Kr

Summary

Gene Symbol: Kr
Description: Kruppel
Alias: CG3340, Dm-Kr, Dmel\CG3340, CG3340 gene product from transcript CG3340-RB, CG3340-PA, CG3340-PB, Kr-PA, Kr-PB, irregular facets, krpple, krueppel, kruppel, kuppel, lruppel
Species: fruit fly

Top Publications

  1. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
  2. pmc Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors
    - Manu
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Comput Biol 5:e1000303. 2009
  3. pmc Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila species
    Robert K Bradley
    Department of Mathematics, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 8:e1000343. 2010
  4. pmc Deciphering a transcriptional regulatory code: modeling short-range repression in the Drosophila embryo
    Walid D Fakhouri
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
    Mol Syst Biol 6:341. 2010
  5. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
  6. ncbi Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio
    D K Pritchard
    Department of Genetics, University of Washington, Seattle, Washington, USA
    Genes Dev 10:1131-42. 1996
  7. ncbi Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes
    T Gutjahr
    Institute of Molecular Biology II, University of Zurich, Switzerland
    Development 117:609-23. 1993
  8. pmc dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo
    Y Nibu
    Department of Molecular and Cellular Biology, Division of Genetics, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    EMBO J 17:7009-20. 1998
  9. ncbi Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila
    D Stanojevic
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Nature 341:331-5. 1989
  10. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006

Research Grants

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  2. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
  3. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
  4. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  5. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
  6. SUMO conjugation in cell biology and Development
    Albert J Courey; Fiscal Year: 2010
  7. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
  8. Compartmentalized Exosome Structure and Function
    Erik D Andrulis; Fiscal Year: 2010
  9. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
  10. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006

Detail Information

Publications173 found, 100 shown here

  1. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
    ....
  2. pmc Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors
    - Manu
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Comput Biol 5:e1000303. 2009
    ..The result confirms the idea that attractors are important for developmental stability and shows a richer variety of dynamical attractors in developmental systems than has been previously recognized...
  3. pmc Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila species
    Robert K Bradley
    Department of Mathematics, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 8:e1000343. 2010
    ....
  4. pmc Deciphering a transcriptional regulatory code: modeling short-range repression in the Drosophila embryo
    Walid D Fakhouri
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
    Mol Syst Biol 6:341. 2010
    ..unexpected features of these proteins' activity that allow accurate predictions of regulation by the Giant, Knirps, Krüppel, and Snail repressors, including modeling of an endogenous enhancer...
  5. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
    ..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
  6. ncbi Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio
    D K Pritchard
    Department of Genetics, University of Washington, Seattle, Washington, USA
    Genes Dev 10:1131-42. 1996
    ..embryos shifts the activation of ftz transcription either forward or backward during development but does not effect Krüppel (Kr) activation...
  7. ncbi Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes
    T Gutjahr
    Institute of Molecular Biology II, University of Zurich, Switzerland
    Development 117:609-23. 1993
    ..mutants even-skipped, runt and hairy, and in all gap mutants suggests that the products of the gap genes hunchback, Krüppel, knirps and giant activate paired expression in stripes...
  8. pmc dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo
    Y Nibu
    Department of Molecular and Cellular Biology, Division of Genetics, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    EMBO J 17:7009-20. 1998
    ..Here we present evidence that three different repressors, Knirps, Krüppel and Snail, recruit a different co-repressor, dCtBP...
  9. ncbi Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila
    D Stanojevic
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Nature 341:331-5. 1989
    ..The two best characterized gap genes, hunchback (hb) and Krüppel (Kr), contain homologies with the zinc-finger DNA-binding motif, although their mode of action in the early ..
  10. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006
    ..To model and thoroughly understand animal transcription networks, it is essential to derive accurate spatial and temporal descriptions of developing gene expression patterns with cellular resolution...
  11. doi A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm
    Charless C Fowlkes
    Berkeley Drosophila Transcription Network Project, University of California, Irvine, CA 92697, USA
    Cell 133:364-74. 2008
    ..We present a VirtualEmbryo containing data for 95 genes at six time cohorts. We show that known gene-regulatory interactions can be automatically recovered from this data set and predict hundreds of new interactions...
  12. pmc A biophysical model for analysis of transcription factor interaction and binding site arrangement from genome-wide binding data
    Xin He
    Department of Computer Science, University of Illinois at Urbana Champaign, Champaign, Illinois, United States of America
    PLoS ONE 4:e8155. 2009
    ..How transcription factors (TFs) interact with cis-regulatory sequences and interact with each other is a fundamental, but not well understood, aspect of gene regulation...
  13. ncbi Dose-dependent regulation of pair-rule stripes by gap proteins and the initiation of segment polarity
    R Warrior
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    Development 110:759-67. 1990
    ..that autoregulation also plays an important role in this process since there is a reduction in the levels of Kruppel (Kr) RNA and protein in a Kr null mutant...
  14. ncbi Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues
    T Goto
    Department of Biochemistry, Harvard University, Cambridge, Massachusetts 02138
    Cell 57:413-22. 1989
    ..As a consequence of this two-step regulatory program, eve functions both in the establishment of the periodic pattern of gene expression and in the subsequent specification of parasegmental boundaries...
  15. pmc cis-acting control elements for Krüppel expression in the Drosophila embryo
    M Hoch
    Institut für Genetik und Mikrobiologie der Universität München, FRG
    EMBO J 9:2587-95. 1990
    b>Krüppel (Kr), a gap gene of Drosophila, shows complex spatial patterns of expression during the different stages of embryogenesis...
  16. ncbi The role of the NK-homeobox gene slouch (S59) in somatic muscle patterning
    S Knirr
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 126:4525-35. 1999
    ..Together, these findings provide new insights into the regulatory interactions that establish the somatic muscle pattern...
  17. pmc FlyEx, the quantitative atlas on segmentation gene expression at cellular resolution
    Andrei Pisarev
    Department of Computational Biology, St Petersburg State Polytechnical University, St Petersburg 195251, Russia
    Nucleic Acids Res 37:D560-6. 2009
    ..5 h of development. FlyEx supports the data downloads and construction of personal reference datasets, that makes it possible to more effectively use and analyze data...
  18. ncbi Regulation of Krüppel expression in the anlage of the Malpighian tubules in the Drosophila embryo
    U Gaul
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, F R G
    Mech Dev 33:57-67. 1990
    ..Among other tissues, the central gap gene Krüppel is expressed and required in the anlage of the Malpighian tubules at the posterior terminus of the embryo...
  19. pmc Pre-steady-state decoding of the Bicoid morphogen gradient
    Sven Bergmann
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS Biol 5:e46. 2007
    ..This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage...
  20. ncbi Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells
    P Zuo
    Department of Biological Sciences, Columbia University, New York, New York 10027
    Genes Dev 5:254-64. 1991
    We have studied the ability of the Drosophila gap proteins Krüppel and hunchback to function as transcriptional regulators in cultured cells...
  21. ncbi Evidence for an epigenetic mechanism by which Hsp90 acts as a capacitor for morphological evolution
    Vincent Sollars
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Genet 33:70-4. 2003
    ..Using a sensitized isogenic D. melanogaster strain, iso-Kr(If-1), we confirm this finding and present evidence supporting an epigenetic mechanism for Hsp90's capacitor ..
  22. pmc Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm
    Xiao Yong Li
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Biol 6:e27. 2008
    ....
  23. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  24. ncbi Segregation of myogenic lineages in Drosophila requires numb
    M Ruiz Gomez
    Department of Zoology, Cambridge, UK
    Development 124:4857-66. 1997
    ..Numb acts to block Notch-mediated repression of genes expressed in muscle progenitor cells. Thus asymmetric cell divisions are essential determinants of muscle fates during myogenesis in Drosophila..
  25. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II: dynamics
    Soile V E Keränen
    Berkeley Drosophila Transcription Network Project, Genomics Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA
    Genome Biol 7:R124. 2006
    ..To accurately describe gene expression and computationally model animal transcriptional networks, it is essential to determine the changing locations of cells in developing embryos...
  26. pmc Parameter estimation and determinability analysis applied to Drosophila gap gene circuits
    Maksat Ashyraliyev
    CWI, Kruislaan 413, 1098 SJ Amsterdam, The Netherlands
    BMC Syst Biol 2:83. 2008
    ..Once the parameters are found by means of optimization, it is important to assess the quality of the parameter estimates, especially if parameter values are used to draw biological conclusions from the model...
  27. pmc Gene circuit analysis of the terminal gap gene huckebein
    Maksat Ashyraliyev
    Center for Mathematics and Computer Science, Centrum Wiskunde and Informatica, Amsterdam, The Netherlands
    PLoS Comput Biol 5:e1000548. 2009
    ..This is an important step towards a better, quantitative understanding of the developmental and evolutionary dynamics of the gap gene network...
  28. ncbi Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead
    E A Wimmer
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 53:235-45. 1995
    ..Finally, the terminal system takes part in the regulation of btd head stripe expression by enhancing activation at low levels of activity and repression at high levels of activity...
  29. ncbi Specific muscle identities are regulated by Krüppel during Drosophila embryogenesis
    M Ruiz-Gomez
    Department of Zoology, University of Cambridge, UK
    Development 124:3407-14. 1997
    ..We find that the segmentation gene Krüppel is expressed in a subset of founders and muscles, regulates specific patterns of gene expression in these ..
  30. ncbi Drosophila dumbfounded: a myoblast attractant essential for fusion
    M Ruiz-Gomez
    Department of Zoology, University of Cambridge, United Kingdom
    Cell 102:189-98. 2000
    ..duf encodes a member of the immunoglobulin superfamily of proteins that is an attractant for fusion-competent myoblasts. It is expressed by founder cells and serves to attract clusters of myoblasts from which myotubes form by fusion...
  31. pmc Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development
    G S Wilkie
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, United Kingdom
    RNA 7:1781-92. 2001
    ..We conclude that NXF-1 is an essential ubiquitous export factor for all mRNAs throughout development in higher eukaryotes...
  32. ncbi Quantitative epigenetics
    Suzanne L Rutherford
    Nat Genet 33:6-8. 2003
  33. ncbi Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance
    Todd A Sangster
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Bioessays 26:348-62. 2004
    ..A true understanding of evolutionary processes will require an integration of current evolutionary paradigms with the many new insights accruing in protein science...
  34. pmc Krüppel homolog 1 (Kr-h1) mediates juvenile hormone action during metamorphosis of Drosophila melanogaster
    Chieka Minakuchi
    Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
    Mech Dev 125:91-105. 2008
    ..In a microarray analysis of JH-induced gene expression in abdominal integument, we found that Krüppel homolog 1 (Kr-h1) was up-regulated during most of adult development...
  35. pmc Inferring Drosophila gap gene regulatory network: a parameter sensitivity and perturbation analysis
    Yves Fomekong-Nanfack
    Section Computational Science, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands
    BMC Syst Biol 3:94. 2009
    ..Consequently, it is important to address the quality of the circuits in terms of model robustness...
  36. pmc Evolutionary mirages: selection on binding site composition creates the illusion of conserved grammars in Drosophila enhancers
    Richard W Lusk
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 6:e1000829. 2010
    ..Overlapping sites, such as those frequently observed for the activator Bicoid and repressor Krüppel, had significantly longer evolutionary half-lives than isolated sites for the same factors...
  37. ncbi Spatial control of the gap gene knirps in the Drosophila embryo by posterior morphogen system
    M J Pankratz
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Science 255:986-9. 1992
    ..These results provide direct molecular evidence that the posterior morphogen system interacts in a fundamentally different manner than do hunchback and bicoid, which are responsible for anterior pattern formation...
  38. ncbi Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo
    G Bronner
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, F R G
    Mech Dev 35:205-11. 1991
    ..This, in turn, suggests that the terminal gap gene activities prevent metamerization by repression of central gap genes, thereby distinguishing the segmented trunk from the nonsegmented tail region of the embryo...
  39. ncbi Spatial regulation of the gap gene giant during Drosophila development
    R Kraut
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    Development 111:601-9. 1991
    ..These results suggest that gt is a bona fide gap gene, which acts with hb, Krüppel and kni to initiate striped patterns of gene expression in the early embryo.
  40. ncbi Dual role of the Drosophila pattern gene tailless in embryonic termini
    E Steingrimsson
    Department of Biology, University of California, Los Angeles 90024
    Science 254:418-21. 1991
    ..Ectopic expression of the tll gene also represses segmentation by repressing the gap genes Krüppel and knirps and probably also pair rule genes.
  41. ncbi A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo
    M Hulskamp
    Institut für Genetik and Mikrobiologie, Universitat Munchen, FRG
    Nature 346:577-80. 1990
    ..Differential concentrations of hb protein determine the anterior and posterior borders of expression of the gap gene Krüppel (Kr) and the anterior border of the gap gene knirps (kni), thus defining three positional values...
  42. pmc A novel spatial transcription pattern associated with the segmentation gene, giant, of Drosophila
    J Mohler
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    EMBO J 8:1539-48. 1989
    ..The effect of mutations in three other gap loci, Kr, kni and hb, were also analyzed.
  43. ncbi The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters
    J Treisman
    Howard Hughes Medical Institute, Rockefeller University, New York 10021
    Nature 341:335-7. 1989
    ..Here we report that the Krüppel (Kr) gene product (Kr) binds to the sequence AAGGGGTTAA, whereas the hunchback (hb) gene product (Hb) ..
  44. ncbi Pole region-dependent repression of the Drosophila gap gene Krüppel by maternal gene products
    U Gaul
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Federal Republic of Germany
    Cell 51:549-55. 1987
    We examined the protein domain of the gap gene Krüppel (Kr) in mutants that affect the establishment of different regions of the segment pattern along the longitudinal axis of the Drosophila embryo...
  45. ncbi Expression, function, and regulation of the hairy segmentation protein in the Drosophila embryo
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Genes Dev 2:883-90. 1988
    ..The pattern of hairy expression in gap gene mutants that affect ftz expression indicates that the gap genes largely act indirectly upon ftz through their effects on hairy...
  46. ncbi Activation of posterior gap gene expression in the Drosophila blastoderm
    R Rivera-Pomar
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Nature 376:253-6. 1995
    ..transcription factor hunchback to activate the anterior zygotic patterning genes, including the central gap gene Krüppel (Kr)...
  47. ncbi Transcriptional repression in development
    S Gray
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    Curr Opin Cell Biol 8:358-64. 1996
    ..The former permit enhancer autonomy in modular promoters, whereas the latter function in a dominant fashion to silence multiple enhancers...
  48. ncbi From gradients to stripes in Drosophila embryogenesis: filling in the gaps
    R Rivera-Pomar
    Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Trends Genet 12:478-83. 1996
    ..Recent progress has begun to reveal the mechanisms by which coherent positional information of maternal origin becomes transferred into serially repeated zygotic gene expression domains reflecting the metameric body plan of the larva...
  49. ncbi Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins
    D Kosman
    Brookdale Center for Molecular Biology, Box 1126, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Genes Evol 208:290-4. 1998
    ..Antigenicity of the purified recombinant proteins may be increased by precipitation in double-distilled water. The results of using the serums obtained for fluorescent staining of Drosophila embryos are shown...
  50. ncbi Segmentation: painting stripes from flies to vertebrates
    L Pick
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Dev Genet 23:1-10. 1998
  51. ncbi The Drosophila semushi mutation blocks nuclear import of bicoid during embryogenesis
    J L Epps
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    Curr Biol 8:1277-80. 1998
    ..Consequently, semi embryos have multiple defects in anterior segmentation. This study demonstrates that an E2 enzyme is required for nuclear transport during Drosophila embryogenesis...
  52. ncbi Transcriptional coregulators in development
    M Mannervik
    Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Science 284:606-9. 1999
    ..Recent studies suggest that a growing set of coactivators and corepressors mediate communication between diverse upstream regulatory proteins and the core RNA polymerase II transcription complex...
  53. pmc Structure and regulation of the salivary gland secretion protein gene Sgs-1 of Drosophila melanogaster
    G E Roth
    Institut fur Genetik, Freie Universitat Berlin, 14195 Berlin, Germany
    Genetics 153:753-62. 1999
    ..This has implications for the model of how Sgs transcripts accumulate in late third instar larvae...
  54. ncbi Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene
    M J Shimell
    Department of Genetics, University of Minnesota, Minneapolis, Minnesota, 55455, USA
    Dev Biol 218:38-52. 2000
    ..7)] from the iab-2 regulatory region shows that in contrast to Ubx enhancer elements, both HB and Krüppel (KR) are required to set the ABD-A anterior boundary in parasegment 7...
  55. ncbi A logical analysis of the Drosophila gap-gene system
    L Sanchez
    Centro de Investigaciones Biologicas, Velazquez 144, Madrid, 28006, Spain
    J Theor Biol 211:115-41. 2001
    ..with each of the key regulatory factors (the three maternal Bcd, Hb and Cad products, and the four gap Gt, Hb, Kr and Kni products); (2) the most crucial interactions and regulatory circuits of the earliest stages of the ..
  56. ncbi Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes
    Sheng Zhang
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA
    Cell 108:45-56. 2002
    ..We propose that Atrophin proteins function as versatile transcriptional corepressors and discuss a model that deregulation of transcription may contribute to the pathogenesis of neurodegeneration...
  57. pmc Extraction of functional binding sites from unique regulatory regions: the Drosophila early developmental enhancers
    Dmitri A Papatsenko
    Department of Biology, New York University, New York, NY 10003 6688, USA
    Genome Res 12:470-81. 2002
    ..We also discuss the definition of true binding sites and the possible biological principles that govern patterning of regulatory regions and the distribution of transcriptional signals...
  58. ncbi Drosophila Yurt is a new protein-4.1-like protein required for epithelial morphogenesis
    Kevin B Hoover
    Developmental Biology Center, University of California, Irvine, CA 92697, USA
    Dev Genes Evol 212:230-8. 2002
    ..A mammalian homolog of Yurt is up-regulated in metastatic melanoma cells. These novel cytoskeletal proteins appear to play important roles in epithelial cell movements and in the morphogenetic tissue changes that depend on them...
  59. ncbi A self-organizing system of repressor gradients establishes segmental complexity in Drosophila
    Dorothy E Clyde
    Biology Department, New York University, New York, New York 10003, USA
    Nature 426:849-53. 2003
    ..They also support the utility of computational analyses for defining and deciphering regulatory information contained in genomic DNA...
  60. ncbi Dynamic control of positional information in the early Drosophila embryo
    Johannes Jaeger
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York 11794 3600, USA
    Nature 430:368-71. 2004
    ....
  61. pmc Dynamical analysis of regulatory interactions in the gap gene system of Drosophila melanogaster
    Johannes Jaeger
    Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794 3600, USA
    Genetics 167:1721-37. 2004
    ..Our models predict activation of Kr by Cad and clarify several other regulatory interactions...
  62. pmc Engineering gene networks to emulate Drosophila embryonic pattern formation
    Mark Isalan
    European Molecular Biology Laboratory, Structures and Biocomputing, Heidelberg, Germany
    PLoS Biol 3:e64. 2005
    ..We anticipate that the system described here will be generally applicable to the study of any biological network with a spatial component...
  63. pmc The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila
    Amanda Ochoa-Espinosa
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 102:4960-5. 2005
    ..Also, many Bcd-dependent CRMs contain clusters of sites for the gap protein Kruppel, which may limit the posterior extent of activation by the Bcd gradient...
  64. pmc Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila
    Danielle Lebrecht
    Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Proc Natl Acad Sci U S A 102:13176-81. 2005
    ..The mutants did not faithfully stimulate transcription of downstream target genes such as hunchback (hb), giant, and Krüppel...
  65. pmc EVOPRINTER, a multigenomic comparative tool for rapid identification of functionally important DNA
    Ward F Odenwald
    Neural Cell Fate Determinants Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:14700-5. 2005
    ..Also, evoprinter allows one to assess the degree of evolutionary divergence between orthologous DNAs by highlighting differences between a selected species and the other test species...
  66. ncbi Morphogens: precise outputs from a variable gradient
    Gozde Yucel
    Department of Biology, New York University, New York, NY 10003, USA
    Curr Biol 16:R29-31. 2006
    ..Several recent papers examine the patterning activities of Drosophila Bicoid, the first known molecular morphogen and reach different conclusions about the patterning power of a single morphogen gradient...
  67. pmc Evolutionary conservation pattern of zinc-finger domains of Drosophila segmentation genes
    R J Sommer
    Zoologisches Institut, Universitat Munchen, Federal Republic of Germany
    Proc Natl Acad Sci U S A 89:10782-6. 1992
    ..Using PCR, we were able to obtain apparently orthologous fragments of hunchback (hb), Krüppel (Kr), and snail (sna) from a variety of arthropods and partly also from other animal phyla...
  68. ncbi Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes
    G Riddihough
    Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK
    Genes Dev 5:840-54. 1991
    ..Our results suggest that different but overlapping subsets of gap genes regulate each stripe and that activation and repression are both important in generating the stripe pattern...
  69. ncbi Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps
    U Nauber
    Institut fur Genetik und Mikrobiologie, LMU Munchen, FRG
    Nature 336:489-92. 1988
    ..Here we report the molecular characterization of the kni gene that codes for a member of the steroid/thyroid receptor superfamily of proteins which in vertebrates act as ligand-dependent DNA-binding transcription regulators...
  70. ncbi Disruption of a putative Cys-zinc interaction eliminates the biological activity of the Krüppel finger protein
    N Redemann
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, FRG
    Nature 332:90-2. 1988
    ..One of these, Krüppel (Kr), acts at the first level of the segmentation gene hierarchy, and its protein product may bind to DNA...
  71. ncbi Positioning adjacent pair-rule stripes in the posterior Drosophila embryo
    J A Langeland
    Howard Hughes Medical Institute, R M Bock Laboratories, University of Wisconsin, Madison 53706, USA
    Development 120:2945-55. 1994
    ..Interestingly, Krüppel (Kr) limits the anterior expression limits of both stripes and is the only gap gene to do so, indicating that ..
  72. ncbi Mechanism of eve stripe formation
    J Reinitz
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 49:133-58. 1995
    ..Third is the use of least squares fits to gene expression data to measure phenomenological parameters occurring in the gene circuit...
  73. ncbi The eve stripe 2 enhancer employs multiple modes of transcriptional synergy
    D N Arnosti
    Department of Biology, UCSD, La Jolla 92093 0347, USA
    Development 122:205-14. 1996
    ..stripe in the anterior half of the embryo, bcd also coordinates the expression of two repressors, giant (gt) and Kruppel (Kr), which define the anterior and posterior borders of the stripe, respectively...
  74. ncbi Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo
    S Small
    Department of Biology, New York University, New York 10003, USA
    Dev Biol 175:314-24. 1996
    ..These findings suggest a general model for the regulation of segmentation stripes, whereby enhancers integrate positional information provided by broadly distributed activators and spatially restricted repressors...
  75. ncbi Gene regulation in the Drosophila embryo
    F Sauer
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA
    Philos Trans R Soc Lond B Biol Sci 351:579-87. 1996
    ....
  76. ncbi Orthodenticle regulation during embryonic head development in Drosophila
    Q Gao
    University of Pennsylvania School of Medicine, Department of Neuroscience, Philadelphia, PA 19104, USA
    Mech Dev 56:3-15. 1996
    ..Finally, we identify a novel pathway mediated by the gap gene huckebein through which three maternal systems cooperate to repress otd expression at the anterior terminus of the embryo...
  77. ncbi Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps
    D Kosman
    Department of Biology, New York University, NY 10003, USA
    Development 124:1343-54. 1997
    ..Evidence is presented that the level and timing of expression, as well as protein diffusion, are important for determining the specific responses of target genes...
  78. ncbi Stripe forming architecture of the gap gene system
    J Reinitz
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, NY 10029, USA
    Dev Genet 23:11-27. 1998
    ..It is argued that the constraints on gap gene architecture identified here are a consequence of selective pressures that minimize the number of gap genes required to determine segments in long-germ band insects...
  79. ncbi Antisocial, an intracellular adaptor protein, is required for myoblast fusion in Drosophila
    E H Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Dev Cell 1:705-15. 2001
    ..These findings suggest that ANTS functions as an intracellular adaptor protein that relays signals from Dumbfounded to the cytoskeleton during myoblast fusion...
  80. ncbi Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development
    Alfrun Erkner
    Laboratoire de Genetique et Physiologie du Developpement, UMR 9943 C N R S Université, I B D M CNRS INSERM Université de la Méditerranée, Campus de Luminy Case 907, F 13288 Marseille, Cedex 09, France
    Development 129:1119-29. 2002
    ..Grunge has other regulatory functions in the leg, including the patterning of ventral parts along the entire proximodistal axis and the proper spacing of bristles in all regions...
  81. ncbi Turnover of binding sites for transcription factors involved in early Drosophila development
    Javier Costas
    Instituto de Biologia Molecular e Celular IBMC, Universidade do Porto, Rua do Campo Alegre 823, 4150 180, Porto, Portugal
    Gene 310:215-20. 2003
    ..Finally, we detected a significant decrease in mean PWM scores for the D. virilis binding sites in the case of Hunchback. Possible explanations for this fact are discussed...
  82. ncbi Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6
    Elizabeth H Chen
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 114:751-62. 2003
    ..In muscle cells, this fusigenic mechanism is coupled to fusion receptors; in other fusion-competent cell types it may be triggered by different upstream signals...
  83. ncbi Groucho-dependent repression by sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo
    Luiz P Andrioli
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Dev Biol 276:541-51. 2004
    ..The Slp1 protein contains a protein motif (EH1) which mediates binding to the transcriptional corepressor Groucho (Gro). We show that this domain is required for Slp1-mediated repression in vivo...
  84. ncbi Arthropod segmentation: beyond the Drosophila paradigm
    Andrew D Peel
    University Museum of Zoology, Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK
    Nat Rev Genet 6:905-16. 2005
    ..A model is emerging, although slowly, for the way that arthropod segmentation mechanisms have evolved...
  85. pmc Dual regulation by the Hunchback gradient in the Drosophila embryo
    Dmitri Papatsenko
    Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, and Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:2901-6. 2008
    ..Models based on dual regulation suggest that the Hb gradient can be sufficient for establishing the initial Kruppel (Kr) expression pattern in central regions of the precellular embryo...
  86. pmc Evolution of regulatory sequences in 12 Drosophila species
    Jaebum Kim
    Department of Computer Science, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
    PLoS Genet 5:e1000330. 2009
    ....
  87. pmc Relationship between gene co-expression and sharing of transcription factor binding sites in Drosophila melanogaster
    Antonio Marco
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Arizona State University, Tempe, AZ 85287 5301, USA
    Bioinformatics 25:2473-7. 2009
    ..We have also examined the reverse relationship between the expression correlation and the extent of TFBS sharing...
  88. pmc STAT is an essential activator of the zygotic genome in the early Drosophila embryo
    Amy Tsurumi
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Genet 7:e1002086. 2011
    ..We further show that STAT92E and Zelda synergistically regulate transcription. We conclude that STAT92E, in conjunction with Zelda, plays an important role in transcription of the zygotic genome at the onset of embryonic development...
  89. pmc The Drosophila gap gene network is composed of two parallel toggle switches
    Dmitri Papatsenko
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Black Family Stem Cell Institute, New York, New York, United States of America
    PLoS ONE 6:e21145. 2011
    ..The identified model solutions (parameter combinations) reproduced major dynamic features of the gap gradient system and explained gap expression in a variety of segmentation mutants...
  90. pmc Mechanisms of gap gene expression canalization in the Drosophila blastoderm
    Vitaly V Gursky
    Theoretical Department, Ioffe Physical Technical Institute of the Russian Academy of Sciences, St, Petersburg, 194021 Russia
    BMC Syst Biol 5:118. 2011
    ..The canalization of gap gene expression can be understood as arising from the actions of attractors in the gap gene dynamical system...
  91. ncbi Regulation of a segmentation stripe by overlapping activators and repressors in the Drosophila embryo
    D Stanojevic
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    Science 254:1385-7. 1991
    ..Genetic studies suggested that even-skipped (eve) stripe 2 is controlled by three gap genes, hunchback (hb), Kruppel (Kr), and giant (gt), and by the maternal morphogen bicoid (bcd)...
  92. ncbi Control of the initiation of homeotic gene expression by the gap genes giant and tailless in Drosophila
    J Reinitz
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Dev Biol 140:57-72. 1990
    ..giant also regulates the establishment of the expression patterns of Antennapedia and Abdominal-B. In particular, giant is the factor that controls the anterior limit of early Antennapedia expression...
  93. ncbi Gradients of Krüppel and knirps gene products direct pair-rule gene stripe patterning in the posterior region of the Drosophila embryo
    M J Pankratz
    Institut fur Genetik und Mikrobiologie, Munchen, Federal Republic of Germany
    Cell 61:309-17. 1990
    Abdominal segmentation of the Drosophila embryo requires the activities of the gap genes Krüppel (Kr), knirps (kni), and tailless (tll)...
  94. ncbi Spatial harmonics and pattern specification in early Drosophila development. Part I. Bifurcation sequences and gene expression
    B C Goodwin
    Department of Biology, Open University, Milton Keynes, U K
    J Theor Biol 144:303-19. 1990
    ..This model has implications for the general stability properties of evolving epigenetic systems...
  95. ncbi Zebra patterns in fly embryos: activation of stripes or repression of interstripes?
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Cell 60:9-16. 1990
    ..Different gap proteins control different subsets of stripes and interstripes. Combinations of gap proteins regulate transcription by binding to far upstream elements that contain different numbers and types of binding sites...
  96. ncbi Analysis of Krüppel protein distribution during early Drosophila development reveals posttranscriptional regulation
    U Gaul
    Cell 50:639-47. 1987
    We have examined the spatial and temporal patterns of expression of the Krüppel (Kr) protein, a gap gene product, during Drosophila embryogenesis...
  97. ncbi Krüppel, a gene whose activity is required early in the zygotic genome for normal embryonic segmentation
    E Wieschaus
    Dev Biol 104:172-86. 1984
    Embryos homozygous for Krüppel die as late embryos with an altered segmentation pattern. In strong alleles the normal thoracic and anterior abdominal segments are replaced by a partial mirror image duplication of the posterior abdomen...
  98. ncbi Identical transacting factor requirement for knirps and knirps-related Gene expression in the anterior but not in the posterior region of the Drosophila embryo
    M Rothe
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 46:169-81. 1994
    ....
  99. ncbi Developmental evolution: insights from studies of insect segmentation
    N H Patel
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210 3399
    Science 266:581-90. 1994
    ....
  100. pmc Silencers in abdominal-B, a homeotic Drosophila gene
    A Busturia
    Zoological Institute, University of Zurich, Switzerland
    EMBO J 12:1415-25. 1993
    ..of the IAB5 pattern in gap mutants provide evidence that the protein products of the gap genes hunchback, Krüppel and knirps act as repressors through IAB5...
  101. ncbi Conservation of regulatory elements controlling hairy pair-rule stripe formation
    J A Langeland
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Development 117:585-96. 1993
    ..comparative approach, coupled with the analysis of reporter gene expression in gap mutant embryos suggests that the Kr and gt proteins establish the anterior and posterior borders of h stripe 5, respectively, through spatial repression...

Research Grants14

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  2. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
    ..Based on published and preliminary data, we propose that the combined activities of 5 transcriptional regulators, Kruppel, Twist, Apterous, Caupolican, and Muscle Segment Homeobox, control the morphogenesis of the lateral muscles...
  3. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  4. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  5. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. SUMO conjugation in cell biology and Development
    Albert J Courey; Fiscal Year: 2010
    ..Consequently, the research proposed here will advance our understanding of human disease. ..
  7. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
    ..Such knowledge may point to mechanisms that cause brain cells to revert to less differentiated states in brain tumors or degenerate in neurological disorders. ..
  8. Compartmentalized Exosome Structure and Function
    Erik D Andrulis; Fiscal Year: 2010
    ..An in-depth understanding of how the exosome processes and degrades mRNAs is fundamentally important to human health, as aberrant gene expression is an etiological factor in numerous disease states. ..
  9. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  10. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  11. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
  12. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....
  14. Spatial Control of Proteolysis in Dorsoventral Polarity
    ELLEN LEMOSY; Fiscal Year: 2009
    ..abstract_text> ..