kni

Summary

Gene Symbol: kni
Description: knirps
Alias: CG4717, Dmel\CG4717, KNI, KNIRPS, Kni, NR0A1, knr, CG4717 gene product from transcript CG4717-RA, CG4717-PA, CG4717-PB, kni-PA, kni-PB, radius incompletus
Species: fruit fly

Top Publications

  1. ncbi Zebra patterns in fly embryos: activation of stripes or repression of interstripes?
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Cell 60:9-16. 1990
  2. ncbi Expression, function, and regulation of the hairy segmentation protein in the Drosophila embryo
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Genes Dev 2:883-90. 1988
  3. ncbi Morphogens, compartments, and pattern: lessons from drosophila?
    P A Lawrence
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 85:951-61. 1996
  4. ncbi Establishment of developmental precision and proportions in the early Drosophila embryo
    Bahram Houchmandzadeh
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 415:798-802. 2002
  5. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
  6. pmc Deciphering a transcriptional regulatory code: modeling short-range repression in the Drosophila embryo
    Walid D Fakhouri
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
    Mol Syst Biol 6:341. 2010
  7. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
  8. pmc dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo
    Y Nibu
    Department of Molecular and Cellular Biology, Division of Genetics, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    EMBO J 17:7009-20. 1998
  9. ncbi Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes
    G Riddihough
    Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK
    Genes Dev 5:840-54. 1991
  10. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006

Research Grants

  1. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
  2. A new site-specific recombination system in Drosophila
    Georg Halder; Fiscal Year: 2005
  3. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
  4. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
  5. SUMO conjugation in cell biology and Development
    Albert J Courey; Fiscal Year: 2010

Detail Information

Publications159 found, 100 shown here

  1. ncbi Zebra patterns in fly embryos: activation of stripes or repression of interstripes?
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Cell 60:9-16. 1990
    ..Different gap proteins control different subsets of stripes and interstripes. Combinations of gap proteins regulate transcription by binding to far upstream elements that contain different numbers and types of binding sites...
  2. ncbi Expression, function, and regulation of the hairy segmentation protein in the Drosophila embryo
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Genes Dev 2:883-90. 1988
    ..The pattern of hairy expression in gap gene mutants that affect ftz expression indicates that the gap genes largely act indirectly upon ftz through their effects on hairy...
  3. ncbi Morphogens, compartments, and pattern: lessons from drosophila?
    P A Lawrence
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 85:951-61. 1996
  4. ncbi Establishment of developmental precision and proportions in the early Drosophila embryo
    Bahram Houchmandzadeh
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 415:798-802. 2002
    ..We show that genes known to interact directly with Hb are not responsible for its spatial precision, but that the maternal gene staufen may be crucial...
  5. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
    ....
  6. pmc Deciphering a transcriptional regulatory code: modeling short-range repression in the Drosophila embryo
    Walid D Fakhouri
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
    Mol Syst Biol 6:341. 2010
    ..unexpected features of these proteins' activity that allow accurate predictions of regulation by the Giant, Knirps, Krüppel, and Snail repressors, including modeling of an endogenous enhancer...
  7. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
    ..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
  8. pmc dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo
    Y Nibu
    Department of Molecular and Cellular Biology, Division of Genetics, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    EMBO J 17:7009-20. 1998
    ..Here we present evidence that three different repressors, Knirps, Krüppel and Snail, recruit a different co-repressor, dCtBP...
  9. ncbi Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes
    G Riddihough
    Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK
    Genes Dev 5:840-54. 1991
    ..Our results suggest that different but overlapping subsets of gap genes regulate each stripe and that activation and repression are both important in generating the stripe pattern...
  10. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006
    ..To model and thoroughly understand animal transcription networks, it is essential to derive accurate spatial and temporal descriptions of developing gene expression patterns with cellular resolution...
  11. doi A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm
    Charless C Fowlkes
    Berkeley Drosophila Transcription Network Project, University of California, Irvine, CA 92697, USA
    Cell 133:364-74. 2008
    ..We present a VirtualEmbryo containing data for 95 genes at six time cohorts. We show that known gene-regulatory interactions can be automatically recovered from this data set and predict hundreds of new interactions...
  12. ncbi Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues
    T Goto
    Department of Biochemistry, Harvard University, Cambridge, Massachusetts 02138
    Cell 57:413-22. 1989
    ..As a consequence of this two-step regulatory program, eve functions both in the establishment of the periodic pattern of gene expression and in the subsequent specification of parasegmental boundaries...
  13. ncbi Identical transacting factor requirement for knirps and knirps-related Gene expression in the anterior but not in the posterior region of the Drosophila embryo
    M Rothe
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 46:169-81. 1994
    The Drosophila genes knirps (kni) and knirps-related (knrl) are located within the 77E1,2 region on the left arm of the third chromosome...
  14. ncbi Positioning adjacent pair-rule stripes in the posterior Drosophila embryo
    J A Langeland
    Howard Hughes Medical Institute, R M Bock Laboratories, University of Wisconsin, Madison 53706, USA
    Development 120:2945-55. 1994
    ..Stripe 6 is critically dependent upon knirps (kni) for activation, while stripe 5 likely requires a combination of activating proteins (gap and non-gap)...
  15. pmc Mechanism and Bicoid-dependent control of hairy stripe 7 expression in the posterior region of the Drosophila embryo
    A La Rosée
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    EMBO J 16:4403-11. 1997
    ..The results suggest that the gradients of Bicoid and Caudal combine their activities to activate segmentation genes along the entire axis of the embryo...
  16. pmc Relationship between gene co-expression and sharing of transcription factor binding sites in Drosophila melanogaster
    Antonio Marco
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Arizona State University, Tempe, AZ 85287 5301, USA
    Bioinformatics 25:2473-7. 2009
    ..We have also examined the reverse relationship between the expression correlation and the extent of TFBS sharing...
  17. ncbi hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryo
    R Lehmann
    Dev Biol 119:402-17. 1987
    ..Heterozygous mutant embryos derived from a homozygous mutant germ line develop normally, indicating that maternal gene expression is not required for normal development...
  18. ncbi Mechanism of eve stripe formation
    J Reinitz
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 49:133-58. 1995
    ..Third is the use of least squares fits to gene expression data to measure phenomenological parameters occurring in the gene circuit...
  19. pmc The tailless nuclear receptor acts as a dedicated repressor in the early Drosophila embryo
    Erica Moran
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, Josep Samitier 1 5, Barcelona 08028, Spain
    Mol Cell Biol 26:3446-54. 2006
    ..We provide evidence that knirps is one such repressor gene acting between Tailless and its indirect positive targets...
  20. pmc Characterization of the Drosophila segment determination morphome
    Svetlana Surkova
    Department of Computational Biology, Center for Advanced Studies, St Petersburg State Polytechnical University, 29 Polytehnicheskaya Street, St Petersburg, 195251, Russia
    Dev Biol 313:844-62. 2008
    ..As the first quantitatively characterized morphogenetic field, this system and its behavior constitute an extraordinarily rich set of materials for the study of canalization and embryonic regulation at the molecular level...
  21. pmc Parameter estimation and determinability analysis applied to Drosophila gap gene circuits
    Maksat Ashyraliyev
    CWI, Kruislaan 413, 1098 SJ Amsterdam, The Netherlands
    BMC Syst Biol 2:83. 2008
    ..Once the parameters are found by means of optimization, it is important to assess the quality of the parameter estimates, especially if parameter values are used to draw biological conclusions from the model...
  22. pmc Gene circuit analysis of the terminal gap gene huckebein
    Maksat Ashyraliyev
    Center for Mathematics and Computer Science, Centrum Wiskunde and Informatica, Amsterdam, The Netherlands
    PLoS Comput Biol 5:e1000548. 2009
    ..This is an important step towards a better, quantitative understanding of the developmental and evolutionary dynamics of the gap gene network...
  23. pmc Three hormone receptor-like Drosophila genes encode an identical DNA-binding finger
    M Rothe
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, FRG
    EMBO J 8:3087-94. 1989
    The putative finger domain of knirps (kni), a member of the gap class of segmentation genes, was used to isolate two sequence-related genes of Drosophila melanogaster under reduced stringency hybridization conditions...
  24. ncbi Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila
    M Frasch
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Genes Dev 1:981-95. 1987
    ....
  25. ncbi Abdominal segmentation of the Drosophila embryo requires a hormone receptor-like protein encoded by the gap gene knirps
    U Nauber
    Institut fur Genetik und Mikrobiologie, LMU Munchen, FRG
    Nature 336:489-92. 1988
    ..for organizing the posterior segment pattern is a group of at least seven maternal genes and the zygotic gap gene knirps (kni). Their mutant phenotype has adjacent segments in the abdominal region of the embryo deleted...
  26. ncbi Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio
    D K Pritchard
    Department of Genetics, University of Washington, Seattle, Washington, USA
    Genes Dev 10:1131-42. 1996
    ....
  27. pmc The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo
    D N Arnosti
    Department of Biology, UCSD, La Jolla 92093 0347, USA
    EMBO J 15:3659-66. 1996
    ..Previous studies suggest that the knirps orphan receptor (kni) may repress transcription via competition, and exclude the binding of the bicoid (bcd) ..
  28. pmc Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed
    G Jimenez
    Imperial Cancer Research Fund ICRF, London WC2A 3PX, England
    Genes Dev 11:3072-82. 1997
    ..In contrast, repressor regions from the Even-skipped, Snail, Krüppel, and Knirps transcription factors are effective in the absence of Gro...
  29. pmc dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein
    S A Keller
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1319, USA
    Mol Cell Biol 20:7247-58. 2000
    ..Repressors such as Knirps, Krüppel, and Snail mediate short-range repression and interact with the dCtBP corepressor...
  30. pmc Transcriptional control in the segmentation gene network of Drosophila
    Mark D Schroeder
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, New York, USA
    PLoS Biol 2:E271. 2004
    ..The study demonstrates that computational methods are a powerful complement to experimental approaches in the analysis of transcription networks...
  31. pmc Engineering gene networks to emulate Drosophila embryonic pattern formation
    Mark Isalan
    European Molecular Biology Laboratory, Structures and Biocomputing, Heidelberg, Germany
    PLoS Biol 3:e64. 2005
    ..We anticipate that the system described here will be generally applicable to the study of any biological network with a spatial component...
  32. ncbi Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell 22:645-55. 2006
    ..Our structural and functional analysis explains the rigid conservation of the WRPW motif, the sequence flexibility of eh1 motifs, and other aspects of repressor recognition by Gro in vivo...
  33. pmc Inferring Drosophila gap gene regulatory network: a parameter sensitivity and perturbation analysis
    Yves Fomekong-Nanfack
    Section Computational Science, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands
    BMC Syst Biol 3:94. 2009
    ..Consequently, it is important to address the quality of the circuits in terms of model robustness...
  34. pmc Thermodynamics-based models of transcriptional regulation by enhancers: the roles of synergistic activation, cooperative binding and short-range repression
    Xin He
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Comput Biol 6:. 2010
    ..Our implementation of the model, called GEMSTAT, is the first publicly available program for simultaneously modeling the regulatory activities of a given set of sequences...
  35. ncbi Competition for overlapping sites in the regulatory region of the Drosophila gene Krüppel
    M Hoch
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Federal Republic of Germany
    Science 256:94-7. 1992
    ..Two hormone receptor-like proteins, encoded by the genes knirps (kni) and tailless (tll), bind specifically to the element...
  36. ncbi Spatial control of the gap gene knirps in the Drosophila embryo by posterior morphogen system
    M J Pankratz
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Science 255:986-9. 1992
    ..The gap gene knirps, required for patterning in the posterior region of the embryo, can be activated throughout the wild-type embryo ..
  37. ncbi Control of Drosophila body pattern by the hunchback morphogen gradient
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 69:237-249. 1992
    ..of Drosophila are specified early in embryogenesis by the overlapping activities of the hunchback (hb), Krüppel, knirps, and giant gap genes...
  38. ncbi Interactions of the Drosophila gap gene giant with maternal and zygotic pattern-forming genes
    E D Eldon
    Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston 77030
    Development 111:367-78. 1991
    ..Expression is never detected in the labial or thoracic segment primordia but persists in certain head structures, including the ring gland, until the end of embryonic development...
  39. ncbi Spatial regulation of the gap gene giant during Drosophila development
    R Kraut
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    Development 111:601-9. 1991
    ..studies show that the gt patterns overlap with protein gradients specified by the gap genes hunchback (hb) and knirps (kni)...
  40. ncbi Dual role of the Drosophila pattern gene tailless in embryonic termini
    E Steingrimsson
    Department of Biology, University of California, Los Angeles 90024
    Science 254:418-21. 1991
    ..Ectopic expression of the tll gene also represses segmentation by repressing the gap genes Krüppel and knirps and probably also pair rule genes.
  41. ncbi Gradients of Krüppel and knirps gene products direct pair-rule gene stripe patterning in the posterior region of the Drosophila embryo
    M J Pankratz
    Institut fur Genetik und Mikrobiologie, Munchen, Federal Republic of Germany
    Cell 61:309-17. 1990
    Abdominal segmentation of the Drosophila embryo requires the activities of the gap genes Krüppel (Kr), knirps (kni), and tailless (tll)...
  42. pmc A novel spatial transcription pattern associated with the segmentation gene, giant, of Drosophila
    J Mohler
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    EMBO J 8:1539-48. 1989
    ..The effect of mutations in three other gap loci, Kr, kni and hb, were also analyzed.
  43. ncbi Activation of posterior gap gene expression in the Drosophila blastoderm
    R Rivera-Pomar
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Nature 376:253-6. 1995
    ..but rather prevents the repressor hunchback from acting in the posterior half so that the gap genes giant (gt) and knirps (kni) are activated by an as yet unknown transcription factor...
  44. ncbi Zygotic caudal regulation by hunchback and its role in abdominal segment formation of the Drosophila embryo
    C Schulz
    Zoologisches Institut, Universitat, Munchen, Germany
    Development 121:1023-8. 1995
    ..this system, we show that the cad domain functions by activating the expression of the abdominal gap genes knirps (kni) and giant (gt)...
  45. ncbi Gap gene properties of the pair-rule gene runt during Drosophila segmentation
    C Tsai
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215
    Development 120:1671-83. 1994
    ..Finally, genetic experiments demonstrated that regulation of gap gene expression by runt is a normal component of the regulatory program that generates the segmented body pattern of the Drosophila embryo...
  46. pmc Silencers in abdominal-B, a homeotic Drosophila gene
    A Busturia
    Zoological Institute, University of Zurich, Switzerland
    EMBO J 12:1415-25. 1993
    ..IAB5 pattern in gap mutants provide evidence that the protein products of the gap genes hunchback, Krüppel and knirps act as repressors through IAB5...
  47. ncbi Disperse versus compact elements for the regulation of runt stripes in Drosophila
    M Klingler
    Zoologisches Institut, Luisenstrasse 14, Munich, D 80333, Germany
    Dev Biol 177:73-84. 1996
    ..Such disperse elements mediating pair-rule gene interactions may have escaped detection in other segmentation genes and may involve molecular mechanisms different from those mediating regulation by gap genes...
  48. ncbi The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation
    S R Russell
    Department of Genetics, University of Cambridge, UK
    Development 122:3669-76. 1996
    ....
  49. ncbi From gradients to stripes in Drosophila embryogenesis: filling in the gaps
    R Rivera-Pomar
    Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Trends Genet 12:478-83. 1996
    ..Recent progress has begun to reveal the mechanisms by which coherent positional information of maternal origin becomes transferred into serially repeated zygotic gene expression domains reflecting the metameric body plan of the larva...
  50. ncbi Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins
    D Kosman
    Brookdale Center for Molecular Biology, Box 1126, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Genes Evol 208:290-4. 1998
    ..Antigenicity of the purified recombinant proteins may be increased by precipitation in double-distilled water. The results of using the serums obtained for fluorescent staining of Drosophila embryos are shown...
  51. ncbi Transcriptional coregulators in development
    M Mannervik
    Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Science 284:606-9. 1999
    ..Recent studies suggest that a growing set of coactivators and corepressors mediate communication between diverse upstream regulatory proteins and the core RNA polymerase II transcription complex...
  52. pmc Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients
    M Fujioka
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 126:2527-38. 1999
    ..border of stripe 6 are set by zygotic hunchback, and the region between the two stripes is 'carved out' by knirps. Thus the boundaries of stripes 4 and 6 are set through negative regulation by the same gap gene domains that ..
  53. ncbi Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene
    M J Shimell
    Department of Genetics, University of Minnesota, Minneapolis, Minnesota, 55455, USA
    Dev Biol 218:38-52. 2000
    ..However, the PHO sites are not sufficient to maintain repression of a homeotic reporter gene anterior to PS7. Full maintenance at late embryonic stages requires additional sequences adjacent to the iab-2(1.7) enhancer...
  54. pmc Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome
    Benjamin P Berman
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:757-62. 2002
    ..We tested one of the newly identified clusters, mapping upstream of the gap gene giant (gt), and show that it acts as an enhancer that recapitulates the posterior expression pattern of gt...
  55. pmc Homotypic regulatory clusters in Drosophila
    Alexander P Lifanov
    Institute of Chemical Physics, Moscow, 117421 Russia
    Genome Res 13:579-88. 2003
    ..We also discuss the potential of the clustering method in interpreting the differential response of genes to various levels of transcriptional regulators...
  56. ncbi Turnover of binding sites for transcription factors involved in early Drosophila development
    Javier Costas
    Instituto de Biologia Molecular e Celular IBMC, Universidade do Porto, Rua do Campo Alegre 823, 4150 180, Porto, Portugal
    Gene 310:215-20. 2003
    ..Finally, we detected a significant decrease in mean PWM scores for the D. virilis binding sites in the case of Hunchback. Possible explanations for this fact are discussed...
  57. pmc Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities
    Jae Ryeon Ryu
    Department of Biochemistry and Molecular Biology and Program in Genetics, Michigan State University, East Lansing, MI 48824 1319, USA
    Nucleic Acids Res 31:4654-62. 2003
    ..To effect repression, Knirps and other short-range repressors bind the CtBP corepressor, but these repressors also function via CtBP-..
  58. ncbi A self-organizing system of repressor gradients establishes segmental complexity in Drosophila
    Dorothy E Clyde
    Biology Department, New York University, New York, New York 10003, USA
    Nature 426:849-53. 2003
    ..Here we show that opposing gradients of two Drosophila transcriptional repressors, Hunchback (Hb) and Knirps (Kni), position several segments by differentially repressing two distinct regulatory regions (enhancers) of the ..
  59. ncbi Dynamic control of positional information in the early Drosophila embryo
    Johannes Jaeger
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York 11794 3600, USA
    Nature 430:368-71. 2004
    ....
  60. ncbi Different combinations of gap repressors for common stripes in Anopheles and Drosophila embryos
    Yury Goltsev
    Department of Molecular and Cellular Biology, Division of Genetics and Development, University of California, Berkeley, CA 94720, USA
    Dev Biol 275:435-46. 2004
    ..We discuss the evolution of separate stripe enhancers in the eve loci of different dipterans...
  61. ncbi Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity
    Outi Hallikas
    Molecular and Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Finland
    Cell 124:47-59. 2006
    ....
  62. pmc Evolution of the nuclear receptor gene superfamily
    V Laudet
    INSERM U186 CNRS URA 1160, Institut Pasteur, Lille, France
    EMBO J 11:1003-13. 1992
    ..but two groups of receptors are in a different position from that in the C domain tree: (i) the Drosophila knirps family genes have acquired very different E domains during evolution, and (ii) the vitamin D and ecdysone ..
  63. ncbi Boundaries and fields in early embryos
    P W Ingham
    Department of Zoology, University of Oxford, England
    Cell 68:221-35. 1992
  64. ncbi The giant gene of Drosophila encodes a b-ZIP DNA-binding protein that regulates the expression of other segmentation gap genes
    M Capovilla
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    Development 114:99-112. 1992
    ..shows that giant, ectopically expressed from the hsp70 promoter, represses the expression of both the Krüppel and knirps segmentation gap genes...
  65. ncbi Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo
    G Bronner
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, F R G
    Mech Dev 35:205-11. 1991
    ..This, in turn, suggests that the terminal gap gene activities prevent metamerization by repression of central gap genes, thereby distinguishing the segmented trunk from the nonsegmented tail region of the embryo...
  66. ncbi Drosophila segmentation: supercomputer simulation of prepattern hierarchy
    A Hunding
    H C Orsted Institute, University of Copenhagen, Denmark
    J Theor Biol 145:369-84. 1990
    ..The study thus suggests that the crucial organizing principle in early Drosophila embryogenesis is based on global field mechanisms, not on particular local interactions...
  67. ncbi A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo
    M Hulskamp
    Institut für Genetik and Mikrobiologie, Universitat Munchen, FRG
    Nature 346:577-80. 1990
    ..anterior and posterior borders of expression of the gap gene Krüppel (Kr) and the anterior border of the gap gene knirps (kni), thus defining three positional values...
  68. ncbi Spatial control of hairy protein expression during embryogenesis
    K L Hooper
    Zoology Department, Oxford University, UK
    Development 107:489-504. 1989
    ..Our observations suggest that pair-rule striping may be under redundant control, and we discuss possible implications for hierarchical models of pair-rule gene action...
  69. ncbi Segmental polarity and identity in the abdomen of Drosophila is controlled by the relative position of gap gene expression
    R Lehmann
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, West Germany
    Development 107:21-9. 1989
    ..The function of the maternal gene products becomes dispensable once the position of the zygotically expressed gap genes is determined. Subsequently the gap genes will control the pattern of the pair-rule and segment polarity genes...
  70. ncbi Krüppel requirement for knirps enhancement reflects overlapping gap gene activities in the Drosophila embryo
    M J Pankratz
    Institut fur Genetik und Mikrobiologie, Munchen, FRG
    Nature 341:337-40. 1989
    ..Here we describe the interactions between the gap genes Krüppel (Kr), knirps (kni) and tailless (tll)...
  71. pmc Gap genes define the limits of antennapedia and bithorax gene expression during early development in Drosophila
    K Harding
    Department of Biological Sciences Fairchild Center, Columbia University, New York, NY 10027
    EMBO J 7:205-14. 1988
    ..We propose that the gap genes are largely responsible for integrating the processes of segmentation and homeosis...
  72. ncbi Model for cooperative control of positional information in Drosophila by bicoid and maternal hunchback
    J Reinitz
    Center for Medical Informatics, Yale Medical School, New Haven, Connecticut 06510
    J Exp Zool 271:47-56. 1995
    ..The model shows that positional information in the presumptive middle body is cooperatively determined by maternal products of the bicoid and hunchback genes...
  73. pmc Differential regulation of target genes by different alleles of the segmentation gene hunchback in Drosophila
    M Hulskamp
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, Federal Republic of Germany
    Genetics 138:125-34. 1994
    ..which the HB protein lacks a functional second finger domain, the regulation of the target genes Krüppel (Kr) and knirps (kni) is differentially affected...
  74. pmc Redundant functions of the genes knirps and knirps-related for the establishment of anterior Drosophila head structures
    M Gonzalez-Gaitan
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Proc Natl Acad Sci U S A 91:8567-71. 1994
    ..We found that the evolutionarily related genes knirps (kni) and knirps-related (knrl) contribute to a similar phenomenon in Drosophila...
  75. ncbi Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes
    T Gutjahr
    Institute of Molecular Biology II, University of Zurich, Switzerland
    Development 117:609-23. 1993
    ..runt and hairy, and in all gap mutants suggests that the products of the gap genes hunchback, Krüppel, knirps and giant activate paired expression in stripes...
  76. ncbi Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo
    S Small
    Department of Biology, New York University, New York 10003, USA
    Dev Biol 175:314-24. 1996
    ..b>knirps, a member of the nuclear receptor family of transcription factors, appears to establish the posterior border of ..
  77. ncbi Concentration-dependent patterning by an ectopic expression domain of the Drosophila gap gene knirps
    D Kosman
    Department of Biology, New York University, NY 10003, USA
    Development 124:1343-54. 1997
    The asymmetric distribution of the gap gene knirps (kni) in discrete expression domains is critical for striped patterns of pair-rule gene expression in the Drosophila embryo...
  78. ncbi DPP controls tracheal cell migration along the dorsoventral body axis of the Drosophila embryo
    S Vincent
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Switzerland
    Development 124:2741-50. 1997
    ..It is required to control the dorsal expression of the BNL ligand; in addition, the DPP signal recruits groups of dorsal and ventral tracheal cells and programs them to migrate in dorsal and ventral directions...
  79. ncbi A cascade of transcriptional control leading to axis determination in Drosophila
    D Niessing
    Abteilung Molekulare Entwick lungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    J Cell Physiol 173:162-7. 1997
  80. ncbi Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression
    Z Paroush
    Imperial Cancer Research Fund, London, UK
    Development 124:3827-34. 1997
    ..ectopic tll and hkb transcription; the former leads, in turn, to lack of abdominal expression of the Krüppel and knirps gap genes...
  81. ncbi Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos
    S Greenwood
    Howard Hughes Medical Institute, and Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 124:4879-86. 1997
    ....
  82. ncbi Stripe forming architecture of the gap gene system
    J Reinitz
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, NY 10029, USA
    Dev Genet 23:11-27. 1998
    ..It is argued that the constraints on gap gene architecture identified here are a consequence of selective pressures that minimize the number of gap genes required to determine segments in long-germ band insects...
  83. pmc Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo
    D S Burz
    Molecular Genetics Program, Wadsworth Center, New York State Department of Health and Department of Biomedical Sciences, State University of New York Albany, NY 12208, USA
    EMBO J 17:5998-6009. 1998
    ..no significant difference between the affinity of Bicoid for the anterior gene hunchback and the posterior gene knirps. We propose, instead, that the arrangement of Bicoids bound to the target gene presents a unique signature to the ..
  84. ncbi The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development
    C K Chen
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Am Fassberg, D 37077 Gottingen, Germany
    Development 125:4959-68. 1998
    ..We show that two genes encoding the transcription factors KNIRPS and KNIRPS RELATED possess multiple and redundant functions during tracheal development...
  85. ncbi The Drosophila semushi mutation blocks nuclear import of bicoid during embryogenesis
    J L Epps
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    Curr Biol 8:1277-80. 1998
    ..Consequently, semi embryos have multiple defects in anterior segmentation. This study demonstrates that an E2 enzyme is required for nuclear transport during Drosophila embryogenesis...
  86. ncbi Wingless and its signalling pathway have common and separable functions during tracheal development
    M Llimargas
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 127:4407-17. 2000
    ..The results suggest that another gene product, possibly a WNT, could help to trigger the wingless cascade in the developing tracheae...
  87. ncbi Thoracic patterning by the Drosophila gap gene hunchback
    X Wu
    Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA
    Dev Biol 237:79-92. 2001
    ..gradient is critical for establishing the positions of several target genes, including the gap genes Kruppel (Kr), knirps (kni), and giant (gt), and the homeotic gene Ultrabithorax (Ubx)...
  88. ncbi ribbon encodes a novel BTB/POZ protein required for directed cell migration in Drosophila melanogaster
    P L Bradley
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, Maryland 21205 2196, USA
    Development 128:3001-15. 2001
    ..Directed cell migration of the salivary gland and dorsal epidermis are also affected in ribbon mutants, suggesting that conserved mechanisms may be employed to orient cell migrations in multiple tissues during development...
  89. ncbi Transcriptional repression: the long and the short of it
    A J Courey
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 15:2786-96. 2001
  90. pmc Seven Wnt homologues in Drosophila: a case study of the developing tracheae
    M Llimargas
    Institut de Biologia Molecular de Barcelona IBMB, Consejo Superior de Investigaciones Cientificas CSIC, C Jordi Girona 18 26, 08034 Barcelona, Spain
    Proc Natl Acad Sci U S A 98:14487-92. 2001
    ..We suggest that the main advantage of retaining a number of similar genes is that it allows more subtle forms of control and more flexibility during evolution...
  91. ncbi Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes
    Sheng Zhang
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA
    Cell 108:45-56. 2002
    ..We propose that Atrophin proteins function as versatile transcriptional corepressors and discuss a model that deregulation of transcription may contribute to the pathogenesis of neurodegeneration...
  92. ncbi Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development
    Alfrun Erkner
    Laboratoire de Genetique et Physiologie du Developpement, UMR 9943 C N R S Université, I B D M CNRS INSERM Université de la Méditerranée, Campus de Luminy Case 907, F 13288 Marseille, Cedex 09, France
    Development 129:1119-29. 2002
    ..Grunge has other regulatory functions in the leg, including the patterning of ventral parts along the entire proximodistal axis and the proper spacing of bristles in all regions...
  93. pmc Extraction of functional binding sites from unique regulatory regions: the Drosophila early developmental enhancers
    Dmitri A Papatsenko
    Department of Biology, New York University, New York, NY 10003 6688, USA
    Genome Res 12:470-81. 2002
    ..We also discuss the definition of true binding sites and the possible biological principles that govern patterning of regulatory regions and the distribution of transcriptional signals...
  94. ncbi FlyMove--a new way to look at development of Drosophila
    Katrin Weigmann
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Trends Genet 19:310-1. 2003
    ..Here, we introduce FlyMove (http://flymove.uni-muenster.de), a new database combining movies, animated schemata, interactive "modules" and pictures that will greatly facilitate the understanding of Drosophila development...
  95. pmc Dynamical analysis of regulatory interactions in the gap gene system of Drosophila melanogaster
    Johannes Jaeger
    Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794 3600, USA
    Genetics 167:1721-37. 2004
    ..Finally, our models suggest a correlation between timing of gap domain boundary formation and regulatory contributions from the terminal maternal system...
  96. pmc cis-regulatory logic of short-range transcriptional repression in Drosophila melanogaster
    Meghana M Kulkarni
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
    Mol Cell Biol 25:3411-20. 2005
    ..This cis-regulatory "grammar" may aid the identification of enhancers regulated by short-range repressors and facilitate bioinformatic prediction of the functional output of transcriptional regulatory sequences...
  97. pmc Functional interaction between the Drosophila knirps short range transcriptional repressor and RPD3 histone deacetylase
    Paolo Struffi
    Department of Biochemistry and Molecular Biology and Program in Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 280:40757-65. 2005
    b>Knirps and other short range transcriptional repressors play critical roles in patterning the early Drosophila embryo...
  98. pmc Mis-specified cells die by an active gene-directed process, and inhibition of this death results in cell fate transformation in Drosophila
    Christian Werz
    The University of Texas M D Anderson Cancer Center, Department of Biochemistry and Molecular Biology, 1515 Holcombe Boulevard, Unit 1000, Houston, TX 77030, USA
    Development 132:5343-52. 2005
    ..These data support a model whereby mis-specification can be tolerated if a survival pathway is provided, resulting in cellular transformation...
  99. pmc Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors
    Lei Wang
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Genes Dev 20:525-30. 2006
    ..Using the established regulation of knirps by tll as a paradigm, we report that repression of knirps by Tll involves Atrophin, which is related to vertebrate ..
  100. ncbi Sexual reproduction selects for robustness and negative epistasis in artificial gene networks
    Ricardo B R Azevedo
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Nature 440:87-90. 2006
    ..Our results suggest that sexual reproduction selects for conditions that favour its own maintenance, a case of evolution forging its own path...

Research Grants5

  1. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  2. A new site-specific recombination system in Drosophila
    Georg Halder; Fiscal Year: 2005
    ..These tools will have broad applications and will lead to the discovery of novel genetic interactions in Drosophila that could not have been detected using currently available methods. ..
  3. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
  4. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  5. SUMO conjugation in cell biology and Development
    Albert J Courey; Fiscal Year: 2010
    ..Consequently, the research proposed here will advance our understanding of human disease. ..