Ilp1

Summary

Gene Symbol: Ilp1
Description: Insulin-like peptide 1
Alias: CG14173, DILP, DILP-1, DILP1, Dilp, Dilp 1, Dilp-1, Dilp1, Dmel\CG14173, Ilp, Ilp-1, dILP1, dilp, dilp-1, dilp1, ilp1, CG14173 gene product from transcript CG14173-RA, CG14173-PA, Ilp1-PA, drosophila insulin-like peptide 1, insulin-like peptide
Species: fruit fly

Top Publications

  1. pmc Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    Rita Sousa-Nunes
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 471:508-12. 2011
  2. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
  3. ncbi Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
    Tomoatsu Ikeya
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 12:1293-300. 2002
  4. ncbi Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
    Sean Oldham
    The Burnham Institute, La Jolla, CA 92037, USA
    Trends Cell Biol 13:79-85. 2003
  5. pmc A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila
    Naoki Okamoto
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Dev Cell 17:885-91. 2009
  6. ncbi Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    Dae Sung Hwangbo
    Division of Biology and Medicine, Box G W, Brown University, Providence, Rhode Island 02912, USA
    Nature 429:562-6. 2004
  7. pmc Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila
    Qi Wu
    Department of Cellular Biology, and Biomedical and Health Sciences Institute, University of Georgia, 724 Biological Sciences Building, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 102:13289-94. 2005
  8. pmc A Drosophila insulin-like peptide promotes growth during nonfeeding states
    Maija Slaidina
    Institute for Developmental Biology and Cancer, University of Nice Sophia Antipolis Centre National de la Recherche Scientifique, Parc Valrose, 06108 Nice, France
    Dev Cell 17:874-84. 2009
  9. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2009
  10. ncbi Signaling and function of insulin-like peptides in insects
    Qi Wu
    Department of Cellular Biology, University of Georgia, Athens
    Annu Rev Entomol 51:1-24. 2006

Scientific Experts

  • Qi Wu
  • Akhila Rajan
  • Aurelio A Teleman
  • S J Leevers
  • Ilse Claeys
  • Alexander W Shingleton
  • Thomas Flatt
  • Bader Al-Anzi
  • Dickon M Humphrey
  • Sara Guirao-Rico
  • Naoki Okamoto
  • Marc Tatar
  • Kyu Sun Lee
  • Sebastian Gronke
  • Linda Partridge
  • Stephanie Post
  • Yiting Liu
  • Jung Kim
  • Romain Levayer
  • Ivan Ostojic
  • Natalia Wesolowska
  • Montserrat Aguade
  • Hua Bai
  • Rita Sousa-Nunes
  • Hua Zhang
  • Maija Slaidina
  • Kweon Yu
  • O Yu Kwon
  • Ae Kyeong Kim
  • Jihyun Kim
  • Maria E Giannakou
  • Begona De Velasco
  • Dae Sung Hwangbo
  • Dick R Nassel
  • Sean Oldham
  • Jan A Veenstra
  • Gemma L Bradley
  • Sifang Liao
  • Thomas P Neufeld
  • Eduardo Moreno
  • Ernst Hafen
  • Barbara Hauert
  • Rashmi Chandra
  • Tetyana Shandala
  • Werner Boll
  • Michael J Waterson
  • Tomoatsu Ikeya
  • Joy Alcedo
  • Tammy Chan
  • Scott D Pletcher
  • Aya Masuda
  • Tomoka Murai
  • Rinna Nakamori
  • Takashi Nishimura
  • Yuki Yamauchi
  • Yikang S Rong
  • Ping Kang
  • W Brogiolo
  • Lih Ling Yee
  • Alex P Gould
  • Susan Broughton
  • T Daniel Andrews
  • David Francis Clarke
  • Leslie Pick
  • Jingnan Liu
  • Hiroshi Kataoka
  • Bahram Momen
  • Caroline R Li
  • Yoshimasa Yagi
  • Naoki Yamanaka
  • Renald Delanoue
  • Sung Kyu Ju
  • Ronald A Kohanski
  • Seung Hyun Hong
  • Pierre Leopold
  • Akira Mizoguchi
  • MICHAEL B O'CONNOR
  • Yasuyoshi Nishida
  • Inhee Jung
  • Syungkyun Ko
  • Sun Ah Jung
  • Jeongsil Kim-Ha
  • Hyojoo Bang
  • Kwan Hee You
  • Kyung Jin Min
  • Joon H Lee
  • Haehee Hong
  • Kisang Kwon
  • Martin Goss
  • Roderick McInnes

Detail Information

Publications37

  1. pmc Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    Rita Sousa-Nunes
    Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 471:508-12. 2011
    ..Drosophila thus contains two segregated ILP pools, one regulating proliferation within the central nervous system and the other controlling tissue growth ..
  2. pmc Molecular evolution and functional characterization of Drosophila insulin-like peptides
    Sebastian Gronke
    Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, London, United Kingdom
    PLoS Genet 6:e1000857. 2010
    ..sequences of 12 Drosophila species, and functional analysis, based on newly-generated knock-out mutations for all 7 dilp genes in D. melanogaster...
  3. ncbi Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
    Tomoatsu Ikeya
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 12:1293-300. 2002
    ....
  4. ncbi Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
    Sean Oldham
    The Burnham Institute, La Jolla, CA 92037, USA
    Trends Cell Biol 13:79-85. 2003
    ..This review summarizes current studies primarily from Drosophila regarding the function of the insulin/IGF system in the control of growth...
  5. pmc A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila
    Naoki Okamoto
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Dev Cell 17:885-91. 2009
    ..These data indicate that DILP6 is a functional, as well as a structural, counterpart of vertebrate IGFs. Our data provide in vivo evidence for a role of ILPs in determining adult body size through the regulation of postfeeding growth...
  6. ncbi Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    Dae Sung Hwangbo
    Division of Biology and Medicine, Box G W, Brown University, Providence, Rhode Island 02912, USA
    Nature 429:562-6. 2004
    ..We further show that this limited activation of dFOXO reduces expression of the Drosophila insulin-like peptide dilp-2 synthesized in neurons, and represses endogenous insulin-dependent signalling in peripheral fat body...
  7. pmc Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila
    Qi Wu
    Department of Cellular Biology, and Biomedical and Health Sciences Institute, University of Georgia, 724 Biological Sciences Building, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 102:13289-94. 2005
    ..g., a less accessible solid food). Moreover, up-regulation of Drosophila p70/S6 kinase activity in DILP neurons led to attenuated hunger response by fasted larvae, whereas its down-regulation triggered fed larvae to ..
  8. pmc A Drosophila insulin-like peptide promotes growth during nonfeeding states
    Maija Slaidina
    Institute for Developmental Biology and Cancer, University of Nice Sophia Antipolis Centre National de la Recherche Scientifique, Parc Valrose, 06108 Nice, France
    Dev Cell 17:874-84. 2009
    ..We show here that, during metamorphosis, when feeding stops, a specific DILP (Dilp6) is produced by the fat body and relays the growth signal...
  9. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2009
    ..I discuss both the intracellular signalling network, as well as the communication between organs in the fly...
  10. ncbi Signaling and function of insulin-like peptides in insects
    Qi Wu
    Department of Cellular Biology, University of Georgia, Athens
    Annu Rev Entomol 51:1-24. 2006
    ..a) an integrated summary of the efforts to characterize the distribution of ILPs in insects and to define this pathway and its functions in Drosophila and (b) a few considerations for future studies of ILP endocrinology in insects.
  11. pmc Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities
    Hua Zhang
    Department of Entomology, University of Maryland, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 106:19617-22. 2009
    ..Furthermore, circulating sugar levels are elevated in Df [dilp1-5] homozygotes during eating and fasting...
  12. pmc Obesity-blocking neurons in Drosophila
    Bader Al-Anzi
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 63:329-41. 2009
    ..Our results show that the fly brain measures fat store levels and can induce changes in food intake and metabolism to maintain them within normal limits...
  13. doi Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
    Kyu Sun Lee
    Centre for Regenerative Medicine, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon 305 333, Korea
    Nat Cell Biol 10:468-75. 2008
    ..Drosophila sNPF and the evolutionarily conserved mammalian NPY seem to regulate ERK-mediated insulin expression and thus to systemically modulate growth, metabolism and lifespan...
  14. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
    ....
  15. pmc A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila
    Naoki Okamoto
    Laboratory for Growth Control Signaling, RIKEN Center for Developmental Biology, Chuo Ku, Hyogo, Japan
    Genes Dev 27:87-97. 2013
    ..We propose that Drosophila uses a secreted decoy to fine-tune systemic growth against fluctuations of circulating insulin levels...
  16. pmc Long-range targeted manipulation of the Drosophila genome by site-specific integration and recombinational resolution
    Natalia Wesolowska
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Genetics 193:411-9. 2013
    ..Excitingly, all of the components involved are likely functional in other eukaryotes, making our scheme for long-range targeted manipulation readily applicable to other systems...
  17. pmc Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain
    Hua Bai
    Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Aging Cell 11:978-85. 2012
    ..in diverse species, including Drosophila melanogaster where the genome encodes seven insulin-like peptides (dilp1-7)...
  18. pmc Patterns of nucleotide diversity at the regions encompassing the Drosophila insulin-like peptide (dilp) genes: demography vs. positive selection in Drosophila melanogaster
    Sara Guirao-Rico
    Departament de Genetica, i Institut de Recerca de la Biodiversitat, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e53593. 2013
    ..With this aim, we have surveyed nucleotide sequence variation at the dilp1-7 genes in a natural population of D. melanogaster. The comparison of polymorphism in D...
  19. pmc Of flies and men: insights on organismal metabolism from fruit flies
    Akhila Rajan
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    BMC Biol 11:38. 2013
    ....
  20. pmc Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling
    Ivan Ostojic
    Growth Control Unit, Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
    Proc Natl Acad Sci U S A 111:8143-8. 2014
    ..Together our data suggest that different gustatory cues can modulate the activities of distinct signaling pathways, including different insulin-like peptides, to promote physiological changes that ultimately affect lifespan. ..
  21. pmc Dietary sugar promotes systemic TOR activation in Drosophila through AKH-dependent selective secretion of Dilp3
    Jung Kim
    Department of Genetics, Cell Biology and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, Minnesota 55455, USA
    Nat Commun 6:6846. 2015
    ..Thus, IPCs integrate multiple cues to regulate the secretion of distinct insulin subtypes under varying nutrient conditions. ..
  22. doi Cell mixing induced by myc is required for competitive tissue invasion and destruction
    Romain Levayer
    Institute for Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland
    Nature 524:476-80. 2015
    ..Our results establish the first link between cell-cell intercalation induced by a proto-oncogene and how it promotes invasiveness and destruction of healthy tissues. ..
  23. pmc Nutritional Geometric Profiles of Insulin/IGF Expression in Drosophila melanogaster
    Stephanie Post
    Department of Molecular Biology, Cell Biology and Biochemistry, Providence, RI, Brown University, United States of America
    PLoS ONE 11:e0155628. 2016
    ..To understand how dietary protein and sugar affect dilp expression, we followed the analytical concepts of the Nutritional Geometric Framework, feeding Drosophila adults ..
  24. pmc Drosophila insulin-like peptide 1 (DILP1) is transiently expressed during non-feeding stages and reproductive dormancy
    Yiting Liu
    Department of Zoology, Stockholm University, S 10691 Stockholm, Sweden
    Sci Rep 6:26620. 2016
    ..In Drosophila, eight insulin-like peptides (DILP1-8) are known, six of which have been investigated in some detail, whereas expression and functions of DILP1 and ..
  25. doi Drosophila ia2 modulates secretion of insulin-like peptide
    Jihyun Kim
    Department of Molecular Biology, Sejong University, 98 Kunja dong, Kwangjin ku 143 747, Seoul, South Korea
    Comp Biochem Physiol A Mol Integr Physiol 151:180-4. 2008
    ..As the pancreas develops from the gut during vertebrate development, our results suggest a possible role of IA-2 in insulin and hexokinase regulation...
  26. ncbi The Drosophila retained/dead ringer gene and ARID gene family function during development
    Tetyana Shandala
    Centre for the Molecular Genetics of Development and Dept of Molecular Biosciences, Adelaide University, SA, Australia
    Int J Dev Biol 46:423-30. 2002
    ..Finally, we have used germline clone analysis to reveal a requirement for retn/dri in the Drosophila preblastoderm syncytial mitoses...
  27. doi Molecular evolution of the ligands of the insulin-signaling pathway: dilp genes in the genus Drosophila
    Sara Guirao-Rico
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Mol Biol Evol 28:1557-60. 2011
    Drosophila melanogaster, unlike mammals, has seven insulin-like peptides (DILPS). In Drosophila, all seven genes (dilp1-7) are single copy in the 12 species studied, except for D. grimshawi with two tandem copies of dilp2...
  28. doi Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster
    Kyu Sun Lee
    Aging Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, Republic of Korea
    FEBS Lett 583:2573-7. 2009
    ..These results indicate that sNPF1 and sNPF2 peptides processed from the sNPF precursor are sufficient for regulating body growth through the ERK-insulin pathway in Drosophila...
  29. pmc Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan
    Dickon M Humphrey
    MRC Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Exp Gerontol 44:316-27. 2009
    ..These data suggest that lowering mitochondrial coupling by high expression of hUCP3 alters mNSC function in a way that appears to increase DILP-levels in fly heads and lead to a concomitant decrease in lifespan.
  30. ncbi Dynamics of the action of dFOXO on adult mortality in Drosophila
    Maria E Giannakou
    Centre for Research on Ageing, Department of Biology, University College London, London, UK
    Aging Cell 6:429-38. 2007
    ..The decreased mortality and increased lifespan of dFOXO overexpressing flies was uncoupled from any effect on female fecundity and from expression levels of Drosophila insulin-like peptides in the brain...
  31. ncbi Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain
    Begona De Velasco
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Biol 302:309-23. 2007
    ..NSCs labeled by the expression of Drosophila insulin-like peptide (Dilp), FMRF, and myomodulin form part of the Dchx1 expressing PI domain...
  32. ncbi Body-size regulation: combining genetics and physiology
    Alexander W Shingleton
    Guyot Hall, Princeton University, Princeton, New Jersey 08544, USA
    Curr Biol 15:R825-7. 2005
    ..New research has revealed that the activity of the insulin-signaling pathway in the prothoracic gland of Drosophila modulates ecdysone release and thereby influences both the duration and rate of larval growth...
  33. ncbi Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005
    ..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
  34. ncbi Amino acids and the humoral regulation of growth: fat bodies use slimfast
    Gemma L Bradley
    BioMed Central, Middlesex House, 34 42 Cleveland Street, W1T 4LB, London, United Kingdom
    Cell 114:656-8. 2003
    ..In this issue of Cell, Colombani et al. demonstrate that amino acid-responsive TOR signaling in the Drosophila fat body modulates insulin signaling and growth in peripheral tissues...
  35. ncbi Insulin-related peptides and their conserved signal transduction pathway
    Ilse Claeys
    Laboratory for Developmental Physiology and Molecular Biology, K U, Leuven, Belgium
    Peptides 23:807-16. 2002
    ....
  36. ncbi Growth control: invertebrate insulin surprises!
    S J Leevers
    Ludwig Institute for Cancer Research, 91 Riding House Street, W1W 7BS, London, UK
    Curr Biol 11:R209-12. 2001
    ..Invertebrates have been found to possess more insulin-like ligands than predicted, some of which behave as receptor antagonists...