Ilp5

Summary

Gene Symbol: Ilp5
Description: Insulin-like peptide 5
Alias: CG33273, DILP, DILP-5, DILP5, Dilp, Dilp 5, Dilp-5, Dilp5, Dmel\CG33273, ILP5, Ilp, Ilp-5, dILP-5, dILP5, dIlp5, dilp, dilp-5, dilp5, ilp5, CG33273 gene product from transcript CG33273-RA, CG33273-PA, Ilp5-PA, drosophila insulin-like peptide 5, insulin like peptide 5, insulin-like peptide, insulin-like peptide-5
Species: fruit fly

Top Publications

  1. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2009
  2. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
  3. pmc Altered modes of stem cell division drive adaptive intestinal growth
    Lucy Erin O'Brien
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 147:603-14. 2011
  4. pmc Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
    Susan Broughton
    UCL Institute of Healthy Ageing, GEE, University College London, London, UK
    PLoS ONE 3:e3721. 2008
  5. pmc dFOXO-independent effects of reduced insulin-like signaling in Drosophila
    Cathy Slack
    Institute of Healthy Ageing and GEE, University College London, Gower Street, London, UK
    Aging Cell 10:735-48. 2011
  6. pmc Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    Rita Sousa-Nunes
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 471:508-12. 2011
  7. pmc Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe
    Jishy Varghese
    Institute of Molecular and Cell Biology, Singapore 138673
    Genes Dev 24:2748-53. 2010
  8. pmc FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:813-25. 2010
  9. pmc JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila
    Jason Karpac
    Department of Biology, University of Rochester, River Campus Box 270211, Rochester, NY 14627, USA
    Aging Cell 8:288-95. 2009
  10. doi Remote control of insulin secretion by fat cells in Drosophila
    Charles Geminard
    Institute for Developmental Biology and Cancer, CNRS University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice, France
    Cell Metab 10:199-207. 2009

Research Grants

  1. QTL mapping age-related changes in lipid storage
    Maria De Luca; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications82

  1. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2009
    ..I discuss both the intracellular signalling network, as well as the communication between organs in the fly...
  2. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
    ..We propose that the input of neuronal clocks and clocks in metabolic tissues is coordinated to provide effective energy homeostasis...
  3. pmc Altered modes of stem cell division drive adaptive intestinal growth
    Lucy Erin O'Brien
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 147:603-14. 2011
    ..Thus, tissue renewal programs are not committed to maintain cellular equilibrium; stem cells can remodel organs in response to physiological triggers...
  4. pmc Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
    Susan Broughton
    UCL Institute of Healthy Ageing, GEE, University College London, London, UK
    PLoS ONE 3:e3721. 2008
    ..To understand the normal regulation of expression of the dilps and any functional diversification between them will require independent control of the expression of different dilps...
  5. pmc dFOXO-independent effects of reduced insulin-like signaling in Drosophila
    Cathy Slack
    Institute of Healthy Ageing and GEE, University College London, Gower Street, London, UK
    Aging Cell 10:735-48. 2011
    ....
  6. pmc Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    Rita Sousa-Nunes
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 471:508-12. 2011
    ..Drosophila thus contains two segregated ILP pools, one regulating proliferation within the central nervous system and the other controlling tissue growth ..
  7. pmc Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe
    Jishy Varghese
    Institute of Molecular and Cell Biology, Singapore 138673
    Genes Dev 24:2748-53. 2010
    ..Regulation of sugarbabe levels by nutrients and by miR-14 combines to allow the fly to manage resource mobilization in a nutritionally variable environment...
  8. pmc FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
    Fabio Demontis
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:813-25. 2010
    ..These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging...
  9. pmc JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila
    Jason Karpac
    Department of Biology, University of Rochester, River Campus Box 270211, Rochester, NY 14627, USA
    Aging Cell 8:288-95. 2009
    ..JNK activation in Insulin-producing cells (IPCs) is sufficient to repress Insulin and Insulin-like peptide (ILP) expression in rats and flies, but the significance of this interaction for adaptive responses to stress is unclear...
  10. doi Remote control of insulin secretion by fat cells in Drosophila
    Charles Geminard
    Institute for Developmental Biology and Cancer, CNRS University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice, France
    Cell Metab 10:199-207. 2009
    ..liver and white fat, couples the level of circulating Dilps with dietary amino acid levels by remotely controlling Dilp release through a TOR/RAPTOR-dependent mechanism...
  11. pmc Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities
    Hua Zhang
    Department of Entomology, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 106:19617-22. 2009
    ..In contrast, Df[dilp6] or Df[dilp7] animals showed no major metabolic defects. We discuss physiological differences between mammals and insects that may explain the unexpected survival of lean, 'diabetic' flies...
  12. doi Regulation of insulin-producing cells in the adult Drosophila brain via the tachykinin peptide receptor DTKR
    Ryan T Birse
    Department of Zoology, Stockholm University, Stockholm, Sweden
    J Exp Biol 214:4201-8. 2011
    ..Dilp2 and Dilp3, but not Dilp5, transcripts were significantly affected by DTKR knockdown in IPCs, both in fed and starved flies...
  13. pmc A Drosophila insulin-like peptide promotes growth during nonfeeding states
    Maija Slaidina
    Institute for Developmental Biology and Cancer, University of Nice Sophia Antipolis Centre National de la Recherche Scientifique, Parc Valrose, 06108 Nice, France
    Dev Cell 17:874-84. 2009
    ..We show here that, during metamorphosis, when feeding stops, a specific DILP (Dilp6) is produced by the fat body and relays the growth signal...
  14. pmc A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila
    Naoki Okamoto
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Dev Cell 17:885-91. 2009
    ..These data indicate that DILP6 is a functional, as well as a structural, counterpart of vertebrate IGFs. Our data provide in vivo evidence for a role of ILPs in determining adult body size through the regulation of postfeeding growth...
  15. pmc DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition
    Susan J Broughton
    Institute of Healthy Ageing and GEE, University College London, UK
    Aging Cell 9:336-46. 2010
    ..of an interaction between these mNSCs, nutrition and sleep, further emphasising the functional homology between the DILP-producing neurosecretory cells in the Drosophila brain and the hypothalamus of mammals in their roles as ..
  16. pmc Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan
    Yih Woei C Fridell
    Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA
    Aging (Albany NY) 1:699-713. 2009
    ..In summary, we have demonstrated a role for UCP in adult Drosophila IPCs in influencing systemic insulin signaling and longevity by a mechanism that may involve K(ATP) channels...
  17. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..sequences of 12 Drosophila species, and functional analysis, based on newly-generated knock-out mutations for all 7 dilp genes in D. melanogaster...
  18. pmc Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Aging Cell 10:137-47. 2011
    ..is capable of binding at least two of the seven Drosophila insulin-like peptides (DILPs), namely native DILP2 and DILP5 as present in the adult fly...
  19. pmc Structural and biological properties of the Drosophila insulin-like peptide 5 show evolutionary conservation
    Waseem Sajid
    Receptor Systems Biology Laboratory, Insulin and Incretin Biology, Hagedorn Research Institute, 2820 Gentofte, Denmark
    J Biol Chem 286:661-73. 2011
    We report the crystal structure of two variants of Drosophila melanogaster insulin-like peptide 5 (DILP5) at a resolution of 1.85 Å...
  20. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
    ....
  21. pmc Partial ablation of adult Drosophila insulin-producing neurons modulates glucose homeostasis and extends life span without insulin resistance
    Aaron Haselton
    Department of Biology, State University of New York at New Paltz, New Paltz, NY, USA
    Cell Cycle 9:3063-71. 2010
    ..set out to determine the impact of adult-specific partial ablation of IPCs (IPC knockdown) on insulin-like peptide (ILP) action, metabolic outcomes and longevity...
  22. pmc Blocking O-linked GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis
    Osamu Sekine
    Laboratory of Cell Biochemistry and Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:38684-91. 2010
    ..Knockdown of Ogt decreased Dilp2, Dilp3, and Dilp5 production, with reduced body size and decreased phosphorylation of Akt in vivo...
  23. pmc Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling
    Elizabeth J Rideout
    Department of Biochemistry and Molecular Biology, Clark H Smith Brain Tumour Centre, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 109:1139-44. 2012
    ..These findings suggest the stimulation of tRNA(i)(Met) synthesis via inhibition of dMaf1 is limiting for nutrition-dependent growth during development...
  24. pmc A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila
    Naoki Okamoto
    Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology, Chuo Ku, Hyogo, Japan
    Genes Dev 27:87-97. 2013
    ..We propose that Drosophila uses a secreted decoy to fine-tune systemic growth against fluctuations of circulating insulin levels...
  25. ncbi Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
    Tomoatsu Ikeya
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 12:1293-300. 2002
    ....
  26. ncbi Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
    Sean Oldham
    The Burnham Institute, La Jolla, CA 92037, USA
    Trends Cell Biol 13:79-85. 2003
    ..This review summarizes current studies primarily from Drosophila regarding the function of the insulin/IGF system in the control of growth...
  27. ncbi A nutrient sensor mechanism controls Drosophila growth
    Julien Colombani
    Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS Parc Valrose, 06108, Cedex 2, Nice, France
    Cell 114:739-49. 2003
    ..Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism...
  28. ncbi Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    Dae Sung Hwangbo
    Division of Biology and Medicine, Box G W, Brown University, Providence, Rhode Island 02912, USA
    Nature 429:562-6. 2004
    ..We further show that this limited activation of dFOXO reduces expression of the Drosophila insulin-like peptide dilp-2 synthesized in neurons, and represses endogenous insulin-dependent signalling in peripheral fat body...
  29. pmc Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion
    Akhila Rajan
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 151:123-37. 2012
    ..b>Dilp secretion in turn regulates energy balance and promotes systemic growth...
  30. pmc Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
    Susan J Broughton
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:3105-10. 2005
    ..However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation...
  31. ncbi Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005
    ..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
  32. pmc Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain
    Hua Bai
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Aging Cell 11:978-85. 2012
    ..Adult fat body dilp6 expression represses dilp2 and dilp5 mRNA in the brain, and the secretion of DILP2 into the hemolymph...
  33. ncbi Signaling and function of insulin-like peptides in insects
    Qi Wu
    Department of Cellular Biology, University of Georgia, Athens
    Annu Rev Entomol 51:1-24. 2006
    ..a) an integrated summary of the efforts to characterize the distribution of ILPs in insects and to define this pathway and its functions in Drosophila and (b) a few considerations for future studies of ILP endocrinology in insects.
  34. pmc Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila
    Lynne Marshall
    Department of Biochemistry and Molecular Biology, Clark H Smith Brain Tumour Centre, Southern Alberta Cancer Research Institute, University of Calgary, HRIC, Calgary, Alberta, Canada
    EMBO J 31:1916-30. 2012
    ..Thus, stimulation of Pol III is a key downstream effector of TOR in the control of cellular and systemic growth...
  35. ncbi Dynamics of the action of dFOXO on adult mortality in Drosophila
    Maria E Giannakou
    Centre for Research on Ageing, Department of Biology, University College London, London, UK
    Aging Cell 6:429-38. 2007
    ..The decreased mortality and increased lifespan of dFOXO overexpressing flies was uncoupled from any effect on female fecundity and from expression levels of Drosophila insulin-like peptides in the brain...
  36. pmc Drosophila lifespan control by dietary restriction independent of insulin-like signaling
    Kyung Jin Min
    Department of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Aging Cell 7:199-206. 2008
    ..In contrast, conditions of DR that increase lifespan change only insulin-like peptide-5 (ilp5) mRNA abundance...
  37. doi Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
    Kyu Sun Lee
    Centre for Regenerative Medicine, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon 305 333, Korea
    Nat Cell Biol 10:468-75. 2008
    ..Drosophila sNPF and the evolutionarily conserved mammalian NPY seem to regulate ERK-mediated insulin expression and thus to systemically modulate growth, metabolism and lifespan...
  38. doi Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling
    Susanne Buch
    Institute of Genetics, Forschungszentrum Karlsruhe, 76021 Karlsruhe, Germany
    Cell Metab 7:321-32. 2008
    ..tobi is thus a target of the insulin- and glucagon-like signaling system that responds oppositely to dietary protein and sugar...
  39. doi Drosophila ALS regulates growth and metabolism through functional interaction with insulin-like peptides
    Nathalie Arquier
    Universite de Nice Sophia Antipolis, IBDC, CNRS UMR 6543, Parc Valrose, 06108 Nice Cedex 2, France
    Cell Metab 7:333-8. 2008
    ..In Drosophila, a family of seven insulin-like peptides, called Dilps, activate a common insulin receptor. Some Dilp peptides carry both metabolic and growth functions, raising the possibility that various binding partners specify ..
  40. pmc Drosophila germ-line modulation of insulin signaling and lifespan
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 105:6368-73. 2008
    ..These results suggest that signals from the gonad regulate lifespan and modulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved...
  41. pmc The Drosophila ARC homolog regulates behavioral responses to starvation
    Mark D Mattaliano
    Department of Biology and National Center for Behavior Genomics, Brandeis University, Waltham, MA 02454 9110, USA
    Mol Cell Neurosci 36:211-21. 2007
    ..This suggests that there are multiple modes of communication between the pars and the ring gland that control starvation-induced behavioral responses...
  42. ncbi Freeze-dried royal jelly maintains its developmental and physiological bioactivity in Drosophila melanogaster
    Yasunari Kayashima
    School of Food and Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizouka 422 8526, Japan
    Biosci Biotechnol Biochem 76:2107-11. 2012
    ..Moreover, the expression of dilp5, an insulin-like peptide, its receptor InR, and the nutrient sensing molecule TOR, the target of rapamycin, was ..
  43. pmc A genetic strategy to measure circulating Drosophila insulin reveals genes regulating insulin production and secretion
    Sangbin Park
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 10:e1004555. 2014
    ..Discovery of Drosophila mechanisms and regulators controlling in vivo insulin dynamics should accelerate functional dissection of diabetes genetics. ..
  44. pmc Drosophila adiponectin receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion
    Su Jin Kwak
    Neurophysiology Research Group, Bionano Centre, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, Korea
    PLoS ONE 8:e68641. 2013
    ..This study demonstrates a new adipokine signaling in Drosophila and provides insights for the mammalian adiponectin receptor function in pancreatic beta cells, which could be useful for therapeutic application. ..
  45. pmc Nutritional Geometric Profiles of Insulin/IGF Expression in Drosophila melanogaster
    Stephanie Post
    Department of Molecular Biology, Cell Biology and Biochemistry, Providence, RI, Brown University, United States of America
    PLoS ONE 11:e0155628. 2016
    ..b>Dilp5 expression was highly expressed at approximately a 1:2 protein-to-carbohydrate ratio and its level increased with ..
  46. pmc The sleeping beauty: how reproductive diapause affects hormone signaling, metabolism, immune response and somatic maintenance in Drosophila melanogaster
    Olga I Kubrak
    Department of Zoology, Stockholm University, S 106 91 Stockholm, Sweden
    PLoS ONE 9:e113051. 2014
    ..Furthermore, mutant flies lacking specific insulin-like peptides (dilp5 and dilp2-3) display increased diapause incidence...
  47. pmc The song of the old mother: reproductive senescence in female drosophila
    Paige B Miller
    a Department of Biology Gustavus Adolphus College St Peter, MN USA
    Fly (Austin) 8:127-39. 2014
    ..Understanding the genetic basis of reproductive senescence clarifies the nature of life-history trade-offs as well as potential ways to augment and/or limit female fertility in a variety of organisms. ..
  48. doi Ecdysone and insulin signaling play essential roles in readjusting the altered body size caused by the dGPAT4 mutation in Drosophila
    Yan Yan
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100080, China
    J Genet Genomics 42:487-94. 2015
    ..Thus, we propose that a strategy has been evolved by the animals to reach final body size when challenged by genetic alterations, which requires the coordinated ecdysone and insulin signaling. ..
  49. pmc Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila
    Patrick Fischer
    Institute of Genetics, University of Hohenheim, Stuttgart, Germany
    PLoS Genet 11:e1005440. 2015
    ..Together, our data suggest that CycG acts at the level of Akt1 to regulate growth and metabolism via PP2A in Drosophila. ..
  50. pmc Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet
    Katie J Woodcock
    Immunity 42:133-44. 2015
    ....
  51. doi The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin Signaling
    Michael J Williams
    Department of Neuroscience, Division of Functional Pharmacology, Uppsala University, 75 124 Uppsala, Sweden
    Mol Endocrinol 29:1303-19. 2015
    ..These results point toward a role for this gene in the regulation of insulin signaling, which could explain the robust association with obesity in humans. ..
  52. pmc The drosophila T-box transcription factor midline functions within Insulin/Akt and c-Jun-N terminal kinase stress-reactive signaling pathways to regulate interommatial bristle formation and cell survival
    Q Brent Chen
    The Department of Biological Sciences, USM, USA
    Mech Dev 136:8-29. 2015
    ....
  53. doi Food odors trigger an endocrine response that affects food ingestion and metabolism
    Oleh V Lushchak
    Department of Zoology, Stockholm University, 10691, Stockholm, Sweden
    Cell Mol Life Sci 72:3143-55. 2015
    ..Thus, we show that food odor can induce a transient anticipatory endocrine response, and that boosted sensitivity to this odor affects food intake, as well as metabolism and hormonal signaling. ..
  54. pmc Neuronal control of metabolism through nutrient-dependent modulation of tracheal branching
    Gerit A Linneweber
    Gut Signalling and Metabolism Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Cell 156:69-83. 2014
    ..Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture...
  55. pmc Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals
    Seung Hyun Hong
    Aging Research Centre, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    PLoS Genet 8:e1002857. 2012
    ..Our findings demonstrate that Mnb/Dyrk1a regulates food intake through the evolutionary conserved Sir2-FOXO-sNPF/NPY pathway in Drosophila melanogaster and mammals...
  56. doi PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation
    Katrin Hahn
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Cell Metab 11:438-44. 2010
    ..Since S6K affects development of cancer and metabolic disease, our data identify PPP2R5C as a novel factor of potential medical relevance...
  57. pmc A reverse genetic screen in Drosophila using a deletion-inducing mutagen
    Knud Nairz
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, Zurich CH 8057, Switzerland
    Genome Biol 5:R83. 2004
    ..As the spectrum of HMPA-induced mutations is similar in a variety of organisms, it should be possible to transfer this mutagenesis and detection procedure to other model systems...
  58. pmc Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster
    Yue Yu
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Mol Cell Biol 32:3610-23. 2012
    ..dCbl deficiency in either the brain or insulin-producing cells upregulated the expression of dilp genes, resulting in elevated activation of the dILP pathway, including phosphorylation of Drosophila Akt and ..
  59. pmc Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression
    Naoki Okamoto
    Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology, Chuo ku Kobe, Hyogo 650 0047, Japan
    Proc Natl Acad Sci U S A 109:2406-11. 2012
    ..genome encodes seven insulin-like peptide genes, dilp1-7, and the most prominent dilps (dilp2, dilp3, and dilp5) are expressed in brain neurosecretory cells known as "insulin-producing cells" (IPCs)...
  60. doi A putative tyrosine phosphorylation site of the cell surface receptor Golden goal is involved in synaptic layer selection in the visual system
    Klaudiusz Mann
    Max Planck Institute of Neurobiology, Am Klopferspitz 18, Martinsried, Germany
    Development 139:760-71. 2012
    ..We propose the model that a constant phosphorylation signal is antagonized by a presumably temporal dephosphorylation signal, which creates a permissive signal that controls developmental timing in axon targeting...
  61. pmc The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila
    Biao Wang
    Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA
    Cell Metab 7:434-44. 2008
    ..As disruption of insulin signaling also augmented TORC activity in adult flies, our results illustrate the importance of an insulin-regulated pathway that functions in the brain to maintain energy balance...
  62. doi Oocyte destruction is activated during viral infection
    Travis C Thomson
    Department of Obstetrics, Gynecology, and Reproductive Sciences Division of Reproductive Endocrinology and Infertility, Yale School of Medicine, New Haven, Connecticut, USA
    Genesis 50:453-65. 2012
    ..The genetic and signaling requirements for oocyte destruction delineated here represent a novel host-virus interaction with implications for the control of both fly and virus populations...
  63. doi Drosophila ia2 modulates secretion of insulin-like peptide
    Jihyun Kim
    Department of Molecular Biology, Sejong University, 98 Kunja dong, Kwangjin ku 143 747, Seoul, South Korea
    Comp Biochem Physiol A Mol Integr Physiol 151:180-4. 2008
    ..As the pancreas develops from the gut during vertebrate development, our results suggest a possible role of IA-2 in insulin and hexokinase regulation...
  64. doi Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling
    Seung Chul Shin
    School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151 742, South Korea
    Science 334:670-4. 2011
    ..Importantly, these defects were reversed by enhancing host IIS or by supplementing the diet with acetic acid, the metabolic product of PQQ-ADH...
  65. pmc SLOB, a SLOWPOKE channel binding protein, regulates insulin pathway signaling and metabolism in Drosophila
    Amanda L Sheldon
    Department of Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e23343. 2011
    ..We propose that modulation of SLO by SLOB regulates neurotransmission in mNSCs, influencing downstream insulin pathway signaling and metabolism...
  66. pmc Regulation of adult stem cell behavior by nutrient signaling
    Lei Wang
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA
    Cell Cycle 10:2628-34. 2011
    ..Here we discuss our data regarding the effects and mechanisms by which changes in systemic nutritional conditions may influence the maintenance and activity of adult stem cells via insulin signaling...
  67. pmc Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance
    Jeannette A E Söderberg
    Department of Zoology, Stockholm University, Stockholm, Sweden
    PLoS ONE 6:e19866. 2011
    ..Here we show that DILP5 is expressed in principal cells of the renal tubules of Drosophila and affects survival at stress...
  68. pmc A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway
    Kimberly D McClure
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA
    Dis Model Mech 4:335-46. 2011
    ..due to the effects of ethanol on insulin signaling; specifically, a reduction in Drosophila insulin-like peptide (Dilp) and insulin receptor expression...
  69. doi Molecular evolution of the ligands of the insulin-signaling pathway: dilp genes in the genus Drosophila
    Sara Guirao-Rico
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Mol Biol Evol 28:1557-60. 2011
    ....
  70. pmc SH2B regulation of growth, metabolism, and longevity in both insects and mammals
    Wei Song
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Metab 11:427-37. 2010
    ..These data suggest that dSH2B regulation of insulin-like signaling, growth, and metabolism is conserved in SH2B1, whereas dSH2B regulation of oxidative stress and longevity may be conserved in other SH2B family members...
  71. pmc Insulin signalling regulates remating in female Drosophila
    Stuart Wigby
    Institute of Healthy Ageing and, Department of Genetics, Evolution and Environment, University College London, UK
    Proc Biol Sci 278:424-31. 2011
    ..of Drosophila insulin-like peptide (DILP)-producing median neurosecretory cells, knockout of dilp2, dilp3 or dilp5 genes, expression of a dominant-negative DILP-receptor (InR) transgene or knockout of Lnk, results in reduced ..
  72. pmc A conserved role for syndecan family members in the regulation of whole-body energy metabolism
    Maria De Luca
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e11286. 2010
    ..035) and intra-abdominal fat (P = 0.049), and SNP rs2267871 with insulin sensitivity (P = 0.037). Collectively, our results in Drosophila and humans argue that syndecan family members play a key role in the regulation of body metabolism...
  73. pmc Long-lived Indy and calorie restriction interact to extend life span
    Pei yu Wang
    Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 106:9262-7. 2009
    ..We conclude that Indy and CR interact to affect longevity and that a decrease in Indy may induce a CR-like status that confers life span extension...
  74. pmc Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz
    Julie Hull-Thompson
    Department of Biology, University of Rochester, Rochester, New York, United States of America
    PLoS Genet 5:e1000460. 2009
    ..The JNK pathway and Lipocalins are structurally and functionally conserved, suggesting that similar interactions represent an evolutionarily conserved system for the control of metabolic homeostasis...
  75. pmc Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan
    Dickon M Humphrey
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Exp Gerontol 44:316-27. 2009
    ..Expression of hUCP3 in the mNSC did not alter expression of dilp2, dilp3 or dilp5 mRNA, but led to increased amounts of DILP2 in fly heads...
  76. pmc Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons
    Jason Clements
    Laboratory of Developmental Genetics, VIB, and Center of Human Genetics, Katholieke Universiteit Leuven, Herestraat 49, Box 602, B 3000, Leuven, Belgium
    Proc Natl Acad Sci U S A 105:16183-8. 2008
    ..demonstrate that Eyeless controls IPC function by the direct transcriptional control of one of the major Dilps, dilp5. We propose that Eyeless has an evolutionarily conserved role in IPCs with remarkable similarities to the role of ..
  77. pmc Drosophila lacking microRNA miR-278 are defective in energy homeostasis
    Aurelio A Teleman
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 20:417-22. 2006
    ..We provide evidence that miR-278 mutants are insulin resistant and that miR-278 acts through regulation of the expanded transcript...
  78. ncbi Body-size regulation: combining genetics and physiology
    Alexander W Shingleton
    Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA
    Curr Biol 15:R825-7. 2005
    ..New research has revealed that the activity of the insulin-signaling pathway in the prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duration and rate of larval growth...
  79. ncbi Amino acids and the humoral regulation of growth: fat bodies use slimfast
    Gemma L Bradley
    BioMed Central, Middlesex House, 34 42 Cleveland Street, W1T 4LB, London, United Kingdom
    Cell 114:656-8. 2003
    ..In this issue of Cell, Colombani et al. demonstrate that amino acid-responsive TOR signaling in the Drosophila fat body modulates insulin signaling and growth in peripheral tissues...
  80. ncbi Insulin-related peptides and their conserved signal transduction pathway
    Ilse Claeys
    Laboratory for Developmental Physiology and Molecular Biology, K U, Leuven, Belgium
    Peptides 23:807-16. 2002
    ....
  81. ncbi Growth control: invertebrate insulin surprises!
    S J Leevers
    Ludwig Institute for Cancer Research, 91 Riding House Street, W1W 7BS, London, UK
    Curr Biol 11:R209-12. 2001
    ..Invertebrates have been found to possess more insulin-like ligands than predicted, some of which behave as receptor antagonists...

Research Grants1

  1. QTL mapping age-related changes in lipid storage
    Maria De Luca; Fiscal Year: 2007
    ..Moreover, knowledge of the nature and frequency of causative genetic polymorphisms will lead to a better understanding of the mechanisms that maintain genetic variation in these traits in natural populations. ..