Genomes and Genes
Gene Symbol: futsch
Description: CG34387 gene product from transcript CG34387-RF
Alias: 22C10, 22C10/FUTSCH, 22C20, 22c10, CG14772, CG3064, CG34387, Dmel\CG34387, Dmel_CG14772, Dmel_CG3064, EG:49E4.1, FUTSCH, Futch, Futsch, MAP-IB, MAP1B, MAb22C10, Mab 22C10, Mab22C10, Mab22c10, Map-1B, Map1B, Olk, lincRNA.936, mAb 22C10, mAb-22C10, mAb22C10, mAb22c10, map1b, olk, ssC10, CG34387 gene product from transcript CG34387-RF, CG34387-PC, CG34387-PE, CG34387-PF, futch, futsch-PC, futsch-PE, futsch-PF, omb-like
Species: fruit fly
Publications142 found, 100 shown here
- Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and functionY Q Zhang
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
Cell 107:591-603. 2001..These phenotypes mimic those observed in mutants of microtubule-associated Futsch. Immunoprecipitation of dFXR shows association with futsch mRNA, and Western analyses demonstrate that dFXR ..
- The glial cell undergoes apoptosis in the microchaete lineage of DrosophilaPierre Fichelson
UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
Development 130:123-33. 2003..Finally, we present evidences showing that glial cells are committed to apoptosis independently of gcm and prospero expression. We suggest that apoptosis is triggered by a cell autonomous mechanism...
- Pruning of motor neuron branches establishes the DLM innervation pattern in DrosophilaSarita Hebbar
Department of Zoology, Miami University, Oxford, Ohio 45056, USA
J Neurobiol 60:499-516. 2004..Our results demonstrate that electrical activity regulates the patterning of DLM innervation during metamorphosis...
- A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain geneG Gregory Neely
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
Cell 143:628-38. 2010..Intriguingly, in α2δ3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing...
- The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiationMary Packard
Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
Cell 111:319-30. 2002..We suggest that Wg signals the coordinated development of pre- and postsynaptic compartments...
- Dynactin is necessary for synapse stabilizationBenjamin A Eaton
Department of Biochemistry and Biophysics, San Francisco, California 94143, USA
Neuron 34:729-41. 2002..Our data suggests that dynactin functions locally within the presynaptic arbor to promote synapse stability...
- The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formationPetra I zur Lage
The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
Development 130:4683-93. 2003..This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes...
- Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal developmentT Hummel
Institut fur Neurobiologie, Universitat Munster, Germany
Neuron 26:357-70. 2000Here we report the description of the Drosophila gene futsch, which encodes a protein recognized by the monoclonal antibody 22C10 that has been widely used to visualize neuronal morphology and axonal projections...
- Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in DrosophilaZhefeng Gong
Biology Department, University of Virginia, Charlottesville, Virginia 22904, USA
J Neurosci 24:9059-66. 2004..A functional green fluorescence protein-IAV fusion protein shows that the channel is restricted to the proximal cilium, constraining models for channel activation...
- Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiationRaphaelle Dubruille
Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 5534, Universite Claude Bernard Lyon 1, 69622 Villeurbanne, France
Development 129:5487-98. 2002..These results identify Rfx as an essential regulator of ciliated sensory neuron differentiation in Drosophila...
- Formin-dependent synaptic growth: evidence that Dlar signals via Diaphanous to modulate synaptic actin and dynamic pioneer microtubulesCatherine Pawson
Department of Biochemistry and Biophysics, Programs in Neuroscience and Cell Biology, University of California, San Francisco, San Francisco, California 94158 2822, USA
J Neurosci 28:11111-23. 2008..within the NMJ that are distinct from the bundled core of microtubules identified by the MAP1b-like protein Futsch. Defects in both synaptic actin and dynamic pioneer microtubules are correlated with impaired synaptic growth in ..
- CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X proteinAnnette Schenck
Department of Molecular Pathology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Boite Postale 10142, 67404 Illkirch, Cedex, France
Neuron 38:887-98. 2003..CYFIP interacts biochemically and genetically with dFMR1 and dRac1. Finally, CYFIP acts as a dRac1 effector that antagonizes FMR1 function, providing a bridge between signal-dependent cytoskeleton remodeling and translation...
- cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organsS E Goulding
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, United Kingdom
Dev Biol 221:120-31. 2000..Moreover, in prospero mutants, in which axon and dendrite outgrowth is defective, cato is strongly derepressed in the developing CNS...
- An IFT-A protein is required to delimit functionally distinct zones in mechanosensory ciliaEugene Lee
Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794, USA
Curr Biol 18:1899-906. 2008..We describe novel structural and functional roles for IFT-A proteins in chordotonal organs, insect mechanosensory organs with cilia that are both sensory and motile...
- The Drosophila Ral GTPase regulates developmental cell shape changes through the Jun NH(2)-terminal kinase pathwayK Sawamoto
Division of Neuroanatomy, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
J Cell Biol 146:361-72. 1999..These results indicate that DRal regulates developmental cell shape changes through the JNK pathway...
- amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozengeS E Goulding
Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
Neuron 25:69-78. 2000..We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS...
- spalt-dependent switching between two cell fates that are induced by the Drosophila EGF receptorP R Elstob
Medical Research Council, National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK
Development 128:723-32. 2001..Together, these studies help to explain how one generic signaling pathway can trigger the differentiation of two distinct cell types...
- Tramtrack69 interacts with the dMi-2 subunit of the Drosophila NuRD chromatin remodelling complexC M Murawsky
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
EMBO Rep 2:1089-94. 2001..We also demonstrate that dMi-2 and Ttk interact genetically, indicating a functional interaction in vivo. We propose that Ttk69 represses some target genes by remodelling chromatin structure through the recruitment of the dNuRD complex...
- Roundabout 2 regulates migration of sensory neurons by signaling in transRachel Kraut
Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
Curr Biol 14:1319-29. 2004..The development of Drosophila embryonic sense organs provides a neuronal migration paradigm where the in vivo roles of Slit and Robo can be assayed using genetics...
- Drosophila spastin regulates synaptic microtubule networks and is required for normal motor functionNina Tang Sherwood
Broad Center, Division of Biology, California Institute of Technology Pasadena, California, USA
PLoS Biol 2:e429. 2004....
- Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/MintJames Ashley
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
J Neurosci 25:5943-55. 2005..These results provide a novel mechanism by which cell adhesion molecules are regulated and provide fresh insights into the normal operation of APP during synapse development...
- Drosophila Bcl-2 proteins participate in stress-induced apoptosis, but are not required for normal developmentEvgueni A Sevrioukov
Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California 92697, USA
Genesis 45:184-93. 2007..Our results demonstrate that developmental PCD regulation in the fly does not rely upon the Bcl-2 proteins, but that they provide an added layer of protection in the apoptotic response to stress...
- Organization and function of the blood-brain barrier in DrosophilaTobias Stork
Institut fur Neurobiologie, Universitat Munster, D 48149 Münster Germany
J Neurosci 28:587-97. 2008....
- split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryoB Kuang
Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville TN 37232 0295, USA
Development 127:1517-29. 2000..We propose that Spen proteins regulate the expression of key effectors of signaling pathways required to specify neuronal cell fate and morphology...
- The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous systemM L Huang
Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
Neuron 25:57-67. 2000..Amos interacts with the ubiquitously expressed Daughter-less protein in vivo and in vitro. Our final misexpression experiments suggest that a domain located outside the DNA-binding domain of Amos determines the MD neuronal specificity...
- Highwire, rpm-1, and futsch: balancing synaptic growth and stabilityQ Chang
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Neuron 26:287-90. 2000
- Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteinsM Aguilera
Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002J, Spain
Genetics 155:1231-44. 2000..In addition to ARI homologues, the RBR signature is also found in the Parkinson-disease-related protein Parkin adjacent to an ubiquitin-like domain, suggesting that the study of this mechanism could be relevant for human pathology...
- Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaicsT P Newsome
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Development 127:851-60. 2000..Rather, we suggest that PTP69D plays a permissive role, perhaps reducing the adhesion of R1-R6 and R7 growth cones to the pioneer R8 axon so that they can respond independently to their specific targeting cues...
- Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signallingN M White
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
Development 127:1681-9. 2000..Our results strongly suggest that Atonal regulates signalling and other properties of R8 precursors...
- The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organizationT Hummel
Institut fur Neurobiologie, Universitat Munster, D 48149 Munster, Germany
Genes Dev 14:863-73. 2000..In addition, the kette mutant phenotype can be partially rescued by expression of an activated DRAC1 transgene. Our data suggest an important role of the HEM-2 protein in cytoskeletal organization during axonal pathfinding...
- Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growthJ Roos
Dept Biochemistry and Biophysics, University of California, San Francisco 94143, USA
Neuron 26:371-82. 2000We present evidence that Futsch, a novel protein with MAP1B homology, controls synaptic growth at the Drosophila neuromuscularjunction through the regulation of the synaptic microtubule cytoskeleton...
- split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cellsF Chen
Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
Curr Biol 10:943-6. 2000..Therefore, spen encodes a positively acting component of the DER/Ras signaling pathway...
- Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in DrosophilaR Nolo
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 102:349-62. 2000..Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs...
- Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signalingS Ben-Yaacov
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
J Cell Biol 152:1-13. 2001..The nature of the Wsp mutant phenotypes, coupled with genetic interaction studies, identifies an essential role for Wsp in lineage decisions mediated by the Notch signaling pathway...
- Drosophila regulatory factor X is an embryonic type I sensory neuron marker also expressed in spermatids and in the brain of DrosophilaC Vandaele
Centre de Génétique Moléculaire et Cellulaire U M R 5534, Laboratoire des Mécanismes Moléculaires et Cellulaires du Développement, Universite Claude Bernard Lyon I, 43, Boulevard du 11 Novembre 1918, F 69622 Villeurbanne, France
Mech Dev 103:159-62. 2001..In addition, dRFX is also detected in the brain throughout development and in spermatids in adult flies...
- Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progressionClaas A Meyer
Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
Development 129:319-28. 2002..The dacapo regulatory region includes many independent cis-regulatory elements. The elements that control epidermal expression integrate developmental cues that time the arrest of cell proliferation...
- The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and functionGuillermo Marques
The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
Neuron 33:529-43. 2002..These results reveal a novel role for BMP signaling in regulating Drosophila neuromuscular junction synapse assembly and activity and may indicate that similar pathways could govern vertebrate synapse development...
- Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesisKarin Dumstrei
Department of Molecular Cell and Developmental Biology, University of California Los Angeles, 90095, USA
Development 129:3983-94. 2002..Finally, EGFR can be co-immunoprecipitated with anti-DE-cadherin and anti-Armadillo antibodies from embryonic protein extracts. We propose that EGFR signaling plays a role in morphogenesis by modulating cell adhesion...
- Different levels of the homeodomain protein cut regulate distinct dendrite branching patterns of Drosophila multidendritic neuronsWesley B Grueber
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Room U226, San Francisco, CA 94143, USA
Cell 112:805-18. 2003..Thus, different levels of a homeoprotein can regulate distinct patterns of dendrite branching...
- Novel isoforms of Dlg are fundamental for neuronal development in DrosophilaCarolina Mendoza
Programa de Fisiologia y Biofisica, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile 6530499
J Neurosci 23:2093-101. 2003..During embryonic development, proteins that include the S97N domain are essential for proper neuronal differentiation and organization, acting through mechanisms that may include the adequate localization of cell fate determinants...
- Even-skipped, acting as a repressor, regulates axonal projections in DrosophilaMiki Fujioka
Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
Development 130:5385-400. 2003..Finally, homologues of Eve from diverse species were able to rescue the eve mutant phenotype, indicating conservation of both targeting and repression functions in the nervous system...
- Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not spermYoung Goo Han
Graduate Program in Genetics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Curr Biol 13:1679-86. 2003..The nompB gene is here shown to encode an IFT protein. Its mutant phenotypes reveal the consequences of an IFT defect in an insect...
- Initial state of the Drosophila eye before dorsoventral specification is equivalent to ventralAmit Singh
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Development 130:6351-60. 2003..Therefore, we propose that early state of the eye prior to DV lineage restriction is equivalent to ventral and requires L and Ser gene function...
- A conserved developmental program for sensory organ formation in Drosophila melanogasterNao Niwa
Division of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
Nat Genet 36:293-7. 2004..Our findings strongly suggest that various sensory organs evolved from an ato-dependent protosensory organ through segment specification by ey and Hox genes...
- A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversityEric C Lai
Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
Dev Biol 269:1-17. 2004..We propose that most Drosophila sensory organs are built from an archetypal lineage, and we speculate about how this stereotyped pattern of cell divisions may have been built during evolution...
- New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutantsCatalina Ruiz-Canada
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 USA
Neuron 42:567-80. 2004..At the presynapse, aPKC regulates the stability of MTs by promoting the association of the MAP1Brelated protein Futsch to MTs...
- Prospero maintains the mitotic potential of glial precursors enabling them to respond to neuronsRachel L Griffiths
NeuroDevelopment Group, Department of Genetics, University of Cambridge, Cambridge, UK
EMBO J 23:2440-50. 2004..This enables prospero-expressing cells alone to divide further upon elimination of neurons and to adjust glial number to axons during development...
- Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosisTong Wey Koh
Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Neuron 43:193-205. 2004..Our data suggest that Dap160, like dynamin, is involved in synaptic vesicle retrieval at active and periactive zones...
- Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growthBruno Marie
Department of Biochemistry and Biophysics, 1550 4th Street, GDBS Fourth Floor North, University of California, San Francisco, 94143, USA
Neuron 43:207-19. 2004..We present a model in which Dap160 scaffolds both endocytic machinery and essential synaptic signaling systems to the periactive zone to coordinately control structural and functional synapse development...
- Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in DrosophilaBénédicte Franco
Laboratoire de Génomique Fonctionnelle, Unité Propre de Recherche Centre National de la Recherche Scientifique 2580, 34094 Montpellier Cedex 5, France
J Neurosci 24:6573-7. 2004..Finally, we show that Sgg controlled the microtubule cytoskeleton dynamics in the motoneuron and that Futsch, a microtubule-associated protein, was required for Shaggy function on synaptic growth.
- The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sitesLynn M Powell
Division of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, United Kingdom
Mol Cell Biol 24:9517-26. 2004..While the latter finding shows that enhancer context is also important in defining how proneural proteins interact with these sites, it is clear that differential utilization of DNA binding sites underlies proneural protein specificity...
- EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulationPetra I zur Lage
Division of Biomedical Sciences, Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
Dev Cell 7:687-96. 2004..This exemplifies a simple and general mechanism for regulating the transition from competence to cell fate commitment whereby a cell signal directly targets the autoregulation of a selector gene...
- Genetic analysis of an overlapping functional requirement for L1- and NCAM-type proteins during sensory axon guidance in DrosophilaLars V Kristiansen
Instituto de Neurociencias CSIC UMH, Universidad Miguel Hernandez, Sant Joan d Alacant, 03550 Spain
Mol Cell Neurosci 28:141-52. 2005..Moreover, our findings demonstrate that this functionally redundant specificity to mediate axon guidance has been conserved in their vertebrate homologs, L1-CAM and NCAM...
- Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in DrosophilaAlexandre Bettencourt Da Cruz
CROET Oregon Health and Science University, Portland, OR 97239, USA
Mol Biol Cell 16:2433-42. 2005..Here we show that Futsch, the fly homolog of MAP1B, is involved in progressive neurodegeneration...
- Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesiclesKyle E Miller
Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Biol 15:684-9. 2005..It suggests the synaptic strength and morphology defects linked to Liprin-alpha may in part be due to a failure in the delivery of synaptic-vesicle precursors...
- Presynaptic spectrin is essential for synapse stabilizationJan Pielage
Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
Curr Biol 15:918-28. 2005..Precise neural circuitry is established and maintained through a regulated balance of synapse stabilization and disassembly. Currently, little is known about the molecular mechanisms that specify synapse stability versus disassembly...
- Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in DrosophilaJose Bessa
Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide Consejo Superior de Investigaciones Científicas, Seville, 41013, Spain
Development 132:5011-20. 2005..Under these conditions, though, terminal eye differentiation proceeds only if tsh expression is transient...
- Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIPBulent Ataman
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
Proc Natl Acad Sci U S A 103:7841-6. 2006..These results provide a mechanism by which DFz2 is transported from the postsynaptic membrane to the postsynaptic nucleus during synapse formation and implicate dGRIP as an essential molecule in the transport of this signal...
- The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junctionNatasha M Viquez
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 26:9293-303. 2006..Hence, wrd promotes the function of PP2A and is required for normal cytoskeletal organization, synaptic growth, and synaptic function at the Drosophila NMJ...
- Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amosEimear E Holohan
Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
BMC Dev Biol 6:53. 2006..The control of these phases and the transition between them appear to be central to the mechanism of neurogenesis. We present the first investigation of the regulation of the proneural gene, amos...
- Causative role of oxidative stress in a Drosophila model of Friedreich ataxiaJose V Llorens
Departament de Genetica, Universitat de Valencia, Carrer Doctor Moliner 50, 46100 Burjassot, Valencia, Spain
FASEB J 21:333-44. 2007..We propose that in FA, the oxidative mediated inactivation of aconitase, which occurs normally during the aging process, is enhanced due to the lack of frataxin...
- Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubulesXinnan Wang
Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK
Nat Neurosci 10:177-85. 2007....
- Circadian changes in Drosophila motor terminalsKerstin I Mehnert
Zoology Department, Stockholm University, Stockholm, Sweden
Dev Neurobiol 67:415-21. 2007..These unexpected results reveal further circadian as well as nonclock related pleiotropic effects for these classic behavioral mutants...
- A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transportEunju Pack-Chung
Program in Neurobiology, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Neurosci 10:980-9. 2007..Our data thus indicate that Imac transports components required for synaptic maturation and provide insight into presynaptic maturation as a process that can be differentiated from axon outgrowth and targeting...
- A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural developmentAmir Orian
Division of Basic Sciences, Genomic Resource, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 104:15771-6. 2007..Our results suggest that the dMyc-Groucho complex defines a previously undescribed mechanism of Myc function and may serve as the transcriptional unit that integrates EGF and Notch inputs to regulate early neuronal development...
- Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shapeShiho Jinushi-Nakao
RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
Neuron 56:963-78. 2007..Hence, this study gives significant general insight into how multiple transcription factors combine to control class-specific dendritic arbor morphology through controlling different aspects of the cytoskeleton...
- MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage siteBeiyan Zou
Department of Biology, Center for Molecular and Cellular Neuroscience, and Intercollege Graduate Program in Genetics, 201 Life Sciences Building, Pennsylvania State University, University Park, PA 16802, USA
Biochem J 414:63-71. 2008..MAP1 function in Drosophila appears to be fulfilled by a single gene, futsch. Although the futsch gene product is known to share several important functional properties with mammalian MAP1s, ..
- A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesionJan Pielage
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158 2822, USA
Neuron 58:195-209. 2008..We propose that a presynaptic Ank2-L lattice links synaptic membrane proteins and spectrin to the underlying microtubule cytoskeleton to organize and stabilize the presynaptic terminal...
- Drosophila ankyrin 2 is required for synaptic stabilityIris Koch
Max Planck Institute for Developmental Biology, Department III Genetics, Spemannstrasse 35, 72076 Tubingen, Germany
Neuron 58:210-22. 2008..Interestingly, Ank2 functions downstream of spectrin in the anchorage of synaptic microtubules, providing the cytoskeletal scaffold that is essential for synaptic stability...
- A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanismAnuradha Ratnaparkhi
Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 3:e2334. 2008..This new fly model of ALS, with its robust pathological phenotypes, should for the first time allow the power of unbiased screens in Drosophila to be applied to study of motor neuron diseases...
- Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junctionClaudia Miech
F M Kirby Neurobiology Center, Children s Hospital, Boston, Massachusetts 02115, USA
J Neurosci 28:10875-84. 2008....
- Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neuronsMari Palgi
Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland
Proc Natl Acad Sci U S A 106:2429-34. 2009..The rescue experiments confirm DmMANF as a functional ortholog of the human MANF gene thus opening the window for comparative studies of this protein family with potential for the treatment of Parkinson's disease...
- Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formationShan Jin
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Development 136:1571-81. 2009..As defective microtubules are implicated in many neurological and developmental diseases, our work on TBCE may offer novel insights into their basis...
- Genomic mapping and expression patterns of C380, OK6 and D42 enhancer trap lines in the larval nervous system of DrosophilaSubhabrata Sanyal
Department of Cell Biology, Emory University of Medicine, Room No 444, 615 ichael Street, NE, Atlanta, GA 30322, USA
Gene Expr Patterns 9:371-80. 2009..three P-element transposon insertion, C380, (BG380), OK6, and D42, shows that these insertions lie upstream of the futsch, Rapgap 1 and toll-6 gene, respectively ...
- PP2A and GSK-3beta act antagonistically to regulate active zone developmentNatasha M Viquez
Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 29:11484-94. 2009..These data suggest that PP2A and GSK-3beta function antagonistically to control active zone development, providing a potential mechanism for regulating synaptic efficacy at a single release site...
- On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineagesGerald Udolph
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Singapore
Dev Biol 336:156-68. 2009..Thus, there is differential requirement for insc for cell fate specification depending on the stage of lineage progression of NBs...
- Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeletonCatherine M Massaro
Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
J Cell Biol 187:101-17. 2009....
- The function and regulation of the bHLH gene, cato, in Drosophila neurogenesisPetra I zur Lage
Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK
BMC Dev Biol 10:34. 2010..cousin of atonal (cato) encodes one such factor that is expressed widely in the developing sensory nervous system of Drosophila. However, nothing definitive was known of its function owing to the lack of specific mutations...
- DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organizationJoost Schulte
Department of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, The Picower Institute for Learning and Memory, Cambridge, Massachusetts 02139, USA
J Neurosci 30:5189-203. 2010..These findings suggest a novel role for Phocein proteins in the regulation of axonal transport, neurite elongation, synapse formation, and microtubule organization...
- The role of the TRP channel NompC in Drosophila larval and adult locomotionLi E Cheng
Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA
Neuron 67:373-80. 2010..Taken together, our findings suggest that NompC mediates proprioception in locomotion and support its role as a mechanosensitive channel...
- Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injuryXin Xiong
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
J Cell Biol 191:211-23. 2010..Our data suggest that the regulation of Wnd protein turnover by Hiw can function as a damage surveillance mechanism for responding to axonal injury...
- LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junctionSeongsoo Lee
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosci 30:16959-69. 2010..At the presynapse, LRRK2 phosphorylates and negatively regulates the microtubule (MT)-binding protein Futsch. These results implicate synaptic dysfunction caused by deregulated protein synthesis and aberrant MT dynamics in ..
- The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neuronsSebastian Cachero
Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom
PLoS Biol 9:e1000568. 2011..In addition, it provides a paradigm for how transcriptional regulation may modulate the ciliogenesis pathway to give rise to structurally and functionally specialised ciliary dendrites...
- Stathmin is required for stability of the Drosophila neuromuscular junctionEthan R Graf
Department of Biology and Neuroscience Program, Amherst College, Amherst, Massachusetts 01002, USA
J Neurosci 31:15026-34. 2011....
- Amyloid precursor proteins are protective in Drosophila models of progressive neurodegenerationJill S Wentzell
Center for Research on Occupational and Environmental Toxicology, Oregon Health and Sciences University, Portland, OR 97239, USA
Neurobiol Dis 46:78-87. 2012..Because we show protective effects in mutants that affect different genes (AMP-activated protein kinase, MAP1b, rasGAP), we propose that the protective effect is not due to a genetic interaction between APPL and these genes ..
- Transsynaptic coordination of synaptic growth, function, and stability by the L1-type CAM NeuroglianEva Maria Enneking
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
PLoS Biol 11:e1001537. 2013....
- Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexesE C Lai
Department of Biology, Center for Molecular Genetics, University of California San Diego, La Jolla, CA, USA
Development 127:291-306. 2000..These results suggest that Bearded family genes encode a novel class of effectors or modulators of Notch signaling...
- Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in DrosophilaEugenia Villa-Cuesta
Centro de Biologia Molecular Severo Ochoa, CSIC and Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Genetics 163:1403-12. 2003..This ability might be related to the wild-type function of amos in promoting development of large clusters of closely spaced olfactory sensilla...
- Embryonic expression pattern of the Drosophila Kallmann syndrome gene kal-1Davide Andrenacci
Institute of Genetics and Biophysics, A Buzzati Traverso, CNR Via P Castellino 111, 80131 Napoli, Italy
Gene Expr Patterns 5:67-73. 2004..This is the first time that the expression of a kal-1 ortholog has been demonstrated to be sex specific making the kal-1 transcript a useful tool for the study of sex determination in the gonad...
- Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1Akifumi Mizutani
Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
EMBO J 24:3339-51. 2005..Our study thus establishes that Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in SCA1 animals...
- The dorsal-open group gene raw is required for restricted DJNK signaling during closureC L Byars
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA anthea
Development 126:4913-23. 1999..Taken together, our results demonstrate a role for Raw in restriction of epidermal signaling during closure and suggest that this effect may be mediated via the amnioserosa...
- Genes regulating dendritic outgrowth, branching, and routing in DrosophilaF B Gao
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California at San Francisco, San Francisco, California 94143 0725, USA
Genes Dev 13:2549-61. 1999..These findings begin to reveal the molecular mechanisms controlling dendritic morphogenesis...
- The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of DrosophilaB Lilly
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, P O Box 85800, San Diego, CA 92186, USA
Mech Dev 88:195-205. 1999..Our analysis shows that dlim1 has been evolutionarily conserved, however the Drosophila lim1 gene exhibits unique properties that distinguishes it from its vertebrate homologs...
- Glia dictate pioneer axon trajectories in the Drosophila embryonic CNSA Hidalgo
NeuroDevelopment Group, Department of Genetics, University of Cambridge, UK
Development 127:393-402. 2000..Secondly, glia direct the fasciculation and defasciculation of axons, which pattern the pioneer pathways. Together these events are essential for the selective fasciculation of follower axons along the longitudinal pathways...
- Drosophila grain encodes a GATA transcription factor required for cell rearrangement during morphogenesisS Brown
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Development 127:4867-76. 2000..This is the first gene that has been shown to affect epithelial morphogenesis by controlling cell rearrangements, and suggests a novel function for GATA transcription factors...
- Pathfinding by sensory axons in Drosophila: substrates and choice points in early lch5 axon outgrowthK L Harris
School of Biological Sciences, University of New England, Armidale, NSW, Australia
J Neurobiol 48:243-55. 2001..At the second choice point (TP2), the lch5 growth cones make their first contact with other axons and turn ventrally toward the CNS, fasciculating specifically with the motor axons of the ISN...
- Context-dependent utilization of Notch activity in Drosophila glial determinationYoshihiko Umesono
Division of Developmental Genetics, National Institute of Genetics, Department of Genetics, Graduate University for Advanced Studies, Mishima, 411 8540, Japan
Development 129:2391-9. 2002..We present evidence that POU-domain protein Nubbin/PDM-1 is one of the factors that provide such context...
- Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogasterRafael Cantera
Zoology Department, Stockholm University, S 106 91 Stockholm, Sweden
Development 129:5577-86. 2002..Effects on the expression of these genes are persistent but many morphological aspects of the phenotype are transient, leading to the concept of sequential redundancy for stable organisation of the central nervous system...
- The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of DrosophilaHo Juhn Song
Department of Zoology, Oregon State University, Corvallis, Oregon 97331 2914, USA
Genetics 162:1703-24. 2002..Our results suggest that one of fru's sex-nonspecific roles is to regulate the pathfinding ability of axons in the embryonic CNS...
- Transcriptional regulation of glial cell specificationGianluca Ragone
Institut de Génétique et Biologie Moléculaire et Cellulaire, IGBMC CNRS ULP INSERM BP 10142 67404 ILLKIRCH, C U, de Strasbourg, France
Dev Biol 255:138-50. 2003..Both negative and positive regulation are required to control glide/gcm expression, indicating that gliogenesis is actively repressed in some neural lineages...
- The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNSTetyana Shandala
Centre for the Molecular Genetics of Development, Adelaide University, Adelaide SA 5005, Australia
Development 130:1505-13. 2003..This suggests that loco and pros are targets of DRI transcriptional activation in some LG. We conclude that dri is an important regulator of the late development of longitudinal glia...
- HOW DOES VND INTEGRATE POSITIONAL INFORMATION?DERVLA MELLERICK DRESSLER; Fiscal Year: 2003..These studies address the structure and function of vnd, a critical regulator of early neuronal development, and may serve as a prototype for vertebrate vnd-like genes. ..
- Pancreas-specific primary regulatory targets of Nkx2.2DERVLA MELLERICK DRESSLER; Fiscal Year: 2004..2 target genes. This knowledge may be highly instructive in defining those regulatory networks required for beta islet specification. ..
- Genetic Analysis of Heavy Metals NeurotoxicityFen Biao Gao; Fiscal Year: 2005....
- Animal Models For Studying Angelman Syndrome, A Developmental Brain DisorderFen Biao Gao; Fiscal Year: 2008..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page J Description, [unreadable] [unreadable]..
- Palmitoyl Protein Thioesterases in Neural DevelopmentQuynh Chu LaGraff; Fiscal Year: 2003..Such information may provide insight into the mechanisms of pathogenesis by identifying potential elements that are compromised in Batten Diseases. ..
- MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONSChris Doe; Fiscal Year: 2002..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
- Pruning of Motor Neuronal ArborsJoyce Fernandes; Fiscal Year: 2003..These studies will have implications for better understanding the neurodevelopmental basis of diseases such as epilepsy, schizophrenia and Rett's syndrome, where pruning is thought to be defective. ..
- Axon stabilization: A role for glia in patterning adult innervation in DrosophilaJoyce Fernandes; Fiscal Year: 2006..unreadable] [unreadable]..
- NEUROLOGICAL FUNCTION OF FRAGILE X GENE IN DROSOPHILAKendal Broadie; Fiscal Year: 2006..Specific Aim 3 will search for novel dFXR interacting genes with a genetic enhancer / suppressor screening and microarray technology. This application therefore complements and extends the parallel studies on mammalian systems. ..
- Synaptic Mechanisms in Drosophila NeurodegenerationKendal Broadie; Fiscal Year: 2009..abstract_text> ..
- GENETIC ANALYSIS OF SYNAPSE FORMATION AND FUNCTIONKendal Broadie; Fiscal Year: 2010..These aims will include confocal and electron microscopy imaging, synaptic electrophysiological recording and extensive molecular genetic studies. We will continue screens for synaptogenesis mutants. ..