dmfn

Summary

Gene Symbol: dmfn
Description: Mitochondrial assembly regulatory factor
Alias: CG3869, CG38869, Dmel\CG3869, MARF, Marf-1, Mfn, Mfn-2, anon-WO0125274.3, dMFN, dMfn, dMfn2, dmfn, marf, mfn, mfn2, CG3869 gene product from transcript CG3869-RD, CG3869-PB, CG3869-PC, CG3869-PD, Marf-PB, Marf-PC, Marf-PD, drosophila mitofusin, mitochondria assembly regulatory factor, mitochondrial assembly, mitochondrial assembly regulatory factor, mitofusin, mitofusin/MARF, regulatory factor
Species: fruit fly

Top Publications

  1. pmc Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster
    Song Liu
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 6:e1001237. 2010
  2. pmc Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk
    Yun Chen
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 111:863-75. 2012
  3. pmc Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants
    Jonathon L Burman
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:10438-43. 2012
  4. pmc PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila
    Kahori Shiba-Fukushima
    Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    PLoS Genet 10:e1004391. 2014
  5. pmc Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria
    Song Liu
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 8:e1002537. 2012
  6. pmc Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance
    Zhihao Wu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:157-62. 2013
  7. pmc The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila
    Yuzuru Imai
    Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    PLoS Genet 6:e1001229. 2010
  8. pmc MARF and Opa1 control mitochondrial and cardiac function in Drosophila
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 108:12-7. 2011
  9. ncbi Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn
    Jennifer J Hwa
    Department of Developmental Biology, Stanford University School of Medicine, CA 94305, USA
    Mech Dev 116:213-6. 2002
  10. pmc Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
    Anil Rana
    Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 110:8638-43. 2013

Research Grants

  1. PHOSPHOLIPASE C AND CARDIAC HYPERTROPHY
    GERALD DORN; Fiscal Year: 2005
  2. Calpains as Mediators of Cardiac Ischemic Injury
    Gerald W Dorn; Fiscal Year: 2010

Scientific Experts

  • Shamik Banerjee
  • Yuzuru Imai
  • GERALD DORN
  • Song Liu
  • Poonam Bhandari
  • Bingwei Lu
  • Ruth E Thomas
  • Angela C Poole
  • Kahori Shiba-Fukushima
  • Nobutaka Hattori
  • Yun Chen
  • Alexander J Whitworth
  • Jeehye Park
  • Seongsoo Lee
  • Hector Sandoval
  • Kyu Sun Lee
  • Moshi Song
  • Zhihao Wu
  • Jonathon L Burman
  • Leo Pallanck
  • Elena Ziviani
  • I Celardo
  • Yongping Zhang
  • Deniz Senyilmaz
  • Víctor López Del Amo
  • Tejas M Gupte
  • Lucy Liu
  • B Khalil
  • Zong Heng Wang
  • Manish Jaiswal
  • Shinya Yamamoto
  • Brett H Graham
  • Ke Zhang
  • Hugo J Bellen
  • Valentina Debattisti
  • Ran Der Hwang
  • Tsuyoshi Inoshita
  • Jina Yun
  • Nam Chul Kim
  • Anil Rana
  • Mamta Rai
  • Victoria S Burchell
  • Anuradha Ratnaparkhi
  • Tomoko Kanao
  • Ryosuke Takahashi
  • Tomoyo Sawada
  • Imke Schmidt
  • Kasturi Mitra
  • BRIAN DUBOFF
  • Raghavendra Nagaraj
  • Deodoro C S G Oliveira
  • William H Eschenbacher
  • Laurie A Andrews
  • M Thomenius
  • Selina Yu
  • Thomas Rival
  • Ming Guo
  • Leo J Pallanck
  • Ling Yang Hao
  • Jongkyeong Chung
  • Hansong Deng
  • Tim Fergestad
  • Xuejun Tian
  • S H Y Loh
  • Wei Liu
  • N Wood
  • Chao Tong
  • A C Costa
  • L M Martins
  • C Jones
  • Xiaocui Zhao
  • Heng Yu Fan
  • Sungun Huh
  • S Lehmann
  • Do Yeon Lee
  • N E Mencacci
  • Xiaoman Liu
  • G R Mallucci
  • Weina Shang
  • Jian Bai
  • Seung Hyun Hong
  • Xiuying Duan
  • Kweon Yu
  • Jessica Hui
  • Sam Virtue
  • Julian L Griffin
  • Chong Yew Tan
  • Aurelio A Teleman
  • M J Cabirol-Pol
  • Federico V Pallardo

Detail Information

Publications49

  1. pmc Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster
    Song Liu
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 6:e1001237. 2010
    ..Our results reveal complex cellular responses to PINK1 inactivation and suggest novel therapeutic strategies through manipulation of the compensatory responses...
  2. pmc Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk
    Yun Chen
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 111:863-75. 2012
    ..b>Mitofusin (Mfn) 1 and 2 mediate mitochondrial outer membrane fusion, whereas Mfn2 but not Mfn1 tethers endoplasmic ..
  3. pmc Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants
    Jonathon L Burman
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:10438-43. 2012
    ..Moreover, our neural purification method provides a foundation to further explore the pathogenesis of Parkinson disease, and to address other neurobiological questions requiring the analysis of defined neural cell types...
  4. pmc PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila
    Kahori Shiba-Fukushima
    Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    PLoS Genet 10:e1004391. 2014
    ....
  5. pmc Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria
    Song Liu
    Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 8:e1002537. 2012
    ..Moreover, the different effects of loss of PINK1 function on Miro protein level in Drosophila and mouse cells may offer one explanation of the distinct phenotypic manifestations of PINK1 mutants in these two species...
  6. pmc Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance
    Zhihao Wu
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:157-62. 2013
    ..Genetically, mTORC2 and Trc act upstream of Parkin. Thus, multiplex kinase signaling is acting between PINK1 and Parkin to regulate MQC, a process highly conserved in mammals...
  7. pmc The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila
    Yuzuru Imai
    Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    PLoS Genet 6:e1001229. 2010
    ..These results suggest that PGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria and, furthermore, that PGAM5 acts between PINK1 and Parkin, or functions independently of Parkin downstream of PINK1...
  8. pmc MARF and Opa1 control mitochondrial and cardiac function in Drosophila
    Gerald W Dorn
    Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 108:12-7. 2011
    ..The role of mitochondrial fusion in functioning of the heart, where mitochondria comprise ≈30% of cardiomyocyte volume and their intermyofilament spatial arrangement with other mitochondria is highly ordered, is unknown...
  9. ncbi Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn
    Jennifer J Hwa
    Department of Developmental Biology, Stanford University School of Medicine, CA 94305, USA
    Mech Dev 116:213-6. 2002
    ..The fuzzy onions (fzo) and Drosophila mitofusin (dmfn) genes, which encode the only Mitofusin homologs in Drosophila are differentially expressed during ..
  10. pmc Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
    Anil Rana
    Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 110:8638-43. 2013
    ..We show that the mitochondrial fusion-promoting factor Drosophila Mitofusin, a Parkin substrate, increases in abundance during aging...
  11. pmc The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway
    Angela C Poole
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e10054. 2010
    ..We report that the steady-state abundance of the mitochondrial fusion-promoting factor Mitofusin (dMfn) is inversely correlated with the activity of PINK1 and Parkin in Drosophila...
  12. pmc Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin
    Elena Ziviani
    Department of Biomedical Sciences, Medical Research Council Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, United Kingdom
    Proc Natl Acad Sci U S A 107:5018-23. 2010
    ..Furthermore, PINK1 and Parkin mediate the ubiquitination of the profusion factor Mfn on the outer surface of mitochondria...
  13. doi The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process
    Jeehye Park
    National Creative Research Initiatives Center for Cell Growth Regulation and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong gu, Taejon 305 701, Republic of Korea
    Biochem Biophys Res Commun 378:518-23. 2009
    ..the regulators of mitochondrial fusion and fission such as Drp1, which promotes mitochondrial fission, and Opa1 or Marf, which induces mitochondrial fusion...
  14. pmc The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
    Hansong Deng
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 105:14503-8. 2008
    ..is maintained by a dynamic balance between the opposing actions of mitochondrial fusion, controlled by Mitofusin (mfn) and Optic atrophy 1 (opa1), and mitochondrial fission, controlled by drp1...
  15. pmc The PINK1/Parkin pathway regulates mitochondrial morphology
    Angela C Poole
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 105:1638-43. 2008
    ..dosage and by heterozygous loss-of-function mutations affecting the mitochondrial fusion-promoting factors OPA1 and Mfn2. Finally, we find that an eye phenotype associated with increased PINK1/Parkin pathway activity is suppressed by ..
  16. doi The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease
    Ran Der Hwang
    Department of Molecular and Cell Biology, University of Connecticut, 354 Mansfield Road, Storrs, CT 06269, USA Department of Allied Health Sciences, University of Connecticut, 358 Mansfield Road, Storrs, CT 06269, USA
    Neurobiol Dis 69:180-91. 2014
    ....
  17. pmc Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin
    Poonam Bhandari
    From the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO P B, M S, Y C, G W D and Department of Biomedical Sciences, University of Montreal, Quebec, Canada Y B
    Circ Res 114:257-65. 2014
    ..Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin and mitophagic quality control in maintaining normal cardiac homeostasis is poorly understood...
  18. pmc Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
    Kyu Sun Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 27:2642-7. 2013
    ..Our results emphasize the importance of mitochondria to N and NSC biology, with important implications for diseases associated with aberrant N signaling. ..
  19. pmc Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion
    Valentina Debattisti
    Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padua, Italy
    J Cell Biol 204:303-12. 2014
    ..dysfunction ameliorates the functional and developmental defects of flies lacking the single Mfn mitochondrial assembly regulatory factor (Marf)...
  20. doi Signaling by Folded gastrulation is modulated by mitochondrial fusion and fission
    Anuradha Ratnaparkhi
    Agharkar Research Institute, Animal Sciences Division, Zoology Group, G G Agarkar Road, Pune 411 004, India
    J Cell Sci 126:5369-76. 2013
    ..The findings presented here show that mitochondria, through regulation of fusion and fission, function as downstream effectors and modulators of Fog signaling and Fog-dependent cell shape change. ..
  21. pmc PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix
    Ruth E Thomas
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 10:e1004279. 2014
    ..Our findings thus suggest that Lon plays an essential role in regulating the PINK1-Parkin pathway by promoting the degradation of PINK1 in the matrix of healthy mitochondria...
  22. pmc MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
    Jina Yun
    Department of Neurology, University of California, Los Angeles, Los Angeles, United States Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, United States
    elife 3:e01958. 2014
    ..The suppression is achieved through the ubiquitin-dependent degradation of Mitofusin, which itself causes PINK1/parkin mutant-like toxicity when overexpressed...
  23. pmc Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration
    Lucy Liu
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 160:177-90. 2015
    ....
  24. doi A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis
    Shamik Banerjee
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India National Center for Biological Sciences, TIFR, GKVK Campus, Bellary Road, Bangalore 560065, India SASTRA University, Tirumalaisamudram, Thanjavur 613402, India Electronic address
    Int J Biochem Cell Biol 54:36-48. 2014
    ..influences mitochondrial morphology through interaction with 'mitochondria-shaping' proteins like Mitochondrial assembly regulatory factor (Marf) and Drosophila Mitofilin (dMitofilin)...
  25. doi Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot-Marie-Tooth neuropathy
    Víctor López Del Amo
    Program of Rare and Genetic Diseases, Centro de Investigacion Principe Felipe, Valencia, Spain Center for Biomedical Network Research on Rare Diseases CIBERER, Valencia, Spain
    Hum Mol Genet 24:21-36. 2015
    ....
  26. pmc Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production
    Hector Sandoval
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States
    elife 3:. 2014
    ..We show that Marf (Mitochondrial associated regulatory factor), is required for mitochondrial fusion and transport in long axons...
  27. pmc Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering
    Kahori Shiba-Fukushima
    Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    PLoS Genet 10:e1004861. 2014
    ....
  28. pmc The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
    Victoria S Burchell
    Department of Molecular Neuroscience, University College London Institute of Neurology, London, UK
    Nat Neurosci 16:1257-65. 2013
    ..with reduced Fbxo7 expression showed deficiencies in translocation of Parkin to mitochondria, ubiquitination of mitofusin 1 and mitophagy...
  29. doi Effect of myonuclear number and mitochondrial fusion on Drosophila indirect flight muscle organization and size
    Mamta Rai
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, Karnataka 560 012, India
    Exp Cell Res 319:2566-77. 2013
    ..Our results establish the organization levels of DLMs and highlight the importance of the appropriate number of nuclei and mitochondrial fusion in determining the overall organization, growth and size of DLMs...
  30. pmc Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects
    Poonam Bhandari
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Mol Cell Cardiol 80:71-80. 2015
    ..in three models of mitochondrial fragmentation in Drosophila cardiomyocytes: Drp1 expression, Opa1 RNAi, and mitofusin MARF RNA1...
  31. pmc Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway
    Raghavendra Nagaraj
    Department of Molecular, Cell, and Developmental Biology, Broad Stem Cell Research Center, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 26:2027-37. 2012
    ..up-regulation of genes that regulate mitochondrial fusion, such as opa1-like (opa1) and mitochondria assembly regulatory factor (Marf), and results in fused mitochondria with dramatic reduction in reactive oxygen species (ROS)..
  32. pmc PINK1-induced mitophagy promotes neuroprotection in Huntington's disease
    B Khalil
    Aix Marseille Universite, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, UMR 7286, 13344 Marseille, France
    Cell Death Dis 6:e1617. 2015
    ..This neuroprotection was Parkin-dependent and required mitochondrial outer membrane proteins, mitofusin and the voltage-dependent anion channel...
  33. pmc Loss of a Clueless-dGRASP complex results in ER stress and blocks Integrin exit from the perinuclear endoplasmic reticulum in Drosophila larval muscle
    Zong Heng Wang
    Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri, Kansas City, MO 64110, USA
    Biol Open 4:636-48. 2015
    ..This, in turn, is essential for integrin subunit αPS2 ER exit in Drosophila larval myofibers...
  34. pmc Mitochondrial Fragmentation Due to Inhibition of Fusion Increases Cyclin B through Mitochondrial Superoxide Radicals
    Tejas M Gupte
    National Centre for Biological Sciences NCBS TIFR, UAS GKVK Campus, Bellary Road, Bangalore, 560 065, Karnataka, India inStem, Institute for Stem Cell Biology and Regenerative Medicine, GKVK Post, Bellary Road, Bangalore, 560 065, Karnataka, India
    PLoS ONE 10:e0126829. 2015
    ..Our results provide an insight into the need for mitofusin-degradation during mitosis and also help in understanding the mechanism by which mitofusins may function as ..
  35. pmc Regulation of mitochondrial morphology and function by stearoylation of TFR1
    Deniz Senyilmaz
    German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Nature 525:124-8. 2015
    ..This leads to reduced ubiquitination of mitofusin via HUWE1, thereby promoting mitochondrial fusion and function...
  36. doi Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis
    Yongping Zhang
    Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou 310058, China
    Mol Cell 61:111-24. 2016
    ..MIGA proteins function downstream of mitofusin and interact with MitoPLD to stabilize MitoPLD and facilitate MitoPLD dimer formation...
  37. pmc Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca(2+) Homeostasis in Neural Stem Cell Development
    Seongsoo Lee
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA BioNanotechnology Research Center, Korea Research Institute of Biotechnology and Bioscience, Daejeon 34141, Korea
    Dev Cell 37:174-89. 2016
    ..Our results elucidate a regulatory mechanism underlying Ca²⁺ mito homeostasis and how its dysregulation may affect NSC metabolism/development and contribute to disease...
  38. pmc DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
    Ling Yang Hao
    Department of Biology, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:9747-52. 2010
    ..These findings link DJ-1, pink1, and parkin to mitochondrial integrity and provide the foundation for therapeutics that link bioenergetics and parkinsonism...
  39. pmc Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease
    I Celardo
    MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK
    Cell Death Dis 7:e2271. 2016
    ..We show that enhanced ER stress signalling in pink1 and parkin mutants is mediated by mitofusin bridges, which occur between defective mitochondria and the ER...
  40. pmc VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations
    Nam Chul Kim
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38120, USA
    Neuron 78:65-80. 2013
    ..Further, VCP and its adaptor Npl4/Ufd1 are required for clearance of damaged mitochondria via the PINK1/Parkin pathway, and this is impaired by pathogenic mutations in VCP...
  41. pmc Two rare human mitofusin 2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology in Drosophila
    William H Eschenbacher
    Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e44296. 2012
    ..Inexplicably, loss of function mutations of mitofusin 2 (Mfn2) specifically affect neurological tissue, causing Charcot Marie Tooth syndrome (CMT) and atypical optic ..
  42. pmc Tau promotes neurodegeneration via DRP1 mislocalization in vivo
    BRIAN DUBOFF
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 75:618-32. 2012
    ..Our results thus identify actin-mediated disruption of mitochondrial dynamics as a direct mechanism of tau toxicity in neurons in vivo...
  43. doi Kinesin heavy chain function in Drosophila glial cells controls neuronal activity
    Imke Schmidt
    Institut fur Neurobiologie, Universitat Munster, D 48149 Munster, Germany
    J Neurosci 32:7466-76. 2012
    ..Our work shows that the role of Khc for neuronal excitability must be considered in the light of its necessity for directed transport in glia...
  44. doi Monophyly, divergence times, and evolution of host plant use inferred from a revised phylogeny of the Drosophila repleta species group
    Deodoro C S G Oliveira
    Departamento de Genética y Microbiología, Universidad Autonoma de Barcelona, Bellaterra BCN 08193, Spain
    Mol Phylogenet Evol 64:533-44. 2012
    ..Concordant with our proposed timing of host use shifts, these dates are consistent with the suggested times when the Opuntioideae originated in South America. We discuss the generally accepted South American origin of the repleta group...
  45. pmc DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis
    Kasturi Mitra
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 197:487-97. 2012
    ..Reintroduction of mitochondrial fission activity or inhibition of the mitochondrial fusion protein Marf-1 in posterior-localized DRP1-null clones reversed the block in Notch-dependent differentiation...
  46. pmc Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death
    M Thomenius
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Death Differ 18:1640-50. 2011
    ..mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf...
  47. pmc Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways
    Thomas Rival
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR 6216 Aix Marseille Universités, F 13288 Marseille, France
    EMBO Rep 12:223-30. 2011
    ..epistatic experiments indicate that PMI shapes the mitochondria through a mechanism that is independent of drp1 and mfn. This shows that mitochondrial networks can be shaped in higher eukaryotes by at least two separate pathways: one ..
  48. pmc Drosophila Porin/VDAC affects mitochondrial morphology
    Jeehye Park
    National Creative Research Initiatives Center for Energy Homeostasis Regulation, Seoul National University, Seoul, Korea
    PLoS ONE 5:e13151. 2010
    ..Collectively, our study showed that loss of Drosophila Porin results in mitochondrial morphological defects and suggested that the defective mitochondrial function by Porin deficiency affects the mitochondrial remodeling process...
  49. pmc Metabolic disruption in Drosophila bang-sensitive seizure mutants
    Tim Fergestad
    Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 173:1357-64. 2006
    ..Our data implicate cellular metabolism in regulating seizure susceptibility and suggest that differential sensitivity of neuronal subtypes to metabolic changes underlies distinct types of seizure activity...

Research Grants2

  1. PHOSPHOLIPASE C AND CARDIAC HYPERTROPHY
    GERALD DORN; Fiscal Year: 2005
    ..abstract_text> ..
  2. Calpains as Mediators of Cardiac Ischemic Injury
    Gerald W Dorn; Fiscal Year: 2010
    ..Collectively, these studies will apply state-of-the-art techniques for in vivo genetic manipulation, microphysiologic analysis, and biochemical assessment to achieve insight into the roles of myocardial calpains in health and disease. ..