hkb

Summary

Gene Symbol: hkb
Description: huckebein
Alias: 5953, CG9768, Dmel\CG9768, HKB, Hkb, anon-82B3, gurt, CG9768 gene product from transcript CG9768-RA, CG9768-PA, gurtelchen, hkb-PA, huckbein, hucklebein
Species: fruit fly

Top Publications

  1. ncbi huckebein is required for glial development and axon pathfinding in the neuroblast 1-1 and neuroblast 2-2 lineages in the Drosophila central nervous system
    T Bossing
    Institut fur Genetik, Universitat Mainz, Germany
    Mech Dev 55:53-64. 1996
  2. ncbi Interactions of the Drosophila gap gene giant with maternal and zygotic pattern-forming genes
    E D Eldon
    Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston 77030
    Development 111:367-78. 1991
  3. ncbi Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo
    G Bronner
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, F R G
    Mech Dev 35:205-11. 1991
  4. ncbi Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes
    G Riddihough
    Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK
    Genes Dev 5:840-54. 1991
  5. ncbi Regulation of Krüppel expression in the anlage of the Malpighian tubules in the Drosophila embryo
    U Gaul
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, F R G
    Mech Dev 33:57-67. 1990
  6. ncbi Pattern formation under the control of the terminal system in the Drosophila embryo
    J Casanova
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Development 110:621-8. 1990
  7. ncbi Two gap genes mediate maternal terminal pattern information in Drosophila
    D Weigel
    Universitat Munchen, Institut fur Genetik und Mikrobiologie, Federal Republic of Germany
    Science 248:495-8. 1990
  8. ncbi Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element
    J S Margolis
    Department of Biology, University of California San Diego, La Jolla 92093 0366, USA
    Development 121:3067-77. 1995
  9. ncbi Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless
    M Gonzalez-Gaitan
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Development 121:2313-25. 1995
  10. ncbi Regulation of the dorsal morphogen by the Toll and torso signaling pathways: a receptor tyrosine kinase selectively masks transcriptional repression
    J Rusch
    Department of Biology, University of California San Diego, La Jolla 92093 0322
    Genes Dev 8:1247-57. 1994

Research Grants

Scientific Experts

Detail Information

Publications115 found, 100 shown here

  1. ncbi huckebein is required for glial development and axon pathfinding in the neuroblast 1-1 and neuroblast 2-2 lineages in the Drosophila central nervous system
    T Bossing
    Institut fur Genetik, Universitat Mainz, Germany
    Mech Dev 55:53-64. 1996
    ....
  2. ncbi Interactions of the Drosophila gap gene giant with maternal and zygotic pattern-forming genes
    E D Eldon
    Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston 77030
    Development 111:367-78. 1991
    ..Expression is never detected in the labial or thoracic segment primordia but persists in certain head structures, including the ring gland, until the end of embryonic development...
  3. ncbi Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo
    G Bronner
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, F R G
    Mech Dev 35:205-11. 1991
    We have studied the genetic requirement for the normal expression of the terminal gap genes huckebein (hkb) and tailless (tll) and their possible function in the posterior pole region of the Drosophila embryo...
  4. ncbi Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes
    G Riddihough
    Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK
    Genes Dev 5:840-54. 1991
    ..Our results suggest that different but overlapping subsets of gap genes regulate each stripe and that activation and repression are both important in generating the stripe pattern...
  5. ncbi Regulation of Krüppel expression in the anlage of the Malpighian tubules in the Drosophila embryo
    U Gaul
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, F R G
    Mech Dev 33:57-67. 1990
    ..In addition, Krüppel activates different genes in the Malpighian tubules than in the central domain. Thus, both the regulation and the function of Krüppel in the Malpighian tubules differ strikingly from its role in segmentation...
  6. ncbi Pattern formation under the control of the terminal system in the Drosophila embryo
    J Casanova
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032
    Development 110:621-8. 1990
    ..Moreover, they suggest that different elements of the terminal pattern can be specified in response to distinct levels of graded tailless activity...
  7. ncbi Two gap genes mediate maternal terminal pattern information in Drosophila
    D Weigel
    Universitat Munchen, Institut fur Genetik und Mikrobiologie, Federal Republic of Germany
    Science 248:495-8. 1990
    ..The activities of tailless (tll) and the newly identified gap gene huckebein (hkb) are specifically involved in mediating the maternal terminal information at the posterior end of the blastoderm ..
  8. ncbi Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element
    J S Margolis
    Department of Biology, University of California San Diego, La Jolla 92093 0366, USA
    Development 121:3067-77. 1995
    ..We propose a model in which the anterior border of the posterior hb stripe is determined by tll concentration in a manner analogous to the activation of anterior hb expression by bicoid...
  9. ncbi Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless
    M Gonzalez-Gaitan
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Development 121:2313-25. 1995
    ..Our results suggest that the wingless pathway acts not as an instructive signal, but as a permissive factor which coordinates the spatial activity of morphoregulatory signals within the stomatogastric nervous system anlage...
  10. ncbi Regulation of the dorsal morphogen by the Toll and torso signaling pathways: a receptor tyrosine kinase selectively masks transcriptional repression
    J Rusch
    Department of Biology, University of California San Diego, La Jolla 92093 0322
    Genes Dev 8:1247-57. 1994
    ..These results suggest that RTK signaling pathways can control gene expression by antirepression, and that multiple pathways can fine-tune the activities of a single transcription factor...
  11. ncbi Interacting functions of snail, twist and huckebein during the early development of germ layers in Drosophila
    R Reuter
    Max Planck Institut fur Entwicklungsbiologie, Abteilung V, Tubingen, FR Germany
    Development 120:1137-50. 1994
    ..We show that huckebein (hkb) sets the anterior and the posterior borders of the ventral furrow, but acts by different modes of regulation...
  12. ncbi Sp1/egr-like zinc-finger protein required for endoderm specification and germ-layer formation in Drosophila
    G Bronner
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Nature 369:664-8. 1994
    ..Here we show that the Drosophila gene huckebein (hkb), a member of the gap-gene class of segmentation genes, is required for germ-layer formation at blastoderm...
  13. ncbi Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade
    E Ronchi
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Cell 74:347-55. 1993
    ..We propose that phosphorylation resulting from the activity of the tor signal transduction cascade down-regulates transcriptional activation by the bcd morphogen...
  14. ncbi Regulation and function of the terminal gap gene huckebein in the Drosophila blastoderm
    G Bronner
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Int J Dev Biol 40:157-65. 1996
    ..Here we show that the Drosophila gene huckebein (hkb), a member of the gap gene class of segmentation genes, is not only required for suppression of segmentation in the ..
  15. ncbi The embryonic central nervous system lineages of Drosophila melanogaster. I. Neuroblast lineages derived from the ventral half of the neuroectoderm
    T Bossing
    Institut fur Genetik, Universitat Mainz, Germany
    Dev Biol 179:41-64. 1996
    ..The wild-type clones provide a foundation for the analysis of mutants, expression patterns, and experimental manipulations...
  16. ncbi From gradients to stripes in Drosophila embryogenesis: filling in the gaps
    R Rivera-Pomar
    Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Trends Genet 12:478-83. 1996
    ..Recent progress has begun to reveal the mechanisms by which coherent positional information of maternal origin becomes transferred into serially repeated zygotic gene expression domains reflecting the metameric body plan of the larva...
  17. ncbi Establishing neuroblast-specific gene expression in the Drosophila CNS: huckebein is activated by Wingless and Hedgehog and repressed by Engrailed and Gooseberry
    J A McDonald
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 124:1079-87. 1997
    ..Integration of these activation and repression inputs is required to establish the precise neuroectodermal pattern of huckebein, which is subsequently required for the development of specific neuroblast cell lineages...
  18. ncbi Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression
    Z Paroush
    Imperial Cancer Research Fund, London, UK
    Development 124:3827-34. 1997
    ..at the poles of the embryo triggers restricted expression of the zygotic gap genes tailless (tll) and huckebein (hkb)...
  19. ncbi Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos
    S Greenwood
    Howard Hughes Medical Institute, and Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 124:4879-86. 1997
    ..Tor activity elicits the transcription of two 'gap' genes, tailless (tll) and huckebein (hkb), in overlapping but distinct domains by stimulating the Ras signal transduction pathway...
  20. ncbi Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila
    C Ghiglione
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Biol 205:181-93. 1999
    ..Altogether, our results illustrate how a gradient of MAPK activity controls differential gene expression and, thus, the establishment of various cell fates. We discuss the roles of quantitative mechanisms in defining RTK specificity...
  21. pmc Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo
    H Zhang
    Department of Molecular and Cell Biology, Division of Genetics and Development, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 96:535-40. 1999
    ..These results suggest that dCtBP and Groucho mediate separate pathways of transcriptional repression and that the two proteins can inhibit one another when both bind the same repressor...
  22. ncbi Sloppy paired acts as the downstream target of wingless in the Drosophila CNS and interaction between sloppy paired and gooseberry inhibits sloppy paired during neurogenesis
    K M Bhat
    Department of Cell Biology, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
    Development 127:655-65. 2000
    ..This mechanism appears to be responsible for specifying NB5-3 identity to a row 5 neuroblast and preventing Wg from specifying NB4-2 identity to that cell...
  23. pmc Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning
    G Jimenez
    Institut de Biologia Molecular de Barcelona CSIC, 08034 Barcelona, Spain
    Genes Dev 14:224-31. 2000
    ..cic has been evolutionarily conserved, suggesting that Cic-like proteins may act as repressors regulated by RTK signaling in other organisms...
  24. pmc Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries
    M Kobayashi
    Kimmel Cancer Institute, Thomas Jefferson Univ, Phila, PA 19107, USA
    Development 128:1805-15. 2001
    ..The accumulation of multiple domains of similar function within a single protein may be a common evolutionary mechanism that fine-tunes the level of activity for different regulatory functions...
  25. pmc In and out of Torso RTK signalling
    Marc Furriols
    Institut de Biologia Molecular de Barcelona CSIC, C Jordi Girona 18 26, E 08034 Barcelona, Spain
    EMBO J 22:1947-52. 2003
  26. ncbi Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Mol Cell 22:645-55. 2006
    ..Our structural and functional analysis explains the rigid conservation of the WRPW motif, the sequence flexibility of eh1 motifs, and other aspects of repressor recognition by Gro in vivo...
  27. pmc Differential in vivo requirements for oligomerization during Groucho-mediated repression
    Barbara H Jennings
    Developmental Genetics Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, UK
    EMBO Rep 9:76-83. 2008
    ..Our results show that homo-oligomerization of Gro is not obligatory for its action in vivo, and that Gro represses transcription through more than one molecular mechanism...
  28. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  29. pmc Gene circuit analysis of the terminal gap gene huckebein
    Maksat Ashyraliyev
    Center for Mathematics and Computer Science, Centrum Wiskunde and Informatica, Amsterdam, The Netherlands
    PLoS Comput Biol 5:e1000548. 2009
    ..use an integrative, systems-level approach to investigate the regulatory effect of the terminal gap gene huckebein (hkb) on gap gene expression...
  30. pmc Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains
    Ulrike Löhr
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 106:21695-700. 2009
    ..We conclude that the spatial domains of head gene expression are determined by Bcd in concert with Tor-dependent repressors...
  31. pmc Capicua DNA-binding sites are general response elements for RTK signaling in Drosophila
    Leiore Ajuria
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, Barcelona, Spain
    Development 138:915-24. 2011
    ..We conclude that Capicua octamers are general response elements for RTK signaling in Drosophila...
  32. pmc Substrate-dependent control of MAPK phosphorylation in vivo
    Yoosik Kim
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Syst Biol 7:467. 2011
    ..Substrate-dependent control of MAPK phosphorylation is a manifestation of a more general retroactive effect that should be intrinsic to all networks with covalent modification cycles...
  33. pmc Quantitative models of the mechanisms that control genome-wide patterns of transcription factor binding during early Drosophila development
    Tommy Kaplan
    Department of Molecular and Cell Biology, California Institute of Quantitative Biosciences, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 7:e1001290. 2011
    ....
  34. pmc Gene regulation by MAPK substrate competition
    Yoosik Kim
    Department of Chemical and Biological Engineering, Lewis Sigler Institute for Integrative Genomics, Princeton University, NJ 08544, USA
    Dev Cell 20:880-7. 2011
    ..A mathematical model of this interaction can explain gene expression patterns with both anteroposterior and dorsoventral polarities...
  35. doi Phosphorylation of Groucho mediates RTK feedback inhibition and prolonged pathway target gene expression
    Aharon Helman
    Department of Developmental Biology and Cancer Research, Institute of Medical Research Israel Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Curr Biol 21:1102-10. 2011
    ..Here we address this question using the Drosophila embryo, a model system that has been instrumental in elucidating the developmental functions of RTK signal transduction...
  36. pmc Whole-embryo modeling of early segmentation in Drosophila identifies robust and fragile expression domains
    Jonathan Bieler
    The Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Biophys J 101:287-96. 2011
    ....
  37. pmc A conserved developmental patterning network produces quantitatively different output in multiple species of Drosophila
    Charless C Fowlkes
    Department of Computer Science, University of California Irvine, Irvine, California, USA
    PLoS Genet 7:e1002346. 2011
    ..Our results emphasize that transcriptional networks can diverge over short evolutionary timescales and that even small changes can lead to distinct output in terms of the placement and number of equivalent cells...
  38. pmc The unconserved groucho central region is essential for viability and modulates target gene specificity
    Wiam Turki-Judeh
    Department of Chemistry and Biochemistry and Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e30610. 2012
    ..We suspect that disorder in the Gro central domains may provide the flexibility that allows this region to mediate multiple interactions required for repression...
  39. pmc Efficient reverse-engineering of a developmental gene regulatory network
    Anton Crombach
    EMBL CRG Research Unit in Systems Biology, Centre for Genomic Regulation CRG and Universitat Pompeu Fabra UPF, Barcelona, Spain
    PLoS Comput Biol 8:e1002589. 2012
    ..Only the quantitative investigation of a large number of developmental gene regulatory networks will allow us to discover whether there are rules or regularities governing development and evolution of complex multi-cellular organisms...
  40. doi A statistical fat-tail test of predicting regulatory regions in the Drosophila genome
    Jian Jun Shu
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    Comput Biol Med 42:935-41. 2012
    ..These two fatness coefficients may serve as valuable filtering indexes to predict CRMs experimentally...
  41. pmc Lack of tailless leads to an increase in expression variability in Drosophila embryos
    Hilde Janssens
    EMBL CRG Research Unit in Systems Biology, CRG Centre de Regulacio Genomica, and Universitat Pompeu Fabra UPF, Dr Aiguader 88, 08003 Barcelona, Spain
    Dev Biol 377:305-17. 2013
    ..Our analysis provides evidence that loss of canalisation in mutants could be more widespread than previously thought...
  42. ncbi Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system
    C Q Doe
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Development 116:855-63. 1992
    ..These results set the stage for investigating neuroblast specification and the mechanisms controlling neuroblast cell lineages...
  43. ncbi Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo
    S Small
    Department of Biology, New York University, New York 10003, USA
    Dev Biol 175:314-24. 1996
    ..These findings suggest a general model for the regulation of segmentation stripes, whereby enhancers integrate positional information provided by broadly distributed activators and spatially restricted repressors...
  44. ncbi Variation in the number of activated torso receptors correlates with differential gene expression
    M Furriols
    Centre d Investigació i Desenvolupament CSIC C Jordi Girona 18 26, Barcelona, Spain
    Development 122:2313-7. 1996
    ..We suggest that variation in the number of activated receptors at the cell surface is a general mechanism that leads to differential gene expression and thus the generation of different cell responses...
  45. ncbi On the dynamic nature of positional information
    Johannes Jaeger
    Laboratory of Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Bioessays 28:1102-11. 2006
    ..Based on this analysis, we propose a revised French Flag, which incorporates the dynamic, feedback-driven nature of pattern formation in the Drosophila blastoderm...
  46. pmc A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling
    Sergio Astigarraga
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, Barcelona, Spain
    EMBO J 26:668-77. 2007
    ..Finally, we describe differences in the modes of Capicua downregulation by Torso and EGFR signaling, raising the possibility that such differences contribute to the tissue specificity of both signals...
  47. ncbi High bicoid levels render the terminal system dispensable for Drosophila head development
    V Schaeffer
    Department of Biology, New York University, New York NY 10003 USA
    Development 127:3993-9. 2000
    ..This observation is consistent with a recent evolution of an anterior morphogenetic center consisting of Bcd and anterior Tor function...
  48. doi Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis
    Einat Cinnamon
    Department of Biochemistry, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
    Development 135:829-37. 2008
    ..We propose that phosphorylation of Groucho provides a widespread, long-term mechanism by which RTK signals control target gene expression...
  49. ncbi Morphogenesis. Control of epithelial cell shape changes
    M Leptin
    Institut fur Genetik, Universitat zu Koln, Germany
    Curr Biol 4:709-12. 1994
    ..Cell-shape changes in the gastrulating Drosophila embryo generate two epithelial invaginations. These changes are regulated by four transcription factors, and folded gastrulation is a candidate downstream effector...
  50. ncbi A role for the mesoderm in endodermal migration and morphogenesis in Drosophila
    R Reuter
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, FR Germany
    Development 119:1135-45. 1993
    ..We conclude that the visceral mesoderm serves as a substratum for the migrating endodermal cells and that the contact between visceral mesoderm and endoderm is required for the latter to become an epithelium...
  51. ncbi Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT
    M L Yip
    Division of Biology, California Institute of Technology, Pasadena, USA
    Development 124:2129-41. 1997
    ..Second, hindsight might function both to maintain the amnioserosa and to regulate chemical signaling from the amnioserosa to the epidermal ectoderm, thus coordinating the cell shape changes and movements that drive germ-band retraction...
  52. pmc Regulatory DNA required for vnd/NK-2 homeobox gene expression pattern in neuroblasts
    Xiaoping Shao
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, and Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 4036, USA
    Proc Natl Acad Sci U S A 99:113-7. 2002
    ....
  53. ncbi Early genes required for salivary gland fate determination and morphogenesis in Drosophila melanogaster
    M M Myat
    Department of Cell Biology and Anatomy, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205 2196, USA
    Adv Dent Res 14:89-98. 2000
    ..We have characterized three genes encoding transcription factors, trachealess (trh), hückebein (hkb), and fork head (fkh), that are downstream targets of the salivary gland regulators...
  54. ncbi Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane
    Monn Monn Myat
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Cell 111:879-91. 2002
    ..branching and bulging of the normally unbranched salivary tube, in part through prolonged expression of huckebein (hkb)...
  55. ncbi An endoderm-specific GATA factor gene, dGATAe, is required for the terminal differentiation of the Drosophila endoderm
    Takashi Okumura
    Department of Physics, Biology, and Informatics, Yamaguchi University, Yamaguchi 753 8512, Japan
    Dev Biol 278:576-86. 2005
    ..This pathway is triggered by sequential signaling through the maternal torso gene, a terminal gap gene, huckebein (hkb), and finally, two GATA factor genes, srp and dGATAe.
  56. doi Nonparametric variable selection and modeling for spatial and temporal regulatory networks
    Anil Aswani
    Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, California, USA
    Methods Cell Biol 110:243-61. 2012
    ..By being able to quantify a continuum of interaction likelihoods, this helps to direct future experiments...
  57. pmc A statistical thin-tail test of predicting regulatory regions in the Drosophila genome
    Jian Jun Shu
    School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore
    Theor Biol Med Model 10:11. 2013
    ....
  58. pmc BioPreDyn-bench: a suite of benchmark problems for dynamic modelling in systems biology
    Alejandro F Villaverde
    Bioprocess Engineering Group, IIM CSIC, Eduardo Cabello 6, Vigo, 36208, Spain
    BMC Syst Biol 9:8. 2015
    ..However, there is a lack of suitable benchmark problems which allow a fair and systematic evaluation and comparison of these contributions...
  59. ncbi The engrailed and huckebein genes are essential for development of serotonin neurons in the Drosophila CNS
    M J Lundell
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Mol Cell Neurosci 7:46-61. 1996
    ..neurons of the Drosophila nerve cord is dependent on the expression of two pattern formation genes, huckebein (hkb) and engrailed (en)...
  60. pmc Inference of gene regulatory networks based on a universal minimum description length
    JOHN DOUGHERTY
    Institute of Signal Processing, Tampere University of Technology, Tampere, Finland
    EURASIP J Bioinform Syst Biol . 2008
    ..Finally, it is applied to time-series Drosophila gene expression measurements...
  61. pmc HLH54F is required for the specification and migration of longitudinal gut muscle founders from the caudal mesoderm of Drosophila
    Afshan Ismat
    Mount Sinai School of Medicine, Department of Molecular, Cell and Developmental Biology currently Developmental and Regenerative Biology, Box 1020, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 137:3107-17. 2010
    ..We conclude that HLH54F is the earliest specific regulator of CVM development and that it plays a pivotal role in all major aspects of development and differentiation of this largely twist-independent population of mesodermal cells...
  62. pmc Generalizing moving averages for tiling arrays using combined p-value statistics
    Katerina J Kechris
    University of Colorado Denver, CO, USA
    Stat Appl Genet Mol Biol 9:Article29. 2010
    ..We also present an application for the generalization of the moving average based on integrating two different tiling array experiments...
  63. doi Huckebein is part of a combinatorial repression code in the anterior blastoderm
    Luiz Paulo Andrioli
    Departamento de Genética e Biologia Evolutiva, Instituto de Biociencias, Universidade Sao Paulo, R do Matão, 277, Cidade Universitaria, 05508 000, Sao Paulo, SP, Brazil
    Dev Biol 361:177-85. 2012
    ..In this study, we investigated huckebein (hkb), which has a gap expression domain at the anterior tip of the embryo...
  64. ncbi The molecular genetics of tail development in Drosophila melanogaster
    L A Perkins
    Department of Genetics, Harvard Medical School, Boston, MA 02115
    In Vivo 5:521-31. 1991
    ....
  65. ncbi Interaction between torso and dorsal, two elements of different transduction pathways in the Drosophila embryo
    J Casanova
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
    Mech Dev 36:41-5. 1991
    ..Due to the interaction of these two systems, both of which use transmembrane signalling mechanisms, the poles adopt a more dorsalized fate than their counterparts in the middle of the embryo...
  66. ncbi Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development
    T Pawson
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Trends Genet 6:350-6. 1990
    ....
  67. ncbi huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding
    Q Chu-LaGraff
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Neuron 15:1041-51. 1995
    ..Thus, huckebein regulates aspects of GMC and neuronal identity required for proper motoneuron axon pathfinding in the NB 4-2 lineage...
  68. ncbi Spatial regulation of segment polarity gene expression in the anterior terminal region of the Drosophila blastoderm embryo
    J Mohler
    Department of Biological Sciences, Barnard College, New York, NY 10027, USA
    Mech Dev 50:151-61. 1995
    The effects of mutations in five anterior gap genes (hkb, tll, otd, ems and btd) on the spatial expression of the segment polarity genes, wg and hh, were analyzed at the late blastoderm stage and during subsequent development...
  69. ncbi An oncogenic form of human raf can specify terminal body pattern in Drosophila
    J Casanova
    Centre d Investigació i Desenvolupament CSIC, Barcelona, Spain
    Mech Dev 48:59-64. 1994
    ..This ligand triggers the localized transcription of two gap segmentation genes, tailles (tll) and huckebein (hkb) through a signal transduction cascade involving the receptor tyrosine kinase torso (tor) and homologues of ras, ..
  70. pmc Setting limits on homeotic gene function: restraint of Sex combs reduced activity by teashirt and other homeotic genes
    D J Andrew
    Department of Developmental Biology, Stanford University School of Medicine, CA 94305 5427
    EMBO J 13:1132-44. 1994
    ..Therefore, spatial restrictions on homeotic gene activity differ between tissues and result both from the regulation of homeotic gene transcription and from restraints on where homeotic proteins can function...
  71. pmc Number, identity, and sequence of the Drosophila head segments as revealed by neural elements and their deletion patterns in mutants
    U Schmidt-Ott
    Abteilung Zellbiologie, Universitat Mainz, Germany
    Proc Natl Acad Sci U S A 91:8363-7. 1994
    ....
  72. ncbi Homologs of the mouse Brachyury gene are involved in the specification of posterior terminal structures in Drosophila, Tribolium, and Locusta
    A Kispert
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    Genes Dev 8:2137-50. 1994
    ..first at the blastoderm stage in the hindgut primordium under the control of the terminal gap genes tll and hkb, and then until the end of embryogenesis in the differentiating hindgut...
  73. ncbi Primordial germ cell migration in Drosophila melanogaster is controlled by somatic tissue
    M K Jaglarz
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110
    Development 120:83-9. 1994
    ..Using mutations, we show that these controlling somatic events probably occur in the tissue of the gut primordium itself...
  74. ncbi Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead
    E A Wimmer
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 53:235-45. 1995
    ..Finally, the terminal system takes part in the regulation of btd head stripe expression by enhancing activation at low levels of activity and repression at high levels of activity...
  75. ncbi The active migration of Drosophila primordial germ cells
    M K Jaglarz
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110, USA
    Development 121:3495-503. 1995
    ..In vivo this migration is oriented leading germ cells to the gonadal mesoderm. We suggest that this guidance involves stabilization of states of an intrinsic cellular oscillator resulting in cell polarization and oriented movement...
  76. ncbi Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK
    V Cleghon
    National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Genes Dev 10:566-77. 1996
    ..These results identify a novel mechanism whereby Tor function is regulated using compensatory signals generated from distinct autophosphorylation sites and reveal an underlying signaling pathway for terminal development...
  77. ncbi A functional homologue of goosecoid in Drosophila
    A Goriely
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Development 122:1641-50. 1996
    ..The identification of gsc target genes and/or other genes involved in similar developmental processes will allow the definition of the precise phylogenetic relationship among Gsc proteins...
  78. pmc bowel, an odd-skipped homolog, functions in the terminal pathway during Drosophila embryogenesis
    L Wang
    E A Doisy Department of Biochemistry and Molecular Biology, St Louis University Medical School, MO 63104, USA
    EMBO J 15:3182-96. 1996
    ....
  79. ncbi The patched signaling pathway mediates repression of gooseberry allowing neuroblast specification by wingless during Drosophila neurogenesis
    K M Bhat
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Development 122:2921-32. 1996
    ..The timing of the response to Gsb suggests that the specification of neuroblast identities takes place within the neuroectoderm, prior to neuroblast delamination...
  80. ncbi Neurogenesis in the insect central nervous system
    C Q Doe
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Curr Opin Neurobiol 6:18-24. 1996
    ..And finally, new cell-lineage methods are being used to determine the entire lineage of identified neuroblasts, including axon projections and synaptic contacts...
  81. ncbi The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila
    L A Perkins
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Dev Biol 180:63-81. 1996
    ..In support of this hypothesis, we demonstrate that SHP-2, a vertebrate PTPase similar to Csw and previously implicated in RTK signaling, encodes the functional vertebrate homologue of Csw...
  82. ncbi A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila
    K P Rehorn
    Institut fur Genetik, Universitat zu Koln, Germany
    Development 122:4023-31. 1996
    ..These findings imply that some aspects of the molecular mechanisms underlying blood cell development as well as endodermal differentiation are early acquisitions of metazoan evolution and may be common to most higher animals...
  83. ncbi Regulation of Drosophila spalt gene expression
    R P Kühnlein
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie Am Fassberg, Gottingen, Germany
    Mech Dev 66:107-18. 1997
    ..In addition, we provide evidence that a zygotic gene product of the terminal system, Tailless, cooperates with the maternal gene product Caudal and thereby activates gene expression in the terminal region of the embryo...
  84. ncbi Dissecting the mechanism of torso receptor activation
    M Furriols
    Centre d Investigació i Desenvolupament CSIC, Barcelona, Spain
    Mech Dev 70:111-8. 1998
    ....
  85. pmc Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesis
    H Chu
    Biochemistry Department, Brandeis University, Waltham, Massachusetts 02454 9110 USA
    Genes Dev 12:3613-24. 1998
    ..Our results are discussed in the context of the current evidence in dorsoventral patterning in the Drosophila neuroectoderm...
  86. ncbi Genetic and molecular analyses of motoneuron development
    J S Eisen
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Curr Opin Neurobiol 8:697-704. 1998
    ..Many of the same molecules participate in the guidance of both vertebrate and fly motor axons. It is less clear, however, whether the same molecular mechanisms establish vertebrate and fly motoneuron identities...
  87. pmc ebi regulates epidermal growth factor receptor signaling pathways in Drosophila
    X Dong
    Department of Biological Chemistry, Molecular Biology Institute, The School of Medicine, University of California, Los Angeles, California 90095 USA
    Genes Dev 13:954-65. 1999
    ..Proteins with related structures regulate protein degradation. Similarly, in the developing eye, ebi promotes EGFR-dependent down-regulation of Tramtrack88, an antagonist of neuronal development...
  88. ncbi A transcription unit at the ken and barbie gene locus encodes a novel Drosophila zinc finger protein
    R P Kühnlein
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Gottingen, Germany
    Mech Dev 79:161-4. 1998
    ..The P-element of the enhancer trap line l(2)02970 is inserted in the 5'-region of the transcript and causes a ken and barbie (ken) phenotype, associated with malformation of male genital structures...
  89. ncbi Segment polarity genes in neuroblast formation and identity specification during Drosophila neurogenesis
    K M Bhat
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Bioessays 21:472-85. 1999
    ....
  90. ncbi Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho
    R E Goldstein
    Department of Biochemistry, Hadassah Medical School, The Hebrew University, PO Box 12272, Jerusalem 91120, Israel
    Development 126:3747-55. 1999
    ..Taken together with our earlier results, these findings show that Groucho-repression regulates sequential aspects of terminal patterning in Drosophila...
  91. ncbi Organ shape in the Drosophila salivary gland is controlled by regulated, sequential internalization of the primordia
    M M Myat
    Department of Cell Biology and Anatomy, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205 2196, USA
    Development 127:679-91. 2000
    ..In embryos mutant for hückebein (hkb), which encodes a transcription factor, or faint sausage (fas), which encodes a cell adhesion molecule, ..
  92. ncbi Receptor tyrosine kinase signaling regulates different modes of Groucho-dependent control of Dorsal
    T Hader
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Curr Biol 10:51-4. 2000
    Transcriptional control of the Drosophila terminal gap gene huckebein (hkb) depends on Torso (Tor) receptor tyrosine kinase (RTK) signaling and the Rel/NFkappaB homolog Dorsal (DI)...
  93. ncbi Receptor tyrosine kinases: specific outcomes from general signals
    M A Simon
    Department of Biological Sciences, Stanford University, California 94305, USA
    Cell 103:13-5. 2000
  94. ncbi The CNS midline cells coordinate proper cell cycle progression and identity determination of the Drosophila ventral neuroectoderm
    J Chang
    Department of Chemistry, Konkuk University, Seoul, 143 701, Korea
    Dev Biol 227:307-23. 2000
    ..This study indicates that the CNS midline cells play important roles in the coordination of the proper cell cycle progression and the correct identity determination of the adjacent ventral neuroectoderm along the dorsoventral axis...
  95. ncbi The spatial control of Torso RTK activation: a C-terminal fragment of the Trunk protein acts as a signal for Torso receptor in the Drosophila embryo
    A Casali
    Institut de Biologia Molecular de Barcelona, CSIC, C Jordi Girona 18 26, Spain
    Development 128:1709-15. 2001
    ..We therefore propose that the restricted activation of the torso receptor is defined by the spatial control of the proteolytic processing of the trunk protein...
  96. ncbi Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS
    B Mehta
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 128:3161-8. 2001
    ..These results tie a cell-non-autonomous signaling pathway to the asymmetric division of precursor cells during neurogenesis...
  97. ncbi Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila
    Thomas E Lloyd
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 108:261-9. 2002
    ..hrs mutant animals fail to degrade active epidermal growth factor (EGF) and Torso TKRs, leading to enhanced signaling and altered embryonic patterning. These data suggest that Hrs and MVB formation function to downregulate TKR signaling...
  98. ncbi germ cell-less acts to repress transcription during the establishment of the Drosophila germ cell lineage
    Judith L Leatherman
    Cell and Molecular Biology Graduate Program, University of Pennsylvania Shool of Medicine, Philadelphia, PA 19104 6100, USA
    Curr Biol 12:1681-5. 2002
    ....
  99. ncbi Tube morphogenesis: no pipe dream in Drosophila
    Vikram Sudarsan
    Department of Biochemistry HHMI, B465 Beckman Center, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Curr Biol 13:R131-3. 2003
    ..Tubular organs have characteristic lumen sizes that are generated during development. Recent studies of tubular systems in Drosophila have implicated intracellular vesicle transport as an important step in lumen expansion...
  100. ncbi Transcriptional regulation of glial cell specification
    Gianluca Ragone
    Institut de Génétique et Biologie Moléculaire et Cellulaire, IGBMC CNRS ULP INSERM BP 10142 67404 ILLKIRCH, C U, de Strasbourg, France
    Dev Biol 255:138-50. 2003
    ..Both negative and positive regulation are required to control glide/gcm expression, indicating that gliogenesis is actively repressed in some neural lineages...
  101. pmc Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling
    Jinghong Li
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Genetics 164:247-58. 2003
    ..These results demonstrate an essential requirement of noncanonical signaling pathways for a persistently activated RTK to cause pathological defects in an organism...

Research Grants8

  1. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
    ..This research will aid in the prevention of psychiatric illness and the development of therapies for afflicted individuals. ..
  2. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  3. Receptor Tyrosine Kinase Regulation of Nuclear Import
    Lizabeth Perkins; Fiscal Year: 2004
    ..g. Csw) directly participate in the process of nuclear import will contribute to a greater understanding of how signaling pathways control cellular growth and differentiation. ..
  4. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ....
  5. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
    ..Our proposed studies will provide insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  6. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008
    ..This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback. [unreadable] [unreadable] [unreadable]..
  7. Regulation of Cell Migration by the APC-Microtubule Complex
    William Nelson; Fiscal Year: 2009
    ..abstract_text> ..
  8. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..