fra

Summary

Gene Symbol: fra
Description: frazzled
Alias: CG8581, CT24981, DCC, Dmel\CG8581, Fra, CG8581 gene product from transcript CG8581-RA, CG8581-PA, CG8581-PB, CG8581-PC, DCC/Frazzled, Netrin-receptor, deleted in colorectal cancer, deleted in colorectal carcinoma, fra-PA, fra-PB, fra-PC
Species: fruit fly

Top Publications

  1. pmc Redundant mechanisms for regulation of midline crossing in Drosophila
    Giorgio F Gilestro
    Research Institute of Molecular Pathology, Vienna, Austria
    PLoS ONE 3:e3798. 2008
  2. ncbi Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 103:1033-45. 2000
  3. ncbi Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
    K Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 32:605-17. 2001
  4. pmc A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion
    G J Bashaw
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 155:1117-22. 2001
  5. pmc The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding
    Bader Al-Anzi
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Neural Dev 4:31. 2009
  6. ncbi Comm sorts robo to control axon guidance at the Drosophila midline
    Krystyna Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 110:415-27. 2002
  7. ncbi Constitutively active myosin light chain kinase alters axon guidance decisions in Drosophila embryos
    You Seung Kim
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Dev Biol 249:367-81. 2002
  8. pmc A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance
    Long Yang
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Science 324:944-7. 2009
  9. ncbi Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline
    Marie Pierre Furrer
    Department of Cell and Structural Biology, University of Illinois, 601 South Goodwin Avenue, Urbana, Illinois 61801, USA
    Nat Neurosci 6:223-30. 2003
  10. ncbi Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline
    Xueping Fan
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Neuron 40:113-27. 2003

Research Grants

  1. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
  2. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
  3. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
  4. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
  5. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
  6. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008
  7. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010

Scientific Experts

  • GREG BASHAW
  • YUH N JAN
  • Giorgio F Gilestro
  • M A Seeger
  • Marta Zlatic
  • Yimiao Ou
  • Krishna Bhat
  • Masaki Hiramoto
  • Matthias Landgraf
  • F Huang
  • H J Song
  • Guy Tear
  • Bader Al-Anzi
  • Judith Eisen
  • Mary Packard
  • Stephen Crews
  • Akira Chiba
  • Bharatkumar N Patel
  • Joy N Dorsten
  • David S Garbe
  • Mark F A VanBerkum
  • Wesley B Grueber
  • Juan Pablo Labrador
  • Adrienne VanZomeren-Dohm
  • Ellen Flannery
  • Alex Mauss
  • Willy Joly
  • Marco Tripodi
  • Marie Sophie Cate
  • Naomi Halachmi
  • Hong Long
  • Melissa Pert
  • Cristina Organisti
  • Takashi Suzuki
  • Satoko Hakeda-Suzuki
  • Robert Saint
  • Michael J Murray
  • Gunnar Newquist
  • Natalia Mora
  • Michael P O'Donnell
  • Rosemary Manhire-Heath
  • Irina Hein
  • Katarina Timofeev
  • Wen Lu
  • Irina Kuzina
  • Song Song
  • Rei K Morikawa
  • Benjamin J Matthews
  • Molly Duman-Scheel
  • Shingo Yoshikawa
  • Thomas Kidd
  • John B Thomas
  • Hope A Coleman
  • Christian M von Hilchen
  • Robert A Carrillo
  • Bettina Spitzweck
  • Long Yang
  • David J Brierley
  • Jan Felix Evers
  • Anita Hsouna
  • Iris Salecker
  • Gracie L Andrews
  • Jop Kind
  • Monica M Davis
  • Elena Simionato
  • Gerhard M Technau
  • Barry J Dickson
  • Peter A Kolodziej
  • Nara I Muraro
  • David J Forsthoefel
  • Tereza Kolesnikov
  • Eve Ellen Govek
  • Susanne Onel
  • Carole Chotard
  • Xueping Fan
  • Kevin J Mitchell
  • Samantha Alsbury
  • Atalya Nachman
  • Sangeetha Gajendra
  • Thomas Raabe
  • Marie Pierre Furrer
  • P A Kolodziej
  • Adi Salzberg
  • Ilona C Grunwald Kadow
  • Miao Gan
  • Jessica Couch
  • You Seung Kim
  • Anuradha Ratnaparkhi
  • Krystyna Keleman
  • Sofia Golenkina

Detail Information

Publications87

  1. pmc Redundant mechanisms for regulation of midline crossing in Drosophila
    Giorgio F Gilestro
    Research Institute of Molecular Pathology, Vienna, Austria
    PLoS ONE 3:e3798. 2008
    ..Surprisingly, expression of these modified proteins results in phenotypically normal flies, unveiling a sorting independent mechanism of regulation...
  2. ncbi Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 103:1033-45. 2000
    ..Local cues further refine the lateral position. Together, these long- and short-range guidance cues allow growth cones to select with precision a specific longitudinal pathway...
  3. ncbi Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
    K Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 32:605-17. 2001
    ..Here we report the identification of the Drosophila Unc5 receptor, and show that it is a repulsive Netrin receptor likely to contribute to motor axon guidance...
  4. pmc A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion
    G J Bashaw
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 155:1117-22. 2001
    ..Surprisingly, evidence from genetic, biochemical, and cell culture experiments suggests that the promotion of axon attraction by GEF64C is dependent on the activation of Rho, but not Rac or Cdc42...
  5. pmc The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding
    Bader Al-Anzi
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Neural Dev 4:31. 2009
    ..However, a large number of commissural axons successfully cross the midline even in the complete absence of netrin signaling, indicating the presence of a yet unidentified midline attractant...
  6. ncbi Comm sorts robo to control axon guidance at the Drosophila midline
    Krystyna Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 110:415-27. 2002
    ..Axon traffic at the CNS midline is thus controlled by the intracellular trafficking of the Robo guidance receptor, which in turn depends on the precisely regulated expression of the Comm sorting receptor...
  7. ncbi Constitutively active myosin light chain kinase alters axon guidance decisions in Drosophila embryos
    You Seung Kim
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Dev Biol 249:367-81. 2002
    ..These results confirm that proper pathway formation requires careful regulation of MLCK and/or myosin II activity and suggest that regulation occurs in direct response to attractive and repulsive cues...
  8. pmc A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance
    Long Yang
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Science 324:944-7. 2009
    ..Slit-roundabout repulsion and netrin-deleted in colorectal cancer (DCC) (frazzled) attraction must be tightly regulated to control midline axon guidance in vertebrates ..
  9. ncbi Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline
    Marie Pierre Furrer
    Department of Cell and Structural Biology, University of Illinois, 601 South Goodwin Avenue, Urbana, Illinois 61801, USA
    Nat Neurosci 6:223-30. 2003
    ..Furthermore, we report that each neuron showed a cell-autonomous and independent use of guidance molecules...
  10. ncbi Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline
    Xueping Fan
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Neuron 40:113-27. 2003
    ..These results provide a direct physical link between the Robo receptor and an important cytoskeletal regulatory protein complex and suggest that Rac can function in both attractive and repulsive axon guidance...
  11. ncbi The control of dendrite development
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 40:229-42. 2003
    ..In contrast, the control of dendrite development is still much less well understood. However, recent progress has begun to shed light on the molecular mechanisms that orchestrate dendrite growth, arborization, and guidance...
  12. ncbi Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila
    J E Brenman
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco 94143, USA
    Dev Cell 1:667-77. 2001
    ....
  13. ncbi Dendritic development: lessons from Drosophila and related branches
    Wesley B Grueber
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Box 0725, San Francisco CA 94143, USA
    Curr Opin Neurobiol 14:74-82. 2004
    ..Here, we review some recent advances in our understanding of dendritic development in insects, focusing primarily on insights that have been gained from studies of Drosophila...
  14. pmc Dscam guides embryonic axons by Netrin-dependent and -independent functions
    Gracie L Andrews
    Department of Biology MS 314, University of Nevada, Reno, NV 89557, USA
    Development 135:3839-48. 2008
    ..Netrin and Dscam mutants display dose sensitive interactions, suggesting that Dscam could act as a Netrin receptor. We show using cell overlay assays that Netrin binds to fly and vertebrate Dscam, and that Dscam binds Netrin ..
  15. ncbi Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline
    David S Garbe
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:4325-34. 2007
    The conserved DCC ligand-receptor pair Netrin and Frazzled (Fra) has a well-established role in axon guidance. However, the specific sequence motifs required for orchestrating downstream signaling events are not well understood...
  16. ncbi The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila
    David J Forsthoefel
    The Ohio State University, Department of Molecular Genetics and Center for Molecular Neurobiology, Columbus, OH 43210, USA
    Development 132:1983-94. 2005
    The attractive Netrin receptor Frazzled (Fra), and the signaling molecules Abelson tyrosine kinase (Abl), the guanine nucleotide-exchange factor Trio, and the Abl substrate Enabled (Ena), all regulate axon pathfinding at the Drosophila ..
  17. ncbi Frazzled regulation of myosin II activity in the Drosophila embryonic CNS
    Joy N Dorsten
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Dev Biol 308:120-32. 2007
    Frazzled (Fra) is a chemoattractive guidance receptor regulating the cytoskeletal dynamics underlying growth cone steering at the Drosophila embryonic midline...
  18. ncbi The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in Drosophila
    Juan Pablo Labrador
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 15:1413-9. 2005
    ..using genetics and single-cell mRNA-expression analysis, we show that expression and requirement of different Netrin receptor combinations correlate with distinct dorsal and ventral motor-axon projections in Drosophila...
  19. ncbi The development of neuronal morphology in insects
    Wesley B Grueber
    Department of Physiology and Cellular Biophysics, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Curr Biol 15:R730-8. 2005
    ..We speculate about how and why the actions of these genes might facilitate the diversification of dendritic morphology...
  20. ncbi ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized Netrin
    Masaki Hiramoto
    Department of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Nat Neurosci 9:58-66. 2006
    ..The absence of suppression causes the robo phenotype: longitudinal axons project toward the midline, as if running around a roundabout (rotary)...
  21. ncbi Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila
    David S Garbe
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:3584-92. 2007
    ..and vertebrate systems support the idea that Netrin, secreted by midline cells, signals through DCC (Deleted in Colorectal Carcinoma)/UNC40/Frazzled receptors to attract commissural axons toward and across the midline, whereas Slit ..
  22. ncbi frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance
    P A Kolodziej
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0724, USA
    Cell 87:197-204. 1996
    We have identified a Drosophila member of the deleted in colorectal cancer (DCC) gene family...
  23. ncbi Commissure formation in the embryonic CNS of Drosophila
    T Hummel
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Development 126:771-9. 1999
    ..Here we present evidence that beside the previously known NETRIN/FRAZZLED (DCC) signalling system an additional attractive system(s) is operating in the developing embryonic nervous system of ..
  24. ncbi The netrin receptor frazzled is required in the target for establishment of retinal projections in the Drosophila visual system
    Q Gong
    Laboratory of Developmental Neurogenetics, The Rockefeller University, New York, NY 10021, USA
    Development 126:1451-6. 1999
    ..Our data suggest that Frazzled does not function as a Netrin receptor in attracting retinal fibers to the target; nor does it seem to act as a homotypic cell adhesion molecule...
  25. pmc Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system
    Alex Mauss
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 7:e1000200. 2009
    ..We further propose that sets of connections may be specified, at least to a degree, by global patterning systems that deliver pre- and postsynaptic partner terminals to common "meeting regions."..
  26. ncbi Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs
    M L Winberg
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 93:581-91. 1998
    ..Rather, these growth cones assess the relative balance of attractive and repulsive forces and select their targets based on the combinatorial and simultaneous input of multiple cues...
  27. doi Netrins guide migration of distinct glial cells in the Drosophila embryo
    Christian M von Hilchen
    Institute of Genetics, University of Mainz, Saarstrasse 21, Mainz, Germany
    Development 137:1251-62. 2010
    ..We further show that early Netrin-dependent guidance of LG requires expression of the receptor Frazzled (Fra) already in the precursor cell...
  28. pmc Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map
    David J Brierley
    Medical Research Council MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS Biol 7:e1000199. 2009
    ..of motoneuron dendrites in the leg neuropil is controlled by the midline signalling systems Slit-Robo and Netrin-Fra. These results reveal that dendritic targeting plays a major role in the formation of myotopic maps and suggests ..
  29. ncbi The Drosophila Netrin receptor Frazzled guides axons by controlling Netrin distribution
    M Hiramoto
    Department of Developmental Genetics, National Institute of Genetics, Graduate University for Advanced Studies, Japan
    Nature 406:886-9. 2000
    Netrin is a secreted protein that can act as a chemotropic axon guidance cue. Two classes of Netrin receptor, DCC and UNC-5 (refs 6-9), are required for axon guidance and are thought to mediate Netrin signals in growth cones through ..
  30. pmc Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis
    Marta Zlatic
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 7:e1000135. 2009
    ..Together our findings support the idea that axons are delivered to particular regions of the neuropile by their responses to systems of positional cues in each dimension...
  31. ncbi Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
    G J Bashaw
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 97:917-26. 1999
    Frazzled (Fra) is the DCC-like Netrin receptor in Drosophila that mediates attraction; Roundabout (Robo) is a Slit receptor that mediates repulsion...
  32. pmc Structural homeostasis: compensatory adjustments of dendritic arbor geometry in response to variations of synaptic input
    Marco Tripodi
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 6:e260. 2008
    ..The growing arbor thus counterbalances naturally occurring variations in synaptic density and activity so as to ensure that an appropriate level of input is achieved...
  33. doi Frazzled cytoplasmic P-motifs are differentially required for axon pathway formation in the Drosophila embryonic CNS
    Joy N Dorsten
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, United States
    Int J Dev Neurosci 26:753-61. 2008
    ..However, removal of P3 from Fra does prevent eagle-expressing commissural axons from crossing the midline in the posterior commissure suggesting ..
  34. pmc Equivalent Activities of Repulsive Axon Guidance Receptors
    Hong Long
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    J Neurosci 36:1140-50. 2016
    ....
  35. doi A newly identified type of attachment cell is critical for normal patterning of chordotonal neurons
    Naomi Halachmi
    Department of Genetics, The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa 3109601, Israel
    Dev Biol 411:61-71. 2016
    ....
  36. pmc Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells
    Melissa Pert
    Department of Genetics, University of Melbourne, Vic, 3010, Australia
    Biol Open 4:233-43. 2015
    ..expressed in the visceral mesoderm, the substrate upon which midgut cells migrate, while their receptor frazzled (fra) is expressed in midgut cells...
  37. doi Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance
    Cristina Organisti
    Max Planck Institute of Neurobiology, Sensory Neurogenetics Research Group, Am Klopferspitz 18, Martinsried, 82152, Germany
    Genes Cells 20:50-67. 2015
    ..In Drosophila, commissural axons sense the midline attractants Netrin A and B (Net) through Frazzled (Fra) receptors...
  38. doi Netrin-dependent downregulation of Frazzled/DCC is required for the dissociation of the peripodial epithelium in Drosophila
    Rosemary Manhire-Heath
    Department of Genetics, University of Melbourne, Melbourne, Victoria 3010, Australia
    Nat Commun 4:2790. 2013
    ..promotes the survival of metastasized cells by inhibiting the pro-apoptotic effects of its receptor Deleted in Colorectal Carcinoma (DCC)...
  39. ncbi Cell surface control of the layer specific targeting in the Drosophila visual system
    Satoko Hakeda-Suzuki
    Core Division of Advanced Research, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
    Genes Genet Syst 89:9-15. 2014
    ..Fundamental and comprehensive understanding of the crosstalk of growing axons and target regions in the Drosophila optic lobe will elucidate the general principles applicable to more complex nervous systems...
  40. pmc Blocking apoptotic signaling rescues axon guidance in Netrin mutants
    Gunnar Newquist
    Department of Biology, University of Nevada, Reno, NV 89557, USA
    Cell Rep 3:595-606. 2013
    ..In contrast to the traditional role of Netrin as simply a guidance cue, our results demonstrate that guidance and survival activities may be functionally related...
  41. pmc Src inhibits midline axon crossing independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) receptor tyrosine phosphorylation
    Michael P O'Donnell
    Cell and Molecular Biology Graduate Group and Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:305-14. 2013
    ..family of chemoattractants signal outgrowth and attractive turning of commissural axons through the Deleted in Colorectal Carcinoma (DCC) family of receptors...
  42. doi β amyloid protein precursor-like (Appl) is a Ras1/MAPK-regulated gene required for axonal targeting in Drosophila photoreceptor neurons
    Natalia Mora
    Departament de Genetica, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona IBUB, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Cell Sci 126:53-9. 2013
    ..We also found that zebrafish appb expression increased after ectopic fgfr activation in the neural tube of zebrafish embryos, suggesting a conserved regulatory mechanism...
  43. pmc Niche-associated activation of rac promotes the asymmetric division of Drosophila female germline stem cells
    Wen Lu
    Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, Illinois, United States of America
    PLoS Biol 10:e1001357. 2012
    ..However, given that the BMP signal can be diffusible, it remains unclear how a local extracellular asymmetry is sufficient to result in a robust pattern of asymmetric division...
  44. doi TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance
    Song Song
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 38:1-11. 2011
    ..Over-expression of the Netrin/UNC-6 receptor Frazzled suppresses the guidance defects in trim-9 mutants. Our study reveals an evolutionarily conserved function of TRIM-9 in the UNC-40/Frazzled-mediated UNC-6/Netrin attraction pathway...
  45. pmc Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila
    Marie Sophie Cate
    MRC Centre for Developmental Neurobiology, New Hunts House, King s College, London, SE1 1UL, UK
    Development 143:972-7. 2016
    ..These studies identify a parallel pathway controlling midline guidance in Drosophila and highlight a novel role for Mud potentially acting downstream of Frizzled to aid axon guidance. ..
  46. ncbi The role of the Rho GTPases in neuronal development
    Eve Ellen Govek
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 19:1-49. 2005
    ..This review will focus on the role of the Rho GTPases and their associated signaling molecules throughout neuronal development and discuss how perturbations in Rho GTPase signaling may lead to cognitive disorders...
  47. pmc The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline
    Hope A Coleman
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Development 137:2417-26. 2010
    ..Finally, Kuz activity is required for Robo to recruit its downstream signaling partner, Son of sevenless (Sos). These observations support the model that Kuz-directed cleavage is important for Robo receptor activation...
  48. pmc Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement
    Robert A Carrillo
    Pharmacology Department, Yale School of Medicine, New Haven, CT 06520, USA
    Neuron 68:32-44. 2010
    ..These results indicate a role for patterned electrical activity and presynaptic calcium signaling, acting through CaMKII, in modulating a retrograde signal during the refinement of synaptic connections...
  49. pmc How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS
    Irina Kuzina
    National Institute of Neurological Disorders and Stroke and National Human Genome Research Institute NIH, Bethesda, MD 20892, USA
    Development 138:1839-49. 2011
    ..This propels the axons as they establish the connection between successive segments...
  50. pmc Dscam1-mediated self-avoidance counters netrin-dependent targeting of dendrites in Drosophila
    Benjamin J Matthews
    Department of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Biol 21:1480-7. 2011
    ..counter Drosophila sensory neuron dendritic targeting signals provided by secreted Netrin-B and Frazzled, a netrin receptor. Loss of Dscam1 function resulted in aberrant dendrite accumulation at a Netrin-B-expressing target, whereas ..
  51. pmc A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response
    Monica M Davis
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    Mol Cell Biol 28:4883-95. 2008
    ..We propose that the involvement of DDC in a new pathway involved in Drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria...
  52. pmc Different levels of the Tripartite motif protein, Anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neurons
    Rei K Morikawa
    Department of Cell Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Proc Natl Acad Sci U S A 108:19389-94. 2011
    ..by biochemical and genetic analysis that Asap regulates Netrin signaling, at least in part by linking the Netrin receptor Frazzled to the downstream effector Pico...
  53. pmc Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila
    Katarina Timofeev
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, London, UK
    Neuron 75:80-93. 2012
    ..We propose that provision of localized chemoattractants by intermediate target neurons represents a highly precise strategy to direct axons to a positionally defined layer...
  54. ncbi Axon guidance at the central nervous system midline
    G Tear
    Molecular Neurobiology Group, Guy s Hospital Campus, King s College, London
    Cell Mol Life Sci 55:1365-76. 1999
    ..In this way, axons extend toward or away from the midline and those that do cross change their behaviour to respond to longitudinal signals on the contralateral side...
  55. pmc In the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS
    Joy N Dorsten
    Department of Biological Sciences, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 5:e9822. 2010
    In the Drosophila embryonic nerve cord, the formation of commissures require both the chemoattractive Netrin receptor Frazzled (Fra) and the Abelson (Abl) cytoplasmic tyrosine kinase...
  56. ncbi Slit proteins: key regulators of axon guidance, axonal branching, and cell migration
    K Brose
    Departments of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 0452, USA
    Curr Opin Neurobiol 10:95-102. 2000
    ....
  57. pmc The Drosophila Netrin receptor frazzled/DCC functions as an invasive tumor suppressor
    Adrienne VanZomeren-Dohm
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Raclin Carmichael Hall, 1234 Notre Dame Ave, South Bend, IN 46617, USA
    BMC Dev Biol 11:41. 2011
    Loss of heterozygosity at 18q, which includes the Deleted in Colorectal Cancer (DCC) gene, has been linked to many human cancers. However, it is unclear if loss of DCC is the specific underlying cause of these cancers...
  58. pmc The neuron-enriched splicing pattern of Drosophila erect wing is dependent on the presence of ELAV protein
    S P Koushika
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Mol Cell Biol 20:1836-45. 2000
    ..Additionally, we report that ELAV promotes a neuron-enriched splice isoform of Drosophila armadillo transcript. ELAV, however, is not involved in all neuron-enriched splice events...
  59. ncbi split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo
    B Kuang
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University Medical Center, Nashville TN 37232 0295, USA
    Development 127:1517-29. 2000
    ..We propose that Spen proteins regulate the expression of key effectors of signaling pathways required to specify neuronal cell fate and morphology...
  60. ncbi Attraction versus repulsion: modular receptors make the difference in axon guidance
    M A Seeger
    Department of Molecular Genetics, Ohio State University, Columbus 43210, USA
    Cell 97:821-4. 1999
  61. ncbi Signal transduction underlying growth cone guidance by diffusible factors
    H J Song
    Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Neurobiol 9:355-63. 1999
    ..Furthermore, many diffusible guidance cues appear to share common cytoplasmic signaling pathways...
  62. ncbi Genetic and molecular analyses of motoneuron development
    J S Eisen
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Curr Opin Neurobiol 8:697-704. 1998
    ..Many of the same molecules participate in the guidance of both vertebrate and fly motor axons. It is less clear, however, whether the same molecular mechanisms establish vertebrate and fly motoneuron identities...
  63. ncbi "Painting" the target: how local molecular cues define synaptic relationships
    A Chiba
    Department of Cell and Structural Biology, University of Illinois, Urbana, USA
    Bioessays 20:941-8. 1998
    ..In this review, we summarize how such studies are beginning to uncover the repertoire of extrinsic cues that influence the synaptic targeting of a single growth cone...
  64. ncbi Syntagms in development and evolution
    F Huang
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Int J Dev Biol 42:487-94. 1998
    ..In this review, we will describe a series of developmental syntagms, and explore the consequences of this discontinuous organization of the developmental program on evolution...
  65. ncbi Control of cell lineage-specific development and transcription by bHLH-PAS proteins
    S T Crews
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7260 USA
    Genes Dev 12:607-20. 1998
  66. ncbi DCC's function takes shape in the nervous system
    P A Kolodziej
    823 Light Hall, Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0295, USA vanderbilt edu
    Curr Opin Genet Dev 7:87-92. 1997
    b>Deleted in colorectal cancer (DCC), a candidate tumor-suppressor gene, has recently been found to encode a netrin receptor required for axon guidance in vitro...
  67. ncbi Netrins find their receptor
    U Drescher
    Nature 384:416-7. 1996
  68. ncbi Neurons and glia: team players in axon guidance
    Carole Chotard
    National Institute for Medical Research, Division of Molecular Neurobiology, The Ridgeway, London NW7 1AA, UK
    Trends Neurosci 27:655-61. 2004
    ..Equally, neurons provide crucial information to glia, supporting their migration and correct positioning...
  69. ncbi Engrailed controls the organization of the ventral nerve cord through frazzled regulation
    Willy Joly
    Institute of Human Genetics, IGH, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Dev Biol 301:542-54. 2007
    ..These results indicate that Engrailed's function during the segregation of the neuroblasts is crucial for regulating different actors that are later involved in axon guidance...
  70. ncbi Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration
    Nara I Muraro
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Neurobiol 66:1338-53. 2006
    ....
  71. pmc Regulation of axon guidance by slit and netrin signaling in the Drosophila ventral nerve cord
    Krishna Moorthi Bhat
    Department of Neuroscience and Cell Biology, School of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Genetics 176:2235-46. 2007
    ..Our results argue that double mutant epistasis is most definitive only if the penetrance of the phenotypes of the mutants involved is complete...
  72. ncbi NETRIN and SLIT guide salivary gland migration
    Tereza Kolesnikov
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Dev Biol 284:102-11. 2005
    ..We propose that analogous to axon guidance, a balance between chemo-attractants and chemo-repellents is required for the proper migratory path of the developing salivary glands...
  73. pmc Slit-roundabout signaling neutralizes netrin-Frazzled-mediated attractant cue to specify the lateral positioning of longitudinal axon pathways
    Krishna Moorthi Bhat
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322
    Genetics 170:149-59. 2005
    ..Thus, the growth cones of longitudinal tracts subjected to two opposing forces are able to block one with the other and specify their correct lateral positioning along the midline...
  74. doi Abelson tyrosine kinase and Calmodulin interact synergistically to transduce midline guidance cues in the Drosophila embryonic CNS
    Anita Hsouna
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Int J Dev Neurosci 26:345-54. 2008
    ....
  75. doi Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila
    Jop Kind
    Gene Expression Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell 133:813-28. 2008
    ..Therefore, MOF is not only involved in the onset of dosage compensation, but also acts as a regulator of gene expression in the Drosophila genome...
  76. pmc Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons
    Yimiao Ou
    Centre for Research in Neuroscience, McGill University, Cedar Ave, Montreal, QC, H3G 1A4, Canada
    Neural Dev 3:16. 2008
    ..To address these issues, we have carried out two comparable gain-of-function screens for genes that influence dendrite morphologies in peripheral dendritic arborisation (da) neurons and central RP2 motor neurons...
  77. ncbi The Drosophila RNA-binding protein ELAV is required for commissural axon midline crossing via control of commissureless mRNA expression in neurons
    Elena Simionato
    Genes, Développement et Neurogenèse, UMR 8080 CNRS Université Paris XI Bât 445, 91405 Orsay Cedex, France
    Dev Biol 301:166-77. 2007
    ..Finally, forced expression of comm in specific commissural neuron subsets rescues the midline crossing defects of these neurons in elav mutant embryos, further indicating that elav acts cell autonomously on comm expression...
  78. ncbi The Drosophila ARF6-GEF Schizo controls commissure formation by regulating Slit
    Susanne Onel
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Development 131:2587-94. 2004
    ..We thus propose that the balance of the two signaling cues Netrin and Slit can be regulated, controlling membrane dynamics...
  79. ncbi FASt remodeling of synapses in Drosophila
    Mary Packard
    Department of Neurobiology, University of Massachusetts Medical School, Aaron Lazare Medical Research Building, 364 Plantation Street, Worcester, MA 01605 2324, USA
    Curr Opin Neurobiol 13:527-34. 2003
    ..These studies offer convincing evidence that synaptic cell adhesion brings about both negative and positive forces that stabilize synapses, while maintaining their ability to change in an activity-dependent manner...
  80. ncbi Axon guidance: Comm hither, Robo
    Jessica Couch
    Department of Biology, 071 Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Curr Biol 12:R741-2. 2002
    ..Recent studies have shed new light on the mechanism by which commissural axons change their sensitivity to guidance cues after crossing the midline...
  81. ncbi Altered levels of Gq activity modulate axonal pathfinding in Drosophila
    Anuradha Ratnaparkhi
    National Center for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 22:4499-508. 2002
    ....
  82. ncbi Axon guidance: the cytoplasmic tail
    Bharatkumar N Patel
    Program in Neuroscience, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Cell Biol 14:221-9. 2002
    ..Recent studies demonstrate a critical role for the cytoplasmic tails of guidance receptors in signalling and also reveal the potential for a great deal of crosstalk between the various receptor-signalling pathways...
  83. ncbi Frazzled precision guides axons
    R J Giger
    Nature 406:841, 843. 2000
  84. doi Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors
    Bettina Spitzweck
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 140:409-20. 2010
    ..These data demonstrate how diversification of expression and structure within a single family of guidance receptors can shape complex patterns of neuronal wiring...
  85. doi Induction of cellular growth by the axon guidance regulators netrin A and semaphorin-1a
    Ellen Flannery
    Department of Biological Sciences, Walther Cancer Institute, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Dev Neurobiol 70:473-84. 2010
    ..The abilities of NetA and Sema1a to regulate cellular growth are likely critical to their functions in both nervous system development and oncogenesis...
  86. ncbi Neuronal guidance. A genetic perspective
    G Tear
    Department of Biochemistry, Imperial College, London, UK
    Trends Genet 15:113-8. 1999
    ..Here I highlight the part genetic screens and analyses have played in revealing some of the key players in neuronal guidance...

Research Grants7

  1. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
    ..abstract_text> ..
  2. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
    ..These studies will help understand pathways that govern the lineage elaboration in the Drosophila CNS as well as in other eukaryotic organisms including humans. ..
  3. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
    ..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
  4. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
    ..This work will provide insight into the role of these proteins in neurodegenerative diseases and development. ..
  5. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
    ..Our proposed studies will provide insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  6. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008
    ..This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback. [unreadable] [unreadable] [unreadable]..
  7. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
    ..abstract_text> ..