Dl

Summary

Gene Symbol: Dl
Description: Delta
Alias: 0495/20, 0926/11, 1053/14, 1119/09, 1304/03, 1423/11, 1440/11, 1485/04, CG3619, CT12133, Dmel\CG3619, E(ls)2, EC3-5, anon-WO0118547.269, delta, delta D1, dmDelta, l(3)05151, l(3)92Ab, l(3)j8C3, CG3619 gene product from transcript CG3619-RA, CG3619-PA, CG3619-PB, CG3619-PC, Dl-PA, Dl-PB, Dl-PC, complementation group 1, delta, overflow
Species: fruit fly

Top Publications

  1. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
  2. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
  3. ncbi Interaction between Wingless and Notch signaling pathways mediated by dishevelled
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 271:1826-32. 1996
  4. ncbi Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling
    N M White
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 127:1681-9. 2000
  5. ncbi Notch signalling and the initiation of neural development in the Drosophila eye
    A Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 128:3889-98. 2001
  6. ncbi Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation
    D Doherty
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724, USA
    Genes Dev 10:421-34. 1996
  7. ncbi A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila
    Isabel L Torres
    The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Dev Cell 5:547-58. 2003
  8. ncbi Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway
    Stefano de Renzis
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 10:257-64. 2006
  9. doi Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe
    Tetsuo Yasugi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Development 137:3193-203. 2010
  10. ncbi Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis
    S S Huppert
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington 47405, USA
    Development 124:3283-91. 1997

Research Grants

Detail Information

Publications140 found, 100 shown here

  1. ncbi Notch signaling: cell fate control and signal integration in development
    S Artavanis-Tsakonas
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 284:770-6. 1999
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis...
  2. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
    ..We find that clones of cells expressing either Notch or its ligands Delta and Serrate in the wing mimic Notch activation at the dorsoventral boundary producing non-autonomous effects on ..
  3. ncbi Interaction between Wingless and Notch signaling pathways mediated by dishevelled
    J D Axelrod
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Science 271:1826-32. 1996
    ..in implementation of the Winglass signal, interacts antagonistically with Notch and one of its known ligands, Delta. A direct physical interaction between Dishevelled and the Notch carboxyl terminus, distal to the cdc10/ankyrin ..
  4. ncbi Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling
    N M White
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 127:1681-9. 2000
    ..Our results strongly suggest that Atonal regulates signalling and other properties of R8 precursors...
  5. ncbi Notch signalling and the initiation of neural development in the Drosophila eye
    A Baonza
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 128:3889-98. 2001
    ..We provide evidence that Notch activation by its ligand Delta is the second Hh-dependent signal required for neural determination...
  6. ncbi Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation
    D Doherty
    Howard Hughes Medical Institute, University of California, San Francisco, 94143 0724, USA
    Genes Dev 10:421-34. 1996
    ..We provide evidence that Delta, the other known ligand for Notch, is also essential for this process...
  7. ncbi A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila
    Isabel L Torres
    The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Dev Cell 5:547-58. 2003
    ..b>Delta signaling from the older cyst induces the anterior polar follicle cells, the anterior polar cells signal through ..
  8. ncbi Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway
    Stefano de Renzis
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 10:257-64. 2006
    The intracellular trafficking of the Notch ligand Delta plays an important role in the activation of the Notch pathway...
  9. doi Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe
    Tetsuo Yasugi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Development 137:3193-203. 2010
    ..This study also provides new insights into the role of Notch signaling. Expression of the Notch ligand Delta is induced by EGFR, and Notch signaling prolongs the proneural state...
  10. ncbi Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis
    S S Huppert
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington 47405, USA
    Development 124:3283-91. 1997
    b>Delta and Notch are required for partitioning of vein and intervein cell fates within the provein during Drosophila metamorphosis...
  11. ncbi crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
    U Tepass
    Institut für Entwicklungsphysiologie, Universitat zu Koln, Federal Republic of Germany
    Cell 61:787-99. 1990
    ..The structure and the expression pattern of the protein and the phenotype of mutations indicate a function of crumbs during the development of epithelia, possibly for the establishment and/or maintenance of cell polarity...
  12. ncbi Cell proliferation control by Notch signaling in Drosophila development
    M J Go
    Howard Hughes Medical Institute, Department of Cell Biology, Boyer Center for Molecular Medicine, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 125:2031-40. 1998
    ..Vestigial and Wingless, on the contrary, display synergistic effects with Notch signaling, resulting in the stimulation of cell proliferation in imaginal discs...
  13. ncbi Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling
    Kenji Matsuno
    Department of Biological Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Development 129:1049-59. 2002
    ..Therefore, oligomerization mediated by the RING-H2 finger motif is an integral step in the signaling function of Deltex...
  14. ncbi Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells
    Valerie Schaeffer
    Department of Biochemistry, University of Washington, J591 Health Science Building, Seattle, WA 98195 7350, USA
    Curr Biol 14:630-6. 2004
    ..Loss of either Notch function or its ligand Delta (Dl) disrupts the normal transition; this disruption causes mitotic cycling to continue and leads to an ..
  15. ncbi The choice of cell fate in the epidermis of Drosophila
    P Heitzler
    Unité 184 de Biologie Moléculaire, Génie Génétique de l INSERM, Faculte de Medecine, Strasbourg, France
    Cell 64:1083-92. 1991
    ..Failure of this cell communication, as in the mutants Notch (N), Delta, and shaggy, results in most or all of the cells becoming neural...
  16. ncbi Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 122:359-69. 1996
    ..Furthermore other genes identified by their involvement in Notch signaling during neurogenesis, such as Delta and Suppressor of Hairless, also participate in Notch function at the dorsoventral boundary...
  17. ncbi The R8-photoreceptor equivalence group in Drosophila: fate choice precedes regulated Delta transcription and is independent of Notch gene dose
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA
    Mech Dev 74:3-14. 1998
    ..has been suggested that lateral specification of cell fate by Notch signaling depends on feedback on Notch (N) and Delta (Dl) transcription to establish reciprocal distributions of the receptor and its ligand at the protein level...
  18. ncbi UDP-sugar transporter implicated in glycosylation and processing of Notch
    S Goto
    Genetic Strain Research Center, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Nat Cell Biol 3:816-22. 2001
    ..The results suggest that changes in nucleotide-sugar levels can differently affect Wingless and two distinct aspects of Notch signalling...
  19. pmc Regulation of Notch signaling by a novel mechanism involving suppressor of hairless stability and carboxyl terminus-truncated notch
    Cedric S Wesley
    Department of Microbiology and Molecular Genetics, The University of Vermont, Burlington, Vermont 05405, USA
    Mol Cell Biol 23:5581-93. 2003
    ..This mechanism involves SuH-dependent stability of NFull, NFull-dependent accumulation of SuH, stage specific stability of SuH, and NdeltaCterm-dependent loss of SuH and NFull...
  20. ncbi Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development
    Shian Jang Yan
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Development 131:285-98. 2004
    ..Such a mechanism is possibly conserved in the appendage outgrowth of other arthropods and vertebrates...
  21. doi AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursors
    Najate Benhra
    CNRS UMR 6061 Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 2 avenue du Professeur Bernard, 35000 Rennes, France
    Curr Biol 21:87-95. 2011
    ..Because AP-1 does not prevent endocytosis and recycling of the Notch ligand Delta, our data indicate that the DE-cadherin junctional domain may act as a launching pad through which endocytosed ..
  22. pmc Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila
    J F de Celis
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Spain
    Proc Natl Acad Sci U S A 90:4037-41. 1993
    ..Two other transmembrane proteins, encoded by the genes Delta and Serrate, genetically and molecularly behave as Notch ligands...
  23. ncbi A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing
    C J Neumann
    European Molecular Biology Laboratory, Heidelberg, Germany
    Development 122:3477-85. 1996
    ..These results suggest that secreted Wingless protein mediates both long-range and short-range patterning activities of the dorsal/ventral boundary...
  24. ncbi kuzbanian is required cell autonomously during Notch signalling in the Drosophila wing
    Thomas Klein
    Institute for Genetics, University of Cologne, Weyertal 121, 50931 Cologne Germany
    Dev Genes Evol 212:251-5. 2002
    ..that Kuz is required on the signal-emitting side for the generation of an active secreted form of the ligand Delta. In this scenario, kuz should act cell non-autonomously...
  25. pmc Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase
    Keisuke Kamimura
    Dept of Genetics, Cell Biology, and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Cell Biol 166:1069-79. 2004
    ..These findings suggest that Hs3st-B is involved in Notch signaling by affecting stability or intracellular trafficking of Notch protein...
  26. ncbi Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells
    Erin Overstreet
    Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Moffett Molecular Biology Building, 2500 Speedway, Austin, TX 78712, USA
    Development 131:5355-66. 2004
    ..One recent hypothesis is that endocytosis of the ligand Delta by the signaling cells is essential for Notch activation in the receiving cells...
  27. doi Mechanisms of ligand-mediated inhibition in Notch signaling activity in Drosophila
    Ulla Maj Fiuza
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Dev Dyn 239:798-805. 2010
    The transmembrane proteins Delta and Serrate act as ligands for the signaling receptor Notch. In addition to this activating role, Delta and Serrate can also inhibit Notch signaling activity...
  28. pmc Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand
    Il Man Kim
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circ Res 106:1233-43. 2010
    ..Drosophila has been recognized as a model to study human cardiac diseases...
  29. ncbi Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila
    L Seugnet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, Illkirch, CU de Strasbourg, France
    Development 124:2015-25. 1997
    ..of the peripheral nervous system suggested the existence of a regulatory loop between Notch and its ligand Delta within each cell that is under transcriptional control...
  30. ncbi Fringe-dependent notch activation and tramtrack function are required for specification of the polar cells in Drosophila oogenesis
    Cassandra Althauser
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Dev Dyn 232:1013-20. 2005
    ..We now demonstrate that Notch signaling, activated by Delta and transduced by the transcription factor Tramtrack, is involved in the process of refining the prepolar cell ..
  31. pmc Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster
    M Prout
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Genetics 146:275-85. 1997
    ..Mutations in four known genes (blistered, Delta, dumpy and mastermind) were isolated...
  32. ncbi LIN-12/Notch signaling: lessons from worms and flies
    I Greenwald
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032 USA
    Genes Dev 12:1751-62. 1998
  33. ncbi Presenilin is required for activity and nuclear access of Notch in Drosophila
    G Struhl
    Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 398:522-5. 1999
    ..Furthermore, we provide evidence that presenilin is required for the proteolytic release of the intracellular domain from the membrane following activation of Notch by ligand...
  34. ncbi An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila
    V Zecchini
    Department of Zoology University of Cambridge Cambridge, CB2 3EJ, UK
    Curr Biol 9:460-9. 1999
    ..inhibition is implemented by the nuclear protein Suppressor of Hairless (Su(H)) and is triggered by the ligand Delta. Recent results have shown that the interaction between Delta and Notch triggers the cleavage of the intracellular ..
  35. pmc Calcium depletion dissociates and activates heterodimeric notch receptors
    M D Rand
    Massachusetts General Hospital Cancer Center, Department of Cell Biology, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 20:1825-35. 2000
    ..These findings indicate that receptor activation can occur as a consequence of N(EC) dissociation, which relieves inhibition of the intrinsically active N(TM) subunit...
  36. ncbi The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta
    Eric C Lai
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, 545 Life Sciences Addition, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 132:2319-32. 2005
    The receptor Notch and its ligands of the Delta/Serrate/LAG2 (DSL) family are the central components in the Notch pathway, a fundamental cell signaling system that regulates pattern formation during animal development...
  37. doi Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division
    F Coumailleau
    Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Nature 458:1051-5. 2009
    ..fly sensory organ precursors (SOPs): directional signalling is mediated by differential endocytosis of the ligand Delta and the Notch effector Sanpodo in one of the SOP daughters, pIIb...
  38. pmc Neuralized promotes basal to apical transcytosis of delta in epithelial cells
    Najate Benhra
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 6061, Institut de Génétique et Développement de Rennes, Universite de Rennes 1, 35000 Rennes, France
    Mol Biol Cell 21:2078-86. 2010
    ..Activation of Notch requires the ubiquitin-dependent endocytosis of its ligand Delta. How ligand endocytosis in signal-sending cells regulates receptor activation in juxtaposed signal-receiving cells ..
  39. ncbi Numb antagonizes Notch signaling to specify sibling neuron cell fates
    E P Spana
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Neuron 17:21-6. 1996
    ..The Drosophila MP2 precursor divides asymmetrically to generate the dMP2/vMP2 interneurons. Delta-Notch signaling is required to specify vMP2 fate, whereas the localized determinant Numb is segregated into dMP2 ..
  40. ncbi Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo
    J B Skeath
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Development 114:939-46. 1992
    ..It appears that one key function of the neurogenic genes is to silence proneural gene expression within the nonsegregating cells of the initial ectodermal clusters, thereby permitting epidermal development...
  41. pmc Cell autonomy of expression of neurogenic genes of Drosophila melanogaster
    G M Technau
    Proc Natl Acad Sci U S A 84:4500-4. 1987
    ..from donors homozygous for any of several mutant alleles of the neurogenic genes amx, N, bib, mam, neu, and Dl were found to give rise to clones exhibiting a distribution of neural and epidermal histotypes similar to that of ..
  42. ncbi Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye
    M Fanto
    Developmental Biology Programme, EMBL, Heidelberg, Germany
    Nature 397:523-6. 1999
    ..Here we identify Notch and Delta (Dl) as dominant enhancers of the phenotypes produced by overexpression of fz and dishevelled (dsh), which encodes ..
  43. ncbi Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors
    P zur Lage
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 126:3149-57. 1999
    ..by the expression of proneural genes (proneural cluster), and neural fate is refined to single cells by Notch-Delta lateral inhibitory signalling between the cells...
  44. ncbi Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing
    Robert J Major
    Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 132:3823-33. 2005
    ....
  45. ncbi Combinatorial signaling in the specification of primary pigment cells in the Drosophila eye
    Raghavendra Nagaraj
    Department of Molecular, Cell and Developmental Biology, Department of Biological Chemistry, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Development 134:825-31. 2007
    ..use of the sequential integration between the EGFR and Notch pathways to regulate the spatiotemporal expression of Delta in pupal cone cells...
  46. ncbi The function of the neurogenic genes during epithelial development in the Drosophila embryo
    A Y Hartenstein
    Department of Biology, University of California, Los Angeles 90024
    Development 116:1203-20. 1992
    The complex embryonic phenotype of the six neurogenic mutations Notch, mastermind, big brain, Delta, Enhancer of split and neuralized was analyzed by using different antibodies and PlacZ markers, which allowed us to label most of the ..
  47. ncbi Single amino acid substitutions in EGF-like elements of Notch and Delta modify Drosophila development and affect cell adhesion in vitro
    T Lieber
    Laboratory of Genetics, Rockefeller University, New York, New York 10021
    Neuron 9:847-59. 1992
    ..spl, altering eye development, and AxE2, affecting wing and sensilla development, are modified by mutations at Delta. It is shown that two allele-specific suppressors of spl involve single amino acid substitutions in the 4th (..
  48. ncbi Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila
    P Simpson
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg
    Development 109:509-19. 1990
    ..The molecular nature of the protein products of the neurogenic genes is consistent with this idea...
  49. ncbi Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway
    R J Diederich
    Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536 0812
    Development 120:473-81. 1994
    ..In addition to representing a new class of viable Notch allele, this mutation behaves similarly to mutations of deltex and further implicates the ankyrin repeats in Notch function...
  50. ncbi Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch
    E Giniger
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Development 117:431-40. 1993
    ..here, we suggest that growth of the axons constituting the nerve is guided, in part, by the transmembrane proteins Delta and Notch...
  51. ncbi Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development
    P J Kooh
    Howard Hughes Medical Institute, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202
    Development 117:493-507. 1993
    b>Delta and Notch function are required for cell fate specification in numerous tissues during embryonic and postembryonic Drosophila development...
  52. ncbi Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
    T Lieber
    Laboratory of Genetics, Rockefeller University, New York, New York 10021
    Genes Dev 7:1949-65. 1993
    ..b>Delta, mastermind, bigbrain, and neuralized appear to function in elaboration of a signal upstream of Notch...
  53. pmc The scabrous gene encodes a secreted glycoprotein dimer and regulates proneural development in Drosophila eyes
    E C Lee
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 16:1179-88. 1996
    ..We showed that sca mutations, along with conditional alleles of Notch (N) and Delta (Dl), each affected the pattern of cells expressing atonal (ato), the proneural gene required for R8 ..
  54. ncbi Proneural function of neurogenic genes in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Curr Biol 7:122-32. 1997
    ..On this basis, complete elimination of Notch gene function would be expected to cause neural hyperplasia in the eye...
  55. ncbi An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, United Kingdom
    Dev Biol 189:123-34. 1997
    The Serrate and Delta genes of Drosophila encode two transmembrane proteins that act as ligands for the Notch receptor...
  56. ncbi The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta
    D Doherty
    Howard Hughes Medical Institute and the Department of Biochemistry, University of California, San Francisco 94143 0724, USA
    Development 124:3881-93. 1997
    ..Finally, we demonstrate that ectopically expressed big brain acts synergistically with ectopically expressed Delta and Notch, providing the first evidence that big brain may function by augmenting the activity of the Delta-Notch ..
  57. ncbi Requirement for dynamin during Notch signaling in Drosophila neurogenesis
    L Seugnet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    Dev Biol 192:585-98. 1997
    ..However, when wild-type Notch is activated by its ligand Delta, dynamin is required in both signaling and receiving cells for normal singling out of precursors...
  58. ncbi Nuclear access and action of notch in vivo
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 93:649-60. 1998
    ....
  59. ncbi Processing of the notch ligand delta by the metalloprotease Kuzbanian
    H Qi
    Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Science 283:91-4. 1999
    ..Here biochemical and genetic analyses show that the ligand Delta is cleaved on the surface, releasing an extracellular fragment capable of binding to Notch and acting as an ..
  60. ncbi The vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila
    T Klein
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Development 126:913-25. 1999
    ..These results lead us to propose a general role for Wingless during development in which it stabilizes cell fate decisions that have been implemented by other molecules...
  61. ncbi Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye
    M T Cooper
    Department of Anatomy, University of Cambridge, UK
    Nature 397:526-30. 1999
    ..We propose that Fz/Dsh promotes activity of the Notch ligand Delta and inhibits Notch receptor activity in R3, creating a difference in Notch signalling capacity between R3 and R4...
  62. ncbi Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
    Y Ye
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 398:525-9. 1999
    ..They also link the role of presenilin in Notch signalling to its effect on amyloid production in Alzheimer's disease...
  63. ncbi Fringe, Notch, and making developmental boundaries
    K D Irvine
    Waksman Institute, Department of Molecular Biology and Biochemistry, 190 Frelinghuysen Rd, Rutgers University, Piscataway, New Jersey 08854, USA
    Curr Opin Genet Dev 9:434-41. 1999
    ..Lunatic Fringe has been shown to be required for vertebrate somitogenesis, where it appears to act as a crucial link between a molecular clock and the regulation of Notch signaling...
  64. ncbi Notch signaling in the nervous system. Pieces still missing from the puzzle
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Bioessays 22:264-73. 2000
    ..During neural cell fate specification, distributions of Notch protein and of its ligand Delta appear uniform...
  65. ncbi Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye
    Y Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Biol 11:330-8. 2001
    ..During Drosophila eye development, Notch plays an additional role in promoting neural fate independently of Su(H) and E(spl)-C, and this finding suggests an alternative mechanism of Notch signal transduction...
  66. ncbi Neuralized: regulating notch by putting away delta
    H Kramer
    Center for Basic Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Dev Cell 1:725-6. 2001
    Neuralized acts in a subset of Notch-dependent cell fate decisions including lateral inhibition in Drosophila neurogenesis. Three recent papers reveal that Neuralized acts as a ubiquitin ligase and triggers endocytosis of the ligand Delta.
  67. ncbi Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe
    Tetsuya Okajima
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Biol Chem 278:42340-5. 2003
    ..Notch, we assayed the ability of tagged, soluble forms of the Notch extracellular domain to bind to its ligands, Delta and Serrate...
  68. ncbi Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila
    Cyrille De Joussineau
    Laboratoire Dynamique Moléculaire des Interactions Membranaires, CNRS UMR 5539, Université Montpellier II C C 107, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France corrected
    Nature 426:555-9. 2003
    ..Neural competence is restricted to individual sensory organ precursors (SOPs) by Delta/Notch-mediated 'lateral inhibition', whereas other cells in the proneural field adopt an epidermal fate...
  69. ncbi Notch signaling: control of cell communication and cell fate
    Eric C Lai
    Howard Hughes Medical Institute, 545 Life Sciences Addition, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Development 131:965-73. 2004
    ..This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns...
  70. ncbi Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch
    Weidong Wang
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA
    Development 131:5367-80. 2004
    Recent findings suggest that Delta/Serrate/Lag2 (DSL) signals activate Notch by an unprecedented mechanism that requires the ligands to be endocytosed in signal-sending cells to activate the receptor in signal-receiving cells...
  71. ncbi Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system
    Gregory Emery
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 122:763-73. 2005
    ..Numb and Neuralized segregate into the pIIb daughter cell and establish a distinct cell fate by regulating Notch/Delta signaling...
  72. ncbi Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Cell 9:351-63. 2005
    ..A vesicular compartment containing Notch, Sanpodo, and endocytosed Delta accumulates in basal areas of mutant SOPs...
  73. ncbi Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo
    Jennifer Bayraktar
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
    J Cell Sci 119:711-21. 2006
    ..Par-1 also promotes the localization of lateral membrane proteins such as Delta. These activities are important for the further development of cell polarity during gastrulation...
  74. ncbi Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila
    Allison J Bardin
    CNRS UMR 8542, Ecole Normale Superieure, 46, rue d Ulm, 75230 Paris Cedex, France
    Dev Cell 10:245-55. 2006
    ..the E3 ubiquitin ligase Neuralized (Neur) promotes the endocytosis and signaling activity of the ligand Delta (Dl). In this study, we identify proteins of the Bearded (Brd) family as interactors of Neur...
  75. ncbi Tumor suppressors: control of signaling by endocytosis
    Bernd Giebel
    Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Dusseldorf, Moorenstr 5, Geb 14 80, 40225 Dusseldorf, Germany
    Curr Biol 16:R91-2. 2006
    ..These results can be attributed to defective endocytosis of transmembrane proteins that control cell polarity and proliferation, including Crumbs and Notch...
  76. pmc Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis
    Marcus Glittenberg
    Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, UK
    EMBO J 25:4697-706. 2006
    ..The balance of ubiquitinated/unubiquitinated ligand will thus affect the signalling capacity of the cell at several levels...
  77. ncbi The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila
    Ciara M Gallagher
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 11:641-53. 2006
    ..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs...
  78. pmc Differentiation of the Drosophila serotonergic lineage depends on the regulation of Zfh-1 by Notch and Eagle
    Hyung Kook Lee
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell Neurosci 36:47-58. 2007
    ..Our observations on the regulation of Zfh-1 provide a new approach for examining the function of Zfh-1 in motor neurons and larval locomotion...
  79. ncbi Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor
    I Rebay
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06511
    Cell 67:687-99. 1991
    The neurogenic loci Notch and Delta, which both encode EGF-homologous transmembrane proteins, appear to function together in mediating cell-cell communication and have been shown to interact at the cell surface in vitro...
  80. ncbi Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos
    M Lecourtois
    Ecole Normale Supériuer, CNRS ATIPE URA1857, Paris, France
    Curr Biol 8:771-4. 1998
    ..that the intracellular domain of Notch, fused to the DNA-binding domain of Gal4, regulated transcription, in a delta-independent manner...
  81. ncbi Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila
    T L Jacobsen
    Program in Genetics, Cell and Developmental Biology, Department of Biology, Indiana University, Bloomington, Indiana, USA
    Development 125:4531-40. 1998
    We find that ectopic expression of Delta or Serrate in neurons within developing bristle organs is capable of non-autonomously inducing the transformation of the pre-trichogen cell into a tormogen cell in a wide variety of developmental ..
  82. pmc Notch and wingless regulate expression of cuticle patterning genes
    C S Wesley
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 19:5743-58. 1999
    ....
  83. ncbi Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe
    Vladislav M Panin
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey 08854, USA
    J Biol Chem 277:29945-52. 2002
    ..Indeed, O-fucose on mammalian Delta 1 and Jagged1 can be elongated with Manic Fringe in vivo, and Drosophila Delta and Serrate are substrates for ..
  84. ncbi Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye
    Lucy C Firth
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Dev Cell 8:541-51. 2005
    ..These studies identify the specific extracellular signals that pattern the retinal cell cycles and show how differentiation can be uncoupled from cell cycle exit...
  85. ncbi Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila
    Freddy Radtke
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    Bioessays 27:1117-28. 2005
    ..Recent studies indicating that aberrant NOTCH signaling is frequently linked to the induction of T leukemia in humans will also be discussed...
  86. ncbi The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila
    Takashi J Fuwa
    Department of Biological Science and Technology, Tokyo University of Science, 2641 Yamazaki, 278 8510 Noda, Chiba, Japan
    Mol Genet Genomics 275:251-63. 2006
    ..Our epistatic analyses suggested that dx functions downstream of the ligands and upstream of activated Su(H). We also uncovered a novel dx activity that suppressed N signaling downstream of N...
  87. ncbi Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing
    Dolors Ferres-Marco
    Instituto de Neurociencias CSIC UMH, Campus de San Juan, Apartado 18, 03550 Sant Joan, Alicante, Spain
    Nature 439:430-6. 2006
    ..When coupled with overexpression of Delta, deregulation of the expression of Pipsqueak and Lola induces the formation of metastatic tumours...
  88. pmc Dynamical analysis of the regulatory network defining the dorsal-ventral boundary of the Drosophila wing imaginal disc
    Aitor Gonzalez
    Developmental Biology Institute of Marseille Luminy, 13288 Marseille, France
    Genetics 174:1625-34. 2006
    ..Finally, another mutant simulation shows that cut expression might be shifted to late larval stages because of a potential interference with the early signaling process...
  89. pmc Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation
    Jianjun Sun
    Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA
    Dev Cell 12:431-42. 2007
    ..Our studies suggest that Hindsight bridges the two antagonistic pathways, Notch and Hedgehog, in the temporal regulation of follicle-cell proliferation and differentiation...
  90. doi Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine
    Carolina N Perdigoto
    Institut Pasteur, Developmental Biology Department, F 75015 Paris, France
    Development 138:4585-95. 2011
    ..Our work suggests that a commitment requirement for high-level Notch activity safeguards the stem cells from loss through differentiation, revealing a novel role for the importance of Notch signaling levels in this system...
  91. ncbi Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
    R G Fehon
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06511
    Cell 61:523-34. 1990
    ..analyses have raised the possibility of interactions between the gene products of the neurogenic loci Notch and Delta, each of which encodes a transmembrane protein with EGF homology...
  92. ncbi Drosophila eye development: Notch and Delta amplify a neurogenic pattern conferred on the morphogenetic furrow by scabrous
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mech Dev 49:173-89. 1995
    Loss of function mutations of scabrous and conditional alleles of Notch and Delta affect the pattern of morphogenetic furrow development...
  93. ncbi The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands
    X Sun
    Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 122:2465-74. 1996
    We examined the function of the intracellular domains of the two known Drosophila Notch ligands, Delta and Serrate, by expressing wild-type and mutant forms in the developing Drosophila eye under the sevenless promoter...
  94. ncbi The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate
    C A Micchelli
    Department of Zoology, University of Wisconsin, Madison 53706, USA
    Development 124:1485-95. 1997
    ..are flanked on the dorsal and ventral side by domains of cells expressing elevated levels of the Notch ligands Delta and Serrate...
  95. ncbi Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
    K Matsuno
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06536 0812, USA
    Development 124:4265-73. 1997
    ..These signaling activities are independent of the known effector Su(H) and suggest the existence of yet unidentified Notch pathway components...
  96. ncbi Dorsal-ventral signaling in limb development
    K D Irvine
    Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854 8020, USA
    Curr Opin Cell Biol 9:867-76. 1997
    ..to be activated by one ligand, Serrate, while potentiating the ability of Notch to be activated by another ligand, Delta. Recent studies of both Drosophila and vertebrates have also shed new light on the signaling activity of the ..
  97. pmc Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development
    K M Klueg
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Mol Biol Cell 9:1709-23. 1998
    b>Delta functions as a cell nonautonomous membrane-bound ligand that binds to Notch, a cell-autonomous receptor, during cell fate specification...
  98. pmc Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
    S Kidd
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021 6399 USA
    Genes Dev 12:3728-40. 1998
    ..Localization studies in cultured cells and embryos suggest that Su(H) plays a role in this regulation, with the relative levels of Delta, N and Su(H) determining whether a N/Su(H) complex enters the nucleus.
  99. ncbi Evidence for a novel Notch pathway required for muscle precursor selection in Drosophila
    J C Rusconi
    Department of Molecular Biosciences, University of Kansas, Lawrence 66045, USA
    Mech Dev 79:39-50. 1998
    ..These results indicate that Notch acts in two pathways to determine cell fates in mesoderm: the Delta-to-Notch-to-Suppressor of Hairless-to-Enhancer of split signaling pathway previously defined, and a second pathway ..
  100. ncbi Compartment boundaries: at the edge of development
    C Dahmann
    Institut fur Molekularbiologie, Universitat Zurich, Winterthurerstr 190, 8057 Zurich, Switzerland
    Trends Genet 15:320-6. 1999
    ..Here, we describe the exciting progress that has been made recently towards elucidating the mechanisms of boundary formation...
  101. pmc Analysis of notch lacking the carboxyl terminus identified in Drosophila embryos
    C S Wesley
    Department of Genetics, The Rockefeller University, New York, New York 10021, USA
    J Cell Biol 149:683-96. 2000
    ..Notch molecules lacking this region are produced during embryogenesis and form protein complexes with the ligand Delta. Experiments with cultured cells indicate that Delta promotes accumulation of a Notch intracellular fragment ..

Research Grants25

  1. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ....
  2. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
    ..Such knowledge may point to mechanisms that cause brain cells to revert to less differentiated states in brain tumors or degenerate in neurological disorders. ..
  3. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    GERARD L CAMPBELL; Fiscal Year: 2010
    ..Consequently, the proposed studies should provide insights into diseases such as these, potentially leading to improved diagnosis and treatment. ..
  4. THE DROSOPHILA DORSAL AIR SACS, A MODEL SYSTEM FOR LUNG DEVELOPMENT
    Thomas B Kornberg; Fiscal Year: 2010
    ....
  5. HEDGEHOG SIGNALING IN DEVELOPMENT AND DISEASE
    Thomas Kornberg; Fiscal Year: 2009
    ....
  6. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  7. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  8. A novel Dlg isoform and identification of its interacting proteins
    Kyung Ok Cho; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. The enhancer of rudimentary gene
    STUART TSUBOTA; Fiscal Year: 2002
    ..The expression data of e(r) suggest that mutants may be embryonic lethals. If this is the case, the mutants will be analyzed for cellular defects in the embryo that that will help uncover the normal function of e(r). ..
  10. CENTER FOR DEVELOPMENT OF ANTI-SPERM CONTRACEPTIVES
    Paul Primakoff; Fiscal Year: 2006
    ..Thus, we have proposed an expansion of our target list in spermatogenesis, increasing our scope and chances of developing new products for birth control. ..
  11. Understanding cell biology of Delta-Notch interactions
    GERALDINE WEINMASTER; Fiscal Year: 2006
    ..is activated through direct cell-cell interactions that facilitate binding between the transmembrane ligand Delta on a signaling cell and the Notch receptor on a responding cell...
  12. INVESTIGATING A ROLE FOR NOTCH SIGNALING IN ANGIOGENESIS
    GERALDINE WEINMASTER; Fiscal Year: 2001
    ..abstract_text> ..
  13. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  14. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ..relevant targets of Fringe by altering consensus sites for addition of 0-linked fucose within Notch, Serrate, and Delta, and assaying the activity of these mutant proteins in Drosophila...
  15. CONTROL OF TGF-BETA SIGNALING IN DROSOPHILA BY BRINKER
    Gerard Campbell; Fiscal Year: 2004
    ..Consequently, the present research should have direct relevance to our understanding of how defects in TGF-B signaling can lead to disease. ..
  16. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  17. NOTCH SIGNALING IN HEMATOPOIETIC CELLS
    THOMAS KADESCH; Fiscal Year: 2002
    ..Experiments are proposed to characterize signaling through Deltex. ..
  18. NOTCH SIGNALING IN MAMMALIAN CELLS
    GERALDINE WEINMASTER; Fiscal Year: 2002
    ..Together the experiments proposed in this grant will provide new information on the structure/function requirements of Notch-ligand interactions and thereby extend our present understanding of mammalian Notch signaling. ..
  19. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  20. Molecular Mechanisms of Segmentation
    Cordelia Rauskolb; Fiscal Year: 2005
    ..abstract_text> ..
  21. Identification of circadian clock output genes
    Mark Drapeau; Fiscal Year: 2006
    ..Then, some of these genes will be studied molecularly to determine how they are regulated by the central clock. ..
  22. Developing a mouse model to study Notch furin processing
    GERALDINE WEINMASTER; Fiscal Year: 2002
    ....
  23. TRANSCRIPTIONAL DETERMINANTS OF B LYMPHOCYTES
    THOMAS KADESCH; Fiscal Year: 2002
    ....
  24. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..