Hph

Summary

Gene Symbol: Hph
Description: HIF prolyl hydroxylase
Alias: 0303/04, 31543, CG1114, CG14665, CG2676, CG31543, CG44015, CR31541, Dm.egl-9, Dmel\CG44015, Dmel_CG31543, Dmel_CR31541, PHD, anon-EST:Posey69, dHPH, dPHD, dPHD2, dmHPH, fga, hph, l(3)02255, l(3)82Fe, l(3)S030304, CG44015 gene product from transcript CG44015-RD, CG44015-PA, CG44015-PB, CG44015-PC, CG44015-PD, HIF prolyl 4-hydroxylase, HIF-1a prolyl hyroxylase, Hph-PA, Hph-PB, Hph-PC, Hph-PD, fatiga, lethal (3) 82Fe, lethal (3) S030304, lopped, prolyl-4-hydroxylase
Species: fruit fly

Top Publications

  1. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
  2. pmc Evolutionary conserved regulation of HIF-1β by NF-κB
    Patrick van Uden
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS Genet 7:e1001285. 2011
  3. pmc Oxygen sensing in Drosophila: multiple isoforms of the prolyl hydroxylase fatiga have different capacity to regulate HIFalpha/Sima
    Julieta M Acevedo
    Instituto Leloir, Buenos Aires, Argentina
    PLoS ONE 5:e12390. 2010
  4. doi Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting
    Lazaro Centanin
    Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Dev Cell 14:547-58. 2008
  5. pmc Analysis of the hypoxia-sensing pathway in Drosophila melanogaster
    Nathalie Arquier
    Neurobiologie Vasculaire, INSERM U615, Universite de Nice Sophia Antipolis, Parc Valrose, Nice 06108, Nice Cedex 02, France
    Biochem J 393:471-80. 2006
  6. ncbi Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Dev Cell 6:241-51. 2004
  7. pmc Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar
    Sofía Lavista-Llanos
    Instituto de Investigaciones Bioquimicas Fundacion Campomar, Buenos Aires 1405, Argentina
    Mol Cell Biol 22:6842-53. 2002
  8. pmc Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima
    Lazaro Centanin
    Instituto Leloir and IIB, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    EMBO Rep 6:1070-5. 2005
  9. pmc A conserved polybasic domain mediates plasma membrane targeting of Lgl and its regulation by hypoxia
    Wei Dong
    Department of Cell Biology, University of Pittsburgh Medical School, Pittsburgh, PA 15261
    J Cell Biol 211:273-86. 2015
  10. pmc HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals
    Daniel Bandarra
    Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, DD1 5EH, UK
    Dis Model Mech 8:169-81. 2015

Scientific Experts

  • S Doronkin
  • Amin S Ghabrial
  • J Myllyharju
  • M S Taylor
  • Christian Frei
  • Lazaro Centanin
  • Pablo Wappner
  • Maximiliano Irisarri
  • Andres Dekanty
  • Daniel Bandarra
  • Wei Dong
  • Pau Pascual-García
  • Yan Li
  • Sharon Mudie
  • Sonia Rocha
  • Sofía Lavista-Llanos
  • Kalle T Rytkönen
  • Tina Mukherjee
  • Patrick van Uden
  • Julieta M Acevedo
  • Leigh Cuttell
  • Nathalie Arquier
  • Nathan A Baird
  • Sanjeev A Datar
  • Robert J Duronio
  • Peter J Ratcliffe
  • Rachael L French
  • Erin Austin
  • Juan Huang
  • H Arno J Müller
  • Yu Jiang
  • Xuejing Zhang
  • Yang Hong
  • John Biddlestone
  • Weijie Liu
  • Alicia M Celotto
  • Wendy Z Jiang
  • Yi Jiun Chen
  • Michael J Palladino
  • Gerald R V Hammond
  • Maya Capelson
  • Jieun Jeong
  • Robert B Beckstead
  • Divya Padmanabha
  • Catherine I Dumur
  • Luciana B Gentile
  • Keith D Baker
  • R K Bruick
  • H Arno Müller
  • Lolitika Mandal
  • William Sang Kim
  • Utpal Banerjee
  • Niall S Kenneth
  • Mikko Nikinmaa
  • Ryan Webster
  • Tom A Williams
  • Gillian M Renshaw
  • Craig R Primmer
  • Nuria M Romero
  • Emeline Van Goethem
  • Elizabeth Silva
  • Nuria Romero
  • Nathalie C Franc
  • Claire J Escaron
  • Jean Pierre Eid
  • Thomas A Gorr
  • Magali Quirin
  • Mark Lavine
  • Andrew Vaughan
  • Bruce A Edgar
  • Gisela D'Angelo
  • Mark Marti
  • Douglas W Turnbull
  • Tien Hsu
  • Aida de la Cruz
  • Eric A Johnson
  • Paul Vigne
  • Christian Frelin
  • Mireille Galloni
  • Pascal P Therond
  • Eric Duplan
  • K Amber Cosand
  • Celeste A Berg
  • Daniela M Russo
  • Mariana Muzzopappa
  • Silvia N Bocca
  • Jonathan M Gleadle
  • S L McKnight

Detail Information

Publications25

  1. ncbi A conserved family of prolyl-4-hydroxylases that modify HIF
    R K Bruick
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
    Science 294:1337-40. 2001
    ..We identified a conserved family of HIF prolyl hydoxylase (HPH) enzymes that appear to be responsible for this posttranslational modification...
  2. pmc Evolutionary conserved regulation of HIF-1β by NF-κB
    Patrick van Uden
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    PLoS Genet 7:e1001285. 2011
    ..Significantly, NF-κB regulates HIF-1β (tango) and HIF-α (sima) levels and activity (Hph/fatiga, ImpL3/ldha) in Drosophila, both in normoxia and hypoxia, indicating an evolutionary conserved mode of regulation...
  3. pmc Oxygen sensing in Drosophila: multiple isoforms of the prolyl hydroxylase fatiga have different capacity to regulate HIFalpha/Sima
    Julieta M Acevedo
    Instituto Leloir, Buenos Aires, Argentina
    PLoS ONE 5:e12390. 2010
    ..PHD2, the longest PHD isoform includes a MYND domain, whose biochemical function is unclear...
  4. doi Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting
    Lazaro Centanin
    Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Dev Cell 14:547-58. 2008
    ..extra sprouting depends on the Hypoxia-Inducible Factor (HIF)-alpha homolog Sima and on the HIF-prolyl hydroxylase Fatiga that operates as an oxygen sensor...
  5. pmc Analysis of the hypoxia-sensing pathway in Drosophila melanogaster
    Nathalie Arquier
    Neurobiologie Vasculaire, INSERM U615, Universite de Nice Sophia Antipolis, Parc Valrose, Nice 06108, Nice Cedex 02, France
    Biochem J 393:471-80. 2006
    ..hypoxia induces gene transcription involves the inhibition of HIF-1alpha (hypoxia-inducible factor-1 alpha subunit) PHD (prolyl hydroxylase) activity, which prevents the VHL (von Hippel-Lindau)-dependent targeting of HIF-1alpha to the ..
  6. ncbi Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024, Seattle, WA 98109, USA
    Dev Cell 6:241-51. 2004
    ..Loss-of-function mutations in Hif-1 prolyl hydroxylase (Hph), an enzyme involved in the cellular response to hypoxic stress, dominantly suppress the growth but not the ..
  7. pmc Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar
    Sofía Lavista-Llanos
    Instituto de Investigaciones Bioquimicas Fundacion Campomar, Buenos Aires 1405, Argentina
    Mol Cell Biol 22:6842-53. 2002
    ..Abrogation of the Drosophila Egl-9 prolyl hydroxylase homologue, CG1114, caused both stabilization and nuclear localization of Sima, indicating a central involvement in both processes...
  8. pmc Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima
    Lazaro Centanin
    Instituto Leloir and IIB, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    EMBO Rep 6:1070-5. 2005
    ..Here, we describe novel loss-of-function mutants of fatiga, the gene encoding the Drosophila PHD oxygen sensor, which manifest growth defects and lethality...
  9. pmc A conserved polybasic domain mediates plasma membrane targeting of Lgl and its regulation by hypoxia
    Wei Dong
    Department of Cell Biology, University of Pittsburgh Medical School, Pittsburgh, PA 15261
    J Cell Biol 211:273-86. 2015
    ....
  10. pmc HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals
    Daniel Bandarra
    Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dow Street, DD1 5EH, UK
    Dis Model Mech 8:169-81. 2015
    ..These results indicate that HIF-1α is required to restrain the NF-κB response, and thus prevents excessive and damaging pro-inflammatory responses. ..
  11. doi Nucleoporin Nup98 associates with Trx/MLL and NSL histone-modifying complexes and regulates Hox gene expression
    Pau Pascual-García
    Department of Cell and Developmental Biology, Penn Epigenetics Program, University of Pennsylvania, 9 101 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Cell Rep 9:433-42. 2014
    ..These findings introduce roles of Nup98 in epigenetic regulation that may underlie the basis of oncogenicity of Nup98 fusions in leukemia...
  12. ncbi Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor-1
    Nathan A Baird
    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA
    J Biol Chem 281:38675-81. 2006
    ..This cross-regulation represents a mechanism by which the low oxygen response pathway has assimilated complex new functions by regulating the key transcriptional activator of the heat shock pathway...
  13. pmc HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogaster
    Yan Li
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS Genet 9:e1003230. 2013
    ..These results indicate that competent hypoxic responses arise from complex interactions between HIF-dependent and -independent mechanisms, and that dERR plays a central role in both of these programs...
  14. doi Dose-dependent modulation of HIF-1alpha/sima controls the rate of cell migration and invasion in Drosophila ovary border cells
    S Doronkin
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Oncogene 29:1123-34. 2010
    ..generated a range of phenotypes, including blocked, delayed and accelerated BCM, whereas over-expression of hph (Drosophila HIF prolyl hydroxylase) only accelerated BCM...
  15. pmc A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system
    Amin S Ghabrial
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
    PLoS Genet 7:e1002087. 2011
    ....
  16. pmc Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells
    Tina Mukherjee
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Science 332:1210-3. 2011
    ..Studies in vertebrate myeloid cells have shown a similar up-regulation of Hif-α protein in well-oxygenated environments. This study provides a mechanistic paradigm for Hif-α/Notch interaction that may be conserved in mammals...
  17. doi Molecular evolution of the metazoan PHD-HIF oxygen-sensing system
    Kalle T Rytkönen
    Division of Genetics and Physiology, Department of Biology, University of Turku, Turku, Finland
    Mol Biol Evol 28:1913-26. 2011
    ..HIF alpha proteins are commonly posttranslationally regulated by prolyl-4-hydroxylase (PHD) enzymes, which are direct "sensors" of cellular oxygen levels...
  18. ncbi Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila
    Sanjeev A Datar
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington, USA
    Cell Cycle 5:647-52. 2006
    ..Furthermore, Hif-1 prolyl hydroxylase (Hph) is required for both complexes to drive growth...
  19. ncbi A breath of fresh air for cyclin D/Cdk4: triggering growth via Hph
    Robert J Duronio
    Department of Biology, Program in Molecular Biology and Biotechnology, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Cell 6:163-4. 2004
    ..In this issue of Developmental Cell, Frei and Edgar reveal that Cyclin D/Cdk4-stimulated growth requires Hph, a prolyl hydroxylase that is a key component of a cell's ability to respond to hypoxia.
  20. ncbi Characterization and comparative analysis of the EGLN gene family
    M S Taylor
    Medical Genetics Section, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Gene 275:125-32. 2001
    ..These results provide new insights into host-pathogen interactions and a basis for further functional characterization of the gene family and resolve discrepancies in annotation between gene family members...
  21. pmc Central role of the oxygen-dependent degradation domain of Drosophila HIFalpha/Sima in oxygen-dependent nuclear export
    Maximiliano Irisarri
    Instituto Leloir and FCEyN, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1405 Buenos Aires, Argentina
    Mol Biol Cell 20:3878-87. 2009
    ..HIFalpha/Sima nucleo-cytoplasmic localization is the result of a dynamic equilibrium between nuclear import and nuclear export, and nuclear export is modulated by oxygen tension...
  22. doi Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis
    Leigh Cuttell
    Medical Research Council Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Cell and Developmental Biology Department, University College London, Gower Street, London WC1E 6BT, UK
    Cell 135:524-34. 2008
    ..Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway...
  23. ncbi The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesis
    Rachael L French
    Program in Genetics, Department of Genome Sciences, University of Washington, Box 357730, Seattle, Washington, 98195 7730, USA
    Dev Biol 253:18-35. 2003
    ..We hypothesize that loss of Ttk69 in all follicle cells disrupts chorion gene expression and lack of function in dorsal anterior follicle cells inhibits morphogenetic changes required for elongating the dorsal appendages...
  24. ncbi Collagens, modifying enzymes and their mutations in humans, flies and worms
    Johanna Myllyharju
    Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
    Trends Genet 20:33-43. 2004
    ..elegans mutants are also available to analyse the collagen gene family and their modifying enzymes...
  25. pmc The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth
    Christian Frei
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    EMBO J 24:623-34. 2005
    ..CycD/Cdk4 stimulates mitochondrial activity, and this is mRpL12 dependent. Hif-1 prolyl hydroxylase (Hph), another effector of CycD/Cdk4, regulates growth and is required for inhibition of the hypoxia-inducible ..