da

Summary

Gene Symbol: da
Description: daughterless
Alias: 5102, CG5102, Dmel\CG5102, SC_DA, bHLHb22, l(2)31Ea, l(2)k08611, CG5102 gene product from transcript CG5102-RB, CG5102-PA, CG5102-PB, CG5102-PC, da-PA, da-PB, da-PC, daughter-less, lethal (2) k08611
Species: fruit fly

Top Publications

  1. pmc Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis
    Ming Ching Wong
    Weill Graduate School of Medical Sciences, Cornell University, New York, NY, USA
    Dev Biol 317:417-29. 2008
  2. ncbi The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila
    M Caudy
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Genes Dev 2:843-52. 1988
  3. ncbi Dosage compensation in Drosophila: the X chromosome binding of MSL-1 and MSL-2 in female embryos is prevented by the early expression of the Sxl gene
    K A McDowell
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Mech Dev 57:113-9. 1996
  4. ncbi The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins
    Hiroshi Tsuda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 122:633-44. 2005
  5. pmc fs (1) Yb is required for ovary follicle cell differentiation in Drosophila melanogaster and has genetic interactions with the Notch group of neurogenic genes
    E Johnson
    Genetics Program, University of Iowa, Iowa City 52242, USA
    Genetics 140:207-17. 1995
  6. ncbi Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae
    M Van Doren
    Department of Biology and Center for Molecular Genetics, University of California San Diego, La Jolla 92093 0322
    Genes Dev 6:2592-605. 1992
  7. ncbi The primary sex determination signal of Drosophila acts at the level of transcription
    L N Keyes
    Department of Biology, Princeton University, New Jersey 08544
    Cell 68:933-43. 1992
  8. pmc Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains
    S M Wainwright
    Department of Zoology, University of Oxford, England
    Mol Cell Biol 12:2475-83. 1992
  9. ncbi The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein
    J Garrell
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Canto Blanco, Spain
    Cell 61:39-48. 1990
  10. ncbi Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster
    D Bopp
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    Genes Dev 5:403-15. 1991

Research Grants

  1. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
  2. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
  3. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
  4. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
  5. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010

Patents

  1. PLASMIDES FOR THE EXPRESSION OF FILAMENTOUS HAEMAGGLUTININ (FHA) AND HOSTS THEREFOR

Scientific Experts

  • Kyoichi Sawamura
  • Lynn M Powell
  • John W Cave
  • Kenneth Cadigan
  • B Giebel
  • Stephen Crews
  • S Campuzano
  • F Huang
  • N E Baker
  • Madina J Sukhanova
  • C S Wesley
  • Eric C Lai
  • Francoise Chanut
  • Trudy F Mackay
  • Matthieu Louis
  • J Modolell
  • C Q Doe
  • Nikolaos Giagtzoglou
  • Christos Delidakis
  • Abhishek Bhattacharya
  • Hamed Jafar-Nejad
  • Ioanna Zarifi
  • Konstantinos A Koumbanakis
  • Tobias Troost
  • Carrie M Spratford
  • Irene Andrade-Zapata
  • Melih Acar
  • Miho Tanaka-Matakatsu
  • Hugo J Bellen
  • Kristina Kux
  • Marianthi Kiparaki
  • Ginnene M Distefano
  • Markus Schneider
  • Thomas Klein
  • Mona Abed
  • Irinka Castanon
  • Afshan Ismat
  • Xin Li
  • Stewart MacArthur
  • Markus Kaspar
  • Alejandra N González
  • Pao Ju Chang
  • Tetsuo Yasugi
  • Ming Ching Wong
  • An Chi Tien
  • Mary K Baylies
  • Hiroshi Tsuda
  • C Cronmiller
  • Xiao Jiang Quan
  • Petra I zur Lage
  • M Caudy
  • S M Parkhurst
  • M Faucheux
  • Vidya Chandrasekaran
  • Julian Ik Tsen Heng
  • Justin P Kumar
  • Antonio Baonza
  • Daniel Borger
  • Benjamin J Frankfort
  • Wei Du
  • John Miller
  • Wei Jen Tang
  • J E Smith
  • Andrew J Gangemi
  • Anastasios Alexiadis
  • I Castanon
  • Daniel R Marenda
  • Ioannis Livadaras
  • Preeti J Khandelwal
  • Evanthia Zacharioudaki
  • E Segev
  • Aleister J Saunders
  • Jeffrey J Delrow
  • Amir Orian
  • Kevin C Barry
  • Susan M Parkhurst
  • Bella Koltun
  • Dorit Kenyagin
  • Taryn M Phippen
  • R Nolo
  • A Baonza
  • Katharina Kirchner
  • Manfred Frasch
  • Q Wei
  • M L Huang
  • Christoph Schaub
  • Dorothea Schultheis
  • Ingolf Reim
  • S E Goulding
  • Brandi P Grondona

Detail Information

Publications113 found, 100 shown here

  1. pmc Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis
    Ming Ching Wong
    Weill Graduate School of Medical Sciences, Cornell University, New York, NY, USA
    Dev Biol 317:417-29. 2008
    ..its dimerization partner: Twi homodimers activate genes necessary for somatic myogenesis, whereas Twi/Daughterless (Da) heterodimers lead to the repression of these genes...
  2. ncbi The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila
    M Caudy
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Genes Dev 2:843-52. 1988
    The daughterless (da) gene is known to have separate maternal and zygotic functions: Maternally supplied daughterless activity is required for proper sex determination and dosage compensation in female embryos, whereas loss of zygotically ..
  3. ncbi Dosage compensation in Drosophila: the X chromosome binding of MSL-1 and MSL-2 in female embryos is prevented by the early expression of the Sxl gene
    K A McDowell
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Mech Dev 57:113-9. 1996
    ....
  4. ncbi The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins
    Hiroshi Tsuda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 122:633-44. 2005
    ..Interestingly, loss of Gfi-1 mimics SCA1 phenotypes in Purkinje cells. These results indicate that the Atx-1/Gfi-1 interaction contributes to the selective Purkinje cell degeneration in SCA1...
  5. pmc fs (1) Yb is required for ovary follicle cell differentiation in Drosophila melanogaster and has genetic interactions with the Notch group of neurogenic genes
    E Johnson
    Genetics Program, University of Iowa, Iowa City 52242, USA
    Genetics 140:207-17. 1995
    ..We propose that fs (1) Yb acts as an ovary-specific factor that determines follicle cell fate...
  6. ncbi Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae
    M Van Doren
    Department of Biology and Center for Molecular Genetics, University of California San Diego, La Jolla 92093 0322
    Genes Dev 6:2592-605. 1992
    ..Our results indicate that emc plays an essential early role in defining territories of bristle-forming potential...
  7. ncbi The primary sex determination signal of Drosophila acts at the level of transcription
    L N Keyes
    Department of Biology, Princeton University, New Jersey 08544
    Cell 68:933-43. 1992
    ..The proteins produced from these early mRNAs then initiate the autoregulatory loop by directing the female-specific processing of transcripts from the late Sxl promoter...
  8. pmc Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domains
    S M Wainwright
    Department of Zoology, University of Oxford, England
    Mol Cell Biol 12:2475-83. 1992
    ..We show that the h protein in Drosophila virilis closely resembles that in D. melanogaster and includes completely conserved bHLH and WRPW domains...
  9. ncbi The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein
    J Garrell
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Canto Blanco, Spain
    Cell 61:39-48. 1990
    ..These and other findings suggest the existence of a network of synergistic and antagonistic interactions, mediated by HLH proteins, that participates in the establishment of the neural fate...
  10. ncbi Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster
    D Bopp
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    Genes Dev 5:403-15. 1991
    ..The onset of Sxl expression in the germ line occurs later than that in the soma...
  11. pmc Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila
    C V Cabrera
    Marie Curie Research Institute, Oxted, Surrey, UK
    EMBO J 10:2965-73. 1991
    The achaete-scute complex (AS-C) and the daughterless (da) genes encode helix-loop-helix proteins which have been shown to interact in vivo and to be required for neurogenesis...
  12. ncbi A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
    C Murre
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 56:777-83. 1989
    ..Remarkable is the stringent conservation of hydrophobic residues present in both helices. We demonstrate that this new motif plays a crucial role in both dimerization and DNA binding...
  13. ncbi Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
    C Murre
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 58:537-44. 1989
    ..A role of E12 and E47 in mammalian development, analogous to that of daughterless in Drosophila, is likely...
  14. ncbi Molecular characterization of daughterless, a Drosophila sex determination gene with multiple roles in development
    C Cronmiller
    Department of Biology, Princeton University, New Jersey 08544 1003
    Genes Dev 2:1666-76. 1988
    The daughterless (da) gene in Drosophila acts both maternally and zygotically to provide essential functions during development...
  15. ncbi The relationship of relative gene dose to the complex phenotype of the daughterless locus in Drosophila
    C Cronmiller
    Department of Biology, Princeton University, NJ 08544
    Dev Genet 7:205-21. 1986
    The daughterless (da) gene provides an essential maternally supplied component for Drosophila sex determination and dosage compensation...
  16. ncbi Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity
    A M Bailey
    Department of Biology, University of California San Diego, La Jolla 92093 0366, USA
    Genes Dev 9:2609-22. 1995
    ..Our results establish Su(H) as a direct regulatory link between N receptor activity and the expression of E(spl)-C genes, extending the known linear structure of the N cell-cell signaling pathway...
  17. ncbi daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
    Development 120:935-45. 1994
    ..genes of the achaete-scute complex AS-C (achaete (ac), scute (sc) and lethal of scute (l'sc)) and daughterless (da). The da protein dimerizes with AS-C products in vitro to form DNA-binding proteins...
  18. ncbi Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
    Z Paroush
    Laboratory of Developmental Genetics, University of Oxford, England
    Cell 79:805-15. 1994
    ....
  19. ncbi The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors
    A P Jarman
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0724, USA
    Development 119:19-29. 1993
    ..asense differs from the other AS-C members in its expression pattern, regulation, mutant phenotype and some DNA-binding properities...
  20. pmc The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain
    A L Fisher
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021, USA
    Mol Cell Biol 16:2670-7. 1996
    ..These results directly demonstrate that Groucho family proteins are active transcriptional corepressors for Hairy-related proteins and are recruited by the 4-amino acid protein-protein interaction domain, WRPW...
  21. pmc A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system
    P Alifragis
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, and Department of Biology, University of Crete, Heraklion, Greece
    Proc Natl Acad Sci U S A 94:13099-104. 1997
    ..fidelity of the system was established by its ability to closely reproduce the already documented interactions among Da, Ac, Sc, and Extramacrochaetae...
  22. ncbi The function of hairy-related bHLH repressor proteins in cell fate decisions
    A Fisher
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York, USA
    Bioessays 20:298-306. 1998
    ..This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis...
  23. ncbi Relationships between extramacrochaetae and Notch signalling in Drosophila wing development
    A Baonza
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Development 127:2383-93. 2000
    ..We propose that at least during vein differentiation and wing margin formation, extramacrochaetae is regulated by Notch and collaborates with other Notch-downstream genes such as Enhancer of split-m(beta)...
  24. ncbi Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development
    I Castanon
    Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Development 128:3145-59. 2001
    ..Moreover, this work provides a paradigm for understanding how the same protein controls a sequence of events within a single lineage...
  25. ncbi Emc, a negative HLH regulator with multiple functions in Drosophila development
    S Campuzano
    Centro de Biologia Molecular Severo Ochoa, Cantoblanco, 28049 Madrid, Spain
    Oncogene 20:8299-307. 2001
    ..However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation...
  26. ncbi A Twist in fate: evolutionary comparison of Twist structure and function
    Irinka Castanon
    Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 287:11-22. 2002
    ..Conserved principles and the molecular mechanisms underlying them are discussed...
  27. ncbi Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless
    Kenneth M Cadigan
    Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, Stanford, California 94305, USA
    Development 129:3393-402. 2002
    ..These results are summarized in a model where daughterless is a major, but probably not the only, target of wingless action in the eye...
  28. ncbi The role of class I HLH genes in neural development--have they been overlooked?
    Julian Ik Tsen Heng
    Brain Development Group, The Howard Florey Institute, University of Melbourne, Parkville VIC 3010, Melbourne Australia
    Bioessays 25:709-16. 2003
    ..This essay supports this possibility, in addition to putting forward the hypothesis that, outside their general dimerisation activity, class I genes have independent roles in regulating neurogenesis...
  29. ncbi EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulation
    Petra I zur Lage
    Division of Biomedical Sciences, Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    Dev Cell 7:687-96. 2004
    ..This exemplifies a simple and general mechanism for regulating the transition from competence to cell fate commitment whereby a cell signal directly targets the autoregulation of a selector gene...
  30. pmc Proneural basic helix-loop-helix proteins and epidermal growth factor receptor signaling coordinately regulate cell type specification and cdk inhibitor expression during development
    Madina J Sukhanova
    Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    Mol Cell Biol 27:2987-96. 2007
    ..transcription factor Pointed (Pnt) and the proneural basic helix-loop-helix proteins Atonal (Ato) and Daughterless (Da)...
  31. doi Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT
    Tetsuo Yasugi
    Laboratory of Pattern Formation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:1471-80. 2008
    ....
  32. doi Negative-feedback regulation of proneural proteins controls the timing of neural precursor division
    Pao Ju Chang
    Department of Life Science, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan 333, Taiwan
    Development 135:3021-30. 2008
    ..As phyl is a direct transcriptional target of Ac and Sc, our data suggest that, in addition to mediating cell cycle arrest, proneural protein initiates a negative-feedback regulation to time the mitotic entry of neural precursors...
  33. doi Klumpfuss is involved in the determination of sensory organ precursors in Drosophila
    Markus Kaspar
    Institute of Genetics, Heinrich Heine University Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Dev Biol 324:177-91. 2008
    ..We present a detailed structure function analysis that identifies functionally important domains within Klu...
  34. pmc The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye
    Abhishek Bhattacharya
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 327:288-300. 2009
    ..A model is proposed in which Extramacrochaetae acts in parallel to or as a feed-forward regulator of the E(spl)-Complex to promote Notch signaling in particular cellular contexts...
  35. pmc A microRNA imparts robustness against environmental fluctuation during development
    Xin Li
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
    Cell 137:273-82. 2009
    ..We suggest that some conserved microRNAs like miR-7 may enter into novel genetic relationships to buffer developmental programs against variation and impart robustness to diverse regulatory networks...
  36. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  37. pmc A network of broadly expressed HLH genes regulates tissue-specific cell fates
    Abhishek Bhattacharya
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 147:881-92. 2011
    ..In Drosophila, a cross-interacting regulatory network links expression of the E protein Daughterless (Da), which heterodimerizes with bHLH proteins to activate them, with expression of the Id protein Extramacrochaetae (..
  38. doi The two Tribolium E(spl) genes show evolutionarily conserved expression and function during embryonic neurogenesis
    Kristina Kux
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas and Department of Biology, University of Crete, Heraklion, Crete, Greece
    Mech Dev 130:207-25. 2013
    ..A number of other activities have been evolutionarily conserved, most notably their ability to interact with proneural proteins Scute and Daughterless...
  39. pmc Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation
    Miho Tanaka-Matakatsu
    Ben May Department for Cancer Research, The University of Chicago, 929 E 57th Street, Chicago, IL 60637, USA
    Dev Biol 392:256-65. 2014
    ..In this manuscript, we show that a linked dimer of Daughterless (Da), the only Drosophila class I bHLH protein, activates Atonal (Ato) expression and retinal neuron differentiation ..
  40. ncbi Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: epidermogenesis or neurogenesis
    J A Campos-Ortega
    Institut für Entwicklungsphysiologie, Universitat zu Koln, Federal Republic of Germany
    Eur J Biochem 190:1-10. 1990
    ....
  41. ncbi daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex
    M Caudy
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143
    Cell 55:1061-7. 1988
    daughterless (da) has multiple functions in Drosophila embryonic development: maternal da activity is necessary for proper sex determination, and zygotic da activity is necessary for formation of the peripheral nervous system...
  42. ncbi The Drosophila sex determination gene daughterless has different functions in the germ line versus the soma
    C Cronmiller
    Cell 48:479-87. 1987
    As a regulator of the female-specific gene Sxl, da+ provides an essential maternal component in the control of sex determination and dosage compensation; nevertheless, neither the maternal nor zygotic phenotypes of the original mutant da ..
  43. ncbi The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during development
    C Cronmiller
    Department of Biology, University of Virginia, Charlottesville 22901
    Mech Dev 42:159-69. 1993
    The daughterless (da) gene in Drosophila functions in the regulation of at least three significant developmental pathways: sex determination, neurogenesis and oogenesis...
  44. ncbi The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes
    U Hinz
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
    Cell 76:77-87. 1994
    ..Finally, the bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition...
  45. ncbi Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila
    S González-Crespo
    Department of Biology, University of California at San Diego, La Jolla 92093 0322
    Genes Dev 7:1703-13. 1993
    ..Evidence is also presented that dl-HLH interactions involve the direct physical association of these proteins in solution mediated by the rel and HLH domains. We discuss the striking parallels in mesoderm formation and sex determination...
  46. ncbi asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation
    M Brand
    Howard Huges Medical Institute, University of California, San Francisco, CA 94143 0724, USA
    Development 119:1-17. 1993
    ..Our studies therefore serve as a cautionary note for the inference of normal gene function based on the gain-of-function phenotype after ectopic expression...
  47. ncbi Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
    R Nolo
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 102:349-62. 2000
    ..Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs...
  48. ncbi Two modes of recruitment of E(spl) repressors onto target genes
    Nikolaos Giagtzoglou
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Greece
    Development 130:259-70. 2003
    ..Irrespective of whether E(spl) are recruited via direct DNA binding or interaction with proneural proteins, the co-repressor Groucho is always needed for target gene repression...
  49. ncbi Role of the Sc C terminus in transcriptional activation and E(spl) repressor recruitment
    Nikolaos Giagtzoglou
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Vasilika Vouton, Heraklion, GR 71110, Greece
    J Biol Chem 280:1299-305. 2005
    ..In vivo, the Sc C-terminal domain is required for E(spl) recruitment in an enhancer context-dependent fashion, suggesting that in some enhancers alternative interaction surfaces can be used to recruit E(spl) proteins...
  50. ncbi Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin
    Hamed Jafar-Nejad
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 133:1683-92. 2006
    ..Our data indicate that transcription factors other than bHLH proteins can also perform the proneural function in the Drosophila peripheral nervous system...
  51. pmc A shared enhancer controls a temporal switch between promoters during Drosophila primary sex determination
    Alejandra N González
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 105:18436-41. 2008
    ....
  52. pmc Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression
    Ioanna Zarifi
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, and Department of Biology, University of Crete, Heraklion, Crete, Greece
    Mol Cell Biol 32:4534-48. 2012
    ..Daughterless (Da) is the sole E protein in Drosophila and is ubiquitously expressed...
  53. ncbi The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes
    M Van Doren
    Department of Biology, University of California San Diego, La Jolla 92093 0322
    Development 113:245-55. 1991
    ..Proteins encoded by the daughterless (da) gene and three genes of the achaete-scute complex (AS-C) act positively in the determination of the sensory organ ..
  54. ncbi daughterless is required for Drosophila photoreceptor cell determination, eye morphogenesis, and cell cycle progression
    N L Brown
    Howard Hughes Medical Institute and Bock Laboratories, Madison, Wisconsin 53706, USA
    Dev Biol 179:65-78. 1996
    ..basic helix-loop-helix (bHLH) transcription factors that dimerize in vitro with another bHLH protein, daughterless (da)...
  55. ncbi Evolution of neural precursor selection: functional divergence of proneural proteins
    Xiao Jiang Quan
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, Belgium
    Development 131:1679-89. 2004
    ..These data suggest an evolutionary divergence in the mechanisms of NPC selection between protostomes and deuterostomes...
  56. ncbi Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling
    A Singson
    Department of Biology, University of California San Diego, La Jolla 92093 0322
    Genes Dev 8:2058-71. 1994
    ..Thus, one of the earliest steps in adult peripheral neurogenesis is the direct activation by proneural proteins of genes involved in restricting the expression of the SOP cell fate...
  57. ncbi Protein-protein interactions among components of the Drosophila primary sex determination signal
    Y Liu
    Department of Biology, Syracuse University, NY 13244, USA
    Mol Gen Genet 248:182-9. 1995
    ..g., deadpan (dpn)], and (3) maternal factors [e.g., daughterless (da)]...
  58. ncbi A genetic screen for elements of the network that regulates neurogenesis in Drosophila
    G Röttgen
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Mol Gen Genet 257:442-51. 1998
    ..Besides mutations in genes expected to modify the phenotype, we have isolated mutations in six genes not known so far to be involved in neurogenesis...
  59. pmc batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor
    M Faucheux
    Laboratoire d Embryologie Moleculaire et Experimentale, Chromatine et Développement, CNRS ESA 8080, Universite Paris Sud, Orsay, France
    Mol Cell Biol 23:1181-95. 2003
    ..Together, our results suggest that batman belongs to a subset of the Polycomb/trithorax group of genes that includes Trithorax-like, whose products are involved in both activation and repression of homeotic genes...
  60. pmc The bHLH factors extramacrochaetae and daughterless control cell cycle in Drosophila imaginal discs through the transcriptional regulation of the Cdc25 phosphatase string
    Irene Andrade-Zapata
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
    PLoS Genet 10:e1004233. 2014
    ..The E protein orthologue Daughterless (Da) and the Id orthologue Extramacrochaetae (Emc) are the only members of these classes of bHLH proteins in Drosophila...
  61. pmc A re-examination of the selection of the sensory organ precursor of the bristle sensilla of Drosophila melanogaster
    Tobias Troost
    Institut fuer Genetik, Heinrich Heine Universitaet Duesseldorf, Duesseldorf, Germany
    PLoS Genet 11:e1004911. 2015
    ..They encode tissue specific bHLH proteins that form functional heterodimers with the bHLH protein Daughterless (Da)...
  62. pmc Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation
    Carrie M Spratford
    Department of Biology, Indiana University, Bloomington, IN 47405, USA Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 142:2058-68. 2015
    ..Notch signaling is devoted to blocking the growth-suppressing activity of the bHLH DNA-binding protein Daughterless (Da)...
  63. pmc HLH54F is required for the specification and migration of longitudinal gut muscle founders from the caudal mesoderm of Drosophila
    Afshan Ismat
    Mount Sinai School of Medicine, Department of Molecular, Cell and Developmental Biology currently Developmental and Regenerative Biology, Box 1020, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 137:3107-17. 2010
    ..We conclude that HLH54F is the earliest specific regulator of CVM development and that it plays a pivotal role in all major aspects of development and differentiation of this largely twist-independent population of mesodermal cells...
  64. pmc Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression
    Mona Abed
    Cancer and Vascular Biology Research Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    EMBO J 30:1289-301. 2011
    ..As Gro/TLE proteins are conserved universal corepressors, this may be a general paradigm used to regulate the Gro/TLE corepressors in other developmental processes...
  65. pmc Drosophila lilliputian is required for proneural gene expression in retinal development
    Ginnene M Distefano
    Department of Biology, Drexel University, Philadelphia, Pennsylvania 19104, USA
    Dev Dyn 241:553-62. 2012
    ..expression of the basic helix-loop-helix (bHLH) proneural transcription factors Atonal (Ato) and Daughterless (Da)...
  66. pmc Evidence for a set of closely linked autosomal genes that interact with sex-chromosome heterochromatin in Drosophila melanogaster
    L Sandler
    Genetics 86:567-82. 1977
    ..The nature of this interaction and possible reasons for the existence of the cluster of autosomal genes are discussed...
  67. ncbi Sex determination and differentiation in invertebrates: Drosophila and Caenorhabditis elegans
    M McKeown
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Curr Opin Cell Biol 4:948-54. 1992
    ..We are now gaining an understanding of the molecular mechanisms governing the largely post-transcriptional regulation of the intermediate steps in these cascades...
  68. ncbi The segmentation gene runt is needed to activate Sex-lethal, a gene that controls sex determination and dosage compensation in Drosophila
    M Torres
    Centro de Investigaciones Biologicas, Madrid, Spain
    Genet Res 59:189-98. 1992
    ..We conclude that runt is needed for the initial step of Sex-lethal activation, but does not have a major role as an X-counting element...
  69. ncbi Calmodulin transcription is limited to the nervous system during Drosophila embryogenesis
    G E Kovalick
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005
    Dev Biol 150:33-46. 1992
    ..The calmodulin transcription pattern is altered in embryos mutant for each of these loci, suggesting that regulation by these genes, either directly or indirectly, is taking place...
  70. ncbi The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal
    J B Duffy
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 5:2176-87. 1991
    ..runt is distinguished from previously identified regulators of Sxl by its nonuniform role and by the absence of an identifiable helix-loop-helix (HLH) motif, indicating that the activation of Sxl is not controlled solely by HLH proteins...
  71. ncbi Specification of cell fate in the developing eye of Drosophila
    K Basler
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, N Y 10032
    Bioessays 13:621-31. 1991
    ..Genetic dissection of this pathway should therefore identify components of a signalling cascade activated by a tyrosine kinase...
  72. ncbi Role of helix-loop-helix proteins in Drosophila neurogenesis
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Cold Spring Harb Symp Quant Biol 55:239-45. 1990
  73. pmc Autoregulatory functioning of a Drosophila gene product that establish es and maintains the sexually determined state
    T W Cline
    Genetics 107:231-77. 1984
    ..Some of these sex-transforming Sxl mutants do not require the maternally produced da(+) activity that is normally essential for the functioning of zygotic Sxl alleles...
  74. ncbi Diploidy of Drosophila imaginal cells is maintained by a transcriptional repressor encoded by escargot
    N Fuse
    Graduate University for Advanced Studies, National Institute of Genetics, Shizuoka ken, Japan
    Genes Dev 8:2270-81. 1994
    ..Ectopic expression of esg in the salivary glands inhibits endoreplication of DNA. These results suggest that esg is involved in transcriptional inhibition of genes required for endoreplication...
  75. ncbi Polytene chromosomes of monogenic and amphogenic Chrysomya species (Calliphoridae, Diptera): analysis of banding patterns and in situ hybridization with Drosophila sex determining gene sequences
    S Puchalla
    Zoologisches Institut, Universitat Kiel, Germany
    Chromosoma 103:16-30. 1994
    ..and amphogenic Chrysomya species contains sequences homologous to the maternal sex determining gene daughterless (da). Homology to the zygotic gene Sex-lethal (Sxl) of Drosophila is detected in band 39A1 on chromosome 5 of C...
  76. ncbi A dual role for the protein kinase shaggy in the repression of achaete-scute
    P Simpson
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Dev Suppl . 1993
    ..shaggy is required downstream of Notch for transduction of the inhibitory signal. This second role of shaggy may be due to modulation of enzymatic activity during signalling...
  77. ncbi Sex determination in Drosophila melanogaster: X-linked genes involved in the initial step of sex-lethal activation
    L Sanchez
    Centro de Investigaciones Biologicas, Velazquez, Madrid, Spain
    Dev Genet 15:251-64. 1994
    ..We review these data and present new data on two more regions of the X chromosome that define other genes needed for Sxl activation. In addition, we report on the interaction between some of the genes regulating Sxl activation...
  78. ncbi achaete-scute feminizing activities and Drosophila sex determination
    S M Parkhurst
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Development 117:737-49. 1993
    ..Detailed examination of Sxl expression in rescued embryos suggests that female cells may be viable in the absence of detectable Sxl protein expression...
  79. ncbi A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster
    N J Clegg
    Department of Zoology, University of British Columbia, Canada
    Genome 36:676-85. 1993
    ..The phenotypes of our mutants are consistent with a role for Cdc2 in cell proliferation; however, we did not observe any perturbation of the endoreduplication cycle associated with the acquisition of polyteny...
  80. ncbi Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
    P Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, Strasbourg, France
    Development 122:161-71. 1996
    ..Thus there is a regulatory loop between Notch and Delta that is under the transcriptional control of the E(spl)-C and AS-C genes...
  81. ncbi Proneural and neurogenic genes control specification and Morphogenesis of stomatogastric nerve cell precursors in Drosophila
    V Hartenstein
    Department of Biology, University of California, Los Angeles 90095 1606, USA
    Dev Biol 173:213-27. 1996
    ....
  82. ncbi Drosophila differentiation genes instrumental in tumor suppression
    E Gateff
    Institut fur Genetik, Johannes Gutenberg Universitat, Mainz, Germany
    Int J Dev Biol 40:149-56. 1996
    ....
  83. ncbi Regulatory interactions during early neurogenesis in Drosophila
    B Hassan
    Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus 43210, USA
    Dev Genet 18:18-27. 1996
    ..While lineage identity genes allow the various lineages to acquire specific identities, neuronal precursor genes presumably regulate functional and developmental characteristics common to all neuronal precursor cells...
  84. ncbi Myc and Max homologs in Drosophila
    P Gallant
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle WA 98104, USA
    Science 274:1523-7. 1996
    ..These findings indicate a potential role for Myc in germ cell development and set the stage for genetic analysis of Myc and Max...
  85. pmc Groucho-dependent and -independent repression activities of Runt domain proteins
    B D Aronson
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, 11794 5215, USA
    Mol Cell Biol 17:5581-7. 1997
    ..Unlike other transcriptional regulatory proteins that interact with Groucho, Runt domain proteins are known to activate transcription. This suggests that the Runt domain protein-Groucho interaction may be regulated...
  86. ncbi Nucleotide compositional constraints on genomes generate alanine-, glycine-, and proline-rich structures in transcription factors
    Y Nakachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Mol Biol Evol 14:1042-9. 1997
    ..Furthermore, reptile class III POU sequences revealed no evolutionary directionality increasing the GC contents from cold- to warm-blooded vertebrates...
  87. ncbi Control of cell lineage-specific development and transcription by bHLH-PAS proteins
    S T Crews
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7260 USA
    Genes Dev 12:607-20. 1998
  88. pmc Krüppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of Drosophila
    M Hoch
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, D 37077 Gottingen, Germany
    EMBO J 17:5766-75. 1998
    ....
  89. ncbi Evolutionary conservation of MyoD function and differential utilization of E proteins
    J M Zhang
    Laboratory of Biochemistry, NCI, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 208:465-72. 1999
    ..elegans CeMyoD loss-of-function mutation. These results demonstrate a remarkable degree of functional conservation of these myogenic factors despite differences in E-protein interactions...
  90. ncbi The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system
    M L Huang
    Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
    Neuron 25:57-67. 2000
    ..Amos interacts with the ubiquitously expressed Daughter-less protein in vivo and in vitro. Our final misexpression experiments suggest that a domain located outside the DNA-binding domain of Amos determines the MD neuronal specificity...
  91. ncbi amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge
    S E Goulding
    Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
    Neuron 25:69-78. 2000
    ..We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS...
  92. ncbi Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse
    E Segev
    Department of Cell and Animal Biology, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    Mech Dev 106:197-202. 2001
    ..In contrast to the brain, expression in the spinal cord was limited to the embryonic stages...
  93. ncbi The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulation
    J E Smith
    Department of Biology, Gilmer Hall, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
    Development 128:4705-14. 2001
    As the only class I helix-loop-helix transcription factor in Drosophila, Daughterless (Da) has generally been regarded as a ubiquitously expressed binding partner for other developmentally regulated bHLH transcription factors...
  94. pmc Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation
    Francoise Chanut
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    Genetics 160:623-35. 2002
    ..We show that Roi can rescue the retinal developmental defect of ato1 mutants and speculate that amos substitutes for some of ato's function in the eye or activates a residual function of the ato1 allele...
  95. ncbi senseless is necessary for the survival of embryonic salivary glands in Drosophila
    Vidya Chandrasekaran
    Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Development 130:4719-28. 2003
    ..The expression of sens is maintained in the salivary glands by fkh and by daughterless (da), a bHLH family member...
  96. pmc Genetic complexity underlying hybrid male sterility in Drosophila
    Kyoichi Sawamura
    Drosophila Genetic Resource Center, Kyoto Institute of Technology, Kyoto 616 8354, Japan
    Genetics 166:789-96. 2004
    ..Such an epistatic view, even in the less-related species, suggests that the genetic complexity is special to hybrid male sterility...
  97. ncbi Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator
    Melih Acar
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 133:1979-89. 2006
    ....
  98. pmc Two closely linked mutations in Drosophila melanogaster that are lethal to opposite sexes and interact with daughterless
    T W Cline
    Genetics 90:683-98. 1978
    ..repect, particularly with regard to their interaction with maternal effect of the autosomal mutation, daughterless (da). Females that are homozygous for da produce defective eggs that cannot support female (XX) development...
  99. ncbi How do germ cells choose their sex? Drosophila as a paradigm
    M Steinmann-Zwicky
    Zoological Institute, University of Zurich, Switzerland
    Bioessays 14:513-8. 1992
    ..Some of the genes that are involved in germ line sex determination have been identified. In other species, including vertebrates, inductive signals are commonly used to determine the sex of germ cells...
  100. pmc Evidence of a dual function in fl(2)d, a gene needed for Sex-lethal expression in Drosophila melanogaster
    B Granadino
    Centro de Investigaciones Biologicas, Madrid, Spain
    Genetics 130:597-612. 1992
    ..There is no female synergistic lethality between mutations at fl(2)d and neither at sc or da. However, the female synergistic lethality between mutations at Sxl and either sc or da is increased by fl(2)d ..
  101. ncbi The helix-loop-helix domain: a common motif for bristles, muscles and sex
    J Garrell
    Centro de Biologia Molecular, CSIC UAM, Madrid, Spain
    Bioessays 13:493-8. 1991
    ..These structural properties provide a molecular mechanism to explain the synergistic and antagonistic functional relations among the HLH encoding genes that control several developmental pathways...

Research Grants5

  1. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
    ..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
  2. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ....
  3. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
    ..We have identified the daughterless (da) gene as potential direct target of Wg-dependent bristle inhibition in the eye...
  4. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
  5. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
    ..abstract_text> ..

Patents1

  1. PLASMIDES FOR THE EXPRESSION OF FILAMENTOUS HAEMAGGLUTININ (FHA) AND HOSTS THEREFOR
    Patent Number: WO9218624-A1; Date:1992-10-29