da

Summary

Gene Symbol: da
Description: daughterless
Alias: 5102, CG5102, Dmel\CG5102, bHLHb22, l(2)31Ea, CG5102-PA, CG5102-PB, CG5102-PC, da-PA, da-PB, da-PC, daughter-less
Species: fruit fly

Top Publications

  1. ncbi The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila
    M Caudy
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Genes Dev 2:843-52. 1988
  2. ncbi Dosage compensation in Drosophila: the X chromosome binding of MSL-1 and MSL-2 in female embryos is prevented by the early expression of the Sxl gene
    K A McDowell
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Mech Dev 57:113-9. 1996
  3. pmc Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis
    Ming Ching Wong
    Weill Graduate School of Medical Sciences, Cornell University, New York, NY, USA
    Dev Biol 317:417-29. 2008
  4. ncbi Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
    C Murre
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 58:537-44. 1989
  5. ncbi The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins
    Hiroshi Tsuda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 122:633-44. 2005
  6. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
  7. pmc Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila
    C V Cabrera
    Marie Curie Research Institute, Oxted, Surrey, UK
    EMBO J 10:2965-73. 1991
  8. pmc fs (1) Yb is required for ovary follicle cell differentiation in Drosophila melanogaster and has genetic interactions with the Notch group of neurogenic genes
    E Johnson
    Genetics Program, University of Iowa, Iowa City 52242, USA
    Genetics 140:207-17. 1995
  9. ncbi Molecular characterization of daughterless, a Drosophila sex determination gene with multiple roles in development
    C Cronmiller
    Department of Biology, Princeton University, New Jersey 08544 1003
    Genes Dev 2:1666-76. 1988
  10. ncbi daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex
    M Caudy
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143
    Cell 55:1061-7. 1988

Research Grants

  1. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
  2. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
  3. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
  4. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
  5. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010

Scientific Experts

  • Kyoichi Sawamura
  • John W Cave
  • Stephen Crews
  • Eric C Lai
  • Madina J Sukhanova
  • F Huang
  • S Campuzano
  • C S Wesley
  • B Giebel
  • Kenneth Cadigan
  • Trudy F Mackay
  • C Q Doe
  • J Modolell
  • Matthieu Louis
  • N E Baker
  • Francoise Chanut
  • Hamed Jafar-Nejad
  • Ginnene M Distefano
  • Mona Abed
  • Abhishek Bhattacharya
  • Nikolaos Giagtzoglou
  • Afshan Ismat
  • Xin Li
  • Stewart MacArthur
  • Ming Ching Wong
  • Tetsuo Yasugi
  • Alejandra N González
  • Pao Ju Chang
  • Melih Acar
  • Hugo J Bellen
  • Hiroshi Tsuda
  • Christos Delidakis
  • Xiao Jiang Quan
  • C Cronmiller
  • Vidya Chandrasekaran
  • Benjamin J Frankfort
  • Daniel R Marenda
  • Andrew J Gangemi
  • E Segev
  • J E Smith
  • Preeti J Khandelwal
  • Aleister J Saunders
  • Bella Koltun
  • M Caudy
  • Amir Orian
  • Susan M Parkhurst
  • Taryn M Phippen
  • Jeffrey J Delrow
  • Kevin C Barry
  • Dorit Kenyagin
  • Ingolf Reim
  • Katharina Kirchner
  • Q Wei
  • S M Parkhurst
  • S E Goulding
  • Manfred Frasch
  • Christoph Schaub
  • M L Huang
  • Dorothea Schultheis
  • Lisa Simirenko
  • Soile V E Keränen
  • B M Paterson
  • Mark D Biggin
  • Lucy Zeng
  • Brandi P Grondona
  • James B Brown
  • Stephen Fischboeck
  • Mark Stapleton
  • David W Knowles
  • Aaron Hechmer
  • Jingyi Li
  • Peter Bickel
  • Hou Cheng Chu
  • Xiao Yong Li
  • Richard W Carthew
  • Michael B Eisen
  • Catherine A Reinke
  • Justin J Cassidy
  • James W Erickson
  • K King-Jones
  • Tetsuya Tabata
  • Yi Chen Li
  • An Chi Tien
  • Irinka Castanon
  • B Morgenstern
  • Mary K Baylies
  • Satoshi Murakami
  • Hong Lu
  • Daiki Umetsu
  • J M Zhang

Detail Information

Publications85

  1. ncbi The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila
    M Caudy
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Genes Dev 2:843-52. 1988
    The daughterless (da) gene is known to have separate maternal and zygotic functions: Maternally supplied daughterless activity is required for proper sex determination and dosage compensation in female embryos, whereas loss of zygotically ..
  2. ncbi Dosage compensation in Drosophila: the X chromosome binding of MSL-1 and MSL-2 in female embryos is prevented by the early expression of the Sxl gene
    K A McDowell
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Mech Dev 57:113-9. 1996
    ....
  3. pmc Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis
    Ming Ching Wong
    Weill Graduate School of Medical Sciences, Cornell University, New York, NY, USA
    Dev Biol 317:417-29. 2008
    ..its dimerization partner: Twi homodimers activate genes necessary for somatic myogenesis, whereas Twi/Daughterless (Da) heterodimers lead to the repression of these genes...
  4. ncbi Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
    C Murre
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 58:537-44. 1989
    ..A role of E12 and E47 in mammalian development, analogous to that of daughterless in Drosophila, is likely...
  5. ncbi The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins
    Hiroshi Tsuda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 122:633-44. 2005
    ..Interestingly, loss of Gfi-1 mimics SCA1 phenotypes in Purkinje cells. These results indicate that the Atx-1/Gfi-1 interaction contributes to the selective Purkinje cell degeneration in SCA1...
  6. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  7. pmc Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of Drosophila
    C V Cabrera
    Marie Curie Research Institute, Oxted, Surrey, UK
    EMBO J 10:2965-73. 1991
    The achaete-scute complex (AS-C) and the daughterless (da) genes encode helix-loop-helix proteins which have been shown to interact in vivo and to be required for neurogenesis...
  8. pmc fs (1) Yb is required for ovary follicle cell differentiation in Drosophila melanogaster and has genetic interactions with the Notch group of neurogenic genes
    E Johnson
    Genetics Program, University of Iowa, Iowa City 52242, USA
    Genetics 140:207-17. 1995
    ..We propose that fs (1) Yb acts as an ovary-specific factor that determines follicle cell fate...
  9. ncbi Molecular characterization of daughterless, a Drosophila sex determination gene with multiple roles in development
    C Cronmiller
    Department of Biology, Princeton University, New Jersey 08544 1003
    Genes Dev 2:1666-76. 1988
    The daughterless (da) gene in Drosophila acts both maternally and zygotically to provide essential functions during development...
  10. ncbi daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex
    M Caudy
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143
    Cell 55:1061-7. 1988
    daughterless (da) has multiple functions in Drosophila embryonic development: maternal da activity is necessary for proper sex determination, and zygotic da activity is necessary for formation of the peripheral nervous system...
  11. ncbi The relationship of relative gene dose to the complex phenotype of the daughterless locus in Drosophila
    C Cronmiller
    Department of Biology, Princeton University, NJ 08544
    Dev Genet 7:205-21. 1986
    The daughterless (da) gene provides an essential maternally supplied component for Drosophila sex determination and dosage compensation...
  12. ncbi Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of Daughterless
    Kenneth M Cadigan
    Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, Stanford, California 94305, USA
    Development 129:3393-402. 2002
    ..These results are summarized in a model where daughterless is a major, but probably not the only, target of wingless action in the eye...
  13. ncbi daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
    Development 120:935-45. 1994
    ..genes of the achaete-scute complex AS-C (achaete (ac), scute (sc) and lethal of scute (l'sc)) and daughterless (da). The da protein dimerizes with AS-C products in vitro to form DNA-binding proteins...
  14. pmc Proneural basic helix-loop-helix proteins and epidermal growth factor receptor signaling coordinately regulate cell type specification and cdk inhibitor expression during development
    Madina J Sukhanova
    Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
    Mol Cell Biol 27:2987-96. 2007
    ..transcription factor Pointed (Pnt) and the proneural basic helix-loop-helix proteins Atonal (Ato) and Daughterless (Da)...
  15. ncbi The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during development
    C Cronmiller
    Department of Biology, University of Virginia, Charlottesville 22901
    Mech Dev 42:159-69. 1993
    The daughterless (da) gene in Drosophila functions in the regulation of at least three significant developmental pathways: sex determination, neurogenesis and oogenesis...
  16. ncbi Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster
    D Bopp
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    Genes Dev 5:403-15. 1991
    ..The onset of Sxl expression in the germ line occurs later than that in the soma...
  17. pmc A shared enhancer controls a temporal switch between promoters during Drosophila primary sex determination
    Alejandra N González
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 105:18436-41. 2008
    ....
  18. ncbi The primary sex determination signal of Drosophila acts at the level of transcription
    L N Keyes
    Department of Biology, Princeton University, New Jersey 08544
    Cell 68:933-43. 1992
    ..The proteins produced from these early mRNAs then initiate the autoregulatory loop by directing the female-specific processing of transcripts from the late Sxl promoter...
  19. ncbi Evolution of neural precursor selection: functional divergence of proneural proteins
    Xiao Jiang Quan
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, Belgium
    Development 131:1679-89. 2004
    ..These data suggest an evolutionary divergence in the mechanisms of NPC selection between protostomes and deuterostomes...
  20. ncbi daughterless is required for Drosophila photoreceptor cell determination, eye morphogenesis, and cell cycle progression
    N L Brown
    Howard Hughes Medical Institute and Bock Laboratories, Madison, Wisconsin 53706, USA
    Dev Biol 179:65-78. 1996
    ..basic helix-loop-helix (bHLH) transcription factors that dimerize in vitro with another bHLH protein, daughterless (da)...
  21. ncbi The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes
    M Van Doren
    Department of Biology, University of California San Diego, La Jolla 92093 0322
    Development 113:245-55. 1991
    ..Proteins encoded by the daughterless (da) gene and three genes of the achaete-scute complex (AS-C) act positively in the determination of the sensory organ ..
  22. ncbi Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signaling
    A Singson
    Department of Biology, University of California San Diego, La Jolla 92093 0322
    Genes Dev 8:2058-71. 1994
    ..Thus, one of the earliest steps in adult peripheral neurogenesis is the direct activation by proneural proteins of genes involved in restricting the expression of the SOP cell fate...
  23. pmc HLH54F is required for the specification and migration of longitudinal gut muscle founders from the caudal mesoderm of Drosophila
    Afshan Ismat
    Mount Sinai School of Medicine, Department of Molecular, Cell and Developmental Biology currently Developmental and Regenerative Biology, Box 1020, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 137:3107-17. 2010
    ..We conclude that HLH54F is the earliest specific regulator of CVM development and that it plays a pivotal role in all major aspects of development and differentiation of this largely twist-independent population of mesodermal cells...
  24. doi Drosophila lilliputian is required for proneural gene expression in retinal development
    Ginnene M Distefano
    Department of Biology, Drexel University, Philadelphia, Pennsylvania 19104, USA
    Dev Dyn 241:553-62. 2012
    ..expression of the basic helix-loop-helix (bHLH) proneural transcription factors Atonal (Ato) and Daughterless (Da)...
  25. pmc Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression
    Mona Abed
    Cancer and Vascular Biology Research Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    EMBO J 30:1289-301. 2011
    ..As Gro/TLE proteins are conserved universal corepressors, this may be a general paradigm used to regulate the Gro/TLE corepressors in other developmental processes...
  26. pmc A network of broadly expressed HLH genes regulates tissue-specific cell fates
    Abhishek Bhattacharya
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 147:881-92. 2011
    ..In Drosophila, a cross-interacting regulatory network links expression of the E protein Daughterless (Da), which heterodimerizes with bHLH proteins to activate them, with expression of the Id protein Extramacrochaetae (..
  27. ncbi Evolutionary conservation of MyoD function and differential utilization of E proteins
    J M Zhang
    Laboratory of Biochemistry, NCI, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 208:465-72. 1999
    ..elegans CeMyoD loss-of-function mutation. These results demonstrate a remarkable degree of functional conservation of these myogenic factors despite differences in E-protein interactions...
  28. pmc Krüppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of Drosophila
    M Hoch
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, D 37077 Gottingen, Germany
    EMBO J 17:5766-75. 1998
    ....
  29. ncbi The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulation
    J E Smith
    Department of Biology, Gilmer Hall, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
    Development 128:4705-14. 2001
    As the only class I helix-loop-helix transcription factor in Drosophila, Daughterless (Da) has generally been regarded as a ubiquitously expressed binding partner for other developmentally regulated bHLH transcription factors...
  30. ncbi Nucleotide compositional constraints on genomes generate alanine-, glycine-, and proline-rich structures in transcription factors
    Y Nakachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Mol Biol Evol 14:1042-9. 1997
    ..Furthermore, reptile class III POU sequences revealed no evolutionary directionality increasing the GC contents from cold- to warm-blooded vertebrates...
  31. ncbi The function of hairy-related bHLH repressor proteins in cell fate decisions
    A Fisher
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York, USA
    Bioessays 20:298-306. 1998
    ..This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis...
  32. ncbi Myc and Max homologs in Drosophila
    P Gallant
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle WA 98104, USA
    Science 274:1523-7. 1996
    ..These findings indicate a potential role for Myc in germ cell development and set the stage for genetic analysis of Myc and Max...
  33. pmc Groucho-dependent and -independent repression activities of Runt domain proteins
    B D Aronson
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, 11794 5215, USA
    Mol Cell Biol 17:5581-7. 1997
    ..Unlike other transcriptional regulatory proteins that interact with Groucho, Runt domain proteins are known to activate transcription. This suggests that the Runt domain protein-Groucho interaction may be regulated...
  34. ncbi Control of cell lineage-specific development and transcription by bHLH-PAS proteins
    S T Crews
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7260 USA
    Genes Dev 12:607-20. 1998
  35. ncbi The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system
    M L Huang
    Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
    Neuron 25:57-67. 2000
    ..Amos interacts with the ubiquitously expressed Daughter-less protein in vivo and in vitro. Our final misexpression experiments suggest that a domain located outside the DNA-binding domain of Amos determines the MD neuronal specificity...
  36. ncbi amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge
    S E Goulding
    Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
    Neuron 25:69-78. 2000
    ..We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS...
  37. doi Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT
    Tetsuo Yasugi
    Laboratory of Pattern Formation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:1471-80. 2008
    ....
  38. pmc Genetic complexity underlying hybrid male sterility in Drosophila
    Kyoichi Sawamura
    Drosophila Genetic Resource Center, Kyoto Institute of Technology, Kyoto 616 8354, Japan
    Genetics 166:789-96. 2004
    ..Such an epistatic view, even in the less-related species, suggests that the genetic complexity is special to hybrid male sterility...
  39. ncbi senseless is necessary for the survival of embryonic salivary glands in Drosophila
    Vidya Chandrasekaran
    Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
    Development 130:4719-28. 2003
    ..The expression of sens is maintained in the salivary glands by fkh and by daughterless (da), a bHLH family member...
  40. ncbi Two modes of recruitment of E(spl) repressors onto target genes
    Nikolaos Giagtzoglou
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Greece
    Development 130:259-70. 2003
    ..Irrespective of whether E(spl) are recruited via direct DNA binding or interaction with proneural proteins, the co-repressor Groucho is always needed for target gene repression...
  41. doi Negative-feedback regulation of proneural proteins controls the timing of neural precursor division
    Pao Ju Chang
    Department of Life Science, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan 333, Taiwan
    Development 135:3021-30. 2008
    ..As phyl is a direct transcriptional target of Ac and Sc, our data suggest that, in addition to mediating cell cycle arrest, proneural protein initiates a negative-feedback regulation to time the mitotic entry of neural precursors...
  42. pmc A microRNA imparts robustness against environmental fluctuation during development
    Xin Li
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
    Cell 137:273-82. 2009
    ..We suggest that some conserved microRNAs like miR-7 may enter into novel genetic relationships to buffer developmental programs against variation and impart robustness to diverse regulatory networks...
  43. pmc Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation
    Francoise Chanut
    Department of Anatomy, University of California, San Francisco, California 94143, USA
    Genetics 160:623-35. 2002
    ..We show that Roi can rescue the retinal developmental defect of ato1 mutants and speculate that amos substitutes for some of ato's function in the eye or activates a residual function of the ato1 allele...
  44. ncbi Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator
    Melih Acar
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 133:1979-89. 2006
    ....
  45. ncbi Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse
    E Segev
    Department of Cell and Animal Biology, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    Mech Dev 106:197-202. 2001
    ..In contrast to the brain, expression in the spinal cord was limited to the embryonic stages...
  46. ncbi Regulatory interactions during early neurogenesis in Drosophila
    B Hassan
    Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus 43210, USA
    Dev Genet 18:18-27. 1996
    ..While lineage identity genes allow the various lineages to acquire specific identities, neuronal precursor genes presumably regulate functional and developmental characteristics common to all neuronal precursor cells...
  47. ncbi Drosophila differentiation genes instrumental in tumor suppression
    E Gateff
    Institut fur Genetik, Johannes Gutenberg Universitat, Mainz, Germany
    Int J Dev Biol 40:149-56. 1996
    ....
  48. ncbi Proneural and neurogenic genes control specification and Morphogenesis of stomatogastric nerve cell precursors in Drosophila
    V Hartenstein
    Department of Biology, University of California, Los Angeles 90095 1606, USA
    Dev Biol 173:213-27. 1996
    ....
  49. ncbi Polytene chromosomes of monogenic and amphogenic Chrysomya species (Calliphoridae, Diptera): analysis of banding patterns and in situ hybridization with Drosophila sex determining gene sequences
    S Puchalla
    Zoologisches Institut, Universitat Kiel, Germany
    Chromosoma 103:16-30. 1994
    ..and amphogenic Chrysomya species contains sequences homologous to the maternal sex determining gene daughterless (da). Homology to the zygotic gene Sex-lethal (Sxl) of Drosophila is detected in band 39A1 on chromosome 5 of C...
  50. ncbi Diploidy of Drosophila imaginal cells is maintained by a transcriptional repressor encoded by escargot
    N Fuse
    Graduate University for Advanced Studies, National Institute of Genetics, Shizuoka ken, Japan
    Genes Dev 8:2270-81. 1994
    ..Ectopic expression of esg in the salivary glands inhibits endoreplication of DNA. These results suggest that esg is involved in transcriptional inhibition of genes required for endoreplication...
  51. pmc Evidence for a set of closely linked autosomal genes that interact with sex-chromosome heterochromatin in Drosophila melanogaster
    L Sandler
    Genetics 86:567-82. 1977
    ..The nature of this interaction and possible reasons for the existence of the cluster of autosomal genes are discussed...
  52. pmc Autoregulatory functioning of a Drosophila gene product that establish es and maintains the sexually determined state
    T W Cline
    Genetics 107:231-77. 1984
    ..Some of these sex-transforming Sxl mutants do not require the maternally produced da(+) activity that is normally essential for the functioning of zygotic Sxl alleles...
  53. ncbi A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
    C Murre
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 56:777-83. 1989
    ..Remarkable is the stringent conservation of hydrophobic residues present in both helices. We demonstrate that this new motif plays a crucial role in both dimerization and DNA binding...
  54. ncbi Role of helix-loop-helix proteins in Drosophila neurogenesis
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Cold Spring Harb Symp Quant Biol 55:239-45. 1990
  55. ncbi Specification of cell fate in the developing eye of Drosophila
    K Basler
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, N Y 10032
    Bioessays 13:621-31. 1991
    ..Genetic dissection of this pathway should therefore identify components of a signalling cascade activated by a tyrosine kinase...
  56. ncbi The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal
    J B Duffy
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 5:2176-87. 1991
    ..runt is distinguished from previously identified regulators of Sxl by its nonuniform role and by the absence of an identifiable helix-loop-helix (HLH) motif, indicating that the activation of Sxl is not controlled solely by HLH proteins...
  57. ncbi Calmodulin transcription is limited to the nervous system during Drosophila embryogenesis
    G E Kovalick
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005
    Dev Biol 150:33-46. 1992
    ..The calmodulin transcription pattern is altered in embryos mutant for each of these loci, suggesting that regulation by these genes, either directly or indirectly, is taking place...
  58. ncbi The segmentation gene runt is needed to activate Sex-lethal, a gene that controls sex determination and dosage compensation in Drosophila
    M Torres
    Centro de Investigaciones Biologicas, Madrid, Spain
    Genet Res 59:189-98. 1992
    ..We conclude that runt is needed for the initial step of Sex-lethal activation, but does not have a major role as an X-counting element...
  59. ncbi Sex determination and differentiation in invertebrates: Drosophila and Caenorhabditis elegans
    M McKeown
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Curr Opin Cell Biol 4:948-54. 1992
    ..We are now gaining an understanding of the molecular mechanisms governing the largely post-transcriptional regulation of the intermediate steps in these cascades...
  60. ncbi Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae
    M Van Doren
    Department of Biology and Center for Molecular Genetics, University of California San Diego, La Jolla 92093 0322
    Genes Dev 6:2592-605. 1992
    ..Our results indicate that emc plays an essential early role in defining territories of bristle-forming potential...
  61. ncbi Sex determination in Drosophila melanogaster: X-linked genes involved in the initial step of sex-lethal activation
    L Sanchez
    Centro de Investigaciones Biologicas, Velazquez, Madrid, Spain
    Dev Genet 15:251-64. 1994
    ..We review these data and present new data on two more regions of the X chromosome that define other genes needed for Sxl activation. In addition, we report on the interaction between some of the genes regulating Sxl activation...
  62. ncbi The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes
    U Hinz
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
    Cell 76:77-87. 1994
    ..Finally, the bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition...
  63. ncbi achaete-scute feminizing activities and Drosophila sex determination
    S M Parkhurst
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Development 117:737-49. 1993
    ..Detailed examination of Sxl expression in rescued embryos suggests that female cells may be viable in the absence of detectable Sxl protein expression...
  64. ncbi Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
    P Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, Strasbourg, France
    Development 122:161-71. 1996
    ..Thus there is a regulatory loop between Notch and Delta that is under the transcriptional control of the E(spl)-C and AS-C genes...
  65. ncbi asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation
    M Brand
    Howard Huges Medical Institute, University of California, San Francisco, CA 94143 0724, USA
    Development 119:1-17. 1993
    ..Our studies therefore serve as a cautionary note for the inference of normal gene function based on the gain-of-function phenotype after ectopic expression...
  66. ncbi A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster
    N J Clegg
    Department of Zoology, University of British Columbia, Canada
    Genome 36:676-85. 1993
    ..The phenotypes of our mutants are consistent with a role for Cdc2 in cell proliferation; however, we did not observe any perturbation of the endoreduplication cycle associated with the acquisition of polyteny...
  67. ncbi (HX)n repeats: a pH-controlled protein-protein interaction motif of eukaryotic transcription factors?
    R Janknecht
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Germany
    FEBS Lett 295:1-2. 1991
    ..g. HPHAHPHP in paired protein. Detailed molecular modelling and database searches lead to the suggestion that (HX)n repeats can mediate interaction between transcription factors in a pH-controlled fashion...
  68. ncbi Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila
    S González-Crespo
    Department of Biology, University of California at San Diego, La Jolla 92093 0322
    Genes Dev 7:1703-13. 1993
    ..Evidence is also presented that dl-HLH interactions involve the direct physical association of these proteins in solution mediated by the rel and HLH domains. We discuss the striking parallels in mesoderm formation and sex determination...
  69. pmc Evidence of a dual function in fl(2)d, a gene needed for Sex-lethal expression in Drosophila melanogaster
    B Granadino
    Centro de Investigaciones Biologicas, Madrid, Spain
    Genetics 130:597-612. 1992
    ..There is no female synergistic lethality between mutations at fl(2)d and neither at sc or da. However, the female synergistic lethality between mutations at Sxl and either sc or da is increased by fl(2)d ..
  70. ncbi How do germ cells choose their sex? Drosophila as a paradigm
    M Steinmann-Zwicky
    Zoological Institute, University of Zurich, Switzerland
    Bioessays 14:513-8. 1992
    ..Some of the genes that are involved in germ line sex determination have been identified. In other species, including vertebrates, inductive signals are commonly used to determine the sex of germ cells...
  71. ncbi Neurogenesis in the insect central nervous system
    C Q Doe
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Curr Opin Neurobiol 6:18-24. 1996
    ..And finally, new cell-lineage methods are being used to determine the entire lineage of identified neuroblasts, including axon projections and synaptic contacts...
  72. ncbi The helix-loop-helix domain: a common motif for bristles, muscles and sex
    J Garrell
    Centro de Biologia Molecular, CSIC UAM, Madrid, Spain
    Bioessays 13:493-8. 1991
    ..These structural properties provide a molecular mechanism to explain the synergistic and antagonistic functional relations among the HLH encoding genes that control several developmental pathways...
  73. ncbi Bristle patterning in Drosophila
    L I Held
    Department of Biological Sciences, Texas Tech University, Lubbock 79409
    Bioessays 13:633-40. 1991
    ..Some of the genes that control these events participate in more than one stage, and others play key roles in seemingly unrelated developmental pathways, including embryonic neurogenesis, body segmentation, and sex determination...
  74. ncbi Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: epidermogenesis or neurogenesis
    J A Campos-Ortega
    Institut für Entwicklungsphysiologie, Universitat zu Koln, Federal Republic of Germany
    Eur J Biochem 190:1-10. 1990
    ....
  75. ncbi RNA interference demonstrates a role for nautilus in the myogenic conversion of Schneider cells by daughterless
    Q Wei
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Biol 228:239-55. 2000
    ..These results support the conclusion that nautilus is a myogenic factor in Drosophila tissue culture cells with a functional role similar to that of vertebrate MyoD. This is discussed with regard to the in vivo functions of nautilus...
  76. ncbi Evolution of bHLH transcription factors: modular evolution by domain shuffling?
    B Morgenstern
    GSF, National Research Center for Environment and Health, Institute of Biomathematics and Biometry, Neuherberg, Germany
    Mol Biol Evol 16:1654-63. 1999
    ..Drawing on several lines of evidence, we suggest that modular evolution by domain shuffling may have played an important role in the evolution of this large group of transcriptional regulators...
  77. ncbi The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4
    K King-Jones
    Institut für Genetik der Freien Universität Berlin, Arnimallee 7, Berlin, D 14195, Germany
    J Mol Biol 291:71-82. 1999
    ..As a second component of SEBP3 we identified the Daughterless (Da) protein, which is also ubiquitously expressed and binds to SEBP3 sites independent of dAP-4...
  78. ncbi Cloning and analysis of a new developmentally regulated member of the basic helix-loop-helix family
    J A Helms
    Neuroscience Program, University of Connecticut Health Center, Farmington 06032
    Mech Dev 48:93-108. 1994
    ..Strikingly, GbHLH1.4 expression in chick embryos exhibits significant overlap with that reported for the murine negative HLH regulator, Id...
  79. ncbi Neurogenic expression of snail is controlled by separable CNS and PNS promoter elements
    Y T Ip
    Department of Biology, University of California, San Diego, La Jolla 92093 0322
    Development 120:199-207. 1994
    ..e. da and AS-C), are expressed in both the CNS and PNS...
  80. ncbi Sex determination and dosage compensation: lessons from flies and worms
    S M Parkhurst
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Science 264:924-32. 1994
    ..Instead, the study of sex determination and dosage compensation is providing more general lessons about different types of signaling pathways used to control alternative developmental states of cells and organisms...
  81. ncbi Neural enhancer-like elements as specific cell markers in Drosophila
    A Ghysen
    Laboratoire de Genetique, Universite Libre de Bruxelles, Rhode St Genese, Belgium
    Development 105:35-52. 1989
    ..In the other three strains, the fusion product is expressed in unique subsets of cells of the peripheral nervous system, as well as in some other tissues...
  82. pmc Two closely linked mutations in Drosophila melanogaster that are lethal to opposite sexes and interact with daughterless
    T W Cline
    Genetics 90:683-98. 1978
    ..repect, particularly with regard to their interaction with maternal effect of the autosomal mutation, daughterless (da). Females that are homozygous for da produce defective eggs that cannot support female (XX) development...
  83. ncbi Genetic analysis of the Drosophila cdc2 homolog
    B Stern
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, FRG
    Development 117:219-32. 1993
    ..These results indicate that the Dm cdc2- and Dm cdc2c-kinases control different processes...
  84. ncbi R8 development in the Drosophila eye: a paradigm for neural selection and differentiation
    Benjamin J Frankfort
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 129:1295-306. 2002
    ....

Research Grants5

  1. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
    ..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
  2. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ....
  3. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
    ..We have identified the daughterless (da) gene as potential direct target of Wg-dependent bristle inhibition in the eye...
  4. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
  5. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
    ..abstract_text> ..