Genomes and Genes
Gene Symbol: Gr64f
Description: Gustatory receptor 64f
Alias: CG14988, CG32255, DmGr64f, Dmel64f, Dmel\CG32255, GR64f, Gr64, Gr64A3, CG32255 gene product from transcript CG32255-RA, CG32255-PA, Gr64f-PA, gustatory receptor 64A3, gustatory receptor 64f
Species: fruit fly
- Drosophila Gr5a encodes a taste receptor tuned to trehaloseSylwester Chyb
Imperial College London, Wye Campus, Kent TN25 5AH, United Kingdom
Proc Natl Acad Sci U S A 100:14526-30. 2003..We demonstrate by heterologous expression in a Drosophila S2 cell line that Gr5a encodes a receptor tuned to trehalose. This is the first functional expression of an invertebrate taste receptor...
- A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA taggingYuchen Jiao
Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:14110-5. 2007..These data demonstrate that multiple Grs are coexpressed with Gr5a and that Drosophila Gr64a is required for the responses to multiple sugars...
- Two Gr genes underlie sugar reception in DrosophilaAnupama Dahanukar
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
Neuron 56:503-16. 2007..The simplest interpretation of our results is that Gr5a and Gr64a are each capable of functioning independently of each other within individual sugar neurons and that they are the primary receptors used in the labellum to detect sugars...
- Gr64f is required in combination with other gustatory receptors for sugar detection in DrosophilaYuchen Jiao
Department of Biological Chemistry, Department of Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Curr Biol 18:1797-801. 2008..In the current work, we demonstrate that Gr64f is required in combination with Gr5a for the behavioral response to trehalose and for production of nerve ..
- Regulation of gustatory physiology and appetitive behavior by the Drosophila circadian clockAbhishek Chatterjee
Department of Biology and Center for Biological Clocks Research, Texas A and M University, College Station, TX 77843 3258, USA
Curr Biol 20:300-9. 2010..Here we examine gustatory physiology, tastant-evoked appetitive behavior, and food ingestion to understand clock-dependent regulation of the Drosophila gustatory system...
- Optogenetic induction of aversive taste memoryAlex C Keene
Department of Biology, University of Nevada, Reno, NV, United States
Neuroscience 222:173-80. 2012..Taken together, this optogenetic system provides a powerful new tool for interrogation of the central brain circuits that mediate memory formation...
- A fructose receptor functions as a nutrient sensor in the Drosophila brainTetsuya Miyamoto
Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, TX 77845, USA
Cell 151:1113-25. 2012..Thus, our studies indicate that the Gr43a-expressing brain neurons function as a nutrient sensor for hemolymph fructose and assign opposing valence to feeding experiences in a satiation-dependent manner...
- Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5aK Ueno
Graduate School of Information Sciences, Tohoku University, Sendai 980 8579, Japan
Curr Biol 11:1451-5. 2001..Taken together, the mutation analyses support that Gr5a is allelic to Tre...
- Sugar receptors in DrosophilaJesse Slone
Duke University Medical Center, Department of Molecular Genetics and Microbiology, Durham, North Carolina 27710, USA
Curr Biol 17:1809-16. 2007..Here, we show that the Gr64 genes encode receptors for numerous sugars...
- Pharyngeal sense organs drive robust sugar consumption in DrosophilaEmily E Ledue
Department of Zoology, Cell and Developmental Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Nat Commun 6:6667. 2015....
- Identification of neurons responsible for feeding behavior in the Drosophila brainFei Sun
Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
Sci China Life Sci 57:391-402. 2014..These findings indicate that these Gal4-labeled neurons, which function downstream of sensory neurons and regulate feeding behavior towards different food sources is necessary in Drosophila feeding control. ..
- Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responsesYan Chen
Department of Molecular and Cellular Medicine, Health Science Center, Texas A and M University, College Station, TX 77843, USA
Curr Biol 24:1969-77. 2014..Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions...
- Gustatory and metabolic perception of nutrient stress in DrosophilaNancy J Linford
Department of Molecular and Integrative Physiology
Proc Natl Acad Sci U S A 112:2587-92. 2015....
- Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensingShinsuke Fujii
Department of Cellular and Molecular Medicine, Texas A and M Health Science Center, College Station, TX 77845, USA
Curr Biol 25:621-7. 2015..genome harbors a small subfamily of eight, closely related gustatory receptor (Gr) genes, Gr5a, Gr61a, and Gr64a-Gr64f, of which three have been proposed to mediate sweet taste [3-6]...
- Dual mechanism for bitter avoidance in DrosophilaAlice Sarah French
Institut National de la Recherche Agronomique, Unité Mixte de Recherche UMR Institut d Ecologie et des Sciences de l Environnement de Paris, F 78026 Versailles, France, AgroParisTech, Département Sciences de la vie et santé, F 75231 Paris, France, CNRS, Unité mixte de Recherches UMR 9191, Evolution, Génomes, Comportement, Ecologie F 91198 Gif sur Yvette, France
J Neurosci 35:3990-4004. 2015..We postulate that sugar-sensing inhibition represents a mechanism in insects to prevent ingesting harmful substances occurring within mixtures...
- Genetic and neural mechanisms that inhibit Drosophila from mating with other speciesPu Fan
State Key Laboratory of Biomembrane and Membrane Biology, School of Life Sciences, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Cell 154:89-102. 2013..Although this chemosensory pathway does not inhibit interspecies mating in D. melanogaster females, similar mechanisms appear to inhibit this behavior in many other male drosophilids...
- A genetic tool kit for cellular and behavioral analyses of insect sugar receptorsAhmet Yavuz
a Department of Cellular and Molecular Medicine Texas A and M Health Science Center College Station, TX USA
Fly (Austin) 8:189-96. 2014..Thus, the precisely engineered genetic mutations of single Gr genes and construction of a sugar-blind strain provide powerful analytical tools for examining the roles of Drosophila and other insect sugar Gr genes in sweet taste. ..
- Ionotropic Chemosensory Receptors Mediate the Taste and Smell of PolyaminesAshiq Hussain
Sensory Neurogenetics Research Group, Max Planck Institute of Neurobiology, Munich, Germany
PLoS Biol 14:e1002454. 2016..Given their universal and highly conserved biological roles, we propose that the ability to evaluate food for polyamine content may impact health and reproductive success also of other animals including humans. ..
- Peripheral coding of tasteEmily R Liman
Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA Electronic address
Neuron 81:984-1000. 2014..In this Review, we discuss recent advances in taste research, mainly from the fly and mammalian systems, and we highlight principles that are common across species, despite stark differences in receptor types. ..
- Detection of sweet tastants by a conserved group of insect gustatory receptorsErica Gene Freeman
Bioengineering Interdepartmental Graduate Program, Interdepartmental Neuroscience Program, and Department of Entomology, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521
Proc Natl Acad Sci U S A 111:1598-603. 2014..Our results provide a molecular basis for tastant detection by the entire repertoire of sweet taste receptors in the fly and lay the foundation for studying Grs in mosquitoes and other insects that transmit deadly diseases. ..
- Drosophila fatty acid taste signals through the PLC pathway in sugar-sensing neuronsPavel Masek
Department of Biology, University of Nevada, Reno, Nevada, United States of America
PLoS Genet 9:e1003710. 2013..Taken together, these findings reveal that PLC function in Drosophila sweet-sensing neurons is a conserved molecular signaling pathway that confers attraction to fatty acids. ..
- An odorant-binding protein required for suppression of sweet taste by bitter chemicalsYong Taek Jeong
Department of Oral Biology, BK21 Project, Yonsei University College of Dentistry, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
Neuron 79:725-37. 2013..These findings demonstrate an unexpected role for an OBP in taste and identify a molecular player involved in the integration of opposing attractive and aversive gustatory inputs. ..
- Identification of a Drosophila glucose receptor using Ca2+ imaging of single chemosensory neuronsTetsuya Miyamoto
Department of Molecular and Cellular Medicine, College of Medicine, Texas A and M Health Science Center, College Station, Texas, United States of America
PLoS ONE 8:e56304. 2013..Thus, single cell Ca(2+) imaging can be employed as a powerful tool to identify ligands for orphan Gr proteins...
- Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional qualityNancy J Linford
Department of Molecular and Integrative Physiology, Geriatrics Center and Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Michigan, Ann Arbor, Michigan, USA
PLoS Genet 8:e1002668. 2012..These results provide evidence that gustatory perception can alter arousal thresholds for sleep behavior in response to dietary cues and provide a mechanism by which organisms tune their behavior and physiology to environmental cues...
- Evolution of the sugar receptors in insectsLauren B Kent
Department of Entomology, University of Illinois at Urbana Champaign, 61801, USA
BMC Evol Biol 9:41. 2009..We examined the evolution of these SRs within the 12 available Drosophila genome sequences, as well as three mosquito, two moth, and beetle, bee, and wasp genome sequences...
- Taste and pheromone perception in mammals and fliesHiroaki Matsunami
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Genome Biol 4:220. 2003..Comparison of these systems in Drosophila and mouse uncovers clear differences and a few surprising similarities...
- Sensory Transduction in the Vomeronasal SystemEmily Liman; Fiscal Year: 2005....