Mdr65

Summary

Gene Symbol: Mdr65
Description: Multi drug resistance 65
Alias: CG10181, Dmel\CG10181, MDR65, Mdr65A, P-gp, mdr65, CG10181 gene product from transcript CG10181-RA, CG10181-PA, Mdr65-PA, P-glycoprotein, P-glycoprotein65-Dm, multi drug resistance 65, multiple drug resistance 65
Species: fruit fly

Top Publications

  1. doi Abamectin resistance in Drosophila is related to increased expression of P-glycoprotein via the dEGFR and dAkt pathways
    Liang Luo
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
    Insect Biochem Mol Biol 43:627-34. 2013
  2. doi Seizure-sensitivity in Drosophila is ameliorated by dorsal vessel injection of the antiepileptic drug valproate
    Iris C Howlett
    Department of Molecular and Cell Biology, Division of Neurobiology, University of California, Berkeley, Berkeley, California, USA
    J Neurogenet 27:143-50. 2013
  3. pmc Neurodegeneration caused by polyglutamine expansion is regulated by P-glycoprotein in Drosophila melanogaster
    Suman Yadav
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India
    Genetics 195:857-70. 2013
  4. doi RNAi validation of resistance genes and their interactions in the highly DDT-resistant 91-R strain of Drosophila melanogaster
    Kyle J Gellatly
    Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA, United States
    Pestic Biochem Physiol 121:107-15. 2015
  5. doi Expression of polyQ aggregates in Malpighian tubules leads to degeneration in Drosophila melanogaster
    Suman Yadav
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India
    Dev Biol 409:166-80. 2016
  6. pmc Rapid genomic changes in Drosophila melanogaster adapting to desiccation stress in an experimental evolution system
    Lin Kang
    Biocomplexity Institute, Virginia Tech, Blacksburg, VA, 24061, USA
    BMC Genomics 17:233. 2016
  7. pmc Isolation and characterization of Drosophila multidrug resistance gene homologs
    C T Wu
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Mol Cell Biol 11:3940-8. 1991
  8. ncbi Analysis of Mdr50: a Drosophila P-glycoprotein/multidrug resistance gene homolog
    B Gerrard
    Biological Carcinogenesis and Development Program, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genomics 17:83-8. 1993
  9. ncbi Identification of P-glycoprotein/multidrug resistance genes from model organisms
    R Allikmets
    Laboratory of Viral Carcinogenesis, Program Resources Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702
    Leukemia 7:S13-7. 1993
  10. ncbi A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system
    I Nasonkin
    Department of Pediatric, University of Michigan, Ann Arbor, Michigan 48109 0646, USA
    J Biol Chem 274:29420-5. 1999

Scientific Experts

  • D J Begun
  • Suman Yadav
  • Madhu G Tapadia
  • Lin Kang
  • Kyle J Gellatly
  • Liang Luo
  • Iris C Howlett
  • Sara Ricardo
  • Fahima Mayer
  • Sarah Chahine
  • Dau Dayal Aggarwal
  • Pawel Michalak
  • Eugenia Rashkovetsky
  • Abraham B Korol
  • Jeffery J Doherty
  • Weilin Sun
  • J Marshall Clark
  • Kyong Sup Yoon
  • Barry R Pittendrigh
  • Mark A Tanouye
  • Ying jian Sun
  • Yi Jun Wu
  • Roland J Bainton
  • Nasima Mayer
  • Deanna Kroetz
  • Ruth Lehmann
  • Leslie Chinn
  • Michael J O'Donnell
  • Robert L Pinsonneault
  • I Nasonkin
  • S C Lakhotia
  • A Sarniak
  • C Ambrose
  • P M Thomas
  • P Cahill
  • A Alikasifoglu
  • M Cheng
  • M Egan
  • B Gerrard
  • M Dean
  • C Stewart
  • R Allikmets
  • M White
  • C T Wu
  • M S Griffin
  • J M Croop
  • M Budding

Detail Information

Publications15

  1. doi Abamectin resistance in Drosophila is related to increased expression of P-glycoprotein via the dEGFR and dAkt pathways
    Liang Luo
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
    Insect Biochem Mol Biol 43:627-34. 2013
    ..These results suggest that the increased P-gp in resistant flies was regulated by the dEGFR and dAkt pathways and that increased expression of P-gp is an important component of ABM resistance in insects...
  2. doi Seizure-sensitivity in Drosophila is ameliorated by dorsal vessel injection of the antiepileptic drug valproate
    Iris C Howlett
    Department of Molecular and Cell Biology, Division of Neurobiology, University of California, Berkeley, Berkeley, California, USA
    J Neurogenet 27:143-50. 2013
    ..We propose that this method of drug delivery is especially effective when using Drosophila to model human pathologies, especially neurological syndromes...
  3. pmc Neurodegeneration caused by polyglutamine expansion is regulated by P-glycoprotein in Drosophila melanogaster
    Suman Yadav
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India
    Genetics 195:857-70. 2013
    ..These results thus show that P-gp and polyQ interact with each other, and changing P-gp levels can directly affect neurodegeneration. ..
  4. doi RNAi validation of resistance genes and their interactions in the highly DDT-resistant 91-R strain of Drosophila melanogaster
    Kyle J Gellatly
    Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA, United States
    Pestic Biochem Physiol 121:107-15. 2015
    ..and Lcp1), cytochrome P450 monooxygenases (Cyp6g1 and Cyp12d1), and ATP binding cassette transporters (Mdr50, Mdr65, and Mrp1) involved in DDT resistance...
  5. doi Expression of polyQ aggregates in Malpighian tubules leads to degeneration in Drosophila melanogaster
    Suman Yadav
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India
    Dev Biol 409:166-80. 2016
    ....
  6. pmc Rapid genomic changes in Drosophila melanogaster adapting to desiccation stress in an experimental evolution system
    Lin Kang
    Biocomplexity Institute, Virginia Tech, Blacksburg, VA, 24061, USA
    BMC Genomics 17:233. 2016
    ..In this experiment, we analyzed genomes of Drosophila melanogaster from lines evolving under long-term directional selection for increased desiccation resistance in comparison with control (no-selection) lines...
  7. pmc Isolation and characterization of Drosophila multidrug resistance gene homologs
    C T Wu
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Mol Cell Biol 11:3940-8. 1991
    ..This work sets the foundation for the molecular and genetic analysis of mdr homologs in Drosophila melanogaster...
  8. ncbi Analysis of Mdr50: a Drosophila P-glycoprotein/multidrug resistance gene homolog
    B Gerrard
    Biological Carcinogenesis and Development Program, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201
    Genomics 17:83-8. 1993
    ..Mdr50 represents the third MDR homolog identified in Drosophila. Conservation in the position of intervening sequences between Mdr50 and the human MDR genes provides further evidence for their common origin...
  9. ncbi Identification of P-glycoprotein/multidrug resistance genes from model organisms
    R Allikmets
    Laboratory of Viral Carcinogenesis, Program Resources Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702
    Leukemia 7:S13-7. 1993
    ..While the function of these sequences has not been determined, they may prove to be useful for developing a model to study the function of P-glycoproteins...
  10. ncbi A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal system
    I Nasonkin
    Department of Pediatric, University of Michigan, Ann Arbor, Michigan 48109 0646, USA
    J Biol Chem 274:29420-5. 1999
    ..The lack of gene duplication in the Drosophila system provides a unique opportunity for functional studies of SUR using a genetic approach...
  11. ncbi Genetics of alpha-amanitin resistance in a natural population of Drosophila melanogaster
    D J Begun
    Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Patterson Labs, C0930, Austin, TX 78712, USA
    Heredity (Edinb) 85:184-90. 2000
    ..crosses of chromosome III support a role for a naturally occurring polymorphism in a multidrug resistance gene (Mdr65A) in alpha-amanitin resistance...
  12. pmc Expression of mdr49 and mdr65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditions
    Madhu G Tapadia
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Cell Stress Chaperones 10:7-11. 2005
    In situ expression of 2 multidrug resistance genes, mdr49 and mdr65, of Drosophila melanogaster was examined in wild-type third instar larval tissues under physiological conditions and after heat shock or colchicine feeding...
  13. pmc An ABC transporter controls export of a Drosophila germ cell attractant
    Sara Ricardo
    Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York University, 540 First Avenue, New York, NY 10016, USA
    Science 323:943-6. 2009
    ..Components of this unconventional export pathway are highly conserved, suggesting that this pathway may control the production of similarly modified chemoattractants in organisms ranging from yeast to humans...
  14. pmc Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila
    Fahima Mayer
    Department of Anesthesia and Perioperative Care, San Francisco General Hospital, and Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 29:3538-50. 2009
    ..We characterize a fly ATP binding cassette (ABC) transporter, Mdr65, that functions similarly to mammalian xenobiotic BBB transporters and show that varying its levels solely in the ..
  15. doi Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster
    Sarah Chahine
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Insect Physiol 55:927-35. 2009
    ..Increased levels of the protein products which may result from expression of these genes may enhance elimination of toxic compounds such as MTX or its metabolites...