InR

Summary

Gene Symbol: InR
Description: Insulin-like receptor
Alias: 18402, CG18402, DIHR, DILR, DIR, DIRH, DIRbeta, DInR, DInr, Dir-a, Dir-b, Dmel\CG18402, INR, INS, Inr, Inr-alpha, Inr-beta, InsR, dINR, dIR, dIRH, dInR, dInr, dInsR, dinr, dir, er10, inR, inr, insulin/insulin-like growth factor receptor, l(3)05545, l(3)93Dj, l(3)er10, lnR, sprout, CG18402 gene product from transcript CG18402-RB, CG18402-PA, CG18402-PB, CG18402-PC, CG18402-PD, InR-PA, InR-PB, InR-PC, InR-PD, Insulin-receptor, drosophila insulin receptor, insulin, insulin receptor, insulin receptor homolog, insulin receptor homologue, insulin-like receptor, lethal(3)93Dj, sprout
Species: fruit fly

Top Publications

  1. ncbi Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
  2. ncbi Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
    X Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235 9040, USA
    Dev Biol 221:404-18. 2000
  3. pmc Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster
    Sergey V Nuzhdin
    Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
    BMC Genomics 10:124. 2009
  4. ncbi Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
    Sean Oldham
    The Burnham Institute, La Jolla, CA 92037, USA
    Trends Cell Biol 13:79-85. 2003
  5. pmc The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
    Christian Werz
    Institute of Molecular Systems Biology, Zurich, Switzerland
    PLoS Genet 5:e1000596. 2009
  6. pmc The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling
    Stefanie K Tiefenböck
    ETH Zurich, Department of Biology, Zurich, Switzerland
    EMBO J 29:171-83. 2010
  7. ncbi Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
    R Bohni
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 97:865-75. 1999
  8. pmc Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway
    Oscar Puig
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Genes Dev 17:2006-20. 2003
  9. pmc Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells
    Jenn Yah Yu
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Development 136:1497-507. 2009
  10. ncbi Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
    Ya Chieh Hsu
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 445:785-8. 2007

Research Grants

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. ncbi Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
    The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway...
  2. ncbi Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways
    X Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235 9040, USA
    Dev Biol 221:404-18. 2000
    ..Furthermore, we show that dPTEN does not play a major role in cell survival during Drosophila development. Our results provide a potential explanation for the high frequency of PTEN mutation in human cancer...
  3. pmc Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster
    Sergey V Nuzhdin
    Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
    BMC Genomics 10:124. 2009
    ..We focus on the latter problem by describing genetic variation in transcript levels of genes in the InR/TOR pathway among 72 Drosophila melanogaster genotypes.
  4. ncbi Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
    Sean Oldham
    The Burnham Institute, La Jolla, CA 92037, USA
    Trends Cell Biol 13:79-85. 2003
    ..One major orchestrator of this complex growth process in diverse metazoan species is the insulin/insulin-like growth factor (IGF) system...
  5. pmc The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
    Christian Werz
    Institute of Molecular Systems Biology, Zurich, Switzerland
    PLoS Genet 5:e1000596. 2009
    ..Genetic epistasis analysis places lnk downstream of the insulin receptor (InR) and upstream of phosphoinositide 3-kinase (PI3K) in the IIS cascade, at the same level as chico (..
  6. pmc The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling
    Stefanie K Tiefenböck
    ETH Zurich, Department of Biology, Zurich, Switzerland
    EMBO J 29:171-83. 2010
    ..fat body, Spargel mediated mitochondrial activity, cell growth and transcription of target genes in response to insulin signalling...
  7. ncbi Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
    R Bohni
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 97:865-75. 1999
    ..The similarities of the growth defects caused by mutations in chico and the insulin receptor gene in Drosophila and by perturbations of the insulin/IGF1 signaling pathway in vertebrates suggest that ..
  8. pmc Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway
    Oscar Puig
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Genes Dev 17:2006-20. 2003
    The Drosophila insulin receptor (dInR) regulates cell growth and proliferation through the dPI3K/dAkt pathway, which is conserved in metazoan organisms...
  9. pmc Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells
    Jenn Yah Yu
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Development 136:1497-507. 2009
    ..We report that intrinsic and extrinsic regulators intersect in GSC division control; the Insulin receptor (InR) pathway regulates Dap levels through miRNAs, thereby controlling GSC division...
  10. ncbi Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
    Ya Chieh Hsu
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 445:785-8. 2007
    ..Our studies identify TCTP as a direct regulator of Rheb and a potential therapeutic target for TSC disease...
  11. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2009
    The insulin signalling pathway is highly conserved from mammals to Drosophila...
  12. pmc Insulin signalling regulates remating in female Drosophila
    Stuart Wigby
    Institute of Healthy Ageing and, Department of Genetics, Evolution and Environment, University College London, UK
    Proc Biol Sci 278:424-31. 2011
    ..The evolutionarily conserved insulin/insulin-like growth factor-like signalling (IIS) pathway is responsive to nutrition, and regulates development, ..
  13. ncbi Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
    Jessica S Britton
    Molecular and Cellular Biology Program, Seattle, WA 98109, USA
    Dev Cell 2:239-49. 2002
    Studies in Drosophila have characterized insulin receptor/phosphoinositide 3-kinase (Inr/PI3K) signaling as a potent regulator of cell growth, but its function during development has remained uncertain...
  14. pmc Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning
    Ji Hoon Lee
    Section of Molecular Cell and Developmental Biology, Institute for Cell and Molecular Biology, The University of Texas at Austin, 1 University Station A4800, Austin, TX 78712, USA
    Dev Biol 331:1-13. 2009
    ..In addition, primarily by analyzing mutant eye discs, we found that lqfR is required for cell proliferation, insulin-independent cell growth, and cell patterning, consistent with a role in one or several signaling pathways...
  15. ncbi The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels
    Sean Oldham
    Universitat Zurich, Zoologisches Institut, Winterthurerstrasse 190, CH 8057, Switzerland
    Development 129:4103-9. 2002
    Understanding the control of size is of fundamental biological and clinical importance. Insulin/IGF signaling during development controls growth and size, possibly by coordinating the activities of the Ras and PI 3-kinase signaling ..
  16. pmc Tissue localization of Drosophila melanogaster insulin receptor transcripts during development
    R S Garofalo
    Program in Molecular Biology, Memorial Sloan Kettering Cancer Research Center, New York, New York
    Mol Cell Biol 8:1638-47. 1988
    The Drosophila melanogaster insulin receptor (Drosophila insulin receptor homolog [dIRH]) is similar to its mammalian counterpart in deduced amino acid sequence, subunit structure, and ligand-stimulated protein tyrosine kinase activity...
  17. pmc Structure and ligand specificity of the Drosophila melanogaster insulin receptor
    R Fernandez-Almonacid
    Memorial Sloan Kettering Cancer Center, New York, New York
    Mol Cell Biol 7:2718-27. 1987
    The insulin-binding and protein tyrosine kinase subunits of the Drosophila melanogaster insulin receptor homolog have been identified and characterized by using antipeptide antibodies elicited to the deduced amino acid sequence of the ..
  18. ncbi The Drosophila insulin receptor is required for normal growth
    C Chen
    Department of Anatomy and Cell Biology, State University of New York, Brooklyn, New York 11203, USA
    Endocrinology 137:846-56. 1996
    Drosophila contain an insulin receptor homologue, encoded by the inr gene located at position 93E4-5 on the third chromosome...
  19. ncbi Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
    C J Potter
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA
    Cell 105:357-68. 2001
    ..Genetic epistasis data are consistent with a model that Tsc1 and Tsc2 function together in the insulin signaling pathway.
  20. ncbi Impaired ovarian ecdysone synthesis of Drosophila melanogaster insulin receptor mutants
    Meng Ping Tu
    Brown University, Providence, Rhode Island 02912, USA
    Aging Cell 1:158-60. 2002
  21. pmc Identification of co-regulated transcripts affecting male body size in Drosophila
    Cynthia J Coffman
    Health Services Research and Development Biostatistics Unit, Durham VA Medical Center 152, Durham, NC 27705, USA
    Genome Biol 6:R53. 2005
    ..Applied to body size in Drosophila simulans, an evolutionarily important complex trait, a factor was directly associated with body size...
  22. ncbi Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila
    Leesa LaFever
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4120B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232 8240, USA
    Science 309:1071-3. 2005
    ..Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating ..
  23. pmc Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
    b>Insulin and insulin-like growth factors (IGFs) signal through a highly conserved pathway and control growth and metabolism in both vertebrates and invertebrates...
  24. pmc Regulation of neurogenesis and epidermal growth factor receptor signaling by the insulin receptor/target of rapamycin pathway in Drosophila
    Helen McNeill
    The Wolfson Centre for Age Related Diseases, King s College, London SE1 1UL, United Kingdom
    Genetics 179:843-53. 2008
    ..We have previously shown that growth and neuronal differentiation are coordinated by the insulin receptor/target of rapamycin (TOR) kinase (InR/TOR) pathway...
  25. pmc Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
    Richard C Grandison
    Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, UK
    Nature 462:1061-4. 2009
    ..Reduced activity of the insulin/insulin-like growth factor signalling pathway extends lifespan in diverse organisms, and we find that it also ..
  26. pmc A Drosophila insulin-like peptide promotes growth during nonfeeding states
    Maija Slaidina
    Institute for Developmental Biology and Cancer, University of Nice Sophia Antipolis Centre National de la Recherche Scientifique, Parc Valrose, 06108 Nice, France
    Dev Cell 17:874-84. 2009
    ..availability of nutrients--stored internally or obtained from the environment--and the resulting activation of insulin/IGF signaling (IIS)...
  27. pmc The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential
    R Fernandez
    Department of Pharmacology, New York University Medical Center, NY 10016, USA
    EMBO J 14:3373-84. 1995
    We report the cloning and primary structure of the Drosophila insulin receptor gene (inr), functional expression of the predicted polypeptide, and the isolation of mutations in the inr locus...
  28. ncbi PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
    H Huang
    Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536 0812, USA
    Development 126:5365-72. 1999
    ..Furthermore, we have shown that PTEN acts in the insulin signaling pathway and all signals from the insulin receptor can be antagonized by either Drosophila or human PTEN, suggesting a potential means for alleviating symptoms ..
  29. ncbi Regulation of aversion to noxious food by Drosophila neuropeptide Y- and insulin-like systems
    Qi Wu
    Department of Cellular Biology and Biomedical and Health Sciences Institute, University of Georgia, 724 Biological Sciences Building, Athens, Georgia 30602, USA
    Nat Neurosci 8:1350-5. 2005
    ..Moreover, NPFR1 neuronal activity may be directly regulated by the insulin-like signaling pathway...
  30. pmc The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis
    L Yenush
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 16:2509-17. 1996
    The Drosophila insulin receptor (DIR) contains a 368-amino-acid COOH-terminal extension that contains several tyrosine phosphorylation sites in YXXM motifs...
  31. ncbi Measuring dimensions: the regulation of size and shape
    S J Day
    28 St Oswalds Road, York, YO10 4PF, UK
    Development 127:2977-87. 2000
    ..We discuss a hypothesis that the local steepness of a morphogen gradient is a measure of length in one axis, a measure that is used to determine whether there will be net growth or not...
  32. pmc Genetic control of size in Drosophila
    S Oldham
    Zoological Institute, University of Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 355:945-52. 2000
    ..In this article we will review recent evidence from vertebrates and particularly from Drosophila that implicates insulin/insulin-like growth factor-I and other growth pathways in the control of cell, organ and body size.
  33. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
    ..in Drosophila have identified an evolutionarily conserved signaling pathway that regulates organismal size and that includes the Drosophila insulin receptor substrate homolog Chico, the lipid kinase PI(3)K (Dp110), DAkt1/dPKB, and dS6K.
  34. ncbi A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    M Tatar
    Brown University, Providence, RI 02912, USA, University of Massachusetts, Amherst, MA 01003, USA
    Science 292:107-10. 2001
    The Drosophila melanogaster gene insulin-like receptor (InR) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf-2, a signal transducer regulating worm dauer formation and adult longevity...
  35. pmc TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    X Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    Genes Dev 15:1383-92. 2001
    ..strikingly, the heterozygosity of TSC1 or TSC2 is sufficient to rescue the lethality of loss-of-function insulin receptor mutants...
  36. pmc PDK1 regulates growth through Akt and S6K in Drosophila
    F Rintelen
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 98:15020-5. 2001
    The insulin/insulin-like growth factor-1 signaling pathway promotes growth in invertebrates and vertebrates by increasing the levels of phosphatidylinositol 3,4,5-triphosphate through the activation of p110 phosphatidylinositol 3-kinase...
  37. ncbi Molecular genetics of aging in the fly: is this the end of the beginning?
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030 3301, USA
    Bioessays 25:134-41. 2003
    ....
  38. pmc The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    Martin A Jünger
    Zoologisches Institut, Universitat Zurich, Winterthurerstr, 190, CH 8057 Zurich, Switzerland
    J Biol 2:20. 2003
    ..belonging to the FOXO subfamily are negatively regulated by protein kinase B (PKB) in response to signaling by insulin and insulin-like growth factor in Caenorhabditis elegans and mammals...
  39. ncbi Genetics of aging in the fruit fly, Drosophila melanogaster
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3301, USA
    Annu Rev Genet 37:329-48. 2003
    ....
  40. ncbi Role and regulation of starvation-induced autophagy in the Drosophila fat body
    Ryan C Scott
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis 55455 USA
    Dev Cell 7:167-78. 2004
    ..Thus, in cells lacking TOR, autophagy plays a protective role that is dominant over its potential role as a growth suppressor...
  41. ncbi Insulin regulation of heart function in aging fruit flies
    Robert J Wessells
    The Burnham Institute, Center for Neuroscience and Aging, 10901 Torrey Pines Road, La Jolla, California 92037, USA
    Nat Genet 36:1275-81. 2004
    b>Insulin-IGF receptor (InR) signaling has a conserved role in regulating lifespan, but little is known about the genetic control of declining organ function...
  42. ncbi Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster
    Ammon B Corl
    Department of Anatomy and Programs, University of California, San Francisco, California 94143 2822, USA
    Nat Neurosci 8:18-9. 2005
    The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction...
  43. ncbi Sex and death: what is the connection?
    Linda Partridge
    UCL Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    Cell 120:461-72. 2005
    ..Mutations in insulin/IGF signaling (IIS) pathways and dietary restriction (DR) can extend lifespan in model organisms but do not ..
  44. ncbi JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
    Meng C Wang
    Department of Biomedical Genetics, The Aab Institute of Biomedical Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, New York 14642, USA
    Cell 121:115-25. 2005
    ..When nutrients are abundant, the insulin/IGF signaling (IIS) pathway promotes growth and energy storage but shortens life span...
  45. ncbi PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Development 132:2365-75. 2005
    ..in normal and tumour cells is regulated by evolutionarily conserved extracellular inputs from the endocrine insulin receptor (InR) signalling pathway and by local nutrients...
  46. pmc The temporal requirements for insulin signaling during development in Drosophila
    Alexander W Shingleton
    Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Biol 3:e289. 2005
    ..Using a temperature-sensitive insulin receptor (Inr) mutation in Drosophila, we show that the developmental requirements for Inr activity are organ specific ..
  47. pmc Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila
    Qi Wu
    Department of Cellular Biology, and Biomedical and Health Sciences Institute, University of Georgia, 724 Biological Sciences Building, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 102:13289-94. 2005
    ..Here, we report on the function and mechanism of the Drosophila insulin-like system in the central regulation of different hunger-driven behaviors...
  48. ncbi Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005
    ..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
  49. ncbi Disruption of insulin pathways alters trehalose level and abolishes sexual dimorphism in locomotor activity in Drosophila
    Yesser Hadj Belgacem
    Equipe ATIPE Bases Neurales du Mouvement chez la Drosophile, NAMC, CNRS, UMR 8620, Universite Paris Sud, Batiment 446, F 91405, Orsay, France
    J Neurobiol 66:19-32. 2006
    ..Moreover, we also show that in the head of adult flies, the insulin receptor (InR) is expressed only in the fat body surrounding the brain...
  50. pmc Transcriptional feedback control of insulin receptor by dFOXO/FOXO1
    Oscar Puig
    Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Genes Dev 19:2435-46. 2005
    ..Here we show that, both in Drosophila and mammals, insulin receptor (InR) represses its own synthesis by a feedback mechanism directed by the transcription factor dFOXO/FOXO1...
  51. ncbi Age-independent synaptogenesis by phosphoinositide 3 kinase
    Alfonso Martín-Peña
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 26:10199-208. 2006
    ..Thus, we propose that PI3K stimulation can be applied to prevent or delay synapse loss in normal aging and in neurological disorders...
  52. pmc Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation
    Xi Luo
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    EMBO J 26:380-90. 2007
    ..These data suggest that integrating stress and survival signals through Foxo drives the decision between cell death and repair of damaged cells in vivo...
  53. pmc IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback
    Michael T Marr
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA
    Genes Dev 21:175-83. 2007
    ..The Drosophila insulin-like receptor (dINR) pathway incorporates 4E-BP resistant cellular internal ribosome entry site (IRES) containing ..
  54. pmc Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila
    Yesser Hadj Belgacem
    Laboratoire de Neurobiologie Cellulaire et Moléculaire NBCM, Centre National de la Recherche Scientifique CNRS, Unité UPR 9040, Gif sur Yvette, France
    PLoS ONE 2:e187. 2007
    ..In Drosophila, mutations in the insulin receptor (InR) decrease the rate of JH synthesis...
  55. ncbi Dynamics of the action of dFOXO on adult mortality in Drosophila
    Maria E Giannakou
    Centre for Research on Ageing, Department of Biology, University College London, London, UK
    Aging Cell 6:429-38. 2007
    The insulin/insulin growth factor (IGF)-like signaling (IIS) pathway has a conserved role in regulating lifespan in Caenorhabditis elegans, Drosophila and mice. Extension of lifespan by reduced IIS has been shown in C...
  56. ncbi Quantitative proteomic analysis of protein complexes: concurrent identification of interactors and their state of phosphorylation
    Delphine Pflieger
    Institute for Molecular Systems Biology, ETH, 8093 Zurich, Switzerland
    Mol Cell Proteomics 7:326-46. 2008
    ..of samples immunopurified from Drosophila melanogaster cells expressing an epitope-tagged form of the insulin receptor substrate homologue Chico...
  57. pmc Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila
    Hwei Jan Hsu
    Department of Cell and Developmental Biology, 4120B Medical Research Building III, Vanderbilt University Medical Center, 465 21st Avenue South, Nashville, TN 37232 8240, USA
    Dev Biol 313:700-12. 2008
    ..Our previous work showed that germline stem cells (GSCs) respond to diet via neural insulin-like peptides (DILPs) that act directly on the germ line to upregulate stem cell division and cyst growth under a ..
  58. doi Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling
    Susanne Buch
    Institute of Genetics, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
    Cell Metab 7:321-32. 2008
    Specific neurosecretory cells of the Drosophila brain express insulin-like peptides (dilps), which regulate growth, glucose homeostasis, and aging...
  59. doi Imaginal discs regulate developmental timing in Drosophila melanogaster
    Bradley C Stieper
    Department of Zoology, Michigan State University, East Lansing, Michigan 48824, USA
    Dev Biol 321:18-26. 2008
    ....
  60. pmc Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
    Susan Broughton
    UCL Institute of Healthy Ageing, GEE, University College London, London, UK
    PLoS ONE 3:e3721. 2008
    The insulin/IGF-like signalling (IIS) pathway has diverse functions in all multicellular organisms, including determination of lifespan...
  61. pmc Tissue damage-induced intestinal stem cell division in Drosophila
    Alla Amcheslavsky
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Stem Cell 4:49-61. 2009
    ..By using this newly established system of intestinal stem cell proliferation and tissue regeneration, we find that the insulin receptor signaling pathway is required for intestinal stem cell division.
  62. pmc Insulin levels control female germline stem cell maintenance via the niche in Drosophila
    Hwei Jan Hsu
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 8240, USA
    Proc Natl Acad Sci U S A 106:1117-21. 2009
    ..Here, we show that insulin signaling integrates the effects of diet and age on germline stem cell (GSC) maintenance through the dual ..
  63. pmc Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila
    Fabio Demontis
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 136:983-93. 2009
    ..Inhibition of Insulin receptor (InR; Insulin-like receptor) signaling in muscles autonomously reduces muscle size and systemically affects ..
  64. pmc The ecdysone receptor controls the post-critical weight switch to nutrition-independent differentiation in Drosophila wing imaginal discs
    Christen K Mirth
    Department of Biology, Box 351800, University of Washington, Seattle, WA 98195, USA
    Development 136:2345-53. 2009
    ..Previously, we found that reaching critical weight depends on the insulin-dependent growth of the prothoracic glands (PGs) in Drosophila larvae...
  65. pmc The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila
    Tomoatsu Ikeya
    UCL Institute of Healthy Ageing and GEE, University College London, Darwin Building, Gower Street, London, UK
    Proc Biol Sci 276:3799-807. 2009
    b>Insulin/IGF-like signalling (IIS) is an evolutionarily conserved pathway that has diverse functions in multi-cellular organisms...
  66. doi Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K
    Seogang Hyun
    School of Biological Sciences and National Creative Research Center, Seoul National University, Seoul, 151 742, Korea
    Cell 139:1096-108. 2009
    ..miR-8 null flies are smaller in size and defective in insulin signaling in fat body that is the fly counterpart of liver and adipose tissue...
  67. pmc SH2B regulation of growth, metabolism, and longevity in both insects and mammals
    Wei Song
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Metab 11:427-37. 2010
    ..Here, we identified dSH2B as the Drosophila homolog of SH2B1. dSH2B bound to Chico and directly promoted insulin-like signaling. Disruption of dSH2B decreased insulin-like signaling and somatic growth in flies...
  68. doi Sex peptide receptor and neuronal TOR/S6K signaling modulate nutrient balancing in Drosophila
    Carlos Ribeiro
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 20:1000-5. 2010
    ..We propose that the brain uses these internal states to assign value to external sensory information from potential food sources, thereby guiding food choice and ensuring nutrient homeostasis...
  69. pmc Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling
    Lutz Kockel
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1000990. 2010
    Akt represents a nodal point between the Insulin receptor and TOR signaling, and its activation by phosphorylation controls cell proliferation, cell size, and metabolism...
  70. pmc Structural and biological properties of the Drosophila insulin-like peptide 5 show evolutionary conservation
    Waseem Sajid
    Receptor Systems Biology Laboratory, Insulin and Incretin Biology, Hagedorn Research Institute, 2820 Gentofte, Denmark
    J Biol Chem 286:661-73. 2011
    ..It also lowers trehalose levels in Drosophila. Reciprocally, human insulin binds to the Drosophila insulin receptor and induces negative cooperativity as in the human receptor...
  71. doi Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands
    Hwei Jan Hsu
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 350:290-300. 2011
    ..We previously showed that insulin signals directly stimulate germline stem cell (GSC) division and indirectly promote GSC maintenance via the niche ..
  72. pmc Nutrition-responsive glia control exit of neural stem cells from quiescence
    James M Chell
    The Gurdon Institute and Department of Physiology, Development, and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 143:1161-73. 2010
    ..We have identified a population of glial cells that produce insulin/IGF-like peptides in response to nutrition, and we show that the insulin/IGF receptor pathway is necessary for ..
  73. pmc Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    Rita Sousa-Nunes
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 471:508-12. 2011
    ..Downstream of this signal, Insulin-like receptor signalling and the Phosphatidylinositol 3-kinase (PI3K)/TOR network are required in neuroblasts for ..
  74. pmc Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search
    Cory M Root
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 145:133-44. 2011
    ..We found that a local signal by short neuropeptide F (sNPF) and a global metabolic cue by insulin are integrated at specific odorant receptor neurons (ORNs) to modulate olfactory sensitivity...
  75. doi Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model
    M Willecke
    Institute of Molecular Life Sciences, University of Zurich, Switzerland
    Oncogene 30:4067-74. 2011
    ..The results presented here broaden our insights into the intricate mechanisms underling tumorigenesis and illustrate the power of Drosophila genetics in revealing weak points of tumor progression...
  76. doi Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila
    Louise Y Cheng
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Cell 146:435-47. 2011
    ..kinase (Alk) efficiently protects neural progenitor (neuroblast) growth against reductions in amino acids and insulin-like peptides during NR via two mechanisms...
  77. doi Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing
    Gilles Storelli
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR 6216 Aix Marseille Universités, 13288 Marseille, France
    Cell Metab 14:403-14. 2011
    ..Our results indicate that the intestinal microbiota should also be envisaged as a factor that influences the systemic growth of its host...
  78. pmc Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
    Timo Glatter
    Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
    Mol Syst Biol 7:547. 2011
    ..Many of these genes encode components of the insulin receptor/target of rapamycin (InR/TOR) pathway...
  79. pmc Role of the insulin/Tor signaling network in starvation-induced programmed cell death in Drosophila oogenesis
    T L Pritchett
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Cell Death Differ 19:1069-79. 2012
    ..Disruption of insulin signaling has been shown to inhibit the progression of oogenesis, but it is unclear whether this phenotype mimics ..
  80. pmc MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila
    Wei Zhang
    Institute of Molecular and Cell Biology, Singapore, Singapore
    PLoS Genet 7:e1002429. 2011
    The insulin/IGF-activated AKT signaling pathway plays a crucial role in regulating tissue growth and metabolism in multicellular animals...
  81. pmc Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila
    Lynne Marshall
    Department of Biochemistry and Molecular Biology, Clark H Smith Brain Tumour Centre, Southern Alberta Cancer Research Institute, University of Calgary, HRIC, Calgary, Alberta, Canada
    EMBO J 31:1916-30. 2012
    ..TOR activity in the larval fat body, a tissue equivalent to vertebrate fat or liver, couples nutrition to insulin release from the brain...
  82. doi Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP
    Katrin Straßburger
    German Cancer Research Center, DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Dev Biol 367:187-96. 2012
    The insulin/IGF signaling (IIS) pathway is a potent inducer of cell proliferation in normal development and in cancer. The mechanism by which this occurs, however, is not completely understood...
  83. pmc Controlling animal growth and body size - does fruit fly physiology point the way?
    Savraj S Grewal
    Clark Smith Brain Tumor Center, Southern Alberta Cancer Research Institute, Department of Biochemistry and Molecular Biology, University of Calgary Alberta, T2N 1N4 Canada
    F1000 Biol Rep 4:12. 2012
    ..While this concept is obviously not new, these fly studies now open up the possibility of using a genetically tractable system to dissect in detail how organ-to-organ communication dictates body size...
  84. doi Insulin signalling in mushroom body neurons regulates feeding behaviour in Drosophila larvae
    Xiao Li Zhao
    Department of Biology, McMaster University, Hamilton, ON, Canada
    J Exp Biol 215:2696-702. 2012
    ..organization of the Drosophila larval brain and the availability of genetic tools to impair the function of insulin receptor signalling in a spatially specific manner makes Drosophila an attractive model to investigate the role of the ..
  85. pmc Interaction between sleep and metabolism in Drosophila with altered octopamine signaling
    Renske Erion
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:32406-14. 2012
    ..Octopamine promotes wakefulness in the fly by acting through the insulin-producing cells (IPCs) in the fly brain...
  86. pmc A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila
    Naoki Okamoto
    Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology, Chuo Ku, Hyogo, Japan
    Genes Dev 27:87-97. 2013
    Members of the insulin peptide family have conserved roles in the regulation of growth and metabolism in a wide variety of metazoans...
  87. doi bantam miRNA promotes systemic growth by connecting insulin signaling and ecdysone production
    Laura Boulan
    Institute for Research in Biomedicine IRB Barcelona, Carrer de Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 23:473-8. 2013
    ..The antagonistic action of ecdysone and the conserved insulin/insulin growth factor (IGF) signaling pathway regulate systemic growth and modulate final body size [2, 3]...
  88. pmc Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila
    Jason Karpac
    Department of Biology, University of Rochester, Rochester, NY 14627, USA Buck Institute for Research on Aging, Novato, CA 94945, USA Electronic address
    Cell Rep 4:1250-61. 2013
    ..We find that activation of the insulin-responsive transcription factor Foxo in intestinal enterocytes is required to inhibit the expression of ..
  89. pmc Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching
    Gerit A Linneweber
    Gut Signalling and Metabolism Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Cell 156:69-83. 2014
    ..distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets...
  90. ncbi Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms
    M Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Exp Gerontol 36:723-38. 2001
    ..proximally controlled by down regulation of juvenile hormone, a phenotype that is also produced by mutants of the insulin-like receptor InR, homologue of C. elegans daf-2. We propose neuroendocrine control of reproductive diapause in D...
  91. ncbi Axons guided by insulin receptor in Drosophila visual system
    Jianbo Song
    Brookdale Department for Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Science 300:502-5. 2003
    ..Here we show that the insulin receptor functions in axon guidance. The Drosophila insulin receptor (DInR) is required for photoreceptor-cell (R-cell) axons to find their way from the retina to the brain ..
  92. doi dFOXO regulates transcription of a Drosophila acid lipase
    Terhi Vihervaara
    Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00014 Helsinki, Finland
    J Mol Biol 376:1215-23. 2008
    b>Insulin resistance is a major feature of pathological states such as obesity and diabetes...
  93. doi A putative tyrosine phosphorylation site of the cell surface receptor Golden goal is involved in synaptic layer selection in the visual system
    Klaudiusz Mann
    Max Planck Institute of Neurobiology, Am Klopferspitz 18, Martinsried, Germany
    Development 139:760-71. 2012
    ..Drosophila Insulin-like receptor (DInR) has been reported to regulate the wiring of photoreceptors...
  94. ncbi Acquisition of insulin-dependent protein tyrosine kinase activity during Drosophila embryogenesis
    L Petruzzelli
    J Biol Chem 260:16072-5. 1985
    ..conclude that the insulin-binding and insulin-dependent protein tyrosine kinase activities of the mammalian insulin receptor are conserved in Drosophila...
  95. ncbi Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family
    A G Danielsen
    Department of Molecular Pharmacology, Stanford University School of Medicine, California 94305, USA
    J Biol Chem 270:21600-5. 1995
    ..and insulin-like growth factor-I receptors, the human insulin receptor-related receptor, and the Drosophila insulin receptor. Activation of overexpressed protein kinase C alpha resulted in a subsequent inhibition of the ligand-..
  96. ncbi Drosophila insulin receptor: lectin-binding properties and a role for oxidation-reduction of receptor thiols in activation
    M Marin-Hincapie
    Department of Anatomy and Cell Biology, State University of New York, Brooklyn 11203, USA
    Endocrinology 136:2357-66. 1995
    The glycosylation of the Drosophila insulin receptor (DIR) has been compared to that of the rat insulin receptor by examining the binding of receptors to the lectins wheat germ agglutinin, Concanavalin-A, and lentil lectin...
  97. ncbi Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase
    T C Yeh
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 271:2921-8. 1996
    ..chicken c-Src (mutant Phe-527) and in cells with the activated tyrosine kinase domains of the Drosophila insulin receptor, human insulin-like growth factor I receptor, and human insulin receptor-related receptor...
  98. ncbi Phosphoinositide 3-kinases: a conserved family of signal transducers
    B Vanhaesebroeck
    Ludwig Institute for Cancer Research, London, UK
    Trends Biochem Sci 22:267-72. 1997
    ..Potential signalling pathways downstream of PI3Ks have been elucidated and PI3K function is now being characterised in several model organisms...
  99. ncbi Intermittent divergence of the protein tyrosine kinase family during animal evolution
    H Suga
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    FEBS Lett 412:540-6. 1997
    ..These results strongly suggest that the PTKs diverged intermittently, but not gradually, during animal evolution...
  100. ncbi Longevity. Growing old together
    E Strauss
    Science 292:41-3. 2001
  101. pmc A new genetic locus controlling growth and proliferation in Drosophila melanogaster
    Sophie Raisin
    Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France
    Genetics 164:1015-25. 2003
    ..This suggested either that a particular combination of these transcripts was necessary or that other sequences are involved...

Research Grants8

  1. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2003
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..
  2. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2007
    ..In nematodes, mutation at the insulin/IGF pathway in a few cells is sufficient to slow aging. We found an analogous system in D...
  3. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2010
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  4. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2010
    ..Flies with ubiquitous, constitutive mutations at the insulin-like receptor (InR) and insulin receptor substrate (chico) retard demographic and functional aging, Recently, dFOXO of D...
  5. AGING AND NEURODEGENERATIVE DISEASES
    Cynthia Kenyon; Fiscal Year: 2006
    ....
  6. QUANTITATIVE TRAIT LOCI RELATED TO DROSOPHILA SPECIATION
    Sergey Nuzhdin; Fiscal Year: 2004
    ..This comprehensive assessment of the genetics of several traits will further our understanding of the genetics of speciation. ..
  7. Nucleotide polymorphisms responsible for expression variation in Drosophila
    Sergey Nuzhdin; Fiscal Year: 2009
    ..These studies will contribute to building a pathway-minded description of complex character variation. They will shed light on the genetic architecture of transcript level variation in nature. ..