Dyrk3

Summary

Gene Symbol: Dyrk3
Description: Dual-specificity tyrosine phosphorylation-regulated kinase 3
Alias: BcDNA:RE60792, CG40478, DDYRK3, DYRK3, Dm3, DmDyrk3, Dmel\CG40478, FBtr0100406, CG40478 gene product from transcript CG40478-RE, CG40478-PA, CG40478-PC, CG40478-PE, Dyrk3-PA, Dyrk3-PC, Dyrk3-PE
Species: fruit fly

Top Publications

  1. pmc dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila
    Pamela A Lochhead
    The Beatson Institute for Cancer Research, Cancer Research UK, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Biochem J 374:381-91. 2003
  2. doi Global analysis of RNA secondary structure in two metazoans
    Fan Li
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Rep 1:69-82. 2012
  3. pmc Drosophila Dyrk2 plays a role in the development of the visual system
    Nathan Luebbering
    Department of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e76775. 2013
  4. pmc Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions
    Margarida L A Figueiredo
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS Genet 10:e1004865. 2014
  5. pmc cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four
    Fang Lin Sun
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Mol Cell Biol 24:8210-20. 2004
  6. doi Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases
    Ross Kinstrie
    1Department of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Sci Signal 3:ra16. 2010
  7. pmc Heterochromatin protein 1a is required for an open chromatin structure
    Diane E Cryderman
    Department of Biochemistry University of Iowa Iowa City, IA USA
    Transcription 2:95-99. 2011
  8. ncbi A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
    Yousang Gwack
    The CBR Institute for Biomedical Research and the Departments of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 441:646-50. 2006

Detail Information

Publications8

  1. pmc dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila
    Pamela A Lochhead
    The Beatson Institute for Cancer Research, Cancer Research UK, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Biochem J 374:381-91. 2003
    ..Finally, dDYRK2 is active at all stages of fly development, with elevated levels observed during embryogenesis and pupation...
  2. doi Global analysis of RNA secondary structure in two metazoans
    Fan Li
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Rep 1:69-82. 2012
    ..Overall, our findings provide a global assessment of RNA folding in animals...
  3. pmc Drosophila Dyrk2 plays a role in the development of the visual system
    Nathan Luebbering
    Department of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e76775. 2013
    ..Drosophila encodes three Dyrks: minibrain/Dyrk1A, DmDyrk2, and DmDyrk3. Here we describe the creation and characterization of a DmDyrk2 null allele, DmDyrk2(1w17) ...
  4. pmc Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions
    Margarida L A Figueiredo
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS Genet 10:e1004865. 2014
    ..We hypothesize that roX mutants reveal the ancient targeting of the MSL-complex and propose that the role of roX RNAs is to prevent the binding of the MSL-complex to heterochromatin. ..
  5. pmc cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four
    Fang Lin Sun
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Mol Cell Biol 24:8210-20. 2004
    ..We propose that heterochromatin formation is initiated at dispersed repetitive elements along the fourth chromosome and spreads for approximately 10 kb or until encountering competition from a euchromatic determinant...
  6. doi Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases
    Ross Kinstrie
    1Department of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK
    Sci Signal 3:ra16. 2010
    ..The conservation of the NAPA domain from trypanosomes to humans indicates that this form of intramolecular phosphorylation of the activation loop is ancient and may represent a primordial mechanism for the activation of protein kinases...
  7. pmc Heterochromatin protein 1a is required for an open chromatin structure
    Diane E Cryderman
    Department of Biochemistry University of Iowa Iowa City, IA USA
    Transcription 2:95-99. 2011
    ..We investigated a stock harboring a silenced transgene inserted into Dyrk3 and near Caps-two expressed genes on chromosome four...
  8. ncbi A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
    Yousang Gwack
    The CBR Institute for Biomedical Research and the Departments of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 441:646-50. 2006
    ..Thus, genetic screening in Drosophila can be successfully applied to cross evolutionary boundaries and identify new regulators of a transcription factor that is expressed only in vertebrates...