Genomes and Genes
Gene Symbol: DptB
Description: Diptericin B
Alias: 147473_at, BcDNA:RH29451, CG10794, DiptB, Diptericin, Dmel\CG10794, Dpt, diptB, dpt B, dptB, dptlp, CG10794 gene product from transcript CG10794-RA, CG10794-PA, Diptericin-B, DiptericinB, DptB-PA, diptercin B, diptericin, diptericin B, diptericin-like protein
Species: fruit fly
- Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in DrosophilaJ H Lee
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, South Korea
Gene 271:233-8. 2001Insects produce various anti-microbial peptides in response to injury and infection. In Drosophila, diptericin has previously been studied as an anti-bacterial immune response gene...
- Wolbachia-mediated antibacterial protection and immune gene regulation in DrosophilaZhee Sheen Wong
School of Biological Sciences, The University of Queensland, Brisbane, Queensland, Australia
PLoS ONE 6:e25430. 2011..are naturally infected with Wolbachia showed no upregulation of the antibacterial immune genes TepIV, Defensin, Diptericin B, PGRP-SD, Cecropin A1 and Attacin D compared to paired flies without Wolbachia...
- Genetic basis of natural variation in D. melanogaster antibacterial immunityBrian P Lazzaro
Department of Entomology, 4138 Comstock Hall, Cornell University, Ithaca, NY 14853, USA
Science 303:1873-6. 2004..Variation in these genes, therefore, seems to drive variability in immunocompetence among wild Drosophila...
- Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteriaBrian P Lazzaro
Department of Entomology, Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
Genetics 174:1539-54. 2006..lactis and E. faecalis, respectively, most of the molecular polymorphisms tested explain <10% of the total variance in bacterial load sustained after infection...
- Pirk is a negative regulator of the Drosophila Imd pathwayAnni Kleino
Institute of Medical Technology, University of Tampere, Finland
J Immunol 180:5413-22. 2008..Furthermore, pirk-overexpressing flies were more susceptible to Gram-negative bacterial infection than wild-type flies. We conclude that Pirk is a negative regulator of the Imd pathway...
- Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edinMichael D Gordon
Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Pathog 4:e1000111. 2008..These results are consistent with a model in which the regulation of host factors, including edin, must be tightly controlled to avoid the detrimental consequences of having too much or too little activity...
- Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencingTimothy B Sackton
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
BMC Genomics 10:259. 2009..However, limited functional annotation in non-model systems has hindered understanding of evolutionary novelties in the insect innate immune system...
- Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogasterYixin H Ye
School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia
PLoS Pathog 5:e1000385. 2009..aeruginosa infection than previously reported. This work reveals novel pathways by which Drosophila can survive infection with a virulent pathogen that may be rare in wild populations, however, due to their cost...
- Identification of new immune induced molecules in the haemolymph of Drosophila melanogaster by 2D-nanoLC MS/MSPeter Verleyen
Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
J Insect Physiol 52:379-88. 2006..Many of the identified peptides are post-translationally modified by an N-terminal pyroglutamic acid and/or a C-terminal amide. Haemolymph of control larvae was treated in the same way and revealed only one peptide...
- Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extensionAgnieszka Doroszuk
Evolutionary Biology, Institute of Biology, Leiden University, The Netherlands
BMC Genomics 13:167. 2012..We do this at two time points representing middle age (90% survival) and old age (10% survival) respectively, in three adult diets (malnutrition, optimal food, and overfeeding)...
- ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in DrosophilaAndrew J Petersen
Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 109:E656-64. 2012....
- How the fly balances its ability to combat different pathogensMoria C Chambers
Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
PLoS Pathog 8:e1002970. 2012..In addition, increased phagocytic activity is beneficial during S. pneumoniae infection but detrimental during L. monocytogenes infection, demonstrating an inherent trade-off in the immune response...
- The innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasiaAndrew J Petersen
Molecular and Cellular Pharmacology Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
Genetics 194:133-42. 2013..In summary, these findings suggest that neurodegeneration in human A-T is caused by activation of a specific NF-κB protein in glial cells...
- Pausing for thought: disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesisBarbara H Jennings
Transcriptional Regulation Group, UCL Cancer Institute, London, UK
Bioessays 35:553-60. 2013..Analysis of these mutations has revealed that control of transcriptional pausing is critical for a diverse range of biological pathways essential for animal development and survival...
- Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brainYang Cao
Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 110:E1752-60. 2013..These results provide a mechanistic link between innate immune responses and neurodegeneration and may have important implications for the role of neuroinflammation in human neurodegenerative diseases as well...
- Do the genes of the innate immune response contribute to neuroprotection in Drosophila?Rafael Cantera
Zoology Department, Stockholm University, Stockholm, Sweden
J Innate Immun 7:3-10. 2015..This review opens this debate in Drosophila, which could thus be used as an instrumental model to elucidate this question...
- Invertebrate models for coenzyme q10 deficiencyDaniel J M Fernández-Ayala
Centro Andaluz de Biologia del Desarrollo, Universidad Pablo Olavide CSIC, and CIBERER Instituto de Salud Carlos III, Seville, Spain
Mol Syndromol 5:170-9. 2014..In this review, we summarize several attempts to model reliable human CoQ deficiencies in invertebrates, focusing on mutant phenotypes pretty similar to those observed in human patients. ..
- A mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in DrosophilaXiaoping Sun
Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA
Cell Rep 8:1781-92. 2014..Our data reveal a link among diet, mitochondria, and MAPK and TOR signaling in aging and stresses the importance of considering genetic background and diet composition in implementing interventions for promoting healthy aging. ..
- Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegenerationLihong Zhan
Department of Human Oncology, Program in Molecular and Cellular Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Hum Mol Genet 24:757-72. 2015....
- Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasiaHaiyang Chen
Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA
Cell 159:829-43. 2014..paperflick:..
- All for one and one for all: Regionalization of the Drosophila intestineNicolas Buchon
Department of Entomology, Cornell University, Ithaca, NY 14853, USA Electronic address
Insect Biochem Mol Biol 67:2-8. 2015..Further characterization of the gene regulatory networks underlying gut compartmentalization will pave the way for a better understanding of gastrointestinal function in insects and mammals, in both health and disease conditions. ..
- Drosophila type IV collagen mutation associates with immune system activation and intestinal dysfunctionMárton Kiss
Department of Genetics, University of Szeged, Kozepfasor 52, H 6726 Szeged, Hungary
Matrix Biol 49:120-31. 2016..activation of the effector AMP genes of the primary innate immune system including Metchnikowin, Diptericin, Diptericin B, and edin that preceded morphological changes...
- The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling rolesMariam H Orme
Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary Jean Mitchell Green Building, 237 Fulham Road, London SW3 6JB, UK
Nat Commun 7:10972. 2016..Together, our results expose a conserved role for unconventional myosins in transducing caspase-dependent regulation of kinases, allowing them to take part in specific signalling events. ..
- An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replicationZhijing Huang
Department of Biology, Indiana University, Bloomington, Indiana, USA
J Virol 87:4272-80. 2013..We identified two antimicrobial peptide genes, attC and dptB, which are SINrep sensitive and regulated by STAT and Rel, respectively...
- The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42Christopher J Sampson
Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK
Dev Comp Immunol 38:160-8. 2012..Finally, Zir is dispensable for the humoral immune response against bacteria. We propose that Zir is necessary to activate the Rho-family GTPases Rac2 and Cdc42 during the Drosophila cellular immune response...
- Functional characterization of the infection-inducible peptide Edin in Drosophila melanogasterLeena Maija Vanha-Aho
BioMediTech and Institute of Biomedical Technology, University of Tampere, Tampere, Finland
PLoS ONE 7:e37153. 2012..faecalis infection via an uncharacterized mechanism. Further studies are still required to elucidate the exact role of Edin in the Drosophila immune response...
- Coenzyme Q plays opposing roles on bacteria/fungi and viruses in Drosophila innate immunityW Cheng
The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
Int J Immunogenet 38:331-7. 2011..We further showed that CoQ was essential for normal induction of anti-microbial peptides and amplification of viruses. Our work determined CoQ content in Drosophila and described its function in immunity for the first time...
- The relative importance of innate immune priming in Wolbachia-mediated dengue interferenceEdwige Rancès
School of Biological Sciences, Monash University, Clayton, Australia
PLoS Pathog 8:e1002548. 2012....
- Adult Drosophila melanogaster evolved for antibacterial defense invest in infection-induced expression of both humoral and cellular immunity genesYixin H Ye
School of Biological Sciences, Monash University, Melbourne, VIC 3800, Australia
BMC Res Notes 4:305. 2011....
- Reciprocal analysis of Francisella novicida infections of a Drosophila melanogaster model reveal host-pathogen conflicts mediated by reactive oxygen and imd-regulated innate immune responseMadeleine G Moule
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Pathog 6:e1001065. 2010..Our work suggests that there may be more to learn about the fly immune system, as not all of the phenotypes we observe can be readily explained by its interactions with known immune responses...
- Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogasterKeetae Kim
Department of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, Newark, NJ 07103, United States
Exp Gerontol 45:984-7. 2010..We also showed that development at a lower temperature represented by 18°C significantly downregulates anti-microbial peptide genes, AttA and DptB, of Imd pathway.
- Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflictBernardo Lemos
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 107:15826-31. 2010....
- Experimental selection for Drosophila survival in extremely high O2 environmentsHuiwen W Zhao
Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 5:e11701. 2010..genes including Tropomyosin 1, Glycerol 3 phosphate dehydrogenase, CG33129, and UGP as well as up-regulation of Diptericin and Attacin conferred tolerance to severe hyperoxia...
- The hydroxyproline motif of male sex peptide elicits the innate immune response in Drosophila femalesElena V Domanitskaya
Zoologisches Institut Universität Zürich Irchel, Zurich, Switzerland
FEBS J 274:5659-68. 2007..We suggest that SP acts by chemical mimicry of sugar components of the bacterial cell wall. Thus, SP may induce the immune system via pattern recognition receptors...
- Expression and evolution of the Drosophila attacin/diptericin gene familyM Hedengren
Umea Centre for Molecular Pathogenesis, Umea University, Umea, S 901 87, Sweden
Biochem Biophys Res Commun 279:574-81. 2000..the genes for three new glycine-rich antimicrobial peptides in Drosophila, two attacins (AttC and AttD) and one diptericin (DptB)...
- Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genesDeniz Erturk-Hasdemir
Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 106:9779-84. 2009..Instead they are critical for recruitment of RNA polymerase II and antimicrobial peptide gene induction, whereas IKK functions noncatalytically to support Dredd-mediated cleavage of Relish...
- SK66-his, a novel glycine-rich peptide derived from Drosophila with antibacterial activityZhiguo Feng
Key Laboratory of Molecular Biophysics, Ministry of Education, Huazhong University of Science and Technology, Wuhan, Hubei, China
Biosci Biotechnol Biochem 73:769-71. 2009..063 mg/l). It showed significant activity against Gram-positive bacteria. We determined a MIC value of 9 microg ml(-1) with Bacillus thuringiensis...
- A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defenseTheodore Tsichritzis
Institute of Immunology, Biomedical Sciences Research Center Al Fleming, 34 Al Fleming Street, 16672 Vari, Greece
Development 134:2605-14. 2007..All mutant phenotypes described were reversible upon conditional expression of CYLD transgenes. Our results implicate CYLD in a broad range of functions associated with fat homeostasis and host defence in Drosophila...
- In silico identification of new secretory peptide genes in Drosophila melanogasterFeng Liu
Laboratory for Developmental Physiology, Genomics, and Proteomics, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
Mol Cell Proteomics 5:510-22. 2006..This bioinformatic study opens perspectives for the genome-wide analysis of peptide genes in other eukaryotic model organisms...
- A Drosophila p38 orthologue is required for environmental stress responsesCaroline R Craig
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110, USA
EMBO Rep 5:1058-63. 2004..These phenotypes only partially overlap those caused by mutations in D-MEKK1 and dTAK1, suggesting that the D-p38a gene is required to mediate some, but not all, of the functions ascribed to p38 signalling...
- Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathwaysGuang Ho Cha
National Creative Research Initiatives Center for Cell Growth Regulation, and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, Republic of Korea
Mol Cell Biol 23:7982-91. 2003..NF-kappaBs, DIF and Relish, consequently activating the transcription of the antimicrobial peptide genes diptericin, diptericin-like protein, and drosomycin...
- Evolutionary Genomics of Anti-Malaria Genes in MosquitoBrian P Lazzaro; Fiscal Year: 2010..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..