Elav

Summary

Gene Symbol: Elav
Description: embryonic lethal abnormal vision
Alias: 44C11, 9F8A9, CG4262, Dmel\CG4262, EC7, EG:65F1.2, ELAV, ElaV, Elav, Elav-9F8A9, elav-1, elav-2, elav-3, fliJ, l(1)1Be, l(1)EC7, l(1)G0031, l(1)G0319, weg, CG4262-PA, CG4262-PB, CG4262-PC, CG4262-PD, elav-PA, elav-PB, elav-PC, elav-PD, embryonic lethal abnormal visual system, embryonic lethal, abnormal vision, weniger
Species: fruit fly

Top Publications

  1. ncbi Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila
    T L Jacobsen
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington, Indiana, USA
    Development 125:4531-40. 1998
  2. ncbi Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
    J M Warrick
    Department of Biology, University of Pennsylvania and University of Pennsylvania Medical School, Philadelphia 19104, USA
    Cell 93:939-49. 1998
  3. pmc Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells
    Jason Q Boone
    Institute of Neuroscience and Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Dev Neurobiol 68:1185-95. 2008
  4. pmc Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development
    Bruno C Bello
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Neural Dev 3:5. 2008
  5. ncbi Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling
    N M White
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 127:1681-9. 2000
  6. ncbi Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye
    Martin P Kracklauer
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA
    Fly (Austin) 1:75-85. 2007
  7. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
  8. ncbi Notch signalling and the initiation of neural development in the Drosophila eye
    A Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 128:3889-98. 2001
  9. pmc Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium
    Arnold Lee
    Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Mol Biol Cell 15:3285-95. 2004
  10. ncbi Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
    G Halder
    Biozentrum, University of Basel, Switzerland
    Science 267:1788-92. 1995

Research Grants

Detail Information

Publications148 found, 100 shown here

  1. ncbi Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila
    T L Jacobsen
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington, Indiana, USA
    Development 125:4531-40. 1998
    ....
  2. ncbi Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
    J M Warrick
    Department of Biology, University of Pennsylvania and University of Pennsylvania Medical School, Philadelphia 19104, USA
    Cell 93:939-49. 1998
    ..Our results demonstrate that cellular mechanisms of human glutamine-repeat disease are conserved in invertebrates. This fly model will aid in identifying additional factors that modulate neurodegeneration...
  3. pmc Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells
    Jason Q Boone
    Institute of Neuroscience and Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Dev Neurobiol 68:1185-95. 2008
    ..Type II lineages allow more neurons to be produced faster than Type I lineages, which may be advantageous in a rapidly developing organism like Drosophila...
  4. pmc Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development
    Bruno C Bello
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    Neural Dev 3:5. 2008
    ..Here we investigate whether specific neural stem cell-like neuroblasts in the brain of Drosophila might also amplify neuronal proliferation by generating symmetrically dividing intermediate progenitors...
  5. ncbi Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling
    N M White
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 127:1681-9. 2000
    ..Our results strongly suggest that Atonal regulates signalling and other properties of R8 precursors...
  6. ncbi Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye
    Martin P Kracklauer
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA
    Fly (Austin) 1:75-85. 2007
    ..Finally, while perinuclear Klaroid is ubiquitous in the eye, Klarsicht expression is limited to differentiating cells and may be part of the trigger for apical nuclear migration...
  7. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
    ..We have identified a novel mechanism for controlling the balance between self-renewal and neuronal differentiation during the asymmetric division of Drosophila larval NBs...
  8. ncbi Notch signalling and the initiation of neural development in the Drosophila eye
    A Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 128:3889-98. 2001
    ..We also report that Notch drives the transition from pre-proneural to proneural by downregulating two repressors of Atonal: Hairy and Extramacrochaetae...
  9. pmc Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium
    Arnold Lee
    Skirball Institute for Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Mol Biol Cell 15:3285-95. 2004
    ..We suggest that excessive myosin activity in photoreceptor neurons may pull the cell bodies toward the growth cones in a process resembling normal cell migration...
  10. ncbi Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila
    G Halder
    Biozentrum, University of Basel, Switzerland
    Science 267:1788-92. 1995
    ..Because homologous genes are present in vertebrates, ascidians, insects, cephalopods, and nemerteans, ey may function as a master control gene throughout the metazoa...
  11. ncbi Genetic mosaic with dual binary transcriptional systems in Drosophila
    Sen Lin Lai
    Neuroscience Program and Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Nat Neurosci 9:703-9. 2006
    ..In addition, dual-expression-control MARCM with a ubiquitous LexA::GAD driver revealed many unidentified cells in the GAL4-GH146-positive projection neuron lineages...
  12. ncbi Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein
    Z C Lai
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 70:609-20. 1992
    ..Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1...
  13. ncbi Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance
    D M Lin
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Neuron 13:507-23. 1994
    ..These phenotypes show that changes in the pattern and level of Fas II expression can alter growth cone guidance, apparently in part by modulating the ability of these growth cones to respond to other guidance cues...
  14. pmc The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 14:535-46. 2008
    ..Our data describe a transit-amplifying lineage in the Drosophila nervous system and suggest that different vulnerabilities in intermediate cell types can affect the outcome of tumor suppressor loss in stem cell lineages...
  15. ncbi reaper is required for neuroblast apoptosis during Drosophila development
    Christian Peterson
    CBRC, Massachusetts General Hospital Harvard Medical School, Building 149, 13 Street, Charlestown, MA 02129, USA
    Development 129:1467-76. 2002
    ..Although both the ecdysone hormone receptor complex and p53 directly regulate rpr transcription, rpr was found to play a limited role in inducing apoptosis in response to either of these signals...
  16. ncbi Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye
    Lihui Yang
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Cell 4:359-69. 2003
    ..Our results suggest that, rather than triggering all or none responses, EGFR coordinates partially independent processes as the eye differentiates...
  17. ncbi Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 87:651-60. 1996
    ..These results broaden our view of eye development to include the whole ommatidium and suggest that reiterative activation of DER is critical for triggering the differentiation of all cell types...
  18. ncbi Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent
    J Curtiss
    Developmental Biology Programme, EMBL, Meyerhofstrasse 1, Germany
    Development 127:1325-36. 2000
    ..Interestingly, furrow-associated expression of eya, so and dac is not affected by double mutant tissue, suggesting that some other factor(s) regulates their expression during furrow progression...
  19. pmc The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors
    Jean Remy Courbard
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, Annenberg Bldg 18 92, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Biol 333:67-77. 2009
    ..We define a scribble allele that is largely PCP specific. Our data show that Scribble is part of the Stbm/Vang PCP complex and further suggest that it might act as an effector of Stbm/Vang during PCP establishment...
  20. pmc Sine oculis, a member of the SIX family of transcription factors, directs eye formation
    Brandon Weasner
    Department of Biology, Indiana University, 1001 E 3rd Street, Bloomington, IN 47405, USA
    Dev Biol 303:756-71. 2007
    ..Taken together, these results shed new light on the role that so plays in eye specification...
  21. ncbi Adult-like complexity of the larval antennal lobe of D. melanogaster despite markedly low numbers of odorant receptor neurons
    François Python
    Department of Biology and Program in Neuroscience, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Comp Neurol 445:374-87. 2002
    ....
  22. ncbi Morphogenesis and proliferation of the larval brain glia in Drosophila
    Wayne Pereanu
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, CA 90095, USA
    Dev Biol 283:191-203. 2005
    ..This increase results from mitosis of differentiated glia, but, more significantly, from the proliferation of neuroblasts...
  23. ncbi Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Dev Cell 10:441-9. 2006
    ..Single neuroblast clones lacking Prospero have a similar phenotype. We conclude that Brat suppresses neuroblast stem cell self-renewal and promotes neuronal differentiation...
  24. ncbi The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila
    Bruno Bello
    Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 133:2639-48. 2006
    ....
  25. ncbi Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development
    S Robinow
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    J Neurobiol 22:443-61. 1991
    The embryonic lethal abnormal visual system (elav) gene of Drosophila melanogaster is required for the development and maintenance of the nervous system...
  26. ncbi Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Development 126:2083-92. 1999
    ..Pros misexpression is sufficient for the transformation of PIIa to PIIb fate. The expression of Pros in the normal PIIb cell appears to be regulated by Notch signaling...
  27. ncbi PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism
    A H Tang
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Cell 90:459-67. 1997
    ....
  28. ncbi Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack
    S Li
    Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260, USA
    Cell 90:469-78. 1997
    ..These results argue that photoreceptor differentiation is regulated by the RAS pathway through targeted proteolysis of the TTK repressor...
  29. pmc A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling
    J D Wasserman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Genes Dev 14:1651-63. 2000
    ..Rhomboid-1 and Roughoid/Rhomboid-3 act in the signal-emitting not signal-receiving cell, supporting the idea that Spitz activation is regulated by Rhomboid-like molecules...
  30. ncbi split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells
    F Chen
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Curr Biol 10:943-6. 2000
    ..Therefore, spen encodes a positively acting component of the DER/Ras signaling pathway...
  31. doi AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster
    Satoshi Kametaka
    Department of Anatomy and Histology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima 960 1295, Japan
    J Cell Sci 125:634-48. 2012
    ..These results suggest that AP-1 and Aftiphilin are cooperatively involved in the intracellular trafficking of Notch during eye development in Drosophila...
  32. ncbi Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes
    N H Patel
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Methods Cell Biol 44:445-87. 1994
  33. ncbi Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila
    R Chen
    Departments of Pathology, Molecular and Human Genetics and Ophthalmology, and Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 126:935-43. 1999
    ..These results suggest a mechanism by which a general patterning signal such as Decapentaplegic cooperates reiteratively with tissue-specific factors to determine distinct cell fates during development...
  34. pmc Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
    Maarten Leyssen
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB and University of Leuven, School of Medicine, Leuven, Belgium
    EMBO J 24:2944-55. 2005
    ..Finally, we also found interactions between APP and the JNK stress kinase cascade. Our findings suggest a role for APP in axonal outgrowth after traumatic brain injury...
  35. doi AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors
    Najate Benhra
    CNRS UMR 6061 Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 2 avenue du Professeur Bernard, 35000 Rennes, France
    Curr Biol 21:87-95. 2011
    ..Because AP-1 does not prevent endocytosis and recycling of the Notch ligand Delta, our data indicate that the DE-cadherin junctional domain may act as a launching pad through which endocytosed Notch ligand is trafficked for signaling...
  36. ncbi Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells
    Erin Overstreet
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Moffett Molecular Biology Building, 2500 Speedway, Austin, TX 78712, USA
    Development 131:5355-66. 2004
    ..We propose that Faf plays a role similar to that of Neur in the Delta signaling cells. By deubiquitinating Lqf, which enhances the efficiency of Delta internalization, Faf stimulates Delta signaling...
  37. pmc FlyPNS, a database of the Drosophila embryonic and larval peripheral nervous system
    Virginie Orgogozo
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    BMC Dev Biol 5:4. 2005
    ..One main advantage of this system is the ability to study the origin and development of individual sensory cells. However, there remain several discrepancies regarding the organization of sensory organs in each abdominal segment A1-A7...
  38. doi The tumor suppressor, vitamin D3 up-regulated protein 1 (VDUP1), functions downstream of REPO during Drosophila gliogenesis
    Neil V Mandalaywala
    Department of Pharmaceutical Sciences, Albany College of Pharmacy, O Brien Building, Room 017C, 106 New Scotland Ave, Albany, NY 12208, USA
    Dev Biol 315:489-504. 2008
    ..Subsequent to expression of the neuronal marker elav, dVDUP1 is up-regulated to varying degrees in developing neurons...
  39. ncbi HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis
    L Zhou
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Mol Cell 4:745-55. 1999
    ..Our data indicate that caspase activation and apoptosis in Drosophila are independently controlled by at least two distinct regulatory pathways that converge at the level of caspase activation...
  40. ncbi Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina
    L Yang
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 128:1183-91. 2001
    ..The results prove that R8 photoreceptors are specified and positioned by distinct mechanisms from photoreceptors R1-R7...
  41. pmc Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models
    Takuya Tamura
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 4:e4262. 2009
    ..However the generality of the non-cell autonomous pathologies derived from glial cells has not been established, and the specificity among different neurodegenerative disorders remains unknown...
  42. ncbi Spatial, temporal, and sexually dimorphic expression patterns of the fruitless gene in the Drosophila central nervous system
    G Lee
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurobiol 43:404-26. 2000
    ..Expression of sex-specific fru mRNAs in the CNS of males analyzed from the earliest pupal stages indicated that sex-specific alternative splicing is not the exclusive mechanism regulating expression of fruitless transcripts...
  43. ncbi Myosin II regulates complex cellular arrangement and epithelial architecture in Drosophila
    Luis M Escudero
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Dev Cell 13:717-29. 2007
    ..Our work implies that regulation of the actomyosin cytoskeleton can control morphogenesis by regulating both individual cell shapes and their complex two-dimensional arrangement within epithelia...
  44. ncbi An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling
    Leo Tsuda
    Department of Biological Chemistry and Department of Human Genetics, Molecular Biology Institute, Los Angeles, CA 90095, USA
    Cell 110:625-37. 2002
    ..EGFR-activated transcriptional derepression requires ebi and sno, is proteasome-dependent, and correlates with the translocation of SMRTER to the cytoplasm...
  45. pmc The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye
    Kristin Patterson
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA
    Mol Biol Cell 15:600-10. 2004
    ..The Klarsicht/lamin interaction provides a framework for understanding the mechanistic basis of human laminopathies...
  46. ncbi Cell cycle progression in the developing Drosophila eye: roughex encodes a novel protein required for the establishment of G1
    B J Thomas
    Department of Biological Chemistry, University of California, Los Angeles 90024
    Cell 77:1003-14. 1994
    ..e., Ras1 and Star). rux encodes a novel protein of 335 amino acids. We propose that rux functions as a negative regulator of G1 progression in the developing eye...
  47. ncbi glial cells missing and gcm2 cell autonomously regulate both glial and neuronal development in the visual system of Drosophila
    Carole Chotard
    Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    Neuron 48:237-51. 2005
    ..Our findings further suggest that gcm genes regulate neurogenesis through collaboration with the Hedgehog-signaling pathway...
  48. ncbi Regulation of R7 and R8 differentiation by the spalt genes
    Pedro M Domingos
    Howard Hughes Medical Institute, Strang Laboratory of Cancer Research, The Rockefeller University, New York, NY 10021, USA
    Dev Biol 273:121-33. 2004
    ..Taken together, our results suggest that while spalt is required for R7 differentiation during larval stages, spalt and senseless promote terminal R8 differentiation during pupal stages, including the regulation of rhodopsin expression...
  49. ncbi Cooperative activities of drosophila DE-cadherin and DN-cadherin regulate the cell motility process of ommatidial rotation
    Ivana Mirkovic
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY, USA
    Development 133:3283-93. 2006
    ..A similar input into mammalian E- and N-cadherins might function in the progression of diseases such as metastatic ovarian cancer...
  50. ncbi The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
    Eric C Lai
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 132:2319-32. 2005
    ..We conclude that ubiquitination of Delta and Serrate by Neuralized and D-mib is an obligate feature of DSL ligand activation throughout Drosophila development...
  51. ncbi Ectopic eye development in Drosophila induced by directed dachshund expression
    W Shen
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 124:45-52. 1997
    ..These results suggest that the control of eye development requires the complex interaction of multiple genes, even at the very highest regulatory levels...
  52. ncbi A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye
    Xin Li
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
    Cell 123:1267-77. 2005
    ..Expression is switched when EGFR signaling transiently triggers Yan degradation. This two-tiered mechanism explains how signal transduction activity can robustly generate a stable change in gene-expression patterns...
  53. pmc The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death
    Kathryn Mills
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, Australia 5000
    J Cell Biol 172:809-15. 2006
    ..During metamorphosis, larval salivary gland removal was severely delayed in ark mutants. However, PCD occurred normally in the larval midgut, suggesting that ARK-independent cell death pathways also exist in D. melanogaster...
  54. pmc scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
    Anthony M Brumby
    Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    EMBO J 22:5769-79. 2003
    ....
  55. ncbi Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation
    J P Kumar
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322 3030, USA
    Development 125:3875-85. 1998
    ..Similarly, SEVENLESS-dependent activation results in cytoplasmic appearance of dp-ERK for 6 hours. These results suggest an additional regulated step in this pathway and we discuss models for this...
  56. ncbi Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina
    F Chanut
    Department of Neurology, University of California San Francisco, 94110, USA
    Development 124:559-67. 1997
    ..Finally, we show that in the later stages of retinal differentiation, reduction of dpp function leads to an arrest in MF progression...
  57. ncbi Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage
    L Manning
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana, IL 61801, USA
    Development 126:2063-71. 1999
    ..Finally, in contrast to previous studies, we find that the IIb cell divides prior to the IIa cell in the SOP lineage...
  58. ncbi Uncoupling cell fate determination from patterned cell division in the Drosophila eye
    J C de Nooij
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Science 270:983-5. 1995
    ..However, the second mitotic wave is needed to generate appropriate numbers of each cell type. Moreover, p21 can arrest precursor cell proliferation and allow appropriate fate choice in vivo...
  59. doi Determination of cell fates in the R7 equivalence group of the Drosophila eye by the concerted regulation of D-Pax2 and TTK88
    Yandong Shi
    Institute for Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Dev Biol 331:68-77. 2009
    ..Thus, the fates of R1/R6/R7 and cone cells are determined by a dual mechanism that coordinately activates one fate while inhibiting the other...
  60. pmc A screen for modifiers of cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2
    M E Lane
    Department of Genetics, University of Bayreuth, 95440 Bayreuth, Germany
    Genetics 155:233-44. 2000
    ..In contrast, our results demonstrate that the equivalent sites in Cdk2 play no essential role...
  61. ncbi Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye
    Katherine E Brown
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 130:5401-12. 2003
    ....
  62. pmc Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases
    Shaul Yogev
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    EMBO J 27:1219-30. 2008
    ..These observations identify changes in intracellular compartment localization of Rho proteins as a basis for signal attenuation, in tissues where EGFR activation must be highly restricted in space and time...
  63. ncbi Glia maintain follower neuron survival during Drosophila CNS development
    G E Booth
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, Cambridge, UK
    Development 127:237-44. 2000
    ..This differential requirement of neurons for glia is instructive in patterning and links control of cell number with axon guidance during CNS development...
  64. ncbi The glial cell undergoes apoptosis in the microchaete lineage of Drosophila
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Development 130:123-33. 2003
    ..Finally, we present evidences showing that glial cells are committed to apoptosis independently of gcm and prospero expression. We suggest that apoptosis is triggered by a cell autonomous mechanism...
  65. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
    ..Our data indicate that Sec15 mediates a specific vesicle trafficking event to ensure proper neuronal fate specification in Drosophila...
  66. pmc The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila
    Ho Juhn Song
    Department of Zoology, Oregon State University, Corvallis, Oregon 97331 2914, USA
    Genetics 162:1703-24. 2002
    ..Our results suggest that one of fru's sex-nonspecific roles is to regulate the pathfinding ability of axons in the embryonic CNS...
  67. pmc ELAV multimerizes on conserved AU4-6 motifs important for ewg splicing regulation
    Matthias Soller
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Mol Cell Biol 25:7580-91. 2005
    b>ELAV is a gene-specific regulator of alternative pre-mRNA processing in Drosophila neurons...
  68. pmc Shared RNA-binding sites for interacting members of the Drosophila ELAV family of neuronal proteins
    Claudia D Borgeson
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 4525, USA
    Nucleic Acids Res 33:6372-83. 2005
    The product of the Drosophila embryonic lethal abnormal visual system is a conserved protein (ELAV) necessary for normal neuronal differentiation and maintenance...
  69. ncbi Mechanism of hedgehog signaling during Drosophila eye development
    Kartik S Pappu
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 130:3053-62. 2003
    ..Moreover, while the effects of Hh are primarily concentration dependent in other tissues, hh signaling in the eye acts as a binary switch to initiate retinal morphogenesis by inducing expression of the tissue-specific factor Eya...
  70. pmc Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila
    Max Mühlig-Versen
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Sciences University, Portland, Oregon 97239, USA
    J Neurosci 25:2865-73. 2005
    ..We conclude that SWS is essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult Drosophila brain and that NTE may play an analogous role in vertebrates...
  71. ncbi Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage
    Pierre Fichelson
    UMR 7622, CNRS Universite Paris VI, 9, quai St Bernard, 75252 Paris Cedex 05, France
    Dev Biol 276:367-77. 2004
    ..These transformations in cell identity suggest that, although synchronized, cell cycle and fate determination are independent phenomena in the bristle lineage...
  72. pmc Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex
    Yue Hu
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Cell Biol 161:685-90. 2003
    ..These results demonstrate that Aph-1 and Pen-2 are essential cofactors for Psn, but that they play different roles in gamma-secretase assembly and activation...
  73. ncbi A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila
    Stefan Koelzer
    Institute für Genetik, Universitaet zu Koeln, Weyertal 121, 50931 Koeln, Germany
    Development 130:1973-88. 2003
    ..Our results further suggest that the position of the SOP in a proneural cluster is determined by very precise positional cues, which render the SOP insensitive to Dl...
  74. pmc Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye
    Justin P Kumar
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 130:3703-14. 2003
    ..This "cytoplasmic hold" of activated MAPK has not been observed in cell culture systems. We also show that MAPK cytoplasmic hold has an essential function in vivo: if it is overcome, developmental patterning in the furrow is disrupted...
  75. ncbi Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo
    Jennifer Bayraktar
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
    J Cell Sci 119:711-21. 2006
    ..Epistasis analysis indicates that Par-1 functions upstream of Notch and is critical for proper localization of the Notch ligand Delta...
  76. ncbi Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 133:1683-92. 2006
    ..Our data indicate that transcription factors other than bHLH proteins can also perform the proneural function in the Drosophila peripheral nervous system...
  77. pmc Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes
    Orie Thomas Shafer
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 498:180-93. 2006
    ..Finally, we present molecular and anatomical evidence for unrecognized phenotypic diversity within each of four established classes of clock neurons...
  78. ncbi Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway
    Katherine E Brown
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Dev Biol 300:710-21. 2006
    ..These observations define a new function for EGFR signalling in eye development and illustrate a mechanism for the control of epithelial morphology by developmental signals...
  79. ncbi Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye
    M T Cooper
    Department of Anatomy, University of Cambridge, UK
    Nature 397:526-30. 1999
    ....
  80. pmc Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila
    Swati Banerjee
    Department of Cell and Molecular Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Dev Biol 317:585-99. 2008
    ..Our studies may provide clues towards understanding the vertebrate BEB formation and function...
  81. ncbi decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc
    D J Hazelett
    Skirball Institute for Biomolecular Medicine and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA
    Development 125:3741-51. 1998
    ..These results provide a link between the early specification and later differentiation of the eye disc...
  82. ncbi The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein
    C A Dye
    Department of Cell Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Development 125:1845-56. 1998
    ..Loss of sanpodo leads to an aberrant F-actin distribution and causes differentiation defects of actin-containing sensory structures. Our data suggest that an actin-based process is involved in Notch signaling...
  83. ncbi Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms
    J Ewer
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    J Neurosci 12:3321-49. 1992
    ..of a reporter of per expression, in conjunction with an antibody to the embryonic lethal-abnormal visual system (elav) gene product--which is used as a marker of neuronal identity--we have experimentally confirmed previously proposed ..
  84. ncbi Induction of Drosophila eye development by decapentaplegic
    F Pignoni
    Howard Hughes Medical Institute, The School of Medicine, University of California, Los Angeles 90095, USA
    Development 124:271-8. 1997
    ..In addition, Dpp positively controls its own expression and suppresses wingless transcription. In contrast to the wing disc, Dpp does not appear to be the principal mediator of Hedgehog function in the eye...
  85. ncbi Proneural function of neurogenic genes in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Biol 7:122-32. 1997
    ..On this basis, complete elimination of Notch gene function would be expected to cause neural hyperplasia in the eye...
  86. ncbi ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform
    S P Koushika
    Biology Department, Brandeis University, Waltham, Massachusetts 02254, USA
    Curr Biol 6:1634-41. 1996
    ..In Drosophila melanogaster, the RNA-binding protein encoded by the elav (embryonic lethal abnormal visual system) gene is a candidate for such a role...
  87. pmc Requirement for a core 1 galactosyltransferase in the Drosophila nervous system
    Yuh Ru Lin
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Dev Dyn 237:3703-14. 2008
    ..Lectin staining and blotting experiments confirmed that C1GalTA contributes to the synthesis of Gal-beta1,3-GalNAc in vivo. Our results identify a role for mucin-type O-glycosylation during neural development in Drosophila...
  88. ncbi wingless inhibits morphogenetic furrow movement in the Drosophila eye disc
    J E Treisman
    Department of Molecular and Cell Biology, UC Berkeley 94720, USA
    Development 121:3519-27. 1995
    ..In addition, the presence of wingless in the center of the disc can prevent furrow progression. These effects of wingless are achieved without altering the expression of decapentaplegic...
  89. ncbi Ectopic expression of seven-up causes cell fate changes during ommatidial assembly
    Y Hiromi
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Development 118:1123-35. 1993
    ..Our results also suggest that seven-up controls decisions not only between photoreceptor subtypes, but also between neuronal and non-neuronal fates...
  90. ncbi Mutant alleles at the locus elav in Drosophila melanogaster lead to nervous system defects. A developmental-genetic analysis
    A R Campos
    J Neurogenet 2:197-218. 1985
    ..The embryonic lethality caused by the mutant alleles and abnormalities observed in the genetic mosaics have led us to rename the locus l(1)EC7 to elav (embryonic lethal, abnormal visual system).
  91. ncbi Identification and characterization of a neuron-specific nuclear antigen in Drosophila
    E Bier
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Science 240:913-6. 1988
    ..Protein immunoblot analyses and immune precipitation experiments show that the neuronal nuclear antigen is a 50-kilodalton polypeptide...
  92. ncbi A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase
    U Gaul
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 68:1007-19. 1992
    ..Our results suggest that Gap1 acts as a negative regulator of signaling by Sevenless by down-regulating the activity of the Ras1 protein, which has been shown to be a key element in signaling by Sevenless...
  93. ncbi Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
    Y Ye
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 398:525-9. 1999
    ..They also link the role of presenilin in Notch signalling to its effect on amyloid production in Alzheimer's disease...
  94. doi Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch
    Adam C Miller
    Institute of Molecular Biology, University of Oregon, 1370 Franklin Blvd, Eugene, OR 97403, USA
    Development 135:707-15. 2008
    ..We show that N specifies the R7 fate by a novel branched pathway: N represses Svp expression, thereby exposing an underlying stochastic choice between the R7 and R8 fates, and then tips this choice towards the R7 fate...
  95. ncbi Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor
    Yue Hu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 2:69-78. 2002
    ..Nicastrin might recruit gamma-secretase substrates into the proteolytic complex as a prerequisite for Presenilin maturation and active complex assembly...
  96. ncbi Redundant function of Runt Domain binding partners, Big brother and Brother, during Drosophila development
    J S Kaminker
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Development 128:2639-48. 2001
    ..These studies highlight a mechanism for transcriptional control by a Runt Domain protein and a redundant pair of partners in the specification of cell fate during development...
  97. ncbi The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila
    Ciara M Gallagher
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 11:641-53. 2006
    ..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs...
  98. ncbi Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye
    Y Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Biol 11:330-8. 2001
    ..During Drosophila eye development, Notch plays an additional role in promoting neural fate independently of Su(H) and E(spl)-C, and this finding suggests an alternative mechanism of Notch signal transduction...
  99. ncbi The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 104:699-708. 2001
    ..Through proliferation and survival control, such signals couple the total number of uncommitted cells being generated to the neural patterning of the retina...
  100. ncbi Novel gcm-dependent lineages in the postembryonic nervous system of Drosophila melanogaster
    Laurent Soustelle
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Strasbourg, France
    Dev Dyn 236:2101-8. 2007
    ..It is also expressed in a thoracic glial lineage and in neurons of the ventral nerve cord (VNC). Finally, while gcm is required for gliogenesis in medulla and VNC, it does not seem to be required for the generation of VNC neurons...
  101. pmc The neuron-enriched splicing pattern of Drosophila erect wing is dependent on the presence of ELAV protein
    S P Koushika
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Mol Cell Biol 20:1836-45. 2000
    ..In this paper, we show that ELAV, a neuron-specific RNA binding protein, is necessary to regulate EWG protein expression in ELAV-null eye imaginal ..

Research Grants11

  1. Molecular Genetics of Polyglutamine-Induced Degeneration
    George Jackson; Fiscal Year: 2003
    ..abstract not available ..
  2. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  3. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas E Baker; Fiscal Year: 2010
    ....
  4. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
  5. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  6. Exploring TSLP as a Key Initiator and Novel Therapeutic Target for Asthma
    Baohua Zhou; Fiscal Year: 2008
    ..Our goal is to elucidate the roles of thymic stromal lymphopoietin (TSLP) in the pathogenesis of asthma and explore TSLP as a novel therapeutic target to prevent and/or control the disease. [unreadable] [unreadable] [unreadable]..
  7. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  9. Eye Development: Molecular Genetics of Nuclear Migration
    Janice Fischer; Fiscal Year: 2005
    ..Finally, a variety of different genetic screening approaches will be used to identify additional genes in the klarsicht/egk1 pathway. ..
  10. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....