Genomes and Genes
Gene Symbol: da
Alias: 5102, CG5102, Dmel\CG5102, SC_DA, bHLHb22, l(2)31Ea, l(2)k08611, CG5102 gene product from transcript CG5102-RB, CG5102-PA, CG5102-PB, CG5102-PC, da-PA, da-PB, da-PC, daughter-less, lethal (2) k08611
Species: fruit fly
Publications113 found, 100 shown here
- Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesisMing Ching Wong
Weill Graduate School of Medical Sciences, Cornell University, New York, NY, USA
Dev Biol 317:417-29. 2008..its dimerization partner: Twi homodimers activate genes necessary for somatic myogenesis, whereas Twi/Daughterless (Da) heterodimers lead to the repression of these genes...
- The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in DrosophilaM Caudy
Howard Hughes Medical Institute, University of California, San Francisco 94143
Genes Dev 2:843-52. 1988The daughterless (da) gene is known to have separate maternal and zygotic functions: Maternally supplied daughterless activity is required for proper sex determination and dosage compensation in female embryos, whereas loss of zygotically ..
- Dosage compensation in Drosophila: the X chromosome binding of MSL-1 and MSL-2 in female embryos is prevented by the early expression of the Sxl geneK A McDowell
Department of Biology, Emory University, Atlanta, GA 30322, USA
Mech Dev 57:113-9. 1996....
- The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteinsHiroshi Tsuda
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 122:633-44. 2005..Interestingly, loss of Gfi-1 mimics SCA1 phenotypes in Purkinje cells. These results indicate that the Atx-1/Gfi-1 interaction contributes to the selective Purkinje cell degeneration in SCA1...
- fs (1) Yb is required for ovary follicle cell differentiation in Drosophila melanogaster and has genetic interactions with the Notch group of neurogenic genesE Johnson
Genetics Program, University of Iowa, Iowa City 52242, USA
Genetics 140:207-17. 1995..We propose that fs (1) Yb acts as an ovary-specific factor that determines follicle cell fate...
- Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetaeM Van Doren
Department of Biology and Center for Molecular Genetics, University of California San Diego, La Jolla 92093 0322
Genes Dev 6:2592-605. 1992..Our results indicate that emc plays an essential early role in defining territories of bristle-forming potential...
- The primary sex determination signal of Drosophila acts at the level of transcriptionL N Keyes
Department of Biology, Princeton University, New Jersey 08544
Cell 68:933-43. 1992..The proteins produced from these early mRNAs then initiate the autoregulatory loop by directing the female-specific processing of transcripts from the late Sxl promoter...
- Point mutations in the Drosophila hairy gene demonstrate in vivo requirements for basic, helix-loop-helix, and WRPW domainsS M Wainwright
Department of Zoology, University of Oxford, England
Mol Cell Biol 12:2475-83. 1992..We show that the h protein in Drosophila virilis closely resembles that in D. melanogaster and includes completely conserved bHLH and WRPW domains...
- The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix proteinJ Garrell
Centro de Biologia Molecular, Universidad Autonoma de Madrid, Canto Blanco, Spain
Cell 61:39-48. 1990..These and other findings suggest the existence of a network of synergistic and antagonistic interactions, mediated by HLH proteins, that participates in the establishment of the neural fate...
- Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogasterD Bopp
Department of Molecular Biology, Princeton University, New Jersey 08544 1014
Genes Dev 5:403-15. 1991..The onset of Sxl expression in the germ line occurs later than that in the soma...
- Transcriptional activation by heterodimers of the achaete-scute and daughterless gene products of DrosophilaC V Cabrera
Marie Curie Research Institute, Oxted, Surrey, UK
EMBO J 10:2965-73. 1991The achaete-scute complex (AS-C) and the daughterless (da) genes encode helix-loop-helix proteins which have been shown to interact in vivo and to be required for neurogenesis...
- A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteinsC Murre
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Cell 56:777-83. 1989..Remarkable is the stringent conservation of hydrophobic residues present in both helices. We demonstrate that this new motif plays a crucial role in both dimerization and DNA binding...
- Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequenceC Murre
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Cell 58:537-44. 1989..A role of E12 and E47 in mammalian development, analogous to that of daughterless in Drosophila, is likely...
- Molecular characterization of daughterless, a Drosophila sex determination gene with multiple roles in developmentC Cronmiller
Department of Biology, Princeton University, New Jersey 08544 1003
Genes Dev 2:1666-76. 1988The daughterless (da) gene in Drosophila acts both maternally and zygotically to provide essential functions during development...
- The relationship of relative gene dose to the complex phenotype of the daughterless locus in DrosophilaC Cronmiller
Department of Biology, Princeton University, NJ 08544
Dev Genet 7:205-21. 1986The daughterless (da) gene provides an essential maternally supplied component for Drosophila sex determination and dosage compensation...
- Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activityA M Bailey
Department of Biology, University of California San Diego, La Jolla 92093 0366, USA
Genes Dev 9:2609-22. 1995..Our results establish Su(H) as a direct regulatory link between N receptor activity and the expression of E(spl)-C genes, extending the known linear structure of the N cell-cell signaling pathway...
- daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryoH Vaessin
Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
Development 120:935-45. 1994..genes of the achaete-scute complex AS-C (achaete (ac), scute (sc) and lethal of scute (l'sc)) and daughterless (da). The da protein dimerizes with AS-C products in vitro to form DNA-binding proteins...
- Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteinsZ Paroush
Laboratory of Developmental Genetics, University of Oxford, England
Cell 79:805-15. 1994....
- The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursorsA P Jarman
Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0724, USA
Development 119:19-29. 1993..asense differs from the other AS-C members in its expression pattern, regulation, mutant phenotype and some DNA-binding properities...
- The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domainA L Fisher
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021, USA
Mol Cell Biol 16:2670-7. 1996..These results directly demonstrate that Groucho family proteins are active transcriptional corepressors for Hairy-related proteins and are recruited by the 4-amino acid protein-protein interaction domain, WRPW...
- A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid systemP Alifragis
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, and Department of Biology, University of Crete, Heraklion, Greece
Proc Natl Acad Sci U S A 94:13099-104. 1997..fidelity of the system was established by its ability to closely reproduce the already documented interactions among Da, Ac, Sc, and Extramacrochaetae...
- The function of hairy-related bHLH repressor proteins in cell fate decisionsA Fisher
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York, USA
Bioessays 20:298-306. 1998..This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis...
- Relationships between extramacrochaetae and Notch signalling in Drosophila wing developmentA Baonza
Centro de Biologia Molecular, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
Development 127:2383-93. 2000..We propose that at least during vein differentiation and wing margin formation, extramacrochaetae is regulated by Notch and collaborates with other Notch-downstream genes such as Enhancer of split-m(beta)...
- Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm developmentI Castanon
Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Development 128:3145-59. 2001..Moreover, this work provides a paradigm for understanding how the same protein controls a sequence of events within a single lineage...
- Emc, a negative HLH regulator with multiple functions in Drosophila developmentS Campuzano
Centro de Biologia Molecular Severo Ochoa, Cantoblanco, 28049 Madrid, Spain
Oncogene 20:8299-307. 2001..However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation...
- A Twist in fate: evolutionary comparison of Twist structure and functionIrinka Castanon
Program in Molecular Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Gene 287:11-22. 2002..Conserved principles and the molecular mechanisms underlying them are discussed...
- Wingless blocks bristle formation and morphogenetic furrow progression in the eye through repression of DaughterlessKenneth M Cadigan
Howard Hughes Medical Institute and the Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, Stanford, California 94305, USA
Development 129:3393-402. 2002..These results are summarized in a model where daughterless is a major, but probably not the only, target of wingless action in the eye...
- The role of class I HLH genes in neural development--have they been overlooked?Julian Ik Tsen Heng
Brain Development Group, The Howard Florey Institute, University of Melbourne, Parkville VIC 3010, Melbourne Australia
Bioessays 25:709-16. 2003..This essay supports this possibility, in addition to putting forward the hypothesis that, outside their general dimerisation activity, class I genes have independent roles in regulating neurogenesis...
- EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulationPetra I zur Lage
Division of Biomedical Sciences, Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
Dev Cell 7:687-96. 2004..This exemplifies a simple and general mechanism for regulating the transition from competence to cell fate commitment whereby a cell signal directly targets the autoregulation of a selector gene...
- Proneural basic helix-loop-helix proteins and epidermal growth factor receptor signaling coordinately regulate cell type specification and cdk inhibitor expression during developmentMadina J Sukhanova
Ben May Department for Cancer Research, The University of Chicago, 924 E 57th Street, Chicago, IL 60637, USA
Mol Cell Biol 27:2987-96. 2007..transcription factor Pointed (Pnt) and the proneural basic helix-loop-helix proteins Atonal (Ato) and Daughterless (Da)...
- Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STATTetsuo Yasugi
Laboratory of Pattern Formation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
Development 135:1471-80. 2008....
- Negative-feedback regulation of proneural proteins controls the timing of neural precursor divisionPao Ju Chang
Department of Life Science, Chang Gung University, 259 Wen Hwa 1st Road, Kwei Shan, Tao Yuan 333, Taiwan
Development 135:3021-30. 2008..As phyl is a direct transcriptional target of Ac and Sc, our data suggest that, in addition to mediating cell cycle arrest, proneural protein initiates a negative-feedback regulation to time the mitotic entry of neural precursors...
- Klumpfuss is involved in the determination of sensory organ precursors in DrosophilaMarkus Kaspar
Institute of Genetics, Heinrich Heine University Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
Dev Biol 324:177-91. 2008..We present a detailed structure function analysis that identifies functionally important domains within Klu...
- The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eyeAbhishek Bhattacharya
Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Dev Biol 327:288-300. 2009..A model is proposed in which Extramacrochaetae acts in parallel to or as a feed-forward regulator of the E(spl)-Complex to promote Notch signaling in particular cellular contexts...
- A microRNA imparts robustness against environmental fluctuation during developmentXin Li
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
Cell 137:273-82. 2009..We suggest that some conserved microRNAs like miR-7 may enter into novel genetic relationships to buffer developmental programs against variation and impart robustness to diverse regulatory networks...
- Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regionsStewart MacArthur
Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
Genome Biol 10:R80. 2009....
- A network of broadly expressed HLH genes regulates tissue-specific cell fatesAbhishek Bhattacharya
Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Cell 147:881-92. 2011..In Drosophila, a cross-interacting regulatory network links expression of the E protein Daughterless (Da), which heterodimerizes with bHLH proteins to activate them, with expression of the Id protein Extramacrochaetae (..
- The two Tribolium E(spl) genes show evolutionarily conserved expression and function during embryonic neurogenesisKristina Kux
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas and Department of Biology, University of Crete, Heraklion, Crete, Greece
Mech Dev 130:207-25. 2013..A number of other activities have been evolutionarily conserved, most notably their ability to interact with proneural proteins Scute and Daughterless...
- Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiationMiho Tanaka-Matakatsu
Ben May Department for Cancer Research, The University of Chicago, 929 E 57th Street, Chicago, IL 60637, USA
Dev Biol 392:256-65. 2014..In this manuscript, we show that a linked dimer of Daughterless (Da), the only Drosophila class I bHLH protein, activates Atonal (Ato) expression and retinal neuron differentiation ..
- Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: epidermogenesis or neurogenesisJ A Campos-Ortega
Institut für Entwicklungsphysiologie, Universitat zu Koln, Federal Republic of Germany
Eur J Biochem 190:1-10. 1990....
- daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complexM Caudy
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143
Cell 55:1061-7. 1988daughterless (da) has multiple functions in Drosophila embryonic development: maternal da activity is necessary for proper sex determination, and zygotic da activity is necessary for formation of the peripheral nervous system...
- The Drosophila sex determination gene daughterless has different functions in the germ line versus the somaC Cronmiller
Cell 48:479-87. 1987As a regulator of the female-specific gene Sxl, da+ provides an essential maternal component in the control of sex determination and dosage compensation; nevertheless, neither the maternal nor zygotic phenotypes of the original mutant da ..
- The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during developmentC Cronmiller
Department of Biology, University of Virginia, Charlottesville 22901
Mech Dev 42:159-69. 1993The daughterless (da) gene in Drosophila functions in the regulation of at least three significant developmental pathways: sex determination, neurogenesis and oogenesis...
- The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genesU Hinz
Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
Cell 76:77-87. 1994..Finally, the bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition...
- Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in DrosophilaS González-Crespo
Department of Biology, University of California at San Diego, La Jolla 92093 0322
Genes Dev 7:1703-13. 1993..Evidence is also presented that dl-HLH interactions involve the direct physical association of these proteins in solution mediated by the rel and HLH domains. We discuss the striking parallels in mesoderm formation and sex determination...
- asense is a Drosophila neural precursor gene and is capable of initiating sense organ formationM Brand
Howard Huges Medical Institute, University of California, San Francisco, CA 94143 0724, USA
Development 119:1-17. 1993..Our studies therefore serve as a cautionary note for the inference of normal gene function based on the gain-of-function phenotype after ectopic expression...
- Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in DrosophilaR Nolo
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 102:349-62. 2000..Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs...
- Two modes of recruitment of E(spl) repressors onto target genesNikolaos Giagtzoglou
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Greece
Development 130:259-70. 2003..Irrespective of whether E(spl) are recruited via direct DNA binding or interaction with proneural proteins, the co-repressor Groucho is always needed for target gene repression...
- Role of the Sc C terminus in transcriptional activation and E(spl) repressor recruitmentNikolaos Giagtzoglou
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Vasilika Vouton, Heraklion, GR 71110, Greece
J Biol Chem 280:1299-305. 2005..In vivo, the Sc C-terminal domain is required for E(spl) recruitment in an enhancer context-dependent fashion, suggesting that in some enhancers alternative interaction surfaces can be used to recruit E(spl) proteins...
- Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing marginHamed Jafar-Nejad
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Development 133:1683-92. 2006..Our data indicate that transcription factors other than bHLH proteins can also perform the proneural function in the Drosophila peripheral nervous system...
- A shared enhancer controls a temporal switch between promoters during Drosophila primary sex determinationAlejandra N González
Department of Biology, Texas A and M University, College Station, TX 77843, USA
Proc Natl Acad Sci U S A 105:18436-41. 2008....
- Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repressionIoanna Zarifi
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, and Department of Biology, University of Crete, Heraklion, Crete, Greece
Mol Cell Biol 32:4534-48. 2012..Daughterless (Da) is the sole E protein in Drosophila and is ubiquitously expressed...
- The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexesM Van Doren
Department of Biology, University of California San Diego, La Jolla 92093 0322
Development 113:245-55. 1991..Proteins encoded by the daughterless (da) gene and three genes of the achaete-scute complex (AS-C) act positively in the determination of the sensory organ ..
- daughterless is required for Drosophila photoreceptor cell determination, eye morphogenesis, and cell cycle progressionN L Brown
Howard Hughes Medical Institute and Bock Laboratories, Madison, Wisconsin 53706, USA
Dev Biol 179:65-78. 1996..basic helix-loop-helix (bHLH) transcription factors that dimerize in vitro with another bHLH protein, daughterless (da)...
- Evolution of neural precursor selection: functional divergence of proneural proteinsXiao Jiang Quan
Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, Belgium
Development 131:1679-89. 2004..These data suggest an evolutionary divergence in the mechanisms of NPC selection between protostomes and deuterostomes...
- Direct downstream targets of proneural activators in the imaginal disc include genes involved in lateral inhibitory signalingA Singson
Department of Biology, University of California San Diego, La Jolla 92093 0322
Genes Dev 8:2058-71. 1994..Thus, one of the earliest steps in adult peripheral neurogenesis is the direct activation by proneural proteins of genes involved in restricting the expression of the SOP cell fate...
- Protein-protein interactions among components of the Drosophila primary sex determination signalY Liu
Department of Biology, Syracuse University, NY 13244, USA
Mol Gen Genet 248:182-9. 1995..g., deadpan (dpn)], and (3) maternal factors [e.g., daughterless (da)]...
- A genetic screen for elements of the network that regulates neurogenesis in DrosophilaG Röttgen
Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
Mol Gen Genet 257:442-51. 1998..Besides mutations in genes expected to modify the phenotype, we have isolated mutations in six genes not known so far to be involved in neurogenesis...
- batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factorM Faucheux
Laboratoire d Embryologie Moleculaire et Experimentale, Chromatine et Développement, CNRS ESA 8080, Universite Paris Sud, Orsay, France
Mol Cell Biol 23:1181-95. 2003..Together, our results suggest that batman belongs to a subset of the Polycomb/trithorax group of genes that includes Trithorax-like, whose products are involved in both activation and repression of homeotic genes...
- The bHLH factors extramacrochaetae and daughterless control cell cycle in Drosophila imaginal discs through the transcriptional regulation of the Cdc25 phosphatase stringIrene Andrade-Zapata
Centro de Biologia Molecular Severo Ochoa CSIC UAM, Madrid, Spain
PLoS Genet 10:e1004233. 2014..The E protein orthologue Daughterless (Da) and the Id orthologue Extramacrochaetae (Emc) are the only members of these classes of bHLH proteins in Drosophila...
- A re-examination of the selection of the sensory organ precursor of the bristle sensilla of Drosophila melanogasterTobias Troost
Institut fuer Genetik, Heinrich Heine Universitaet Duesseldorf, Duesseldorf, Germany
PLoS Genet 11:e1004911. 2015..They encode tissue specific bHLH proteins that form functional heterodimers with the bHLH protein Daughterless (Da)...
- Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferationCarrie M Spratford
Department of Biology, Indiana University, Bloomington, IN 47405, USA Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
Development 142:2058-68. 2015..Notch signaling is devoted to blocking the growth-suppressing activity of the bHLH DNA-binding protein Daughterless (Da)...
- HLH54F is required for the specification and migration of longitudinal gut muscle founders from the caudal mesoderm of DrosophilaAfshan Ismat
Mount Sinai School of Medicine, Department of Molecular, Cell and Developmental Biology currently Developmental and Regenerative Biology, Box 1020, Mount Sinai School of Medicine, New York, NY 10029, USA
Development 137:3107-17. 2010..We conclude that HLH54F is the earliest specific regulator of CVM development and that it plays a pivotal role in all major aspects of development and differentiation of this largely twist-independent population of mesodermal cells...
- Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repressionMona Abed
Cancer and Vascular Biology Research Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
EMBO J 30:1289-301. 2011..As Gro/TLE proteins are conserved universal corepressors, this may be a general paradigm used to regulate the Gro/TLE corepressors in other developmental processes...
- Drosophila lilliputian is required for proneural gene expression in retinal developmentGinnene M Distefano
Department of Biology, Drexel University, Philadelphia, Pennsylvania 19104, USA
Dev Dyn 241:553-62. 2012..expression of the basic helix-loop-helix (bHLH) proneural transcription factors Atonal (Ato) and Daughterless (Da)...
- Evidence for a set of closely linked autosomal genes that interact with sex-chromosome heterochromatin in Drosophila melanogasterL Sandler
Genetics 86:567-82. 1977..The nature of this interaction and possible reasons for the existence of the cluster of autosomal genes are discussed...
- Sex determination and differentiation in invertebrates: Drosophila and Caenorhabditis elegansM McKeown
Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
Curr Opin Cell Biol 4:948-54. 1992..We are now gaining an understanding of the molecular mechanisms governing the largely post-transcriptional regulation of the intermediate steps in these cascades...
- The segmentation gene runt is needed to activate Sex-lethal, a gene that controls sex determination and dosage compensation in DrosophilaM Torres
Centro de Investigaciones Biologicas, Madrid, Spain
Genet Res 59:189-98. 1992..We conclude that runt is needed for the initial step of Sex-lethal activation, but does not have a major role as an X-counting element...
- Calmodulin transcription is limited to the nervous system during Drosophila embryogenesisG E Kovalick
Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005
Dev Biol 150:33-46. 1992..The calmodulin transcription pattern is altered in embryos mutant for each of these loci, suggesting that regulation by these genes, either directly or indirectly, is taking place...
- The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethalJ B Duffy
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
Genes Dev 5:2176-87. 1991..runt is distinguished from previously identified regulators of Sxl by its nonuniform role and by the absence of an identifiable helix-loop-helix (HLH) motif, indicating that the activation of Sxl is not controlled solely by HLH proteins...
- Specification of cell fate in the developing eye of DrosophilaK Basler
Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, N Y 10032
Bioessays 13:621-31. 1991..Genetic dissection of this pathway should therefore identify components of a signalling cascade activated by a tyrosine kinase...
- Role of helix-loop-helix proteins in Drosophila neurogenesisH Vaessin
Howard Hughes Medical Institute, University of California, San Francisco 94143
Cold Spring Harb Symp Quant Biol 55:239-45. 1990
- Autoregulatory functioning of a Drosophila gene product that establish es and maintains the sexually determined stateT W Cline
Genetics 107:231-77. 1984..Some of these sex-transforming Sxl mutants do not require the maternally produced da(+) activity that is normally essential for the functioning of zygotic Sxl alleles...
- Diploidy of Drosophila imaginal cells is maintained by a transcriptional repressor encoded by escargotN Fuse
Graduate University for Advanced Studies, National Institute of Genetics, Shizuoka ken, Japan
Genes Dev 8:2270-81. 1994..Ectopic expression of esg in the salivary glands inhibits endoreplication of DNA. These results suggest that esg is involved in transcriptional inhibition of genes required for endoreplication...
- Polytene chromosomes of monogenic and amphogenic Chrysomya species (Calliphoridae, Diptera): analysis of banding patterns and in situ hybridization with Drosophila sex determining gene sequencesS Puchalla
Zoologisches Institut, Universitat Kiel, Germany
Chromosoma 103:16-30. 1994..and amphogenic Chrysomya species contains sequences homologous to the maternal sex determining gene daughterless (da). Homology to the zygotic gene Sex-lethal (Sxl) of Drosophila is detected in band 39A1 on chromosome 5 of C...
- A dual role for the protein kinase shaggy in the repression of achaete-scuteP Simpson
Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
Dev Suppl . 1993..shaggy is required downstream of Notch for transduction of the inhibitory signal. This second role of shaggy may be due to modulation of enzymatic activity during signalling...
- Sex determination in Drosophila melanogaster: X-linked genes involved in the initial step of sex-lethal activationL Sanchez
Centro de Investigaciones Biologicas, Velazquez, Madrid, Spain
Dev Genet 15:251-64. 1994..We review these data and present new data on two more regions of the X chromosome that define other genes needed for Sxl activation. In addition, we report on the interaction between some of the genes regulating Sxl activation...
- achaete-scute feminizing activities and Drosophila sex determinationS M Parkhurst
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Development 117:737-49. 1993..Detailed examination of Sxl expression in rescued embryos suggests that female cells may be viable in the absence of detectable Sxl protein expression...
- A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogasterN J Clegg
Department of Zoology, University of British Columbia, Canada
Genome 36:676-85. 1993..The phenotypes of our mutants are consistent with a role for Cdc2 in cell proliferation; however, we did not observe any perturbation of the endoreduplication cycle associated with the acquisition of polyteny...
- Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in DrosophilaP Heitzler
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, Strasbourg, France
Development 122:161-71. 1996..Thus there is a regulatory loop between Notch and Delta that is under the transcriptional control of the E(spl)-C and AS-C genes...
- Proneural and neurogenic genes control specification and Morphogenesis of stomatogastric nerve cell precursors in DrosophilaV Hartenstein
Department of Biology, University of California, Los Angeles 90095 1606, USA
Dev Biol 173:213-27. 1996....
- Drosophila differentiation genes instrumental in tumor suppressionE Gateff
Institut fur Genetik, Johannes Gutenberg Universitat, Mainz, Germany
Int J Dev Biol 40:149-56. 1996....
- Regulatory interactions during early neurogenesis in DrosophilaB Hassan
Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus 43210, USA
Dev Genet 18:18-27. 1996..While lineage identity genes allow the various lineages to acquire specific identities, neuronal precursor genes presumably regulate functional and developmental characteristics common to all neuronal precursor cells...
- Myc and Max homologs in DrosophilaP Gallant
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle WA 98104, USA
Science 274:1523-7. 1996..These findings indicate a potential role for Myc in germ cell development and set the stage for genetic analysis of Myc and Max...
- Groucho-dependent and -independent repression activities of Runt domain proteinsB D Aronson
Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, 11794 5215, USA
Mol Cell Biol 17:5581-7. 1997..Unlike other transcriptional regulatory proteins that interact with Groucho, Runt domain proteins are known to activate transcription. This suggests that the Runt domain protein-Groucho interaction may be regulated...
- Nucleotide compositional constraints on genomes generate alanine-, glycine-, and proline-rich structures in transcription factorsY Nakachi
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
Mol Biol Evol 14:1042-9. 1997..Furthermore, reptile class III POU sequences revealed no evolutionary directionality increasing the GC contents from cold- to warm-blooded vertebrates...
- Control of cell lineage-specific development and transcription by bHLH-PAS proteinsS T Crews
Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7260 USA
Genes Dev 12:607-20. 1998
- Krüppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of DrosophilaM Hoch
Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, D 37077 Gottingen, Germany
EMBO J 17:5766-75. 1998....
- Evolutionary conservation of MyoD function and differential utilization of E proteinsJ M Zhang
Laboratory of Biochemistry, NCI, National Institutes of Health, Bethesda, Maryland, 20892, USA
Dev Biol 208:465-72. 1999..elegans CeMyoD loss-of-function mutation. These results demonstrate a remarkable degree of functional conservation of these myogenic factors despite differences in E-protein interactions...
- The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous systemM L Huang
Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
Neuron 25:57-67. 2000..Amos interacts with the ubiquitously expressed Daughter-less protein in vivo and in vitro. Our final misexpression experiments suggest that a domain located outside the DNA-binding domain of Amos determines the MD neuronal specificity...
- amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozengeS E Goulding
Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
Neuron 25:69-78. 2000..We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS...
- Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouseE Segev
Department of Cell and Animal Biology, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
Mech Dev 106:197-202. 2001..In contrast to the brain, expression in the spinal cord was limited to the embryonic stages...
- The Drosophila daughterless gene autoregulates and is controlled by both positive and negative cis regulationJ E Smith
Department of Biology, Gilmer Hall, University of Virginia, P O Box 400328, Charlottesville, VA 22904 4328, USA
Development 128:4705-14. 2001As the only class I helix-loop-helix transcription factor in Drosophila, Daughterless (Da) has generally been regarded as a ubiquitously expressed binding partner for other developmentally regulated bHLH transcription factors...
- Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiationFrancoise Chanut
Department of Anatomy, University of California, San Francisco, California 94143, USA
Genetics 160:623-35. 2002..We show that Roi can rescue the retinal developmental defect of ato1 mutants and speculate that amos substitutes for some of ato's function in the eye or activates a residual function of the ato1 allele...
- senseless is necessary for the survival of embryonic salivary glands in DrosophilaVidya Chandrasekaran
Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, CA 94720, USA
Development 130:4719-28. 2003..The expression of sens is maintained in the salivary glands by fkh and by daughterless (da), a bHLH family member...
- Genetic complexity underlying hybrid male sterility in DrosophilaKyoichi Sawamura
Drosophila Genetic Resource Center, Kyoto Institute of Technology, Kyoto 616 8354, Japan
Genetics 166:789-96. 2004..Such an epistatic view, even in the less-related species, suggests that the genetic complexity is special to hybrid male sterility...
- Senseless physically interacts with proneural proteins and functions as a transcriptional co-activatorMelih Acar
Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
Development 133:1979-89. 2006....
- Two closely linked mutations in Drosophila melanogaster that are lethal to opposite sexes and interact with daughterlessT W Cline
Genetics 90:683-98. 1978..repect, particularly with regard to their interaction with maternal effect of the autosomal mutation, daughterless (da). Females that are homozygous for da produce defective eggs that cannot support female (XX) development...
- How do germ cells choose their sex? Drosophila as a paradigmM Steinmann-Zwicky
Zoological Institute, University of Zurich, Switzerland
Bioessays 14:513-8. 1992..Some of the genes that are involved in germ line sex determination have been identified. In other species, including vertebrates, inductive signals are commonly used to determine the sex of germ cells...
- Evidence of a dual function in fl(2)d, a gene needed for Sex-lethal expression in Drosophila melanogasterB Granadino
Centro de Investigaciones Biologicas, Madrid, Spain
Genetics 130:597-612. 1992..There is no female synergistic lethality between mutations at fl(2)d and neither at sc or da. However, the female synergistic lethality between mutations at Sxl and either sc or da is increased by fl(2)d ..
- The helix-loop-helix domain: a common motif for bristles, muscles and sexJ Garrell
Centro de Biologia Molecular, CSIC UAM, Madrid, Spain
Bioessays 13:493-8. 1991..These structural properties provide a molecular mechanism to explain the synergistic and antagonistic functional relations among the HLH encoding genes that control several developmental pathways...
- High-Volume Confocal Imaging SystemStephen Crews; Fiscal Year: 2005..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
- Genetics of Alcohol Sensitivity in DrosophilaTrudy Mackay; Fiscal Year: 2006....
- TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILAKenneth Cadigan; Fiscal Year: 2005..We have identified the daughterless (da) gene as potential direct target of Wg-dependent bristle inhibition in the eye...
- Identification of new Wnt signaling componentsKenneth Cadigan; Fiscal Year: 2006..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
- Molecular Genetics of Midline Glial DevelopmentStephen T Crews; Fiscal Year: 2010..abstract_text> ..
- PLASMIDES FOR THE EXPRESSION OF FILAMENTOUS HAEMAGGLUTININ (FHA) AND HOSTS THEREFORPatent Number: WO9218624-A1; Date:1992-10-29