Fas2

Summary

Gene Symbol: Fas2
Description: Fasciclin 2
Alias: 1D4, Ab 1D4, CG3665, CT12301, Dmel\CG3665, EG:EG0007.3, FAS 11, FAS II, FAS2, FASII, Fas, Fas 2, Fas II, Fas-II, FasII, FascII, Fasii, MAB1D4, anon-EST:Liang-1.60, clone 1.60, fas II, fas-II, fas2, fasII, fasciclin II, l(1)G0032, l(1)G0048, l(1)G0081, l(1)G0293, l(1)G0336, mAB1D4, mAb 1D4, mAb1D4, CG3665 gene product from transcript CG3665-RF, CG3665-PA, CG3665-PB, CG3665-PC, CG3665-PD, CG3665-PF, CG3665-PG, CG3665-PH, FASCICLIN II, Fas, Fas2-PA, Fas2-PB, Fas2-PC, Fas2-PD, Fas2-PF, Fas2-PG, Fas2-PH, FasciclinII, fasII, fascicilin II, fasciclin, fasciclin 2, fasciclin-2, fasciclin-II, fasciclin2, fasciculin II, fascilin II, fasiclin II
Species: fruit fly

Top Publications

  1. pmc A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 175:491-503. 2006
  2. ncbi Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner
    Giuseppa Pennetta
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 35:291-306. 2002
  3. ncbi Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila
    K Zito
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 22:719-29. 1999
  4. pmc Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells
    Jason Q Boone
    Institute of Neuroscience and Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Dev Neurobiol 68:1185-95. 2008
  5. ncbi Presynaptic spectrin is essential for synapse stabilization
    Jan Pielage
    Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Curr Biol 15:918-28. 2005
  6. pmc Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons
    Mari Palgi
    Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 106:2429-34. 2009
  7. doi APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS
    Marion Silies
    Institut fur Neurobiologie, Universitat Munster, Munster, Germany
    Nat Neurosci 13:1357-64. 2010
  8. ncbi Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs
    M L Winberg
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 93:581-91. 1998
  9. ncbi Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule
    G Grenningloh
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 67:45-57. 1991
  10. ncbi Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance
    D M Lin
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Neuron 13:507-23. 1994

Research Grants

  1. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2003
  2. PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTION
    Richard Carthew; Fiscal Year: 2005
  3. Mitochondrial Dysfunction and Progressive Encephalomyopathies
    MICHAEL JOHN PALLADINO; Fiscal Year: 2010
  4. Understanding the Mechanisms of Neuropathogenesis
    MICHAEL JOHN PALLADINO; Fiscal Year: 2010
  5. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
  6. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2008
  7. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008
  8. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
  9. PITT-SPURG Summer Program for Undergrad Research Growth
    Michael Palladino; Fiscal Year: 2008
  10. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007

Detail Information

Publications188 found, 100 shown here

  1. pmc A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 175:491-503. 2006
    ..We propose a model in which a postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged...
  2. ncbi Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner
    Giuseppa Pennetta
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 35:291-306. 2002
    ..We propose that a DVAP-33A-mediated interaction between microtubules and presynaptic membrane plays a pivotal role during bouton budding...
  3. ncbi Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila
    K Zito
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 22:719-29. 1999
    ..Some new boutons exhibit a lower level of Fasciclin II, suggesting that the levels of this synaptic cell adhesion molecule vary locally during synaptic growth.
  4. pmc Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells
    Jason Q Boone
    Institute of Neuroscience and Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Dev Neurobiol 68:1185-95. 2008
    ..Type II lineages allow more neurons to be produced faster than Type I lineages, which may be advantageous in a rapidly developing organism like Drosophila...
  5. ncbi Presynaptic spectrin is essential for synapse stabilization
    Jan Pielage
    Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Curr Biol 15:918-28. 2005
    ..Precise neural circuitry is established and maintained through a regulated balance of synapse stabilization and disassembly. Currently, little is known about the molecular mechanisms that specify synapse stability versus disassembly...
  6. pmc Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons
    Mari Palgi
    Institute of Biotechnology, University of Helsinki, 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 106:2429-34. 2009
    ..The rescue experiments confirm DmMANF as a functional ortholog of the human MANF gene thus opening the window for comparative studies of this protein family with potential for the treatment of Parkinson's disease...
  7. doi APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS
    Marion Silies
    Institut fur Neurobiologie, Universitat Munster, Munster, Germany
    Nat Neurosci 13:1357-64. 2010
    ..We found that Fzr/Cdh1 function is mediated by the immunoglobulin superfamily cell adhesion molecule Fasciclin2 (Fas2). In motor neurons Fzr/Cdh1 is crucial for the establishment of a graded axonal distribution of Fas2...
  8. ncbi Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial functions of netrins, semaphorins, and IgCAMs
    M L Winberg
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 93:581-91. 1998
    ..targets were dissected using Drosophila genetics to add or subtract Netrin A, Netrin B, Semaphorin II, and Fasciclin II alone or in combination...
  9. ncbi Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule
    G Grenningloh
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 67:45-57. 1991
    ..In both grasshopper and Drosophila, fasciclin II is expressed on the MP1 fascicle and a subset of other axon pathways...
  10. ncbi Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance
    D M Lin
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Neuron 13:507-23. 1994
    We used the enhancer detection/GAL4 system in Drosophila to direct increased levels of Fasciclin II (Fas II) expression on motoneuron growth cones and axons and to direct ectopic Fas II expression on other cells they encounter...
  11. ncbi Plexin A is a neuronal semaphorin receptor that controls axon guidance
    M L Winberg
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 95:903-16. 1998
    ..Plexins, which themselves contain complete Semaphorin domains, may be both the ancestors of classical Semaphorins and binding partners for Semaphorins...
  12. ncbi Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
    D Schmucker
    Howard Hughes Medical Institute, Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, California 90095, USA
    Cell 101:671-84. 2000
    ..Alternative splicing can potentially generate more than 38,000 Dscam isoforms. This molecular diversity may contribute to the specificity of neuronal connectivity...
  13. ncbi Respective roles of the DRL receptor and its ligand WNT5 in Drosophila mushroom body development
    Nicola Grillenzoni
    Institut de Genetique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex, France
    Development 134:3089-97. 2007
    ..We therefore propose that the neuronal requirement for both proteins defines an interacting network acting during MB development...
  14. doi Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors
    Bettina Spitzweck
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 140:409-20. 2010
    ..These data demonstrate how diversification of expression and structure within a single family of guidance receptors can shape complex patterns of neuronal wiring...
  15. ncbi even-skipped determines the dorsal growth of motor axons in Drosophila
    M Landgraf
    Department of Zoology, University of Cambridge, United Kingdom
    Neuron 22:43-52. 1999
    ..Thus, even-skipped complements the function of islet, and together these two genes constitute a bimodal switch regulating axonal growth and directing motor axons to ventral or to dorsal regions of the muscle field...
  16. ncbi Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila
    Ke Zhang
    Institute of Neuroscience, Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences CAS, 320 Yueyang Road, Shanghai 200031, China
    Science 316:1901-4. 2007
    ..Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila...
  17. pmc Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily
    Mili Jeon
    Broad Center, Division of Biology, California Institute of Technology Pasadena, California 91125, USA
    Neural Dev 3:3. 2008
    ..Highly penetrant central nervous system (CNS) and motor axon guidance alterations are usually observed only when specific combinations of two or more RPTPs are removed. Here, we examine the sixth RPTP, Ptp4E, which is broadly expressed...
  18. pmc Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton
    Catherine M Massaro
    Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 187:101-17. 2009
    ....
  19. pmc Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release
    Tanja Wucherpfennig
    Max Planck Institut für molekulare Zellbiologie und Genetik, Dresden, Germany
    J Cell Biol 161:609-24. 2003
    ..Conversely, Rab5 overexpression increases the release efficacy. Therefore, the Rab5-dependent trafficking pathway plays an important role for synaptic performance...
  20. ncbi Pattern formation in the visual centers of the Drosophila brain: wingless acts via decapentaplegic to specify the dorsoventral axis
    K Kaphingst
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Cell 78:437-48. 1994
    ..These observations implicate a cascade of diffusible signaling molecules in patterning the visual centers of the Drosophila brain...
  21. ncbi Neuropil pattern formation and regulation of cell adhesion molecules in Drosophila optic lobe development depend on synaptobrevin
    P R Hiesinger
    University of Freiburg, Institute of Biology III, D 79104 Freiburg, Germany
    J Neurosci 19:7548-56. 1999
    ..In photoreceptors, targeted toxin expression results in increased Fasciclin II and chaoptin but not IrreC-rst immunoreactivity. Axonal pathfinding and programmed cell death are not affected...
  22. ncbi Highwire regulates synaptic growth in Drosophila
    H I Wan
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 26:313-29. 2000
    ..Within presynaptic terminals, HIW is localized to the periactive zone surrounding active zones; Fasciclin II (Fas II), which also controls synaptic growth, is found at the same location.
  23. ncbi CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein
    Annette Schenck
    Department of Molecular Pathology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Boite Postale 10142, 67404 Illkirch, Cedex, France
    Neuron 38:887-98. 2003
    ..CYFIP interacts biochemically and genetically with dFMR1 and dRac1. Finally, CYFIP acts as a dRac1 effector that antagonizes FMR1 function, providing a bridge between signal-dependent cytoskeleton remodeling and translation...
  24. ncbi WAVE/SCAR, a multifunctional complex coordinating different aspects of neuronal connectivity
    Annette Schenck
    Department of Developmental Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, B P 10142, 67404 Illkirch Cedex, C U de Strasbourg, France
    Dev Biol 274:260-70. 2004
    ..Thus, our results identify the Drosophila WAVE/SCAR complex as a multifunctional unit orchestrating different pathways and aspects of neuronal connectivity...
  25. pmc Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons
    Suewei Lin
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 4:e8392. 2009
    ..In sum, unf governs axonal morphogenesis of multiple MB neuron types, possibly through regulating neuronal subtype identity...
  26. doi The Wnt5/planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron
    Kazumichi Shimizu
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    J Neurosci 31:4944-54. 2011
    ..Wnt5 was broadly expressed in the developing brain. We propose that Wnt5 and the PCP pathway concertedly regulate axonal development of the MB...
  27. ncbi Developmental dynamics of peripheral glia in Drosophila melanogaster
    K J Sepp
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Glia 30:122-33. 2000
    ..Peripheral glia seem to have dynamic and diverse roles and their similarities to vertebrate glia suggest that Drosophila may serve as a powerful tool for analysis of glial roles in PNS development in the future...
  28. ncbi The retinoic-like juvenile hormone controls the looping of left-right asymmetric organs in Drosophila
    Geza Adam
    Institute of Signaling, Developmental Biology and Cancer, Centre de Biochimie UMR 6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France
    Development 130:2397-406. 2003
    ..spin is a novel, rotation-specific allele of the fasciclin2 (Fas2) gene, which encodes a cell-adhesion protein involved in several aspects of neurogenesis...
  29. ncbi The gene tinman is required for specification of the heart and visceral muscles in Drosophila
    R Bodmer
    Department of Biology, University of Michigan, Ann Arbor 48109 1048
    Development 118:719-29. 1993
    ....
  30. ncbi Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
    K J Mitchell
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley California 94720, USA
    Neuron 17:203-15. 1996
    ..Expression of either Netrin gene in all muscles also results in aberrant motor projections. Thus, Drosophila Netrins are required for the guidance of commissural axons at the midline, and of motor axons to their target muscles...
  31. ncbi Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 92:205-15. 1998
    ..Transgenic rescue experiments reveal that Robo can function in a cell-autonomous fashion. Robo appears to function as the gatekeeper controlling midline crossing...
  32. pmc Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation
    Y H Koh
    Department of Biology, University of Massachusetts, Amherst 01003, USA
    Cell 98:353-63. 1999
    ..We propose that CaMKII-dependent DLG phosphorylation regulates the association of DLG with the synaptic complex during development and plasticity, thus providing a link between synaptic activity and structure...
  33. ncbi Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix
    D Parnas
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 32:415-24. 2001
    ..dpix mutations lead to decreased synaptic levels of the PDZ protein Dlg, the cell adhesion molecule Fas II, and the glutamate receptor subunit GluRIIA, and to a complete reduction of the serine/threonine kinase Pak and ..
  34. ncbi MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion
    Jonathan R Terman
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 109:887-900. 2002
    ..These results suggest a novel role for oxidoreductases in repulsive neuronal guidance...
  35. ncbi Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
    Robert J Kittel
    European Neuroscience Institute Göttingen, Grisebachstrasse 5, 37077 Gottingen, Germany
    Science 312:1051-4. 2006
    ..BRP-like proteins seem to establish proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity...
  36. pmc The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance
    Yi Lan Weng
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 31:4421-33. 2011
    ..Together, these studies identify caskin as a neuronal adaptor protein required for axon growth and guidance...
  37. pmc Regulation of Fasciclin II and synaptic terminal development by the splicing factor beag
    Erin S Beck
    Center for Motor Neuron Biology and Disease, Department of Pathology and Cell Biology and Department of Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
    J Neurosci 32:7058-73. 2012
    ..and mutants of an interacting gene dsmu1 have changes in the synaptic levels of specific splice isoforms of Fasciclin II (FasII), the Drosophila ortholog of neural cell adhesion molecule...
  38. ncbi Regulated spacing of synapses and presynaptic active zones at larval neuromuscular junctions in different genotypes of the flies Drosophila and Sarcophaga
    I A Meinertzhagen
    Neuroscience Institute, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    J Comp Neurol 393:482-92. 1998
    ..Sarcophaga and Drosophila and Drosophila mutants dunce(m14) and fasII(e76), a hypomorphic allele of the fasciclin II gene; and axon 2--drosophila wild-type, dunce(m14), and fasII(e76)...
  39. pmc The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation
    Karen T Chang
    Neurogenetics Branch MSC1250, National Institute of Neurological Disorders and Stroke, 10 3B12, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15794-9. 2003
    ....
  40. ncbi Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth
    C M Schuster
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 17:641-54. 1996
    ..We further show that, after synapse formation, the homophilic cell adhesion molecule Fasciclin II (Fas II) is localized both pre- and postsynaptically where it controls synapse stabilization...
  41. ncbi Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity
    C M Schuster
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 17:655-67. 1996
    ..growth is accompanied by an approximately 50% decrease in synaptic levels of the cell adhesion molecule Fasciclin II (Fas II)...
  42. ncbi The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity
    S Zaffran
    Laboratoire de Genetique et Physiologie du Developpement, UMR 9943 CNRS Université, IBDM CNRS INSERM, Universite de la Mediterranee, Campus de Luminy Case, Marseille, France
    Development 124:2087-98. 1997
    ..The properties of the how gene described herein suggest that this gene participates in the control of expression of as yet unidentified target mRNAs coding for proteins essential to cardiac and muscular activity...
  43. ncbi The transmembrane Semaphorin Sema I is required in Drosophila for embryonic motor and CNS axon guidance
    H H Yu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 20:207-20. 1998
    ..These studies further suggest that like secreted semaphorins, transmembrane semaphorins can function as repulsive guidance cues for specific axon guidance events during neurodevelopment...
  44. pmc The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding
    Bader Al-Anzi
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Neural Dev 4:31. 2009
    ..However, a large number of commissural axons successfully cross the midline even in the complete absence of netrin signaling, indicating the presence of a yet unidentified midline attractant...
  45. ncbi Glia maintain follower neuron survival during Drosophila CNS development
    G E Booth
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, Cambridge, UK
    Development 127:237-44. 2000
    ..This differential requirement of neurons for glia is instructive in patterning and links control of cell number with axon guidance during CNS development...
  46. ncbi Molecular genetics of neuronal recognition in Drosophila: evolution and function of immunoglobulin superfamily cell adhesion molecules
    G Grenningloh
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cold Spring Harb Symp Quant Biol 55:327-40. 1990
  47. ncbi Argos and Spitz group genes function to regulate midline glial cell number in Drosophila embryos
    C Stemerdink
    Department of Biology, McMaster University, Hamilton ON, Canada
    Development 124:3787-96. 1997
    ..In this manner, midline glia not forming signaling junctions remain sensitive to juxtacrine Argos signaling, while an autocrine Argos signal is excluded by the adhesive junction...
  48. ncbi Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg
    K Zito
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 19:1007-16. 1997
    Previous studies have shown that both the Fasciclin II (Fas II) cell adhesion molecule and the Shaker potassium channel are localized at the Drosophila neuromuscular junction, where they function in the growth and plasticity of the ..
  49. ncbi Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 20:25-33. 1998
    ..The levels of Comm and Robo appear to be tightly regulated to assure that only certain growth cones cross the midline and that those growth cones that do cross never do so again...
  50. ncbi Neurotactin functions in concert with other identified CAMs in growth cone guidance in Drosophila
    S Speicher
    Centro de Biología Molecular Severo Ochoa C S I C U A M, Universidad Autonoma, Madrid, Spain
    Neuron 20:221-33. 1998
    ..This result provides evidence for functional cooperativity in vivo between the adhesion and signaling pathways controlled by neurotactin and the other three genes...
  51. ncbi Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
    G J Bashaw
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 97:917-26. 1999
    ..Robo-Fra (Robo's ectodomain and Fra's cytoplasmic domain) is an attractive Slit receptor; neurons and muscle precursors expressing Robo-Fra are attracted to the Slit-expressing midline...
  52. pmc The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization
    T Hummel
    Institut fur Neurobiologie, Universitat Munster, D 48149 Munster, Germany
    Genes Dev 14:863-73. 2000
    ..In addition, the kette mutant phenotype can be partially rescued by expression of an activated DRAC1 transgene. Our data suggest an important role of the HEM-2 protein in cytoskeletal organization during axonal pathfinding...
  53. ncbi Highwire, rpm-1, and futsch: balancing synaptic growth and stability
    Q Chang
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 26:287-90. 2000
  54. ncbi Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position
    J H Simpson
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, 519 LSA, University of California, Berkeley CA 94720, USA
    Cell 103:1019-32. 2000
    ..Precise topography of longitudinal pathways appears to be controlled by a combination of long-range guidance (the Robo code determining region) and short-range guidance (discrete local cues determining specific location within a region)...
  55. ncbi Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 103:1033-45. 2000
    ..Local cues further refine the lateral position. Together, these long- and short-range guidance cues allow growth cones to select with precision a specific longitudinal pathway...
  56. ncbi Altered electrical properties in Drosophila neurons developing without synaptic transmission
    R A Baines
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ United Kingdom
    J Neurosci 21:1523-31. 2001
    ....
  57. ncbi The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance
    M L Winberg
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 519 LSA, University of California, Berkeley, CA 94720, USA
    Neuron 32:53-62. 2001
    ..The otk gene displays strong genetic interactions with Sema1a and PlexA, suggesting that OTK and Plexin A function downstream of Sema 1a...
  58. ncbi Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons
    Jian Wang
    Department of Cell and Structural Biology, University of Illinois, Urbana, IL 61801, USA
    Neuron 33:559-71. 2002
    ..Taken together, we conclude that Dscam controls axon branching and guidance such that a neuron can innervate multiple targets with minimal branching...
  59. pmc Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein
    Dennis Mathew
    Department of Biology and Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA
    Curr Biol 12:531-9. 2002
    ..Likewise, the biochemical nature of this interaction remains elusive, raising questions regarding the mechanisms by which the actions of both proteins are coordinated...
  60. ncbi Dephrin, a transmembrane ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophila embryonic CNS
    Torsten Bossing
    Wellcome Trust Cancer Research UK Institute and Department of Genetics, Cambridge University, Tennis Court Road, Cambridge, CB2 1QR, UK
    Development 129:4205-18. 2002
    ..We propose that the longitudinal tracts in the Drosophila CNS are moulded by a repulsive outer border of Dephrin expression...
  61. ncbi A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding
    Zachary Wills
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 36:611-22. 2002
    ..These studies identify Capulet as part of an emerging pathway linking guidance signals to regulation of cytoskeletal dynamics and suggest that the Abl pathway mediates signals downstream of multiple Roundabout receptors...
  62. ncbi Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neurites
    Matthias Landgraf
    Department of Zoology, Downing Street, CB2 3EJ, Cambridge, UK
    Dev Biol 260:207-25. 2003
    ..for neurite mapping, using a set of evenly distributed landmarks labelled by commercially available anti-Fasciclin2 antibodies which remain comparatively constant between specimens and over developmental time...
  63. ncbi Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons
    Michael E Rothenberg
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuron 39:779-91. 2003
    ..Taken together, these results reveal novel activities for pod-1 and show that proper levels of Dpod1, an actin/MT crosslinker, must be maintained in the growth cone for correct axon guidance...
  64. ncbi Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants
    Carlos I Michel
    Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721 0077, USA
    J Neurosci 24:5798-809. 2004
    ..Mutations of dfmr1 also interact with one or more third-chromosome loci to promote alpha/beta-lobe maturation. These data further support the use of the Drosophila model system for study of hereditary cognitive disorders of humans...
  65. ncbi Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint
    James Ashley
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 25:5943-55. 2005
    ..Here, we used the Drosophila larval neuromuscular junction to investigate the pathways activated by Fasciclin II (FasII), a transmembrane CAM of the Ig superfamily, during synapse remodeling...
  66. ncbi A role for Fas II in the stabilization of motor neuron branches during pruning in Drosophila
    Sarita Hebbar
    Department of Zoology, 250 Pearson Hall, Miami University, Oxford, OH 45056, USA
    Dev Biol 285:185-99. 2005
    ..In this study, we show that the cell adhesion molecule, Fasciclin II (Fas II), is important for generating the stereotypic pattern...
  67. ncbi Glutamate receptor dynamics organizing synapse formation in vivo
    Tobias M Rasse
    European Neuroscience Institute Göttingen, Max Planck Society, Waldweg 33, D 37073 Gottingen, Germany
    Nat Neurosci 8:898-905. 2005
    ....
  68. ncbi Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements
    Chunlai Wu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9557-66. 2005
    ....
  69. ncbi Semaphorin-1a functions as a guidance receptor in the Drosophila visual system
    Patrick Cafferty
    McGill Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada
    J Neurosci 26:3999-4003. 2006
    ..The function of Sema1a in R-cell axon guidance absolutely requires its cytoplasmic domain. We propose that Sema1a functions as a receptor in regulating R-cell axon guidance in the Drosophila visual system...
  70. ncbi Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis
    Takeshi Awasaki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Neuron 50:855-67. 2006
    ..These findings suggest that glial cells engulf degenerating axons through drpr and ced-6. We propose that apoptotic cells and degenerating axons of living neurons are removed by a similar molecular mechanism...
  71. ncbi Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity
    Sijun Zhu
    Department of Cell and Developmental Biology, University of Illinois, Urbana, 61801, USA
    Cell 127:409-22. 2006
    ..Taken together, we suggest that a temporal gradient of Chinmo (Chinmo(high) --> Chinmo(low)) helps specify distinct birth order-dependent cell fates in an extended neuronal lineage...
  72. ncbi Neurotransmitter-induced changes in the intracellular calcium concentration suggest a differential central modulation of CCAP neuron subsets in Drosophila
    Matthias Vömel
    Emmy Noether Neuropeptide Group, Animal Physiology, Department of Biology, Philipps University Marburg, Karl von Frisch Strasse, Marburg D 35032, Germany
    Dev Neurobiol 67:792-808. 2007
    ..Our results suggest that N(CCAP) express functional receptors for ACh, glutamate, and GABA, and indicate that these transmitters are involved in a context-dependent regulation of functionally distinct N(CCAP) subsets...
  73. pmc Differentiation of the Drosophila serotonergic lineage depends on the regulation of Zfh-1 by Notch and Eagle
    Hyung Kook Lee
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell Neurosci 36:47-58. 2007
    ..Our observations on the regulation of Zfh-1 provide a new approach for examining the function of Zfh-1 in motor neurons and larval locomotion...
  74. pmc Neuroarchitecture of aminergic systems in the larval ventral ganglion of Drosophila melanogaster
    Matthias Vömel
    Emmy Noether Neuropeptide Group, Animal Physiology, Department of Biology, Philipps University Marburg, Marburg, Germany
    PLoS ONE 3:e1848. 2008
    ..neurons in the thoracic and abdominal neuromeres of the Drosophila larval ventral ganglion relying on Fasciclin2-immunoreactive tracts as three-dimensional landmarks...
  75. pmc Requirement for a core 1 galactosyltransferase in the Drosophila nervous system
    Yuh Ru Lin
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Dev Dyn 237:3703-14. 2008
    ..Lectin staining and blotting experiments confirmed that C1GalTA contributes to the synthesis of Gal-beta1,3-GalNAc in vivo. Our results identify a role for mucin-type O-glycosylation during neural development in Drosophila...
  76. doi Distinctive neuronal networks and biochemical pathways for appetitive and aversive memory in Drosophila larvae
    Ken Honjo
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Neurosci 29:852-62. 2009
    ..These results as a whole suggest that the genetically programmed memory circuitries might provide predisposition in the efficacy of inducing longer-lived memory components in associative learning...
  77. pmc Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis
    Hsiu Hsiang Lee
    Howard Hughes Medical Institute, Department of Physiology, Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:6363-8. 2009
    ..Our study thus implicates Ik2 and Kat-60L1 in dendrite severing that involves local microtubule disassembly...
  78. pmc Fasciclin II controls proneural gene expression in Drosophila
    L Garcia-Alonso
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Proc Natl Acad Sci U S A 92:10501-5. 1995
    b>Fasciclin II (Fas II), an NCAM-like cell adhesion molecule in Drosophila, is expressed on a subset of embryonic axons and controls selective axon fasiculation. Fas II is also expressed in imaginal discs...
  79. ncbi A Drosophila receptor tyrosine phosphatase expressed in the embryonic CNS and larval optic lobes is a member of the set of proteins bearing the "HRP" carbohydrate epitope
    C J Desai
    Division of Biology, California Institute of Technology, Pasadena 91125
    J Neurosci 14:7272-83. 1994
    ..Western blotting data suggest that fasciclin II, neuroglian, DPTP10D, and DPTP99A are also HRP proteins...
  80. ncbi Wiring by fly: the neuromuscular system of the Drosophila embryo
    M Bate
    Department of Zoology, University of Cambridge, England
    Neuron 15:513-25. 1995
  81. ncbi huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding
    Q Chu-LaGraff
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Neuron 15:1041-51. 1995
    ..Thus, huckebein regulates aspects of GMC and neuronal identity required for proper motoneuron axon pathfinding in the NB 4-2 lineage...
  82. ncbi Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member
    C A Callahan
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, California 92186, USA
    Nature 376:171-4. 1995
    ..In drl mutant embryos these neurons fail to make the correct pathway choices. Our results provide evidence for receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition...
  83. ncbi Development of Drosophila wing sensory neurons in mutants with missing or modified cell surface molecules
    K E Whitlock
    Department of Zoology, University of Washington, Seattle 98195
    Development 117:1251-60. 1993
    ..The animals used were mutant for the fasciclinI (fasI), fasciclinII (fasII), fasciclinIII (fasIII) and neurally altered carbohydrate (nac) genes...
  84. ncbi Genes that control neuromuscular specificity in Drosophila
    D V Vactor
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 73:1137-53. 1993
    ....
  85. ncbi Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology
    B A Stewart
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurosci 16:3877-86. 1996
    ..Animals that have an extreme hypomorphic allele of the gene for the cell adhesion molecule Fasciclin II possess fewer synapse-bearing nerve terminal varicosities; nevertheless, synaptic strength is maintained at a ..
  86. ncbi Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones
    A Prokop
    Department of Zoology, University of Cambridge, United Kingdom
    Neuron 17:617-26. 1996
    ..Thus, the process of synapse formation can be genetically separated from the process of target recognition, revealing that localization of presynaptic active zones requires mef2-dependent muscle differentiation...
  87. ncbi Mutations in the Drosophila neuroglian cell adhesion molecule affect motor neuron pathfinding and peripheral nervous system patterning
    S G Hall
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA
    J Neurobiol 32:325-40. 1997
    ....
  88. ncbi Role of Drosophila alpha-adaptin in presynaptic vesicle recycling
    M Gonzalez-Gaitan
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Gottingen, Germany
    Cell 88:767-76. 1997
    ..Our results suggest an alpha-adaptin-dependent control of the vesicle cycle that maintains the balance between the amount of vesicle- and surface-associated membranes...
  89. ncbi Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS
    Y Iwai
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Sakyo ku, Japan
    Neuron 19:77-89. 1997
    ..These results suggest that processes of axon patterning critically depend on DN-cadherin-mediated axon-axon interactions...
  90. pmc Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure
    U Thomas
    Department of Neurochemistry and Molecular Biology, Federal Institute for Neurobiology, Magdeburg, Germany
    Neuron 19:787-99. 1997
    The cell adhesion molecule Fasciclin II (FASII) is involved in synapse development and plasticity...
  91. ncbi Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin
    D L Deitcher
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosci 18:2028-39. 1998
    ..Thus, at least a portion of the spontaneous "minis" that are seen at the synapse can be generated by a protein complex that is distinct from that required for an evoked synaptic response...
  92. pmc Structural requirements for outside-in and inside-out signaling by Drosophila neuroglian, a member of the L1 family of cell adhesion molecules
    M Hortsch
    University of Michigan, Department of Anatomy and Cell Biology, Ann Arbor, Michigan 48109 0616, USA
    J Cell Biol 142:251-61. 1998
    ..the extracellular domain of neuroglian was replaced with the corresponding domain from the adhesion molecule fasciclin II, also selectively recruited ankyrin to cell contacts...
  93. ncbi The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
    Z Wills
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 22:301-12. 1999
    ..These data suggest that Dlar, Abl, and Ena define a phosphorylation state-dependent switch that controls growth cone behavior by transmitting signals at the cell surface to the actin cytoskeleton...
  94. ncbi Slit is the midline repellent for the robo receptor in Drosophila
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 96:785-94. 1999
    ..Slit appears to function as a short-range repellent controlling axon crossing of the midline and as a long-range chemorepellent controlling mesoderm migration away from the midline...
  95. pmc Genetic control of development of the mushroom bodies, the associative learning centers in the Drosophila brain, by the eyeless, twin of eyeless, and Dachshund genes
    M Kurusu
    Institute of Biological Sciences, University of Tsukuba, Tsukuba 305 8572, Japan
    Proc Natl Acad Sci U S A 97:2140-4. 2000
    ..These data argue for a distinct combinatorial code of regulatory genes for MBs as compared with eye development and suggest conserved roles of Pax6 homologs in the genetic programs of the olfactory learning centers of complex brains...
  96. ncbi Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
    G J Bashaw
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 101:703-15. 2000
    ..A mutant form of Robo that interferes with Ena binding is partially impaired in Robo function, while a mutation in a conserved cytoplasmic tyrosine that can be phosphorylated by Abl generates a hyperactive Robo receptor...
  97. ncbi Early development of the Drosophila mushroom body: the roles of eyeless and dachshund
    A Noveen
    Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA 90095 1606, USA
    Development 127:3475-88. 2000
    ..These results indicate that ey and dachshund may have a role in axon pathway selection during embryogenesis...
  98. ncbi Synaptic development is controlled in the periactive zones of Drosophila synapses
    M Sone
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Development 127:4157-68. 2000
    A cell-adhesion molecule fasciclin 2 (FAS2), which is required for synaptic growth and still life (SIF), an activator of RAC, were found to localize in the surrounding region of the active zone, defining the periactive zone in Drosophila ..
  99. ncbi sidestep encodes a target-derived attractant essential for motor axon guidance in Drosophila
    H Sink
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, 519 LSA, University of California, Berkeley, CA 94720, USA
    Cell 105:57-67. 2001
    ..Ectopic expression of Side results in extensive and prolonged motor axon contact with inappropriate tissues expressing Side...
  100. ncbi A novel member of the Ig superfamily, turtle, is a CNS-specific protein required for coordinated motor control
    K D Bodily
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840
    J Neurosci 21:3113-25. 2001
    ..These phenotypes demonstrate that tutl plays an essential role in establishing a nervous system capable of executing coordinated motor output in complex behaviors...
  101. ncbi The function of leak and kuzbanian during growth cone and cell migration
    K Schimmelpfeng
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, 48149, Munster, Germany
    Mech Dev 106:25-36. 2001
    ..Our analyses support a model in which Kuzbanian mediates the proteolytic activation of the Slit/Roundabout receptor complex...

Research Grants17

  1. Regulated Gene Expression and Drosophila Behavior
    Ronald Davis; Fiscal Year: 2003
    ..The techniques proposed here offer a general method for turning on gene activity both spatially and temporally in Drosophila. ..
  2. PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTION
    Richard Carthew; Fiscal Year: 2005
    ..abstract_text> ..
  3. Mitochondrial Dysfunction and Progressive Encephalomyopathies
    MICHAEL JOHN PALLADINO; Fiscal Year: 2010
    ..Our model system captures many relevant features of these diseases in an amenable genetic system and this proposal aims to study pathogenesis of these diseases. ..
  4. Understanding the Mechanisms of Neuropathogenesis
    MICHAEL JOHN PALLADINO; Fiscal Year: 2010
    ..Together these specific experiments will elucidate the mechanisms of neuropathogenesis in ATPalpha mutants and lead to a better understanding of age-related neurodegeneration and senescence. ..
  5. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
    ..abstract_text> ..
  6. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2008
    ..As a result, an understanding of the "logic" of how information is processed in relatively simple nervous systems can greatly inform future investigations of human cognition. ..
  7. University of Oregon Animal Resource Improvements
    Judith Eisen; Fiscal Year: 2008
    ..This will significantly increase our ability to ensure the health of our many genetically-distinct, and therefore irreplaceable lines of stickleback. [unreadable] [unreadable] [unreadable]..
  8. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
    ..Our proposed studies will provide insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  9. PITT-SPURG Summer Program for Undergrad Research Growth
    Michael Palladino; Fiscal Year: 2008
    ..This tracking will provide an assessment of the ability of the program to achieve its goals. [unreadable] [unreadable]..
  10. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
    ..This work will provide insight into the role of these proteins in neurodegenerative diseases and development. ..
  11. Pancreas-specific primary regulatory targets of Nkx2.2
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2004
    ..2 target genes. This knowledge may be highly instructive in defining those regulatory networks required for beta islet specification. ..
  12. Molecular Analysis of Brain Development
    Patrick Callaerts; Fiscal Year: 2004
    ..In addition, fundamental insights into neuronal gene regulatory networks will be important to understanding the many brain-related birth defects in children. ..
  13. Palmitoyl Protein Thioesterases in Neural Development
    Quynh Chu LaGraff; Fiscal Year: 2003
    ..Such information may provide insight into the mechanisms of pathogenesis by identifying potential elements that are compromised in Batten Diseases. ..
  14. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
    ..These studies will help understand pathways that govern the lineage elaboration in the Drosophila CNS as well as in other eukaryotic organisms including humans. ..
  15. L1-MEDIATED RECRUITMENT OF THE MEMBRANE SKELETON
    Michael Hortsch; Fiscal Year: 2002
    ..Finally, he will use this assay system to test whether mutant L1-CAM molecules from human patients will function in his assay. ..
  16. HOMEODOMAIN PROTEIN AND CELL TYPE SPECIFICITY
    MELODY SIEGLER; Fiscal Year: 2001
    ..We wish to determine whether cell types are altered, and whether there are other effects on formation of neuronal circuits. ..
  17. HOW DOES VND INTEGRATE POSITIONAL INFORMATION?
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2003
    ..These studies address the structure and function of vnd, a critical regulator of early neuronal development, and may serve as a prototype for vertebrate vnd-like genes. ..