Genomes and Genes
Gene Symbol: Hph
Description: HIF prolyl hydroxylase
Alias: 0303/04, 31543, CG1114, CG14665, CG2676, CG31543, CG44015, CR31541, Dm.egl-9, Dmel\CG44015, Dmel_CG31543, Dmel_CR31541, PHD, anon-EST:Posey69, dHPH, dPHD, dPHD2, dmHPH, fga, hph, l(3)02255, l(3)82Fe, l(3)S030304, CG44015 gene product from transcript CG44015-RD, CG44015-PA, CG44015-PB, CG44015-PC, CG44015-PD, HIF prolyl 4-hydroxylase, HIF-1a prolyl hyroxylase, Hph-PA, Hph-PB, Hph-PC, Hph-PD, fatiga, lethal (3) 82Fe, lethal (3) S030304, lopped, prolyl-4-hydroxylase
Species: fruit fly
- A conserved family of prolyl-4-hydroxylases that modify HIFR K Bruick
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
Science 294:1337-40. 2001..We identified a conserved family of HIF prolyl hydoxylase (HPH) enzymes that appear to be responsible for this posttranslational modification...
- Evolutionary conserved regulation of HIF-1β by NF-κBPatrick van Uden
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom
PLoS Genet 7:e1001285. 2011..Significantly, NF-κB regulates HIF-1β (tango) and HIF-α (sima) levels and activity (Hph/fatiga, ImpL3/ldha) in Drosophila, both in normoxia and hypoxia, indicating an evolutionary conserved mode of regulation...
- Oxygen sensing in Drosophila: multiple isoforms of the prolyl hydroxylase fatiga have different capacity to regulate HIFalpha/SimaJulieta M Acevedo
Instituto Leloir, Buenos Aires, Argentina
PLoS ONE 5:e12390. 2010..PHD2, the longest PHD isoform includes a MYND domain, whose biochemical function is unclear...
- Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sproutingLazaro Centanin
Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
Dev Cell 14:547-58. 2008..extra sprouting depends on the Hypoxia-Inducible Factor (HIF)-alpha homolog Sima and on the HIF-prolyl hydroxylase Fatiga that operates as an oxygen sensor...
- Analysis of the hypoxia-sensing pathway in Drosophila melanogasterNathalie Arquier
Neurobiologie Vasculaire, INSERM U615, Universite de Nice Sophia Antipolis, Parc Valrose, Nice 06108, Nice Cedex 02, France
Biochem J 393:471-80. 2006..hypoxia induces gene transcription involves the inhibition of HIF-1alpha (hypoxia-inducible factor-1 alpha subunit) PHD (prolyl hydroxylase) activity, which prevents the VHL (von Hippel-Lindau)-dependent targeting of HIF-1alpha to the ..
- Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growthChristian Frei
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
Dev Cell 6:241-51. 2004..Loss-of-function mutations in Hif-1 prolyl hydroxylase (Hph), an enzyme involved in the cellular response to hypoxic stress, dominantly suppress the growth but not the ..
- Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similarSofía Lavista-Llanos
Instituto de Investigaciones Bioquimicas Fundacion Campomar, Buenos Aires 1405, Argentina
Mol Cell Biol 22:6842-53. 2002..Abrogation of the Drosophila Egl-9 prolyl hydroxylase homologue, CG1114, caused both stabilization and nuclear localization of Sima, indicating a central involvement in both processes...
- Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/SimaLazaro Centanin
Instituto Leloir and IIB, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
EMBO Rep 6:1070-5. 2005..Here, we describe novel loss-of-function mutants of fatiga, the gene encoding the Drosophila PHD oxygen sensor, which manifest growth defects and lethality...
- A conserved polybasic domain mediates plasma membrane targeting of Lgl and its regulation by hypoxiaWei Dong
Department of Cell Biology, University of Pittsburgh Medical School, Pittsburgh, PA 15261
J Cell Biol 211:273-86. 2015....
- HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signalsDaniel Bandarra
Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, DD1 5EH, UK
Dis Model Mech 8:169-81. 2015..These results indicate that HIF-1α is required to restrain the NF-κB response, and thus prevents excessive and damaging pro-inflammatory responses. ..
- Nucleoporin Nup98 associates with Trx/MLL and NSL histone-modifying complexes and regulates Hox gene expressionPau Pascual-García
Department of Cell and Developmental Biology, Penn Epigenetics Program, University of Pennsylvania, 9 101 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
Cell Rep 9:433-42. 2014..These findings introduce roles of Nup98 in epigenetic regulation that may underlie the basis of oncogenicity of Nup98 fusions in leukemia...
- Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1Nathan A Baird
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
J Biol Chem 281:38675-81. 2006..This cross-regulation represents a mechanism by which the low oxygen response pathway has assimilated complex new functions by regulating the key transcriptional activator of the heat shock pathway...
- HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogasterYan Li
Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
PLoS Genet 9:e1003230. 2013..These results indicate that competent hypoxic responses arise from complex interactions between HIF-dependent and -independent mechanisms, and that dERR plays a central role in both of these programs...
- Dose-dependent modulation of HIF-1alpha/sima controls the rate of cell migration and invasion in Drosophila ovary border cellsS Doronkin
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Oncogene 29:1123-34. 2010..generated a range of phenotypes, including blocked, delayed and accelerated BCM, whereas over-expression of hph (Drosophila HIF prolyl hydroxylase) only accelerated BCM...
- A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal systemAmin S Ghabrial
Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
PLoS Genet 7:e1002087. 2011....
- Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cellsTina Mukherjee
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
Science 332:1210-3. 2011..Studies in vertebrate myeloid cells have shown a similar up-regulation of Hif-α protein in well-oxygenated environments. This study provides a mechanistic paradigm for Hif-α/Notch interaction that may be conserved in mammals...
- Molecular evolution of the metazoan PHD-HIF oxygen-sensing systemKalle T Rytkönen
Division of Genetics and Physiology, Department of Biology, University of Turku, Turku, Finland
Mol Biol Evol 28:1913-26. 2011..HIF alpha proteins are commonly posttranslationally regulated by prolyl-4-hydroxylase (PHD) enzymes, which are direct "sensors" of cellular oxygen levels...
- Mammalian cyclin D1/Cdk4 complexes induce cell growth in DrosophilaSanjeev A Datar
Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington, USA
Cell Cycle 5:647-52. 2006..Furthermore, Hif-1 prolyl hydroxylase (Hph) is required for both complexes to drive growth...
- A breath of fresh air for cyclin D/Cdk4: triggering growth via HphRobert J Duronio
Department of Biology, Program in Molecular Biology and Biotechnology, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
Dev Cell 6:163-4. 2004..In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4-stimulated growth requires Hph, a prolyl hydroxylase that is a key component of a cell's ability to respond to hypoxia.
- Characterization and comparative analysis of the EGLN gene familyM S Taylor
Medical Genetics Section, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
Gene 275:125-32. 2001..These results provide new insights into host-pathogen interactions and a basis for further functional characterization of the gene family and resolve discrepancies in annotation between gene family members...
- Central role of the oxygen-dependent degradation domain of Drosophila HIFalpha/Sima in oxygen-dependent nuclear exportMaximiliano Irisarri
Instituto Leloir and FCEyN, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1405 Buenos Aires, Argentina
Mol Biol Cell 20:3878-87. 2009..HIFalpha/Sima nucleo-cytoplasmic localization is the result of a dynamic equilibrium between nuclear import and nuclear export, and nuclear export is modulated by oxygen tension...
- Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasisLeigh Cuttell
Medical Research Council Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Cell and Developmental Biology Department, University College London, Gower Street, London WC1E 6BT, UK
Cell 135:524-34. 2008..Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway...
- The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesisRachael L French
Program in Genetics, Department of Genome Sciences, University of Washington, Box 357730, Seattle, Washington, 98195 7730, USA
Dev Biol 253:18-35. 2003..We hypothesize that loss of Ttk69 in all follicle cells disrupts chorion gene expression and lack of function in dorsal anterior follicle cells inhibits morphogenetic changes required for elongating the dorsal appendages...
- Collagens, modifying enzymes and their mutations in humans, flies and wormsJohanna Myllyharju
Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
Trends Genet 20:33-43. 2004..elegans mutants are also available to analyse the collagen gene family and their modifying enzymes...
- The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growthChristian Frei
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
EMBO J 24:623-34. 2005..CycD/Cdk4 stimulates mitochondrial activity, and this is mRpL12 dependent. Hif-1 prolyl hydroxylase (Hph), another effector of CycD/Cdk4, regulates growth and is required for inhibition of the hypoxia-inducible ..