dpp

Summary

Gene Symbol: dpp
Description: decapentaplegic
Alias: BMP, CG9885, DPP, DPP-C, Dm-DPP, Dmel\CG9885, Dpp, Hin-d, M(2)23AB, M(2)LS1, TGF-b, TGF-beta, TGF-betagr;/SMAD, TGFbeta, blk, l(2)10638, l(2)22Fa, l(2)k17036, shv, CG9885 gene product from transcript CG9885-RA, CG9885-PA, CG9885-PB, CG9885-PC, CG9885-PE, Decapentaplegic/Bone morphogenetic protein, Haplo-insufficient, blink, bone morphogenetic protein, bone morphogenic protein, dpp-PA, dpp-PB, dpp-PC, dpp-PE, heldout, shortvein, tegula
Species: fruit fly

Top Publications

  1. ncbi The Hedgehog response network: sensors, switches, and routers
    Lawrence Lum
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 304:1755-9. 2004
  2. ncbi decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
    T Xie
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Cell 94:251-60. 1998
  3. pmc PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
    Hongge Jia
    Sealy Center for Cancer Cell Biology, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Development 136:307-16. 2009
  4. pmc Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo
    H Zhang
    Department Molecular Cell Biology, Division of Genetics and Development, University of California, Berkeley, California 94720, USA
    Genes Dev 15:261-6. 2001
  5. ncbi The role of Dpp and its inhibitors during eggshell patterning in Drosophila
    Bhupendra V Shravage
    Institute of Developmental Biology, University of Cologne, Gyrhofstr 17, D 50931, Germany
    Development 134:2261-71. 2007
  6. ncbi Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm
    M Boyle
    The Rockefeller University, NYC, NY 10021 6399, USA
    Development 124:971-82. 1997
  7. ncbi A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
    M Strigini
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 124:4697-705. 1997
  8. ncbi Notch signalling and the initiation of neural development in the Drosophila eye
    A Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 128:3889-98. 2001
  9. ncbi Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
  10. ncbi Lipoprotein-heparan sulfate interactions in the Hh pathway
    Christina Eugster
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Cell 13:57-71. 2007

Research Grants

  1. Transgenic analysis of Smad tumor suppressor genes
    Stuart Newfeld; Fiscal Year: 2006
  2. Analysis of BMP-4 activity in Cleavage mutant mice
    Jan Christian; Fiscal Year: 2007
  3. GORDON RESEARCH CONFERENCE ON PROTEOGLYCANS
    ARTHUR LANDER; Fiscal Year: 2002
  4. TRAINING PROGRAM IN CELLULAR AND MOLECULAR NEUROSCIENCE
    ARTHUR LANDER; Fiscal Year: 2007
  5. Identification of extrinsic signals in blood formation
    Jan Christian; Fiscal Year: 2006
  6. Transport and Complexity in Biological Systems
    ARTHUR LANDER; Fiscal Year: 2004
  7. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2004
  8. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
  9. Nucleocytoplasmic Trafficking of Smads
    Lan Xu; Fiscal Year: 2008
  10. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2007

Detail Information

Publications254 found, 100 shown here

  1. ncbi The Hedgehog response network: sensors, switches, and routers
    Lawrence Lum
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 304:1755-9. 2004
    ....
  2. ncbi decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
    T Xie
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Cell 94:251-60. 1998
    ..Here we show that the BMP2/4 homolog decapentaplegic (dpp) is specifically required to maintain female germline stem cells and promote their division...
  3. pmc PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation
    Hongge Jia
    Sealy Center for Cancer Cell Biology, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Development 136:307-16. 2009
    ..Taken together, our results suggest that PP4 and PP2A are two phosphatases that act at different positions of the Hh signaling cascade...
  4. pmc Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo
    H Zhang
    Department Molecular Cell Biology, Division of Genetics and Development, University of California, Berkeley, California 94720, USA
    Genes Dev 15:261-6. 2001
    A Dpp activity gradient specifies multiple thresholds of gene expression in the dorsal ectoderm of the early embryo...
  5. ncbi The role of Dpp and its inhibitors during eggshell patterning in Drosophila
    Bhupendra V Shravage
    Institute of Developmental Biology, University of Cologne, Gyrhofstr 17, D 50931, Germany
    Development 134:2261-71. 2007
    ..of the epidermal growth factor [EGF; Gurken (Grk)] and transforming growth factor beta [TGF-beta; Decapentaplegic (Dpp)] signaling cascades...
  6. ncbi Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm
    M Boyle
    The Rockefeller University, NYC, NY 10021 6399, USA
    Development 124:971-82. 1997
    ..Thus, these studies identify essential regulators of gonadal precursor specification and differentiation and reveal novel aspects of the general mechanism whereby distinct fates are allocated within the mesoderm...
  7. ncbi A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
    M Strigini
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 124:4697-705. 1997
    ..we show that Hh acts directly to pattern the central region of the wing, in addition to its role as an inducer of Dpp. Comparing the biological activities of secreted and membrane-tethered Hh provides evidence that Hh forms a local ..
  8. ncbi Notch signalling and the initiation of neural development in the Drosophila eye
    A Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 128:3889-98. 2001
    Neural determination in the Drosophila eye occurs progressively. A diffusible signal, Dpp, causes undetermined cells first to adopt a 'pre-proneural' state in which they are primed to start differentiating...
  9. ncbi Multiplex detection of RNA expression in Drosophila embryos
    Dave Kosman
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 305:846. 2004
    ....
  10. ncbi Lipoprotein-heparan sulfate interactions in the Hh pathway
    Christina Eugster
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Dev Cell 13:57-71. 2007
    ..They further suggest that the complement of proteins present on lipoprotein particles can regulate the activity of morphogens...
  11. ncbi Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis
    Beatriz García Fernández
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Mech Dev 124:884-97. 2007
    ..Genetic analysis has shown that signalling through Jun N-terminal Kinase (JNK) and Decapentaplegic (Dpp), a Drosophila member of the BMP/TGF-beta family of secreted factors, controls these activities...
  12. pmc G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling
    Stacey K Ogden
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Nature 456:967-70. 2008
    ..Our results demonstrate that Smo functions as a canonical GPCR, which signals through Galphai to regulate Hh pathway activation...
  13. doi The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc
    Ainhoa Pérez-Garijo
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Development 136:1169-77. 2009
    ..The finding that apoptotic cells ectopically express dpp and wg suggested that ectopic Dpp/Wg signalling might be responsible for compensatory proliferation...
  14. ncbi Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
    Sergey Apionishev
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Nat Cell Biol 7:86-92. 2005
    ....
  15. pmc Krüppel homolog 1 (Kr-h1) mediates juvenile hormone action during metamorphosis of Drosophila melanogaster
    Chieka Minakuchi
    Department of Biology, University of Washington, Seattle, WA 98195 1800, USA
    Mech Dev 125:91-105. 2008
    ..We also show for the first time that the JH-mediated maintenance of br expression in this epidermis is patterned and that JH delays the fusion of the imaginal cells and the disappearance of Dpp in the dorsal midline.
  16. ncbi Dual roles for patched in sequestering and transducing Hedgehog
    Y Chen
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 87:553-63. 1996
    ..Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement...
  17. ncbi Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis
    Eihachiro Kawase
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 131:1365-75. 2004
    ..Somatic cyst cells and hub cells express two Bmp molecules, Gbb and Dpp. Our genetic analysis indicates that gbb functions cooperatively with dpp to maintain male GSCs, although gbb alone ..
  18. ncbi Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction
    Hsiu Hsiang Lee
    Brookdale Department of Molecular, Cell and Developmental Biology, Box 1026, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 132:1429-42. 2005
    ..b>Dpp signals are required in cooperation with the mesoderm-specific NK homeodomain transcription factor Tinman (Tin) to ..
  19. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  20. ncbi Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein
    Andreu Casali
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Nature 431:76-80. 2004
    ..These results support a model in which the ratio of bound to unbound Ptc molecules determines the cellular response to Hh...
  21. pmc Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface
    Takuya Akiyama
    Department of Genetics, Cell Biology and Development, The University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 313:408-19. 2008
    Decapentaplegic (Dpp), a Drosophila homologue of bone morphogenetic proteins, acts as a morphogen to regulate patterning along the anterior-posterior axis of the developing wing...
  22. ncbi Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax
    Ella Tour
    Section in Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 132:5271-81. 2005
    ..These results suggest that the N-terminal region containing the SSYF motif has been conserved in many Hox proteins for its role in transcriptional activation...
  23. ncbi Mobilization of hobo elements residing within the decapentaplegic gene complex: suggestion of a new hybrid dysgenesis system in Drosophila melanogaster
    R K Blackman
    Cell 49:497-505. 1987
    ..Using strains with a hobo element inserted within the decapentaplegic gene complex (DPP-C), we have recovered numerous DPP-C mutations involving chromosomal rearrangements and deletions with one endpoint ..
  24. ncbi Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
    P W Ingham
    Molecular Embryology Laboratory, Imperial Cancer Research Fund, London, UK
    Curr Biol 5:432-40. 1995
    ..Both of these functions suggest a role for hedgehog family proteins as morphogens. An alternative possibility, however, is that hh and its homologues act to control the expression of other instructive signalling molecules...
  25. ncbi smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
    M van den Heuvel
    Molecular Embryology Laboratory, Imperial Cancer Research Fund, London, UK
    Nature 382:547-51. 1996
    ..This structure is typical of G-protein-coupled receptors, suggesting that the Smoothened protein may act as a receptor for the Hedgehog ligand...
  26. ncbi Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals
    P Das
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854 8020, USA
    Genes Cells 4:123-34. 1999
    Much is known about the three subfamilies of the TGFbeta superfamily in vertebrates-the TGFbetas, dpp/BMPs, and activins. Signalling in each subfamily is dependent on both shared and unique cell surface receptors and Smads...
  27. ncbi A niche maintaining germ line stem cells in the Drosophila ovary
    T Xie
    Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Science 290:328-30. 2000
    ..Our studies implicate one of the somatic cell types, the cap cells, as a key niche component...
  28. ncbi Ectopic activation of Dpp signalling in the male Drosophila germline inhibits germ cell differentiation
    Stephanie M Bunt
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia
    Genesis 39:84-93. 2004
    ..This study examined the effect of stimulating Dpp signalling directly in male germ cells...
  29. ncbi Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila
    Jose Bessa
    Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide Consejo Superior de Investigaciones Científicas, Seville, 41013, Spain
    Development 132:5011-20. 2005
    ..at least in part, by allowing the activation of eye specification genes by the wingless (wg) and decapentaplegic (dpp) signaling pathways...
  30. pmc A Drosophila resource of transgenic RNAi lines for neurogenetics
    Jian Quan Ni
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA
    Genetics 182:1089-100. 2009
    ....
  31. pmc Self-maintained escort cells form a germline stem cell differentiation niche
    Daniel Kirilly
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 138:5087-97. 2011
    ..disruption of long EC cellular processes and the accumulation of ill-differentiated single germ cells by increasing BMP signaling activity outside the GSC niche, and also causes gradual EC loss...
  32. ncbi Drosophila Dpp signaling is mediated by the punt gene product: a dual ligand-binding type II receptor of the TGF beta receptor family
    A Letsou
    Department of Human Genetics, University of Utah, Salt Lake City 84112
    Cell 80:899-908. 1995
    ..tkv) genes encode type I receptors that mediate signaling by decapentaplegic (dpp), a member of the bone morphogenetic protein (BMP) subgroup of TGF beta-type factors...
  33. ncbi A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci
    Ping Dai
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Dev Cell 4:917-28. 2003
    ..Thus, Debra defines the border of the Hh-responsive region in the A compartment by inducing the lysosomal degradation of Ci...
  34. pmc Hox control of organ size by regulation of morphogen production and mobility
    Michael A Crickmore
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 313:63-8. 2006
    ..Ubx controls haltere size by restricting both the transcription and the mobility of the morphogen Decapentaplegic (Dpp). Ubx restricts Dpp's distribution in the haltere by increasing the amounts of the Dpp receptor, thickveins...
  35. doi Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels
    Gerald Schwank
    Institut fur Molekularbiologie, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Development 135:4003-13. 2008
    ..we use the model system of the Drosophila wing imaginal disc to address how the patterning signal Decapentaplegic (Dpp) regulates cell proliferation...
  36. ncbi An extensive 3' cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-beta family in Drosophila
    R K Blackman
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138 2097
    Development 111:657-66. 1991
    The decapentaplegic (dpp) gene in Drosophila melanogaster encodes a TGF-beta-like signalling molecule that is expressed in a complex and changing pattern during development...
  37. pmc The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway
    Y C Su
    Department of Pharmacology, New York University Medical Center, Skirball Institute of Biomolecular Medicine, New York, New York 10016 USA
    Genes Dev 12:2371-80. 1998
    ..functions by phosphorylating and activating DJun, which in turn induces the transcription of decapentaplegic (dpp)...
  38. ncbi Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent
    J Curtiss
    Developmental Biology Programme, EMBL, Meyerhofstrasse 1, Germany
    Development 127:1325-36. 2000
    The Drosophila signaling factor decapentaplegic (dpp) mediates the effects of hedgehog (hh) in tissue patterning by regulating the expression of tissue-specific genes...
  39. ncbi Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
    Y Nakano
    MRC Intercellular Signalling Group, Centre for Developmental Genetics, University School of Medicine and Biomedical Science, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Mech Dev 121:507-18. 2004
    ..We further demonstrate that Smo accumulation is likely to be a cause, rather than a consequence, of Hh signal transduction...
  40. ncbi Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila
    Ainhoa Pérez-Garijo
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Development 131:5591-8. 2004
    ..cell proliferation, invasion of compartments and persistent misexpression of the wingless (wg) and decapentaplegic (dpp) signalling genes...
  41. ncbi Male and female Drosophila germline stem cells: two versions of immortality
    Margaret T Fuller
    Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 316:402-4. 2007
    ..Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production...
  42. doi Type IV collagens regulate BMP signalling in Drosophila
    Xiaomeng Wang
    Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Nature 455:72-7. 2008
    ..and invertebrate embryos is mediated by a conserved system of secreted proteins that establishes a bone morphogenetic protein (BMP) gradient...
  43. ncbi An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo
    K A Wharton
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138
    Development 117:807-22. 1993
    decapentaplegic (dpp) is a zygotically expressed gene encoding a TGF-beta-related ligand that is necessary for dorsal-ventral patterning in the Drosophila embryo...
  44. ncbi A gene complex acting downstream of dpp in Drosophila wing morphogenesis
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Nature 381:421-4. 1996
    Localized expression of the transforming growth factor-beta (TGF-beta) homologue decapentaplegic (dpp) is crucial for Drosophila wing development...
  45. ncbi Compartments and appendage development in Drosophila
    S S Blair
    Department of Zoology, University of Wisconsin, Madison 53706, USA
    Bioessays 17:299-309. 1995
    ..Thus, compartments can act as organizing centers for patterning within compartments. Evidence for non-compartmental patterning mechanisms will also be discussed...
  46. ncbi Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    J Jiang
    Howard Hughes Medical Institute, Department of Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 391:493-6. 1998
    ....
  47. ncbi Pointed regulates an eye-specific transcriptional enhancer in the Drosophila hedgehog gene, which is required for the movement of the morphogenetic furrow
    Edward M Rogers
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 132:4833-43. 2005
    ..Recently, others have shown that this same enhancer also requires the eye determining transcription factor Sine oculis (So). We discuss these data in terms of a model for a combinatorial code of furrow movement...
  48. pmc Genetic regulation of patterned tubular branching in Drosophila
    E Hatton-Ellis
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Proc Natl Acad Sci U S A 104:169-74. 2007
    ..We show that patterning of the tubule primordium into two distinct pairs is critical for the eversion of tubule branches, as well as for their asymmetric morphogenesis...
  49. ncbi Notch signaling controls germline stem cell niche formation in the Drosophila ovary
    Xiaoqing Song
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 134:1071-80. 2007
    ..located away from their normal location can still sufficiently sustain GSC self-renewal by maintaining high local BMP signaling and repressing bam as in normal GSCs...
  50. pmc Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins
    K A Wharton
    Department of Cellular, Harvard University, Cambridge, MA 02138
    Proc Natl Acad Sci U S A 88:9214-8. 1991
    ..proteins 5, 6, and 7) than to its only Drosophila relative, the protein product of the decapentaplegic (dpp) gene...
  51. pmc Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo
    R D St Johnston
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
    EMBO J 6:2785-91. 1987
    The decapentaplegic gene of Drosophila melanogaster (dpp) is related to the TGF-beta family of mammalian growth factors...
  52. ncbi Functional dominance among Hox genes: repression dominates activation in the regulation of Dpp
    M Capovilla
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Development 125:4949-57. 1998
    ..We use dpp674, a visceral mesoderm-specific enhancer of decapentaplegic (dpp), to investigate functional dominance among Hox genes molecularly...
  53. ncbi Cell proliferation, survival, and death in the Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Semin Cell Dev Biol 12:499-507. 2001
    ..Reiterated episodes of cell death also contribute to precise regulation of retinal cell number. The EGF receptor homolog has multiple roles in retinal proliferation and survival...
  54. ncbi Gata factor Pannier is required to establish competence for heart progenitor formation
    Susan L Klinedinst
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 130:3027-38. 2003
    Inductive signaling is of pivotal importance for developmental patterns to form. In Drosophila, the transfer of TGFbeta (Dpp) and Wnt (Wg) signaling information from the ectoderm to the underlying mesoderm induces cardiac-specific ..
  55. ncbi Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund
    Kartik S Pappu
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 132:2895-905. 2005
    ..analyses suggest that the 3' eye enhancer is synergistically activated by a combination of eya, so and dpp signaling, and only indirectly activated by ey, whereas the 5' eye enhancer is primarily regulated by ey, acting in ..
  56. pmc Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation
    Shian Jang Yan
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Syst Biol 5:278. 2009
    ..Here we explore the dynamics and function of pathway coordination between the EGFR and DPP pathways during Drosophila wing-vein differentiation...
  57. pmc Sequential phosphorylation of smoothened transduces graded hedgehog signaling
    Ying Su
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Sci Signal 4:ra43. 2011
    ....
  58. ncbi Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene
    V Francois
    Department of Biology, University of California San Diego, La Jolla 92093
    Genes Dev 8:2602-16. 1994
    ..b>dpp, a key gene in this group, encodes a TGF-beta-like product (Dpp) that has been proposed to function as a morphogen ..
  59. ncbi Local inhibition and long-range enhancement of Dpp signal transduction by Sog
    H L Ashe
    Department of Molecular and Cellular Biology, University of California, Berkeley 94720, USA
    Nature 398:427-31. 1999
    ..A gradient of Decapentaplegic (Dpp) activity subdivides the dorsal ectoderm of the Drosophila embryo into amnioserosa and dorsal epidermis...
  60. ncbi The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
    V Martin
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, E 28049, Madrid, Spain
    Curr Biol 11:601-7. 2001
    ..In addition, we show that Ptc(SSD) preferentially accumulates in endosomes of the endocytic compartment. All these results suggest a role of the SSD of Ptc in mediating the vesicular trafficking of Ptc to regulate Smo activity...
  61. doi Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis
    Armel Gallet
    Institut Biologie du Développement et Cancer IBDC, Universite de Nice Sophia Antipolis, UMR 6543 CNRS, Centre de Biochimie, Parc Valrose, 06108 Nice Cedex 2, France
    Dev Cell 14:712-25. 2008
    ..Thus, Dlp endocytosis is a common regulatory mechanism of both Hh and Wg morphogen action...
  62. ncbi Molecular organization of the decapentaplegic gene in Drosophila melanogaster
    R D St Johnston
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138 2097
    Genes Dev 4:1114-27. 1990
    The decapentaplegic (dpp) locus of Drosophila melanogaster is a greater than 55 kb genetic unit required for proper pattern formation during the embryonic and imaginal development of the organism...
  63. ncbi Anti-neural-inhibition: a conserved mechanism for neural induction
    E Bier
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093 0349, USA
    Cell 89:681-4. 1997
  64. ncbi Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila
    R Chen
    Departments of Pathology, Molecular and Human Genetics and Ophthalmology, and Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 126:935-43. 1999
    ..These results suggest a mechanism by which a general patterning signal such as Decapentaplegic cooperates reiteratively with tissue-specific factors to determine distinct cell fates during development...
  65. ncbi [Dorsal closure in Drosophila. A genetic model for wound healing?]
    F Agnes
    Centre de Biologie du Developpement, UMR 5547, Toulouse, France
    C R Acad Sci III 322:5-13. 1999
    ..pathway in the leading edge cells and modification of cell adhesiveness, probably dependent upon activation of the Dpp (TGF-beta) pathway. Coupling of the JNK and TGF-beta pathways is essential...
  66. ncbi Dpp gradient formation in the Drosophila wing imaginal disc
    A A Teleman
    European Molecular Biology Laboratory Meyerhofstr 1 69117, Heidelberg, Germany
    Cell 103:971-80. 2000
    The secreted signaling protein Dpp acts as a morphogen to pattern the anterior-posterior axis of the Drosophila wing...
  67. ncbi Selector and signalling molecules cooperate in organ patterning
    Jennifer Curtiss
    Department of Molecular, Cell and Developmental Biology, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029, USA
    Nat Cell Biol 4:E48-51. 2002
    ..Such enhancers include autoregulatory enhancers of the selector genes themselves, which drive the refinement of expression patterns of selector genes...
  68. ncbi Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary
    Xiaoqing Song
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 131:1353-64. 2004
    ..The niche for germline stem cells (GSCs) provides a Dpp/Bmp signal, which is essential for GSC maintenance...
  69. pmc Genetic and biochemical definition of the Hedgehog receptor
    Xiaoyan Zheng
    Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 24:57-71. 2010
    ..On the basis of their joint roles in ligand binding, signal transduction, and receptor trafficking, we conclude that Ihog and Ptc together constitute the Drosophila Hh receptor...
  70. ncbi Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
    A Penton
    McArdle Laboratory for Cancer Research, Medical School, University of Wisconsin, Madison 53706
    Cell 78:239-50. 1994
    ..Brk25D binds dpp protein and bone morphogenetic protein 2 with high affinity...
  71. ncbi Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila
    T J Brummel
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717
    Cell 78:251-61. 1994
    The dpp/BMP family of TGF beta-related factors controls numerous events in pattern formation and morphogenesis. How these polypeptide signals are received and transduced by target cells is largely unknown...
  72. ncbi Binding sites for transcription factor NTF-1/Elf-1 contribute to the ventral repression of decapentaplegic
    J D Huang
    Department of Chemistry and Biochemistry, University of California, Los Angeles 90095, USA
    Genes Dev 9:3177-89. 1995
    ..We have identified a corepression element in decapentaplegic (dpp), a zygotically active gene that is repressed by the Dorsal morphogen...
  73. ncbi Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing
    R Burke
    Zoologisches Institut, Universitat Zurich, Switzerland
    Development 122:2261-9. 1996
    The mammalian growth factor TGFbeta negatively regulates cell proliferation in various systems. Here we provide evidence that another TGFbeta superfamily member, Drosophila Decapentaplegic (Dpp), stimulates cell proliferation...
  74. ncbi Morphogenetic apoptosis: a mechanism for correcting discontinuities in morphogen gradients
    Takashi Adachi-Yamada
    Department of Sciences for Natural Environment, Faculty of Human Development, Kobe University, Japan
    Dev Biol 251:74-90. 2002
    Smooth gradients of the morphogens Hh, Dpp, and Wg are required for proper development of Drosophila imaginal discs...
  75. ncbi Embryonic enhancers in the dpp disk region regulate a second round of Dpp signaling from the dorsal ectoderm to the mesoderm that represses Zfh-1 expression in a subset of pericardial cells
    A N Johnson
    Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
    Dev Biol 262:137-51. 2003
    During germ band elongation, widespread decapentaplegic (dpp) expression in the dorsal ectoderm patterns the underlying mesoderm. These Dpp signals specify cardial and pericardial cell fates in the developing heart...
  76. ncbi Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo
    Osamu Shimmi
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cell 120:873-86. 2005
    Patterning the dorsal surface of the Drosophila blastoderm embryo requires Decapentaplegic (Dpp) and Screw (Scw), two BMP family members...
  77. pmc Planar cell polarity: one or two pathways?
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nat Rev Genet 8:555-63. 2007
    ..We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field...
  78. pmc Raw mediates antagonism of AP-1 activity in Drosophila
    Katherine L Bates
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Genetics 178:1989-2002. 2008
    ....
  79. ncbi A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family
    R W Padgett
    Nature 325:81-4. 1987
    The decapentaplegic gene complex (DPP-C) has been implicated in several events in pattern formation during Drosophila development. During embryogenesis, the DPP-C participates in the establishment of dorsal-ventral specification...
  80. ncbi Transducing the Dpp morphogen gradient in the wing of Drosophila: regulation of Dpp targets by brinker
    G Campbell
    Department of Genetics and Development, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 96:553-62. 1999
    Dpp, a TGFbeta, organizes pattern in the Drosophila wing by acting as a graded morphogen, activating different targets above distinct threshold concentrations...
  81. pmc Transcriptional control by the TGF-beta/Smad signaling system
    J Massague
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    EMBO J 19:1745-54. 2000
  82. ncbi Schnurri mediates Dpp-dependent repression of brinker transcription
    T Marty
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Nat Cell Biol 2:745-9. 2000
    Signalling by Decapentaplegic (Dpp), a member of the TGFbeta superfamily of signalling molecules, controls many aspects of Drosophila development by activating and repressing target genes...
  83. ncbi Regulation of cell proliferation by a morphogen gradient
    Dragana Rogulja
    Howard Hughes Medical Institute, USA
    Cell 123:449-61. 2005
    ..The Decapentaplegic (DPP) morphogen controls growth in the Drosophila wing, but the slope of the DPP activity gradient has not been shown to ..
  84. pmc Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings
    J Capdevila
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Spain
    EMBO J 13:4459-68. 1994
    In the wing imaginal disc, the decapentaplegic (dpp) gene is expressed in a stripe of anterior cells near the anterior-posterior compartment boundary, and it is required solely in these cells for the entire disc to develop...
  85. ncbi msh may play a conserved role in dorsoventral patterning of the neuroectoderm and mesoderm
    M D'Alessio
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 58:217-31. 1996
    ..This expression is under the control of dorsoventral axis-determination genes and depends on dpp-mediated repression in the dorsal half of the embryo and on fib-(EGF-) mediated repression ventrally...
  86. ncbi Induction of Drosophila eye development by decapentaplegic
    F Pignoni
    Howard Hughes Medical Institute, The School of Medicine, University of California, Los Angeles 90095, USA
    Development 124:271-8. 1997
    The Drosophila decapentaplegic (dpp) gene, encoding a secreted protein of the transforming growth factor-beta (TGF-beta) superfamily, controls proliferation and patterning in diverse tissues, including the eye imaginal disc...
  87. ncbi Shaggy and dishevelled exert opposite effects on Wingless and Decapentaplegic expression and on positional identity in imaginal discs
    T R Heslip
    Developmental Biology Center and Department of Developmental and Cell Biology, University of California Irvine, 92697, USA
    Development 124:1069-78. 1997
    The finding that Wingless (WG) and Decapentaplegic (DPP) suppress each others transcription provides a mechanism for creating developmental territories in fields of cells. Here, we address the mechanism of that antagonism...
  88. ncbi Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses
    R G Wisotzkey
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 125:1433-45. 1998
    Mothers against dpp (Mad) mediates Decapentaplegic (DPP) signaling throughout Drosophila development. Here we demonstrate that Medea encodes a MAD-related protein that functions in DPP signaling...
  89. ncbi TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing
    O Khalsa
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Development 125:2723-34. 1998
    ..One group of such proteins is the TGF-beta/BMP class of related signaling molecules...
  90. ncbi decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc
    D J Hazelett
    Skirball Institute for Biomolecular Medicine and Department of Cell Biology, NYU Medical Center, New York, NY 10016, USA
    Development 125:3741-51. 1998
    ..These results provide a link between the early specification and later differentiation of the eye disc...
  91. pmc A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells
    H Nakagoshi
    Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Genes Dev 12:2724-34. 1998
    ..During midgut development in Drosophila, secreted molecules of Decapentaplegic (Dpp) and Wingless (Wg) establish unique transcriptional regulation within target cells to specify the resultant cell ..
  92. ncbi Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila
    T E Haerry
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Development 125:3977-87. 1998
    In Drosophila wing discs, a morphogen gradient of DPP has been proposed to determine the transcriptional response thresholds of the downstream genes sal and omb...
  93. ncbi The vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Development 126:913-25. 1999
    ..These results lead us to propose a general role for Wingless during development in which it stabilizes cell fate decisions that have been implemented by other molecules...
  94. ncbi TGF-beta family signal transduction in Drosophila development: from Mad to Smads
    L A Raftery
    Cutaneous Biology Research Center, Massachusetts General Hospital Harvard Medical School, Building 149 13th Street, Charlestown, Massachusetts, 02129, USA
    Dev Biol 210:251-68. 1999
    ..Genetic studies in Drosophila are now expanding to include multiple BMP ligands and receptors and have uncovered activities not explained by the current signal transduction model...
  95. ncbi Regeneration in insects
    J L Marsh
    Developmental Biology Center and Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, 92697, USA
    Semin Cell Dev Biol 10:365-75. 1999
    ..Each of the regulatory networks could themselves serve as the subject of a detailed review and that is beyond the scope of this discussion. Here we will focus on the interplay between the regulatory networks in patterning the tissue...
  96. ncbi Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway
    S Greenwood
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Development 126:5795-808. 1999
    ..The first signal, Decapentaplegic (Dpp), acts at long range on undifferentiated cells anterior to the furrow, causing them to enter a 'pre-proneural' ..
  97. ncbi Mechanisms of size control
    C J Potter
    Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536 0812, USA
    Curr Opin Genet Dev 11:279-86. 2001
    ..The mechanisms of organ size control could also be critical targets for evolutionary events or disease processes such as tumorigenesis...
  98. pmc biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila
    S Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 15:2900-15. 2001
    ..biniou expression is activated in the trunk visceral mesoderm primordia downstream of dpp, tinman, and bagpipe and is maintained in all types of developing gut muscles...
  99. ncbi Dally regulates Dpp morphogen gradient formation in the Drosophila wing
    Momoko Fujise
    Department of Biology, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
    Development 130:1515-22. 2003
    Decapentaplegic (Dpp), a Drosophila TGF beta/bone morphogenetic protein homolog, functions as a morphogen to specify cell fate along the anteroposterior axis of the wing...
  100. pmc Ectopic expression of inhibitors of protein phosphatase type 1 (PP1) can be used to analyze roles of PP1 in Drosophila development
    Daimark Bennett
    Department of Zoology, Oxford University, Oxford OX1 3PS, United Kingdom
    Genetics 164:235-45. 2003
    ..PP1 mutants enhance the wing overgrowth phenotype caused by ectopic expression of the type II TGF beta superfamily signaling receptor Punt...
  101. ncbi Deciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development
    Weimin Fu
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 130:5229-39. 2003
    ..Hedgehog (Hh), Decapentaplegic (Dpp) and Notch (N) signaling all contribute...

Research Grants62

  1. Transgenic analysis of Smad tumor suppressor genes
    Stuart Newfeld; Fiscal Year: 2006
    ..This knowledge can be used to determine if Smad proteins should be exploited as anti-cancer drug discovery targets. ..
  2. Analysis of BMP-4 activity in Cleavage mutant mice
    Jan Christian; Fiscal Year: 2007
    ..allows for subsequent cleavage at an upstream nonconsensus furin motif within the prodomain, in Xenopus embryos, BMP-4 synthesized from ectopic precursor in which the upstream site is non-cleavable is initially degraded and signals ..
  3. GORDON RESEARCH CONFERENCE ON PROTEOGLYCANS
    ARTHUR LANDER; Fiscal Year: 2002
    ....
  4. TRAINING PROGRAM IN CELLULAR AND MOLECULAR NEUROSCIENCE
    ARTHUR LANDER; Fiscal Year: 2007
    ..Following completion of this program, trainees will be qualified for careers in Neuroscience research and/or teaching in basic science departments and medical schools, or for research careers in non-academic research laboratories. ..
  5. Identification of extrinsic signals in blood formation
    Jan Christian; Fiscal Year: 2006
    ..We have shown that Bone morphogenetic protein (BMP) function is required in ectodermal cells to generate a secondary signal (s) that act across gem ..
  6. Transport and Complexity in Biological Systems
    ARTHUR LANDER; Fiscal Year: 2004
    ..abstract_text> ..
  7. PROTEOGLYCANS AND BRAIN DEVELOPMENT
    ARTHUR LANDER; Fiscal Year: 2004
    ..These studies should provide insights into how an important and poorly understood class of molecules regulates basic developmental processes, particularly in the nervous system. ..
  8. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  9. Nucleocytoplasmic Trafficking of Smads
    Lan Xu; Fiscal Year: 2008
    ..These regulators of subcellular localization potential targets for therapeutic interventions aimed at modulating TGF-beta signaling diseases such as cancer. ..
  10. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2007
    The Bone Morphogenetic Protein (BMP) family of secreted signaling molecules directs the development of multiple organs and tissue types at various stages in embryogenesis, and is implicated in congenital and adult diseases...
  11. Apoptosis Signaling: BH3 to BH123 Proteins
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2008
    ..The knowledge gained would be valuable in modulating the activity of BAX in cancer and in degenerative diseases. ..
  12. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  13. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
    ..Our work in Drosophila on the mechanisms and targets of these regulators' action will provide insight as to the underlying causes of these diseases and will help to reveal potential therapies. ..
  14. Growth-regulatory targets of Drosophila Cyclin D/Cdk4
    BRUCE EDGAR; Fiscal Year: 2007
    ..Some of the identified genes could be useful targets for cancer diagnosis or anti-cancer chemotherapeutics. [unreadable] [unreadable]..
  15. Mechanism of Hedgehog signal transduction
    JOAN HOOPER; Fiscal Year: 2007
    ..Their successful completion would significantly advance our understanding of this fundamental signal transduction pathway and may pinpoint therapeutic targets for Hh-based pathologies. [unreadable] [unreadable] [unreadable]..
  16. A novel Dlg isoform and identification of its interacting proteins
    Kyung Ok Cho; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Analysis of anti-growth properties of processed Follistatin proteins
    THEODOR HAERRY; Fiscal Year: 2007
    ..The final goal of the proposed work is to engineering modified FS proteins with greater anti-growth properties that could be used to combat cancers caused by mutations in TGF-b signaling components. [unreadable] [unreadable] [unreadable]..
  18. Molecular and Genetic Determinants of Alcohol-Induced Apoptosis
    John Abrams; Fiscal Year: 2007
    ..This information, in turn, could lead to improved therapies for pathologies associated with excessive alcohol consumption. [unreadable] [unreadable] [unreadable] [unreadable]..
  19. ESTABLISHMENT OF DPP ACTIVITY GRADIENT IN DROSOPHILA
    EDWIN FERGUSON; Fiscal Year: 2007
    ..provided by applicant): In both arthropods and chordates, an activity gradient of a member of the Bone Morphogenetic Protein family patterns the embryonic dorsal-ventral axis...
  20. HEDGEHOG SIGNALING IN DEVELOPMENT AND DISEASE
    Thomas Kornberg; Fiscal Year: 2009
    ....
  21. Maintenance of Stem Cell Fates in Drosophila
    Edwin L Ferguson; Fiscal Year: 2010
    ..The GSCs are anchored to the cap cells by adherens junctions. Moreover, Bone Morphogenetic Protein (BMP) family members act as intercellular signals necessary for GSC maintenance...
  22. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
    ..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
  23. MOLECULAR AND GENETIC CONTROL OF PROGRAMMED CELL DEATH
    John Abrams; Fiscal Year: 2008
    ..abstract_text> ..
  24. Regulation of Cell Migration by the APC-Microtubule Complex
    William Nelson; Fiscal Year: 2009
    ..abstract_text> ..
  25. SUMO conjugation in cell biology and Development
    Albert J Courey; Fiscal Year: 2010
    ..Consequently, the research proposed here will advance our understanding of human disease. ..
  26. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
  27. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  28. MOLECULAR GENETICS OF EARLY NEUROGENESIS
    Ethan Bier; Fiscal Year: 2010
    ..in both vertebrate and invertebrate model systems which function by blocking signaling mediated by the Bone Morphogenetic Protein (BMP)pathway...
  29. The molecular basis of morphological evolution
    David L Stern; Fiscal Year: 2010
    ..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
  30. THE DROSOPHILA DORSAL AIR SACS, A MODEL SYSTEM FOR LUNG DEVELOPMENT
    Thomas B Kornberg; Fiscal Year: 2010
    ....
  31. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
  32. Universal Determinants of Alcohol - Induced Toxicity
    JOHN MICHAEL ABRAMS; Fiscal Year: 2010
    ..In turn, these insights will expose new opportunities for improved management of disease caused by alcohol and related stressors in humans ..
  33. Regulation of call adhesion in Xenopus
    KEN CHO; Fiscal Year: 2009
    ..As the development of tumors often parallels the process of embryonic development in terms of rapid cell proliferation and extensive cellular movements, our work may provide direct relevance for a better understanding of tumorigenesis. ..
  34. Molecular Genetics of Drosophila MAGUK's
    Peter Bryant; Fiscal Year: 2005
    ..The work will provide a genetic approach to understanding the functions of Dlg and its mammalian homologs, some of which are strongly implicated in a variety of human cancers. ..
  35. IN VIVO ROLE OF PROTEOGLYCANS IN GROWTH FACTOR SIGNALING
    J Marsh; Fiscal Year: 2001
    ..Further, these in vivo studies may help in understanding the basis of some dysmorphologies in humans. ..
  36. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
    ..This research will aid in the prevention of psychiatric illness and the development of therapies for afflicted individuals. ..
  37. SPECTRAL CONFOCAL MICROSCOPE
    Peter Bryant; Fiscal Year: 2002
    ..abstract_text> ..
  38. MOLECULAR MECHANISM OF WINGLESS SIGNALING
    Susan Cumberledge; Fiscal Year: 2002
    ....
  39. MOLECULAR AND GENETIC CONTROL OF PROGRAMMED CELL DEATH
    John Abrams; Fiscal Year: 2003
    ..This information, in turn, may provide novel rationales for the treatment of some human diseases and could offer valuable new targets for drugs that specifically activate or block the apoptosis pathway. ..
  40. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
    ..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..
  41. DETERMINANTS AND WNT SIGNALING IN ORGANIZER FORMATION
    KEN CHO; Fiscal Year: 2003
    ..2) What are the roles of Xtwn-related genes? 3) What Xtwn-related homologs exist from other vertebrates and how is the initial mechanism of axis specification conserved among vertebrates? ..
  42. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..of the Smad family, but recent results have identified an alternative, indirect mechanism by which one TGF-B, Dpp in Drosophila, can control target gene expression: through negative regulation of a repressor of these targets ..
  43. Characterization of a novel TGF-beta signaling component
    THEODOR HAERRY; Fiscal Year: 2004
    ..signal through the same type 1/11receptors and activate both dSMAD1 (MAD), which is primarily activated by DPP, and dSMAD2. However, the two ligands exhibit opposite effects in vivo...
  44. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ....
  45. Analysis of Early Wing Vein Development in Drosophila
    Ethan Bier; Fiscal Year: 2007
    ..Thus, knowledge gained from these studies should have broad applications to understanding vertebrate development as well as offering possible insights into mechanisms of human disease. ..
  46. MOLECULAR BASIS OF DEVELOPMENTAL CELL INTERACTIONS
    J Marsh; Fiscal Year: 2005
    ..Studies during the last period of this project reveal that two key morphogens, wg and dpp, form a self organizing system by suppressing each other's expression and perhaps by autoactivating their own ..
  47. Genetic Analysis of Bacterial Toxins in Drosophia
    Ethan Bier; Fiscal Year: 2005
    ..DN alleles 2-2: Characterize molecular lesion in DN-toxin NOVA alleles 2-3: Confirm that DN-toxin alleles interfere with wild-type toxin gene function 2-4: Determine whether DN-toxin alleles function in mammalian cells ..
  48. Hedgehog Signaling and Sex-lethal Protein Localization
    JAMILA HORABIN; Fiscal Year: 2004
    ..Understanding the Hh signaling pathway and the different processes it regulates will be important to understanding and curing various cancers. ..
  49. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2005
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  50. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  51. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
    ..Since the machinery for Wnt signal transduction is also evolutionarily conserved, understanding tissue specific mechanisms of Wg signaling in flies should have broad relevance to other organisms. ..
  52. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
    ..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
  53. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
  54. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    ..Basic researchers and the pharmaceutical and biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development. [unreadable] [unreadable]..
  55. Activin/Nodal signaling mechanisms in Xenopus
    KEN CHO; Fiscal Year: 2006
    ..Aim 2: To investigate the existence of FoxHi (Fast)-independent activin/nodal signaling. Aim 3: To determine the Smad4-independent activin/nodal signaling ..
  56. Evolution of insect gastrulation
    Matthew Ronshaugen; Fiscal Year: 2006
    ..It is our hope that this will lead to a specific understanding of the evolution of transcriptional regulation and to events that underlie transition of cells toward a migratory state. ..
  57. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. [unreadable] [unreadable]..
  58. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..