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Genet 6:e1001014. 2010
    ..Mutations in either Myocyte enhancing factor 2 (Mef2) or the zinc-finger transcription factor lame duck (lmd) lead to very similar defects in myoblast ..
  84. doi Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity
    Sarada Bulchand
    Temasek Lifesciences Laboratory, National University of Singapore, Singapore
    J Cell Sci 123:2697-707. 2010
    ..Importantly, Drosophila Myocyte enhancer factor 2 (Mef2), a central myogenic differentiation factor, and how, an RNA binding protein required for ..
  85. doi Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development
    Stefan Bonn
    Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Nat Genet 44:148-56. 2012
    ..This cell type-specific view identifies dynamic enhancer usage, an essential step in deciphering developmental networks...
  86. pmc Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway
    Shaad M Ahmad
    Laboratory of Developmental Systems Biology, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Cell 23:97-111. 2012
    ..This pathway demonstrates how transcription factors integrate diverse developmental processes during organogenesis...
  87. pmc miR-92b regulates Mef2 levels through a negative-feedback circuit during Drosophila muscle development
    Zhimin Chen
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, 109 Zina Pitcher Place, 4029 BSRB, Ann Arbor, MI 48109, USA
    Development 139:3543-52. 2012
    b>Mef2 is the key transcription factor for muscle development and differentiation in Drosophila. It activates hundreds of downstream target genes, including itself...
  88. pmc Integrative analysis of the zinc finger transcription factor Lame duck in the Drosophila myogenic gene regulatory network
    Brian W Busser
    Laboratory of Developmental Systems Biology, National Heart Lung and Blood Institute, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:20768-73. 2012
    ..Collectively, these findings provide insights into the transcriptional codes regulating muscle gene expression and offer a generalizable approach for similar studies in other systems...
  89. ncbi Muscle development. Making Drosophila muscle
    M V Taylor
    Department of Zoology, University of Cambridge, UK
    Curr Biol 5:740-2. 1995
    Analysis of flies with mutations in the gene encoding the D-mef2 transcription factor identifies it as a controller of differentiation in multiple muscle cell types; it is the first such gene to be described.
  90. ncbi Multiple roles for notch in Drosophila myogenesis
    S Fuerstenberg
    Fred Hutchinson Cancer Research Center, Basic Science Division, 1100 Fairview Avenue N, Seattle, Washington 98109, USA
    Dev Biol 201:66-77. 1998
    ..Additionally, Notch is capable of suppressing muscle development nonautonomously by regulating a signal that emanates from the ectoderm...
  91. ncbi Automated sorting of live transgenic embryos
    E E Furlong
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Nat Biotechnol 19:153-6. 2001
    ....
  92. ncbi Muscle differentiation: how two cells become one
    Michael V Taylor
    Cardiff School of Biosciences, Cardiff University, UK
    Curr Biol 12:R224-8. 2002
    ..Future studies will establish the extent to which the molecular mechanisms of myoblast fusion are conserved between Drosophila and other animals, as found in other aspects of myogenesis...
  93. pmc mef2 activity levels differentially affect gene expression during Drosophila muscle development
    Stuart J Elgar
    School of Biosciences, Cardiff University, Main Building, Park Place, Cardiff CF10 3TL, United Kingdom
    Proc Natl Acad Sci U S A 105:918-23. 2008
    ..Muscle differentiation is a well studied paradigm in which the conserved Mef2 transcription factor plays a pivotal role...
  94. pmc Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation
    EDGARDO SANTIAGO-MARTINEZ
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    J Cell Biol 182:241-8. 2008
    ..Our data show that Slit and Robo pathways function in lumen formation as a repulsive signal to antagonize E-Cad-mediated cell adhesion...
  95. ncbi Muscle development and attachment to the epidermis is accompanied by expression of beta 3 and beta 1 tubulin isotypes, respectively
    D Buttgereit
    FB Biologie, Marburg, Germany
    Int J Dev Biol 40:189-96. 1996
    ..Using the beta 1 and beta 3 tubulin isotypes as markers we started to isolate mutants which are disturbed in muscle formation...
  96. ncbi Misexpression of nautilus induces myogenesis in cardioblasts and alters the pattern of somatic muscle fibers
    C A Keller
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Dev Biol 181:197-212. 1997
    ..In summary, we suggest that nautilus induces myogenic differentiation in vivo when ectopically expressed in developing cardioblasts and may affect the myogenic differentiation program of specific muscle fibers...
  97. ncbi Development of larval body wall muscles
    M Bate
    Department of Zoology, University of Cambridge, United Kingdom
    Int Rev Neurobiol 43:25-44. 1999
  98. pmc Genes regulating dendritic outgrowth, branching, and routing in Drosophila
    F B Gao
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California at San Francisco, San Francisco, California 94143 0725, USA
    Genes Dev 13:2549-61. 1999
    ..These findings begin to reveal the molecular mechanisms controlling dendritic morphogenesis...
  99. ncbi The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel
    TyAnna L Lovato
    Department of Biology, University of New Mexico, Albuquerque 87131 1091, USA
    Development 129:5019-27. 2002
    ..These findings for the first time demonstrate a specific involvement for Hox genes in patterning the muscular circulatory system, and suggest a mechanism of broad relevance for animal heart patterning...
  100. ncbi D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm
    Ivan B N Clark
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Dev Biol 294:220-31. 2006
    ..At stage 9, however, D-six4 and tin are both expressed pan-mesodermally. At this stage, tin function is required for full D-six4 expression. This may explain the known requirement for tin in some non-dorsal cell types...
  101. pmc Defective decapentaplegic signaling results in heart overgrowth and reduced cardiac output in Drosophila
    Aaron N Johnson
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    Genetics 176:1609-24. 2007
    ..Our study suggests the existence of a second round of BMP signaling in mammalian heart development and that perhaps defects in this signal play a role in congenital heart defects...

Research Grants11

  1. Regulatory Genomics: BAC-GFP Library of Control Genes
    Eric Davidson; Fiscal Year: 2008
    ..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. ..
  2. Genetic regulation of cell fate in the Drosophila heart
    RICHARD CRIPPS; Fiscal Year: 2009
    ..abstract_text> ..
  3. Development of tissue-specific cell lines in Drosophila
    Amanda Simcox; Fiscal Year: 2009
    ..Subsequent use of the cell lines by individual investigators to study diverse biological problems is expected to impact our understanding of human disease. ..
  4. REGULATORS OF MUSCLE DIFFERENTIATION
    Hanh Nguyen; Fiscal Year: 2004
    ..The mef2 gene, the Drosophila homologue of the vertebrate myocyte specific enhancer factor 2 (MEF2) is expressed in all muscle progenitors and differentiated musculatures...
  5. Genetic Control of Cardiac Cell-Type Specification
    Rolf Bodmer; Fiscal Year: 2005
    ....
  6. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
    ..Our work in Drosophila on the mechanisms and targets of these regulators' action will provide insight as to the underlying causes of these diseases and will help to reveal potential therapies. ..
  7. Biology and biochemistry of Jelly belly signaling
    Joseph Weiss; Fiscal Year: 2008
    ..Analysis of the phenotype of Ptn/Mk mutants in Drosophila will clarify the signaling function of these molecules both with respect to the pathways in which they participate and their functions in those pathways. [unreadable] [unreadable]..
  8. Control of fat accumulation in relation to cardiac function in Drosophila
    Rolf Bodmer; Fiscal Year: 2008
    ..The outcome of these efforts is expected to provide key mechanistic insights into the complex control of fat accumulation and its influence on heart function ..
  9. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....