lea

Summary

Gene Symbol: lea
Description: leak
Alias: CG14347, CG14348, CG5481, CG5574, CT17326, D-Robo2, D-robo2, Dmel\CG5481, ROBO2, Robo 2, Robo-2, Robo2, Robo2 (Lea), anon-EST:Liang-1.75, clone 1.75, dRobo-2, fus4, robo-2, robo2, CG5481-PA, CG5481-PB, Robo2, Roundabout2, SGP cluster fusion defects 4, lea-PA, lea-PB, roundabout 2
Species: fruit fly

Top Publications

  1. ncbi Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 92:205-15. 1998
  2. ncbi Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology
    Wesley B Grueber
    Departments of Physiology and Biochemistry, University of California, San Francisco, Rock Hall, Room GD481, 1550 4th Street, San Francisco, CA 94143, USA
    Development 134:55-64. 2007
  3. pmc Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation
    Caroline Medioni
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique UMR 6216, Universite de la Mediterranee, 13288 Marseille, Cedex 9, France
    J Cell Biol 182:249-61. 2008
  4. ncbi Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity
    Tanja A Godenschwege
    Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 22:3117-29. 2002
  5. ncbi Slit and Robo control cardiac cell polarity and morphogenesis
    Li Qian
    The Burnham Institute, Center for Neuroscienes and Aging, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 15:2271-8. 2005
  6. ncbi Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system
    Marta Zlatic
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Neuron 37:41-51. 2003
  7. pmc Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration
    EDGARDO SANTIAGO-MARTINEZ
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane West, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:12441-6. 2006
  8. ncbi Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
    K Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 32:605-17. 2001
  9. ncbi Regulation of commissural axon pathfinding by slit and its Robo receptors
    Barry J Dickson
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Annu Rev Cell Dev Biol 22:651-75. 2006
  10. ncbi Slit coordinates cardiac morphogenesis in Drosophila
    Allison MacMullin
    Department of Biology, McMaster University, LSB 429, 1280 Main St W, Hamilton, ON, Canada L8S 4K1
    Dev Biol 293:154-64. 2006

Research Grants

  1. Genes Essential To Motor Axon Guidance in Drosophila
    David Van Vactor; Fiscal Year: 2009

Scientific Experts

  • Jill J Weyers
  • Caroline C G Fabre
  • David J Mellert
  • Marta Zlatic
  • Yimiao Ou
  • David L Van Vactor
  • Guy Tear
  • Lee G Fradkin
  • Virginie Orgogozo
  • Emmanuelle Nicolas
  • Barry J Dickson
  • Bharatkumar N Patel
  • John Chen
  • Timothy A Evans
  • Nadine H Soplop
  • EDGARDO SANTIAGO-MARTINEZ
  • Sunita G Kramer
  • Greg J Bashaw
  • Monika Zmojdzian
  • Allison MacMullin
  • J H Simpson
  • Barry G Condron
  • C S Goodman
  • T Kidd
  • Jessica Vanderploeg
  • Junpei Goto
  • Joachim G Schulz
  • S Rajagopalan
  • Bettina Spitzweck
  • Zongzhao Zhai
  • Iwan R Evans
  • Camilla Englund
  • Takeo Katsuki
  • J Roger Jacobs
  • Bess Wayburn
  • Krzysztof Jagla
  • Caroline Medioni
  • Svetla Dimitrova
  • Wesley B Grueber
  • Markus Affolter
  • Li Qian
  • Tereza Kolesnikov
  • Hiroko Sano
  • Haeryun Lee
  • Jessica A Couch
  • Karl G Johnson
  • Rachel Kraut
  • Timothy D Tayler
  • Dhanisha Jhaveri
  • K Brose
  • Annika Lundström
  • Patrick Steigemann
  • Pär Steneberg
  • Linda Parsons
  • Jannette Rusch
  • Michael Piper
  • Christos Samakovlis
  • Carlos Ribeiro
  • Tanja A Godenschwege
  • Zachary Wills
  • K Keleman
  • S G Kramer
  • K Schimmelpfeng
  • L Lourdes Vazquez Paz
  • Yi Shan Cheng
  • Masayuki Koganezawa
  • Emmanuel Caussinus
  • Bassem A Hassan
  • Yoshitaka Mikawa
  • Guido David
  • Daisuke Yamamoto
  • Helga Ceulemans
  • Maria F Baietti
  • Hiroki Ito
  • Ingrid Lohmann
  • Aurelia L Fuchs
  • Will Wood
  • K S Bland
  • V Vivancos
  • G Vogel
  • G J Bashaw
  • J Rusch
  • Marko Brankatschk
  • Nan Hu
  • Helen Skaer
  • Talila Volk
  • Masaki Hiramoto
  • Deepak Ailani
  • Yasushi Hiromi
  • Gaia Tavosanis

Detail Information

Publications65

  1. ncbi Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 92:205-15. 1998
    ..Transgenic rescue experiments reveal that Robo can function in a cell-autonomous fashion. Robo appears to function as the gatekeeper controlling midline crossing...
  2. ncbi Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology
    Wesley B Grueber
    Departments of Physiology and Biochemistry, University of California, San Francisco, Rock Hall, Room GD481, 1550 4th Street, San Francisco, CA 94143, USA
    Development 134:55-64. 2007
    ....
  3. pmc Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation
    Caroline Medioni
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique UMR 6216, Universite de la Mediterranee, 13288 Marseille, Cedex 9, France
    J Cell Biol 182:249-61. 2008
    ..We suggest that this new example of tube formation may be helpful in studying vertebrate heart tube formation and primary vasculogenesis...
  4. ncbi Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity
    Tanja A Godenschwege
    Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 22:3117-29. 2002
    ..that ectopic Robo expression can regulate the growth and guidance of specific motor neuron dendrites, whereas Robo2 and Robo3 have no effect...
  5. ncbi Slit and Robo control cardiac cell polarity and morphogenesis
    Li Qian
    The Burnham Institute, Center for Neuroscienes and Aging, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Biol 15:2271-8. 2005
    ..Here, we report a novel role of the Drosophila slit, robo, and robo2 genes in heart morphogenesis...
  6. ncbi Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system
    Marta Zlatic
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Neuron 37:41-51. 2003
    ....
  7. pmc Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration
    EDGARDO SANTIAGO-MARTINEZ
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane West, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:12441-6. 2006
    ..the role of Slit, an extracellular matrix protein and its transmembrane receptors Roundabout (Robo) and Roundabout2 (Robo2) during morphogenesis of the Drosophila heart tube, a process analogous to early heart formation in ..
  8. ncbi Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
    K Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 32:605-17. 2001
    ..Ectopic expression of Unc5 on CNS axons can elicit either short- or long-range repulsion from the midline. Both short- and long-range repulsion require Netrin function, but only long-range repulsion requires Frazzled...
  9. ncbi Regulation of commissural axon pathfinding by slit and its Robo receptors
    Barry J Dickson
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Annu Rev Cell Dev Biol 22:651-75. 2006
    ..We hope that this review encourages further efforts to tackle these questions, in the expectation that this system will continue to reveal the general principles of axon pathfinding...
  10. ncbi Slit coordinates cardiac morphogenesis in Drosophila
    Allison MacMullin
    Department of Biology, McMaster University, LSB 429, 1280 Main St W, Hamilton, ON, Canada L8S 4K1
    Dev Biol 293:154-64. 2006
    ..The cardial cells of the developing heart express both Slit and Robo2. This is the first report of coincident expression of a Robo and its ligand...
  11. ncbi Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration
    S G Kramer
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, 519 Life Sciences Addition, University of California, Berkeley, CA 94720, USA
    Science 292:737-40. 2001
    ..A few hours after migration, these same cells change their behavior and require Robo to extend toward Slit-expressing muscle attachment sites. Thus, Slit functions as a chemoattractant to provide specificity for muscle patterning...
  12. ncbi Crossing the midline: roles and regulation of Robo receptors
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Neuron 28:767-77. 2000
    ..Robo levels are in turn regulated by Comm. Here, we show that the Slit receptors Robo2 and Robo3 ensure the fidelity of this crossing decision: rare crossing errors occur in both robo2 and robo3 single ..
  13. ncbi Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
    G J Bashaw
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 101:703-15. 2000
    ..A mutant form of Robo that interferes with Ena binding is partially impaired in Robo function, while a mutation in a conserved cytoplasmic tyrosine that can be phosphorylated by Abl generates a hyperactive Robo receptor...
  14. ncbi Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position
    J H Simpson
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, 519 LSA, University of California, Berkeley CA 94720, USA
    Cell 103:1019-32. 2000
    ..Medial axons express only Robo, intermediate axons express Robo3 and Robo, while lateral axons express Robo2, Robo3, and Robo...
  15. ncbi Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance
    J H Simpson
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 28:753-66. 2000
    ..Here we show that the Drosophila genome encodes three Robo receptors and that Robo and Robo2 have distinct functions, which together control repulsive axon guidance at the midline...
  16. ncbi Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 103:1033-45. 2000
    ..In this long-range function, Slit signals through the receptors Robo2 and Robo3...
  17. pmc Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation
    EDGARDO SANTIAGO-MARTINEZ
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    J Cell Biol 182:241-8. 2008
    ..Our data show that Slit and Robo pathways function in lumen formation as a repulsive signal to antagonize E-Cad-mediated cell adhesion...
  18. pmc Midline crossing by gustatory receptor neuron axons is regulated by fruitless, doublesex and the Roundabout receptors
    David J Mellert
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Development 137:323-32. 2010
    ....
  19. pmc Drosophila serotonergic varicosities are not distributed in a regular manner
    John Chen
    Department of Biology, University of Virginia, Charlottesville, 22903, USA
    J Comp Neurol 515:441-53. 2009
    ..In addition, the pattern breaks down when serotonergic branches of adjacent segments invade each other's territory. The pattern is similar to those described by a power law...
  20. pmc Integrins are required for cardioblast polarisation in Drosophila
    Jessica Vanderploeg
    Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
    BMC Dev Biol 12:8. 2012
    ..Here we characterise the requirement of Integrins in a genetic model of vasculogenesis, the formation of the heart in Drosophila...
  21. pmc Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels
    Joachim G Schulz
    Laboratory of Glycobiology and Developmental Genetics, Katholieke Universiteit Leuven, Herestraat 49 bus 602, KU Leuven, Leuven 3000, Belgium
    EMBO Rep 12:1039-46. 2011
    ..Although the branch-specific phenotype of sdc mutants resembles those seen in the absence of Slit/Robo2 signalling, genetic interaction experiments indicate that Sdc also helps to suppress Slit/Robo2 signalling...
  22. pmc Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems
    Timothy A Evans
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Biol 363:266-78. 2012
    ..In Drosophila, Robo and Robo2 promote midline repulsion, while Robo2 and Robo3 specify the position of longitudinal axon pathways...
  23. pmc Roundabout is required in the visceral mesoderm for proper microvillus length in the hindgut epithelium
    Nadine H Soplop
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854 8020, USA
    Dev Dyn 241:759-69. 2012
    ..In this study we examined Roundabout signaling in the Drosophila embryonic hindgut...
  24. pmc A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway
    Jill J Weyers
    Department of Biology, Johns Hopkins University, 3400 N Charles St, Baltimore, MD, USA
    Dev Biol 353:217-28. 2011
    ..Our findings shed light on the complexities of gonadogenesis and the genetic regulation required for proper organ formation...
  25. doi Cellular analysis of newly identified Hox downstream genes in Drosophila
    Zongzhao Zhai
    BIOQUANT Center, Cluster of Excellence CellNetworks, Heidelberg, University of Heidelberg, Im Neuenheimer Feld 267, D 69120 Heidelberg, Germany
    Eur J Cell Biol 89:273-8. 2010
    ....
  26. doi Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor
    Junpei Goto
    Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai 980 8577, Japan
    J Neurosci 31:5454-9. 2011
    ..The present results suggest that Hb is essential for male-typical shaping of the contralateral neurites by Fru...
  27. pmc Mechanosensilla in the adult abdomen of Drosophila: engrailed and slit help to corral the peripheral sensory axons into segmental bundles
    Caroline C G Fabre
    Department of Zoology, University of Cambridge, Cambridge, UK
    Development 137:2885-94. 2010
    ..We conclude that, during normal development, gradients of Slit protein repel axons away from compartment boundaries - in consequence, the bristles from each segment send their nerves to the CNS in separated sets...
  28. doi LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo
    Bess Wayburn
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 136:3607-15. 2009
    ..Taken together, our data suggest a novel mechanism by which muscles are targeted towards tendon cells as a result of LRT-Robo interactions. This mechanism may apply to the Robo-dependent migration of a wide variety of cell types...
  29. doi Slit and Robo regulate dendrite branching and elongation of space-filling neurons in Drosophila
    Svetla Dimitrova
    Dendrite Differentiation, Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Munich, Germany
    Dev Biol 324:18-30. 2008
    ..We propose that Slit, through Robo, provides an extrinsic signal to coordinate the growth rate and the branching level of space-filling neurons, thus allowing them to appropriately cover their target field...
  30. ncbi Roundabout gene family functions during sensory axon guidance in the drosophila embryo are mediated by both Slit-dependent and Slit-independent mechanisms
    Linda Parsons
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3010, Australia
    Dev Biol 264:363-75. 2003
    ..We have investigated the roles of the robo family members, robo, robo2, and robo3, in the guidance of sensory axons in the Drosophila embryo...
  31. pmc Interdependence of macrophage migration and ventral nerve cord development in Drosophila embryos
    Iwan R Evans
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
    Development 137:1625-33. 2010
    ....
  32. pmc Cellular components and signals required for the cardiac outflow tract assembly in Drosophila
    Monika Zmojdzian
    Unite Mixte de Recherche, Centre National de la Recherche Scientifique 6247 GreD, Clermont Ferrand University, Institut National de la Santé et de la Recherche Médicale Clermont Ferrand, Clermont Ferrand, France
    Proc Natl Acad Sci U S A 105:2475-80. 2008
    ..Our observations suggest that the similarities between Drosophila and vertebrate cardiogenesis extend beyond the early developmental events...
  33. pmc Branch architecture of the fly larval abdominal serotonergic neurons
    John Chen
    Department of Biology, University of Virginia, Gilmer Hall 071 Box 400328, Charlottesville, VA 22903, USA
    Dev Biol 320:30-8. 2008
    ..Furthermore, the basic branching pattern of serotonergic neurons within the neuropil remains unchanged despite alterations of initial axonal trajectories...
  34. pmc Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons
    Yimiao Ou
    Centre for Research in Neuroscience, McGill University, Cedar Ave, Montreal, QC, H3G 1A4, Canada
    Neural Dev 3:16. 2008
    ..To address these issues, we have carried out two comparable gain-of-function screens for genes that influence dendrite morphologies in peripheral dendritic arborisation (da) neurons and central RP2 motor neurons...
  35. pmc Functional diversity of Robo receptor immunoglobulin domains promotes distinct axon guidance decisions
    Timothy A Evans
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Curr Biol 20:567-72. 2010
    ..Ig superfamily receptors respond to their common Slit ligand to regulate axon guidance at the midline: Robo and Robo2 mediate midline repulsion, Robo2 and Robo3 control longitudinal pathway selection, and Robo2 can promote midline ..
  36. doi Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors
    Bettina Spitzweck
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 140:409-20. 2010
    ..the Drosophila CNS is constructed in part under the control of three Robo family axon guidance receptors: Robo1, Robo2 and Robo3. Each of these receptors is responsible for a distinct set of guidance decisions...
  37. doi Intra-axonal patterning: intrinsic compartmentalization of the axonal membrane in Drosophila neurons
    Takeo Katsuki
    Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan
    Neuron 64:188-99. 2009
    ..We propose that this intra-axonal compartmentalization is an intrinsic property of Drosophila neurons that provides a basis for the structural and functional development of the nervous system...
  38. pmc Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis
    Marta Zlatic
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 7:e1000135. 2009
    ..Together our findings support the idea that axons are delivered to particular regions of the neuropile by their responses to systems of positional cues in each dimension...
  39. pmc Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2
    Hiroko Sano
    Department of Cell Biology, Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Howard Hughes Medical Institute, New York University Medical Center, New York, NY 10016
    J Cell Biol 171:675-83. 2005
    ..Our results suggest that expression of wun/wun-2 repellents along the migratory paths provides faithful control over the sorting of PGCs into two gonads and eliminates PGCs left in the middle of the embryo...
  40. ncbi A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding
    Zachary Wills
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 36:611-22. 2002
    ..These studies identify Capulet as part of an emerging pathway linking guidance signals to regulation of cytoskeletal dynamics and suggest that the Abl pathway mediates signals downstream of multiple Roundabout receptors...
  41. ncbi Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea
    Camilla Englund
    Umea Centre for Molecular Pathogenesis, Umea University, Sweden
    Development 129:4941-51. 2002
    ..Robo and Robo2 are expressed in different branches, and are both necessary for the correct orientation of branch outgrowth...
  42. ncbi Axon guidance: the cytoplasmic tail
    Bharatkumar N Patel
    Program in Neuroscience, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Cell Biol 14:221-9. 2002
    ..Recent studies demonstrate a critical role for the cytoplasmic tails of guidance receptors in signalling and also reveal the potential for a great deal of crosstalk between the various receptor-signalling pathways...
  43. ncbi Spatial regulation of segment polarity gene expression in the anterior terminal region of the Drosophila blastoderm embryo
    J Mohler
    Department of Biological Sciences, Barnard College, New York, NY 10027, USA
    Mech Dev 50:151-61. 1995
    ..None of these five known gap genes are required for the activation of the labral segment domains of hh and wg, which are presumably either activated directly by maternal pathways or by an unidentified gap gene...
  44. ncbi The function of leak and kuzbanian during growth cone and cell migration
    K Schimmelpfeng
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, 48149, Munster, Germany
    Mech Dev 106:25-36. 2001
    ..Our analyses support a model in which Kuzbanian mediates the proteolytic activation of the Slit/Roundabout receptor complex...
  45. ncbi A new code for axons
    G Tear
    Nature 409:472-3. 2001
  46. ncbi Neurobiology. The come-hither, don't-touch-me proteins
    G Vogel
    Science 290:2243-4. 2000
    ..December issue of Neuron, two independent teams report that flies have two proteins very similar to Robo, called Robo2 and Robo3...
  47. ncbi New Roundabouts send axons into the Fas lane
    J Rusch
    Department of Cell Biology and, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 28:637-40. 2000
  48. ncbi Slit proteins: key regulators of axon guidance, axonal branching, and cell migration
    K Brose
    Departments of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 0452, USA
    Curr Opin Neurobiol 10:95-102. 2000
    ....
  49. ncbi Axon guidance: starting and stopping with slit
    S Guthrie
    Department of Developmental Neurobiology, Hodgkin Building King s College, Guy s Campus, London, SE1 9RT, UK
    Curr Biol 9:R432-5. 1999
    ..Now, the Slit protein has been discovered to have striking positive and negative effects on axon growth and guidance...
  50. ncbi The middle and the end: slit brings guidance and branching together in axon pathway selection
    D Van Vactor
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 22:649-52. 1999
  51. ncbi Movement through Slits: cellular migration via the Slit family
    Michael Piper
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
    Bioessays 25:32-8. 2003
    ..This review focuses on the non-neuronal activities of Slit proteins, highlighting a common role for the Slit family in cellular migration...
  52. ncbi Signaling systems, guided cell migration, and organogenesis: insights from genetic studies in Drosophila
    Carlos Ribeiro
    Biozentrum der Universitat Basel, Department of Cell Biology, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Biol 260:1-8. 2003
    ....
  53. ncbi Heparan sulfate proteoglycan syndecan promotes axonal and myotube guidance by slit/robo signaling
    Patrick Steigemann
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Goettingen, Germany
    Curr Biol 14:225-30. 2004
    ..The results suggest that Syndecan is a necessary component of Slit/Robo signaling and is required in the Slit target cells...
  54. ncbi Drosophila central brain formation requires Robo proteins
    Emmanuelle Nicolas
    Institut Jacques Monod, Tour 42 43, 5éme étage 2 place jussieu, 75005 Paris, France
    Dev Genes Evol 215:530-6. 2005
    ..Mutations of robo2 and robo3 confer a series of strong MB and CX defects...
  55. ncbi NETRIN and SLIT guide salivary gland migration
    Tereza Kolesnikov
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Dev Biol 284:102-11. 2005
    ..We propose that analogous to axon guidance, a balance between chemo-attractants and chemo-repellents is required for the proper migratory path of the developing salivary glands...
  56. pmc Compartmentalization of visual centers in the Drosophila brain requires Slit and Robo proteins
    Timothy D Tayler
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue 68 230B, Cambridge, MA 02139, USA
    Development 131:5935-45. 2004
    ..We find that loss of Slit or simultaneous knockdown of Robo, Robo2 and Robo3 causes distal cell neurons to invade the lamina, resulting in cell mixing across the lamina/lobula ..
  57. pmc Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons
    Annika Lundström
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 106 96 Stockholm, Sweden
    Genes Dev 18:2161-71. 2004
    ..These results together with genetic interaction experiments with robo, vilse, and rac mutants suggest a mechanism whereby Robo repulsion is mediated by the localized inactivation of Rac through Vilse...
  58. pmc Roundabout 2 regulates migration of sensory neurons by signaling in trans
    Rachel Kraut
    Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 14:1319-29. 2004
    ..The development of Drosophila embryonic sense organs provides a neuronal migration paradigm where the in vivo roles of Slit and Robo can be assayed using genetics...
  59. ncbi The Drosophila Wnt5 protein mediates selective axon fasciculation in the embryonic central nervous system
    Lee G Fradkin
    Department of Molecular and Cell Biology, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Dev Biol 272:362-75. 2004
    ..Finally, we demonstrate that transcriptional repression of wnt5 in AC neurons by the recently described Wnt5 receptor, Derailed, contributes to this largely posterior commissural localization of Wnt5 protein...
  60. ncbi The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance
    Haeryun Lee
    Department of Cell Biology, Program in Neuroscience, Dana Farber Cancer Institute Harvard Cancer Center and Harvard Center of Neurodegeneration and Repair, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Neuron 42:913-26. 2004
    ..These and other data suggest a model where Abl acts as a central signaling node to coordinate actin and microtubule dynamics downstream of guidance receptors...
  61. ncbi Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila
    Virginie Orgogozo
    Ecole Normale Superieure, UMR 8542, 46 rue d Ulm, 75005 Paris, France
    Mech Dev 121:427-36. 2004
    ..Our observations indicate that in slit mutant embryos, as well as in robo, robo2 double mutants, sensory precursor cells of the left and right vmd1a neurons aberrantly cluster at the midline and ..
  62. ncbi Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling
    Dhanisha Jhaveri
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India
    Development 131:1903-12. 2004
    ..Our data suggests that guidance of axons across brain hemispheres is mediated by Slit-dependent Robo2 signaling...
  63. ncbi Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance
    Karl G Johnson
    Harvard Medical School, Department of Cell Biology, Program in Neuroscience, 240 Longwood Avenue, Boston, MA 02115, USA
    Curr Biol 14:499-504. 2004
    ....
  64. ncbi robo2 and robo3 interact with eagle to regulate serotonergic neuron differentiation
    Jessica A Couch
    Department of Biology, 071 Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Development 131:997-1006. 2004
    ..Additionally, we show that the axon guidance molecules roundabout2 and roundabout3 (robo2/3) are necessary for serotonergic neuron differentiation and function independently of ..
  65. ncbi Neuronal guidance. A genetic perspective
    G Tear
    Department of Biochemistry, Imperial College, London, UK
    Trends Genet 15:113-8. 1999
    ..Here I highlight the part genetic screens and analyses have played in revealing some of the key players in neuronal guidance...

Research Grants1

  1. Genes Essential To Motor Axon Guidance in Drosophila
    David Van Vactor; Fiscal Year: 2009
    ..We will use a combination of genetics, cell biology and biochemistry to determine each protein's function in axon guidance and to dissect the signaling mechanisms that regulate the key effector activities. ..