ena

Summary

Gene Symbol: ena
Description: enabled
Alias: CG15112, Dmel\CG15112, ENA/VASP, Ena, Enb, VASP, Vasp, enb, l(2)02029, CG15112 gene product from transcript CG15112-RG, CG15112-PA, CG15112-PB, CG15112-PC, CG15112-PD, CG15112-PE, CG15112-PF, CG15112-PG, VASP, ena-PA, ena-PB, ena-PC, ena-PD, ena-PE, ena-PF, ena-PG
Species: fruit fly

Top Publications

  1. ncbi Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions
    R L Bennett
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Development 116:953-66. 1992
  2. ncbi Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Science 248:857-60. 1990
  3. ncbi enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison 53706
    Genes Dev 9:521-33. 1995
  4. ncbi Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    F B Gertler
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:227-39. 1996
  5. pmc Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled
    A R Comer
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Madison, 53706, USA
    Mol Cell Biol 18:152-60. 1998
  6. pmc Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains
    S M Ahern-Djamali
    McArdle Laboratory for Cancer Research and Laboratory of Genetics University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Mol Biol Cell 9:2157-71. 1998
  7. ncbi The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
    Z Wills
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 22:301-12. 1999
  8. pmc Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled
    S M Ahern-Djamali
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 96:4977-82. 1999
  9. ncbi Cycling, stressed-out and nervous: cellular functions of c-Abl
    R A Van Etten
    Center for Blood Research, Dept of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 9:179-86. 1999
  10. ncbi Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding
    E C Liebl
    Department of Biology, Denison University, Granville, Ohio 43023, USA
    Neuron 26:107-18. 2000

Scientific Experts

Detail Information

Publications112 found, 100 shown here

  1. ncbi Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions
    R L Bennett
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Development 116:953-66. 1992
    ..The expression patterns and mutant phenotypes indicate a role for abl in establishing and maintaining cell-cell interactions...
  2. ncbi Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Science 248:857-60. 1990
    ..the lethality caused by the absence of abl function have been isolated, and all three map to the gene enabled (ena)...
  3. ncbi enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties
    F B Gertler
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, Madison 53706
    Genes Dev 9:521-33. 1995
    ..mutations that suppress the lethality of Abl mutations in Drosophila identified alleles of only one gene, enabled (ena)...
  4. ncbi Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
    F B Gertler
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Cell 87:227-39. 1996
    ..We have identified two murine proteins, Mena and Evl, that are highly related to Enabled as well as VASP (Vasodilator-Stimulated Phosphoprotein)...
  5. pmc Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled
    A R Comer
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Madison, 53706, USA
    Mol Cell Biol 18:152-60. 1998
    Drosophila Enabled (Ena) is a member of a family of cytoskeleton-associated proteins including mammalian vasodilator-stimulated phosphoprotein and murine Enabled that regulate actin cytoskeleton assembly...
  6. pmc Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains
    S M Ahern-Djamali
    McArdle Laboratory for Cancer Research and Laboratory of Genetics University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Mol Biol Cell 9:2157-71. 1998
    ..the Abelson tyrosine kinase and, more recently, as a member of the Ena/human vasodilator-stimulated phosphoprotein (VASP) family of proteins...
  7. ncbi The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
    Z Wills
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 22:301-12. 1999
    ..We also show that the Abl phosphoprotein substrate Enabled (Ena) is required for choice point navigation...
  8. pmc Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled
    S M Ahern-Djamali
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 96:4977-82. 1999
    Drosophila Enabled (Ena) was first identified as a genetic suppressor of mutations in the Abelson tyrosine kinase and subsequently was shown to be a member of the Ena/vasodilator-stimulated phosphoprotein family of proteins...
  9. ncbi Cycling, stressed-out and nervous: cellular functions of c-Abl
    R A Van Etten
    Center for Blood Research, Dept of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Trends Cell Biol 9:179-86. 1999
    ..This review summarizes our current understanding of the many facets of c-Abl biology, emphasizing recent studies on Drosophila and mammalian Abl...
  10. ncbi Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding
    E C Liebl
    Department of Biology, Denison University, Granville, Ohio 43023, USA
    Neuron 26:107-18. 2000
    ..Dosage-sensitive interactions between trio and Abl, failed axon connections (fax), and enabled (ena) indicate that Trio is integrated into common signaling networks with these gene products...
  11. ncbi Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
    G J Bashaw
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 101:703-15. 2000
    ..Here, we present genetic and biochemical evidence that the Abelson (Abl) tyrosine kinase and its substrate Enabled (Ena) play direct and opposing roles in Robo signal transduction...
  12. ncbi Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance
    J H Simpson
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 28:753-66. 2000
    ..The robo,robo2 double mutant is largely identical to slit...
  13. ncbi Spatial control of the actin cytoskeleton in Drosophila epithelial cells
    B Baum
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Cell Biol 3:883-90. 2001
    ..of Adenylyl Cyclase Associated Proteins-functions specifically to limit actin-filament formation catalysed by Ena at apical cell junctions. The Abl tyrosine kinase also collaborates in this process...
  14. pmc Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration
    Joseph J Loureiro
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Mol Biol Cell 13:2533-46. 2002
    The Ena/vasodilator-stimulated phosphoprotein (VASP) protein family is implicated in the regulation of a number of actin-based cellular processes, including lamellipodial protrusion necessary for whole cell translocation...
  15. ncbi Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway
    Daniel Crowner
    Division of Basic Sciences and Program in Developmental Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North, Seattle, WA 98109, USA
    Curr Biol 13:967-72. 2003
    ..We suggest that the Notch/Abl interaction promotes the turning of ISNb axons by attenuating the Abl-dependent adhesion of ISNb axons to their substratum, thus releasing the axons to respond to attraction from target muscles...
  16. ncbi Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions
    Patricia Kunda
    Ludwig Institute for Cancer Research University College Branch, London, UK
    Curr Biol 13:1867-75. 2003
    ..SCAR and WASP then activate the Arp2/3 complex to nucleate the formation of new actin filaments, which through polymerization exert a protrusive force on the membrane...
  17. pmc Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled
    Elizabeth E Grevengoed
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:1267-79. 2003
    ..Abl acts at least in part via the actin regulator Enabled (Ena), but the mechanism by which Abl regulates Ena is unknown...
  18. ncbi Rho GTPases regulate axon growth through convergent and divergent signaling pathways
    Julian Ng
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 44:779-93. 2004
    ..These genetic analyses reveal convergent and divergent pathways from Rho GTPases to the cytoskeleton during axon growth in vivo and suggest that different developmental outcomes could be achieved by biases in pathway selection...
  19. ncbi The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila
    David J Forsthoefel
    The Ohio State University, Department of Molecular Genetics and Center for Molecular Neurobiology, Columbus, OH 43210, USA
    Development 132:1983-94. 2005
    ..Abelson tyrosine kinase (Abl), the guanine nucleotide-exchange factor Trio, and the Abl substrate Enabled (Ena), all regulate axon pathfinding at the Drosophila embryonic CNS midline...
  20. pmc Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1
    MaryAnn Martin
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Mol Biol Cell 16:4225-30. 2005
    ..A concomitant reduction in ena dosage rescued those defects. These results suggest that Ena/VASP, when not inhibited by the Abl pathway, can bind Khc and reduce its transport activity in axons.
  21. ncbi Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila
    Wenjun Li
    Gladstone Institute of Neurological Disease, San Francisco, California, USA
    Dev Dyn 234:512-22. 2005
    ..Enabled (Ena), a substrate for Abl, promotes the formation of both dendritic branches and actin-rich spine-like protrusions of ..
  22. ncbi Abi activates WASP to promote sensory organ development
    Sven Bogdan
    Institut fur Neurobiologie, Universitat Munster, Badestr 9, D 48149 Munster, Germany
    Nat Cell Biol 7:977-84. 2005
    ..Thus, in vivo Abi may set the balance between WASP and WAVE in different actin-based developmental processes...
  23. ncbi The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development
    Karl G Johnson
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Neuron 49:517-31. 2006
    ....
  24. ncbi Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila
    Julie Gates
    Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Development 134:2027-39. 2007
    ..Among these are Enabled (Ena)/VASP proteins, anti-Capping proteins that influence fibroblast migration, growth cone motility, and keratinocyte cell ..
  25. pmc Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila
    Traci L Stevens
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Biol Cell 19:378-93. 2008
    ..These data provide new insight into how regulated Abl activity helps direct normal development and into possible biological functions of Bcr-Abl...
  26. doi Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis
    Catarina C F Homem
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 135:1005-18. 2008
    ..These effects also are mediated through coordinated effects on myosin activity and adhesion, suggesting a common mechanism for Diaphanous action during morphogenesis...
  27. pmc Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP
    Léa Trichet
    Laboratoire Matière et Systèmes Complexes, Centre National de la Recherche Scientifique, Paris 7, 75205 Paris Cedex 13, France
    J Cell Biol 181:19-25. 2008
    ..Here we explain how and why Drosophila enabled/vasodilator stimulated phosphoprotein (Ena/VASP) proteins are candidates for driving this cytoskeleton modulation under the membrane.
  28. pmc Prominent actin fiber arrays in Drosophila tendon cells represent architectural elements different from stress fibers
    Juliana Alves-Silva
    Faculty of Life Sciences, Wellcome Trust Centre of Cell Matrix Research, Manchester M13 9PT, United Kingdom
    Mol Biol Cell 19:4287-97. 2008
    ..Features reported here and elsewhere for tendon cells are reminiscent of the structural and molecular features of support cells in the inner ear of vertebrates, and they might have potential translational value...
  29. pmc Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation
    Ekaterina Lyulcheva
    Department of Zoology, Oxford University, South Parks Road, Oxford OX1 3PS, UK
    Dev Cell 15:680-90. 2008
    MIG-10/RIAM/lamellipodin (MRL) proteins link activated Ras-GTPases with actin regulatory Ena/VASP proteins to induce local changes in cytoskeletal dynamics and cell motility...
  30. doi Formin proteins of the DAAM subfamily play a role during axon growth
    Tamás Matusek
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
    J Neurosci 28:13310-9. 2008
    ....
  31. pmc Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis
    Julie Gates
    Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Dev Biol 333:90-107. 2009
    ..We used oogenesis to explore developmental roles of two important actin regulators: Enabled/VASP proteins and Capping protein...
  32. doi Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis
    Tzu Yang Lin
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan
    Development 136:3099-107. 2009
    ..Double heterozygosity for abi and enabled (ena) also suppresses the synaptic overgrowth phenotypes of Abl mutants, suggesting that Abi acts cooperatively with Ena ..
  33. pmc Exploring the roles of diaphanous and enabled activity in shaping the balance between filopodia and lamellipodia
    Catarina C F Homem
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Biol Cell 20:5138-55. 2009
    ..Here we use Drosophila leading-edge (LE) cells to explore how Diaphanous (Dia)-related formins and Ena/VASP proteins cooperate in this process...
  34. pmc The integrin adhesion complex changes its composition and function during morphogenesis of an epithelium
    Isabelle Delon
    Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    J Cell Sci 122:4363-74. 2009
    ..Molecular variation of the integrin complex is thus a key component of developmentally programmed morphogenesis...
  35. pmc Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms
    Carlos M Loya
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 6:897-903. 2009
    ..Given that miR-SPs rely on a bipartite modular expression system, they could be used to elucidate the endogenous function of microRNAs in any species in which conditional expression can be achieved...
  36. doi Drosophila growth cones: a genetically tractable platform for the analysis of axonal growth dynamics
    Natalia Sánchez-Soriano
    Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester M13 9PT, United Kingdom
    Dev Neurobiol 70:58-71. 2010
    ..We demonstrate these events to be mediated by the actin-MT linking factor Short stop, thus identifying an essential molecular player in this context...
  37. pmc Disabled is a bona fide component of the Abl signaling network
    Jeong K Song
    Axon Guidance and Neural Connectivity Unit, Basic Neuroscience Program, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3719-27. 2010
    ..interacts genetically with mutations in Abl, and with mutations in the Abl accessory factors trio and enabled (ena)...
  38. pmc Ena drives invasive macrophage migration in Drosophila embryos
    Philippa K Tucker
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Dis Model Mech 4:126-34. 2011
    ..Upregulation of Mena, a member of the evolutionarily conserved Ena/VASP family of actin cytoskeletal regulators, promotes metastasis and invasive motility of breast cancer cells in vivo...
  39. pmc Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure
    Caroline Laplante
    Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
    J Cell Biol 192:335-48. 2011
    ..The planar polarized distribution of Ed in the DME cells thus provides a spatial cue that polarizes the DME cell actin cytoskeleton, defining the epidermal leading edge and establishing its contractile properties...
  40. pmc How Notch establishes longitudinal axon connections between successive segments of the Drosophila CNS
    Irina Kuzina
    National Institute of Neurological Disorders and Stroke and National Human Genome Research Institute NIH, Bethesda, MD 20892, USA
    Development 138:1839-49. 2011
    ..This propels the axons as they establish the connection between successive segments...
  41. pmc Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model
    Catarina Gonçalves-Pimentel
    Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester, United Kingdom
    PLoS ONE 6:e18340. 2011
    ..Our genetic data support a model in which Arp2/3 and DAAM cooperate in a common mechanism of filopodia formation that essentially depends on enabled, and is regulated through profilin activity at different steps...
  42. doi Notch-mediated repression of bantam miRNA contributes to boundary formation in the Drosophila wing
    Isabelle Becam
    Institute for Research in Biomedicine IRB Barcelona, Parc Cientific de Barcelona, Baldiri Reixac, 10 12, 08028 Barcelona, Spain
    Development 138:3781-9. 2011
    ....
  43. pmc The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells
    Eliana P Lucas
    Epithelial Biology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3LY, England, UK
    J Cell Biol 201:875-85. 2013
    ..Instead, Warts phosphorylates and inhibits the actin regulator Ena to activate F-actin Capping protein activity on inner membranes and thereby restricts F-actin polymerization mainly ..
  44. pmc Filopodia-like actin cables position nuclei in association with perinuclear actin in Drosophila nurse cells
    Sven Huelsmann
    Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Dev Cell 26:604-15. 2013
    ..We provide a revised model for how actin structures position nuclei in nurse cells, employing evolutionary conserved machinery...
  45. doi Drosophila pupal macrophages--a versatile tool for combined ex vivo and in vivo imaging of actin dynamics at high resolution
    Moritz Sander
    Institute for Neurobiology, University of Munster, Germany
    Eur J Cell Biol 92:349-54. 2013
    ....
  46. pmc Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo
    Colleen G Bilancia
    Biology Department, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Dev Cell 28:394-408. 2014
    ..We characterized Diaphanous (Dia) and Enabled (Ena) as a model, using complementary approaches: cell culture, biophysical analysis, and Drosophila morphogenesis...
  47. pmc Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin
    Jonathan D Winkelman
    Departments of Molecular Genetics and Cell Biology, and Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637
    Proc Natl Acad Sci U S A 111:4121-6. 2014
    ..Drosophila melanogaster Enabled (Ena) is a member of the Ena/vasodilator-stimulated phosphoprotein protein family, which facilitates the assembly of ..
  48. pmc Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning
    Stephane Vincent
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Development 135:2767-75. 2008
    ..The combination of independent progression of cell identity and arrest of progression by signals facilitates accurate patterning of an extremely plastic developing epidermis...
  49. pmc Abelson kinase regulates epithelial morphogenesis in Drosophila
    E E Grevengoed
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 155:1185-98. 2001
    ..Further, we show that the Abl target Enabled (Ena), a modulator of actin dynamics, is involved with Abl in morphogenesis...
  50. doi Plexin a-semaphorin-1a reverse signaling regulates photoreceptor axon guidance in Drosophila
    Li Yu
    McGill Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    J Neurosci 30:12151-6. 2010
    ..Epistasis analysis suggests that PlexA functions upstream of semala. And PlexA and sema1a interact genetically with Rho1. We propose that PlexA regulates Semala reverse signaling in the Drosophila visual system...
  51. doi The Drosophila homologue of SRF acts as a boosting mechanism to sustain FGF-induced terminal branching in the tracheal system
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, c Baldiri Reixac, 10 12, 08028 Barcelona, Spain
    Development 138:1269-74. 2011
    ..Our results indicate that DSRF acts as an amplifying step to sustain the progression of terminal branch elongation even in the wild-type conditions of FGF signalling...
  52. pmc Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila
    Sung Bae Lee
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 108:16795-800. 2011
    ..Together, these findings suggest that specific actin cytoskeletal alterations that alter dendrite morphology and function may contribute to the pathogenesis of at least a subset of polyQ disorders, including SCA3 and SCA1...
  53. pmc MENA is a transcriptional target of the Wnt/beta-catenin pathway
    Ayaz Najafov
    Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey
    PLoS ONE 7:e37013. 2012
    ..melanogaster eyeful and sensitized eye cancer fly models resulted in increased tumor and metastasis formations. In summary, our study identifies MENA as novel nexus for the Wnt/β-catenin and the Notch signalling cascades...
  54. pmc Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton
    Xing Judy Chen
    Cell Motility Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Dev Cell 30:569-84. 2014
    Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motility by virtue of their ability to independently promote actin polymerization...
  55. doi Drosophila Cip4/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR/WAVE
    Robert Fricke
    Institut fur Neurobiologie, Wilhelms University Münster, 48149 Munster, Germany
    Curr Biol 19:1429-37. 2009
    ..The F-BAR-domain-containing proteins are prime candidates to couple actin dynamics and membrane trafficking in different morphogenetic processes...
  56. pmc Abelson tyrosine kinase is required for Drosophila photoreceptor morphogenesis and retinal epithelial patterning
    Wenjun Xiong
    Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois, USA
    Dev Dyn 240:1745-55. 2011
    ..Loss of abl does not alter expression or localization of Enabled (Ena) nor does heterozygosity for ena dominantly suppress the abl phenotypes, suggesting the downstream effector ..
  57. doi Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila
    Dominique Förster
    Institute of Molecular Life Sciences IMLS, Ph D Program in Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland
    Nat Cell Biol 14:526-34. 2012
    ..Whereas exocytosis-dependent membrane growth drives circumferential tube expansion, Src42A is required to orient membrane growth in the axial dimension of the tube...
  58. doi The actin-binding protein Canoe/AF-6 forms a complex with Robo and is required for Slit-Robo signaling during axon pathfinding at the CNS midline
    Jana Slováková
    Instituto de Neurociencias, CSIC UMH, 03550 Sant Joan d Alacant, Spain
    J Neurosci 32:10035-44. 2012
    ..Our data argue that Cno is a novel regulator of the Slit-Robo signaling pathway, crucial for regulating the subcellular localization of Robo and for transducing its signaling to the actin cytoskeleton during axon guidance at the midline...
  59. pmc The Drosophila actin regulator ENABLED regulates cell shape and orientation during gonad morphogenesis
    Hiroko Sano
    HHMI and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University Medical Center, New York, New York, United States of America
    PLoS ONE 7:e52649. 2012
    ..This process is disrupted in mutants of the actin regulator, enabled (ena)...
  60. ncbi Drosophila abl and genetic redundancy in signal transduction
    F M Hoffmann
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Trends Genet 7:351-5. 1991
    ..Molecular isolation and analysis of the genes identified by these second-site mutations should define the molecular basis for the genetic redundancy...
  61. pmc Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells
    R S Lamb
    Developmental, Cellular, and Molecular Biology Group, Duke University, Durham, North Carolina 27708 1000, USA
    Mol Biol Cell 9:3505-19. 1998
    ..1 superfamily members. These studies provide insights into a range of in vivo functions for coracle in developing embryos and adults...
  62. ncbi Dominant effects of the bcr-abl oncogene on Drosophila morphogenesis
    F J Fogerty
    Department of Medicine, University of Wisconsin Comprehensive Cancer Center, Madison 53706, USA
    Oncogene 18:219-32. 1999
    ..Drosophila, therefore, is a suitable model system to identify Bcr-Abl interactions important for signal transduction and oncogenesis...
  63. ncbi Stop or go in the target zone
    S Kunes
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Neuron 22:639-40. 1999
  64. ncbi Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity
    J L Juang
    National Health Research Institute, 128 Yen Chiu Yuan Road, Sec 2, Taipei, Taiwan
    Oncogene 18:5138-47. 1999
    ..Both proteins activate the kinase activity of Abl as assayed by phosphorylation of the Drosophila Enabled (Ena) protein. Removal of the dAbi SH3 domain eliminates dAbi's activation of Abl kinase activity...
  65. pmc Genes regulating dendritic outgrowth, branching, and routing in Drosophila
    F B Gao
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California at San Francisco, San Francisco, California 94143 0725, USA
    Genes Dev 13:2549-61. 1999
    ..These findings begin to reveal the molecular mechanisms controlling dendritic morphogenesis...
  66. ncbi Trio quartet in D. (melanogaster)
    L Luo
    Department of Biological Sciences, Stanford University, California 94305, USA
    Neuron 26:1-2. 2000
  67. ncbi Protein-protein interactions define specificity in signal transduction
    T Pawson
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Genes Dev 14:1027-47. 2000
  68. ncbi Putting on the brakes: a negative regulatory function for Ena/VASP proteins in cell migration
    L M Machesky
    School of Biosciences, Division of Molecular and Cell Biology, University of Birmingham, United Kingdom
    Cell 101:685-8. 2000
  69. ncbi The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance
    J Bateman
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 114:1973-80. 2001
    ..Future studies of these mechanisms promise to yield insights not only into neural development but also into the ongoing function and remodeling of the adult nervous system...
  70. ncbi ribbon encodes a novel BTB/POZ protein required for directed cell migration in Drosophila melanogaster
    P L Bradley
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, Maryland 21205 2196, USA
    Development 128:3001-15. 2001
    ..Directed cell migration of the salivary gland and dorsal epidermis are also affected in ribbon mutants, suggesting that conserved mechanisms may be employed to orient cell migrations in multiple tissues during development...
  71. ncbi Four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg
    G R Buckles
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Development 128:3533-42. 2001
    ..Thus, four-jointed may bridge the gap between the signals that direct morphogenesis and those that carry it out...
  72. ncbi The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis
    K Shim
    Howard Hughes Medical Institute and Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
    Development 128:4923-33. 2001
    ..We propose that Rib is a key regulator of epithelial morphogenesis that promotes migration and morphogenesis of the tracheal cell bodies and apical surface and other morphogenetic movements...
  73. ncbi Synaptogenesis: insights from worm and fly
    Yishi Jin
    Department of Molecular, Cell, Developmental Biology, Howard Hughes Medical Institute, University of California, Santa Cruz, California 95064, USA
    Curr Opin Neurobiol 12:71-9. 2002
    ....
  74. ncbi Axon guidance: the cytoplasmic tail
    Bharatkumar N Patel
    Program in Neuroscience, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Cell Biol 14:221-9. 2002
    ..Recent studies demonstrate a critical role for the cytoplasmic tails of guidance receptors in signalling and also reveal the potential for a great deal of crosstalk between the various receptor-signalling pathways...
  75. ncbi MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion
    Jonathan R Terman
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 109:887-900. 2002
    ..These results suggest a novel role for oxidoreductases in repulsive neuronal guidance...
  76. ncbi Epithelial fusions in the embryo
    Paul Martin
    Department Anatomy and Developmental Biology, University College London, UK
    Curr Opin Cell Biol 14:569-74. 2002
    ..It is now clear that there are intriguing parallels with more complex morphogenetic tissue movements in vertebrates...
  77. ncbi A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding
    Zachary Wills
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Neuron 36:611-22. 2002
    ..These studies identify Capulet as part of an emerging pathway linking guidance signals to regulation of cytoskeletal dynamics and suggest that the Abl pathway mediates signals downstream of multiple Roundabout receptors...
  78. ncbi Movement through Slits: cellular migration via the Slit family
    Michael Piper
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
    Bioessays 25:32-8. 2003
    ..This review focuses on the non-neuronal activities of Slit proteins, highlighting a common role for the Slit family in cellular migration...
  79. ncbi Axon targeting in the Drosophila visual system
    Timothy D Tayler
    Department of Biology, 68 230 Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Neurobiol 13:90-5. 2003
    ..A role for the visual system glia in orienting photoreceptor axon outgrowth and target selection has also been uncovered...
  80. ncbi Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled
    Patricia J Renfranz
    Department of Biology, Huntsman Cancer Institute, University of Utah, 2000 E Circle of Hope, Salt Lake City, UT 84112 5550, USA
    Gene 305:13-26. 2003
    ..signal, and three proline-rich motifs, one of which matches the consensus for mediating an interaction with Ena/VASP (Drosophila Enabled/Vasodilator-stimulated phosphoprotein) proteins...
  81. ncbi Cascade pathway of filopodia formation downstream of SCAR
    Assel Biyasheva
    Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Sci 117:837-48. 2004
    ..We propose a new, cascade pathway model of filopodia regulation in which SCAR signals to lamellipodia and then filopodia arise from lamellipodia in response to additional signal(s)...
  82. ncbi Nervy links protein kinase a to plexin-mediated semaphorin repulsion
    Jonathan R Terman
    Department of Neuroscience, Johns Hopkins University School of Medicine, 1001 PCTB 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 303:1204-7. 2004
    ..Thus, Nervy couples cAMP-PKA signaling to PlexA to regulate Sema-1a-mediated axonal repulsion, revealing a simple molecular mechanism that allows growing axons to integrate inputs from multiple guidance cues...
  83. ncbi The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion
    Joseph C Ayoob
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:6639-49. 2004
    ..Our results support a model in which cGMP production by Gyc76C facilitates Sema-1a-plexin A-mediated defasciculation of motor axons, allowing for the generation of neuromuscular connectivity in the developing Drosophila embryo...
  84. ncbi Patched regulation of axon guidance is by specifying neural identity in the Drosophila nerve cord
    Tanuja T Merianda
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Genes Evol 215:285-96. 2005
    ..These results provide insight into how mis-specification and loss of neurons can non-autonomously contribute to defects in axon pathfinding...
  85. pmc Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
    Maarten Leyssen
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB and University of Leuven, School of Medicine, Leuven, Belgium
    EMBO J 24:2944-55. 2005
    ..Finally, we also found interactions between APP and the JNK stress kinase cascade. Our findings suggest a role for APP in axonal outgrowth after traumatic brain injury...
  86. ncbi Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle
    Meredith H Price
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Sci 119:403-15. 2006
    ..Finally, we define roles for the canonical Wingless and Hedgehog pathways and for core planar cell polarity proteins in denticle polarity...
  87. ncbi Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling
    Gudrun Wahlström
    Developmental Biology Programme Institute of Biotechnology, Viikki Biocenter, P O Box 56 Viikinkaari 9, FIN 00014, University of Helsinki, Finland
    Mech Dev 123:801-18. 2006
    ..Nevertheless, epithelial morphogenesis proceeded normally. This work provides the first evidence that alpha-actinin is involved in the organisation of the cytoskeleton in a non-muscle tissue in Drosophila...
  88. ncbi Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline
    Long Yang
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Neuron 52:595-607. 2006
    ..These results provide in vivo evidence that the Ras and RhoGEF domains of Sos are separable signaling modules and support a model in which Robo recruits Sos to the membrane via Dock to activate Rac during midline repulsion...
  89. pmc The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila
    Jeong K Song
    Axon Guidance and Neural Connectivity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 37 Room 1016, 37 Convent Drive, Bethesda, MD 20892, USA
    Mech Dev 125:247-56. 2008
    ..We provide evidence that PTP69D modulates signaling by Abl and its antagonist, Ena. An Abl loss-of function mutation dominantly suppresses most Ptp69D mutant phenotypes including larval/pupal ..
  90. pmc Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation
    EDGARDO SANTIAGO-MARTINEZ
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    J Cell Biol 182:241-8. 2008
    ..Our data show that Slit and Robo pathways function in lumen formation as a repulsive signal to antagonize E-Cad-mediated cell adhesion...
  91. pmc A quantitative method to analyze Drosophila pupal eye patterning
    Ruth I Johnson
    Department of Developmental and Regenerative Biology, Mount Sinai Medical School, New York, New York, USA
    PLoS ONE 4:e7008. 2009
    ..Correct rearrangement of cells between ommatidia is required to organize the ommatidial array across the eye field. This requires cell movement, cell death, changes to cell-cell adhesion, signaling and fate specification...
  92. doi Hedgehog, but not Odd skipped, induces segmental grooves in the Drosophila epidermis
    Shai Mulinari
    Department of Experimental Medical Science and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, 22184 Lund, Sweden
    Development 136:3875-80. 2009
    ..Wingless activity is continuously required in the posterior part of parasegments to antagonize segmental groove formation. Our data support an instructive role for the Wingless/Hedgehog organizer in cellular patterning...
  93. doi In vivo coupling of cell elongation and lumen formation in a single cell
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:359-66. 2010
    ..Given the similarities in the formation of fine respiratory tubes and capillaries, we propose that an inward membrane growth model could account for lumen formation in both processes...
  94. doi Regulation of axonal development by the nuclear protein hindsight (pebbled) in the Drosophila visual system
    Carlos Oliva
    Institute of Biomedical Sciences, Universidad de Chile and NEMO, Santiago, Chile
    Dev Biol 344:911-21. 2010
    ..Based on genetic interaction experiments we show that part of HNT function in axonal development is exerted through the regulation of genes involved in the dynamics of the actin cytoskeleton...
  95. pmc JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis
    Melanie Gettings
    Institute of Developmental Biology and Cancer, University of Nice, CNRS, Nice, France
    PLoS Biol 8:e1000390. 2010
    ..Our results reveal plasticity of segment boundaries during late morphogenesis and a role for JNK-dependent developmental reprogramming in this process...
  96. pmc The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
    Wangsun Choi
    Department of Biology, University of North Carolina at Chapel Hill, USA
    Mol Biol Cell 22:2010-30. 2011
    ..meet, closely resemble defects in canoe zygotic null mutants and in embryos lacking the actin regulator Enabled (Ena), suggesting that these proteins act together...
  97. pmc mei-W68 in Drosophila melanogaster encodes a Spo11 homolog: evidence that the mechanism for initiating meiotic recombination is conserved
    K S McKim
    Waksman Institute, Rutgers University, Piscataway, New Jersey 08854 8020, USA
    Genes Dev 12:2932-42. 1998
    ..In contrast to spo11, mei-W68 is not required for synaptonemal complex formation and does have a mitotic role...
  98. pmc Genetic localization of a Drosophila melanogaster resistance gene to a parasitoid wasp and physical mapping of the region
    M T Hita
    Institut de Recherche sur la Biologie de l Insecte, Université F Rabelais, 37200 Tours, France
    Genome Res 9:471-81. 1999
    ..Using single and double digests, cross hybridization of restriction fragments, and location of genetically mapped genes and STSs, a complete, five-enzyme restriction map of this 830-kb region was obtained...
  99. ncbi Axon guidance: A balance of signals sets axons on the right track
    G Gallo
    University of Minnesota, Department of Cell Biology and Neuroanatomy, 4 102 Owre Hall, 435 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Curr Biol 9:R490-2. 1999
    ..Recent studies in vivo have elucidated mechanisms required for this process that involve kinases and phosphatases, calcium dynamics and remodeling of the actin cytoskeleton...
  100. ncbi Adhesion-dependent tyrosine phosphorylation of enabled in Drosophila neuronal cell line
    Y Takagi
    Hirohashi Cell Configuration Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Corporation JST, Japan
    Biochem Biophys Res Commun 270:482-7. 2000
    ..Together with our previous results, we propose a model for signal transduction activated by cell adhesion for the first time in Drosophila...

Research Grants3

  1. Genetic Analysis of Heavy Metals Neurotoxicity
    Fen Biao Gao; Fiscal Year: 2005
    ....
  2. Animal Models For Studying Angelman Syndrome, A Developmental Brain Disorder
    Fen Biao Gao; Fiscal Year: 2008
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page J Description, [unreadable] [unreadable]..
  3. Meiotic spindle formation in Drosophila females
    Kim S McKim; Fiscal Year: 2010
    ..The objective of these studies is to understand how these errors occur. ..