Egfr

Summary

Gene Symbol: Egfr
Description: Epidermal growth factor receptor
Alias: C-erb, CG10079, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/top, DER/torpedo, DER1, DEgfr, Degfr, Der, DmHD-33, Dmel\CG10079, EC2-4, EFG-R, EGF-R, EGFR, EGFr, EGfr, EK2-6, Egf, Egf-r, EgfR, Elp, Elp-1, Elp-B1, Elp-B1RB1, Flb, HD-33, TOP, Tor, Torpedo/DER, Torpedo/Egfr, c-erbB, d-egf-r, dEGFR, dEGFR1, dEGFr, dEgfr, degfr, der, egfr, flb, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57EFa, l(2)57Ea, mor1, top, top/DER, top/flb, torpedo/Egfr, torpedo/egfr, CG10079 gene product from transcript CG10079-RA, CG10079-PA, CG10079-PB, DER-Ellipse, EGF-receptor, EGFR, Egf receptor, Egfr-PA, Egfr-PB, dEGFR, drosophila epidermal growth factor receptor homologue, ellipse, ellipse torpedo, epidermal growth factor receptor, faint little ball, morphological defects 1, torpedo, torpedo/DER
Species: fruit fly

Top Publications

  1. ncbi The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 104:699-708. 2001
  2. ncbi Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling
    Andreas Bergmann
    Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 2:159-70. 2002
  3. ncbi Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye
    Katherine E Brown
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 130:5401-12. 2003
  4. ncbi Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors
    A P Jarman
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Development 121:2019-30. 1995
  5. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
  6. ncbi Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila
    N Perrimon
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115
    Curr Opin Cell Biol 6:260-6. 1994
  7. ncbi An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg
    J D Wasserman
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 95:355-64. 1998
  8. ncbi Somatic support cells restrict germline stem cell self-renewal and promote differentiation
    A A Kiger
    Department of Developmental Biology, Stanford University School of Medicine, California 94305 5329, USA
    Nature 407:750-4. 2000
  9. ncbi Polarization of both major body axes in Drosophila by gurken-torpedo signalling
    A González-Reyes
    Wellcome CRC Institute, University of Cambridge, UK
    Nature 375:654-8. 1995
  10. ncbi Analysis of genetic mosaics in developing and adult Drosophila tissues
    T Xu
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Development 117:1223-37. 1993

Research Grants

  1. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
  2. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
  3. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
  4. Genome wide analysis and modeling of signal integration in the Drosophila ovary
    Stanislav Shvartsman; Fiscal Year: 2009
  5. MSM: CR Multiscale analysis of epithelial patterning: m*
    Stanislav Shvartsman; Fiscal Year: 2007
  6. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
  7. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
  8. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
  9. Development of tissue-specific cell lines in Drosophila
    Amanda Simcox; Fiscal Year: 2009
  10. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas E Baker; Fiscal Year: 2010

Detail Information

Publications181 found, 100 shown here

  1. ncbi The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 104:699-708. 2001
    ..We find that G1/S progression to start the cell cycle requires EGF receptor inactivity...
  2. ncbi Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling
    Andreas Bergmann
    Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 2:159-70. 2002
    ..of midline glia cells in Drosophila depends upon direct suppression of the proapoptotic protein HID via the EGF receptor/RAS/MAPK pathway...
  3. ncbi Egfr signalling defines a protective function for ommatidial orientation in the Drosophila eye
    Katherine E Brown
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 130:5401-12. 2003
    ..Here, we demonstrate a requirement for epidermal growth factor receptor (Egfr) signalling in rotation, further adding to the manifold actions of this pathway in eye ..
  4. ncbi Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors
    A P Jarman
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Development 121:2019-30. 1995
    ..Nevertheless, a remnant morphogenetic furrow is still observed in the atonal mutant disc. This presumably reflects the process of furrow initiation, which would not depend on signals from developing photoreceptors...
  5. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  6. ncbi Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila
    N Perrimon
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115
    Curr Opin Cell Biol 6:260-6. 1994
    ..e. Grb2, Sos, Ras-Gap, p21ras, Raf, MEK and MAPK, genetic studies have suggested that two novel proteins, the protein tyrosine phosphatase (PTPase) Csw and the transmembrane protein Rho, are involved in RPTK signalling...
  7. ncbi An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg
    J D Wasserman
    MRC Laboratory of Molecular Biology, Cambridge, England
    Cell 95:355-64. 1998
    Intercellular signaling through the EGF receptor (EGFR) patterns the Drosophila egg. The TGF alpha-like ligand Gurken signals from the oocyte to the receptor in the overlying somatic follicle cells...
  8. ncbi Somatic support cells restrict germline stem cell self-renewal and promote differentiation
    A A Kiger
    Department of Developmental Biology, Stanford University School of Medicine, California 94305 5329, USA
    Nature 407:750-4. 2000
    ..Loss of function of the Drosophila Epidermal growth factor receptor in somatic cells disrupted the balance of self-renewal versus differentiation in the male germline, ..
  9. ncbi Polarization of both major body axes in Drosophila by gurken-torpedo signalling
    A González-Reyes
    Wellcome CRC Institute, University of Cambridge, UK
    Nature 375:654-8. 1995
    ..We demonstrate that gurken is necessary in the oocyte and torpedo/DER in the follicle cells for the induction of posterior fate...
  10. ncbi Analysis of genetic mosaics in developing and adult Drosophila tissues
    T Xu
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Development 117:1223-37. 1993
    ..these strains can be used to study a particular gene, we have analyzed the developmental role of the Drosophila EGF receptor homolog...
  11. ncbi A thousand and one roles for the Drosophila EGF receptor
    R Schweitzer
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Trends Genet 13:191-6. 1997
    ..during development, as reflected by the many designations given to mutant alleles in the locus (Egfr, DER, faint little ball, torpedo and Ellipse)...
  12. ncbi Cell determination strategies in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Development 124:261-70. 1997
    ..This model arises from the recent observation that the Drosophila homologue of the EGF receptor (DER) is used reiteratively to trigger the differentiation of each of the cell types--successive rounds of DER ..
  13. ncbi Activation of knot (kn) specifies the 3-4 intervein region in the Drosophila wing
    J Mohler
    Department of Biological Sciences, Barnard College, New York, NY 10027, USA
    Development 127:55-63. 2000
    ..Expression of the gene encoding the EGF-receptor (EGFR), which is required for vein initiation and subsequent differentiation, is normally depressed in the 3-4 intervein ..
  14. pmc Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites
    L Ciapponi
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Genes Dev 15:1540-53. 2001
    ..biological effects of JNK activation, whereas mutations in ERK phosphorylation sites affect responses to the EGF receptor-Ras-ERK pathway...
  15. ncbi Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Curr Biol 13:1888-93. 2003
    ..A survey of association between 267 SNPs in almost 11 kb of the D. melanogaster Egfr and the degree of eye roughening due to a gain-of-function Egfr(E1) allele crossed into 210 isogenic wild-type ..
  16. ncbi Drosophila-based in vivo assay for the validation of inhibitors of the epidermal growth factor receptor/Ras pathway
    Anuradha Aritakula
    Division of Biological Sciences, Vittal Mallya Scientific Research Foundation, K R Road, P O Box 406, Bangalore 560 004, India
    J Biosci 33:731-42. 2008
    Overexpression of epidermal growth factor receptor (EGFR) is a common phenomenon observed in most cancers...
  17. ncbi Quantitative developmental genetic analysis reveals that the ancestral dipteran wing vein prepattern is conserved in Drosophila melanogaster
    A Palsson
    Department of Genetics, North Carolina State University, Raleigh, NC 27695 7614, USA
    Dev Genes Evol 210:617-22. 2000
    ..to be involved in wing patterning in Drosophila melanogaster suggests that the genes decapentaplegic, thickveins, EGFR, argos and hedgehog, each of which are involved in secreted growth factor signaling, may contribute to wing shape ..
  18. ncbi Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye
    Lihui Yang
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Cell 4:359-69. 2003
    Receptor tyrosine kinases such as the EGF receptor transduce extracellular signals into multiple cellular responses. In the developing Drosophila eye, EGFR activity triggers cell differentiation...
  19. pmc Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene
    R J Clifford
    Biology Department, Princeton University, New Jersey 08544 1003
    Genetics 123:771-87. 1989
    The torpedo (top) locus of Drosophila encodes the fruitfly homolog of the vertebrate epidermal growth factor receptor gene and the neu proto-oncogene...
  20. ncbi Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 87:651-60. 1996
    ..I have used a dominant-negative form of the Drosophila epidermal growth factor receptor (DER) to show that this receptor tyrosine kinase (RTK) is required for the differentiation of all ..
  21. ncbi Antagonistic roles of Rac and Rho in organizing the germ cell microenvironment
    Angshuman Sarkar
    Department of Molecular Biology and Microbiology, Case Western Reserve, University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Curr Biol 17:1253-8. 2007
    ..This physical interrelationship depends on signaling from germ cells to the Epidermal growth factor receptor (Egfr) on somatic support cells [4]...
  22. pmc Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts
    Nikolay Ninov
    Instituto de Biologia Molecular de Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona, Spain
    PLoS Biol 7:e1000079. 2009
    ..histoblasts proceed to a stage of slower proliferation that, in contrast to the preceding, depends on epidermal growth factor receptor (EGFR) signaling for progression through the G2/M transition and on insulin receptor/PI3K-mediated ..
  23. ncbi Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain
    Begona De Velasco
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Biol 302:309-23. 2007
    ..The other early activated signaling pathway, EGFR, is positively required for the maintenance of the PI placode...
  24. pmc Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development
    Vincent Dammai
    Department of Pathology and Laboratory Medicine, and Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Genes Dev 17:2812-24. 2003
    ..Thus, we propose that awd regulates tracheal cell motility by modulating the FGFR levels, through a dynamin-mediated pathway...
  25. pmc Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing
    David D O'Keefe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 311:25-39. 2007
    b>Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila wing...
  26. ncbi Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor
    N E Baker
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Nature 340:150-3. 1989
    ..We present genetic evidence that Elp alleles are mutations of the Drosophila homologue of the epidermal growth factor (EGF) receptor, and suggest that activity of the EGF receptor may determine the spacing pattern of ommatidia in the eye.
  27. pmc A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling
    J D Wasserman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Genes Dev 14:1651-63. 2000
    As in mammals, the Drosophila EGF receptor controls many aspects of growth and development...
  28. ncbi The PDGF/VEGF receptor controls blood cell survival in Drosophila
    Katja Brückner
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Dev Cell 7:73-84. 2004
    ..This function of PVR shows striking conservation with mammalian hematopoiesis and establishes Drosophila as a model to study hematopoietic cell survival in development and disease...
  29. pmc Control of Distal-less expression in the Drosophila appendages by functional 3' enhancers
    Maximo Ibo Galindo
    Instituto de Biomedicina de Valencia IBV CSIC, Jaime Roig, 11, 46010 Valencia, Spain
    Dev Biol 353:396-410. 2011
    ..In addition, our results suggest that some enhancers, contrary to the widely accepted notion, may require a specific 5' or 3' position with respect to the transcribed region...
  30. ncbi The role of yan in mediating the choice between cell division and differentiation
    R Rogge
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles 90095, USA
    Development 121:3947-58. 1995
    An allele of the yan locus was isolated as an enhancer of the Ellipse mutation of the Drosophila epidermal growth factor receptor (Egfr) gene...
  31. ncbi Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina
    L Yang
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 128:1183-91. 2001
    The Drosophila EGF receptor is required for differentiation of many cell types during eye development...
  32. ncbi Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:629-39. 1994
    ..We show that Raf functions downstream of the EGF receptor to instruct the dorsal follicle cell fate...
  33. ncbi Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins
    B Schnepp
    Department of Molecular Genetics, The Ohio State University, Columbus 43210, USA
    Genes Dev 10:2302-13. 1996
    The activation signal from tyrosine kinase receptors, such as the epidermal growth factor receptor (EGFR), is relayed via a highly conserved intracellular pathway involving Ras, Raf, and MAPK...
  34. ncbi Ras promotes cell survival in Drosophila by downregulating hid expression
    P Kurada
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Cell 95:319-29. 1998
    ..Genetic evidence indicates that Ras antiapoptotic activity in the developing eye is regulated by the Drosophila EGF receptor and operates through the Raf/MAPK pathway...
  35. ncbi Guidance of cell migration by EGF receptor signaling during Drosophila oogenesis
    P Duchek
    Developmental Biology Programme, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Science 291:131-3. 2001
    ..Here we present evidence that signaling mediated by the epidermal growth factor receptor (EGFR) guides dorsal migration of border cells during Drosophila oogenesis...
  36. ncbi Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye
    Lucy C Firth
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Dev Cell 8:541-51. 2005
    ..Cell cycle entry is induced by Notch signaling and opposed in subsets of cells by EGF receptor activity. Unusually, Cyclin E levels are not limiting for retinal cell cycles...
  37. ncbi A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye
    Xin Li
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
    Cell 123:1267-77. 2005
    ..This is dependent on EGF receptor (EGFR) signaling that triggers ERK-mediated degradation of the transcription factor Yan...
  38. pmc EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors
    Huaqi Jiang
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Development 136:483-93. 2009
    ..We find that signaling through the EGFR/RAS/MAPK pathway is necessary and limiting for AMP proliferation...
  39. ncbi The EGF and FGF receptors mediate neuroglian function to control growth cone decisions during sensory axon guidance in Drosophila
    L Garcia-Alonso
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas, Universidad Miguel Hernandez, 03550, San Juan de Alicante, Spain
    Neuron 28:741-52. 2000
    ..loss-of-function conditions of either the Neuroglian CAM, the FGF receptor coded by the gene heartless, or the EGF receptor coded by DER display a similar phenotype of abnormal substrate selection and axon guidance by peripheral ..
  40. ncbi Localization of the DER/flb protein in embryos: implications on the faint little ball lethal phenotype
    N B Zak
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Development 109:865-74. 1990
    ..We have thus observed that DER is expressed in the diverse tissues which are affected in the DER faint little ball (flb) embryonic lethal phenotype...
  41. ncbi Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors
    P zur Lage
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 126:3149-57. 1999
    ..This is achieved by a novel interplay of inductive epidermal growth factor-receptor (EGFR) and competitive Notch signals...
  42. ncbi Sequence and functional properties of Ets genes in the model organism Drosophila
    T Hsu
    Center for Molecular and Structural Biology, Hollings Cancer Center, and Department of Cell Biology and Anatomy, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, South Carolina, SC 29425, USA
    Oncogene 19:6409-16. 2000
    ..The information should be of significant value to the study of related processes in higher organisms due to the growing evidence for the cross species conservation of developmental mechanisms...
  43. ncbi Signal transduction. Are there close encounters between signaling pathways?
    S Noselli
    Institut de Recherches, UMR 65643 CNRS, Parc Valrose 06108, Nice cedex 2 France
    Science 290:68-9. 2000
  44. ncbi Guidance of cell migration by the Drosophila PDGF/VEGF receptor
    P Duchek
    European Molecular Biology Laboratory, Developmental Biology Programme, 69117 Heidelberg, Germany
    Cell 107:17-26. 2001
    ..Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal.
  45. ncbi Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis
    Christian Ghiglione
    Department of Genetics, Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Development 129:175-86. 2002
    We have analyzed the mechanism of activation of the Epidermal growth factor receptor (Egfr) by the transforming growth factor (TGF) alpha-like molecule, Gurken (Grk)...
  46. ncbi Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline
    Marco Gallio
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 106 96 Stockholm, Sweden
    Development 131:3605-14. 2004
    ..Expression of dominant-negative Egfr or Ras induces midline crosses, whereas activation of the Egfr or Ras in the leading cell of the ganglionic branch ..
  47. ncbi Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila
    Ayelet Schlesinger
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Cell 7:535-45. 2004
    The Drosophila EGF receptor ligand Spitz is cleaved by Rhomboid to generate an active secreted molecule. Surprisingly, when a cleaved variant of Spitz (cSpi) was expressed, it accumulated in the ER, both in embryos and in cell culture...
  48. pmc Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster
    Ian Dworkin
    Department of Genetics, North Carolina State University, Raleigh, 27695 7614, USA
    Genetics 169:2115-25. 2005
    ..and a wild-caught cohort of Drosophila melanogaster, an association between a putative regulatory polymorphism in Egfr and wing shape can be replicated...
  49. ncbi Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila
    Clemens Cabernard
    Department of Biology, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 9:831-42. 2005
    ..Fgf signaling directs cell migration at the tip of the structure, while Egf signaling is instrumental for cell division and cell survival in the growing epithelial structure...
  50. ncbi Age-independent synaptogenesis by phosphoinositide 3 kinase
    Alfonso Martín-Peña
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 26:10199-208. 2006
    ..Thus, we propose that PI3K stimulation can be applied to prevent or delay synapse loss in normal aging and in neurological disorders...
  51. ncbi Signal transduction and the fate of the R7 photoreceptor in Drosophila
    G M Rubin
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Trends Genet 7:372-7. 1991
    ..Studies of the mechanisms governing the specificity of signal transmission and reception suggest that the sevenless signal directs a bipotential cell towards a neuronal rather than a cone cell fate...
  52. ncbi Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases
    R D Rogge
    Department of Biology, University of California, Los Angeles 90024
    Cell 64:39-48. 1991
    ..Mutations in Sos also interact with the Ellipse allele of the Drosophila EGF receptor. We propose a model suggesting that the Sos product is downstream of sevenless and the EGF receptor, and that ..
  53. ncbi The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development
    E D Schejter
    Department of Virology, Weizmann Institute of Science, Rehovot, Israel
    Cell 56:1093-104. 1989
    ..Mutations in DER were shown to be allelic to the previously described locus faint little ball.
  54. ncbi The Ras signaling pathway in Drosophila
    D A Wassarman
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California at Berkeley 94720 3200, USA
    Curr Opin Genet Dev 5:44-50. 1995
    ..The Ras cascade functions in other Drosophila signal transduction pathways, eliciting a distinct response in each case, presumably through phosphorylation of specific transcription factors...
  55. ncbi Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration
    M Reichman-Fried
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genes Dev 8:428-39. 1994
    ..Deregulated receptors containing the cytoplasmic domains of DFGF-R2, DER, torso, and sevenless were all able to partially rescue the migration defects...
  56. ncbi Crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster
    U Tepass
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
    Dev Biol 159:311-26. 1993
    ..Double mutant combinations of crb and sdt suggest that these genes are part of a common genetic pathway (crb/sdt pathway), in which sdt acts downstream of crb and is activated by the latter...
  57. ncbi The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway
    M A Sturtevant
    Department of Biology, University of California, San Diego
    Genes Dev 7:961-73. 1993
    ..The ventrolateral genes include spitz, which encodes an EGF-like ligand, and Star...
  58. ncbi Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis
    A M Morimoto
    Department of Biochemistry, University of Washington, Seattle 98195, USA
    Development 122:3745-54. 1996
    ..mid-oogenesis, Gurken is concentrated at the dorsal-anterior of the oocyte and is thought to activate the EGF receptor pathway in adjacent follicle cells. In response to this signal, dorsal follicle cell fate is determined...
  59. ncbi In situ activation pattern of Drosophila EGF receptor pathway during development
    L Gabay
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 277:1103-6. 1997
    ..Detection of the active state of the Drosophila epidermal growth factor receptor (DER) pathway allowed the visualization of gradients and boundaries of receptor activation, ..
  60. ncbi Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo
    A M Queenan
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, NJ 08544, USA
    Development 124:3871-80. 1997
    The Drosophila gene torpedo/Egfr (top/Egfr) encodes a homolog of the vertebrate Epidermal Growth Factor receptor. This receptor is required several times during the life cycle of the fly for the transmisson of developmental cues...
  61. ncbi The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis
    C Ghiglione
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:847-56. 1999
    We have identified the Drosophila transmembrane molecule kekkon 1 (kek1) as an inhibitor of the epidermal growth factor receptor (EGFR) and demonstrate that it acts in a negative feedback loop to modulate the activity of the EGFR tyrosine ..
  62. ncbi rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development
    A Guichard
    Department of Biology, University of California San Diego, La Jolla CA 92093 0349, USA
    Development 126:2663-76. 1999
    Genes of the ventrolateral group in Drosophila are dedicated to developmental regulation of Egfr signaling in multiple processes including wing vein development...
  63. ncbi The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development
    D J Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Development 126:3035-46. 1999
    ..New types of genetic screens promise to fill in some of these gaps in the near future...
  64. ncbi The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning
    J Culi
    Centro de Biologia Molecular Severo Ochoa, CSIC and UAM, Cantoblanco, Madrid, Spain
    Development 128:299-308. 2001
    ..trigger, in addition, positive interactions among cells of the cluster that are mediated by the Epidermal growth factor receptor (EGFR) and the Ras/Raf pathway...
  65. ncbi Regulated endocytic routing modulates wingless signaling in Drosophila embryos
    L Dubois
    National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, United Kingdom
    Cell 105:613-24. 2001
    ..This follows in part from the segmental activation of signaling by the epidermal growth factor receptor, which accelerates Wingless degradation at the posterior, thus leading to asymmetrical Wingless ..
  66. ncbi A function for Egf receptor signaling in expanding the developing brain in Drosophila
    Damon T Page
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 13:474-82. 2003
    ..Could the foregut substitute for neural midline cells and secrete signals that pattern this part of the brain?..
  67. ncbi Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1
    Christian Ghiglione
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Development 130:4483-93. 2003
    ..1 (Kek1) has previously been shown to act in a negative feedback loop to downregulate the Drosophila Epidermal Growth Factor Receptor (DER) during oogenesis...
  68. pmc Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila
    Anna T Chao
    Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
    Genetics 165:601-12. 2003
    ..Our findings have important implications for assigning null mutant phenotypes and for selecting appropriate alleles to use in suppressor screens...
  69. pmc Hrs mediates downregulation of multiple signalling receptors in Drosophila
    Gaspar Jekely
    European Molecular Biology Laboratory, Developmental Biology Program, Heidelberg, Germany
    EMBO Rep 4:1163-8. 2003
    ..signalling receptors in an endosomal compartment with high levels of ubiquitinated proteins: not only RTKs (EGFR and PVR) but also Notch and receptors for Hedgehog and Dpp (TGF-beta related)...
  70. ncbi Notch signaling: control of cell communication and cell fate
    Eric C Lai
    Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Development 131:965-73. 2004
    ..This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns...
  71. pmc Lozenge directly activates argos and klumpfuss to regulate programmed cell death
    Jill Wildonger
    Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University Medical School, New York, NY 10032, USA
    Genes Dev 19:1034-9. 2005
    ..These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development...
  72. ncbi Computational analysis of EGFR inhibition by Argos
    Gregory T Reeves
    Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, USA Lewis Sigler Institute for Integrative Genomics, Princeton University, Carl Icahn Laboratory, Washington Road, Princeton, NJ 08544, USA
    Dev Biol 284:523-35. 2005
    Argos, a secreted inhibitor of the Drosophila epidermal growth factor receptor, and the only known secreted receptor tyrosine kinase inhibitor, acts by sequestering the EGFR ligand Spitz...
  73. ncbi Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway
    Katherine E Brown
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Dev Biol 300:710-21. 2006
    ..Here, we report that the transcription factor Atonal and the canonical EGF receptor signalling cascade are both required for this clustering and for the accompanying changes in cellular adhesion...
  74. ncbi The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila
    Ciara M Gallagher
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 11:641-53. 2006
    ..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs...
  75. pmc Drosophila cbl is essential for control of cell death and cell differentiation during eye development
    Yuan Wang
    Department of Biochemistry and Molecular Biology, The University of Texas, M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 3:e1447. 2008
    ..E3-ubiquitin ligases plays a major role for the ligand-dependent inactivation of receptor tyrosine kinases (RTKs), most notably the Epidermal Growth Factor Receptor (EGFR) through ubiquitin-mediated endocytosis and lysosomal degradation.
  76. pmc Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway
    Raghavendra Nagaraj
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    EMBO J 28:337-46. 2009
    ..In Drosophila, the EGFR pathway transcriptionally activates phyl whose product then blocks Notch and Wg signalling pathways...
  77. ncbi The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Mech Dev 48:25-33. 1994
    ..Other members of the spitz group and the EGF receptor also interact with sev-rho, in a pattern that suggests a model in which rhomboid can act as a mediator of a ..
  78. ncbi The Drosophila TGF-alpha-like protein Gurken: expression and cellular localization during Drosophila oogenesis
    F S Neuman-Silberberg
    HHMI, Department of Molecular Biology, Princeton University, NJ 08544, USA
    Mech Dev 59:105-13. 1996
    ..Drosophila egg and embryo depends on the function of the genes gurken, cornichon and Egfr (Drosophila epidermal growth factor receptor homolog)...
  79. pmc Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development
    H Meisner
    Program in Molecular Medicine, University of Massachusetts Medical Center, Worcester 01605, USA
    Mol Cell Biol 17:2217-25. 1997
    ..elegans prevented tyrosine phosphorylation of D-Cbl as well as binding to the liganded EGF receptor in COS-1 cells...
  80. ncbi Local induction of patterning and programmed cell death in the developing Drosophila retina
    D T Miller
    Washington University School of Medicine, Department of Molecular Biology and Pharmacology, Box 8103, St Louis, MO 63110, USA
    Development 125:2327-35. 1998
    ..by supplying a 'life'-promoting activity; evidence is provided that this signal occurs through localized activation of the EGF Receptor/Ras pathway. Together, these signals refine the highly regular pattern observed in the adult retina.
  81. pmc Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction
    D Szuts
    Medical Research Council MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Genes Dev 12:2022-35. 1998
    ..with a permissive role in this process, namely Vein, a neuregulin-like ligand that stimulates the epidermal growth factor receptor (EGFR) and Ras signaling...
  82. ncbi Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation
    J P Kumar
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322 3030, USA
    Development 125:3875-85. 1998
    A new conditional Egfr allele was used to dissect the roles of the receptor in eye development and to test two published models...
  83. ncbi The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
    A Bergmann
    Massachusetts Institute of Technology, Howard Hughes Medical Institute, Department of Biology, Cambridge 02139, USA
    Cell 95:331-41. 1998
    ..These findings define a novel mechanism by which growth factor signaling directly inactivates a critical component of the intrinsic cell death machinery. These studies provide further insights into the function of ras as an oncogene...
  84. ncbi Hedgehog and Spitz: making a match between photoreceptor axons and their targets
    I Salecker
    Department of Biological Chemistry, Howard Hughes Medical Institute, The School of Medicine, University of California, Los Angeles 90095, USA
    Cell 95:587-90. 1998
  85. pmc Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm
    A Carmena
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma, 28049 Madrid, Spain
    Genes Dev 12:3910-22. 1998
    ..to a subsequent instructive signal mediated by two receptor tyrosine kinases (RTKs), the Drosophila epidermal growth factor receptor (DER) and the Heartless (Htl) fibroblast growth factor receptor...
  86. ncbi Sprouty, an intracellular inhibitor of Ras signaling
    T Casci
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 96:655-65. 1999
    Sprouty was identified in a genetic screen as an inhibitor of Drosophila EGF receptor signaling. The Egfr triggers cell recruitment in the eye, and sprouty- eyes have excess photoreceptors, cone cells, and pigment cells...
  87. ncbi Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila
    S Kramer
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 126:2515-25. 1999
    ..In each of these tissues, EGF receptor signaling is known to participate in the control of the correct number of neurons or glia...
  88. pmc Quantitative trait loci affecting components of wing shape in Drosophila melanogaster
    E Zimmerman
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 155:671-83. 2000
    ....
  89. ncbi Drawing lines in the Drosophila wing: initiation of wing vein development
    E Bier
    Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093 0349, USA
    Curr Opin Genet Dev 10:393-8. 2000
    ..As a consequence of this constraint, cells lying in a narrow line immediately outside the signal-producing domain are the only cells that can respond to the signal by activating expression of vein-promoting genes...
  90. ncbi brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling
    A Guichard
    Section of Cell and Developmental Biology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0349, USA
    Dev Biol 226:255-66. 2000
    The Drosophila rhomboid (rho) gene participates in localized activation of EGF-receptor signaling in various developmental settings...
  91. ncbi Receptor tyrosine kinases: specific outcomes from general signals
    M A Simon
    Department of Biological Sciences, Stanford University, California 94305, USA
    Cell 103:13-5. 2000
  92. ncbi A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye
    Sun Yun Yu
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 129:3269-78. 2002
    ..In the eye, the EGF receptor, Notch, and intact primary pigment and cone cells have been implicated in survival or death signals...
  93. ncbi Leg patterning driven by proximal-distal interactions and EGFR signaling
    M I Galindo
    School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Science 297:256-9. 2002
    ..structure, is instead defined by the activity of Distalless, dachshund, and a distal gradient of epidermal growth factor receptor (EGFR)-Ras signaling...
  94. ncbi Invasive cell migration is initiated by guided growth of long cellular extensions
    Tudor A Fulga
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Cell Biol 4:715-9. 2002
    ..The migration is guided by EGFR (epidermal growth factor receptor) and PVR (platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) receptor)...
  95. ncbi An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling
    Leo Tsuda
    Department of Biological Chemistry and Department of Human Genetics, Molecular Biology Institute, Los Angeles, CA 90095, USA
    Cell 110:625-37. 2002
    The Notch and Epidermal Growth Factor Receptor (EGFR) pathways both regulate proliferation and differentiation, and the cellular response to each is often influenced by the other...
  96. ncbi Patterning the fly eye: the role of apoptosis
    Carrie Baker Brachmann
    Developmental and Cell Biology, University of California, Irvine, 5205 McGaugh Hall, Irvine, CA 92697 2300, USA
    Trends Genet 19:91-6. 2003
    ..But, we have yet to understand how this signaling is regulated spatially to result in such precision. In this article, we describe and speculate on the role of selective cell death during maturation of the fly eye...
  97. ncbi Antagonistic relationship between Dpp and EGFR signaling in Drosophila head patterning
    Ting Chang
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Biol 263:103-13. 2003
    ..The eye field expresses and requires both Dpp and EGFR signaling for its development...
  98. ncbi Differential requirement of EGFR signaling for the expression of defective proventriculus gene in the Drosophila endoderm and ectoderm
    Tetsuya Shirai
    Graduate School of Natural and Science Technology, Okayama University, 3 1 1 Tsushima naka, Okayama 700 8530, Japan
    Biochem Biophys Res Commun 311:473-7. 2003
    ..of dve in the ventral ectoderm, in which dve expression is induced by Spitz, a ligand for Drosophila epidermal growth factor receptor (EGFR)...
  99. ncbi Regulation of notch signaling activity
    Francois Schweisguth
    CNRS UMR 8542, Ecole Normale Superieure, Paris, France
    Curr Biol 14:R129-38. 2004
    ..Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time...
  100. pmc Nucleotide variation in the Egfr locus of Drosophila melanogaster
    Arnar Palsson
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27513 7614, USA
    Genetics 167:1199-212. 2004
    The Epidermal growth factor receptor is an essential gene with diverse pleiotropic roles in development throughout the animal kingdom. Analysis of sequence diversity in 10.9 kb covering the complete coding region and 6...
  101. ncbi A role for wingless in an early pupal cell death event that contributes to patterning the Drosophila eye
    Julia Cordero
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Mech Dev 121:1523-30. 2004
    ..As with later PCD, this death is dependent on Notch activity. Surprisingly, altering Drosophila Epidermal Growth Factor Receptor or Ras pathway activity had no effect on this death...

Research Grants28

  1. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  2. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
  3. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
  4. Genome wide analysis and modeling of signal integration in the Drosophila ovary
    Stanislav Shvartsman; Fiscal Year: 2009
    ..Deregulated EGFR and BMP signaling are associated with severe developmental defects and a large number of human diseases...
  5. MSM: CR Multiscale analysis of epithelial patterning: m*
    Stanislav Shvartsman; Fiscal Year: 2007
    ..experiments and modeling to study the mechanisms by which developing epithelia are patterned by the Epidermal Growth Factor Receptor (EGFR), an evolutionary conserved regulator of tissues in animals from worms to humans...
  6. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
    ..The cross-disciplinary nature of this meeting will be attractive to molecular, cellular, developmental, and neurobiological scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
  7. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
    ..abstract_text> ..
  8. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....
  9. Development of tissue-specific cell lines in Drosophila
    Amanda Simcox; Fiscal Year: 2009
    ..Subsequent use of the cell lines by individual investigators to study diverse biological problems is expected to impact our understanding of human disease. ..
  10. DEVELOPMENTAL REGULATION OF GROWTH, SIZE AND SHAPE
    Nicholas E Baker; Fiscal Year: 2010
    ....
  11. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  12. RNA and the Etiology of Disease
    Joel Richter; Fiscal Year: 2008
    ..The meeting is cross-disciplinary in its approach, which is essential for combating human disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  13. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  14. Synaptic Glutamate Release in Drosphila
    Aaron DiAntonio; Fiscal Year: 2008
    ..The results of these experiments will provide novel and fundamental information on the mechanisms by which VGLUT contributes to the development and function of glutamatergic synapses. ..
  15. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
    ..Our work in Drosophila on the mechanisms and targets of these regulators' action will provide insight as to the underlying causes of these diseases and will help to reveal potential therapies. ..
  16. GENOMIC ANALYSES OF DROSOPHILA DEVELOPMENT
    Kevin White; Fiscal Year: 2008
    ..The methods we develop should be applicable and relevant to the human genome as well, which could be the subject of similar future studies. [unreadable] [unreadable]..
  17. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2001
    ..Finally, an mRNA that is deadenylated and stored in a dormant form in mouse oocytes undergoes prior CPE-mediated deadenylation. The possible role of mCPEB in the process will be assessed. ..
  18. Comparative Studies of Gene Regulation in Drosophila
    Kevin White; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  19. Analysis of BMP-4 activity in Cleavage mutant mice
    Jan Christian; Fiscal Year: 2007
    ..Understanding the molecular mechanisms by which BMP activity is regulated is key to understanding, treating and preventing congenital anomalies and diseases. [unreadable] [unreadable]..
  20. Tiling Path Microarray Re-amplifable Resource Drosophila
    Kevin White; Fiscal Year: 2006
    ..This feature of the proposed resource would enable comprehensive RNAi screens, rapid cloning of regulatory sequences, and potentially many other applications. ..
  21. Identification of extrinsic signals in blood formation
    Jan Christian; Fiscal Year: 2006
    ..Understanding how normal blood development occurs is crucial to understanding and preventing disease resulting from misregulation of these pathways. ..
  22. 2005 Structural, Functional and Evolutionary Genomics Gordon Conference
    Kevin White; Fiscal Year: 2005
    ..This conference aims to bring together leading researchers from the major sub-disciplines of genome science. It also serves to expose talented young investigators to cutting-edge research in this field. ..
  23. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  24. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
    ..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
  25. A Drosophilia Model of Amyotrophic Lateral Schlerosis
    Stephen Jackson; Fiscal Year: 2004
    ..Results from this work should clarify the normal cellular role of the ALS2 gene and may reveal strategies for treatment of ALS disease. ..
  26. Receptor Tyrosine Kinase Regulation of Nuclear Import
    Lizabeth Perkins; Fiscal Year: 2004
    ..g. Csw) directly participate in the process of nuclear import will contribute to a greater understanding of how signaling pathways control cellular growth and differentiation. ..
  27. Vascular cell migration and VHL gene function in flies
    Tien Hsu; Fiscal Year: 2003
    ..2) To assess the relevance of the potential D-VHL interacting proteins and complete the ongoing yeast 2-hybrid screen for D-VHL interacting proteins. (4) Generating genomic D-VHL mutant. ..
  28. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..