ftz-f1

Summary

Gene Symbol: ftz-f1
Description: ftz transcription factor 1
Alias: BFTZ-F1, CG13378, CG4059, DEP1, DmFTZ-F1, Dmel\CG4059, FIP1, FTZ-F1, FTZ-F1A, FTZ-F1alpha, FTZ-Fl, FTZF1, FTZf1alpha, Ftz-F1, Ftz-f1, NR5A3, alphaFTZ-F1, alphaFTZF1, alphaftz-f1, bFTZ-F1, beta FTZ-F1, beta Ftz-f1, beta-FTZ-F1, beta-Ftz-F1, betaFTZ-F1, betaFTZF1, betaFtz-F1, betaFtz-f1, betaftz-F1, betaftz-f1, betaftzf1, dFTZ-F1alpha, dFtz-F1alpha, dmFTZ-f1, ftz-F1, ftz-f1alpha, ftzf1, l(3)03649, CG4059 gene product from transcript CG4059-RC, CG4059-PA, CG4059-PB, CG4059-PC, CG4059-PD, Ftz interacting protein 1, beta-Ftz transcription factor 1, ftz factor 1, ftz-f1-PA, ftz-f1-PB, ftz-f1-PC, ftz-f1-PD, ftz-transcription factor 1, fushi tarazu transcription factor 1
Species: fruit fly

Top Publications

  1. ncbi Sequential gene activation by ecdysone in Drosophila melanogaster: the hierarchical equivalence of early and early late genes
    F Huet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, CU de Strasbourg, France
    Development 121:1195-204. 1995
  2. pmc Potential role for a FTZ-F1 steroid receptor superfamily member in the control of Drosophila metamorphosis
    G Lavorgna
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:3004-8. 1993
  3. ncbi Flies on steroids--Drosophila metamorphosis and the mechanisms of steroid hormone action
    C S Thummel
    Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
    Trends Genet 12:306-10. 1996
  4. ncbi The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors
    A Guichet
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 385:548-52. 1997
  5. ncbi Coordination of Drosophila metamorphosis by two ecdysone-induced nuclear receptors
    K P White
    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 276:114-7. 1997
  6. ncbi Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis
    G T Lam
    Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
    Development 124:1757-69. 1997
  7. pmc Ligand binding was acquired during evolution of nuclear receptors
    H Escriva
    Institut National de la Santé et de la Recherche Médicale U167 Relations Hôte Parasite et Stratégies Vaccinales, Institut Pasteur de Lille, 1 rue Calmette, 59019, Lille Cedex, France
    Proc Natl Acad Sci U S A 94:6803-8. 1997
  8. ncbi Dueling orphans--interacting nuclear receptors coordinate Drosophila metamorphosis
    C S Thummel
    Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
    Bioessays 19:669-72. 1997
  9. ncbi Temporal regulation of the mid-prepupal gene FTZ-F1: DHR3 early late gene product is one of the plural positive regulators
    Y Kageyama
    Department of Genetics, The Graduate University for Advanced Studies, Mishima, Japan
    Genes Cells 2:559-69. 1997
  10. ncbi The Drosophila beta FTZ-F1 orphan nuclear receptor provides competence for stage-specific responses to the steroid hormone ecdysone
    J Broadus
    Howard Hughes Medical Institute, Salt Lake City, Utah 84112, USA
    Mol Cell 3:143-9. 1999

Research Grants

Scientific Experts

  • CARL THUMMEL
  • Susan E Fahrbach
  • Ana Boulanger
  • Argyris Papantonis
  • Nadezhda E Vorobyeva
  • Kirst King-Jones
  • Margrit Schubiger
  • M Mannervik
  • G Richards
  • Udo Hacker
  • Ana Talamillo
  • E H Baehrecke
  • M D Biggin
  • Geanette Lam
  • Hitoshi Ueda
  • Kazutaka Akagi
  • Arash Bashirullah
  • Jinsong Zhu
  • Henry M Krause
  • Barbara N Borsos
  • Yijie Li
  • Sarah D Neuman
  • Craig T Woodard
  • E B Brown
  • Susumu Hirose
  • Moustafa Sarhan
  • H Ueda
  • Y Yu
  • Dana Gancz
  • Nichole D Bond
  • C Y Lee
  • Meng Li
  • Lucía Cáceres
  • Ana Citlali Gradilla
  • Anne Françoise Ruaud
  • Víctor A Francis
  • Yanhui Xiang
  • Amanda R Ritter
  • Jan A van der Knaap
  • Lei Wang
  • L Pick
  • Tatiana Kozlova
  • Hui Ying Hou
  • Aleksandar S Necakov
  • Matheus S Lecci
  • Yasuo Agawa
  • Christine J Vanderzwan-Butler
  • Leslie Pick
  • Xiaoping Sun
  • Fatih Akdemir
  • Laura Palanker
  • Heidi M Sampson
  • Zoé E Kilpatrick
  • Jeff Reinking
  • J P Parvy
  • Yasunari Kayashima
  • Ulrike Löhr
  • W Han
  • S Hirose
  • Damali N Martin
  • G Lam
  • Julie Gates
  • C Jiang
  • M Yussa
  • Haruka Nishida
  • Cheryl C Hsia
  • Tina M Fortier
  • Abdel Rahman S Sultan
  • Azusa Koie
  • Takumi Nakayama
  • Imre M Boros
  • Tibor Pankotai
  • Christina Popescu
  • Zoltan Pahi
  • David Kovacs
  • Cheng Yu Lee
  • ERIKA L MATUNIS
  • Michael Bialecki
  • P P D'Avino
  • Haruhisa Kawasaki
  • Robert J Ihry
  • Qing Ma
  • Sheng Zhang
  • Luc Swevers
  • Kelly M Gruetzmacher
  • Christopher M Cherry
  • C Zhu
  • J E Layne
  • A G Jegga
  • S M Rollmann

Detail Information

Publications103 found, 100 shown here

  1. ncbi Sequential gene activation by ecdysone in Drosophila melanogaster: the hierarchical equivalence of early and early late genes
    F Huet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, CU de Strasbourg, France
    Development 121:1195-204. 1995
    ..In vivo the profile of the increase in hormone titre, the sensitivity of different promoters to hormone and the rate of transcript accumulation must contribute to the temporal differences in expression observed between these two classes...
  2. pmc Potential role for a FTZ-F1 steroid receptor superfamily member in the control of Drosophila metamorphosis
    G Lavorgna
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:3004-8. 1993
    ..These results suggest a role for FTZ-F1 as a regulator of insect metamorphosis and underscore the repeated utilization of a regulatory protein for widely separate developmental pathways...
  3. ncbi Flies on steroids--Drosophila metamorphosis and the mechanisms of steroid hormone action
    C S Thummel
    Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
    Trends Genet 12:306-10. 1996
    ..It seems likely that similar hormone-triggered regulatory hierarchies exist in other higher organisms and that Drosophila is providing our first glimpses of the complexities of these gene networks...
  4. ncbi The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors
    A Guichet
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 385:548-52. 1997
    ..This interaction suggests that other nuclear receptor/homeodomain protein interactions maybe important and common in developing organisms...
  5. ncbi Coordination of Drosophila metamorphosis by two ecdysone-induced nuclear receptors
    K P White
    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 276:114-7. 1997
    ..It also induces betaFTZF1, an orphan nuclear receptor that is essential for the appropriate response to the subsequent prepupal pulse of ..
  6. ncbi Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis
    G T Lam
    Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
    Development 124:1757-69. 1997
    ....
  7. pmc Ligand binding was acquired during evolution of nuclear receptors
    H Escriva
    Institut National de la Santé et de la Recherche Médicale U167 Relations Hôte Parasite et Stratégies Vaccinales, Institut Pasteur de Lille, 1 rue Calmette, 59019, Lille Cedex, France
    Proc Natl Acad Sci U S A 94:6803-8. 1997
    ..Strikingly, our results suggest that the ancestral NR was an orphan receptor that acquired ligand-binding ability during subsequent evolution...
  8. ncbi Dueling orphans--interacting nuclear receptors coordinate Drosophila metamorphosis
    C S Thummel
    Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112, USA
    Bioessays 19:669-72. 1997
    ..This study provides a biological function for orphan receptor interactions during development...
  9. ncbi Temporal regulation of the mid-prepupal gene FTZ-F1: DHR3 early late gene product is one of the plural positive regulators
    Y Kageyama
    Department of Genetics, The Graduate University for Advanced Studies, Mishima, Japan
    Genes Cells 2:559-69. 1997
    ..Elucidation of the regulation mechanism of this gene during prepupal period will help our understanding of metamorphosis at a molecular level...
  10. ncbi The Drosophila beta FTZ-F1 orphan nuclear receptor provides competence for stage-specific responses to the steroid hormone ecdysone
    J Broadus
    Howard Hughes Medical Institute, Salt Lake City, Utah 84112, USA
    Mol Cell 3:143-9. 1999
    ..This study define beta FTZ-F1 as an essential competence factor for stage-specific responses to a steroid signal and implicates interplay among nuclear receptors as a mechanism for achieving hormonal competence...
  11. ncbi The RXR ortholog USP suppresses early metamorphic processes in Drosophila in the absence of ecdysteroids
    M Schubiger
    Department of Zoology, University of Washington, Seattle WA 98195, USA
    Development 127:1151-9. 2000
    ..Our observations suggest that silencing by the unliganded EcR/USP receptor and the subsequent release of silencing by moderate steroid levels may play an important role in coordinating early phases of steroid driven development...
  12. ncbi A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis
    C Jiang
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City 84112, USA
    Mol Cell 5:445-55. 2000
    ..This study identifies transcriptional regulators of programmed cell death in Drosophila and provides a direct link between a steroid signal and a programmed cell death response...
  13. ncbi E93 directs steroid-triggered programmed cell death in Drosophila
    C Y Lee
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
    Mol Cell 6:433-43. 2000
    ..Furthermore, expression of E93 is sufficient to induce programmed cell death. We propose that the steroid induction of E93 determines a programmed cell death response during development...
  14. ncbi Temporally restricted expression of transcription factor betaFTZ-F1: significance for embryogenesis, molting and metamorphosis in Drosophila melanogaster
    M Yamada
    Department of Genetics, The Graduate University for Advanced Studies, and Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Development 127:5083-92. 2000
    ..These results suggest that betaFTZ-F1 regulates genes associated with ecdysis and metamorphosis, and that the exact timing of its action in the ecdysone-induced gene cascade is important for proper development...
  15. pmc FTZ-Factor1 and Fushi tarazu interact via conserved nuclear receptor and coactivator motifs
    C J Schwartz
    Banting and Best Department of Medical Research, University of Toronto and C H Best Institute, 112 College Street, Toronto, Ontario, Canada
    EMBO J 20:510-9. 2001
    ..These unexpected findings have important implications for the conserved homologs of the two proteins...
  16. ncbi Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila
    Cheng Yu Lee
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, 20742, USA
    Dev Biol 252:138-48. 2002
    ..Together, these observations indicate that betaFTZ-F1 regulates the timing of hormone-induced cell responses, while E93 functions to specify programmed cell death...
  17. ncbi Orphan nuclear receptor betaFTZ-F1 is required for muscle-driven morphogenetic events at the prepupal-pupal transition in Drosophila melanogaster
    Tina M Fortier
    Department of Biological Sciences, Mount Holyoke College, South Hadley, MA 01075, USA
    Dev Biol 257:153-65. 2003
    ..Our findings indicate that betaFTZ-F1 directs the muscle contraction events that drive the major morphogenetic processes during the prepupal-pupal transition in Drosophila...
  18. ncbi Nuclear receptors--a perspective from Drosophila
    Kirst King-Jones
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, 15 North 2030 East, Room 5100, Salt Lake City, Utah 84112 5331, USA
    Nat Rev Genet 6:311-23. 2005
    ..Here, we review recent breakthroughs in our understanding of D. melanogaster nuclear receptors, and interpret these results in light of findings from their evolutionarily conserved vertebrate homologues...
  19. ncbi A role for betaFTZ-F1 in regulating ecdysteroid titers during post-embryonic development in Drosophila melanogaster
    J P Parvy
    FRE2852 CNRS Protéines Biochimie structurale et fonctionnelle, Groupe Biogenèse des Stéroïdes, Universite P et M Curie, Bat A, Case 29, 7 quai St Bernard, 75252 Paris Cedex 05, France
    Dev Biol 282:84-94. 2005
    ..of two steroidogenic enzymes, Phantom (PHM) and Disembodied (DIB), were shown to be very reduced in ftz transcription factor 1 (ftz-f1) mutant ring gland cells whereas there was no effect of the without children (woc) mutation, ..
  20. ncbi The Drosophila nuclear receptor e75 contains heme and is gas responsive
    Jeff Reinking
    Banting and Best Department of Medical Research, Charles H Best Institute, 112 College Street, Toronto, Ontario, M5G 1L6, Canada
    Cell 122:195-207. 2005
    ..Further, the E75-DHR3 interaction is also regulated by the binding of NO or CO to the heme center, suggesting that E75 may also function as a diatomic gas sensor. Possible mechanisms and roles for these interactions are discussed...
  21. pmc Dynamic regulation of Drosophila nuclear receptor activity in vivo
    Laura Palanker
    Department of Human Genetics, Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112 5331, USA
    Development 133:3549-62. 2006
    ....
  22. pmc Drosophila Blimp-1 is a transient transcriptional repressor that controls timing of the ecdysone-induced developmental pathway
    Yasuo Agawa
    Department of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Mol Cell Biol 27:8739-47. 2007
    ..Furthermore, its prolonged expression results in delay of pupation timing. These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway...
  23. doi Smt3 is required for Drosophila melanogaster metamorphosis
    Ana Talamillo
    Functional Genomics Unit, CIC bioGUNE, Technology Park, Building 801 A, 48160 Derio, Bizkaia, Spain
    Development 135:1659-68. 2008
    ..In summary, our study indicates that Smt3 is required for the ecdysteroid synthesis pathway at the time of puparium formation...
  24. pmc The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos
    Anne Françoise Ruaud
    Department of Human Genetics, University of Utah School of Medicine, 15 N 2030 E Room 2100, Salt Lake City, UT 84112 5330, USA
    Development 137:123-31. 2010
    ..Taken together, these studies define the lethal phenotypes of DHR3 and betaFTZ-F1 mutants, and provide evidence for functional bifurcation in the 20E-responsive transcriptional cascade...
  25. pmc Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75
    Lucía Cáceres
    Banting and Best Department of Medical Research, Department of Molecular Biology, University of Toronto, Ontario, Canada
    Genes Dev 25:1476-85. 2011
    ..Manipulation of these interactions leads to gross alterations in feeding behavior, fat deposition, and developmental timing. These neuroendocrine interactions and consequences appear to be conserved in vertebrates...
  26. doi Insect nuclear receptors
    Susan E Fahrbach
    Department of Biology, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Annu Rev Entomol 57:83-106. 2012
    ..An exciting new technology allows EcR to be used in chimeric, ligand-inducible gene-switch systems with applications in pest management and medicine...
  27. ncbi A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone
    C T Woodard
    Howard Hughes Medical Institute, Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City 84112
    Cell 79:607-15. 1994
    ..These findings indicate that beta FTZ-F1 plays a central role in the prepupal genetic response to ecdysone and provide a molecular mechanism for stage-specific responses to steroid hormones...
  28. pmc Evolution of the nuclear receptor gene superfamily
    V Laudet
    INSERM U186 CNRS URA 1160, Institut Pasteur, Lille, France
    EMBO J 11:1003-13. 1992
    ..These data suggest a complex evolutionary history for nuclear receptor genes in which gene duplication events and swapping between domains of different origins took place...
  29. ncbi crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis
    P P D'Avino
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5331, USA
    Development 125:1733-45. 1998
    ..The genetic criteria described here provide a new direction for identifying regulators of adult tissue development during insect metamorphosis...
  30. pmc Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily
    U Dressel
    Genetisches Institut der Justus Liebig Universitat, D 35392 Giessen, Germany
    Mol Cell Biol 19:3383-94. 1999
    ..These properties, taken together, show that Alien has the characteristics of a corepressor. Thus, Alien represents a member of a novel class of corepressors specific for selected members of the nuclear hormone receptor superfamily...
  31. ncbi Target genes of homeodomain proteins
    M Mannervik
    Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720 3204, USA
    Bioessays 21:267-70. 1999
    ..An alternative view, that most genes are only indirectly affected by homeodomain proteins is also discussed...
  32. ncbi Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter
    G G Préfontaine
    Graduate Program in Biochemistry, University of Ottawa, Loeb Institute for Medical Research, Ottawa Civic Hospital, Ottawa K1Y 4E9, Ontario, Canada
    J Biol Chem 274:26713-9. 1999
    ....
  33. ncbi BetaFTZ-F1 dependent and independent activation of Edg78E, a pupal cuticle gene, during the early metamorphic period in Drosophila melanogaster
    Haruhisa Kawasaki
    Science of the Biotic Environment Course, The United Graduate School of Agricultural Sciences, Iwate University, Morioka 020 8550, Japan
    Dev Growth Differ 44:419-25. 2002
    ..The findings suggest that betaFTZ-F1 is a regulator for temporal gene expression at the onset of metamorphosis, and that complex mechanisms regulate the temporal and spatial regulation of gene expression during metamorphosis...
  34. ncbi Anterior epidermis-specific expression of the cuticle gene EDG84A is controlled by many cis-regulatory elements in Drosophila melanogaster
    Yasunari Kayashima
    Department of Developmental Genetics, National Institute of Genetics, The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Dev Genes Evol 215:545-52. 2005
    ..These results suggest that both high expression level and differential expression are achieved through many cis-regulatory elements...
  35. ncbi The HMG-box protein Lilliputian is required for Runt-dependent activation of the pair-rule gene fushi-tarazu
    Christine J Vanderzwan-Butler
    Department of Biochemistry and Cell Biology and the Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794 5140, USA Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794 5140, USA
    Dev Biol 301:350-60. 2007
    ..Based on these results we suggest that Lilli plays an architectural role in facilitating transcriptional activation that depends both on the target gene and the developmental context...
  36. pmc Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion
    Tatiana Kozlova
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5330, USA
    Dev Dyn 238:701-7. 2009
    ..In contrast, cuticle gene expression is significantly reduced in DHR38(Y214) mutant pupae. These studies define the essential functions of DHR38 and provide a genetic context for further characterization of its roles during development...
  37. doi br regulates the expression of the ecdysone biosynthesis gene npc1
    Yanhui Xiang
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Dev Biol 344:800-8. 2010
    ..These results imply that ecdysone could potentially act through its early response gene br to achieve positive feedback regulation of ecdysone biosynthesis during development...
  38. doi dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling
    Víctor A Francis
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, Germany
    Curr Biol 20:1799-808. 2010
    ..Because no DOR loss-of-function mammalian models are available, we analyze here the in vivo function of DOR by studying flies mutant for Drosophila DOR (dDOR)...
  39. doi ßFTZ-F1 and Matrix metalloproteinase 2 are required for fat-body remodeling in Drosophila
    Nichole D Bond
    School of Life Sciences, University of Nevada, Las Vegas 4505 S Maryland Parkway, Las Vegas, NV 89154, USA
    Dev Biol 360:286-96. 2011
    ..We show that induction of MMP2 expression in the fat body requires 20E signaling, and that MMP2 is necessary and sufficient to induce fat-body remodeling...
  40. doi Genome-wide association mapping of natural variation in odour-guided behaviour in Drosophila
    E B Brown
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH, USA
    Genes Brain Behav 12:503-15. 2013
    ..Our results showed that subtle changes influencing nervous system function can result in marked differences in behaviour. ..
  41. pmc INO80-dependent regression of ecdysone-induced transcriptional responses regulates developmental timing in Drosophila
    Sarah D Neuman
    Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53705 2222, USA Cellular and Molecular Biology Graduate Program, University of Wisconsin Madison, Madison, WI 53705, USA
    Dev Biol 387:229-39. 2014
    ....
  42. pmc Steroid signaling promotes stem cell maintenance in the Drosophila testis
    Yijie Li
    Department of Cell Biology, 725 N Wolfe Street, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 394:129-41. 2014
    ..Thus, although 20E levels are lower in males than females, ecdysone signaling acts through distinct cell types and effectors to ensure both ovarian and testis stem cell maintenance...
  43. doi Acetylations of Ftz-F1 and histone H4K5 are required for the fine-tuning of ecdysone biosynthesis during Drosophila metamorphosis
    Barbara N Borsos
    Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, Hungary
    Dev Biol 404:80-7. 2015
    ....
  44. doi A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster
    Kazutaka Akagi
    The Graduate School of Natural Science and Technology, Okayama University, Okayama, Okayama 700 8530, Japan
    Development 143:2410-6. 2016
    ..Furthermore, our data suggest that a biological advantage results from both the use of a transcriptional repressor for time determination and the association of developmental timing with nutritional status of the organism. ..
  45. ncbi PKC-mediated USP phosphorylation is required for 20E-induced gene expression in the salivary glands of Drosophila melanogaster
    Xiaoping Sun
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Arch Insect Biochem Physiol 62:116-27. 2006
    ..The composite data suggest that PKC-mediated USP phosphorylation is required for 20E-induced gene expression in the salivary glands of Drosophila melanogaster...
  46. pmc Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes
    Jan A van der Knaap
    Department of Biochemistry, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 30:736-44. 2010
    ..These results revealed the cooperation between a biosynthetic enzyme and a ubiquitin protease in developmental gene control by hormone receptors...
  47. pmc Med24 and Mdh2 are required for Drosophila larval salivary gland cell death
    Lei Wang
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5330, USA
    Dev Dyn 239:954-64. 2010
    ..This study identifies novel mechanisms for controlling the destruction of larval tissues during Drosophila metamorphosis and provides new directions for our understanding of steroid-triggered programmed cell death...
  48. doi Sox14 is required for transcriptional and developmental responses to 20-hydroxyecdysone at the onset of drosophila metamorphosis
    Amanda R Ritter
    Department of Poultry Science, The University of Georgia, Athens, Georgia 30602, USA
    Dev Dyn 239:2685-94. 2010
    ..We also show that the Sox14-regulated gene set correlates well with Sox14 expression in a variety of larval and adult tissues. Thus, Sox14 is a critical transcription factor required for 20E signaling at the onset of metamorphosis...
  49. pmc Isoform-specific regulation of a steroid hormone nuclear receptor by an E3 ubiquitin ligase in Drosophila melanogaster
    Ana Citlali Gradilla
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Genetics 189:871-83. 2011
    ..This fine-tuned orchestration by a conserved ubiquitin ligase is required during insect metamorphosis and, likely, in other steroid hormone-controlled processes across species...
  50. pmc Coordinated regulation of niche and stem cell precursors by hormonal signaling
    Dana Gancz
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
    PLoS Biol 9:e1001202. 2011
    ..Similar principles might govern the formation of additional stem cell units during organogenesis...
  51. pmc Scavenger receptors mediate the role of SUMO and Ftz-f1 in Drosophila steroidogenesis
    Ana Talamillo
    CIC bioGUNE, Derio, Bizkaia, Spain
    PLoS Genet 9:e1003473. 2013
    ....
  52. ncbi The Drosophila nuclear receptors: new insight into the actions of nuclear receptors in development
    A E Oro
    Howard Hughes Medical Institute, Gene Expression Lab, La Jolla, California 92186 5800
    Curr Opin Genet Dev 2:269-74. 1992
    ..This suggests that genetic analysis in flies could facilitate the generation of biological models that pertain to complex hormonal responses in development and which are relevant to both vertebrate and invertebrate systems...
  53. ncbi FTZ-F1, a steroid hormone receptor-like protein implicated in the activation of fushi tarazu
    G Lavorgna
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Science 252:848-51. 1991
    ..This finding raises the possibility that a hormonal ligand affects the expression of a homeobox segmentation gene early in embryonic development...
  54. pmc The binding site of a steroid hormone receptor-like protein within the Drosophila Adh adult enhancer is required for high levels of tissue-specific alcohol dehydrogenase expression
    S Ayer
    Department of Biology, University of Rochester, New York 14627
    Mol Cell Biol 12:661-73. 1992
    ..We have characterized four proteins (DEP1 to DEP4), present in Drosophila tissue culture cell nuclear extracts, which bind to this enhancer...
  55. ncbi A sequence-specific DNA-binding protein that activates fushi tarazu segmentation gene expression
    H Ueda
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genes Dev 4:624-35. 1990
    ..The results suggest that FTZ-F1 is a transcriptional activator necessary for the proper expression of the ftz gene...
  56. pmc Identification and purification of a Bombyx mori homologue of FTZ-F1
    H Ueda
    Genetic Stock Center, National Institute of Genetics, Mishima, Japan
    Nucleic Acids Res 18:7229-34. 1990
    ..The mobility of the factor-DNA complex formed in the silk gland extract changes depending on the developmental stages. Purification of BmFTZF1 to an almost homogeneous state reveals that the factor is a 73 kd protein...
  57. ncbi Insect nuclear receptors: a developmental and comparative perspective
    V C Henrich
    Department of Biology, University of North Carolina Greensboro 27412 5001, USA
    Insect Biochem Mol Biol 25:881-97. 1995
    ..As receptor homologues have been identified in other insects, several general ideas concerning insect hormonal regulation have begun to emerge and these will be examined from a comparative point of view...
  58. pmc Drosophila hormone receptor 38: a second partner for Drosophila USP suggests an unexpected role for nuclear receptors of the nerve growth factor-induced protein B type
    J D Sutherland
    Department of Molecular and Cell Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 92:7966-70. 1995
    ..This suggests that DHR38 plays a role in the ecdysone response and that more generally NGFI-B type receptors may be able to function as heterodimers with retinoid X receptor type receptors in regulating transcription...
  59. ncbi Diploidy of Drosophila imaginal cells is maintained by a transcriptional repressor encoded by escargot
    N Fuse
    Graduate University for Advanced Studies, National Institute of Genetics, Shizuoka ken, Japan
    Genes Dev 8:2270-81. 1994
    ..Ectopic expression of esg in the salivary glands inhibits endoreplication of DNA. These results suggest that esg is involved in transcriptional inhibition of genes required for endoreplication...
  60. ncbi Conservation of regulatory elements controlling hairy pair-rule stripe formation
    J A Langeland
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Development 117:585-96. 1993
    ..Other, as yet unidentified, proteins are certain to play a role in stripe activation, presumably acting through other conserved sequence tracts...
  61. pmc Multiple proteins interact with the fushi tarazu proximal enhancer
    W Han
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, New York, New York 10029
    Mol Cell Biol 13:5549-59. 1993
    ....
  62. ncbi FTZ-F1 beta, a novel member of the Drosophila nuclear receptor family
    C K Ohno
    Department of Pathology, Queen s University, Kingston, Ontario, Canada
    Mech Dev 40:13-24. 1993
    ..Furthermore, the identification of FTZ-F1 beta as a nuclear receptor family member suggests that an as yet undiscovered FTZ-F1 beta specific ligand is involved in Drosophila development...
  63. ncbi From embryogenesis to metamorphosis: the regulation and function of Drosophila nuclear receptor superfamily members
    C S Thummel
    Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah, Salt Lake City 84112, USA
    Cell 83:871-7. 1995
  64. pmc Regulation of the EDG84A gene by FTZ-F1 during metamorphosis in Drosophila melanogaster
    T Murata
    Department of Genetics, The Graduate University for Advanced Studies, National Institute of Genetics, Shizuoka ken, Japan
    Mol Cell Biol 16:6509-15. 1996
    ..These results suggest that FTZ-F1 governs expression of the EDG84A gene in conjunction with putative tissue-specific regulators...
  65. ncbi The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz
    Y Yu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 385:552-5. 1997
    ..Cooperative interaction between homeodomain proteins and cofactors of different classes may serve as a general mechanism to increase HOX protein specificity and to broaden the range of target sites they regulate...
  66. ncbi Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene
    B Florence
    Department of Genetics, University of Wisconsin, Madison 53706, USA
    Development 124:839-47. 1997
    ..We also report the existence of a separate negative regulatory element that apparently responds to odd-skipped...
  67. ncbi Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity
    M D Biggin
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 208114, USA
    Development 124:4425-33. 1997
    ..In this 'widespread binding' model, cofactors act mainly by helping to distinguish the way in which homeoproteins regulate targets to which they are already bound...
  68. pmc A binding site for multiple transcriptional activators in the fushi tarazu proximal enhancer is essential for gene expression in vivo
    W Han
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 18:3384-94. 1998
    ..The finding of repeated binding sites for multiple nuclear proteins underscores the high degree of redundancy built into embryonic gene regulatory networks...
  69. ncbi The acquisition of competence to respond to ecdysone in Drosophila is transcript specific
    G Richards
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163 67404 Illkirch Cedex, Strasbourg, France
    Mech Dev 82:131-9. 1999
    ..Furthermore these inhibitors lead to the induction of betaFTZ-F1 and E93 transcripts at levels normally found in prepupal glands. These studies reveal the complexity of the processes underlying the establishment of a hormonal response...
  70. ncbi A double interaction screen identifies positive and negative ftz gene regulators and ftz-interacting proteins
    Y Yu
    The Brookdale Center of the Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mech Dev 83:95-105. 1999
    ..The DIS should be a generally useful method to identify DNA binding transcriptional regulators and protein partners of previously characterized DNA binding proteins...
  71. ncbi The one-to-four rule and paralogues of sex-determining genes
    S Ohno
    Beckman Research Institute of the City of Hope, Duarte, California 91010 3000, USA
    Cell Mol Life Sci 55:824-30. 1999
    ..It is likely that one of them plays a pivotal role in the estrogen-dependent sex-determining mechanism so commonly found among reptiles, amphibians and fish...
  72. ncbi DHR3 is required for the prepupal-pupal transition and differentiation of adult structures during Drosophila metamorphosis
    G Lam
    Howard Hughes Medical Institute, University of Utah, 15 N 2030 E Rm 5100, Salt Lake City, Utah, 84112 5331, USA
    Dev Biol 212:204-16. 1999
    ....
  73. ncbi A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila
    T Li
    Department of Genetics, The University of Georgia, Athens, GA 30602 7223, USA
    Development 127:2897-905. 2000
    ..These results show that EcR mediates ecdysone signaling at multiple developmental stages and implicate EcR in the reorganization of imaginal and larval tissues at the onset of metamorphosis...
  74. ncbi Insect metamorphosis: out with the old, in with the new
    M Buszczak
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    Curr Biol 10:R830-3. 2000
    ..Recent studies suggest that the E93 gene is both necessary and sufficient to target tissues for ecdysone-induced apoptosis...
  75. ncbi Genetic control and evolution of sexually dimorphic characters in Drosophila
    A Kopp
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin Madison, 53706 1596, USA
    Nature 408:553-9. 2000
    ..Pigmentation patterns specified by bab affect mating preferences, suggesting that sexual selection has contributed to the evolution of bab regulation...
  76. ncbi Steroid regulation of programmed cell death during Drosophila development
    E H Baehrecke
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland, MD 20742, USA
    Cell Death Differ 7:1057-62. 2000
    ..This article reviews the current knowledge of steroid signaling and the regulation of programmed cell death during development of Drosophila...
  77. ncbi Sequence and functional properties of Ets genes in the model organism Drosophila
    T Hsu
    Center for Molecular and Structural Biology, Hollings Cancer Center, and Department of Cell Biology and Anatomy, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, South Carolina, SC 29425, USA
    Oncogene 19:6409-16. 2000
    ..The information should be of significant value to the study of related processes in higher organisms due to the growing evidence for the cross species conservation of developmental mechanisms...
  78. ncbi Steroid regulation of autophagic programmed cell death during development
    C Y Lee
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Development 128:1443-55. 2001
    ..In contrast, E93 expression is sufficient to induce the removal of cells by phagocytes in the absence of the H99 genes. These studies indicate that apoptosis and autophagy utilize some common regulatory mechanisms...
  79. pmc Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription
    R Beckstead
    Department of Molecular and Cellular Biology, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 7:753-65. 2001
    ..Bon binds via an LxxLL motif to the AF-2 activation domain present in the ligand binding domain of betaFTZ-F1 and behaves as a transcriptional inhibitor in vivo...
  80. ncbi Steroid-triggered death by autophagy
    C S Thummel
    Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East Room 5100, University of Utah, UT 84112 5331, USA
    Bioessays 23:677-82. 2001
    ..This paper also shows that E93 can direct cell death independently from the known death-inducer genes, defining a novel death pathway in Drosophila...
  81. pmc Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1
    T Suzuki
    Institute for Virus Research, and Graduate School for Biostudies, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 98:12403-8. 2001
    ..might regulate transcription, we analyzed the mode of interaction between the Drosophila orphan receptor FTZ-F1 (NR5A3) and a segmentation gene product Fushi tarazu (FTZ)...
  82. ncbi Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes
    Sheng Zhang
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06535, USA
    Cell 108:45-56. 2002
    ..We propose that Atrophin proteins function as versatile transcriptional corepressors and discuss a model that deregulation of transcription may contribute to the pathogenesis of neurodegeneration...
  83. ncbi Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila
    Michael Bialecki
    Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East, University of Utah, Salt Lake City 84112, USA
    Dev Cell 3:209-20. 2002
    ..We propose that ecdysteroid-induced E75A expression defines a feed-forward pathway that amplifies or maintains the ecdysteroid titer during larval development, ensuring proper temporal progression through the life cycle...
  84. ncbi The BmE75 nuclear receptors function as dominant repressors of the nuclear receptor BmHR3A
    Luc Swevers
    Institute of Biology, National Centre for Scientific Research Demokritos, P O Box 60228, Aghia Paraskevi Attikis, 153 10 Athens, Greece
    J Biol Chem 277:41637-44. 2002
    ..Our data also indicate that the transcriptional activities of BmHR3A and BmE75 are integrated in such a way that activation of RORE-linked target genes depends on the relative expression levels of the two receptor types...
  85. ncbi Evolution of transcription factor function
    Cheryl C Hsia
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Curr Opin Genet Dev 13:199-206. 2003
    ..Interestingly, recent studies provide evidence that changes in transcription factor protein sequence can affect the regulation of only a subset of target genes, even in the same cells of a developing animal...
  86. ncbi rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development
    Julie Gates
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112 5331, USA
    Development 131:25-36. 2004
    ..Furthermore, the dynamic intracellular redistribution of Rig protein suggests that it may act to refine spatial and temporal responses to ecdysone during development...
  87. ncbi Caspases function in autophagic programmed cell death in Drosophila
    Damali N Martin
    Center for Biosystems Research, University of Maryland Biotechnology Institute, and Department of Cell Biology, University of Maryland, College Park, Maryland 20742, USA
    Development 131:275-84. 2004
    ..These studies suggest that aspects of the cytoskeleton may be required for changes in dying salivary glands. Furthermore, caspases are not only used during apoptosis, but also function in the regulation of autophagic cell death...
  88. ncbi Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells
    Zoé E Kilpatrick
    Hanson Institute, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, SA 5000, Australia
    J Biol Chem 280:11981-6. 2005
    ..Combined with previous observations, our results indicate that transcriptional regulation of the components of the core apoptotic machinery plays a key role in hormone-regulated programmed cell death during Drosophila development...
  89. ncbi The ecdysone-induced DHR4 orphan nuclear receptor coordinates growth and maturation in Drosophila
    Kirst King-Jones
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Cell 121:773-84. 2005
    ..We propose that DHR4 coordinates growth and maturation in Drosophila by mediating endocrine responses to the attainment of critical weight during larval development...
  90. ncbi Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death
    Fatih Akdemir
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Development 133:1457-65. 2006
    ....
  91. pmc dTrf2 is required for transcriptional and developmental responses to ecdysone during Drosophila metamorphosis
    Arash Bashirullah
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5330, USA
    Dev Dyn 236:3173-9. 2007
    ..The transcription of key ecdysone-regulated target genes is delayed and reduced in dTrf2 mutants. dTrf2 appears to be required for the proper timing and levels of ecdysone-regulated gene expression required for entry into metamorphosis...
  92. doi Functional and bioinformatics analyses reveal conservation of cis-regulatory elements between sciaridae and drosophilidae
    Matheus S Lecci
    Departamento de Analises Clinicas, Toxicológicas e Bromatológicas DACTB, Faculdade de Ciências Farmacêuticas de Ribeirão Preto FCFRP, Universidade de Sao Paulo USP, Ribeirao Preto, SP, Brazil
    Genesis 46:43-51. 2008
    ....
  93. doi ftz-f1 and Hr39 opposing roles on EcR expression during Drosophila mushroom body neuron remodeling
    Ana Boulanger
    Institute of Human Genetics, CNRS UPR1142, Montpellier, France
    Nat Neurosci 14:37-44. 2011
    ..We found that the ftz-f1 and Hr39 pathway apparently acts independently of TGFβ signaling, suggesting that EcR-B1 is the target of two parallel molecular pathways that act during γ neuron remodeling...
  94. pmc Heterodimer of two bHLH-PAS proteins mediates juvenile hormone-induced gene expression
    Meng Li
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 108:638-43. 2011
    ..Together, the evidence indicates that Met and FISC form a functional complex on the JHRE in the presence of JH and directly activate transcription of JH target genes...
  95. pmc The Drosophila nuclear receptors FTZ-F1 alpha and FTZ-F1 beta compete as monomers for binding to a site in the fushi tarazu gene
    C K Ohno
    Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada
    Mol Cell Biol 14:3166-75. 1994
    ..These data suggest that FTZ-F1 alpha and FTZ-F1 beta likely coregulate common target genes by competition for binding to a 9-bp recognition element...
  96. pmc Activation and repression of Drosophila alcohol dehydrogenase distal transcription by two steroid hormone receptor superfamily members binding to a common response element
    S Ayer
    Department of Biology, University of Rochester, NY 14627
    Nucleic Acids Res 21:1619-27. 1993
    ..Over expression of an alternative DHR39 open reading frame that lacks part of the putative ligand binding domain does not alter Adh expression. In contrast, over expression of FTZ-F1 specifically activates distal Adh expression...
  97. ncbi Cross-talking among Drosophila nuclear receptors at the promiscuous response element of the ng-1 and ng-2 intermolt genes
    S Crispi
    Dipartimento di Genetica, Biologia Generale e Molecolare Università di Napoli, Italia
    J Mol Biol 275:561-74. 1998
    ..Finally, we show that the ng-EcRE can promote functional interactions in vitro as well as in vivo, acting as a transcriptional enhancer able to confer a specific developmental expression profile to a minimal promoter in transgenic flies...
  98. ncbi Drosophila fushi tarazu. a gene on the border of homeotic function
    U Löhr
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Biol 11:1403-12. 2001
    ..If these genes arose from a homeotic ancestor, their functional properties must have changed significantly during the evolution of modern Drosophila...
  99. pmc piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila
    Udo Hacker
    Department of Cell and Molecular Biology, BMC B13, Lund University, 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 100:7720-5. 2003
    ..Our data demonstrate the potential of this technique to facilitate the quest for saturation mutagenesis of the Drosophila genome. The system is Drosophila nonspecific and potentially applicable in a broad spectrum of nonmodel organisms...
  100. pmc The competence factor beta Ftz-F1 potentiates ecdysone receptor activity via recruiting a p160/SRC coactivator
    Jinsong Zhu
    Department of Entomology and Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA
    Mol Cell Biol 26:9402-12. 2006
    ..Thus, our results reveal the molecular basis of competence for the stage-specific 20E response...

Research Grants2

  1. STEROID REGULATION OF PROGRAMMED CELL DEATH
    CARL THUMMEL; Fiscal Year: 2003
    ..In addition, this study will provide insight into the molecular mechanisms by which systemic hormonal signals are refined into stage- and tissue-specific biological responses during development. ..
  2. Mechanisms of Steroid-Triggered Programmed Cell Death
    CARL THUMMEL; Fiscal Year: 2009
    ..Finally, our studies provide a foundation for determining how steroids control cell death in humans, with implications for understanding and treating human disease. ..