hh

Summary

Gene Symbol: hh
Description: hedgehog
Alias: CG4637, Dmel\CG4637, Mir, Mrt, anon-WO0134654.19, anon-WO0182946.19, bar, bar-3, bar3, l(3)hh, l(3)neo56, l(3)neo57, CG4637 gene product from transcript CG4637-RB, CG4637-PB, PKC, atypical, bar-on-3, hedghog, hh-PB, mirabile, moonrat
Species: fruit fly

Top Publications

  1. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
  2. ncbi Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    T Tabata
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Cell 76:89-102. 1994
  3. ncbi decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
    T Xie
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Cell 94:251-60. 1998
  4. ncbi Hedgehog regulates smoothened activity by inducing a conformational switch
    Yun Zhao
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 450:252-8. 2007
  5. ncbi Autoproteolysis in hedgehog protein biogenesis
    J J Lee
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD 21205
    Science 266:1528-37. 1994
  6. pmc Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
    Shuofei Cheng
    Institut de Recherches Cliniques de Montreal, 110 Pine Avenue West, Montreal, QC H2W1R7, Canada
    Dev Biol 337:99-109. 2010
  7. ncbi Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    N Denef
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 102:521-31. 2000
  8. ncbi wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis
    M K Baylies
    Development 121:3829-37. 1995
  9. ncbi Distinct roles of Central missing and Dispatched in sending the Hedgehog signal
    K Amanai
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Development 128:5119-27. 2001
  10. ncbi Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    Jianhang Jia
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Nature 416:548-52. 2002

Research Grants

Patents

  1. INTEGRATIVE RECOMBINANT ADENOVIRUSES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF

Detail Information

Publications200 found, 100 shown here

  1. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
    ....
  2. ncbi Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
    T Tabata
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143
    Cell 76:89-102. 1994
    ..We propose that the cell-cell communication mediated by hedgehog links the special properties of compartment borders with specification of the proximodistal axis in imaginal development...
  3. ncbi decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
    T Xie
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Cell 94:251-60. 1998
    ..We constructed mutant germline stem cell clones to show that the dpp signal is directly received by germline stem cells. Thus, dpp signaling helps define a niche that controls germline stem cell proliferation...
  4. ncbi Hedgehog regulates smoothened activity by inducing a conformational switch
    Yun Zhao
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 450:252-8. 2007
    Hedgehog (HH) morphogen is essential for metazoan development. The seven-transmembrane protein smoothened (SMO) transduces the HH signal across the plasma membrane, but how SMO is activated remains poorly understood...
  5. ncbi Autoproteolysis in hedgehog protein biogenesis
    J J Lee
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD 21205
    Science 266:1528-37. 1994
    Extracellular signaling proteins encoded by the hedgehog (hh) multigene family are responsible for the patterning of a variety of embryonic structures in vertebrates and invertebrates...
  6. pmc Regulation of smoothened by Drosophila G-protein-coupled receptor kinases
    Shuofei Cheng
    Institut de Recherches Cliniques de Montreal, 110 Pine Avenue West, Montreal, QC H2W1R7, Canada
    Dev Biol 337:99-109. 2010
    The Hedgehog (Hh) signaling pathway plays a conserved and essential role in regulating development and homeostasis of numerous tissues...
  7. ncbi Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    N Denef
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 102:521-31. 2000
    ..Comparable effects can be produced by removing Patched from cells by RNA-mediated interference. These findings raise the possibility that Patched acts indirectly to regulate Smoothened activity...
  8. ncbi wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis
    M K Baylies
    Development 121:3829-37. 1995
    ..Moreover, we present evidence that Wg can signal across germ layers and that, in the wild-type embryo, Wg from the ectoderm could constitute an inductive signal for the initiation of the development of a subset of somatic muscles...
  9. ncbi Distinct roles of Central missing and Dispatched in sending the Hedgehog signal
    K Amanai
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Development 128:5119-27. 2001
    Secreted Hedgehog (Hh) proteins control many aspects of growth and patterning in animal development. The mechanism by which the Hh signal is sent and transduced is still not well understood...
  10. ncbi Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    Jianhang Jia
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Nature 416:548-52. 2002
    ..Here we show that Sgg is also a negative regulator in the Hedgehog (Hh) pathway...
  11. ncbi The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    D M Stone
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 384:129-34. 1996
    ..These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc...
  12. ncbi A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
    M Strigini
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 124:4697-705. 1997
    The secreted protein Hedgehog (Hh) transmits a signal from posterior to anterior cells that is essential for limb development in insects and vertebrates...
  13. ncbi Notch signalling and the initiation of neural development in the Drosophila eye
    A Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 128:3889-98. 2001
    ..Both Dpp and the second signal are dependent on Hedgehog (Hh) signalling...
  14. ncbi The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster
    Reka Albert
    School of Mathematics, University of Minnesota, 127 Vincent Hall, Minneapolis, MN 55455, USA
    J Theor Biol 223:1-18. 2003
    ..The model gives important insights into the functioning of the segment polarity gene network, such as the crucial role of the wingless and sloppy paired genes, and the network's ability to correct errors in the pre-pattern...
  15. pmc Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Genes Dev 17:2709-20. 2003
    The Hedgehog (Hh) family of secreted proteins controls many aspects of growth and patterning in animal development...
  16. ncbi Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
    Lawrence Lum
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Mol Cell 12:1261-74. 2003
    ..evidence that Smo associates directly with a Ci-containing complex that is scaffolded and stabilized by the atypical kinesin, Costal-2 (Cos2)...
  17. ncbi Lipoprotein-heparan sulfate interactions in the Hh pathway
    Christina Eugster
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Cell 13:57-71. 2007
    ..They further suggest that the complement of proteins present on lipoprotein particles can regulate the activity of morphogens...
  18. pmc Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila
    Vladimir L Katanaev
    Department of Biology, TransRegio SFB11, University of Konstanz, Konstanz, Germany
    EMBO J 27:509-21. 2008
    ..In its action reggie-1 appears specific for Wnt and Hedgehog. These data suggest that reggie-1 is an important component of the Wnt and Hedgehog secretion pathway dedicated to formation of the mobile pool of these morphogens...
  19. pmc G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
    Stacey K Ogden
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Nature 456:967-70. 2008
    The hedgehog (Hh) signalling pathway has an evolutionarily conserved role in patterning fields of cells during metazoan development, and is inappropriately activated in cancer...
  20. doi Increased cell bond tension governs cell sorting at the Drosophila anteroposterior compartment boundary
    Katharina P Landsberg
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Biol 19:1950-5. 2009
    ..Our results provide a physical mechanism in which the local increase in Myosin II-dependent cell bond tension directs cell sorting at compartment boundaries...
  21. ncbi Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
    Sergey Apionishev
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Nat Cell Biol 7:86-92. 2005
    The Hedgehog (Hh) signalling pathway is crucial for animal development and is aberrantly activated in several types of cancer...
  22. ncbi Cholesterol modification of hedgehog signaling proteins in animal development
    J A Porter
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Science 274:255-9. 1996
    Hedgehog (Hh) proteins comprise a family of secreted signaling molecules essential for patterning a variety of structures in animal embryogenesis...
  23. ncbi Dual roles for patched in sequestering and transducing Hedgehog
    Y Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 87:553-63. 1996
    Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor...
  24. pmc Transducing Hedgehog: the story so far
    P W Ingham
    Developmental Genetics Programme, The Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK
    EMBO J 17:3505-11. 1998
    ..Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease...
  25. doi Nanoscale organization of hedgehog is essential for long-range signaling
    Neha Vyas
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560 065, India
    Cell 133:1214-27. 2008
    Hedgehog (Hh) plays crucial roles in tissue-patterning and activates signaling in Patched (Ptc)-expressing cells...
  26. ncbi The sterol-sensing domain: multiple families, a unique role?
    Patricia E Kuwabara
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Trends Genet 18:193-201. 2002
    ..This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis...
  27. ncbi Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
    P W Ingham
    Molecular Embryology Laboratory, Imperial Cancer Research Fund, London, UK
    Curr Biol 5:432-40. 1995
    Members of the hedgehog (hh) gene family encode a novel class of proteins implicated in positional signalling in both invertebrates and vertebrates...
  28. ncbi smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
    M van den Heuvel
    Molecular Embryology Laboratory, Imperial Cancer Research Fund, London, UK
    Nature 382:547-51. 1996
    ..This structure is typical of G-protein-coupled receptors, suggesting that the Smoothened protein may act as a receptor for the Hedgehog ligand...
  29. ncbi Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila
    Madhuri Kango-Singh
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 129:5719-30. 2002
    ..shar-pei encodes a WW-domain-containing protein that has homologs in worms, mice and humans, suggesting that mechanisms of organ growth control are evolutionarily conserved...
  30. ncbi Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
    Carlos Torroja
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 131:2395-408. 2004
    The Hedgehog (Hh) morphogenetic gradient controls multiple developmental patterning events in Drosophila and vertebrates. Patched (Ptc), the Hh receptor, restrains both Hh spreading and Hh signaling...
  31. ncbi Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 432:1045-50. 2004
    The Hedgehog (Hh) family of secreted proteins governs cell growth and patterning in animal development...
  32. ncbi Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog
    Satomi Takeo
    Department of Biology, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
    Dev Biol 284:204-18. 2005
    ..defects as well as a substantial overgrowth of tissues and animals through the expansion of the action range of Hh. These findings support the recently proposed model that secreted glypicans have opposing and/or distinct effects on ..
  33. ncbi Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused
    Sandra Claret
    Laboratoire Génétique du Développement et Evolution, Institut Jacques Monod, Universite Paris 7, Unite Mixte de Recherche 7592, Centre National de la Recherche Scientifique, Universités Paris 6 and 7, 2 Place Jussieu 75251 Paris, France
    Curr Biol 17:1326-33. 2007
    Hedgehog (HH) is a major secreted morphogen involved in development, stem cell maintenance and oncogenesis [1, 2]...
  34. doi Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate
    J Andrew Pospisilik
    Institute of Molecular Biotechnology of the Austrian Academy of Science, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 140:148-60. 2010
    ..These findings identify a role for hedgehog signaling in white/brown adipocyte determination and link in vivo RNAi-based scanning of the Drosophila genome to regulation of adipocyte cell fate in mammals...
  35. pmc G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
    Yongbin Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Genes Dev 24:2054-67. 2010
    G protein-coupled receptor kinase 2 (Gprk2/GRK2) plays a conserved role in modulating Hedgehog (Hh) pathway activity, but its mechanism of action remains unknown...
  36. pmc Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus
    Hongge Jia
    Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 285:37218-26. 2010
    ..In this study, we demonstrate that CK2 is a positive regulator of the Hedgehog (Hh) signal transduction pathway...
  37. pmc Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling
    Cristina Molnar
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain
    PLoS Genet 7:e1001335. 2011
    ....
  38. ncbi A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci
    Ping Dai
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Dev Cell 4:917-28. 2003
    Transcription factor Ci mediates Hedgehog (Hh) signaling to determine the anterior/posterior (A/P) compartment of Drosophila wing disc...
  39. ncbi The role of segment polarity genes during Drosophila neurogenesis
    N H Patel
    Howard Hughes Medical Institute, Department of Biochemistry, University of California Berkeley 94720
    Genes Dev 3:890-904. 1989
    ..Thus, in addition to their functions in epidermal pattern formation, at least four of the segment polarity genes (gooseberry, patched, Cell, and wingless) appear to have specific roles in the control of cell fates during neurogenesis...
  40. ncbi hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila
    A J Forbes
    Molecular Embryology Laboratory, Imperial Cancer Research Fund, Developmental Biology Unit, Department of Zoology, Oxford, UK
    Development 122:1125-35. 1996
    The hedgehog (hh) gene plays a role in regulating cell proliferation and specifying cell identity in diverse systems...
  41. ncbi Dual role for Hedgehog in the regulation of the proneural gene atonal during ommatidia development
    M Dominguez
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 126:2345-53. 1999
    ..The two temporal responses to Hedgehog are due to direct stimulation of the responding cells by Hedgehog itself...
  42. ncbi The hedgehog morphogen and gradients of cell affinity in the abdomen of Drosophila
    P A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 126:2441-9. 1999
    ..Within the P compartment we found some evidence for a U-shaped gradient of affinity, but this cannot be due to Hedgehog which does not act in the P compartment...
  43. pmc Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation
    Margery G Smelkinson
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 13:481-95. 2007
    ..Here we show that multiple successively phosphorylated CK1 sites on Ci create an atypical extended binding site for the SCF substrate recognition component Slimb...
  44. ncbi Identification of functional sine oculis motifs in the autoregulatory element of its own gene, in the eyeless enhancer and in the signalling gene hedgehog
    Tobias Pauli
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Development 132:2771-82. 2005
    ..Our results strengthen the general assumption that feedback loops among the genes of the retinal determination network are crucial for proper development of eyes and ocelli...
  45. ncbi Pointed regulates an eye-specific transcriptional enhancer in the Drosophila hedgehog gene, which is required for the movement of the morphogenetic furrow
    Edward M Rogers
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 132:4833-43. 2005
    ..We report that the mechanism that underlies this difference is the special regulation of hedgehog (hh) transcription through the dual regulation of an eye specific enhancer...
  46. ncbi Notch signaling controls germline stem cell niche formation in the Drosophila ovary
    Xiaoqing Song
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 134:1071-80. 2007
    ..Our results indicate that Notch signaling is important for formation and maintenance of the GSC niche, and that cap cells help determine niche size and function...
  47. pmc The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
    Cristina Molnar
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 104:7963-8. 2007
    ..Interestingly, the expression of Gprk2 in the wing disc is regulated in part by Smo, generating a positive feedback loop that maintains high Smo activity close to the anterior-posterior compartment boundary...
  48. pmc Sequential phosphorylation of smoothened transduces graded hedgehog signaling
    Ying Su
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Sci Signal 4:ra43. 2011
    The correct interpretation of a gradient of the morphogen Hedgehog (Hh) during development requires phosphorylation of the Hh signaling activator Smoothened (Smo); however, the molecular mechanism by which Smo transduces graded Hh ..
  49. ncbi Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
    J A Porter
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Cell 86:21-34. 1996
    Autocatalytic processing mediated by the carboxyterminal domain of the hedgehog (hh) protein precursor (Hh) generates an amino-terminal product that accounts for all known signaling activity...
  50. ncbi Transducing the hedgehog signal
    D Kalderon
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Cell 103:371-4. 2000
  51. ncbi Hedgehog signaling in vertebrate and invertebrate limb patterning
    J Capdevila
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla California 92037 1099, USA
    Cell Mol Life Sci 57:1682-94. 2000
    ..Here we highlight the similarities and differences between the use of Hedgehog signaling in these two systems...
  52. ncbi Evolution in black and white: genetic control of pigment patterns in Drosophila
    Patricia J Wittkopp
    Molecular Biology and Genetics, 227 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Trends Genet 19:495-504. 2003
  53. pmc The full-length unprocessed hedgehog protein is an active signaling molecule
    Robert Tokhunts
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 285:2562-8. 2010
    The hedgehog (HH) family of ligands plays an important instructional role in metazoan development...
  54. pmc Genetic and biochemical definition of the Hedgehog receptor
    Xiaoyan Zheng
    Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 24:57-71. 2010
    ..the transporter-like protein Patched (Ptc) is genetically implicated in reception of the extracellular Hedgehog (Hh) protein signal, a clear definition of the Hh receptor is complicated by the existence of additional Hh-binding ..
  55. pmc The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development
    Dong Yan
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, and The Graduate Program in Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 137:2033-44. 2010
    Hedgehog (Hh) acts as a morphogen in various developmental contexts to specify distinct cell fates in a concentration-dependent manner...
  56. pmc Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium
    Ainhoa Callejo
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 108:12591-8. 2011
    Hedgehog (Hh) moves from the producing cells to regulate the growth and development of distant cells in a variety of tissues...
  57. ncbi The combgap locus encodes a zinc-finger protein that regulates cubitus interruptus during limb development in Drosophila melanogaster
    P C Svendsen
    Department of Biochemistry and Molecular Biology, and Genes and Development Research Group, Faculty of Medicine, University of Calgary, Calgary Alberta, T2N 4N1, Canada
    Development 127:4083-93. 2000
    ..Finally, we find that the combgap protein binds to polytene chromosomes at many sites including the cubitus interruptus locus, suggesting that it could be a direct regulator of cubitus interruptus transcription...
  58. ncbi Divide and conquer: pattern formation in Drosophila embryonic epidermis
    V Hatini
    Dept Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Genet 17:574-9. 2001
    ..Here, we review several recent reports that help to elucidate the regulatory principles used to control this pattern. Because organizers are conserved, the same fundamental principles might operate in other organizers...
  59. ncbi Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
    Wensheng Zhang
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Dev Cell 8:267-78. 2005
    Hedgehog (Hh) proteins control animal development by regulating the Gli/Ci family of transcription factors...
  60. ncbi Serrate-Notch signaling defines the scope of the initial denticle field by modulating EGFR activation
    James W Walters
    Weill Graduate School of Medical Sciences, New York, NY 10021, USA
    Dev Biol 286:415-26. 2005
    ..This establishes one important role for the Serrate signaling territory, which is to define the extent of denticle field specification...
  61. doi Hedgehog-dependent down-regulation of the tumor suppressor, vitamin D3 up-regulated protein 1 (VDUP1), precedes lamina development in Drosophila
    Solomon Chang
    Albany College of Pharmacy and Health Sciences, Department of Pharmaceutical Sciences, 9 Samaritan Road, Albany, NY 12208, USA
    Brain Res 1324:1-13. 2010
    ..Hedgehog (Hh) is a signal well known to coordinate LPC proliferation and differentiation in response to retinal axon innervation, ..
  62. ncbi Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched
    A Hidalgo
    Molecular Embryology Laboratory, ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK
    Development 110:291-301. 1990
    ..Furthermore, the products of engrailed, wingless and hedgehog are essential for maintaining the normal pattern of expression of patched...
  63. ncbi A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog
    T M Hall
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 378:212-6. 1995
    Within the past few years, members of the hedgehog (hh) family of secreted signalling proteins have emerged as the primary signals generated by certain embryonic patterning centres...
  64. ncbi The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways
    C K Motzny
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Mech Dev 52:137-50. 1995
    ..The role of ci in cell-cell signaling and pattern formation was examined in double mutants of ci with patched and zeste-white3/shaggy...
  65. ncbi Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning
    T Lepage
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Nature 373:711-5. 1995
    ..Localized expression of the secreted Hedgehog protein (Hh) by cells in the posterior compartment induces expression of the secreted signalling molecules decapentaplegic (dpp) ..
  66. ncbi Protein kinase A and hedgehog signaling in Drosophila limb development
    J Jiang
    Howard Hughes Medical Institute, Department of Genetics and Development Columbia University College of Physicians and Surgeons, New York, New York 10032
    Cell 80:563-72. 1995
    The Drosophila hedgehog (hh) gene encodes a secreted protein involved in organizing growth and patterning in many developmental processes...
  67. pmc Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings
    J Capdevila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Spain
    EMBO J 13:4459-68. 1994
    ..We also show that ectopic expression of the segment polarity gene hedgehog (hh) gives similar morphological changes and activates dpp expression in the anterior compartment...
  68. ncbi wingless inhibits morphogenetic furrow movement in the Drosophila eye disc
    J E Treisman
    Department of Molecular and Cell Biology, UC Berkeley 94720, USA
    Development 121:3519-27. 1995
    ..In addition, the presence of wingless in the center of the disc can prevent furrow progression. These effects of wingless are achieved without altering the expression of decapentaplegic...
  69. ncbi Induction of Drosophila eye development by decapentaplegic
    F Pignoni
    Howard Hughes Medical Institute, The School of Medicine, University of California, Los Angeles 90095, USA
    Development 124:271-8. 1997
    ..In addition, Dpp positively controls its own expression and suppresses wingless transcription. In contrast to the wing disc, Dpp does not appear to be the principal mediator of Hedgehog function in the eye...
  70. ncbi Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
    P Aza-Blanc
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
    Cell 89:1043-53. 1997
    Cell-cell communication at anterior/posterior compartment borders in Drosophila involves Hedgehog (Hh), a protein secreted by posterior cells, and Cubitus interruptus (Ci), a protein in the Hh response pathway in anterior cells...
  71. ncbi Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
    D J Robbins
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, 94143 0552, USA
    Cell 90:225-34. 1997
    The hedgehog gene of Drosophila melanogaster encodes a secreted protein (HH) that plays a vital role in cell fate and patterning. Here we describe a protein complex that mediates signal transduction from HH...
  72. ncbi decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc
    D J Hazelett
    Skirball Institute for Biomolecular Medicine and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA
    Development 125:3741-51. 1998
    ..These results provide a link between the early specification and later differentiation of the eye disc...
  73. ncbi Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains
    A Rietveld
    Cell Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    J Biol Chem 274:12049-54. 1999
    ..They further suggest sterol modification as a novel mechanism for targeting proteins to raft membranes and raise the possibility that signaling and polarized intracellular transport of Hedgehog are based on raft association...
  74. ncbi The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing
    M Vervoort
    Centre de Biologie du Développement UMR 5547 CNRS UPS 118 route de Narbonne, 31062, Toulouse Cedex, France
    Curr Biol 9:632-9. 1999
    The secreted Hedgehog (Hh) proteins have been implicated as mediators of positional information in vertebrates and invertebrates. A gradient of Hh activity contributes to antero-posterior (A/P) patterning of the fly wing...
  75. ncbi Engrailed and hedgehog make the range of Wingless asymmetric in Drosophila embryos
    B Sanson
    Department of Genetics, Cambridge University, United Kingdom
    Cell 98:207-16. 1999
    ..We demonstrate the role of hedgehog in the formation of this barrier...
  76. ncbi Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
    C H Chen
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 98:305-16. 1999
    Transcriptional activation of Hedgehog (Hh) target genes requires Cubitus interruptus, a 155 kDa cytoplasmic zinc finger protein (Ci155), which in the absence of Hh signaling is processed to form a nuclear repressor (Ci75)...
  77. ncbi Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs
    H Tanimoto
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Mol Cell 5:59-71. 2000
    Hedgehog (HH) and Decapentaplegic (DPP) direct anteroposterior patterning in the developing Drosophila wing by functioning as short- and long-range morphogens, respectively...
  78. ncbi Identification of a tetrameric hedgehog signaling complex
    M A Stegman
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 275:21809-12. 2000
    Hedgehog (Hh) signal transduction requires a large cytoplasmic multi-protein complex that binds microtubules in an Hh-dependent manner...
  79. pmc Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
    G Wang
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Genes Dev 14:2893-905. 2000
    The Hedgehog (Hh) family of secreted proteins controls many aspects of growth and patterning in animal development...
  80. ncbi An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development
    J D Lee
    Skirball Institute Developmental Genetics Program, Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Dev Biol 233:122-36. 2001
    ..Furthermore, overexpression of the mutant form has dominant negative effects on Hedgehog signaling. These data suggest that the importance of the N-terminal cysteine of mature Hedgehog in patterning appendages differs between species...
  81. ncbi Mechanisms of size control
    C J Potter
    Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536 0812, USA
    Curr Opin Genet Dev 11:279-86. 2001
    ..The mechanisms of organ size control could also be critical targets for evolutionary events or disease processes such as tumorigenesis...
  82. ncbi Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal
    Z Chamoun
    Institut für Molekularbiologie and Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Science 293:2080-4. 2001
    One of the most dominant influences in the patterning of multicellular embryos is exerted by the Hedgehog (Hh) family of secreted signaling proteins...
  83. ncbi Successive specification of Drosophila neuroblasts NB 6-4 and NB 7-3 depends on interaction of the segment polarity genes wingless, gooseberry and naked cuticle
    N Deshpande
    Institut fur Genetik, Universitat Mainz, Saarstrasse 21, D 55122 Mainz, Germany
    Development 128:3253-61. 2001
    ..In the absence of either nkd or gsb, one NB fate is replaced by the other. However, the temporal sequence of delamination is maintained, suggesting that formation and specification of these two NBs are under independent control...
  84. ncbi Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E
    Molly Duman-Scheel
    Ben May Institute for Cancer Research and Center for Molecular Oncology, The University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    Nature 417:299-304. 2002
    Although mutations that activate the Hedgehog (Hh) signalling pathway have been linked to several types of cancer, the molecular and cellular basis of Hh's ability to induce tumour formation is not well understood...
  85. ncbi Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division
    Youngji Park
    Department of Biochemistry and Biophysics, Texas A and M University, TAMU 2128, College Station, TX 77843 2128, USA
    Dev Biol 253:247-57. 2003
    ..that trol encodes the Drosophila homolog of Perlecan and regulates neuroblast division by modulating both FGF and Hh signaling...
  86. ncbi Mechanism of hedgehog signaling during Drosophila eye development
    Kartik S Pappu
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 130:3053-62. 2003
    Although Hedgehog (Hh) signaling is essential for morphogenesis of the Drosophila eye, its exact link to the network of tissue-specific genes that regulate retinal determination has remained elusive...
  87. ncbi Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development
    Weimin Fu
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 130:5229-39. 2003
    ..Hedgehog (Hh), Decapentaplegic (Dpp) and Notch (N) signaling all contribute...
  88. ncbi Self-enhanced ligand degradation underlies robustness of morphogen gradients
    Avigdor Eldar
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Cell 5:635-46. 2003
    ..The two robust networks are consistent with properties of the Wg and Hh morphogens in the Drosophila wing disc and provide novel insights into their function.
  89. ncbi Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenance
    Lisa Maves
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403 1254, USA
    Curr Opin Genet Dev 13:472-9. 2003
    ..An important future goal is to address how signaling pathways interact with chromatin structure to regulate and maintain the proper expression of selector genes...
  90. ncbi Three Drosophila EXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans
    Yuki Takei
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Development 131:73-82. 2004
    The signaling molecules Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg) function as morphogens and organize wing patterning in Drosophila...
  91. ncbi The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog
    Nicole Gorfinkiel
    Centro de Biologia Molecular, Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Dev Cell 8:241-53. 2005
    The Hedgehog (Hh) family of morphogenetic proteins has important instructional roles in metazoan development and human diseases...
  92. ncbi Lipoprotein particles are required for Hedgehog and Wingless signalling
    Daniela Panàkovà
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Nature 435:58-65. 2005
    ..Similarly, the range of Wingless signalling is narrowed. We propose a novel function for lipoprotein particles, in which they act as vehicles for the movement of lipid-linked morphogens and glycophosphatidylinositol-linked proteins...
  93. ncbi Role of the Drosophila patched gene in positional signalling
    P W Ingham
    ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK
    Nature 353:184-7. 1991
    ..We suggest that the patched protein may itself be the receptor for this signal, implying that this is an unusual mechanism of ligand-dependent receptor inactivation...
  94. pmc Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila
    J Mohler
    Department of Biological Sciences, Barnard College, New York, New York 10027
    Genetics 120:1061-72. 1988
    ..Because the defects are associated with homozygous clones, but are not co-extensive, a type of "domineering" nonautonomy is proposed for the activity of the hedgehog gene...
  95. pmc Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis
    S DiNardo
    Department of Biochemistry and Biophysics, UCSF School of Medicine 94143 0448
    Nature 332:604-9. 1988
    ..This late programme maintains and perhaps modifies the striped pattern of engrailed expression through interactions that may involve cell communication...
  96. ncbi Multiple functions of segment polarity genes in Drosophila
    N Perrimon
    Dev Biol 119:587-600. 1987
    ..The respective maternal and zygotic contribution and the roles of the segment polarity loci for the patterning of the embryo and the adult are discussed...
  97. ncbi scratch, a pan-neural gene encoding a zinc finger protein related to snail, promotes neuronal development
    M Roark
    Biological Sciences Program, California State University, San Marcos 92096, USA
    Genes Dev 9:2384-98. 1995
    ..We discuss the similarities between the roles of the ancestrally related scrt, sna, and escargot (esc) genes in regulating cell fate choices...
  98. ncbi The function of engrailed and the specification of Drosophila wing pattern
    I Guillen
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Spain
    Development 121:3447-56. 1995
    ..The en-expressing cells in the anterior compartment also induce high levels of the hedgehog (hh) and decapentaplegic (dpp) gene products, which results in local duplications of anterior patterns...
  99. ncbi cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
    D Pan
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200
    Cell 80:543-52. 1995
    ..Our findings suggest that PKA is a component of a signaling pathway that represses dpp expression and that hh antagonizes this pathway to maintain dpp expression at the anterior-posterior compartment border and in the ..
  100. ncbi Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development
    W Li
    Department of Biological Sciences, Columbia University, New York, New York 10027
    Cell 80:553-62. 1995
    ..induction of decapentaplegic (dpp), wingless (wg), and patched (ptc) transcription that is independent of hedgehog (hh) gene activity...
  101. ncbi dishevelled and armadillo act in the wingless signalling pathway in Drosophila
    J Noordermeer
    Howard Hughes Medical Institute, California
    Nature 367:80-3. 1994
    ..We show that wingless acts through dishevelled and armadillo to affect the expression of the homeobox gene engrailed and cuticle differentiation...

Research Grants47

  1. Mechanisms governing polarity in Drosophila oogenesis
    Daniel Kalderon; Fiscal Year: 2004
    ....
  2. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. [unreadable] [unreadable]..
  3. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
  4. Identification of extrinsic signals in blood formation
    Jan Christian; Fiscal Year: 2006
    ..Understanding how normal blood development occurs is crucial to understanding and preventing disease resulting from misregulation of these pathways. ..
  5. Molecular Analysis of Visual Plasticity
    Samuel Kunes; Fiscal Year: 2006
    ..abstract_text> ..
  6. Analysis of Early Wing Vein Development in Drosophila
    Ethan Bier; Fiscal Year: 2007
    ..Thus, knowledge gained from these studies should have broad applications to understanding vertebrate development as well as offering possible insights into mechanisms of human disease. ..
  7. High-throughput screening assay development for axonopathic neurodegeration
    Norbert Perrimon; Fiscal Year: 2006
    ..The long term goal of this work is thus to understand better the causes of axonal destruction in neurodegenerative diseases, and to find drugs that can slow or prevent axonal degeneration from occurring. ..
  8. Viral Immunity in Drosophila
    Norbert Perrimon; Fiscal Year: 2007
    ..Because our insect virus system is sensitive to drugs that are used against human viruses, our studies may lead to the identification of novel antiviral compounds that may prove effective in mammalian cells. ..
  9. Analysis of BMP-4 activity in Cleavage mutant mice
    Jan Christian; Fiscal Year: 2007
    ..Understanding the molecular mechanisms by which BMP activity is regulated is key to understanding, treating and preventing congenital anomalies and diseases. [unreadable] [unreadable]..
  10. TRAINING PROGRAM IN CELLULAR AND MOLECULAR NEUROSCIENCE
    ARTHUR LANDER; Fiscal Year: 2007
    ..Following completion of this program, trainees will be qualified for careers in Neuroscience research and/or teaching in basic science departments and medical schools, or for research careers in non-academic research laboratories. ..
  11. A novel Dlg isoform and identification of its interacting proteins
    Kyung Ok Cho; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Mechanism of Hedgehog signal transduction
    JOAN HOOPER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Signaling by Hedgehog (Hh) family members mediate local cell-cell communication that is essential for development and maintenance of many tissues and structures...
  13. Synaptic Structural Plasticity in the Drosophila Brain
    Samuel Kunes; Fiscal Year: 2007
    ..By understanding what molecules may regulate synaptic dynamics in a normal CNS, we may be able to induce specific changes in a brain damaged by disease or stroke, or that malfunctions in behavioral disorders. [unreadable] [unreadable]..
  14. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
    ..Since the machinery for Wnt signal transduction is also evolutionarily conserved, understanding tissue specific mechanisms of Wg signaling in flies should have broad relevance to other organisms. ..
  15. Network Topology in Cell Signaling
    Norbert Perrimon; Fiscal Year: 2008
    ..Altogether, these studies will greatly advance our knowledge of signaling networks and their organization during signal transduction. [unreadable] [unreadable] [unreadable]..
  16. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  17. Host factors involved in bacterial pathogenesis
    Norbert Perrimon; Fiscal Year: 2009
    ..tuberculosis and its human host. ..
  18. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  19. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
    ..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
  20. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
  21. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  22. MOLECULAR GENETICS OF EARLY NEUROGENESIS
    Ethan Bier; Fiscal Year: 2010
    ..These studies may provide the framework for our future studies relevant to human disease and drug abuse. ..
  23. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
  24. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas E Baker; Fiscal Year: 2010
    ....
  25. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
    ..Further, these in vivo studies may help in understanding the basis of some dysmorphologies in humans. ..
  26. GORDON RESEARCH CONFERENCE ON PROTEOGLYCANS
    ARTHUR LANDER; Fiscal Year: 2002
    ....
  27. MOLECULAR MECHANISM OF WINGLESS SIGNALING
    Susan Cumberledge; Fiscal Year: 2002
    ....
  28. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
    ..We will also determine how the virally encoded Tax protein allows CREB to recognize the atypical CREs in the HTLV-1 promoter by characterizing the structure of the Tax: CREB : HTLV-1 DNA complex...
  29. ROLES OF HEPARAN SULFATE PROTEOGLYCANS IN SIGNALING
    Norbert Perrimon; Fiscal Year: 2003
    ..GAG chains, exhibit phenotypes reminiscent of loss of Wingless (Wg), Fibroblast Growth Factor (FGF) and/or Hedgehog (Hh) activities...
  30. ANALYSIS OF NEUROFIBROMATOSIS TYPE 1 GENE FUNCTION
    Andre Bernards; Fiscal Year: 2003
    ..These studies will help us understand the normal function of the NF1 gene in vivo and will contribute to our understanding of the diverse manifestations of the disease process. ..
  31. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  32. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2004
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  33. Cell Cycle and Development
    BRUCE EDGAR; Fiscal Year: 2004
    ....
  34. Transport and Complexity in Biological Systems
    ARTHUR LANDER; Fiscal Year: 2004
    ..abstract_text> ..
  35. High-throughput screen:Listeria infection (RMI)
    Norbert Perrimon; Fiscal Year: 2004
    ....
  36. Conference on Cell Polarity & Asymmetric Cell Divisions
    Norbert Perrimon; Fiscal Year: 2004
    ..The goal of the meeting is to bring together the leading experts that study the mechanism of cell polarization and cell asymmetry to discuss emerging concepts. ..
  37. Molecular Genetics of Drosophila MAGUK's
    Peter Bryant; Fiscal Year: 2005
    ..The work will provide a genetic approach to understanding the functions of Dlg and its mammalian homologs, some of which are strongly implicated in a variety of human cancers. ..
  38. MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS
    J Marsh; Fiscal Year: 2005
    ..Finally, we have identified a collection of mutants affecting disc growth patterns that serve as an enriched collection of new candidate genes to participate in these events. ..
  39. Genetic Analysis of Bacterial Toxins in Drosophia
    Ethan Bier; Fiscal Year: 2005
    ..DN alleles 2-2: Characterize molecular lesion in DN-toxin NOVA alleles 2-3: Confirm that DN-toxin alleles interfere with wild-type toxin gene function 2-4: Determine whether DN-toxin alleles function in mammalian cells ..
  40. Axon Guidance in the Visual Systems of Drosophila
    Samuel Kunes; Fiscal Year: 2005
    ....
  41. Hedgehog Signaling and Sex-lethal Protein Localization
    JAMILA HORABIN; Fiscal Year: 2004
    ..Recently, we have shown that the female germ line stem cells and early cystoblasts use the Hedgehog(hh) signaling pathway to regulate the trafficking of Sxl into the nucleus and its degradation...
  42. Organogenesis Screen Using Tissue-Specific Zebrafish
    Jau Nian Chen; Fiscal Year: 2005
    ..Mutations identified from this screen will provide entry points to dissect genetic and molecular pathways involved in vertebrate organogenesis. ..
  43. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
    ..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
  44. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  45. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  46. SPECTRAL CONFOCAL MICROSCOPE
    Peter Bryant; Fiscal Year: 2002
    ..abstract_text> ..

Patents1

  1. INTEGRATIVE RECOMBINANT ADENOVIRUSES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF
    Patent Number: WO9523867-A1; Date:1995-09-08