cyc

Summary

Gene Symbol: cyc
Description: cycle
Alias: BMAL1, Bmal1, CG8727, CYC, CYCLE, Cyc, Cycle, Dmel\CG8727, MOP3, Mop3, TGO_CYC, bHLHe7, bMAL1, dBMAL, dBMAL1, dBma1, dBmal, dCYC, dbmal, dbmal1, CG8727 gene product from transcript CG8727-RA, CG8727-PA, brain and muscle ARNT-like 1, cyc-PA
Species: fruit fly

Top Publications

  1. ncbi Noncircadian regulation and function of clock genes period and timeless in oogenesis of Drosophila melanogaster
    L M Beaver
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    J Biol Rhythms 18:463-72. 2003
  2. ncbi A sleep-promoting role for the Drosophila serotonin receptor 1A
    Quan Yuan
    Howard Hughes Medical Institute, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 16:1051-62. 2006
  3. pmc Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein
    Eun Young Kim
    Department of Molecular Biology and Biochemistry, Rutgers University, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:6178-83. 2006
  4. pmc PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription
    Wangjie Yu
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Genes Dev 20:723-33. 2006
  5. ncbi The circadian timekeeping system of Drosophila
    Paul E Hardin
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, Texas 77204 5001, USA
    Curr Biol 15:R714-22. 2005
  6. pmc The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    Shawn A Cyran
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 25:5430-7. 2005
  7. ncbi Regulation of copulation duration by period and timeless in Drosophila melanogaster
    Laura M Beaver
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    Curr Biol 14:1492-7. 2004
  8. ncbi Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila
    Shintaro Tanoue
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, TX 77204 USA
    Curr Biol 14:638-49. 2004
  9. ncbi Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A
    Sriram Sathyanarayanan
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 116:603-15. 2004
  10. ncbi The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
    Pipat Nawathean
    Howard Hughes Medical Institute, Biology Department MS 008, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Mol Cell 13:213-23. 2004

Research Grants

  1. IDENTIFICATION AND ANALYSIS OF CLOCK CONTROLLED GENES
    Jennifer Loros; Fiscal Year: 2007
  2. GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCK
    Jay Dunlap; Fiscal Year: 2007
  3. PREPHASE I GENE/IMMUNE THERAPY OF MALIGNANT BRAIN TUMOR
    HASSAN FATHALLAH SHAYKH; Fiscal Year: 2001
  4. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
  5. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2009
  6. Formation of an Olfactory Sensory Map
    LESLIE VOSSHALL; Fiscal Year: 2006
  7. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
  8. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011
  9. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
  10. A transgenic model of ocular inflammation
    Russell Van Gelder; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications100

  1. ncbi Noncircadian regulation and function of clock genes period and timeless in oogenesis of Drosophila melanogaster
    L M Beaver
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    J Biol Rhythms 18:463-72. 2003
    ..TIM and PER in the ovary are affected neither by light nor by the lack of clock-positive elements Clock (Clk) and cycle (cyc)...
  2. ncbi A sleep-promoting role for the Drosophila serotonin receptor 1A
    Quan Yuan
    Howard Hughes Medical Institute, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 16:1051-62. 2006
    ..Serotonin is an important neurotransmitter known to affect many behaviors, but its role in sleep remains controversial...
  3. pmc Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein
    Eun Young Kim
    Department of Molecular Biology and Biochemistry, Rutgers University, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:6178-83. 2006
    ..A negative feedback loop wherein PER directly inhibits the transcriptional activity of the CLOCK-CYCLE (CLK-CYC) heterodimer is central to the generation of molecular rhythms and normal progression of the clock in ..
  4. pmc PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription
    Wangjie Yu
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
    Genes Dev 20:723-33. 2006
    Transcriptional activation by CLOCK-CYCLE (CLK-CYC) heterodimers and repression by PERIOD-TIMELESS (PER-TIM) heterodimers are essential for circadian oscillator function in Drosophila...
  5. ncbi The circadian timekeeping system of Drosophila
    Paul E Hardin
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, Texas 77204 5001, USA
    Curr Biol 15:R714-22. 2005
    ..I will also discuss where work remains to be done to give a comprehensive picture of the circadian clock in Drosophila and likely many other organisms...
  6. pmc The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period
    Shawn A Cyran
    Department of Biology, New York University, New York, New York 10003, USA
    J Neurosci 25:5430-7. 2005
    ..Here, we show that these effects of SGG on PER nuclear accumulation require TIM. We propose a revised clock model that incorporates this tight kinase regulation of PER and TIM nuclear entry...
  7. ncbi Regulation of copulation duration by period and timeless in Drosophila melanogaster
    Laura M Beaver
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    Curr Biol 14:1492-7. 2004
    ..Mutations in clock genes in Drosophila melanogaster, period (per), timeless (tim), Clock (Clk), and cycle (cyc), produce multiple phenotypes associated with physiology, behavior, development, and morphology...
  8. ncbi Circadian clocks in antennal neurons are necessary and sufficient for olfaction rhythms in Drosophila
    Shintaro Tanoue
    Department of Biology and Biochemistry, University of Houston, 4800 Calhoun Road, Houston, TX 77204 USA
    Curr Biol 14:638-49. 2004
    ..We previously showed that peripheral oscillators are required to mediate rhythmic olfactory responses in the antenna, but the identity and relative autonomy of these peripheral oscillators has not been defined...
  9. ncbi Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A
    Sriram Sathyanarayanan
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 116:603-15. 2004
    ..PP2A also affects PER phosphorylation in vitro and in vivo. We propose that the posttranslational mechanisms that drive cycling of PER require the rhythmic expression of PP2A...
  10. ncbi The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
    Pipat Nawathean
    Howard Hughes Medical Institute, Biology Department MS 008, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Mol Cell 13:213-23. 2004
    ..This interpretation suggests further that the circadian regulation of PER nuclear localization in flies reflects changes in PER transcriptional activity rather than in PER nuclear import or export activity...
  11. pmc Sex- and clock-controlled expression of the neuropeptide F gene in Drosophila
    Gyunghee Lee
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA
    Proc Natl Acad Sci U S A 103:12580-5. 2006
    ..Such ms-npf expression in the dorsolateral neurons is absent in arrhythmic Clock(Jrk) and cycle(02) mutants, suggesting that npf is under dual regulation by circadian and sex-determining factors...
  12. pmc Drosophila free-running rhythms require intercellular communication
    Ying Peng
    Department of Biology, Brandeis University, Waltham, Massachusetts, USA
    PLoS Biol 1:E13. 2003
    ..The cooperative function of this network appears to be necessary for maintaining robust molecular oscillations in DD and is the basis of sustained circadian locomotor activity rhythms...
  13. ncbi The network of time: understanding the molecular circadian system
    Till Roenneberg
    Institute for Medical Psychology, University of Munich, Goethestrasse 31, 80336 Munich, Germany
    Curr Biol 13:R198-207. 2003
    ....
  14. ncbi vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock
    Shawn A Cyran
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 112:329-41. 2003
    The Drosophila circadian clock consists of two interlocked transcriptional feedback loops. In one loop, dCLOCK/CYCLE activates period expression, and PERIOD protein then inhibits dCLOCK/CYCLE activity...
  15. ncbi Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim
    T K Darlington
    Department of Cell Biology and NSF Center for Biological Timing, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 280:1599-603. 1998
    ..dCLOCK functioned as a heterodimer with a Drosophila homolog of BMAL1. These proteins acted through an E-box sequence in the period promoter...
  16. ncbi VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator
    Nicholas R J Glossop
    Department of Biology and Biochemistry, University of Houston, 369 Science and Research Bldg 2, Houston, TX 77204, USA
    Neuron 37:249-61. 2003
    ..Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the ..
  17. ncbi Genetic analysis of the circadian system in Drosophila melanogaster and mammals
    Ralf Stanewsky
    Universitat Regensburg, Institut fur Zoologie, Lehrstuhl für Entwicklungsbiologie, Universitatsstrasse 31, 93040 Regensburg, Germany
    J Neurobiol 54:111-47. 2003
    ..This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks...
  18. ncbi A role for casein kinase 2alpha in the Drosophila circadian clock
    Jui Ming Lin
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Nature 420:816-20. 2002
    ..For example, the Drosophila proteins Clock (Clk) and Cycle (Cyc) activate transcription of period (per) and timeless (tim)...
  19. ncbi Circadian rhythms from flies to human
    Satchidananda Panda
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 417:329-35. 2002
    ..To gain the initial insights into circadian mechanisms, researchers turned to genetically tractable model organisms such as Drosophila...
  20. ncbi Stress response genes protect against lethal effects of sleep deprivation in Drosophila
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, California 92121, USA
    Nature 417:287-91. 2002
    ..in the canonical loss-of-function clock mutants period (per(01)), timeless (tim(01)), clock (Clk(jrk)) and cycle (cyc(01))...
  21. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
    ..We propose that the input of neuronal clocks and clocks in metabolic tissues is coordinated to provide effective energy homeostasis...
  22. pmc Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression
    Katharine Compton Abruzzi
    Howard Hughes Medical Institute, National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Genes Dev 25:2374-86. 2011
    ..CLK binding cycles on at least 800 sites with maximal binding in the early night. The CLK partner protein CYCLE (CYC) is on most of these sites...
  23. pmc The sleep-feeding conflict: Understanding behavioral integration through genetic analysis in Drosophila
    Daniel M McDonald
    Department of Biology, New York University, New York, NY 10003, USA
    Aging (Albany NY) 2:519-22. 2010
    ..Current Biology we showed that flies, like mammals, suppress sleep when starved and identified the genes Clock and cycle as regulators of sleep during starvation...
  24. pmc Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila
    Elzbieta Kula-Eversole
    Howard Hughes Medical Institute, National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 107:13497-502. 2010
    ..Many of these cycling l-LNv mRNAs are well expressed but do not cycle or cycle much less well elsewhere in heads...
  25. pmc Clock and cycle limit starvation-induced sleep loss in Drosophila
    Alex C Keene
    Biology Department, New York University, New York, NY 10003, USA
    Curr Biol 20:1209-15. 2010
    ..The circadian clock genes Clock (Clk) and cycle (cyc) are critical for proper sleep suppression during starvation...
  26. pmc Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway
    Laura Michelle Beaver
    Department of Zoology, Oregon State University, Corvallis, Oregon 97331, USA
    Toxicol Sci 115:513-20. 2010
    ..In Drosophila melanogaster, the circadian clock consists of positive elements encoded by cycle (cyc) and Clock (Clk) and negative elements encoded by period (per) and timeless (tim) genes...
  27. pmc Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA
    Jerome S Menet
    Department of Biology, Howard Hughes Medical Institute, National Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    Genes Dev 24:358-67. 2010
    ..here in the Drosophila model two different mechanisms by which the circadian repressor PERIOD (PER) inhibits CLOCK/CYCLE (CLK/CYC)-mediated transcription...
  28. pmc Regulation of gustatory physiology and appetitive behavior by the Drosophila circadian clock
    Abhishek Chatterjee
    Department of Biology and Center for Biological Clocks Research, Texas A and M University, College Station, TX 77843 3258, USA
    Curr Biol 20:300-9. 2010
    ..Here we examine gustatory physiology, tastant-evoked appetitive behavior, and food ingestion to understand clock-dependent regulation of the Drosophila gustatory system...
  29. pmc Mathematical model of the Drosophila circadian clock: loop regulation and transcriptional integration
    Hassan M Fathallah-Shaykh
    The University of Alabama at Birmingham, Department of Neurology, The UAB Comprehensive Neuroscience Center, Birmingham, Alabama, USA
    Biophys J 97:2399-408. 2009
    ..The clock-cycle dimer (CLK-CYC) and its homolog, CLK-BMAL1, are key transcriptional activators of central components of the Drosophila and mammalian circadian networks, ..
  30. pmc Selective entrainment of the Drosophila circadian clock to daily gradients in environmental temperature
    Jake Currie
    University of Virginia, Department of Biology, Charlottesville, VA, USA
    BMC Biol 7:49. 2009
    ..This study identifies key properties of this process...
  31. ncbi Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster
    Joan C Hendricks
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biol Rhythms 18:12-25. 2003
    ..Only the cycle (cyc01) and Clock (Clk(Jrk)) mutants had abnormalities that mapped to the mutant locus, namely, decreased ..
  32. pmc Circadian transcription contributes to core period determination in Drosophila
    Sebastian Kadener
    Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
    PLoS Biol 6:e119. 2008
    The Clock-Cycle (CLK-CYC) heterodimer constitutes a key circadian transcription complex in Drosophila. CYC has a DNA-binding domain but lacks an activation domain...
  33. ncbi Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP
    Hsiu Cheng Hung
    Biochemie Zentrum Heidelberg, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    J Biol Chem 282:31349-57. 2007
    ..activities, including metabolism, neuronal activity, and cell proliferation in synchrony with the environmental cycle of day and night...
  34. pmc A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock
    Akira Matsumoto
    Laboratory for Systems Biology, Center for Developmental Biology, RIKEN, Kobe, Hyogo, Japan
    Genes Dev 21:1687-700. 2007
    ..cwo is rhythmically expressed and directly regulated by CLK-CYC through canonical E-box sequences...
  35. pmc Interaction between sleep and the immune response in Drosophila: a role for the NFkappaB relish
    Julie A Williams
    Center for Advanced Biotechnology and Medicine and Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Piscataway 08854 5603, USA
    Sleep 30:389-400. 2007
    ..The Drosophila model for sleep provides a powerful system to identify and test the role of sleep-relevant molecules...
  36. pmc Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster
    Chunghun Lim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, South Korea
    Mol Cell Biol 27:4876-90. 2007
    ..we show that CREB-binding protein (CBP) participates in the transcriptional regulation of the Drosophila CLOCK/CYCLE (dCLK/CYC) heterodimer...
  37. ncbi Induction of Drosophila behavioral and molecular circadian rhythms by temperature steps in constant light
    Taishi Yoshii
    Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    J Biol Rhythms 22:103-14. 2007
    ..Arrhythmic per(01) , tim( 01) , dClk(Jrk) , and cyc(01) mutant flies failed to show the rhythm after the step-down, suggesting that per, tim, dClk, and cyc are ..
  38. pmc Identification of a biomarker for sleep drive in flies and humans
    Laurent Seugnet
    Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8108, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:19913-8. 2006
    ..These data indicate that the fly is relevant for human sleep research and represents a first step in developing an effective method for detecting sleepiness in vulnerable populations...
  39. ncbi Circadian oscillators of Drosophila and mammals
    Wangjie Yu
    Department of Biology and Center for Research on Biological Clocks, Texas A and M University, College Station, TX 77843 3258, USA
    J Cell Sci 119:4793-5. 2006
  40. ncbi Waking experience affects sleep need in Drosophila
    Indrani Ganguly-Fitzgerald
    Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92101, USA
    Science 313:1775-81. 2006
    ..Furthermore, this experience-dependent plasticity in sleep need is subserved by the dopaminergic and adenosine 3',5'-monophosphate signaling pathways and a particular subset of 17 long-term memory genes...
  41. ncbi Interlocked feedback loops within the Drosophila circadian oscillator
    N R Glossop
    Department of Biology and Biochemistry and Biological Clocks Program, University of Houston, Houston, TX 77204 5513, USA
    Science 286:766-8. 1999
    ..dClk mRNA cycling is shown here to be regulated by PERIOD-TIMELESS (PER-TIM)-mediated release of dCLK- and CYCLE (CYC)-dependent repression...
  42. ncbi Neuroanatomy of cells expressing clock genes in Drosophila: transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections
    M Kaneko
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Comp Neurol 422:66-94. 2000
    ....
  43. ncbi The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior
    L Sarov-Blat
    Howard Hughes Medical Institute, National Science Foundation, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Cell 101:647-56. 2000
    ..We propose that to participates in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activities...
  44. pmc Differential regulation of circadian pacemaker output by separate clock genes in Drosophila
    J H Park
    Department of Biology and National Science Foundation Center for Biological Timing, and Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 97:3608-13. 2000
    ..Mutations in the transcription factors CLOCK and CYCLE severely diminish pdf RNA and neuropeptide (PDF) levels in a single cluster of clock-gene-expressing brain cells, ..
  45. ncbi dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex
    K Bae
    Graduate Program in Microbiology, Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA
    J Neurosci 20:1746-53. 2000
    ..melanogaster four circadian clock proteins termed PERIOD (PER), TIMELESS (TIM), dCLOCK (dCLK), and CYCLE (CYC/dBMAL1) function in a transcriptional feedback loop that is a core element of the oscillator mechanism...
  46. ncbi Modeling the molecular regulatory mechanism of circadian rhythms in Drosophila
    J C Leloup
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium
    Bioessays 22:84-93. 2000
    ..Finally, the model shows that to produce a robust rhythm the various clock genes must be expressed at the appropriate levels since sustained oscillations only occur in a precise range of parameter values. BioEssays 22:84-93, 2000...
  47. ncbi Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity
    Eun Young Kim
    Department of Molecular Biology and Biochemistry, Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ 08854, USA
    Neuron 34:69-81. 2002
    ..Our findings suggest that, in addition to a role in generating circadian rhythms, dCLK modulates the direct effects of light on locomotion...
  48. ncbi Perspectives: neurobiology. The CRYs fo flies and mice
    P E Hardin
    Department of Biology, University of Houston, Houston, TX 77204, USA
    Science 286:2460-1. 1999
  49. ncbi Cycling vrille expression is required for a functional Drosophila clock
    J Blau
    Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA
    Cell 99:661-71. 1999
    ..Cycling is directly regulated by the transcription factors dCLOCK and CYCLE, which are also required for oscillations of period and timeless RNA...
  50. ncbi Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm
    H R Ueda
    ERATO Kitano Symbiotic Systems Group, Suite 6A, M31, 6 31 15 Jinguumae, Shibuya, Tokyo, 150 0001, Japan
    J Theor Biol 210:401-6. 2001
    ..Moreover, the interlocked feedback model has robust properties in oscillations...
  51. ncbi The ins and outs of circadian timekeeping
    S A Brown
    Départment de Biologie Moleculaire Université de Genéve Sciences II 30 quai Ernest Ansermet, 1211, Geneve 4, Switzerland steven
    Curr Opin Genet Dev 9:588-94. 1999
    ..Taken together, these observations are reshaping thinking about inputs and outputs of metazoan circadian clocks...
  52. ncbi Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock
    B Kloss
    Laboratory of Genetics and, National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 30:699-706. 2001
    ..The varying associations of PER, DBT and TIM appear to determine the onset and duration of nuclear PER function within the Drosophila clock...
  53. pmc PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription
    C Lee
    Graduate Program in Microbiology and Molecular Genetics, Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 19:5316-25. 1999
    The Drosophila CLOCK (dCLOCK) and CYCLE (CYC) (also referred to as dBMAL1) proteins are members of the basic helix-loop-helix PAS (PER-ARNT-SIM) superfamily of transcription factors and are required for high-level expression of the ..
  54. ncbi Chaos and birhythmicity in a model for circadian oscillations of the PER and TIM proteins in drosophila
    - Leloup
    Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    J Theor Biol 198:445-59. 1999
    ..e. the coexistence between two stable regimes of limit cycle oscillations...
  55. ncbi Molecular bases for circadian clocks
    J C Dunlap
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Cell 96:271-90. 1999
  56. ncbi CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity
    P Emery
    Department of Biology, Brandeis University Waltham, Massachusetts 02454, USA
    Cell 95:669-79. 1998
    ..transcription is under circadian regulation, influenced by the Drosophila clock genes period, timeless, Clock, and cycle. We also show that cry protein levels are dramatically affected by light exposure...
  57. ncbi CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless
    J E Rutila
    NSF, Center for Biological Timing, and Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Cell 93:805-14. 1998
    ..indicates that it also encodes a bHLH-PAS transcription factor and is a Drosophila homolog of the human protein BMAL1. cyc is a nonsense mutation, consistent with its strong loss-of-function phenotype...
  58. ncbi Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila
    Wen Feng Chen
    Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854, USA
    J Biol Rhythms 21:256-71. 2006
    ..increases in the levels of tim RNA are abolished or greatly reduced in the absence of functional CLOCK (CLK) or CYCLE (CYC) but not PER or TIM...
  59. ncbi Light-dependent sequestration of TIMELESS by CRYPTOCHROME
    M F Ceriani
    Department of Cell Biology and NSF Center for Biological Timing, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 285:553-6. 1999
    ..Thus, CRY acts as a circadian photoreceptor by directly interacting with core components of the circadian clock...
  60. ncbi Central and peripheral circadian oscillator mechanisms in flies and mammals
    Nicholas R J Glossop
    Department of Biology and Biochemistry, University of Houston, 369 Science and Research 2 Bldg, Houston, TX 77204 5001, USA
    J Cell Sci 115:3369-77. 2002
    ..The core feedback loop in peripheral oscillators might therefore be functionally well conserved, and central oscillators could be specialized versions of a basic oscillator design...
  61. ncbi Time flies for Drosophila
    A L Scully
    Department of Cell Biology and NSF Center for Biological Timing, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 100:297-300. 2000
  62. ncbi Circadian clocks in the mammalian brain
    M Hastings
    Department of Anatomy, University of Cambridge, Cambridge, UK
    Bioessays 22:23-31. 2000
    ..In Drosophila, the protein products of these genes interact in a negative feedback loop, establishing a circadian cycle in gene expression...
  63. pmc A role for microRNAs in the Drosophila circadian clock
    Sebastian Kadener
    National Center for Behavioral Genomics and Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Genes Dev 23:2179-91. 2009
    ..Moreover, clk transgenes harboring mutated bantam sites in their 3' UTRs rescue rhythms of clk mutant flies much less well than wild-type CLK transgenes...
  64. ncbi Egg-laying rhythm in Drosophila melanogaster
    Manjunatha T
    Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560 064, India
    J Genet 87:495-504. 2008
    ..In this review, we discuss our current understanding of the circadian egg-laying rhythm in D. melanogaster, and the possible molecular and physiological mechanisms that control the rhythmic output of the egg-laying process...
  65. pmc A male-specific fatty acid omega-hydroxylase, SXE1, is necessary for efficient male mating in Drosophila melanogaster
    Shinsuke Fujii
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 180:179-90. 2008
    ..transcriptional regulator DSX(M) and the clock genes are necessary for cycling of sxe1 mRNA during the diurnal cycle. Similar to sxe1 mRNA, expression of SXE1 protein oscillates in a diurnal fashion, with highest protein levels ..
  66. pmc Activating PER repressor through a DBT-directed phosphorylation switch
    Saul Kivimäe
    Laboratory of Genetics, The Rockefeller University, New York, New York, USA
    PLoS Biol 6:e183. 2008
    ....
  67. pmc The blue-light photoreceptor CRYPTOCHROME is expressed in a subset of circadian oscillator neurons in the Drosophila CNS
    Juliana Benito
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5001, USA
    J Biol Rhythms 23:296-307. 2008
    ..nucleus and the cytoplasm of these neurons, and its subcellular localization does not change over the circadian cycle. Although CRY is absent in DN2s and DN3s, cry promoter activity and/or cry mRNA accumulation can be detected in ..
  68. ncbi Eukaryotic circadian systems: cycles in common
    J C Dunlap
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Genes Cells 4:1-10. 1999
    ..Post-transcriptional control governs the amount and type of FRQ and makes the clock responsive to temperature...
  69. pmc Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis
    R Ratan
    Biology Department, Trinity College, Hartford, Connecticut 06106, USA
    Genetics 178:839-50. 2008
    ..These results provide a framework for studies of the more complex mammalian importin alpha-gene family...
  70. pmc Mathematical identification of critical reactions in the interlocked feedback model
    Hiroyuki Kurata
    Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Fukuoka, Japan
    PLoS ONE 2:e1103. 2007
    ..Use of MAR clearly identified the critical reactions responsible for determining the circadian cycle in the Drosophila interlocked circadian clock model...
  71. pmc TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock
    V Suri
    Department of Biochemistry, Howard Hughes Medical Institute, 415 South Street, Brandeis University, Waltham, MA 02454, USA
    EMBO J 18:675-86. 1999
    ..When heat shocked, TIM levels in these flies rapidly increased and initiated a molecular cycle of PER accumulation and processing with dynamics very similar to the PER cycle observed in wild-type flies...
  72. ncbi Perchance to dream: solving the mystery of sleep through genetic analysis
    Paul J Shaw
    The Neurosciences Institute, 10640 John J Hopkins Dr, San Diego, California 92121, USA
    J Neurobiol 54:179-202. 2003
    ..In this article we will review recent studies that have used genetic techniques to evaluate sleep in the fruit fly and the mouse...
  73. ncbi Requirement of circadian genes for cocaine sensitization in Drosophila
    R Andretic
    Department of Biology, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Science 285:1066-8. 1999
    ..and animal models and associated with enhanced drug craving, is eliminated in flies mutant for period, clock, cycle, and doubletime, but not in flies lacking the gene timeless...
  74. ncbi Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion
    Adrian Rothenfluh
    Department of Anatomy, University of California at San Francisco, 513 Parnassus Avenue, 94143 0452, USA
    Curr Opin Neurobiol 12:639-45. 2002
    ..Surprising similarities between flies and mammals have begun to emerge at the behavioral, neurochemical and molecular levels...
  75. ncbi Cocaine addiction: clues from Drosophila on drugs
    M E Wolf
    Department of Neuroscience, The Chicago Medical School, 3333 Green Bay Road, North Chicago, Illinois, 60064 3095, USA
    Curr Biol 9:R770-2. 1999
    ....
  76. pmc Animal cryptochromes mediate magnetoreception by an unconventional photochemical mechanism
    Robert J Gegear
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 463:804-7. 2010
    ..This work emphasizes the utility of Drosophila transgenesis for elucidating the precise mechanisms of Cry-mediated magnetosensitivity in insects and also in vertebrates such as migrating birds...
  77. ncbi Neural substrates of Drosophila rhythms revealed by mutants and molecular manipulations
    M Kaneko
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Curr Opin Neurobiol 8:652-8. 1998
    ..Similar studies in other insect species have suggested considerable diversity in the anatomical and neurochemical properties of pacemaker cells, as well as in the mechanisms of clock-gene regulation...
  78. ncbi A clockwork explosion!
    S M Reppert
    Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 21:1-4. 1998
  79. ncbi Circadian pacemaker neurons transmit and modulate visual information to control a rapid behavioral response
    Esteban O Mazzoni
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Neuron 45:293-300. 2005
    ..Furthermore, as clock gene mutations also affect photophobicity, the pacemaker neurons modulate the sensitivity of larvae to light, generating a circadian rhythm in visual sensitivity...
  80. ncbi Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD
    Ozkan Yildiz
    Department of Structural Biology, Max Planck Institute for Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Mol Cell 17:69-82. 2005
    ..We show that alphaF is essential for dPER homodimerization and that the PAS-A-alphaF interaction plays a crucial role in dPER clock function, as it is affected by the 29 hr long-period perL mutation...
  81. ncbi Circadian rhythms. New cogwheels in the clockworks
    U Schibler
    Nature 393:620-1. 1998
  82. ncbi Circadian clocks and natural antisense RNA
    Susan K Crosthwaite
    School of Biological Sciences, Smith Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    FEBS Lett 567:49-54. 2004
    ....
  83. ncbi Clock mechanisms in Drosophila
    Ralf Stanewsky
    Universitat Regensburg, Institut fur Zoologie, Lehrstuhl für Entwicklungsbiologie, Universitatsstrasse 31, 93040 Regensburg, Germany
    Cell Tissue Res 309:11-26. 2002
    ..Two interlocked transcriptional feedback loops involving at least the period, timeless, Clock,and cycle genes generate molecular oscillations that are believed to control behavioral rhythmicity and other clock outputs...
  84. ncbi Functional and evolutionary implications of natural variation in clock genes
    R Costa
    Dipartimento di Biologia, Universita di Padova, Italy
    Curr Opin Neurobiol 8:659-64. 1998
    ..Interspecific analysis of per expression patterns reveals evolutionary alterations in this clock gene's regulation...
  85. ncbi Activating inhibitors and inhibiting activators: a day in the life of a fly
    P E Hardin
    Department of Biology and Biochemistry, University of Houston, Texas 77204 5513, USA
    Curr Opin Neurobiol 8:642-7. 1998
    ..These studies, along with those in other organisms, suggest that circadian feedback loops are widespread and that genes within these feedback loops are conserved between Drosophila and mammals...
  86. ncbi Time marches on
    C B Green
    Dept of Biology, NSF Center for Biological Timing, University of Virginia, Charlottesville 22903, USA
    Trends Cell Biol 8:342-3. 1998
  87. doi Cytoplasmic interaction with CYCLE promotes the post-translational processing of the circadian CLOCK protein
    Christian Maurer
    Biochemistry Center Heidelberg, University of Heidelberg, Im Neuenheimer Feld 328, Heidelberg, Germany
    FEBS Lett 583:1561-6. 2009
    ..The contribution of the hetero-dimerization partner CYCLE (CYC) to the post-translational regulation of CLK is largely unknown...
  88. pmc Peripheral clocks and their role in circadian timing: insights from insects
    J M Giebultowicz
    Department of Entomology, Oregon State University, Corvallis, OR 97331 29 07, USA
    Philos Trans R Soc Lond B Biol Sci 356:1791-9. 2001
    ..Circadian systems in complex animals may include many peripheral clocks with tissue-specific functions and a varying degree of autonomy, which seems to be correlated with their sensitivity to external entraining signals...
  89. ncbi Intercellular coupling mechanism for synchronized and noise-resistant circadian oscillators
    Hiroki R Ueda
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113, Japan
    J Theor Biol 216:501-12. 2002
    ....
  90. ncbi Circadian rhythm biochemistry: from protein degradation to sleep and mating
    N Ishida
    Clock Cell Biology, National Institute of Advanced Industrial Science and Technology AIST, IMCB 6 5, 1 1 1 Higashi, Tsukuba 305 8566, Japan
    Biochem Biophys Res Commun 286:1-5. 2001
  91. ncbi Circadian rhythms: mop up the clock!
    S A Brown
    Departement de Biologie Moleculaire, Sciences II, Université de Genève 30, Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Curr Biol 11:R268-70. 2001
    ..Similarities and differences have been identified between insect and mammalian oscillators. Recent studies have shed new light on two mammalian clock components: Mop3 and Per2.
  92. ncbi Circadian regulation of gene expression in animals
    J A Ripperger
    Departement de Biologie Moleculaire, Science II, Universite de Geneve, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Curr Opin Cell Biol 13:357-62. 2001
    ..In mammals, a master pacemaker localized in the suprachiasmatic nucleus synchronizes peripheral clocks via humoral cues. However, restricted feeding can uncouple peripheral oscillators from the suprachiasmatic pacemaker...
  93. ncbi Regulation of the cycling of timeless (tim) RNA
    G K Wang
    Department of Neuroscience and Center for Sleep and Respiratory Neurobiology, Howard Hughes Medical Institute, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    J Neurobiol 47:161-75. 2001
    ..activation of both genes requires the basic helix-loop-helix (bHLH) PAS transcription factors dCLOCK (dCLK) and CYCLE (CYC), which bind E-box elements...
  94. ncbi Invited review: Sleeping flies don't lie: the use of Drosophila melanogaster to study sleep and circadian rhythms
    Joan C Hendricks
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Appl Physiol (1985) 94:1660-72; discussion 1673. 2003
    ..Nonetheless, studies have already established that two transcription factors alter rest and rest homeostasis. The implications of these advances for the future of sleep research are summarized...
  95. ncbi A brief history of circadian time
    A S Loudon
    School of Biological Sciences, University of Manchester, Oxford Road, M13 9PT, Manchester, UK
    Trends Genet 16:477-81. 2000
    ..We now know that tau is the mammalian homologue of a Drosophila circadian clock component (double-time) that plays an important role in regulating clock protein turnover...
  96. ncbi Cryptochromes: sensory reception, transduction, and clock functions subserving circadian systems
    J C Hall
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Curr Opin Neurobiol 10:456-66. 2000
    ..In the latter tissue, the hypothalamic suprachiasmatic nucleus, mouse CRYs are closely connected to the multimolecule murine clock mechanism...
  97. ncbi Serotonin modulates circadian entrainment in Drosophila
    Quan Yuan
    Howard Hughes Medical Institute, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Neuron 47:115-27. 2005
    ..These data identify a molecular connection between serotonin signaling and the central clock component TIM and suggest a homeostatic mechanism for the regulation of circadian photosensitivity in Drosophila...
  98. pmc takeout, a novel Drosophila gene under circadian clock transcriptional regulation
    W V So
    Howard Hughes Medical Institute, NSF Center for Biological Timing, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Mol Cell Biol 20:6935-44. 2000
    ..The circadian delayed transcriptional phase is therefore most likely the result of indirect regulation through unknown transcription factors...
  99. pmc A clock gene, period, plays a key role in long-term memory formation in Drosophila
    Takaomi Sakai
    Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi 371 8511, Japan
    Proc Natl Acad Sci U S A 101:16058-63. 2004
    ..In contrast, mutations in other clock genes (timeless, dClock, and cycle) did not affect LTM formation...
  100. ncbi Circadian rhythms. Marking time for a kingdom
    M W Young
    Laboratory of Genetics and National Science Foundation Center for Biological Timing, The Rockefeller University, New York, NY 10021
    Science 288:451-3. 2000

Research Grants10

  1. IDENTIFICATION AND ANALYSIS OF CLOCK CONTROLLED GENES
    Jennifer Loros; Fiscal Year: 2007
    ..In Specific Aim 1 we will follow up the finding in Neurospora that a critical cell cycle regulator is clock-controlled and is essential for an output oscillator coupled to the clock loop...
  2. GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCK
    Jay Dunlap; Fiscal Year: 2007
    ..through synthesis and through modification, factor important in determining[unreadable] the kinetics of the clock cycle. In Specific Aim 2 we will study what[unreadable] regulates FRQ translation and how this responds to external ..
  3. PREPHASE I GENE/IMMUNE THERAPY OF MALIGNANT BRAIN TUMOR
    HASSAN FATHALLAH SHAYKH; Fiscal Year: 2001
    ..abstract_text> ..
  4. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
    ..The health relatedness of these studies is that an understanding of circuits underlying sensory perception is relevant for brain disorders with a neurological or psychiatric basis. ..
  5. Characterization of Sleep Mutants of Drososphila
    Chiara Cirelli; Fiscal Year: 2009
    ..This research will help to identify the molecular mechanisms regulating the need for sleep and provide novel clues to its functions. ..
  6. Formation of an Olfactory Sensory Map
    LESLIE VOSSHALL; Fiscal Year: 2006
    ..The health relatedness of these studies is that cellular and molecular factors that regulate axonal pathfinding may have direct application to neurological and psychiatric disorders with a developmental basis. ..
  7. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
    ..melanogaster ..
  8. Molecular Biology of the Odorant Receptors
    Leslie B Vosshall; Fiscal Year: 2011
    ..The Health-Relatedness of this proposal is that such chemical agents may act to reduce infectious disease transmission by vector insects in the future. ..
  9. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
    ..of chronobiology in this model system may provide insights into the nature of certain rhythm-related disorders of humans, some of which are associated with genetic variations of Drosophila clock gene orthologs [unreadable] [unreadable]..
  10. A transgenic model of ocular inflammation
    Russell Van Gelder; Fiscal Year: 2007
    ..unreadable] [unreadable]..