Genomes and Genes
Gene Symbol: Eno
Alias: BEST:LD15491, CG17654, CT32526, Dmel\CG17654, ENOA, Eno2, T18, anon-WO0153538.76, eno, CG17654 gene product from transcript CG17654-RE, CG17654-PA, CG17654-PB, CG17654-PC, CG17654-PD, CG17654-PE, CG17654-PF, Eno-PA, Eno-PB, Eno-PC, Eno-PD, Eno-PE, Eno-PF, enolase, phosphopyruvate hydratase
Species: fruit fly
- Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolaseGabriela Prado Paludo
Laboratório de Genômica Estrutural e Funcional, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
Comput Biol Chem 58:1-8. 2015Glycolytic enzymes, such as enolase, have been described as multifunctional complex proteins that also display non-glycolytic activities, termed moonlighting functions...
- Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elementsMing Gao
Department of Biological Sciences, Murray State University, Murray, KY, USA
EMBO Rep 16:379-86. 2015..Our data indicate that germ cells, similarly to stem cells and tumor cells, might prefer to produce energy through the glycolytic pathway, thus linking a particular metabolism to pluripotency...
- Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viabilityClaire de la Cova
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University Medical Center, 701 West 168th Street, New York, NY 10032, USA
Cell Metab 19:470-83. 2014..Our findings suggest that the initial confrontation between precancerous and WT cells could enhance cancer cell fitness and promote tumor progression...
- Integrating protein-protein interaction networks with phenotypes reveals signs of interactionsArunachalam Vinayagam
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Nat Methods 11:94-9. 2014..We identified an unexpected role for the metabolic enzymes enolase and aldo-keto reductase as positive and negative regulators of proteolysis, respectively...
- Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restrictionSamuel E Schriner
Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California, United States of America
PLoS ONE 8:e63886. 2013..The latter conclusion is especially relevant given the limited potential for DR to improve human health and lifespan, and presents R. rosea as a potential viable candidate to treat aging and age-related diseases in humans...
- Evidence for transgenerational metabolic programming in DrosophilaJessica L Buescher
Department of Pediatrics, and
Dis Model Mech 6:1123-32. 2013..Our data indicate that nutritional programming mechanisms could be highly conserved and support the use of Drosophila as a model for evaluating the underlying genetic and epigenetic contributions to this phenomenon. ..
- The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermisSimon Collier
Department of Biological Sciences, Marshall University, Huntington, West Virginia 25755, USA
Genetics 169:2035-45. 2005..We show that the fritz gene product functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites...
- The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralyticHelen A Lindsay
Department of Biochemistry, University of Cambridge, Cambridge CB2 1QR, UK
Genetics 180:873-84. 2008..Therefore, in the absence of suitable vertebrate models, Ocd provides a system in which genetic, molecular, physiological, and behavioral tools can be exploited to determine mechanisms underlying sodium channel periodic paralyses...
- Adaptive evolution of metabolic pathways in DrosophilaJ M Flowers
Department of Ecology and Evolution, Stony Brook University, NY, USA
Mol Biol Evol 24:1347-54. 2007..The data suggest that adaptive evolution of G6P branch point enzymes may have special significance in metabolic adaptation...
- Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondriaSelim Terhzaz
Institute of Biomedical and Life Sciences, Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, Scotland, UK
J Biol Chem 281:18849-58. 2006..The results highlight the dynamic nature and both spatial and temporal heterogeneity of calcium signaling possible in differentiated, organotypic cells and provide a new model for neuroendocrine control of V-ATPase...
- The nucleotide sequence of a Drosophila melanogaster enolase geneJ G Bishop
Department of Biology, Johns Hopkins University, Baltimore, MD 21218
Nucleic Acids Res 18:191. 1990
- Patterns of selection on synonymous and nonsynonymous variants in Drosophila mirandaCarolina Bartolomé
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, UK
Genetics 169:1495-507. 2005..The joint intensity of selection and biased gene conversion, in terms of the product of effective population size and the sum of the selection and conversion coefficients, was estimated to be approximately 0.65...
- Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogasterEfe Sezgin
Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
Genetics 168:923-31. 2004..melanogaster of latitudinal clines for 23 SNPs embedded in 13 genes (Pgi, Gapdh1, UGPase, Pglym78, Pglym87, Eno, Men, Gdh, Sod, Pgk, Mdh1, TreS, Treh) representing various metabolic enzymes...
- The instantly released Drosophila immune proteome is infection-specificEvy Vierstraete
Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Louvain, Belgium
Biochem Biophys Res Commun 317:1052-60. 2004..Next to known immune proteins, unannotated proteins were identified such as CG4306 protein, which has homologues with unknown function in all metazoan genome databases available today...
- A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymphEvy Vierstraete
Laboratory of Developmental Physiology, Genomics and Proteomics, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
Proc Natl Acad Sci U S A 101:470-5. 2004..Determining the function of all of these immune-induced proteins represents an exciting challenge for increasing our knowledge of insect immunity...
- Early evolution of the bilateriaB Hausdorf
Zoologisches Institut und Zoologisches Museum, Universitat Hamburg, Martin Luther King Platz 3, D 20146 Hamburg, Germany
Syst Biol 49:130-42. 2000..Estimations of the divergence times show that the major bilaterian phyla did not originate in an explosive radiation during the Cambrian but rather that the Bilateria have a several hundred million years long Precambrian history...
- Microsatellite analysis of Drosophila melanogaster populations along a microclimatic contrast at lower Nahel Oren canyon, Mount Carmel, IsraelChristian Schlotterer
Institut fur Tierzucht und Genetik, Vienna University of Veterinary Medicine, Josef Baumann Gasse 1, 1210 Vienna, Austria
Mol Biol Evol 19:563-8. 2002..melanogaster populations was low (F(ST) = 0.0012). Also a tree of individuals based on the proportion of shared alleles and a model-based clustering method provided no evidence for population substructuring...
- Investigating 42 candidate orthologous protein groups by molecular evolutionary analysis on genome scaleT Xie
Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, China
Gene 261:305-10. 2000..The result could imply that the classical one-to-one orthology might be not as common as typically accepted and automated similarity-based methods should be used with caution when accurate orthology/paralogy discrimination is required...
- Microsatellite variability differs between dinucleotide repeat motifs-evidence from Drosophila melanogasterD Bachtrog
Institut fur Tierzucht und Genetik, Vienna, Austria
Mol Biol Evol 17:1277-85. 2000..Similar differences in mutation rates were obtained by an alternative method which estimates microsatellite mutation rates from their genomic length distribution...
- Long microsatellite alleles in Drosophila melanogaster have a downward mutation bias and short persistence times, which cause their genome-wide underrepresentationB Harr
Institut fur Tierzucht und Genetik, Veterinärmedizinische Universität Wien, 1210 Vienna, Austria
Genetics 155:1213-20. 2000..We propose that species-specific, size-dependent mutation spectra of microsatellite alleles may provide a general mechanism to account for the observed differences in microsatellite length between species...
- Identification of Drosophila wing imaginal disc proteins by two-dimensional gel analysis and microsequencingJ F Santaren
Centro de Biologia Molecular Severo Ochoa, UAM CSIC, Universidad Autonoma de Madrid, Spain
Exp Cell Res 206:220-6. 1993..As an illustration we present 12 of them: 8 corresponding to proteins already known in Drosophila and the 4 showing homologies with proteins of other organisms...
- Targets of microRNA regulation in the Drosophila oocyte proteomeKenji Nakahara
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Proc Natl Acad Sci U S A 102:12023-8. 2005..The preponderance of genes that control global protein abundance suggests this process is under tight control by miRNAs at the onset of fertilization...