Genomes and Genes
Gene Symbol: Ilp1
Description: Insulin-like peptide 1
Alias: CG14173, DILP, DILP-1, DILP1, Dilp, Dilp 1, Dilp-1, Dilp1, Dmel\CG14173, Ilp, Ilp-1, dILP1, dilp, dilp-1, dilp1, ilp1, CG14173 gene product from transcript CG14173-RA, CG14173-PA, Ilp1-PA, drosophila insulin-like peptide 1, insulin-like peptide
Species: fruit fly
- Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in DrosophilaRita Sousa-Nunes
Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Nature 471:508-12. 2011..Drosophila thus contains two segregated ILP pools, one regulating proliferation within the central nervous system and the other controlling tissue growth ..
- Molecular evolution and functional characterization of Drosophila insulin-like peptidesSebastian Gronke
Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
PLoS Genet 6:e1000857. 2010..sequences of 12 Drosophila species, and functional analysis, based on newly-generated knock-out mutations for all 7 dilp genes in D. melanogaster...
- Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in DrosophilaTomoatsu Ikeya
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Curr Biol 12:1293-300. 2002....
- Insulin/IGF and target of rapamycin signaling: a TOR de force in growth controlSean Oldham
The Burnham Institute, La Jolla, CA 92037, USA
Trends Cell Biol 13:79-85. 2003..This review summarizes current studies primarily from Drosophila regarding the function of the insulin/IGF system in the control of growth...
- A fat body-derived IGF-like peptide regulates postfeeding growth in DrosophilaNaoki Okamoto
Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
Dev Cell 17:885-91. 2009..These data indicate that DILP6 is a functional, as well as a structural, counterpart of vertebrate IGFs. Our data provide in vivo evidence for a role of ILPs in determining adult body size through the regulation of postfeeding growth...
- Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat bodyDae Sung Hwangbo
Division of Biology and Medicine, Box G W, Brown University, Providence, Rhode Island 02912, USA
Nature 429:562-6. 2004..We further show that this limited activation of dFOXO reduces expression of the Drosophila insulin-like peptide dilp-2 synthesized in neurons, and represses endogenous insulin-dependent signalling in peripheral fat body...
- Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in DrosophilaQi Wu
Department of Cellular Biology, and Biomedical and Health Sciences Institute, University of Georgia, 724 Biological Sciences Building, Athens, GA 30602, USA
Proc Natl Acad Sci U S A 102:13289-94. 2005..g., a less accessible solid food). Moreover, up-regulation of Drosophila p70/S6 kinase activity in DILP neurons led to attenuated hunger response by fasted larvae, whereas its down-regulation triggered fed larvae to ..
- A Drosophila insulin-like peptide promotes growth during nonfeeding statesMaija Slaidina
Institute for Developmental Biology and Cancer, University of Nice Sophia Antipolis Centre National de la Recherche Scientifique, Parc Valrose, 06108 Nice, France
Dev Cell 17:874-84. 2009..We show here that, during metamorphosis, when feeding stops, a specific DILP (Dilp6) is produced by the fat body and relays the growth signal...
- Molecular mechanisms of metabolic regulation by insulin in DrosophilaAurelio A Teleman
German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Biochem J 425:13-26. 2009..I discuss both the intracellular signalling network, as well as the communication between organs in the fly...
- Signaling and function of insulin-like peptides in insectsQi Wu
Department of Cellular Biology, University of Georgia, Athens
Annu Rev Entomol 51:1-24. 2006..a) an integrated summary of the efforts to characterize the distribution of ILPs in insects and to define this pathway and its functions in Drosophila and (b) a few considerations for future studies of ILP endocrinology in insects.
- Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalitiesHua Zhang
Department of Entomology, University of Maryland, College Park, MD 20742, USA
Proc Natl Acad Sci U S A 106:19617-22. 2009..Furthermore, circulating sugar levels are elevated in Df [dilp1-5] homozygotes during eating and fasting...
- Obesity-blocking neurons in DrosophilaBader Al-Anzi
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Neuron 63:329-41. 2009..Our results show that the fly brain measures fat store levels and can induce changes in food intake and metabolism to maintain them within normal limits...
- Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signallingKyu Sun Lee
Centre for Regenerative Medicine, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon 305 333, Korea
Nat Cell Biol 10:468-75. 2008..Drosophila sNPF and the evolutionarily conserved mammalian NPY seem to regulate ERK-mediated insulin expression and thus to systemically modulate growth, metabolism and lifespan...
- An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth controlW Brogiolo
Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
Curr Biol 11:213-21. 2001....
- A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in DrosophilaNaoki Okamoto
Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology, Chuo Ku, Hyogo, Japan
Genes Dev 27:87-97. 2013..We propose that Drosophila uses a secreted decoy to fine-tune systemic growth against fluctuations of circulating insulin levels...
- Long-range targeted manipulation of the Drosophila genome by site-specific integration and recombinational resolutionNatalia Wesolowska
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Genetics 193:411-9. 2013..Excitingly, all of the components involved are likely functional in other eukaryotes, making our scheme for long-range targeted manipulation readily applicable to other systems...
- Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brainHua Bai
Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
Aging Cell 11:978-85. 2012..in diverse species, including Drosophila melanogaster where the genome encodes seven insulin-like peptides (dilp1-7)...
- Patterns of nucleotide diversity at the regions encompassing the Drosophila insulin-like peptide (dilp) genes: demography vs. positive selection in Drosophila melanogasterSara Guirao-Rico
Departament de Genetica, i Institut de Recerca de la Biodiversitat, Universitat de Barcelona, Barcelona, Spain
PLoS ONE 8:e53593. 2013..With this aim, we have surveyed nucleotide sequence variation at the dilp1-7 genes in a natural population of D. melanogaster. The comparison of polymorphism in D...
- Of flies and men: insights on organismal metabolism from fruit fliesAkhila Rajan
Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
BMC Biol 11:38. 2013....
- Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signalingIvan Ostojic
Growth Control Unit, Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
Proc Natl Acad Sci U S A 111:8143-8. 2014..Together our data suggest that different gustatory cues can modulate the activities of distinct signaling pathways, including different insulin-like peptides, to promote physiological changes that ultimately affect lifespan. ..
- Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3Jung Kim
Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, Minnesota 55455, USA
Nat Commun 6:6846. 2015..Thus, IPCs integrate multiple cues to regulate the secretion of distinct insulin subtypes under varying nutrient conditions. ..
- Cell mixing induced by myc is required for competitive tissue invasion and destructionRomain Levayer
Institute for Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland
Nature 524:476-80. 2015..Our results establish the first link between cell-cell intercalation induced by a proto-oncogene and how it promotes invasiveness and destruction of healthy tissues. ..
- Nutritional Geometric Profiles of Insulin/IGF Expression in Drosophila melanogasterStephanie Post
Department of Molecular Biology, Cell Biology and Biochemistry, Providence, RI, Brown University, United States of America
PLoS ONE 11:e0155628. 2016..To understand how dietary protein and sugar affect dilp expression, we followed the analytical concepts of the Nutritional Geometric Framework, feeding Drosophila adults ..
- Drosophila insulin-like peptide 1 (DILP1) is transiently expressed during non-feeding stages and reproductive dormancyYiting Liu
Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
Sci Rep 6:26620. 2016..In Drosophila, eight insulin-like peptides (DILP1-8) are known, six of which have been investigated in some detail, whereas expression and functions of DILP1 and ..
- Drosophila ia2 modulates secretion of insulin-like peptideJihyun Kim
Department of Molecular Biology, Sejong University, 98 Kunja dong, Kwangjin ku 143 747, Seoul, South Korea
Comp Biochem Physiol A Mol Integr Physiol 151:180-4. 2008..As the pancreas develops from the gut during vertebrate development, our results suggest a possible role of IA-2 in insulin and hexokinase regulation...
- The Drosophila retained/dead ringer gene and ARID gene family function during developmentTetyana Shandala
Centre for the Molecular Genetics of Development and Dept of Molecular Biosciences, Adelaide University, SA, Australia
Int J Dev Biol 46:423-30. 2002..Finally, we have used germline clone analysis to reveal a requirement for retn/dri in the Drosophila preblastoderm syncytial mitoses...
- Molecular evolution of the ligands of the insulin-signaling pathway: dilp genes in the genus DrosophilaSara Guirao-Rico
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Mol Biol Evol 28:1557-60. 2011Drosophila melanogaster, unlike mammals, has seven insulin-like peptides (DILPS). In Drosophila, all seven genes (dilp1-7) are single copy in the 12 species studied, except for D. grimshawi with two tandem copies of dilp2...
- Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogasterKyu Sun Lee
Aging Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, Republic of Korea
FEBS Lett 583:2573-7. 2009..These results indicate that sNPF1 and sNPF2 peptides processed from the sNPF precursor are sufficient for regulating body growth through the ERK-insulin pathway in Drosophila...
- Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespanDickon M Humphrey
MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
Exp Gerontol 44:316-27. 2009..These data suggest that lowering mitochondrial coupling by high expression of hUCP3 alters mNSC function in a way that appears to increase DILP-levels in fly heads and lead to a concomitant decrease in lifespan.
- Dynamics of the action of dFOXO on adult mortality in DrosophilaMaria E Giannakou
Centre for Research on Ageing, Department of Biology, University College London, London, UK
Aging Cell 6:429-38. 2007..The decreased mortality and increased lifespan of dFOXO overexpressing flies was uncoupled from any effect on female fecundity and from expression levels of Drosophila insulin-like peptides in the brain...
- Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brainBegona De Velasco
Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
Dev Biol 302:309-23. 2007..NSCs labeled by the expression of Drosophila insulin-like peptide (Dilp), FMRF, and myomodulin form part of the Dchx1 expressing PI domain...
- Body-size regulation: combining genetics and physiologyAlexander W Shingleton
Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA
Curr Biol 15:R825-7. 2005..New research has revealed that the activity of the insulin-signaling pathway in the prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duration and rate of larval growth...
- Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life historyThomas Flatt
Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
Bioessays 27:999-1010. 2005..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
- Amino acids and the humoral regulation of growth: fat bodies use slimfastGemma L Bradley
BioMed Central, Middlesex House, 34 42 Cleveland Street, W1T 4LB, London, United Kingdom
Cell 114:656-8. 2003..In this issue of Cell, Colombani et al. demonstrate that amino acid-responsive TOR signaling in the Drosophila fat body modulates insulin signaling and growth in peripheral tissues...
- Insulin-related peptides and their conserved signal transduction pathwayIlse Claeys
Laboratory for Developmental Physiology and Molecular Biology, K U, Leuven, Belgium
Peptides 23:807-16. 2002....
- Growth control: invertebrate insulin surprises!S J Leevers
Ludwig Institute for Cancer Research, 91 Riding House Street, W1W 7BS, London, UK
Curr Biol 11:R209-12. 2001..Invertebrates have been found to possess more insulin-like ligands than predicted, some of which behave as receptor antagonists...