hb

Summary

Gene Symbol: hb
Description: hunchback
Alias: CG9786, Dmel\CG9786, Hunchback, R-pbx, Rg-bx, Rg-pbx, hbHLH, l(3)85Ah, CG9786 gene product from transcript CG9786-RA, CG9786-PA, CG9786-PB, Regulator-of-postbithorax, hb-PA, hb-PB
Species: fruit fly

Top Publications

  1. ncbi A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
    D Tautz
    Institut fur Genetik, Mikrobiologie der Universität München, Federal Republic of Germany
    Chromosoma 98:81-5. 1989
  2. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
  3. pmc Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors
    - Manu
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Comput Biol 5:e1000303. 2009
  4. pmc Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila species
    Robert K Bradley
    Department of Mathematics, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 8:e1000343. 2010
  5. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
  6. pmc A conserved developmental patterning network produces quantitatively different output in multiple species of Drosophila
    Charless C Fowlkes
    Department of Computer Science, University of California Irvine, Irvine, California, USA
    PLoS Genet 7:e1002346. 2011
  7. pmc Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS
    R Kambadur
    The Neurogenetics Unit, Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892 USA
    Genes Dev 12:246-60. 1998
  8. ncbi Role of spatial averaging in the precision of gene expression patterns
    Thorsten Erdmann
    FOM Institute for Atomic and Molecular Physics, Science Park 104, 1098 XG Amsterdam, The Netherlands
    Phys Rev Lett 103:258101. 2009
  9. pmc Gene expression noise in spatial patterning: hunchback promoter structure affects noise amplitude and distribution in Drosophila segmentation
    David M Holloway
    Mathematics Department, British Columbia Institute of Technology, Burnaby, British Columbia, Canada
    PLoS Comput Biol 7:e1001069. 2011
  10. ncbi Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes
    T Gutjahr
    Institute of Molecular Biology II, University of Zurich, Switzerland
    Development 117:609-23. 1993

Detail Information

Publications183 found, 100 shown here

  1. ncbi A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback
    D Tautz
    Institut fur Genetik, Mikrobiologie der Universität München, Federal Republic of Germany
    Chromosoma 98:81-5. 1989
    ..compare the spatial and temporal distribution patterns of the RNA and protein products of the segmentation gene hunchback (hb) during the early stages of embryogenesis...
  2. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
    ....
  3. pmc Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors
    - Manu
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Comput Biol 5:e1000303. 2009
    ..The result confirms the idea that attractors are important for developmental stability and shows a richer variety of dynamical attractors in developmental systems than has been previously recognized...
  4. pmc Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila species
    Robert K Bradley
    Department of Mathematics, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 8:e1000343. 2010
    ....
  5. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
    ..Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function...
  6. pmc A conserved developmental patterning network produces quantitatively different output in multiple species of Drosophila
    Charless C Fowlkes
    Department of Computer Science, University of California Irvine, Irvine, California, USA
    PLoS Genet 7:e1002346. 2011
    ..Our results emphasize that transcriptional networks can diverge over short evolutionary timescales and that even small changes can lead to distinct output in terms of the placement and number of equivalent cells...
  7. pmc Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS
    R Kambadur
    The Neurogenetics Unit, Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892 USA
    Genes Dev 12:246-60. 1998
    ..protein that shares DNA-binding specificity with another pdm repressor: the gap segmentation gene regulator Hunchback (Hb)...
  8. ncbi Role of spatial averaging in the precision of gene expression patterns
    Thorsten Erdmann
    FOM Institute for Atomic and Molecular Physics, Science Park 104, 1098 XG Amsterdam, The Netherlands
    Phys Rev Lett 103:258101. 2009
    ..Balancing these effects yields an optimal diffusion constant maximizing the precision of the expression domain...
  9. pmc Gene expression noise in spatial patterning: hunchback promoter structure affects noise amplitude and distribution in Drosophila segmentation
    David M Holloway
    Mathematics Department, British Columbia Institute of Technology, Burnaby, British Columbia, Canada
    PLoS Comput Biol 7:e1001069. 2011
    ..One of the classic systems for studying this is the activation of the hunchback (hb) gene in early fruit fly (Drosophila) segmentation by the maternally-derived gradient of the Bicoid (Bcd) ..
  10. ncbi Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes
    T Gutjahr
    Institute of Molecular Biology II, University of Zurich, Switzerland
    Development 117:609-23. 1993
    ..mutants even-skipped, runt and hairy, and in all gap mutants suggests that the products of the gap genes hunchback, Krüppel, knirps and giant activate paired expression in stripes...
  11. ncbi Drosophila embryonic pattern repair: how embryos respond to bicoid dosage alteration
    R Namba
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Development 124:1393-403. 1997
    ..We also show that compression of the fate map does not appear to be repaired by the induction of new cell divisions. In addition, some tissues are more sensitive to fate map compression than others...
  12. ncbi Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes
    G Riddihough
    Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK
    Genes Dev 5:840-54. 1991
    ..Our results suggest that different but overlapping subsets of gap genes regulate each stripe and that activation and repression are both important in generating the stripe pattern...
  13. ncbi Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila
    D Stanojevic
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Nature 341:331-5. 1989
    ..The two best characterized gap genes, hunchback (hb) and Krüppel (Kr), contain homologies with the zinc-finger DNA-binding motif, although their mode of action ..
  14. ncbi Evolution of development: beyond bicoid
    Jeremy Lynch
    Department of Biology, New York University, New York, NY 10003, USA
    Curr Biol 13:R557-9. 2003
    ..A new study suggests how this may have evolved out of an alternative mechanism based on cooperating Orthodenticle and Hunchback proteins, the two mechanisms intersecting at the level of downstream target genes.
  15. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006
    ..To model and thoroughly understand animal transcription networks, it is essential to derive accurate spatial and temporal descriptions of developing gene expression patterns with cellular resolution...
  16. doi A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm
    Charless C Fowlkes
    Berkeley Drosophila Transcription Network Project, University of California, Irvine, CA 92697, USA
    Cell 133:364-74. 2008
    ..We present a VirtualEmbryo containing data for 95 genes at six time cohorts. We show that known gene-regulatory interactions can be automatically recovered from this data set and predict hundreds of new interactions...
  17. pmc Gene regulation by MAPK substrate competition
    Yoosik Kim
    Department of Chemical and Biological Engineering, Lewis Sigler Institute for Integrative Genomics, Princeton University, NJ 08544, USA
    Dev Cell 20:880-7. 2011
    ..A mathematical model of this interaction can explain gene expression patterns with both anteroposterior and dorsoventral polarities...
  18. ncbi Dose-dependent regulation of pair-rule stripes by gap proteins and the initiation of segment polarity
    R Warrior
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    Development 110:759-67. 1990
    ..We propose that the relative placement of the eve and hairy stripes may be an important factor in the initiation of segment polarity...
  19. ncbi Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues
    T Goto
    Department of Biochemistry, Harvard University, Cambridge, Massachusetts 02138
    Cell 57:413-22. 1989
    ..As a consequence of this two-step regulatory program, eve functions both in the establishment of the periodic pattern of gene expression and in the subsequent specification of parasegmental boundaries...
  20. ncbi Identical transacting factor requirement for knirps and knirps-related Gene expression in the anterior but not in the posterior region of the Drosophila embryo
    M Rothe
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 46:169-81. 1994
    ....
  21. pmc Probing the limits to positional information
    Thomas Gregor
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA
    Cell 130:153-64. 2007
    ..at their targets (which depends on absolute concentration), the noise in readout of Bicoid by the activation of Hunchback, and the reproducibility of Bicoid concentration at corresponding positions in multiple embryos...
  22. pmc FlyEx, the quantitative atlas on segmentation gene expression at cellular resolution
    Andrei Pisarev
    Department of Computational Biology, St Petersburg State Polytechnical University, St Petersburg 195251, Russia
    Nucleic Acids Res 37:D560-6. 2009
    ..5 h of development. FlyEx supports the data downloads and construction of personal reference datasets, that makes it possible to more effectively use and analyze data...
  23. ncbi Regulation of zygotic gene expression in Drosophila primordial germ cells
    M Van Doren
    Skirball Institute, NYU Medical Center, New York 10016, USA
    Curr Biol 8:243-6. 1998
    ..This expression does not require proper patterning of the soma, indicating that it is likely to be controlled by the germ plasm...
  24. pmc Pre-steady-state decoding of the Bicoid morphogen gradient
    Sven Bergmann
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS Biol 5:e46. 2007
    ..This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage...
  25. ncbi Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells
    P Zuo
    Department of Biological Sciences, Columbia University, New York, New York 10027
    Genes Dev 5:254-64. 1991
    We have studied the ability of the Drosophila gap proteins Krüppel and hunchback to function as transcriptional regulators in cultured cells...
  26. ncbi Targeting gene expression to the head: the Drosophila orthodenticle gene is a direct target of the Bicoid morphogen
    Q Gao
    University of Pennsylvania School of Medicine, Department of Neuroscience, Philadelphia PA 19104, USA
    Development 125:4185-93. 1998
    ..Our study is the first demonstration that a cephalic gap gene is directly regulated by Bcd. However, it also shows that zygotic gene expression can be targeted to the head primordium without direct Bcd regulation...
  27. ncbi Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element
    J S Margolis
    Department of Biology, University of California San Diego, La Jolla 92093 0366, USA
    Development 121:3067-77. 1995
    The gap gene hunchback (hb) is required for the formation and segmentation of two regions of the Drosophila embryo, a broad anterior domain and a narrow posterior domain...
  28. pmc Mechanism and Bicoid-dependent control of hairy stripe 7 expression in the posterior region of the Drosophila embryo
    A La Rosée
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    EMBO J 16:4403-11. 1997
    ..The results suggest that the gradients of Bicoid and Caudal combine their activities to activate segmentation genes along the entire axis of the embryo...
  29. ncbi Nerfin-1 and -2, novel Drosophila Zn-finger transcription factor genes expressed in the developing nervous system
    C Stivers
    The Neurogenetics Unit, Laboratory of Neurochemistry, NINDS, NIH, Bethesda, MD 20892, USA
    Mech Dev 97:205-10. 2000
    ..Possessing a conserved putative DNA-binding domain, the predicted Nerfin-1 and -2 proteins belong to a subfamily of Zn-finger transcription factors with cognates identified in nematode, mouse and man...
  30. ncbi Translational repressors in Drosophila
    Kellie A Dean
    Howard Hughes Medical Institute, Dept of Molecular Genetics and Microbiology, Box 3657, Duke University Medical Center, Durham, NC 27710, USA
    Trends Genet 18:572-7. 2002
    ..These repressors do not work in isolation - each binds multiple sites in the appropriate mRNA, and the resulting RNA-protein complexes appear to recruit co-repressors by a variety of mechanisms...
  31. pmc Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm
    Xiao Yong Li
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Biol 6:e27. 2008
    ....
  32. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  33. pmc Relationship between gene co-expression and sharing of transcription factor binding sites in Drosophila melanogaster
    Antonio Marco
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Arizona State University, Tempe, AZ 85287 5301, USA
    Bioinformatics 25:2473-7. 2009
    ..We have also examined the reverse relationship between the expression correlation and the extent of TFBS sharing...
  34. ncbi Regulation of a segmentation stripe by overlapping activators and repressors in the Drosophila embryo
    D Stanojevic
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    Science 254:1385-7. 1991
    ..Genetic studies suggested that even-skipped (eve) stripe 2 is controlled by three gap genes, hunchback (hb), Kruppel (Kr), and giant (gt), and by the maternal morphogen bicoid (bcd)...
  35. ncbi Characterization of two Drosophila POU domain genes, related to oct-1 and oct-2, and the regulation of their expression patterns
    A Lloyd
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112
    Mech Dev 36:87-102. 1991
    ..This pattern of expression is altered in mutants for a gap gene (hunchback) and a pair-rule gene (fushi tarazu)...
  36. ncbi The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo
    W Driever
    Max Planck Institut fur Entwicklungsbiologie, Abteilung III Genetik, Tubingen, FRG
    Nature 337:138-43. 1989
    ..By binding upstream of the segmentation gene hunchback the bicoid protein controls its transcription, thereby translating maternal pattern-generating information into ..
  37. ncbi Regulation of Drosophila spalt gene expression
    R P Kühnlein
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie Am Fassberg, Gottingen, Germany
    Mech Dev 66:107-18. 1997
    ..In addition, we provide evidence that a zygotic gene product of the terminal system, Tailless, cooperates with the maternal gene product Caudal and thereby activates gene expression in the terminal region of the embryo...
  38. ncbi Establishment of developmental precision and proportions in the early Drosophila embryo
    Bahram Houchmandzadeh
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 415:798-802. 2002
    ..but that this noise in the positional information is strongly decreased ('filtered') at the level of hunchback (hb) gene expression...
  39. ncbi Bicoid determines sharp and precise target gene expression in the Drosophila embryo
    Olivier Crauk
    Laboratory of Nuclear Dynamics and Genome Plasticity, CNRS UMR 218, Institut Curie, Paris, France
    Curr Biol 15:1888-98. 2005
    ..Although the sharpening phenomenon was observed over a decade ago, it is still poorly understood...
  40. ncbi Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen
    W Driever
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, FRG
    Nature 340:363-7. 1989
    ....
  41. ncbi hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryo
    R Lehmann
    Dev Biol 119:402-17. 1987
    The locus hunchback (hb) is a member of the gap class of segmentation genes of Drosophila...
  42. ncbi Mechanism of eve stripe formation
    J Reinitz
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 49:133-58. 1995
    ..Third is the use of least squares fits to gene expression data to measure phenomenological parameters occurring in the gene circuit...
  43. ncbi Rapid evolution of cis-regulatory sequences via local point mutations
    J R Stone
    Department of Ecology and Evolution, State University of New York at Stony Brook, USA
    Mol Biol Evol 18:1764-70. 2001
    ..Even combinations of two new binding sites evolve very quickly. We predict that local point mutations continually generate considerable genetic variation that is capable of altering gene expression...
  44. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II: dynamics
    Soile V E Keränen
    Berkeley Drosophila Transcription Network Project, Genomics Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA
    Genome Biol 7:R124. 2006
    ..To accurately describe gene expression and computationally model animal transcriptional networks, it is essential to determine the changing locations of cells in developing embryos...
  45. pmc Characterization of the Drosophila segment determination morphome
    Svetlana Surkova
    Department of Computational Biology, Center for Advanced Studies, St Petersburg State Polytechnical University, 29 Polytehnicheskaya Street, St Petersburg, 195251, Russia
    Dev Biol 313:844-62. 2008
    ..As the first quantitatively characterized morphogenetic field, this system and its behavior constitute an extraordinarily rich set of materials for the study of canalization and embryonic regulation at the molecular level...
  46. pmc Parameter estimation and determinability analysis applied to Drosophila gap gene circuits
    Maksat Ashyraliyev
    CWI, Kruislaan 413, 1098 SJ Amsterdam, The Netherlands
    BMC Syst Biol 2:83. 2008
    ..Once the parameters are found by means of optimization, it is important to assess the quality of the parameter estimates, especially if parameter values are used to draw biological conclusions from the model...
  47. ncbi Drosophila headlines
    S Cohen
    Howard Hughes Medical Institute, Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Trends Genet 7:267-72. 1991
    ..Organization of the cephalic segments uses a mechanism distinct from the familiar bierarchical cascade of segmentation genes that subdivides the trunk of the embryo...
  48. ncbi RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos
    R P Wharton
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032
    Cell 67:955-67. 1991
    ..nanos (nos) generates abdominal segmentation by blocking protein expression from maternal transcripts of the hunchback (hb) gene...
  49. ncbi Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos
    Y Murata
    Howard Hughes Medical Institute, Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710
    Cell 80:747-56. 1995
    ..embryos is governed by nanos (nos), which acts by repressing the translation of maternal transcripts of the hunchback (hb) gene...
  50. ncbi Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead
    E A Wimmer
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Mech Dev 53:235-45. 1995
    ..bcd-dependent activation also involves the activity of the morphogens of the posterior and dorsoventral systems, hunchback and dorsal, respectively, which act together to control the spatial limits of the expression domain...
  51. pmc Bicoid functions without its TATA-binding protein-associated factor interaction domains
    V Schaeffer
    Howard Hughes Medical Institute, The Rockefeller University, Box 151, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 96:4461-6. 1999
    ..Bcd needs the contribution of another anterior morphogen, Hunchback (Hb), to function properly: Bcd and Hb synergize to organize anterior development...
  52. ncbi Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline
    Lyudmila Y Kadyrova
    Howard Hughes Medical Institute, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Development 134:1519-27. 2007
    In the Drosophila embryo, Nanos and Pumilio collaborate to repress the translation of hunchback mRNA in the somatic cytoplasm...
  53. pmc Statistical lower bounds on protein copy number from fluorescence expression images
    Lee Zamparo
    Department of Computer Science and Software Engineering, Concordia University, Montreal, Quebec, Canada
    Bioinformatics 25:2670-6. 2009
    ..While this is satisfactory for many applications, for certain kinds of quantitative network modeling and analysis of expression noise, absolute measures of expression are necessary...
  54. pmc Evolutionary mirages: selection on binding site composition creates the illusion of conserved grammars in Drosophila enhancers
    Richard W Lusk
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 6:e1000829. 2010
    ..melanogaster enhancers. Thus, this study calls into question the common practice of inferring "cis-regulatory grammars" from the organization and evolutionary dynamics of developmental enhancers...
  55. doi MulteeSum: a tool for comparative spatial and temporal gene expression data
    Miriah Meyer
    Harvard University, USA
    IEEE Trans Vis Comput Graph 16:908-17. 2010
    ..We justify our design decisions based on specific descriptions of the analysis needs of our collaborators, and provide anecdotal evidence of the efficacy of MulteeSum through a series of case studies...
  56. ncbi Spatial control of the gap gene knirps in the Drosophila embryo by posterior morphogen system
    M J Pankratz
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Science 255:986-9. 1992
    ..These results provide direct molecular evidence that the posterior morphogen system interacts in a fundamentally different manner than do hunchback and bicoid, which are responsible for anterior pattern formation.
  57. ncbi Spatial regulation of the gap gene giant during Drosophila development
    R Kraut
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    Development 111:601-9. 1991
    ..immunolocalization studies show that the gt patterns overlap with protein gradients specified by the gap genes hunchback (hb) and knirps (kni)...
  58. ncbi Dual role of the Drosophila pattern gene tailless in embryonic termini
    E Steingrimsson
    Department of Biology, University of California, Los Angeles 90024
    Science 254:418-21. 1991
    ..of ectopic terminal-specific structures, the Filzkörper, and leads to the activation of at least one gene, hunchback, that is required to form these structures...
  59. ncbi A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo
    M Hulskamp
    Institut für Genetik and Mikrobiologie, Universitat Munchen, FRG
    Nature 346:577-80. 1990
    ..The gap genes are also involved in establishing the body plan, with hunchback (hb) being expressed both maternally and zygotically...
  60. pmc A novel spatial transcription pattern associated with the segmentation gene, giant, of Drosophila
    J Mohler
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    EMBO J 8:1539-48. 1989
    ..The effect of mutations in three other gap loci, Kr, kni and hb, were also analyzed.
  61. ncbi The products of the Drosophila gap genes hunchback and Krüppel bind to the hunchback promoters
    J Treisman
    Howard Hughes Medical Institute, Rockefeller University, New York 10021
    Nature 341:335-7. 1989
    ..Here we report that the Krüppel (Kr) gene product (Kr) binds to the sequence AAGGGGTTAA, whereas the hunchback (hb) gene product (Hb) recognizes the consensus ACNCAAAAAANTA...
  62. ncbi Expression, function, and regulation of the hairy segmentation protein in the Drosophila embryo
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Genes Dev 2:883-90. 1988
    ..The pattern of hairy expression in gap gene mutants that affect ftz expression indicates that the gap genes largely act indirectly upon ftz through their effects on hairy...
  63. pmc Differential regulation of target genes by different alleles of the segmentation gene hunchback in Drosophila
    M Hulskamp
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, Federal Republic of Germany
    Genetics 138:125-34. 1994
    b>hunchback (hb) is a key regulatory gene in the early segmentation gene hierarchy of Drosophila. It codes for a transcription factor of the Cys2-His2 zinc finger type and shows two separate zinc finger domains in its coding region...
  64. ncbi Synergy between the hunchback and bicoid morphogens is required for anterior patterning in Drosophila
    M Simpson-Brose
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021 6399
    Cell 78:855-65. 1994
    ..Another maternal component, hunchback (hb), can substitute for bcd in the thorax and abdomen...
  65. ncbi The eve stripe 2 enhancer employs multiple modes of transcriptional synergy
    D N Arnosti
    Department of Biology, UCSD, La Jolla 92093 0347, USA
    Development 122:205-14. 1996
    ..The bicoid (bcd) regulatory gradient triggers the expression of hunchback (hb); these work synergistically to activate the stripe in the anterior half of the embryo, bcd also coordinates ..
  66. ncbi Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity
    M D Biggin
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 208114, USA
    Development 124:4425-33. 1997
    ..In this 'widespread binding' model, cofactors act mainly by helping to distinguish the way in which homeoproteins regulate targets to which they are already bound...
  67. ncbi Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins
    D Kosman
    Brookdale Center for Molecular Biology, Box 1126, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Genes Evol 208:290-4. 1998
    ..Antigenicity of the purified recombinant proteins may be increased by precipitation in double-distilled water. The results of using the serums obtained for fluorescent staining of Drosophila embryos are shown...
  68. ncbi Segmentation: painting stripes from flies to vertebrates
    L Pick
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Dev Genet 23:1-10. 1998
  69. ncbi The Drosophila semushi mutation blocks nuclear import of bicoid during embryogenesis
    J L Epps
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    Curr Biol 8:1277-80. 1998
    ..Consequently, semi embryos have multiple defects in anterior segmentation. This study demonstrates that an E2 enzyme is required for nuclear transport during Drosophila embryogenesis...
  70. pmc Recruitment of Nanos to hunchback mRNA by Pumilio
    J Sonoda
    Howard Hughes Medical Institute HHMI, Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 13:2704-12. 1999
    Translational regulation of hunchback (hb) mRNA is essential for posterior patterning of the Drosophila embryo...
  71. ncbi Two distinct domains of Bicoid mediate its transcriptional downregulation by the Torso pathway
    F Janody
    Developmental Biology Institute of Marseille, Laboratoire de Genetique et Physiologie du Developpement, Universite de la Mediterrannee, Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 128:2281-90. 2001
    ..The alanine-rich domain contributes to this process indirectly by reducing the global activity of the protein and in particular the activity of the glutamine-rich domain that might otherwise prevent downregulation by Torso...
  72. ncbi Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes
    Sheng Zhang
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA
    Cell 108:45-56. 2002
    ..We propose that Atrophin proteins function as versatile transcriptional corepressors and discuss a model that deregulation of transcription may contribute to the pathogenesis of neurodegeneration...
  73. ncbi Grunge, related to human Atrophin-like proteins, has multiple functions in Drosophila development
    Alfrun Erkner
    Laboratoire de Genetique et Physiologie du Developpement, UMR 9943 C N R S Université, I B D M CNRS INSERM Université de la Méditerranée, Campus de Luminy Case 907, F 13288 Marseille, Cedex 09, France
    Development 129:1119-29. 2002
    ..Grunge has other regulatory functions in the leg, including the patterning of ventral parts along the entire proximodistal axis and the proper spacing of bristles in all regions...
  74. pmc Extraction of functional binding sites from unique regulatory regions: the Drosophila early developmental enhancers
    Dmitri A Papatsenko
    Department of Biology, New York University, New York, NY 10003 6688, USA
    Genome Res 12:470-81. 2002
    ..We also discuss the definition of true binding sites and the possible biological principles that govern patterning of regulatory regions and the distribution of transcriptional signals...
  75. ncbi Turnover of binding sites for transcription factors involved in early Drosophila development
    Javier Costas
    Instituto de Biologia Molecular e Celular IBMC, Universidade do Porto, Rua do Campo Alegre 823, 4150 180, Porto, Portugal
    Gene 310:215-20. 2003
    ..Finally, we detected a significant decrease in mean PWM scores for the D. virilis binding sites in the case of Hunchback. Possible explanations for this fact are discussed.
  76. ncbi Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster
    Navjot Singh
    Molecular Genetics Program, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Dev Biol 278:242-54. 2005
    ..Many of these genes, including the gap-gene hunchback, are initially activated in a broad domain across the head primordium, but later retract so that their ..
  77. ncbi Morphogens: precise outputs from a variable gradient
    Gozde Yucel
    Department of Biology, New York University, New York, NY 10003, USA
    Curr Biol 16:R29-31. 2006
    ..Several recent papers examine the patterning activities of Drosophila Bicoid, the first known molecular morphogen and reach different conclusions about the patterning power of a single morphogen gradient...
  78. ncbi Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity
    Outi Hallikas
    Molecular and Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Finland
    Cell 124:47-59. 2006
    ....
  79. pmc Dual regulation by the Hunchback gradient in the Drosophila embryo
    Dmitri Papatsenko
    Department of Molecular and Cell Biology, Division of Genetics, Genomics, and Development, and Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:2901-6. 2008
    ..Previous tissue culture assays and transgene analyses raised the possibility that Hunchback (Hb) might function as both an activator and repressor of transcription...
  80. pmc Regulation of even-skipped stripe 2 in the Drosophila embryo
    S Small
    Biology Department, UCSD, La Jolla 92093 0322
    EMBO J 11:4047-57. 1992
    ..The maternal morphogen bicoid (bcd) and the gap proteins hunchback (hb), Kruppel (Kr) and giant (gt) all bind with high affinity to closely linked sites within this small promoter ..
  81. ncbi Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant Nanos
    D D Barker
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    Genes Dev 6:2312-26. 1992
    ..We conclude that abdomen formation depends both on Nanos activity, spreading from the localized posterior source, and on Pumilio activity, present throughout the embryo...
  82. ncbi Induction of germ cell formation by oskar
    A Ephrussi
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Nature 358:387-92. 1992
    ..Of the eight genes necessary for germ cell formation at the posterior, only three, oskar, vasa and tudor, are essential at an ectopic site...
  83. ncbi Interactions of the Drosophila gap gene giant with maternal and zygotic pattern-forming genes
    E D Eldon
    Department of Cell Biology, Baylor College of Medicine, Texas Medical Center, Houston 77030
    Development 111:367-78. 1991
    ..Expression is never detected in the labial or thoracic segment primordia but persists in certain head structures, including the ring gland, until the end of embryonic development...
  84. ncbi Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo
    G Bronner
    Institut fur Genetik und Mikrobiologie, Universitat Munchen, F R G
    Mech Dev 35:205-11. 1991
    ..This, in turn, suggests that the terminal gap gene activities prevent metamerization by repression of central gap genes, thereby distinguishing the segmented trunk from the nonsegmented tail region of the embryo...
  85. pmc Gene expression mediated by cis-acting sequences of the Krüppel gene in response to the Drosophila morphogens bicoid and hunchback
    M Hoch
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, FRG
    EMBO J 10:2267-78. 1991
    ..controlled by the morphogenetic activities of the anterior organizer gene bicoid (bcd) and the anterior gap gene hunchback (hb)...
  86. ncbi Spatial control of hairy protein expression during embryogenesis
    K L Hooper
    Zoology Department, Oxford University, UK
    Development 107:489-504. 1989
    ..Our observations suggest that pair-rule striping may be under redundant control, and we discuss possible implications for hierarchical models of pair-rule gene action...
  87. pmc Gap genes define the limits of antennapedia and bithorax gene expression during early development in Drosophila
    K Harding
    Department of Biological Sciences Fairchild Center, Columbia University, New York, NY 10027
    EMBO J 7:205-14. 1988
    ..We propose that the gap genes are largely responsible for integrating the processes of segmentation and homeosis...
  88. ncbi Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis
    V E Foe
    J Cell Sci 61:31-70. 1983
    ..This highly organized cytoplasm may be involved in providing positional information for the important process of nuclear determination that is known to occur during these stages...
  89. ncbi Positional information and pattern formation in development
    L Wolpert
    Department of Anatomy and Developmental Biology, University College, London, United Kingdom
    Dev Genet 15:485-90. 1994
    ..There are striking similarities in the mechanisms for specifying and recording positional identity in Drosophila and vertebrates...
  90. ncbi Regulation of expression domains and effects of ectopic expression reveal gap gene-like properties of the linked pdm genes of Drosophila
    K A Cockerill
    Department of Biology, University of California Santa Barbara 93106
    Mech Dev 41:139-53. 1993
    ..pdm-1 expression are set by the terminal system genes torso and tailless, and the gradient morphogen encoded by hunchback. The resolution into two stripes is controlled by the gap gene knirps...
  91. ncbi A cascade of transcriptional control leading to axis determination in Drosophila
    D Niessing
    Abteilung Molekulare Entwick lungsbiologie, Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    J Cell Physiol 173:162-7. 1997
  92. pmc The Pumilio protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins
    P D Zamore
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA
    RNA 3:1421-33. 1997
    Translation of hunchback(mat) (hb[mat]) mRNA must be repressed in the posterior of the pre-blastoderm Drosophila embryo to permit formation of abdominal segments...
  93. ncbi The Pumilio RNA-binding domain is also a translational regulator
    R P Wharton
    Howard Hughes Medical Institute, Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell 1:863-72. 1998
    ..requires the action of Nanos (Nos) and Pumilio (Pum), which collaborate to regulate the translation of maternal hunchback (hb) mRNA. Previous work demonstrated that Pum recognizes sites in the 3' UTR of hb mRNA...
  94. ncbi The PUMILIO-RNA interaction: a single RNA-binding domain monomer recognizes a bipartite target sequence
    P D Zamore
    The Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02129, USA
    Biochemistry 38:596-604. 1999
    Translational repression of hunchback (hb) mRNA in the posterior of the Drosophila embryo requires two copies of a bipartite sequence, the Nanos Response Element (NRE), located in the 3' untranslated region of the mRNA...
  95. ncbi Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene
    M J Shimell
    Department of Genetics, University of Minnesota, Minneapolis, Minnesota, 55455, USA
    Dev Biol 218:38-52. 2000
    ..Previously, the Hunchback (HB) protein has been implicated in setting the anterior expression limit of the UBX homeotic protein in ..
  96. ncbi Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins
    G Struhl
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Cell 6:625-36. 2000
    ..Hence, Notch, beta-APP, and perhaps other proteins may be targeted for Presenilin-mediated transmembrane cleavage by upstream processing events that sever the extracellular domain from the rest of the protein...
  97. ncbi A logical analysis of the Drosophila gap-gene system
    L Sanchez
    Centro de Investigaciones Biologicas, Velazquez 144, Madrid, 28006, Spain
    J Theor Biol 211:115-41. 2001
    ..distinct, qualitative, functional levels associated with each of the key regulatory factors (the three maternal Bcd, Hb and Cad products, and the four gap Gt, Hb, Kr and Kni products); (2) the most crucial interactions and regulatory ..
  98. ncbi The activity of the Drosophila morphogenetic protein Bicoid is inhibited by a domain located outside its homeodomain
    Chen Zhao
    Division of Developmental Biology, Children s Hospital Research Foundation, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Development 129:1669-80. 2002
    ....
  99. ncbi FlyMove--a new way to look at development of Drosophila
    Katrin Weigmann
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Trends Genet 19:310-1. 2003
    ..Here, we introduce FlyMove (http://flymove.uni-muenster.de), a new database combining movies, animated schemata, interactive "modules" and pictures that will greatly facilitate the understanding of Drosophila development...
  100. ncbi A self-organizing system of repressor gradients establishes segmental complexity in Drosophila
    Dorothy E Clyde
    Biology Department, New York University, New York, New York 10003, USA
    Nature 426:849-53. 2003
    ..Here we show that opposing gradients of two Drosophila transcriptional repressors, Hunchback (Hb) and Knirps (Kni), position several segments by differentially repressing two distinct regulatory regions (..
  101. ncbi Dynamic control of positional information in the early Drosophila embryo
    Johannes Jaeger
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, New York 11794 3600, USA
    Nature 430:368-71. 2004
    ....

Research Grants17

  1. Compartmentalized Exosome Structure and Function
    Erik D Andrulis; Fiscal Year: 2010
    ..An in-depth understanding of how the exosome processes and degrades mRNAs is fundamentally important to human health, as aberrant gene expression is an etiological factor in numerous disease states. ..
  2. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  3. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  4. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
    ..Such knowledge may point to mechanisms that cause brain cells to revert to less differentiated states in brain tumors or degenerate in neurological disorders. ..
  5. Translational Control in Plasmodium Sexual Development
    Liwang Cui; Fiscal Year: 2005
    ....
  6. SUMO conjugation in cell biology and Development
    Albert J Courey; Fiscal Year: 2010
    ..Consequently, the research proposed here will advance our understanding of human disease. ..
  7. Development of a cell-based method for high-throughput drug screening in malaria
    Liwang Cui; Fiscal Year: 2008
    ..To facilitate antimalarial drug discovery, we propose to develop a highly sensitive, cell-based, one-step luminescent drug screen assay for high throughput screening of large chemical libraries. [unreadable] [unreadable] [unreadable]..
  8. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2001
    ..Finally, an mRNA that is deadenylated and stored in a dormant form in mouse oocytes undergoes prior CPE-mediated deadenylation. The possible role of mCPEB in the process will be assessed. ..
  9. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
    ..The cross-disciplinary nature of this meeting will be attractive to molecular, cellular, developmental, and neurobiological scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
  10. RNA and the Etiology of Disease
    Joel Richter; Fiscal Year: 2008
    ..The meeting is cross-disciplinary in its approach, which is essential for combating human disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  11. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  12. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  14. Plasmodium vivax:Proteomic Analysis of Asexual and Sporozoite Stages
    Liwang Cui; Fiscal Year: 2007
    ..Its recent resurgence in prevalence and emergence of drug- resistant parasite strains have raised a great concern for the future control of malaria. [unreadable] [unreadable] [unreadable]..
  15. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  16. Homeostatic plasticity in a rhythmic neural network
    DAVID SCHULZ; Fiscal Year: 2004
    ..This study also proposed to begin molecular analyses of homeostatic plasticity in the STG by performing the first microarray experiments on crustacean neural function. ..
  17. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..