dj

Summary

Gene Symbol: dj
Description: don juan
Alias: CG1980, Dmel\CG1980, bs02h03.y1, CG1980 gene product from transcript CG1980-RA, CG1980-PA, CG1980-PB, CG1980-PC, Don juan, dj-PA, dj-PB, dj-PC, don-juan
Species: fruit fly

Top Publications

  1. pmc Developmental regulation of transcription by a tissue-specific TAF homolog
    M A Hiller
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Genes Dev 15:1021-30. 2001
  2. ncbi In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF II80 cannonball while translational repression is achieved by distinct elements
    Leonie U Hempel
    Philipps Universitat Marburg, Fachbereich Biologie, Entwicklungsbiologie, Karl von Frisch Strasse 8, 35043 Marburg, Germany
    Dev Dyn 235:1053-64. 2006
  3. pmc Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog
    Catherine C Baker
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Development 134:2863-9. 2007
  4. ncbi fruitless splicing specifies male courtship behavior in Drosophila
    Ebru Demir
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:785-94. 2005
  5. ncbi Testis-specific TAF homologs collaborate to control a tissue-specific transcription program
    Mark Hiller
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Development 131:5297-308. 2004
  6. doi Yuri gagarin is required for actin, tubulin and basal body functions in Drosophila spermatogenesis
    Michael J Texada
    Department of Biochemistry and Cell Biology, MS 140, Rice University, Houston, TX 77005, USA
    J Cell Sci 121:1926-36. 2008
  7. ncbi A flagellar polycystin-2 homolog required for male fertility in Drosophila
    Terry J Watnick
    Department of Medicine, Division of Nephrology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 13:2179-84. 2003
  8. ncbi PKD2 cation channel is required for directional sperm movement and male fertility
    Zhiqian Gao
    Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Biol 13:2175-8. 2003
  9. pmc A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes
    Yun Ding
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    PLoS Genet 6:e1001255. 2010
  10. ncbi A new translational repression element and unusual transcriptional control regulate expression of don juan during Drosophila spermatogenesis
    Nicole Blümer
    FB Biologie, Entwicklungsbiologie, Philipps Universitat Marburg, Karl von Frisch Strasse, 35043 Marburg, Germany
    Mech Dev 110:97-112. 2002

Scientific Experts

  • CHRISTOPHER W BAZINET
  • A Civetta
  • David Morton
  • Kenneth M Fedorka
  • Xin Chen
  • Michael Köttgen
  • Roshan Fatima
  • B Loppin
  • Michael Yaffe
  • Michelle K Smith
  • Yong Yang
  • Jessica A Schoenherr
  • Henry C Chang
  • Xin Zhou
  • Xiangyi Lu
  • Tomotsune Ameku
  • Lior Aram
  • Liat Ravid
  • Renate Renkawitz-Pohl
  • Eli Arama
  • Yoav Politi
  • Sherif El-Sharnouby
  • Wei Cheng
  • Abbas M Abdallah
  • James C Clemens
  • Katja Leser
  • Katie Adolphsen
  • Shuwa Xu
  • Steven Z DeLuca
  • Takashi Ohsako
  • Nabanita Chatterjee
  • Shay Rotkopf
  • Sungjin Moon
  • Chao Wang
  • Xun Huang
  • Haiyang Chen
  • Elizabeth J Rideout
  • Yun Ding
  • So Yeon Kwon
  • Christina Rathke
  • Tom A Hartl
  • Michael J Texada
  • Daniel J Catron
  • Jessica R Von Stetina
  • Erika M Adams
  • Catherine C Baker
  • Leonie U Hempel
  • Chad E Metcalf
  • Margaret T Fuller
  • A Santel
  • Surajit Sarkar
  • Ebru Demir
  • Mark Hiller
  • Ryusuke Niwa
  • Terry J Watnick
  • Smadar Levin-Zaidman
  • Carmel Braverman
  • Zhiqian Gao
  • Tslil Braun
  • Yosef Kaplan
  • Liron Gal
  • Yossi Kalifa
  • Nicole Blümer
  • Zvulun Elazar
  • Y Tony Ip
  • Kushani K Shah
  • Christine Kim
  • Christopher Hogden
  • Robert A H White
  • Juliet Redhouse
  • Zuoshang Xu
  • Madhusudana Rao Chikka
  • Sandra R Schulze
  • Blessing Agunwamba
  • Kyle Mears
  • Paul Schedl
  • Juan S Martinez
  • PATRICK H O'FARRELL
  • M A Hiller
  • Nathan Havko
  • Sara Kevorkian
  • Dietmar Schwarz
  • J Michelle Drennan
  • Hayley Neher
  • Nathaniel Hafer
  • Bridlin Barckmann
  • Mark C Hall
  • Amanda Amell
  • Stephan Awe
  • Toshiro Aigaki

Detail Information

Publications61

  1. pmc Developmental regulation of transcription by a tissue-specific TAF homolog
    M A Hiller
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Genes Dev 15:1021-30. 2001
    ..Our results demonstrate that cell type-specific TAF(II)s play an important role in developmental regulation of gene expression...
  2. ncbi In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF II80 cannonball while translational repression is achieved by distinct elements
    Leonie U Hempel
    Philipps Universitat Marburg, Fachbereich Biologie, Entwicklungsbiologie, Karl von Frisch Strasse 8, 35043 Marburg, Germany
    Dev Dyn 235:1053-64. 2006
    The genes don juan (dj) and don juan like (djl) encode basic proteins expressed in the male germline. Both proteins show a similar expression pattern being localized in the sperm heads during chromatin condensation and along the flagella...
  3. pmc Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog
    Catherine C Baker
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Development 134:2863-9. 2007
    ..Although differentiation markers Dj and Fzo are expressed in late-stage eIF4G2 mutant germ cells, several key steps of spermatid differentiation fail, ..
  4. ncbi fruitless splicing specifies male courtship behavior in Drosophila
    Ebru Demir
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:785-94. 2005
    ..These females direct their courtship toward other females (or males engineered to produce female pheromones). The splicing of a single neuronal gene thus specifies essentially all aspects of a complex innate behavior...
  5. ncbi Testis-specific TAF homologs collaborate to control a tissue-specific transcription program
    Mark Hiller
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Development 131:5297-308. 2004
    ....
  6. doi Yuri gagarin is required for actin, tubulin and basal body functions in Drosophila spermatogenesis
    Michael J Texada
    Department of Biochemistry and Cell Biology, MS 140, Rice University, Houston, TX 77005, USA
    J Cell Sci 121:1926-36. 2008
    ..The structure of the axonemes that grow out from the basal bodies is affected in the yuri mutant, suggesting a possible role for the CA in axoneme formation...
  7. ncbi A flagellar polycystin-2 homolog required for male fertility in Drosophila
    Terry J Watnick
    Department of Medicine, Division of Nephrology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 13:2179-84. 2003
    ..The finding that Amo functions in sperm flagella supports a common and evolutionarily conserved role for polycystin-2 proteins in both motile and nonmotile axonemal-containing structures...
  8. ncbi PKD2 cation channel is required for directional sperm movement and male fertility
    Zhiqian Gao
    Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Curr Biol 13:2175-8. 2003
    ..Our data demonstrate that the Drosophila PKD2 cation channel operates in sperm for directional movement inside the female reproductive tract...
  9. pmc A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes
    Yun Ding
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    PLoS Genet 6:e1001255. 2010
    ....
  10. ncbi A new translational repression element and unusual transcriptional control regulate expression of don juan during Drosophila spermatogenesis
    Nicole Blümer
    FB Biologie, Entwicklungsbiologie, Philipps Universitat Marburg, Karl von Frisch Strasse, 35043 Marburg, Germany
    Mech Dev 110:97-112. 2002
    The Drosophila don juan (dj) gene encodes a basic protein that is expressed solely in the male germline and shows structural similarities to the linker histone H1...
  11. pmc Sequential changes at differentiation gene promoters as they become active in a stem cell lineage
    Xin Chen
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 2685, USA
    Development 138:2441-50. 2011
    ..Together, the action of the tMAC and tTAF cell type-specific chromatin and transcription machinery leads to loss of Polycomb and release of stalled Pol II from the terminal differentiation gene promoters, allowing robust transcription...
  12. ncbi Flagellar mitochondrial association of the male-specific Don Juan protein in Drosophila spermatozoa
    A Santel
    Zoologie Entwicklungsbiologie und Molekulargenetik am Fachbereich Biologie, Philipps Universitat Marburg, Karl von Frisch Strasse, Germany
    J Cell Sci 111:3299-309. 1998
    The Drosophila don juan gene encodes a basic protein (Don Juan protein), which is solely expressed postmeiotically during spermiogenesis in elongated spermatids and in mature sperm...
  13. ncbi The Drosophila don juan (dj) gene encodes a novel sperm specific protein component characterized by an unusual domain of a repetitive amino acid motif
    A Santel
    Philipps Universitat Marburg, Germany
    Mech Dev 64:19-30. 1997
    We identified and characterized the don juan gene (dj) of Drosophila melanogaster...
  14. ncbi Transcriptional and post-transcriptional control mechanisms coordinate the onset of spermatid differentiation with meiosis I in Drosophila
    H White-Cooper
    Department of Developmental Biology, Stanford University School of Medicine, CA 94305 5427, USA
    Development 125:125-34. 1998
    ..We suggest that a gene or genes transcribed under the control of can, mia and sa allow(s) accumulation of twine protein, thus coordinating meiotic division with onset of spermatid differentiation...
  15. ncbi The paternal effect gene ms(3)sneaky is required for sperm activation and the initiation of embryogenesis in Drosophila melanogaster
    K R Fitch
    Department of Genetics, University of Washington, Seattle 98195, USA
    Dev Biol 197:270-82. 1998
    ..We suggest that all of the snky defects can be explained by the failure of the sperm plasma membrane to break down after entry into the egg...
  16. ncbi Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation
    Xin Chen
    Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Science 310:869-72. 2005
    ..Testis TAFs also promoted relocalization of Polycomb Repression Complex 1 components to the nucleolus in spermatocytes, implicating subnuclear architecture in the regulation of terminal differentiation...
  17. pmc The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster
    Shuwa Xu
    Department of Biology, California Institute of Technology, Pasadena, California, United States of America
    PLoS Genet 8:e1003079. 2012
    ..Additionally, analysis of a partial loss of function orb2 mutant suggests that the orb2 differentiation phenotypes are independent of the earlier arrest in meiosis...
  18. pmc Mating-Induced Increase in Germline Stem Cells via the Neuroendocrine System in Female Drosophila
    Tomotsune Ameku
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    PLoS Genet 12:e1006123. 2016
    ..Our study illustrates how female GSC activity is coordinately regulated by the neuroendocrine system to sustain reproductive success in response to mating. ..
  19. pmc The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility
    Katja Leser
    Philipps Universitat Marburg, Fachbereich Biologie, Entwicklungsbiologie, Karl von Frisch Strasse 8, 35043 Marburg, Germany
    Biol Open 1:597-606. 2012
    ..By inhibitor treatment of cultured testis we observed that sub-cellular localisation of tBRD-1 may depend on the acetylation status of primary spermatocytes...
  20. doi Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis
    Abbas M Abdallah
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Dev Biol 378:141-53. 2013
    ..Moreover, Dock forms a complex with Ack, and the localization of Dock in male germ cells depends on its SH2 domain. Together, our results suggest that Ack-dependent tyrosine phosphorylation recruits Dock to promote sperm differentiation...
  21. pmc Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila
    Wei Cheng
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Gene 531:294-300. 2013
    ....
  22. pmc Genome-wide and cell-specific epigenetic analysis challenges the role of polycomb in Drosophila spermatogenesis
    Sherif El-Sharnouby
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 9:e1003842. 2013
    ..The lack of Polycomb at tTAF-dependent spermatogenesis genes in precursor cells argues against a model where Polycomb displacement is the mechanism of spermatogenesis gene activation. ..
  23. doi Paternal mitochondrial destruction after fertilization is mediated by a common endocytic and autophagic pathway in Drosophila
    Yoav Politi
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Cell 29:305-20. 2014
    ..Finally, we show that the ubiquitin ligase Parkin is not involved in PMD, implying a divergence from the autophagic pathway of damaged mitochondria. ..
  24. doi A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation
    Lior Aram
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Cell 37:15-33. 2016
    ....
  25. ncbi Direct visualization of sperm competition and sperm storage in Drosophila
    A Civetta
    Department of Biology, Pennsylvania State University, University Park PA 16802, USA
    Curr Biol 9:841-4. 1999
    ....
  26. ncbi Rickettsia-like mitochondrial motility in Drosophila spermiogenesis
    Christopher Bazinet
    Department of Biological Sciences, St John s University, Jamaica, NY 11439, USA
    Evol Dev 5:379-85. 2003
    ....
  27. pmc Barriers to male transmission of mitochondrial DNA in sperm development
    Steven Z DeLuca
    Department of Biochemistry, UCSF, San Francisco, CA 94110, USA
    Dev Cell 22:660-8. 2012
    ..Our results show that mitochondrial DNA is eliminated during spermatogenesis, thereby removing the capacity of sperm to transmit the mitochondrial genome to the next generation...
  28. pmc Drosophila Dynein intermediate chain gene, Dic61B, is required for spermatogenesis
    Roshan Fatima
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India
    PLoS ONE 6:e27822. 2011
    ..abnormally coiled sperm axonemes causing faulty sperm individualization as revealed by Phalloidin staining in Don Juan-GFP background...
  29. doi The THO complex is required for nucleolar integrity in Drosophila spermatocytes
    Sungjin Moon
    Department of Life Sciences, University of Seoul, Seoul, 130 743, Korea
    Development 138:3835-45. 2011
    ..Taken together, our study suggests that the Drosophila THO complex is necessary for proper spermatogenesis by contribution to the establishment or maintenance of nucleolar integrity rather than by nuclear mRNA export in spermatocytes...
  30. ncbi Sperm of the wasted mutant are wasted when females utilize the stored sperm in Drosophila melanogaster
    Takashi Ohsako
    Drosophila Genetic Resource Center, Kyoto Institute of Technology, Kyoto 616 8354, Japan
    Genes Genet Syst 86:97-108. 2011
    ....
  31. doi The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release
    Shay Rotkopf
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Development 138:2729-39. 2011
    ..A requirement for WASp-based activity in somatic support cells therefore appears to be a universal feature of spermatogenesis...
  32. pmc Drosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channels
    Michael Köttgen
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e20031. 2011
    ..Therefore Amo appears to be a mediator of directed sperm motility in the female reproductive tract but the underlying mechanism is unknown...
  33. pmc Drosophila activated Cdc42 kinase has an anti-apoptotic function
    Jessica A Schoenherr
    Department of Biochemistry, Purdue University, West Lafayette, Indiana, United States of America
    PLoS Genet 8:e1002725. 2012
    ..Our results demonstrate how increased Ack signaling could contribute to cancer when coupled to proliferative signals...
  34. pmc Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis
    Xin Zhou
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907 2054, USA
    Development 138:1111-20. 2011
    ..Our data suggest that Aux participates in forming these Golgi-derived clathrin-positive vesicles and that Aux, therefore, has a role in the secretory pathway...
  35. pmc Neurotransmitter Transporter-Like: a male germline-specific SLC6 transporter required for Drosophila spermiogenesis
    Nabanita Chatterjee
    Department of Biological Sciences, St John s University, Jamaica, New York, United States of America
    PLoS ONE 6:e16275. 2011
    ..The male-sterile phenotype of Ntl mutants may provide a powerful genetic system for studying the function of an SLC6 transporter family in a model organism...
  36. pmc Drosophila sperm motility in the reproductive tract
    Yong Yang
    Institute of Environmental Health Sciences and Department of Biochemistry and Molecular Biology, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA
    Biol Reprod 84:1005-15. 2011
    ..Our analyses here suggest that Pkd2 is required for the sperm to adopt the correct waveform and movement orientation during SR entry. A working model for the sperm's SR entry movement is proposed...
  37. pmc Regulation of flagellar motility by the conserved flagellar protein CG34110/Ccdc135/FAP50
    Yong Yang
    Institute of Environmental Health Sciences and Department of Biochemistry and Molecular Biology, Wayne State University, Detroit, MI 48201, USA
    Mol Biol Cell 22:976-87. 2011
    ..We hypothesize that the CG34110/Ccdc135/FAP50 family of conserved flagellar proteins functions within the axoneme to mediate Pkd2-dependent processes in the sperm flagellum and other motile cilia...
  38. doi Perceived sperm competition intensity influences seminal fluid protein production prior to courtship and mating
    Kenneth M Fedorka
    University of Central Florida, Department of Biology, 4000 Central Florida Blvd, Orlando, FL 32816, USA
    Evolution 65:584-90. 2011
    ..Our data suggest that perceived competition in the pre-mating environment places a significant influence on Sfp allocation, which may be a general trend in promiscuous animal systems with internal fertilization...
  39. doi The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis
    Chao Wang
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Dev Biol 351:146-55. 2011
    ..Together, our study reveals a sterol-dependent, ecdysone-independent mechanism of NPC1 function in Drosophila spermatogenesis...
  40. pmc Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster
    David B Morton
    Department of Integrative Biosciences, Oregon Health and Science University, Portland Oregon 97239, USA
    Genetics 186:159-65. 2010
    ..We also show that Pde1c has a male-specific expression pattern in the CNS with an increased number of Pde1c-expressing neurons in the abdominal ganglion in males...
  41. pmc Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster
    Elizabeth J Rideout
    Faculty of Biomedical and Life Sciences, Integrative and Systems Biology, University of Glasgow, Glasgow, UK
    Nat Neurosci 13:458-66. 2010
    ..We found that disrupting dsx neuronal function had profound effects on male sexual behavior. Furthermore, our results suggest that dsx-positive neurons are involved in pre- to post-copulatory female reproductive behaviors...
  42. pmc Type-I prenyl protease function is required in the male germline of Drosophila melanogaster
    Katie Adolphsen
    Biology Department, Western Washington University, Bellingham, Washington 98225
    G3 (Bethesda) 2:629-42. 2012
    ..We propose that potential targets for the male-specific type I prenyl proteases include proteins involved in the very dramatic cytoskeletal remodeling events required for spermatid maturation...
  43. pmc Complex regulation and multiple developmental functions of misfire, the Drosophila melanogaster ferlin gene
    Michelle K Smith
    Department of Biology and Center for Developmental Biology, University of Washington, Seattle, WA 98195 1800, USA
    BMC Dev Biol 7:21. 2007
    ..Here we analyze the expression and structure of the mfr gene and the consequences of multiple mutations to better understand the developmental function of ferlins...
  44. ncbi An analysis of maleless and histone H4 acetylation in Drosophila melanogaster spermatogenesis
    L Rastelli
    Howard Hughes Medical Institute, Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mech Dev 71:107-17. 1998
    ....
  45. ncbi A trans-activator on the Drosophila Y chromosome regulates gene expression in the male germ line
    P Zhang
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269 2131, USA
    Genetica 109:141-50. 2000
    ..In addition, the Y trans-activator appears to act in a tissue-specific manner, functioning only in the male germ line. We propose that the Y trans-activator plays an important role in regulating gene expression during spermatogenesis...
  46. ncbi Paternal chromosome incorporation into the zygote nucleus is controlled by maternal haploid in Drosophila
    B Loppin
    Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 5534, Universite Claude Bernard Lyon 1, 43, Boulevard du 11 Novembre 1918, Villeurbanne Cedex, 69622, France
    Dev Biol 231:383-96. 2001
    ..The mh phenotype is highly reminiscent of the early developmental defects observed in eggs fertilized by ms(3)K81 mutant males and in eggs produced in incompatible crosses of Drosophila harboring the endosymbiont bacteria Wolbachia...
  47. ncbi The maternal effect mutation sésame affects the formation of the male pronucleus in Drosophila melanogaster
    B Loppin
    Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 5534, Universite Claude Bernard Lyon 1, 43, Boulevard du 11 Novembre 1918, Villeurbanne Cedex, 69622, France
    Dev Biol 222:392-404. 2000
    ..This suggests that the maternally provided sésame(+) function is required for a late stage of sperm chromatin remodeling...
  48. ncbi Sperm competition: defining the rules of engagement
    T L Karr
    Department of Organismal Biology and Anatomy, The University of Chicago, 1027 East 57th Street, Chicago, Illinois 60637, USA
    Curr Biol 9:R787-90. 1999
    ....
  49. ncbi Sperm competition between Drosophila males involves both displacement and incapacitation
    C S Price
    Department of Ecology and Evolution, The University of Chicago, Illinois 60637, USA
    Nature 400:449-52. 1999
    ..Many animal species may have multiple mechanisms of sperm competition like those observed here, and revealing these mechanisms is necessary to understand the genetic and evolutionary basis of second-male sperm precedence in animals...
  50. ncbi The machinery of mitochondrial inheritance and behavior
    M P Yaffe
    Department of Biology, University of California, San Diego, La Jolla, CA 92093 0347, USA
    Science 283:1493-7. 1999
    ..Characterization of the underlying molecular components of this machinery is providing insight into mechanisms regulating mitochondrial morphology and distribution...
  51. ncbi The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility
    Surajit Sarkar
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    J Genet 84:265-81. 2005
    ....
  52. ncbi The Drosophila maternal gene sésame is required for sperm chromatin remodeling at fertilization
    B Loppin
    Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 5534, Universite Claude Bernard Lyon, Villeurbanne, France
    Chromosoma 110:430-40. 2001
    ..The abnormal chromatin organization of the male pronucleus does not prevent the formation of a male pronuclear envelope, which breaks down and reassembles in synchrony with maternally derived nuclei present in the same cytoplasm...
  53. doi Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism
    Haiyang Chen
    Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Hum Mol Genet 19:494-505. 2010
    ..Together our study reveals an indispensable function of pex genes during spermatogenesis and provides a causative link between the phenotypic severity of pex mutants and VLCFA levels...
  54. pmc Alternative splicing of NURF301 generates distinct NURF chromatin remodeling complexes with altered modified histone binding specificities
    So Yeon Kwon
    Institute of Biomedical Research, University of Birmingham, Edgbaston, United Kingdom
    PLoS Genet 5:e1000574. 2009
    ..Our data reveal that variants of the NURF ATP-dependent chromatin remodeling complex that recognize post-translational histone modifications are important regulators of primary spermatocyte differentiation in Drosophila...
  55. pmc Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis
    Tom A Hartl
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America
    PLoS Genet 4:e1000228. 2008
    ..Furthermore, persistence of homologous and heterologous interchromosomal associations lead to anaphase I chromatin bridging and the generation of aneuploid gametes...
  56. pmc alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila
    Jessica R Von Stetina
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 135:3697-706. 2008
    ....
  57. pmc Gene expression disruptions of organism versus organ in Drosophila species hybrids
    Daniel J Catron
    Biology Department, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 3:e3009. 2008
    ....
  58. ncbi Endosymbiotic origins of sex
    Christopher Bazinet
    Department of Biological Sciences, St John s University, Jamaica, NY 11439, USA
    Bioessays 26:558-66. 2004
    ..Through an actin-based motility that drove it from one cell to another, the rickettsial ancestor of mitochondria may have functioned as a primitive transducing particle, the evolutionary progenitor of sperm...
  59. ncbi Rapid evolution and gene-specific patterns of selection for three genes of spermatogenesis in Drosophila
    Alberto Civetta
    Department of Biology, University of Winnipeg, Winnipeg, Manitoba, Canada
    Mol Biol Evol 23:655-62. 2006
    ..playing a role during the sperm developmental pathway in Drosophila at an early (bam), a mid (aly), and a late (dj) stage...
  60. pmc Seminal proteins but not sperm induce morphological changes in the Drosophila melanogaster female reproductive tract during sperm storage
    Erika M Adams
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Insect Physiol 53:319-31. 2007
    ..Our results suggest that timely morphological changes in the female reproductive tract, possibly muscular in nature, may be needed for successful sperm storage, and that Acps from the male are needed in order for these changes to occur...
  61. ncbi DNA binding properties of TAF1 isoforms with two AT-hooks
    Chad E Metcalf
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 281:30015-23. 2006
    ....

Research Grants4

  1. Hotspot for Spermiogenesis Mutations in Drosophila
    Christopher Bazinet; Fiscal Year: 2004
    ..For localization of the sac gene product within developing sperm, antibodies will be generated against synthetic peptides of amino acid sequence unique to sac or bacterially-expressed sac protein. ..
  2. Epigenetic Regulation of Germ Cell Differentiation from a Stem Cell Lineage
    Xin Chen; Fiscal Year: 2008
    ..cellular differentiation during male germ cell development. I am committed to the research in biomedical science, and to the education of future scientists. ..
  3. Regulation and function of cGMP in the nervous system
    David B Morton; Fiscal Year: 2011
    ..Viagra and other pharmacological treatments for erectile disfunction are probably just the tip of the iceberg for compounds that target cGMP mediated processes. ..
  4. MECHANISMS OF MITOCHONDRIAL DIVISION AND INHERITANCE
    Michael Yaffe; Fiscal Year: 2004
    ....