Eno

Summary

Gene Symbol: Eno
Description: Enolase
Alias: BEST:LD15491, CG17654, CT32526, Dmel\CG17654, ENOA, Eno2, T18, anon-WO0153538.76, eno, CG17654 gene product from transcript CG17654-RE, CG17654-PA, CG17654-PB, CG17654-PC, CG17654-PD, CG17654-PE, CG17654-PF, Eno-PA, Eno-PB, Eno-PC, Eno-PD, Eno-PE, Eno-PF, enolase, phosphopyruvate hydratase
Species: fruit fly

Top Publications

  1. doi Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase
    Gabriela Prado Paludo
    Laboratório de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Comput Biol Chem 58:1-8. 2015
  2. pmc Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements
    Ming Gao
    Department of Biological Sciences, Murray State University, Murray, KY, USA
    EMBO Rep 16:379-86. 2015
  3. pmc Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability
    Claire de la Cova
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University Medical Center, 701 West 168th Street, New York, NY 10032, USA
    Cell Metab 19:470-83. 2014
  4. pmc Integrating protein-protein interaction networks with phenotypes reveals signs of interactions
    Arunachalam Vinayagam
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 11:94-9. 2014
  5. pmc Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction
    Samuel E Schriner
    Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e63886. 2013
  6. pmc Evidence for transgenerational metabolic programming in Drosophila
    Jessica L Buescher
    Department of Pediatrics, and
    Dis Model Mech 6:1123-32. 2013
  7. pmc The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis
    Simon Collier
    Department of Biological Sciences, Marshall University, Huntington, West Virginia 25755, USA
    Genetics 169:2035-45. 2005
  8. pmc The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic
    Helen A Lindsay
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QR, UK
    Genetics 180:873-84. 2008
  9. ncbi Adaptive evolution of metabolic pathways in Drosophila
    J M Flowers
    Department of Ecology and Evolution, Stony Brook University, NY, USA
    Mol Biol Evol 24:1347-54. 2007
  10. ncbi Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria
    Selim Terhzaz
    Institute of Biomedical and Life Sciences, Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, Scotland, UK
    J Biol Chem 281:18849-58. 2006

Scientific Experts

  • Christian Schlotterer
  • B Hausdorf
  • Jonathan M Flowers
  • Evy Vierstraete
  • Simon Collier
  • Carolina Bartolomé
  • Ming Gao
  • Gabriela Prado Paludo
  • Arunachalam Vinayagam
  • Claire de la Cova
  • Samuel E Schriner
  • Jessica L Buescher
  • Helen A Lindsay
  • Selim Terhzaz
  • Kenji Nakahara
  • Efe Sezgin
  • Karina Rodrigues Lorenzatto
  • Patrick McCluskey
  • Alexey L Arkov
  • Travis C Thomson
  • Shikui Tu
  • Henrique Bunselmeyer Ferreira
  • Diego Bonatto
  • Christina A Jackson
  • Zhiping Weng
  • T Michael Creed
  • Melanie D Ohi
  • Yanyan Lin
  • Paul Lasko
  • Sudan N Loganathan
  • Charles Roesel
  • JONATHAN ZIRIN
  • Paola Bellosta
  • Bahar Yilmazel
  • Nanami Senoo-Matsuda
  • Marcello Ziosi
  • D Christine Wu
  • Catarina M Quinzii
  • Yanhui Hu
  • Stephanie E Mohr
  • Laura A Johnston
  • Norbert Perrimon
  • Anastasia A Samsonova
  • Ralph A Neumüller
  • Steven Maler
  • Madeline Keleher
  • Kathyrn T Salvadora
  • Kevin Lee
  • Mahtab Jafari
  • Christina A Wilson
  • Tieming Lang
  • Alexander Nam
  • Thomas J Baranski
  • Jennifer G Duncan
  • Laura P Musselman
  • Stéphanie Truong
  • Thomas Lee
  • D Bachtrog
  • B Harr
  • T Xie
  • Kevin M C O'Dell
  • Howard T Jacobs
  • Richard Baines
  • Kathryn Lilley
  • Richard ffrench-Constant
  • Kathryn S Lilley
  • Adrian K Allan
  • Tony D Southall
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  • Kevin Kim
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  • Chen Tseh Zhu
  • Walter F Eanes
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  • Yihao Duan
  • D Ding
  • M Imhof
  • M Agis
  • J F Santaren
  • J Vandekerckhove
  • M Puype
  • A Garcia-Bellido
  • J Van Damme

Detail Information

Publications22

  1. doi Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase
    Gabriela Prado Paludo
    Laboratório de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Comput Biol Chem 58:1-8. 2015
    Glycolytic enzymes, such as enolase, have been described as multifunctional complex proteins that also display non-glycolytic activities, termed moonlighting functions...
  2. pmc Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements
    Ming Gao
    Department of Biological Sciences, Murray State University, Murray, KY, USA
    EMBO Rep 16:379-86. 2015
    ..Our data indicate that germ cells, similarly to stem cells and tumor cells, might prefer to produce energy through the glycolytic pathway, thus linking a particular metabolism to pluripotency...
  3. pmc Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability
    Claire de la Cova
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University Medical Center, 701 West 168th Street, New York, NY 10032, USA
    Cell Metab 19:470-83. 2014
    ..Our findings suggest that the initial confrontation between precancerous and WT cells could enhance cancer cell fitness and promote tumor progression...
  4. pmc Integrating protein-protein interaction networks with phenotypes reveals signs of interactions
    Arunachalam Vinayagam
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 11:94-9. 2014
    ..We identified an unexpected role for the metabolic enzymes enolase and aldo-keto reductase as positive and negative regulators of proteolysis, respectively...
  5. pmc Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction
    Samuel E Schriner
    Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e63886. 2013
    ..The latter conclusion is especially relevant given the limited potential for DR to improve human health and lifespan, and presents R. rosea as a potential viable candidate to treat aging and age-related diseases in humans...
  6. pmc Evidence for transgenerational metabolic programming in Drosophila
    Jessica L Buescher
    Department of Pediatrics, and
    Dis Model Mech 6:1123-32. 2013
    ..Our data indicate that nutritional programming mechanisms could be highly conserved and support the use of Drosophila as a model for evaluating the underlying genetic and epigenetic contributions to this phenomenon. ..
  7. pmc The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis
    Simon Collier
    Department of Biological Sciences, Marshall University, Huntington, West Virginia 25755, USA
    Genetics 169:2035-45. 2005
    ..We show that the fritz gene product functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites...
  8. pmc The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic
    Helen A Lindsay
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QR, UK
    Genetics 180:873-84. 2008
    ..Therefore, in the absence of suitable vertebrate models, Ocd provides a system in which genetic, molecular, physiological, and behavioral tools can be exploited to determine mechanisms underlying sodium channel periodic paralyses...
  9. ncbi Adaptive evolution of metabolic pathways in Drosophila
    J M Flowers
    Department of Ecology and Evolution, Stony Brook University, NY, USA
    Mol Biol Evol 24:1347-54. 2007
    ..The data suggest that adaptive evolution of G6P branch point enzymes may have special significance in metabolic adaptation...
  10. ncbi Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria
    Selim Terhzaz
    Institute of Biomedical and Life Sciences, Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, Scotland, UK
    J Biol Chem 281:18849-58. 2006
    ..The results highlight the dynamic nature and both spatial and temporal heterogeneity of calcium signaling possible in differentiated, organotypic cells and provide a new model for neuroendocrine control of V-ATPase...
  11. pmc The nucleotide sequence of a Drosophila melanogaster enolase gene
    J G Bishop
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218
    Nucleic Acids Res 18:191. 1990
  12. pmc Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda
    Carolina Bartolomé
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, UK
    Genetics 169:1495-507. 2005
    ..The joint intensity of selection and biased gene conversion, in terms of the product of effective population size and the sum of the selection and conversion coefficients, was estimated to be approximately 0.65...
  13. pmc Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogaster
    Efe Sezgin
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
    Genetics 168:923-31. 2004
    ..melanogaster of latitudinal clines for 23 SNPs embedded in 13 genes (Pgi, Gapdh1, UGPase, Pglym78, Pglym87, Eno, Men, Gdh, Sod, Pgk, Mdh1, TreS, Treh) representing various metabolic enzymes...
  14. ncbi The instantly released Drosophila immune proteome is infection-specific
    Evy Vierstraete
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Louvain, Belgium
    Biochem Biophys Res Commun 317:1052-60. 2004
    ..Next to known immune proteins, unannotated proteins were identified such as CG4306 protein, which has homologues with unknown function in all metazoan genome databases available today...
  15. pmc A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph
    Evy Vierstraete
    Laboratory of Developmental Physiology, Genomics and Proteomics, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 101:470-5. 2004
    ..Determining the function of all of these immune-induced proteins represents an exciting challenge for increasing our knowledge of insect immunity...
  16. ncbi Early evolution of the bilateria
    B Hausdorf
    Zoologisches Institut und Zoologisches Museum, Universitat Hamburg, Martin Luther King Platz 3, D 20146 Hamburg, Germany
    Syst Biol 49:130-42. 2000
    ..Estimations of the divergence times show that the major bilaterian phyla did not originate in an explosive radiation during the Cambrian but rather that the Bilateria have a several hundred million years long Precambrian history...
  17. ncbi Microsatellite analysis of Drosophila melanogaster populations along a microclimatic contrast at lower Nahel Oren canyon, Mount Carmel, Israel
    Christian Schlotterer
    Institut fur Tierzucht und Genetik, Vienna University of Veterinary Medicine, Josef Baumann Gasse 1, 1210 Vienna, Austria
    Mol Biol Evol 19:563-8. 2002
    ..melanogaster populations was low (F(ST) = 0.0012). Also a tree of individuals based on the proportion of shared alleles and a model-based clustering method provided no evidence for population substructuring...
  18. ncbi Investigating 42 candidate orthologous protein groups by molecular evolutionary analysis on genome scale
    T Xie
    Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, China
    Gene 261:305-10. 2000
    ..The result could imply that the classical one-to-one orthology might be not as common as typically accepted and automated similarity-based methods should be used with caution when accurate orthology/paralogy discrimination is required...
  19. ncbi Microsatellite variability differs between dinucleotide repeat motifs-evidence from Drosophila melanogaster
    D Bachtrog
    Institut fur Tierzucht und Genetik, Vienna, Austria
    Mol Biol Evol 17:1277-85. 2000
    ..Similar differences in mutation rates were obtained by an alternative method which estimates microsatellite mutation rates from their genomic length distribution...
  20. pmc Long microsatellite alleles in Drosophila melanogaster have a downward mutation bias and short persistence times, which cause their genome-wide underrepresentation
    B Harr
    Institut fur Tierzucht und Genetik, Veterinärmedizinische Universität Wien, 1210 Vienna, Austria
    Genetics 155:1213-20. 2000
    ..We propose that species-specific, size-dependent mutation spectra of microsatellite alleles may provide a general mechanism to account for the observed differences in microsatellite length between species...
  21. ncbi Identification of Drosophila wing imaginal disc proteins by two-dimensional gel analysis and microsequencing
    J F Santaren
    Centro de Biologia Molecular Severo Ochoa, UAM CSIC, Universidad Autonoma de Madrid, Spain
    Exp Cell Res 206:220-6. 1993
    ..As an illustration we present 12 of them: 8 corresponding to proteins already known in Drosophila and the 4 showing homologies with proteins of other organisms...
  22. pmc Targets of microRNA regulation in the Drosophila oocyte proteome
    Kenji Nakahara
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 102:12023-8. 2005
    ..The preponderance of genes that control global protein abundance suggests this process is under tight control by miRNAs at the onset of fertilization...