Gr64f

Summary

Gene Symbol: Gr64f
Description: Gustatory receptor 64f
Alias: CG14988, CG32255, DmGr64f, Dmel64f, Dmel\CG32255, GR64f, Gr64, Gr64A3, CG32255 gene product from transcript CG32255-RA, CG32255-PA, Gr64f-PA, gustatory receptor 64A3, gustatory receptor 64f
Species: fruit fly

Top Publications

  1. pmc Drosophila Gr5a encodes a taste receptor tuned to trehalose
    Sylwester Chyb
    Imperial College London, Wye Campus, Kent TN25 5AH, United Kingdom
    Proc Natl Acad Sci U S A 100:14526-30. 2003
  2. pmc A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging
    Yuchen Jiao
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:14110-5. 2007
  3. pmc Two Gr genes underlie sugar reception in Drosophila
    Anupama Dahanukar
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Neuron 56:503-16. 2007
  4. pmc Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila
    Yuchen Jiao
    Department of Biological Chemistry, Department of Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 18:1797-801. 2008
  5. pmc Regulation of gustatory physiology and appetitive behavior by the Drosophila circadian clock
    Abhishek Chatterjee
    Department of Biology and Center for Biological Clocks Research, Texas A and M University, College Station, TX 77843 3258, USA
    Curr Biol 20:300-9. 2010
  6. pmc Optogenetic induction of aversive taste memory
    Alex C Keene
    Department of Biology, University of Nevada, Reno, NV, United States
    Neuroscience 222:173-80. 2012
  7. pmc A fructose receptor functions as a nutrient sensor in the Drosophila brain
    Tetsuya Miyamoto
    Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, TX 77845, USA
    Cell 151:1113-25. 2012
  8. ncbi Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a
    K Ueno
    Graduate School of Information Sciences, Tohoku University, Sendai 980 8579, Japan
    Curr Biol 11:1451-5. 2001
  9. pmc Sugar receptors in Drosophila
    Jesse Slone
    Duke University Medical Center, Department of Molecular Genetics and Microbiology, Durham, North Carolina 27710, USA
    Curr Biol 17:1809-16. 2007
  10. pmc Pharyngeal sense organs drive robust sugar consumption in Drosophila
    Emily E Ledue
    Department of Zoology, Cell and Developmental Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Commun 6:6667. 2015

Research Grants

Scientific Experts

  • Emily Liman
  • Nancy J Linford
  • Lauren B Kent
  • Hubert Amrein
  • Jesse Slone
  • Anupama Dahanukar
  • Tetsuya Miyamoto
  • Ahmet Yavuz
  • Yan Chen
  • Yuchen Jiao
  • Pavel Masek
  • Alex C Keene
  • Craig Montell
  • Seok Jun Moon
  • Ashiq Hussain
  • Shinsuke Fujii
  • Alice Sarah French
  • Emily E Ledue
  • Christopher Jagge
  • Fei Sun
  • Erica Gene Freeman
  • Xiangyu Song
  • Yong Taek Jeong
  • Pu Fan
  • Abhishek Chatterjee
  • John R Carlson
  • Ilona C Grunwald Kadow
  • Thomas Svensson
  • Elsa Quillery
  • Hiroaki Matsunami
  • Nicolas Gompel
  • Mo Zhang
  • Rickard Ignell
  • Habibe K Üçpunar
  • Sylwester Chyb
  • Yu Chieh Chen
  • Michael D Gordon
  • Ali Agha Moutaz
  • Laurent Soustelle
  • Moutaz Ali Agha
  • Aera Y Jung
  • Frédéric Marion-Poll
  • Marie Jeanne Sellier
  • Alexandra Guigue
  • Marie Ange Chabaud
  • Yves Grau
  • Pablo D Reeb
  • Aniruddha Mitra
  • Li Liu
  • Zev Wisotsky
  • Zhefeng Gong
  • Yanqiong Zhou
  • Bruno van Swinderen
  • Yijin Wang
  • Yi Chen
  • So Ra Oh
  • Sara Kwong
  • Jaewon Shim
  • Devanand S Manoli
  • Allen G Cai
  • Jeffrey Neitz
  • Chul Hoon Kim
  • Hong In Yoon
  • ADAM RENSLO
  • Bruce S Baker
  • Nirao M Shah
  • Neha Agarwal
  • Osama M Ahmed
  • K Ueno
  • Paul E Hardin
  • Shintaro Tanoue
  • Jerry H Houl
  • Qiuting Ren
  • Xiaoyue Wang
  • Ya Ting Lei
  • Jae Young Kwon
  • Joseph Daniels
  • Andrew Wickens
  • M Ohta
  • H Morita
  • S Nakajima
  • K Isono
  • Y Mikuni
  • K Yamamoto

Detail Information

Publications26

  1. pmc Drosophila Gr5a encodes a taste receptor tuned to trehalose
    Sylwester Chyb
    Imperial College London, Wye Campus, Kent TN25 5AH, United Kingdom
    Proc Natl Acad Sci U S A 100:14526-30. 2003
    ..We demonstrate by heterologous expression in a Drosophila S2 cell line that Gr5a encodes a receptor tuned to trehalose. This is the first functional expression of an invertebrate taste receptor...
  2. pmc A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging
    Yuchen Jiao
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:14110-5. 2007
    ..These data demonstrate that multiple Grs are coexpressed with Gr5a and that Drosophila Gr64a is required for the responses to multiple sugars...
  3. pmc Two Gr genes underlie sugar reception in Drosophila
    Anupama Dahanukar
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
    Neuron 56:503-16. 2007
    ..The simplest interpretation of our results is that Gr5a and Gr64a are each capable of functioning independently of each other within individual sugar neurons and that they are the primary receptors used in the labellum to detect sugars...
  4. pmc Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila
    Yuchen Jiao
    Department of Biological Chemistry, Department of Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 18:1797-801. 2008
    ..In the current work, we demonstrate that Gr64f is required in combination with Gr5a for the behavioral response to trehalose and for production of nerve ..
  5. pmc Regulation of gustatory physiology and appetitive behavior by the Drosophila circadian clock
    Abhishek Chatterjee
    Department of Biology and Center for Biological Clocks Research, Texas A and M University, College Station, TX 77843 3258, USA
    Curr Biol 20:300-9. 2010
    ..Here we examine gustatory physiology, tastant-evoked appetitive behavior, and food ingestion to understand clock-dependent regulation of the Drosophila gustatory system...
  6. pmc Optogenetic induction of aversive taste memory
    Alex C Keene
    Department of Biology, University of Nevada, Reno, NV, United States
    Neuroscience 222:173-80. 2012
    ..Taken together, this optogenetic system provides a powerful new tool for interrogation of the central brain circuits that mediate memory formation...
  7. pmc A fructose receptor functions as a nutrient sensor in the Drosophila brain
    Tetsuya Miyamoto
    Department of Molecular and Cellular Medicine, Texas A and M Health Science Center, College Station, TX 77845, USA
    Cell 151:1113-25. 2012
    ..Thus, our studies indicate that the Gr43a-expressing brain neurons function as a nutrient sensor for hemolymph fructose and assign opposing valence to feeding experiences in a satiation-dependent manner...
  8. ncbi Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a
    K Ueno
    Graduate School of Information Sciences, Tohoku University, Sendai 980 8579, Japan
    Curr Biol 11:1451-5. 2001
    ..Taken together, the mutation analyses support that Gr5a is allelic to Tre...
  9. pmc Sugar receptors in Drosophila
    Jesse Slone
    Duke University Medical Center, Department of Molecular Genetics and Microbiology, Durham, North Carolina 27710, USA
    Curr Biol 17:1809-16. 2007
    ..Here, we show that the Gr64 genes encode receptors for numerous sugars...
  10. pmc Pharyngeal sense organs drive robust sugar consumption in Drosophila
    Emily E Ledue
    Department of Zoology, Cell and Developmental Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    Nat Commun 6:6667. 2015
    ....
  11. doi Identification of neurons responsible for feeding behavior in the Drosophila brain
    Fei Sun
    Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
    Sci China Life Sci 57:391-402. 2014
    ..These findings indicate that these Gal4-labeled neurons, which function downstream of sensory neurons and regulate feeding behavior towards different food sources is necessary in Drosophila feeding control. ..
  12. pmc Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses
    Yan Chen
    Department of Molecular and Cellular Medicine, Health Science Center, Texas A and M University, College Station, TX 77843, USA
    Curr Biol 24:1969-77. 2014
    ..Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions...
  13. pmc Gustatory and metabolic perception of nutrient stress in Drosophila
    Nancy J Linford
    Department of Molecular and Integrative Physiology
    Proc Natl Acad Sci U S A 112:2587-92. 2015
    ....
  14. pmc Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing
    Shinsuke Fujii
    Department of Cellular and Molecular Medicine, Texas A and M Health Science Center, College Station, TX 77845, USA
    Curr Biol 25:621-7. 2015
    ..genome harbors a small subfamily of eight, closely related gustatory receptor (Gr) genes, Gr5a, Gr61a, and Gr64a-Gr64f, of which three have been proposed to mediate sweet taste [3-6]...
  15. doi Dual mechanism for bitter avoidance in Drosophila
    Alice Sarah French
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche UMR Institut d Ecologie et des Sciences de l Environnement de Paris, F 78026 Versailles, France, AgroParisTech, Département Sciences de la vie et santé, F 75231 Paris, France, CNRS, Unité mixte de Recherches UMR 9191, Evolution, Génomes, Comportement, Ecologie F 91198 Gif sur Yvette, France
    J Neurosci 35:3990-4004. 2015
    ..We postulate that sugar-sensing inhibition represents a mechanism in insects to prevent ingesting harmful substances occurring within mixtures...
  16. pmc Genetic and neural mechanisms that inhibit Drosophila from mating with other species
    Pu Fan
    State Key Laboratory of Biomembrane and Membrane Biology, School of Life Sciences, Peking Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
    Cell 154:89-102. 2013
    ..Although this chemosensory pathway does not inhibit interspecies mating in D. melanogaster females, similar mechanisms appear to inhibit this behavior in many other male drosophilids...
  17. pmc A genetic tool kit for cellular and behavioral analyses of insect sugar receptors
    Ahmet Yavuz
    a Department of Cellular and Molecular Medicine Texas A and M Health Science Center College Station, TX USA
    Fly (Austin) 8:189-96. 2014
    ..Thus, the precisely engineered genetic mutations of single Gr genes and construction of a sugar-blind strain provide powerful analytical tools for examining the roles of Drosophila and other insect sugar Gr genes in sweet taste. ..
  18. pmc Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines
    Ashiq Hussain
    Sensory Neurogenetics Research Group, Max Planck Institute of Neurobiology, Munich, Germany
    PLoS Biol 14:e1002454. 2016
    ..Given their universal and highly conserved biological roles, we propose that the ability to evaluate food for polyamine content may impact health and reproductive success also of other animals including humans. ..
  19. pmc Peripheral coding of taste
    Emily R Liman
    Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA Electronic address
    Neuron 81:984-1000. 2014
    ..In this Review, we discuss recent advances in taste research, mainly from the fly and mammalian systems, and we highlight principles that are common across species, despite stark differences in receptor types. ..
  20. pmc Detection of sweet tastants by a conserved group of insect gustatory receptors
    Erica Gene Freeman
    Bioengineering Interdepartmental Graduate Program, Interdepartmental Neuroscience Program, and Department of Entomology, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521
    Proc Natl Acad Sci U S A 111:1598-603. 2014
    ..Our results provide a molecular basis for tastant detection by the entire repertoire of sweet taste receptors in the fly and lay the foundation for studying Grs in mosquitoes and other insects that transmit deadly diseases. ..
  21. pmc Drosophila fatty acid taste signals through the PLC pathway in sugar-sensing neurons
    Pavel Masek
    Department of Biology, University of Nevada, Reno, Nevada, United States of America
    PLoS Genet 9:e1003710. 2013
    ..Taken together, these findings reveal that PLC function in Drosophila sweet-sensing neurons is a conserved molecular signaling pathway that confers attraction to fatty acids. ..
  22. pmc An odorant-binding protein required for suppression of sweet taste by bitter chemicals
    Yong Taek Jeong
    Department of Oral Biology, BK21 Project, Yonsei University College of Dentistry, 250 Seongsanno, Seodaemun gu, Seoul 120 752, Korea
    Neuron 79:725-37. 2013
    ..These findings demonstrate an unexpected role for an OBP in taste and identify a molecular player involved in the integration of opposing attractive and aversive gustatory inputs. ..
  23. pmc Identification of a Drosophila glucose receptor using Ca2+ imaging of single chemosensory neurons
    Tetsuya Miyamoto
    Department of Molecular and Cellular Medicine, College of Medicine, Texas A and M Health Science Center, College Station, Texas, United States of America
    PLoS ONE 8:e56304. 2013
    ..Thus, single cell Ca(2+) imaging can be employed as a powerful tool to identify ligands for orphan Gr proteins...
  24. pmc Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality
    Nancy J Linford
    Department of Molecular and Integrative Physiology, Geriatrics Center and Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Genet 8:e1002668. 2012
    ..These results provide evidence that gustatory perception can alter arousal thresholds for sleep behavior in response to dietary cues and provide a mechanism by which organisms tune their behavior and physiology to environmental cues...
  25. pmc Evolution of the sugar receptors in insects
    Lauren B Kent
    Department of Entomology, University of Illinois at Urbana Champaign, 61801, USA
    BMC Evol Biol 9:41. 2009
    ..We examined the evolution of these SRs within the 12 available Drosophila genome sequences, as well as three mosquito, two moth, and beetle, bee, and wasp genome sequences...
  26. pmc Taste and pheromone perception in mammals and flies
    Hiroaki Matsunami
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Genome Biol 4:220. 2003
    ..Comparison of these systems in Drosophila and mouse uncovers clear differences and a few surprising similarities...

Research Grants1

  1. Sensory Transduction in the Vomeronasal System
    Emily Liman; Fiscal Year: 2005
    ....