Gene Symbol: Mdr65
Description: Multiple drug resistance 65
Alias: CG10181, Dmel\CG10181, MDR65, Mdr65A, P-gp, mdr65, CG10181-PA, Mdr65-PA, P-glycoprotein, P-glycoprotein65-Dm, multiple drug resistance 65
Species: fruit fly
- Isolation and characterization of Drosophila multidrug resistance gene homologsC T Wu
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
Mol Cell Biol 11:3940-8. 1991..This work sets the foundation for the molecular and genetic analysis of mdr homologs in Drosophila melanogaster...
- Analysis of Mdr50: a Drosophila P-glycoprotein/multidrug resistance gene homologB Gerrard
Biological Carcinogenesis and Development Program, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201
Genomics 17:83-8. 1993..Mdr50 represents the third MDR homolog identified in Drosophila. Conservation in the position of intervening sequences between Mdr50 and the human MDR genes provides further evidence for their common origin...
- Identification of P-glycoprotein/multidrug resistance genes from model organismsR Allikmets
Laboratory of Viral Carcinogenesis, Program Resources Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702
Leukemia 7:S13-7. 1993..While the function of these sequences has not been determined, they may prove to be useful for developing a model to study the function of P-glycoproteins...
- A novel sulfonylurea receptor family member expressed in the embryonic Drosophila dorsal vessel and tracheal systemI Nasonkin
Department of Pediatric, University of Michigan, Ann Arbor, Michigan 48109 0646, USA
J Biol Chem 274:29420-5. 1999..The lack of gene duplication in the Drosophila system provides a unique opportunity for functional studies of SUR using a genetic approach...
- Genetics of alpha-amanitin resistance in a natural population of Drosophila melanogasterD J Begun
Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Patterson Labs, C0930, Austin, TX 78712, USA
Heredity (Edinb) 85:184-90. 2000..crosses of chromosome III support a role for a naturally occurring polymorphism in a multidrug resistance gene (Mdr65A) in alpha-amanitin resistance...
- Expression of mdr49 and mdr65 multidrug resistance genes in larval tissues of Drosophila melanogaster under normal and stress conditionsMadhu G Tapadia
Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
Cell Stress Chaperones 10:7-11. 2005In situ expression of 2 multidrug resistance genes, mdr49 and mdr65, of Drosophila melanogaster was examined in wild-type third instar larval tissues under physiological conditions and after heat shock or colchicine feeding...
- An ABC transporter controls export of a Drosophila germ cell attractantSara Ricardo
Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York University, 540 First Avenue, New York, NY 10016, USA
Science 323:943-6. 2009..Components of this unconventional export pathway are highly conserved, suggesting that this pathway may control the production of similarly modified chemoattractants in organisms ranging from yeast to humans...
- Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in DrosophilaFahima Mayer
Department of Anesthesia and Perioperative Care, San Francisco General Hospital, and Department of Pharmaceutical Chemistry, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 29:3538-50. 2009..We characterize a fly ATP binding cassette (ABC) transporter, Mdr65, that functions similarly to mammalian xenobiotic BBB transporters and show that varying its levels solely in the ..
- Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogasterSarah Chahine
Department of Biology, McMaster University, Hamilton, Ontario, Canada
J Insect Physiol 55:927-35. 2009..Increased levels of the protein products which may result from expression of these genes may enhance elimination of toxic compounds such as MTX or its metabolites...