futsch

Summary

Gene Symbol: futsch
Description: CG34387 gene product from transcript CG34387-RF
Alias: 22C10, 22C10/FUTSCH, 22C20, 22c10, CG14772, CG3064, CG34387, Dmel\CG34387, Dmel_CG14772, Dmel_CG3064, EG:49E4.1, FUTSCH, Futch, Futsch, MAP-IB, MAP1B, MAb22C10, Mab 22C10, Mab22C10, Mab22c10, Map-1B, Map1B, Olk, lincRNA.936, mAb 22C10, mAb-22C10, mAb22C10, mAb22c10, map1b, olk, ssC10, CG34387 gene product from transcript CG34387-RF, CG34387-PC, CG34387-PE, CG34387-PF, futch, futsch-PC, futsch-PE, futsch-PF, omb-like
Species: fruit fly

Top Publications

  1. ncbi Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function
    Y Q Zhang
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Cell 107:591-603. 2001
  2. ncbi The glial cell undergoes apoptosis in the microchaete lineage of Drosophila
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Development 130:123-33. 2003
  3. ncbi Pruning of motor neuron branches establishes the DLM innervation pattern in Drosophila
    Sarita Hebbar
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    J Neurobiol 60:499-516. 2004
  4. pmc A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene
    G Gregory Neely
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Cell 143:628-38. 2010
  5. pmc The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation
    Mary Packard
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Cell 111:319-30. 2002
  6. ncbi Dynactin is necessary for synapse stabilization
    Benjamin A Eaton
    Department of Biochemistry and Biophysics, San Francisco, California 94143, USA
    Neuron 34:729-41. 2002
  7. ncbi The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation
    Petra I zur Lage
    The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Development 130:4683-93. 2003
  8. ncbi Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development
    T Hummel
    Institut fur Neurobiologie, Universitat Munster, Germany
    Neuron 26:357-70. 2000
  9. ncbi Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila
    Zhefeng Gong
    Biology Department, University of Virginia, Charlottesville, Virginia 22904, USA
    J Neurosci 24:9059-66. 2004
  10. ncbi Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation
    Raphaelle Dubruille
    Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 5534, Universite Claude Bernard Lyon 1, 69622 Villeurbanne, France
    Development 129:5487-98. 2002

Scientific Experts

Detail Information

Publications142 found, 100 shown here

  1. ncbi Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function
    Y Q Zhang
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Cell 107:591-603. 2001
    ..These phenotypes mimic those observed in mutants of microtubule-associated Futsch. Immunoprecipitation of dFXR shows association with futsch mRNA, and Western analyses demonstrate that dFXR ..
  2. ncbi The glial cell undergoes apoptosis in the microchaete lineage of Drosophila
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Development 130:123-33. 2003
    ..Finally, we present evidences showing that glial cells are committed to apoptosis independently of gcm and prospero expression. We suggest that apoptosis is triggered by a cell autonomous mechanism...
  3. ncbi Pruning of motor neuron branches establishes the DLM innervation pattern in Drosophila
    Sarita Hebbar
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    J Neurobiol 60:499-516. 2004
    ..Our results demonstrate that electrical activity regulates the patterning of DLM innervation during metamorphosis...
  4. pmc A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene
    G Gregory Neely
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Cell 143:628-38. 2010
    ..Intriguingly, in α2δ3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing...
  5. pmc The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation
    Mary Packard
    Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
    Cell 111:319-30. 2002
    ..We suggest that Wg signals the coordinated development of pre- and postsynaptic compartments...
  6. ncbi Dynactin is necessary for synapse stabilization
    Benjamin A Eaton
    Department of Biochemistry and Biophysics, San Francisco, California 94143, USA
    Neuron 34:729-41. 2002
    ..Our data suggests that dynactin functions locally within the presynaptic arbor to promote synapse stability...
  7. ncbi The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation
    Petra I zur Lage
    The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Development 130:4683-93. 2003
    ..This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes...
  8. ncbi Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development
    T Hummel
    Institut fur Neurobiologie, Universitat Munster, Germany
    Neuron 26:357-70. 2000
    Here we report the description of the Drosophila gene futsch, which encodes a protein recognized by the monoclonal antibody 22C10 that has been widely used to visualize neuronal morphology and axonal projections...
  9. ncbi Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila
    Zhefeng Gong
    Biology Department, University of Virginia, Charlottesville, Virginia 22904, USA
    J Neurosci 24:9059-66. 2004
    ..A functional green fluorescence protein-IAV fusion protein shows that the channel is restricted to the proximal cilium, constraining models for channel activation...
  10. ncbi Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation
    Raphaelle Dubruille
    Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 5534, Universite Claude Bernard Lyon 1, 69622 Villeurbanne, France
    Development 129:5487-98. 2002
    ..These results identify Rfx as an essential regulator of ciliated sensory neuron differentiation in Drosophila...
  11. pmc Formin-dependent synaptic growth: evidence that Dlar signals via Diaphanous to modulate synaptic actin and dynamic pioneer microtubules
    Catherine Pawson
    Department of Biochemistry and Biophysics, Programs in Neuroscience and Cell Biology, University of California, San Francisco, San Francisco, California 94158 2822, USA
    J Neurosci 28:11111-23. 2008
    ..within the NMJ that are distinct from the bundled core of microtubules identified by the MAP1b-like protein Futsch. Defects in both synaptic actin and dynamic pioneer microtubules are correlated with impaired synaptic growth in ..
  12. ncbi CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein
    Annette Schenck
    Department of Molecular Pathology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Boite Postale 10142, 67404 Illkirch, Cedex, France
    Neuron 38:887-98. 2003
    ..CYFIP interacts biochemically and genetically with dFMR1 and dRac1. Finally, CYFIP acts as a dRac1 effector that antagonizes FMR1 function, providing a bridge between signal-dependent cytoskeleton remodeling and translation...
  13. ncbi cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs
    S E Goulding
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, United Kingdom
    Dev Biol 221:120-31. 2000
    ..Moreover, in prospero mutants, in which axon and dendrite outgrowth is defective, cato is strongly derepressed in the developing CNS...
  14. pmc An IFT-A protein is required to delimit functionally distinct zones in mechanosensory cilia
    Eugene Lee
    Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794, USA
    Curr Biol 18:1899-906. 2008
    ..We describe novel structural and functional roles for IFT-A proteins in chordotonal organs, insect mechanosensory organs with cilia that are both sensory and motile...
  15. pmc The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathway
    K Sawamoto
    Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    J Cell Biol 146:361-72. 1999
    ..These results indicate that DRal regulates developmental cell shape changes through the JNK pathway...
  16. ncbi amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge
    S E Goulding
    Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
    Neuron 25:69-78. 2000
    ..We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS...
  17. ncbi spalt-dependent switching between two cell fates that are induced by the Drosophila EGF receptor
    P R Elstob
    Medical Research Council, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
    Development 128:723-32. 2001
    ..Together, these studies help to explain how one generic signaling pathway can trigger the differentiation of two distinct cell types...
  18. pmc Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complex
    C M Murawsky
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO Rep 2:1089-94. 2001
    ..We also demonstrate that dMi-2 and Ttk interact genetically, indicating a functional interaction in vivo. We propose that Ttk69 represses some target genes by remodelling chromatin structure through the recruitment of the dNuRD complex...
  19. pmc Roundabout 2 regulates migration of sensory neurons by signaling in trans
    Rachel Kraut
    Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 14:1319-29. 2004
    ..The development of Drosophila embryonic sense organs provides a neuronal migration paradigm where the in vivo roles of Slit and Robo can be assayed using genetics...
  20. pmc Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function
    Nina Tang Sherwood
    Broad Center, Division of Biology, California Institute of Technology Pasadena, California, USA
    PLoS Biol 2:e429. 2004
    ....
  21. ncbi Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint
    James Ashley
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 25:5943-55. 2005
    ..These results provide a novel mechanism by which cell adhesion molecules are regulated and provide fresh insights into the normal operation of APP during synapse development...
  22. ncbi Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal development
    Evgueni A Sevrioukov
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697, USA
    Genesis 45:184-93. 2007
    ..Our results demonstrate that developmental PCD regulation in the fly does not rely upon the Bcl-2 proteins, but that they provide an added layer of protection in the apoptotic response to stress...
  23. doi Organization and function of the blood-brain barrier in Drosophila
    Tobias Stork
    Institut fur Neurobiologie, Universitat Munster, D 48149 Münster Germany
    J Neurosci 28:587-97. 2008
    ....
  24. ncbi split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo
    B Kuang
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville TN 37232 0295, USA
    Development 127:1517-29. 2000
    ..We propose that Spen proteins regulate the expression of key effectors of signaling pathways required to specify neuronal cell fate and morphology...
  25. ncbi The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system
    M L Huang
    Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
    Neuron 25:57-67. 2000
    ..Amos interacts with the ubiquitously expressed Daughter-less protein in vivo and in vitro. Our final misexpression experiments suggest that a domain located outside the DNA-binding domain of Amos determines the MD neuronal specificity...
  26. ncbi Highwire, rpm-1, and futsch: balancing synaptic growth and stability
    Q Chang
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 26:287-90. 2000
  27. pmc Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins
    M Aguilera
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002J, Spain
    Genetics 155:1231-44. 2000
    ..In addition to ARI homologues, the RBR signature is also found in the Parkinson-disease-related protein Parkin adjacent to an ubiquitin-like domain, suggesting that the study of this mechanism could be relevant for human pathology...
  28. ncbi Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics
    T P Newsome
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 127:851-60. 2000
    ..Rather, we suggest that PTP69D plays a permissive role, perhaps reducing the adhesion of R1-R6 and R7 growth cones to the pioneer R8 axon so that they can respond independently to their specific targeting cues...
  29. ncbi Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling
    N M White
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 127:1681-9. 2000
    ..Our results strongly suggest that Atonal regulates signalling and other properties of R8 precursors...
  30. pmc The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization
    T Hummel
    Institut fur Neurobiologie, Universitat Munster, D 48149 Munster, Germany
    Genes Dev 14:863-73. 2000
    ..In addition, the kette mutant phenotype can be partially rescued by expression of an activated DRAC1 transgene. Our data suggest an important role of the HEM-2 protein in cytoskeletal organization during axonal pathfinding...
  31. ncbi Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth
    J Roos
    Dept Biochemistry and Biophysics, University of California, San Francisco 94143, USA
    Neuron 26:371-82. 2000
    We present evidence that Futsch, a novel protein with MAP1B homology, controls synaptic growth at the Drosophila neuromuscularjunction through the regulation of the synaptic microtubule cytoskeleton...
  32. ncbi split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells
    F Chen
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Curr Biol 10:943-6. 2000
    ..Therefore, spen encodes a positively acting component of the DER/Ras signaling pathway...
  33. ncbi Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
    R Nolo
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 102:349-62. 2000
    ..Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs...
  34. pmc Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling
    S Ben-Yaacov
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 152:1-13. 2001
    ..The nature of the Wsp mutant phenotypes, coupled with genetic interaction studies, identifies an essential role for Wsp in lineage decisions mediated by the Notch signaling pathway...
  35. ncbi Drosophila regulatory factor X is an embryonic type I sensory neuron marker also expressed in spermatids and in the brain of Drosophila
    C Vandaele
    Centre de Génétique Moléculaire et Cellulaire U M R 5534, Laboratoire des Mécanismes Moléculaires et Cellulaires du Développement, Universite Claude Bernard Lyon I, 43, Boulevard du 11 Novembre 1918, F 69622 Villeurbanne, France
    Mech Dev 103:159-62. 2001
    ..In addition, dRFX is also detected in the brain throughout development and in spermatids in adult flies...
  36. ncbi Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression
    Claas A Meyer
    Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
    Development 129:319-28. 2002
    ..The dacapo regulatory region includes many independent cis-regulatory elements. The elements that control epidermal expression integrate developmental cues that time the arrest of cell proliferation...
  37. ncbi The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function
    Guillermo Marques
    The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Neuron 33:529-43. 2002
    ..These results reveal a novel role for BMP signaling in regulating Drosophila neuromuscular junction synapse assembly and activity and may indicate that similar pathways could govern vertebrate synapse development...
  38. ncbi Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis
    Karin Dumstrei
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, 90095, USA
    Development 129:3983-94. 2002
    ..Finally, EGFR can be co-immunoprecipitated with anti-DE-cadherin and anti-Armadillo antibodies from embryonic protein extracts. We propose that EGFR signaling plays a role in morphogenesis by modulating cell adhesion...
  39. ncbi Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons
    Wesley B Grueber
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Room U226, San Francisco, CA 94143, USA
    Cell 112:805-18. 2003
    ..Thus, different levels of a homeoprotein can regulate distinct patterns of dendrite branching...
  40. ncbi Novel isoforms of Dlg are fundamental for neuronal development in Drosophila
    Carolina Mendoza
    Programa de Fisiologia y Biofisica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile 6530499
    J Neurosci 23:2093-101. 2003
    ..During embryonic development, proteins that include the S97N domain are essential for proper neuronal differentiation and organization, acting through mechanisms that may include the adequate localization of cell fate determinants...
  41. pmc Even-skipped, acting as a repressor, regulates axonal projections in Drosophila
    Miki Fujioka
    Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Development 130:5385-400. 2003
    ..Finally, homologues of Eve from diverse species were able to rescue the eve mutant phenotype, indicating conservation of both targeting and repression functions in the nervous system...
  42. ncbi Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm
    Young Goo Han
    Graduate Program in Genetics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Curr Biol 13:1679-86. 2003
    ..The nompB gene is here shown to encode an IFT protein. Its mutant phenotypes reveal the consequences of an IFT defect in an insect...
  43. ncbi Initial state of the Drosophila eye before dorsoventral specification is equivalent to ventral
    Amit Singh
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 130:6351-60. 2003
    ..Therefore, we propose that early state of the eye prior to DV lineage restriction is equivalent to ventral and requires L and Ser gene function...
  44. ncbi A conserved developmental program for sensory organ formation in Drosophila melanogaster
    Nao Niwa
    Division of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Nat Genet 36:293-7. 2004
    ..Our findings strongly suggest that various sensory organs evolved from an ato-dependent protosensory organ through segment specification by ey and Hox genes...
  45. ncbi A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity
    Eric C Lai
    Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Dev Biol 269:1-17. 2004
    ..We propose that most Drosophila sensory organs are built from an archetypal lineage, and we speculate about how this stereotyped pattern of cell divisions may have been built during evolution...
  46. pmc New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants
    Catalina Ruiz-Canada
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Neuron 42:567-80. 2004
    ..At the presynapse, aPKC regulates the stability of MTs by promoting the association of the MAP1Brelated protein Futsch to MTs...
  47. pmc Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons
    Rachel L Griffiths
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, Cambridge, UK
    EMBO J 23:2440-50. 2004
    ..This enables prospero-expressing cells alone to divide further upon elimination of neurons and to adjust glial number to axons during development...
  48. ncbi Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis
    Tong Wey Koh
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 43:193-205. 2004
    ..Our data suggest that Dap160, like dynamin, is involved in synaptic vesicle retrieval at active and periactive zones...
  49. ncbi Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth
    Bruno Marie
    Department of Biochemistry and Biophysics, 1550 4th Street, GDBS Fourth Floor North, University of California, San Francisco, 94143, USA
    Neuron 43:207-19. 2004
    ..We present a model in which Dap160 scaffolds both endocytic machinery and essential synaptic signaling systems to the periactive zone to coordinately control structural and functional synapse development...
  50. ncbi Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila
    Bénédicte Franco
    Laboratoire de Génomique Fonctionnelle, Unité Propre de Recherche Centre National de la Recherche Scientifique 2580, 34094 Montpellier Cedex 5, France
    J Neurosci 24:6573-7. 2004
    ..Finally, we show that Sgg controlled the microtubule cytoskeleton dynamics in the motoneuron and that Futsch, a microtubule-associated protein, was required for Shaggy function on synaptic growth.
  51. pmc The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites
    Lynn M Powell
    Division of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, United Kingdom
    Mol Cell Biol 24:9517-26. 2004
    ..While the latter finding shows that enhancer context is also important in defining how proneural proteins interact with these sites, it is clear that differential utilization of DNA binding sites underlies proneural protein specificity...
  52. ncbi EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulation
    Petra I zur Lage
    Division of Biomedical Sciences, Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    Dev Cell 7:687-96. 2004
    ..This exemplifies a simple and general mechanism for regulating the transition from competence to cell fate commitment whereby a cell signal directly targets the autoregulation of a selector gene...
  53. ncbi Genetic analysis of an overlapping functional requirement for L1- and NCAM-type proteins during sensory axon guidance in Drosophila
    Lars V Kristiansen
    Instituto de Neurociencias CSIC UMH, Universidad Miguel Hernandez, Sant Joan d Alacant, 03550 Spain
    Mol Cell Neurosci 28:141-52. 2005
    ..Moreover, our findings demonstrate that this functionally redundant specificity to mediate axon guidance has been conserved in their vertebrate homologs, L1-CAM and NCAM...
  54. pmc Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila
    Alexandre Bettencourt Da Cruz
    CROET Oregon Health and Science University, Portland, OR 97239, USA
    Mol Biol Cell 16:2433-42. 2005
    ..Here we show that Futsch, the fly homolog of MAP1B, is involved in progressive neurodegeneration...
  55. ncbi Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles
    Kyle E Miller
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 15:684-9. 2005
    ..It suggests the synaptic strength and morphology defects linked to Liprin-alpha may in part be due to a failure in the delivery of synaptic-vesicle precursors...
  56. ncbi Presynaptic spectrin is essential for synapse stabilization
    Jan Pielage
    Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Curr Biol 15:918-28. 2005
    ..Precise neural circuitry is established and maintained through a regulated balance of synapse stabilization and disassembly. Currently, little is known about the molecular mechanisms that specify synapse stability versus disassembly...
  57. ncbi Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila
    Jose Bessa
    Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide Consejo Superior de Investigaciones Científicas, Seville, 41013, Spain
    Development 132:5011-20. 2005
    ..Under these conditions, though, terminal eye differentiation proceeds only if tsh expression is transient...
  58. pmc Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP
    Bulent Ataman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Proc Natl Acad Sci U S A 103:7841-6. 2006
    ..These results provide a mechanism by which DFz2 is transported from the postsynaptic membrane to the postsynaptic nucleus during synapse formation and implicate dGRIP as an essential molecule in the transport of this signal...
  59. ncbi The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction
    Natasha M Viquez
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:9293-303. 2006
    ..Hence, wrd promotes the function of PP2A and is required for normal cytoskeletal organization, synaptic growth, and synaptic function at the Drosophila NMJ...
  60. pmc Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos
    Eimear E Holohan
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    BMC Dev Biol 6:53. 2006
    ..The control of these phases and the transition between them appear to be central to the mechanism of neurogenesis. We present the first investigation of the regulation of the proneural gene, amos...
  61. ncbi Causative role of oxidative stress in a Drosophila model of Friedreich ataxia
    Jose V Llorens
    Departament de Genetica, Universitat de Valencia, Carrer Doctor Moliner 50, 46100 Burjassot, Valencia, Spain
    FASEB J 21:333-44. 2007
    ..We propose that in FA, the oxidative mediated inactivation of aconitase, which occurs normally during the aging process, is enhanced due to the lack of frataxin...
  62. pmc Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules
    Xinnan Wang
    Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
    Nat Neurosci 10:177-85. 2007
    ....
  63. ncbi Circadian changes in Drosophila motor terminals
    Kerstin I Mehnert
    Zoology Department, Stockholm University, Stockholm, Sweden
    Dev Neurobiol 67:415-21. 2007
    ..These unexpected results reveal further circadian as well as nonclock related pleiotropic effects for these classic behavioral mutants...
  64. ncbi A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport
    Eunju Pack-Chung
    Program in Neurobiology, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 10:980-9. 2007
    ..Our data thus indicate that Imac transports components required for synaptic maturation and provide insight into presynaptic maturation as a process that can be differentiated from axon outgrowth and targeting...
  65. pmc A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development
    Amir Orian
    Division of Basic Sciences, Genomic Resource, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 104:15771-6. 2007
    ..Our results suggest that the dMyc-Groucho complex defines a previously undescribed mechanism of Myc function and may serve as the transcriptional unit that integrates EGF and Notch inputs to regulate early neuronal development...
  66. ncbi Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape
    Shiho Jinushi-Nakao
    RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Neuron 56:963-78. 2007
    ..Hence, this study gives significant general insight into how multiple transcription factors combine to control class-specific dendritic arbor morphology through controlling different aspects of the cytoskeleton...
  67. doi MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site
    Beiyan Zou
    Department of Biology, Center for Molecular and Cellular Neuroscience, and Intercollege Graduate Program in Genetics, 201 Life Sciences Building, Pennsylvania State University, University Park, PA 16802, USA
    Biochem J 414:63-71. 2008
    ..MAP1 function in Drosophila appears to be fulfilled by a single gene, futsch. Although the futsch gene product is known to share several important functional properties with mammalian MAP1s, ..
  68. pmc A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158 2822, USA
    Neuron 58:195-209. 2008
    ..We propose that a presynaptic Ank2-L lattice links synaptic membrane proteins and spectrin to the underlying microtubule cytoskeleton to organize and stabilize the presynaptic terminal...
  69. doi Drosophila ankyrin 2 is required for synaptic stability
    Iris Koch
    Max Planck Institute for Developmental Biology, Department III Genetics, Spemannstrasse 35, 72076 Tubingen, Germany
    Neuron 58:210-22. 2008
    ..Interestingly, Ank2 functions downstream of spectrin in the anchorage of synaptic microtubules, providing the cytoskeletal scaffold that is essential for synaptic stability...
  70. pmc A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism
    Anuradha Ratnaparkhi
    Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 3:e2334. 2008
    ..This new fly model of ALS, with its robust pathological phenotypes, should for the first time allow the power of unbiased screens in Drosophila to be applied to study of motor neuron diseases...
  71. pmc Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction
    Claudia Miech
    F M Kirby Neurobiology Center, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 28:10875-84. 2008
    ....
  72. pmc Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons
    Mari Palgi
    Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 106:2429-34. 2009
    ..The rescue experiments confirm DmMANF as a functional ortholog of the human MANF gene thus opening the window for comparative studies of this protein family with potential for the treatment of Parkinson's disease...
  73. doi Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation
    Shan Jin
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Development 136:1571-81. 2009
    ..As defective microtubules are implicated in many neurological and developmental diseases, our work on TBCE may offer novel insights into their basis...
  74. doi Genomic mapping and expression patterns of C380, OK6 and D42 enhancer trap lines in the larval nervous system of Drosophila
    Subhabrata Sanyal
    Department of Cell Biology, Emory University of Medicine, Room No 444, 615 ichael Street, NE, Atlanta, GA 30322, USA
    Gene Expr Patterns 9:371-80. 2009
    ..three P-element transposon insertion, C380, (BG380), OK6, and D42, shows that these insertions lie upstream of the futsch, Rapgap 1 and toll-6 gene, respectively ...
  75. pmc PP2A and GSK-3beta act antagonistically to regulate active zone development
    Natasha M Viquez
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:11484-94. 2009
    ..These data suggest that PP2A and GSK-3beta function antagonistically to control active zone development, providing a potential mechanism for regulating synaptic efficacy at a single release site...
  76. doi On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages
    Gerald Udolph
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
    Dev Biol 336:156-68. 2009
    ..Thus, there is differential requirement for insc for cell fate specification depending on the stage of lineage progression of NBs...
  77. pmc Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton
    Catherine M Massaro
    Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 187:101-17. 2009
    ....
  78. pmc The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis
    Petra I zur Lage
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 10:34. 2010
    ..cousin of atonal (cato) encodes one such factor that is expressed widely in the developing sensory nervous system of Drosophila. However, nothing definitive was known of its function owing to the lack of specific mutations...
  79. pmc DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization
    Joost Schulte
    Department of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, The Picower Institute for Learning and Memory, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:5189-203. 2010
    ..These findings suggest a novel role for Phocein proteins in the regulation of axonal transport, neurite elongation, synapse formation, and microtubule organization...
  80. pmc The role of the TRP channel NompC in Drosophila larval and adult locomotion
    Li E Cheng
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 67:373-80. 2010
    ..Taken together, our findings suggest that NompC mediates proprioception in locomotion and support its role as a mechanosensitive channel...
  81. pmc Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury
    Xin Xiong
    Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 191:211-23. 2010
    ..Our data suggest that the regulation of Wnd protein turnover by Hiw can function as a damage surveillance mechanism for responding to axonal injury...
  82. pmc LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction
    Seongsoo Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 30:16959-69. 2010
    ..At the presynapse, LRRK2 phosphorylates and negatively regulates the microtubule (MT)-binding protein Futsch. These results implicate synaptic dysfunction caused by deregulated protein synthesis and aberrant MT dynamics in ..
  83. pmc The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons
    Sebastian Cachero
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 9:e1000568. 2011
    ..In addition, it provides a paradigm for how transcriptional regulation may modulate the ciliogenesis pathway to give rise to structurally and functionally specialised ciliary dendrites...
  84. pmc Stathmin is required for stability of the Drosophila neuromuscular junction
    Ethan R Graf
    Department of Biology and Neuroscience Program, Amherst College, Amherst, Massachusetts 01002, USA
    J Neurosci 31:15026-34. 2011
    ....
  85. pmc Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration
    Jill S Wentzell
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neurobiol Dis 46:78-87. 2012
    ..Because we show protective effects in mutants that affect different genes (AMP-activated protein kinase, MAP1b, rasGAP), we propose that the protective effect is not due to a genetic interaction between APPL and these genes ..
  86. pmc Transsynaptic coordination of synaptic growth, function, and stability by the L1-type CAM Neuroglian
    Eva Maria Enneking
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    PLoS Biol 11:e1001537. 2013
    ....
  87. ncbi Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes
    E C Lai
    Department of Biology, Center for Molecular Genetics, University of California San Diego, La Jolla, CA, USA
    Development 127:291-306. 2000
    ..These results suggest that Bearded family genes encode a novel class of effectors or modulators of Notch signaling...
  88. pmc Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila
    Eugenia Villa-Cuesta
    Centro de Biologia Molecular Severo Ochoa, CSIC and Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Genetics 163:1403-12. 2003
    ..This ability might be related to the wild-type function of amos in promoting development of large clusters of closely spaced olfactory sensilla...
  89. ncbi Embryonic expression pattern of the Drosophila Kallmann syndrome gene kal-1
    Davide Andrenacci
    Institute of Genetics and Biophysics, A Buzzati Traverso, CNR Via P Castellino 111, 80131 Napoli, Italy
    Gene Expr Patterns 5:67-73. 2004
    ..This is the first time that the expression of a kal-1 ortholog has been demonstrated to be sex specific making the kal-1 transcript a useful tool for the study of sex determination in the gonad...
  90. pmc Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1
    Akifumi Mizutani
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    EMBO J 24:3339-51. 2005
    ..Our study thus establishes that Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in SCA1 animals...
  91. ncbi The dorsal-open group gene raw is required for restricted DJNK signaling during closure
    C L Byars
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA anthea
    Development 126:4913-23. 1999
    ..Taken together, our results demonstrate a role for Raw in restriction of epidermal signaling during closure and suggest that this effect may be mediated via the amnioserosa...
  92. pmc Genes regulating dendritic outgrowth, branching, and routing in Drosophila
    F B Gao
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California at San Francisco, San Francisco, California 94143 0725, USA
    Genes Dev 13:2549-61. 1999
    ..These findings begin to reveal the molecular mechanisms controlling dendritic morphogenesis...
  93. ncbi The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila
    B Lilly
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, P O Box 85800, San Diego, CA 92186, USA
    Mech Dev 88:195-205. 1999
    ..Our analysis shows that dlim1 has been evolutionarily conserved, however the Drosophila lim1 gene exhibits unique properties that distinguishes it from its vertebrate homologs...
  94. ncbi Glia dictate pioneer axon trajectories in the Drosophila embryonic CNS
    A Hidalgo
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, UK
    Development 127:393-402. 2000
    ..Secondly, glia direct the fasciculation and defasciculation of axons, which pattern the pioneer pathways. Together these events are essential for the selective fasciculation of follower axons along the longitudinal pathways...
  95. ncbi Drosophila grain encodes a GATA transcription factor required for cell rearrangement during morphogenesis
    S Brown
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Development 127:4867-76. 2000
    ..This is the first gene that has been shown to affect epithelial morphogenesis by controlling cell rearrangements, and suggests a novel function for GATA transcription factors...
  96. ncbi Pathfinding by sensory axons in Drosophila: substrates and choice points in early lch5 axon outgrowth
    K L Harris
    School of Biological Sciences, University of New England, Armidale, NSW, Australia
    J Neurobiol 48:243-55. 2001
    ..At the second choice point (TP2), the lch5 growth cones make their first contact with other axons and turn ventrally toward the CNS, fasciculating specifically with the motor axons of the ISN...
  97. ncbi Context-dependent utilization of Notch activity in Drosophila glial determination
    Yoshihiko Umesono
    Division of Developmental Genetics, National Institute of Genetics, Department of Genetics, Graduate University for Advanced Studies, Mishima, 411 8540, Japan
    Development 129:2391-9. 2002
    ..We present evidence that POU-domain protein Nubbin/PDM-1 is one of the factors that provide such context...
  98. ncbi Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogaster
    Rafael Cantera
    Zoology Department, Stockholm University, S 106 91 Stockholm, Sweden
    Development 129:5577-86. 2002
    ..Effects on the expression of these genes are persistent but many morphological aspects of the phenotype are transient, leading to the concept of sequential redundancy for stable organisation of the central nervous system...
  99. pmc The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila
    Ho Juhn Song
    Department of Zoology, Oregon State University, Corvallis, Oregon 97331 2914, USA
    Genetics 162:1703-24. 2002
    ..Our results suggest that one of fru's sex-nonspecific roles is to regulate the pathfinding ability of axons in the embryonic CNS...
  100. ncbi Transcriptional regulation of glial cell specification
    Gianluca Ragone
    Institut de Génétique et Biologie Moléculaire et Cellulaire, IGBMC CNRS ULP INSERM BP 10142 67404 ILLKIRCH, C U, de Strasbourg, France
    Dev Biol 255:138-50. 2003
    ..Both negative and positive regulation are required to control glide/gcm expression, indicating that gliogenesis is actively repressed in some neural lineages...
  101. ncbi The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS
    Tetyana Shandala
    Centre for the Molecular Genetics of Development, Adelaide University, Adelaide SA 5005, Australia
    Development 130:1505-13. 2003
    ..This suggests that loco and pros are targets of DRI transcriptional activation in some LG. We conclude that dri is an important regulator of the late development of longitudinal glia...

Research Grants12

  1. HOW DOES VND INTEGRATE POSITIONAL INFORMATION?
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2003
    ..These studies address the structure and function of vnd, a critical regulator of early neuronal development, and may serve as a prototype for vertebrate vnd-like genes. ..
  2. Pancreas-specific primary regulatory targets of Nkx2.2
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2004
    ..2 target genes. This knowledge may be highly instructive in defining those regulatory networks required for beta islet specification. ..
  3. Genetic Analysis of Heavy Metals Neurotoxicity
    Fen Biao Gao; Fiscal Year: 2005
    ....
  4. Animal Models For Studying Angelman Syndrome, A Developmental Brain Disorder
    Fen Biao Gao; Fiscal Year: 2008
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page J Description, [unreadable] [unreadable]..
  5. Palmitoyl Protein Thioesterases in Neural Development
    Quynh Chu LaGraff; Fiscal Year: 2003
    ..Such information may provide insight into the mechanisms of pathogenesis by identifying potential elements that are compromised in Batten Diseases. ..
  6. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  7. Pruning of Motor Neuronal Arbors
    Joyce Fernandes; Fiscal Year: 2003
    ..These studies will have implications for better understanding the neurodevelopmental basis of diseases such as epilepsy, schizophrenia and Rett's syndrome, where pruning is thought to be defective. ..
  8. Axon stabilization: A role for glia in patterning adult innervation in Drosophila
    Joyce Fernandes; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  9. NEUROLOGICAL FUNCTION OF FRAGILE X GENE IN DROSOPHILA
    Kendal Broadie; Fiscal Year: 2006
    ..Specific Aim 3 will search for novel dFXR interacting genes with a genetic enhancer / suppressor screening and microarray technology. This application therefore complements and extends the parallel studies on mammalian systems. ..
  10. Synaptic Mechanisms in Drosophila Neurodegeneration
    Kendal Broadie; Fiscal Year: 2009
    ..abstract_text> ..
  11. GENETIC ANALYSIS OF SYNAPSE FORMATION AND FUNCTION
    Kendal Broadie; Fiscal Year: 2010
    ..These aims will include confocal and electron microscopy imaging, synaptic electrophysiological recording and extensive molecular genetic studies. We will continue screens for synaptogenesis mutants. ..