DptB

Summary

Gene Symbol: DptB
Description: Diptericin B
Alias: 147473_at, BcDNA:RH29451, CG10794, DiptB, Diptericin, Dmel\CG10794, Dpt, diptB, dpt B, dptB, dptlp, CG10794 gene product from transcript CG10794-RA, CG10794-PA, Diptericin-B, DiptericinB, DptB-PA, diptercin B, diptericin, diptericin B, diptericin-like protein
Species: fruit fly

Top Publications

  1. ncbi Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila
    J H Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, South Korea
    Gene 271:233-8. 2001
  2. pmc Wolbachia-mediated antibacterial protection and immune gene regulation in Drosophila
    Zhee Sheen Wong
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 6:e25430. 2011
  3. ncbi Genetic basis of natural variation in D. melanogaster antibacterial immunity
    Brian P Lazzaro
    Department of Entomology, 4138 Comstock Hall, Cornell University, Ithaca, NY 14853, USA
    Science 303:1873-6. 2004
  4. pmc Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria
    Brian P Lazzaro
    Department of Entomology, Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 174:1539-54. 2006
  5. ncbi Pirk is a negative regulator of the Drosophila Imd pathway
    Anni Kleino
    Institute of Medical Technology, University of Tampere, Finland
    J Immunol 180:5413-22. 2008
  6. pmc Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin
    Michael D Gordon
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 4:e1000111. 2008
  7. pmc Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing
    Timothy B Sackton
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    BMC Genomics 10:259. 2009
  8. pmc Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster
    Yixin H Ye
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia
    PLoS Pathog 5:e1000385. 2009
  9. ncbi Identification of new immune induced molecules in the haemolymph of Drosophila melanogaster by 2D-nanoLC MS/MS
    Peter Verleyen
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    J Insect Physiol 52:379-88. 2006
  10. pmc Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension
    Agnieszka Doroszuk
    Evolutionary Biology, Institute of Biology, Leiden University, The Netherlands
    BMC Genomics 13:167. 2012

Research Grants

Scientific Experts

  • BRIAN LAZZARO
  • Agnieszka Doroszuk
  • Nicolas Buchon
  • Barbara H Jennings
  • Elizabeth A McGraw
  • Peter Verleyen
  • Timothy B Sackton
  • Bernardo Lemos
  • Andrew J Petersen
  • Yixin H Ye
  • Susanna Valanne
  • Mika Ramet
  • Dan Hultmark
  • Leena Maija Vanha-Aho
  • David S Schneider
  • Anni Kleino
  • Mariam H Orme
  • Márton Kiss
  • Rafael Cantera
  • Lihong Zhan
  • Haiyang Chen
  • Xiaoping Sun
  • Daniel J M Fernández-Ayala
  • Yang Cao
  • Zhijing Huang
  • David A Wassarman
  • Pascal Meier
  • Edwige Rancès
  • Moria C Chambers
  • Christopher J Sampson
  • W Cheng
  • Zhee Sheen Wong
  • Keetae Kim
  • Johanna Ulvila
  • Huiwen W Zhao
  • Madeleine G Moule
  • Zhiguo Feng
  • Deniz Erturk-Hasdemir
  • Michael D Gordon
  • Theodore Tsichritzis
  • Elena V Domanitskaya
  • Feng Liu
  • Caroline R Craig
  • Celia Monteiro Domingues
  • Tencho Tenev
  • David Williams
  • Paulo S Ribeiro
  • Meghana Tare
  • Katalin Csiszar
  • Nikoletta Popovics
  • Nina Moderau
  • Rebecca Feltham
  • Katiuscia Bianchi
  • Otto Morris
  • Edit Hermesz
  • Matthias Gstaiger
  • David Robertson
  • Alexander Wepf
  • Lior Aram
  • Andreas Bergmann
  • Rebecca Wilson
  • András A Kiss
  • Eli Arama
  • Gianmaria Liccardi
  • Matyas Mink
  • Sidonie Wicky-John
  • Guang Ho Cha
  • Monika Radics
  • Rosa Barrio
  • Randal S Tibbetts
  • Qijing Xie
  • Sige Zou
  • Qisheng Song
  • Placido Navas
  • Jason Yolitz
  • Mara Laslo
  • Sandra Jiménez-Gancedo
  • Thomas Alberico
  • Yixian Zheng
  • Yaning Sun
  • Ignacio Guerra
  • Charles T Wheeler
  • Xiaobin Zheng
  • Rebeccah J Katzenberger
  • Vasanthi Avadhanula
  • Richard W Hardy
  • Barry Ganetzky
  • Megan B Kingsolver
  • Stanislava Chtarbanova
  • Bettina Wilke

Detail Information

Publications41

  1. ncbi Diptericin-like protein: an immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila
    J H Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, South Korea
    Gene 271:233-8. 2001
    Insects produce various anti-microbial peptides in response to injury and infection. In Drosophila, diptericin has previously been studied as an anti-bacterial immune response gene...
  2. pmc Wolbachia-mediated antibacterial protection and immune gene regulation in Drosophila
    Zhee Sheen Wong
    School of Biological Sciences, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 6:e25430. 2011
    ..are naturally infected with Wolbachia showed no upregulation of the antibacterial immune genes TepIV, Defensin, Diptericin B, PGRP-SD, Cecropin A1 and Attacin D compared to paired flies without Wolbachia...
  3. ncbi Genetic basis of natural variation in D. melanogaster antibacterial immunity
    Brian P Lazzaro
    Department of Entomology, 4138 Comstock Hall, Cornell University, Ithaca, NY 14853, USA
    Science 303:1873-6. 2004
    ..Variation in these genes, therefore, seems to drive variability in immunocompetence among wild Drosophila...
  4. pmc Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria
    Brian P Lazzaro
    Department of Entomology, Field of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 174:1539-54. 2006
    ..lactis and E. faecalis, respectively, most of the molecular polymorphisms tested explain <10% of the total variance in bacterial load sustained after infection...
  5. ncbi Pirk is a negative regulator of the Drosophila Imd pathway
    Anni Kleino
    Institute of Medical Technology, University of Tampere, Finland
    J Immunol 180:5413-22. 2008
    ..Furthermore, pirk-overexpressing flies were more susceptible to Gram-negative bacterial infection than wild-type flies. We conclude that Pirk is a negative regulator of the Imd pathway...
  6. pmc Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin
    Michael D Gordon
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 4:e1000111. 2008
    ..These results are consistent with a model in which the regulation of host factors, including edin, must be tightly controlled to avoid the detrimental consequences of having too much or too little activity...
  7. pmc Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing
    Timothy B Sackton
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    BMC Genomics 10:259. 2009
    ..However, limited functional annotation in non-model systems has hindered understanding of evolutionary novelties in the insect innate immune system...
  8. pmc Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster
    Yixin H Ye
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland, Australia
    PLoS Pathog 5:e1000385. 2009
    ..aeruginosa infection than previously reported. This work reveals novel pathways by which Drosophila can survive infection with a virulent pathogen that may be rare in wild populations, however, due to their cost...
  9. ncbi Identification of new immune induced molecules in the haemolymph of Drosophila melanogaster by 2D-nanoLC MS/MS
    Peter Verleyen
    Laboratory of Developmental Physiology, Genomics and Proteomics, K U Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    J Insect Physiol 52:379-88. 2006
    ..Many of the identified peptides are post-translationally modified by an N-terminal pyroglutamic acid and/or a C-terminal amide. Haemolymph of control larvae was treated in the same way and revealed only one peptide...
  10. pmc Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension
    Agnieszka Doroszuk
    Evolutionary Biology, Institute of Biology, Leiden University, The Netherlands
    BMC Genomics 13:167. 2012
    ..We do this at two time points representing middle age (90% survival) and old age (10% survival) respectively, in three adult diets (malnutrition, optimal food, and overfeeding)...
  11. pmc ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila
    Andrew J Petersen
    Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 109:E656-64. 2012
    ....
  12. pmc How the fly balances its ability to combat different pathogens
    Moria C Chambers
    Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
    PLoS Pathog 8:e1002970. 2012
    ..In addition, increased phagocytic activity is beneficial during S. pneumoniae infection but detrimental during L. monocytogenes infection, demonstrating an inherent trade-off in the immune response...
  13. pmc The innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasia
    Andrew J Petersen
    Molecular and Cellular Pharmacology Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Genetics 194:133-42. 2013
    ..In summary, these findings suggest that neurodegeneration in human A-T is caused by activation of a specific NF-κB protein in glial cells...
  14. pmc Pausing for thought: disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis
    Barbara H Jennings
    Transcriptional Regulation Group, UCL Cancer Institute, London, UK
    Bioessays 35:553-60. 2013
    ..Analysis of these mutations has revealed that control of transcriptional pausing is critical for a diverse range of biological pathways essential for animal development and survival...
  15. pmc Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain
    Yang Cao
    Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 110:E1752-60. 2013
    ..These results provide a mechanistic link between innate immune responses and neurodegeneration and may have important implications for the role of neuroinflammation in human neurodegenerative diseases as well...
  16. doi Do the genes of the innate immune response contribute to neuroprotection in Drosophila?
    Rafael Cantera
    Zoology Department, Stockholm University, Stockholm, Sweden
    J Innate Immun 7:3-10. 2015
    ..This review opens this debate in Drosophila, which could thus be used as an instrumental model to elucidate this question...
  17. pmc Invertebrate models for coenzyme q10 deficiency
    Daniel J M Fernández-Ayala
    Centro Andaluz de Biologia del Desarrollo, Universidad Pablo Olavide CSIC, and CIBERER Instituto de Salud Carlos III, Seville, Spain
    Mol Syndromol 5:170-9. 2014
    ..In this review, we summarize several attempts to model reliable human CoQ deficiencies in invertebrates, focusing on mutant phenotypes pretty similar to those observed in human patients. ..
  18. pmc A mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in Drosophila
    Xiaoping Sun
    Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA
    Cell Rep 8:1781-92. 2014
    ..Our data reveal a link among diet, mitochondria, and MAPK and TOR signaling in aging and stresses the importance of considering genetic background and diet composition in implementing interventions for promoting healthy aging. ..
  19. pmc Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration
    Lihong Zhan
    Department of Human Oncology, Program in Molecular and Cellular Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Hum Mol Genet 24:757-72. 2015
    ....
  20. pmc Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia
    Haiyang Chen
    Department of Embryology, Carnegie Institution for Science, Baltimore, MD 21218, USA
    Cell 159:829-43. 2014
    ..paperflick:..
  21. doi All for one and one for all: Regionalization of the Drosophila intestine
    Nicolas Buchon
    Department of Entomology, Cornell University, Ithaca, NY 14853, USA Electronic address
    Insect Biochem Mol Biol 67:2-8. 2015
    ..Further characterization of the gene regulatory networks underlying gut compartmentalization will pave the way for a better understanding of gastrointestinal function in insects and mammals, in both health and disease conditions. ..
  22. doi Drosophila type IV collagen mutation associates with immune system activation and intestinal dysfunction
    Márton Kiss
    Department of Genetics, University of Szeged, Kozepfasor 52, H 6726 Szeged, Hungary
    Matrix Biol 49:120-31. 2016
    ..activation of the effector AMP genes of the primary innate immune system including Metchnikowin, Diptericin, Diptericin B, and edin that preceded morphological changes...
  23. pmc The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
    Mariam H Orme
    Chester Beatty Laboratories, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary Jean Mitchell Green Building, 237 Fulham Road, London SW3 6JB, UK
    Nat Commun 7:10972. 2016
    ..Together, our results expose a conserved role for unconventional myosins in transducing caspase-dependent regulation of kinases, allowing them to take part in specific signalling events. ..
  24. pmc An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replication
    Zhijing Huang
    Department of Biology, Indiana University, Bloomington, Indiana, USA
    J Virol 87:4272-80. 2013
    ..We identified two antimicrobial peptide genes, attC and dptB, which are SINrep sensitive and regulated by STAT and Rel, respectively...
  25. doi The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42
    Christopher J Sampson
    Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK
    Dev Comp Immunol 38:160-8. 2012
    ..Finally, Zir is dispensable for the humoral immune response against bacteria. We propose that Zir is necessary to activate the Rho-family GTPases Rac2 and Cdc42 during the Drosophila cellular immune response...
  26. pmc Functional characterization of the infection-inducible peptide Edin in Drosophila melanogaster
    Leena Maija Vanha-Aho
    BioMediTech and Institute of Biomedical Technology, University of Tampere, Tampere, Finland
    PLoS ONE 7:e37153. 2012
    ..faecalis infection via an uncharacterized mechanism. Further studies are still required to elucidate the exact role of Edin in the Drosophila immune response...
  27. doi Coenzyme Q plays opposing roles on bacteria/fungi and viruses in Drosophila innate immunity
    W Cheng
    The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian, China
    Int J Immunogenet 38:331-7. 2011
    ..We further showed that CoQ was essential for normal induction of anti-microbial peptides and amplification of viruses. Our work determined CoQ content in Drosophila and described its function in immunity for the first time...
  28. pmc The relative importance of innate immune priming in Wolbachia-mediated dengue interference
    Edwige Rancès
    School of Biological Sciences, Monash University, Clayton, Australia
    PLoS Pathog 8:e1002548. 2012
    ....
  29. pmc Adult Drosophila melanogaster evolved for antibacterial defense invest in infection-induced expression of both humoral and cellular immunity genes
    Yixin H Ye
    School of Biological Sciences, Monash University, Melbourne, VIC 3800, Australia
    BMC Res Notes 4:305. 2011
    ....
  30. pmc Reciprocal analysis of Francisella novicida infections of a Drosophila melanogaster model reveal host-pathogen conflicts mediated by reactive oxygen and imd-regulated innate immune response
    Madeleine G Moule
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Pathog 6:e1001065. 2010
    ..Our work suggests that there may be more to learn about the fly immune system, as not all of the phenotypes we observe can be readily explained by its interactions with known immune responses...
  31. doi Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster
    Keetae Kim
    Department of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, Newark, NJ 07103, United States
    Exp Gerontol 45:984-7. 2010
    ..We also showed that development at a lower temperature represented by 18°C significantly downregulates anti-microbial peptide genes, AttA and DptB, of Imd pathway.
  32. pmc Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict
    Bernardo Lemos
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:15826-31. 2010
    ....
  33. pmc Experimental selection for Drosophila survival in extremely high O2 environments
    Huiwen W Zhao
    Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e11701. 2010
    ..genes including Tropomyosin 1, Glycerol 3 phosphate dehydrogenase, CG33129, and UGP as well as up-regulation of Diptericin and Attacin conferred tolerance to severe hyperoxia...
  34. ncbi The hydroxyproline motif of male sex peptide elicits the innate immune response in Drosophila females
    Elena V Domanitskaya
    Zoologisches Institut Universität Zürich Irchel, Zurich, Switzerland
    FEBS J 274:5659-68. 2007
    ..We suggest that SP acts by chemical mimicry of sugar components of the bacterial cell wall. Thus, SP may induce the immune system via pattern recognition receptors...
  35. ncbi Expression and evolution of the Drosophila attacin/diptericin gene family
    M Hedengren
    Umea Centre for Molecular Pathogenesis, Umea University, Umea, S 901 87, Sweden
    Biochem Biophys Res Commun 279:574-81. 2000
    ..the genes for three new glycine-rich antimicrobial peptides in Drosophila, two attacins (AttC and AttD) and one diptericin (DptB)...
  36. pmc Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes
    Deniz Erturk-Hasdemir
    Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:9779-84. 2009
    ..Instead they are critical for recruitment of RNA polymerase II and antimicrobial peptide gene induction, whereas IKK functions noncatalytically to support Dredd-mediated cleavage of Relish...
  37. ncbi SK66-his, a novel glycine-rich peptide derived from Drosophila with antibacterial activity
    Zhiguo Feng
    Key Laboratory of Molecular Biophysics, Ministry of Education, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Biosci Biotechnol Biochem 73:769-71. 2009
    ..063 mg/l). It showed significant activity against Gram-positive bacteria. We determined a MIC value of 9 microg ml(-1) with Bacillus thuringiensis...
  38. ncbi A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense
    Theodore Tsichritzis
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, 34 Al Fleming Street, 16672 Vari, Greece
    Development 134:2605-14. 2007
    ..All mutant phenotypes described were reversible upon conditional expression of CYLD transgenes. Our results implicate CYLD in a broad range of functions associated with fat homeostasis and host defence in Drosophila...
  39. ncbi In silico identification of new secretory peptide genes in Drosophila melanogaster
    Feng Liu
    Laboratory for Developmental Physiology, Genomics, and Proteomics, Katholieke Universiteit Leuven, Naamsestraat 59, B 3000 Leuven, Belgium
    Mol Cell Proteomics 5:510-22. 2006
    ..This bioinformatic study opens perspectives for the genome-wide analysis of peptide genes in other eukaryotic model organisms...
  40. pmc A Drosophila p38 orthologue is required for environmental stress responses
    Caroline R Craig
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110, USA
    EMBO Rep 5:1058-63. 2004
    ..These phenotypes only partially overlap those caused by mutations in D-MEKK1 and dTAK1, suggesting that the D-p38a gene is required to mediate some, but not all, of the functions ascribed to p38 signalling...
  41. pmc Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways
    Guang Ho Cha
    National Creative Research Initiatives Center for Cell Growth Regulation, and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, Republic of Korea
    Mol Cell Biol 23:7982-91. 2003
    ..NF-kappaBs, DIF and Relish, consequently activating the transcription of the antimicrobial peptide genes diptericin, diptericin-like protein, and drosomycin...

Research Grants1

  1. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..