crq

Summary

Gene Symbol: crq
Description: croquemort
Alias: CD36, CG31655, CG4280, CRQ, Cd36, Cqr, Crq, D-CD36, Dmel\CG4280, anon-WO0140519.8, cqm, cqr, CG4280 gene product from transcript CG4280-RE, CD36-like, CG4280-PA, CG4280-PB, CG4280-PC, CG4280-PD, CG4280-PE, crq-PA, crq-PB, crq-PC, crq-PD, crq-PE
Species: fruit fly

Top Publications

  1. pmc Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster
    Will Wood
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    J Cell Biol 173:405-16. 2006
  2. pmc Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis
    Lucas Waltzer
    Centre de Biologie du Développement CNRS, 31062 Toulouse, France
    EMBO J 21:5477-86. 2002
  3. ncbi Caspases function in autophagic programmed cell death in Drosophila
    Damali N Martin
    Center for Biosystems Research, University of Maryland Biotechnology Institute, and Department of Cell Biology, University of Maryland, College Park, Maryland 20742, USA
    Development 131:275-84. 2004
  4. ncbi gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila
    Teresa B Alfonso
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 248:369-83. 2002
  5. ncbi The PDGF/VEGF receptor controls blood cell survival in Drosophila
    Katja Brückner
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Dev Cell 7:73-84. 2004
  6. ncbi Developmental control of blood cell migration by the Drosophila VEGF pathway
    Nam K Cho
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
    Cell 108:865-76. 2002
  7. pmc Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Biol 168:567-73. 2005
  8. ncbi Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity
    Birgitta Olofsson
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Dev Biol 279:233-43. 2005
  9. pmc Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
    Lynda M Stuart
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 170:477-85. 2005
  10. ncbi Steroid regulation of autophagic programmed cell death during development
    C Y Lee
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Development 128:1443-55. 2001

Research Grants

Scientific Experts

  • Richard G Vogt
  • Christian Schlotterer
  • Katja Brückner
  • Marie Meister
  • M S Inamdar
  • CARL THUMMEL
  • Marc Haenlin
  • Ana Talamillo
  • E H Baehrecke
  • Nathalie C Franc
  • D Schneider
  • C R Dearolf
  • Katie J Woodcock
  • Lucas Waltzer
  • Will Wood
  • Yoshinobu Nakanishi
  • Akiko Shiratsuchi
  • Saikat Ghosh
  • Takayuki Kuraishi
  • Shanming Ji
  • Cheng Yu Lee
  • Johanna Ulvila
  • Christine Kocks
  • Marc S Dionne
  • Saori Nonaka
  • Junko Manaka
  • Lynda M Stuart
  • Jeroen Poels
  • J Poels
  • Christina O Igboin
  • Leire Herboso
  • Rebecca I Clark
  • C Y Lee
  • Viktor Honti
  • Stephanie Bunt
  • Martin Stofanko
  • Magdalena M Baer
  • Christina K McPhee
  • Isabella Vlisidou
  • Dani Osman
  • Alice K H Shia
  • Bernard Charroux
  • Leigh Cuttell
  • Zachary Nichols
  • Estee Kurant
  • Yuh Ru Lin
  • Kartik Venkatachalam
  • Jean Marc Reichhart
  • Wei Li
  • Richard Benton
  • Carolyn Pirraglia
  • Archana Nelliot
  • Haruhiro Higashida
  • Mika Ramet
  • Antonio Jacinto
  • R Alan B Ezekowitz
  • Colin J Davidson
  • Brian Stramer
  • Birgitta Olofsson
  • Tomas Dolezal
  • Damali N Martin
  • Magda Paladi
  • Heather C Sears
  • Cory J Evans
  • Sudip Mandal
  • Lolitika Mandal
  • Fr d ric Geissmann
  • Katrin Kierdorf
  • Laetitia Bataillé
  • Arashdeep Singh
  • Clara A Pouchelon
  • Val rie Vivancos
  • Xiudeng Zheng
  • Ming Sun
  • Lin Li
  • Qinmiao Sun
  • Teresa B Alfonso
  • M D Lavine
  • Nam K Cho
  • Dahua Chen
  • Liwei Sun
  • U Theopold
  • Kaz Nagaosa
  • Toshinobu Mori
  • T O Tingvall
  • Milos R Spasic
  • M R Spasić
  • J Mutert
  • K K Norga
  • P Callaerts

Detail Information

Publications73

  1. pmc Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster
    Will Wood
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    J Cell Biol 173:405-16. 2006
    ....
  2. pmc Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis
    Lucas Waltzer
    Centre de Biologie du Développement CNRS, 31062 Toulouse, France
    EMBO J 21:5477-86. 2002
    ..Our results suggest that the inclusion or exclusion of the N-finger in the naturally occurring isoforms of Srp can provide an effective means of extending the versatility of srp function during development...
  3. ncbi Caspases function in autophagic programmed cell death in Drosophila
    Damali N Martin
    Center for Biosystems Research, University of Maryland Biotechnology Institute, and Department of Cell Biology, University of Maryland, College Park, Maryland 20742, USA
    Development 131:275-84. 2004
    ..These studies suggest that aspects of the cytoskeleton may be required for changes in dying salivary glands. Furthermore, caspases are not only used during apoptosis, but also function in the regulation of autophagic cell death...
  4. ncbi gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila
    Teresa B Alfonso
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 248:369-83. 2002
    ..Our results suggest that both gcm and gcm2 are required together for the proliferation of plasmatocyte precursors, the expression of Croquemort protein, and the ability of plasmatocytes to convert into macrophages...
  5. ncbi The PDGF/VEGF receptor controls blood cell survival in Drosophila
    Katja Brückner
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Dev Cell 7:73-84. 2004
    ..This function of PVR shows striking conservation with mammalian hematopoiesis and establishes Drosophila as a model to study hematopoietic cell survival in development and disease...
  6. ncbi Developmental control of blood cell migration by the Drosophila VEGF pathway
    Nam K Cho
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University, Stanford, CA 94305, USA
    Cell 108:865-76. 2002
    ..The results suggest that the Drosophila VEGF pathway guides developmental migrations of blood cells, and we speculate that the ancestral function of VEGF pathways was to guide blood cell movement...
  7. pmc Live imaging of wound inflammation in Drosophila embryos reveals key roles for small GTPases during in vivo cell migration
    Brian Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Biol 168:567-73. 2005
    ..Cdc42 is necessary for maintaining cellular polarity and yet, despite in vitro evidence, is dispensable for sensing and crawling toward wound cues...
  8. ncbi Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity
    Birgitta Olofsson
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Dev Biol 279:233-43. 2005
    ....
  9. pmc Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
    Lynda M Stuart
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, MA 02114, USA
    J Cell Biol 170:477-85. 2005
    ..scavenger receptor Croquemort as a receptor for Staphylococcus aureus, implicating for the first time the CD36 family as phagocytic receptors for bacteria...
  10. ncbi Steroid regulation of autophagic programmed cell death during development
    C Y Lee
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Development 128:1443-55. 2001
    ..In contrast, E93 expression is sufficient to induce the removal of cells by phagocytes in the absence of the H99 genes. These studies indicate that apoptosis and autophagy utilize some common regulatory mechanisms...
  11. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
    ..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo...
  12. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
    The CD36 family of transmembrane receptors is present across metazoans and has been implicated biochemically in lipid binding and transport...
  13. doi The SNMP/CD36 gene family in Diptera, Hymenoptera and Coleoptera: Drosophila melanogaster, D. pseudoobscura, Anopheles gambiae, Aedes aegypti, Apis mellifera, and Tribolium castaneum
    Zachary Nichols
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Insect Biochem Mol Biol 38:398-415. 2008
    ..thought to play a role in odor detection; SNMPs belong to a larger gene family characterized by the human protein CD36. We have identified 12-14 candidate SNMP/CD36 homologs from each of the genomes of Drosophila melanogaster, D...
  14. ncbi Specification of Drosophila hematopoietic lineage by conserved transcription factors
    T Lebestky
    Molecular Biology Institute, Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Science 288:146-9. 2000
    ..Given the similarities of Srp and Lz to mammalian GATA and AML1 proteins, observations in Drosophila are likely to have broad implications for understanding mammalian hematopoiesis and leukemias...
  15. ncbi Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila
    N C Franc
    Cutaneous Biology Research Center, Laboratory of Developmental Immunology, and Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School Charlestown, MA 02129, USA
    Science 284:1991-4. 1999
    ..Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages...
  16. doi Cell lineage tracing reveals the plasticity of the hemocyte lineages and of the hematopoietic compartments in Drosophila melanogaster
    Viktor Honti
    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Temesvari krt 62, 6726 Szeged, Csongrad, Hungary
    Mol Immunol 47:1997-2004. 2010
    ..This system allowed us to distinguish two major embryonic hemocyte lineages, the crq and Dot lineages, in two, physically separated compartments, the embryonic macrophages and the embryonic lymph ..
  17. doi Expression of the Scavenger Receptor Class B type I (SR-BI) family in Drosophila melanogaster
    Leire Herboso
    CIC bioGUNE, Bizkaia Technology Park, Derio, Spain
    Int J Dev Biol 55:603-11. 2011
    ..The Scavenger Receptors Class B Type I (SR-BI) are membrane proteins that belong to the CD36 family and participate in the selective uptake of high density lipoprotein cholesteryl ester in the mammalian ..
  18. ncbi Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells
    N C Franc
    Division of Hematology, Children s Hospital, Boston, Massachusetts 02115, USA
    Immunity 4:431-43. 1996
    ..This receptor, croquemort (catcher of death), is a member of the CD36 superfamily...
  19. pmc Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons
    Estee Kurant
    Laboratory of Developmental Neurogenetics, Rockefeller University, 1230 York Avenue, New York, NY 10065 6399, USA
    Cell 133:498-509. 2008
    ..Our study introduces an important factor in tissue-resident apoptotic clearance and underscores the prominent role of glia as "semiprofessional" phagocytes in the nervous system...
  20. ncbi Function of Rho GTPases in embryonic blood cell migration in Drosophila
    Magda Paladi
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
    J Cell Sci 117:6313-26. 2004
    ..We find eight deletions that cause defects in macrophage migration suggesting the existence of approximately ten zygotic genes essential for macrophage migration...
  21. ncbi Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis
    Heather C Sears
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue 68 230B, Cambridge, MA 02139, USA
    Development 130:3557-65. 2003
    ..These data indicate that macrophage-mediated clearance of cell corpses is required for proper morphogenesis of the Drosophila CNS...
  22. ncbi Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila
    Takayuki Kuraishi
    Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
    Exp Cell Res 313:500-10. 2007
    ..These results collectively indicate that calreticulin is the first molecule to be identified as a marker for phagocytosis of apoptotic cells by Drosophila phagocytes...
  23. pmc Active hematopoietic hubs in Drosophila adults generate hemocytes and contribute to immune response
    Saikat Ghosh
    Developmental Genetics Laboratory, Department of Biological Sciences, Indian Institute of Science Education and Research IISER Mohali, Knowledge City, Sector 81, Manauli P O 140306, India
    Dev Cell 33:478-88. 2015
    ..The presence of progenitors and differentiated hemocytes embedded in a functional network of Laminin A and Pericardin within this hematopoietic hub projects it as a simple version of the vertebrate bone marrow. ..
  24. pmc Integrin αPS3/βν-mediated phagocytosis of apoptotic cells and bacteria in Drosophila
    Saori Nonaka
    Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
    J Biol Chem 288:10374-80. 2013
    ..These results collectively indicated that integrin αPS3/βν serves as a receptor in the phagocytosis of apoptotic cells and bacteria by Drosophila phagocytes...
  25. pmc Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila
    Shanming Ji
    1 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 2 State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 3
    Nat Commun 5:3458. 2014
    ..Collectively, our study uncovers a mechanism by which a feedback regulatory loop involving MyD88 and Pellino controls Toll-mediated signalling, thereby maintaining homeostasis of host innate immunity. ..
  26. pmc Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet
    Katie J Woodcock
    Immunity 42:133-44. 2015
    ..Drosophila macrophages produced the JAK-STAT-activating cytokine upd3, in a scavenger-receptor (crq) and JNK-dependent manner...
  27. pmc Requirement for a core 1 galactosyltransferase in the Drosophila nervous system
    Yuh Ru Lin
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Dev Dyn 237:3703-14. 2008
    ..Lectin staining and blotting experiments confirmed that C1GalTA contributes to the synthesis of Gal-beta1,3-GalNAc in vivo. Our results identify a role for mucin-type O-glycosylation during neural development in Drosophila...
  28. pmc Multiple TGF-β superfamily signals modulate the adult Drosophila immune response
    Rebecca I Clark
    Centre for the Molecular and Cellular Biology of Inflammation and Peter Gorer Department of Immunobiology, King s College London School of Medicine, London SE1 1UL, UK
    Curr Biol 21:1672-7. 2011
    ..Together, these data imply a model in which the bone morphogenetic protein (BMP) dpp is an important inhibitor of inflammation following sterile injury whereas the activin-like dawdle determines the nature of the induced immune response...
  29. doi The insect SNMP gene family
    Richard G Vogt
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Insect Biochem Mol Biol 39:448-56. 2009
    ..SNMPs are one of three insect gene clades related to the human fatty acid transporter CD36. We previously characterized the CD36 gene family in 4 insect Orders that effectively cover the Holometabola, or ..
  30. pmc Porphyromonas gingivalis-host interactions in a Drosophila melanogaster model
    Christina O Igboin
    Section of Oral Biology, College of Dentistry, The Ohio State University, 3185 Postle Hall, 305 W Twelfth Avenue, Columbus, OH 43210, USA
    Infect Immun 79:449-58. 2011
    ..This study demonstrates that the Drosophila killing model is a useful high-throughput model for characterizing the host response to P. gingivalis infection and uncovering novel interactions between the bacterium and the host...
  31. pmc Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila
    Stephanie Bunt
    Department of Zoology, University of Cambridge, UK
    Dev Cell 19:296-306. 2010
    ..Such regulated interplay between cell-cell and cell-matrix interactions is likely to have wide relevance in organogenesis and congenital disease...
  32. ncbi Glia maintain follower neuron survival during Drosophila CNS development
    G E Booth
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, Cambridge, UK
    Development 127:237-44. 2000
    ..This differential requirement of neurons for glia is instructive in patterning and links control of cell number with axon guidance during CNS development...
  33. pmc An appetite for destruction: from self-eating to cell cannibalism as a neuronal survival strategy
    Jeroen Poels
    Laboratory of Behavioral and Developmental Genetics, KU Leuven, Leuven, Belgium
    Autophagy 8:1401-3. 2012
    ..Finally, we uncovered a new survival mechanism in AMPK-deficient neurons--cell cannibalism...
  34. pmc Autophagy and phagocytosis-like cell cannibalism exert opposing effects on cellular survival during metabolic stress
    J Poels
    Laboratory of Behavioral and Developmental Genetics, Leuven, Belgium
    Cell Death Differ 19:1590-601. 2012
    ..We provide new insights into the roles of autophagy and phagocytosis in the neuronal metabolic stress response and open new avenues into understanding of human disease and development of therapeutic strategies...
  35. pmc Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity
    Martin Stofanko
    Institute of Biomedical Research, University of Birmingham, Edgbaston, England
    PLoS ONE 5:e14051. 2010
    ..Taken together, our data suggest that lamellocytes arise from plasmatocytes and that plasmatocytes may be inherently plastic, possessing the ability to differentiate further into lamellocytes upon appropriate challenge...
  36. pmc Activation of autophagy during cell death requires the engulfment receptor Draper
    Christina K McPhee
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 465:1093-6. 2010
    ..Further, Drpr is the first factor that distinguishes autophagy that is associated with cell death from autophagy associated with cell survival...
  37. doi Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis
    Leigh Cuttell
    Medical Research Council Cell Biology Unit, MRC Laboratory for Molecular Cell Biology and Cell and Developmental Biology Department, University College London, Gower Street, London WC1E 6BT, UK
    Cell 135:524-34. 2008
    ..Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway...
  38. pmc Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells
    Kartik Venkatachalam
    Departments of Biological Chemistry and Neuroscience, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 135:838-51. 2008
    ..Since hematopoietic cells in humans are involved in clearance of apoptotic cells, our results raise the possibility that bone marrow transplantation may limit the progression of MLIV...
  39. pmc Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response
    Bernard Charroux
    Institut de Biologie du Developpement de Marseille Luminy, Unite Mixte de Recherche 6216, Centre National de la Recherche Scientifique, Université de la Méditerrannée Aix Marseille II, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 106:9797-802. 2009
    ..Finally, we show that plasmatocytes are involved in immune surveillance during pupal development, because they prevent bacterial infection that causes pupal lethality...
  40. pmc A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO
    Dani Osman
    Unite Mixte de Recherche 5547, Centre National de Recherche Scientifique, Centre de Biologie du Developpement, Universite de Toulouse, Bat4R3, 1118 route de Narbonne, 31062 Toulouse, France
    Proc Natl Acad Sci U S A 106:12043-8. 2009
    ..Therefore Drosophila provides a promising genetically tractable model to investigate the conserved basis of leukemogenesis and to open avenues in AML therapy...
  41. pmc Drosophila embryos as model systems for monitoring bacterial infection in real time
    Isabella Vlisidou
    Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
    PLoS Pathog 5:e1000518. 2009
    ..Together these data show how Drosophila embryos can be used to track bacterial infection in real time and how mutant analysis can be used to genetically dissect the effects of specific bacterial virulence factors...
  42. pmc Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes
    Alice K H Shia
    Department of Biochemistry, University of Oxford, Oxford, UK
    J Cell Sci 122:4505-15. 2009
    ..These results show that in larvae, integration of the two responses in a systemic reaction depend on the production of a cytokine (spz), a process that strongly parallels the mammalian immune response...
  43. doi The role of apoptosis in shaping the tracheal system in the Drosophila embryo
    Magdalena M Baer
    Institute of Genetics, University of Cologne, Cologne, Germany
    Mech Dev 127:28-35. 2010
    ..Extruded cells die and are engulfed by macrophages. Our results suggest that the pattern of cell extrusion and death is not hard-wired, but is determined by environmental cues...
  44. ncbi In vitro evolution of preferred topoisomerase II DNA cleavage sites
    D A Burden
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 274:5227-35. 1999
    ..melanogaster, implying that it may be a site for the physiological action of this enzyme...
  45. pmc Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap
    A Braun
    Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Genetics 147:623-34. 1997
    ..We anticipate that this mutation, which we named domino, will prove a useful tool in the analysis of the role of hemocytes during the various aspects of immune response and melanotic tumor formation...
  46. ncbi Genetic analysis of protein kinase B (AKT) in Drosophila
    B E Staveley
    Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada
    Curr Biol 8:599-602. 1998
    ..These data implicate Dakt1 as a cell survival gene in Drosophila, consistent with cell protection studies in mammals...
  47. ncbi Fruit fly "leukemia"
    C R Dearolf
    Department of Pediatrics, Massachusetts General Hospital, Boston 02114, USA
    Biochim Biophys Acta 1377:M13-23. 1998
  48. ncbi Treatment of l(2)mbn Drosophila tumorous blood cells with the steroid hormone ecdysone amplifies the inducibility of antimicrobial peptide gene expression
    J L Dimarcq
    UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Insect Biochem Mol Biol 27:877-86. 1997
    ..We also report that expression of several regulatory molecules thought to be involved in the immune response is up-regulated by ecdysone in l(2)mbn cells...
  49. ncbi glide/gcm is expressed and required in the scavenger cell lineage
    R Bernardoni
    Institut de Génétique et Biologie Moléculaire et Cellulaire, IGBMC CNRS ULP, BP 163 67404 Illkirch, C U de Strasbourg, France
    Dev Biol 191:118-30. 1997
    ..These data and our findings on the dual role of glide/gcm indicate that glial cells and hemocytes/macrophages are functionally and molecularly related...
  50. ncbi Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila
    Cheng Yu Lee
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, 20742, USA
    Dev Biol 252:138-48. 2002
    ..mutants indicate that these genes regulate stage-specific transcription of the rpr, hid, ark, dronc, and crq cell death genes...
  51. ncbi Steroid-triggered death by autophagy
    C S Thummel
    Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East Room 5100, University of Utah, UT 84112 5331, USA
    Bioessays 23:677-82. 2001
    ..This paper also shows that E93 can direct cell death independently from the known death-inducer genes, defining a novel death pathway in Drosophila...
  52. ncbi Drosophila asrij is expressed in pole cells, trachea and hemocytes
    Maneesha S Inamdar
    Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, 560 064, Bangalore, India
    Dev Genes Evol 213:134-7. 2003
    ..Expression in the blood-cell lineage precedes that of known hematopoietic transcription factors. These results suggest that Drosophila asrij functions in the hematopoietic lineage...
  53. ncbi Transcriptional regulation of hematopoiesis in Drosophila
    Cory J Evans
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Blood Cells Mol Dis 30:223-8. 2003
    ..Herein, we describe the Drosophila blood cell types, their physical origin, and the transcriptional regulators that govern this process...
  54. ncbi Steroid regulation of midgut cell death during Drosophila development
    Cheng Yu Lee
    Center for Biosystems Research, University of Maryland Biotechnology Institute, University of Maryland, College Park, Maryland 20742, USA
    Dev Biol 250:101-11. 2002
    ..Dying midguts express the rpr, hid, ark, dronc, and crq cell death genes, suggesting that the core cell death machinery is involved in larval midgut cell death...
  55. pmc Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis
    Lucas Waltzer
    Centre de Biologie du Developpement, CNRS UMR 5547, 118 route de Narbonne, 31062 Toulouse, France
    EMBO J 22:6516-25. 2003
    ..We propose that interaction and cooperation between GATA and RUNX factors may play an important role in regulating blood cell formation from Drosophila to mammals...
  56. ncbi Insect hemocytes and their role in immunity
    M D Lavine
    Department of Entomology, University of Georgia, Athens, GA 30602, USA
    Insect Biochem Mol Biol 32:1295-309. 2002
    ..Cross-talk between the immune and nervous system may also play a role in regulating inflammation-like responses in insects during infection...
  57. ncbi Blood cells of Drosophila: cell lineages and role in host defence
    Marie Meister
    Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg, France
    Curr Opin Immunol 16:10-5. 2004
    ..Crystal cells and lamellocytes have no clear mammalian homologues. Research into the molecular mechanisms that underlie the various immune functions of Drosophila blood cells, such as non-self recognition, is now taking wing...
  58. ncbi Phagocytosis of apoptotic cells in mammals, caenorhabditis elegans and Drosophila melanogaster: molecular mechanisms and physiological consequences
    Nathalie C Franc
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Front Biosci 7:d1298-313. 2002
    ..Drosophila melanogaster will become the model of choice in genetically dissecting the molecular mechanisms underlying phagocytosis of apoptotic cells by 'professional' phagocytes such as macrophages...
  59. ncbi Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages
    Junko Manaka
    Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 1192, Japan
    J Biol Chem 279:48466-76. 2004
    ..These results indicate that Drosophila hemocytes/macrophages execute Draper-mediated phagocytosis to eliminate apoptotic cells...
  60. pmc Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes
    Colin J Davidson
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 169:215-29. 2005
    ..Finally, these experiments demonstrate the utility of genetic complementation in Drosophila to explore the functional evolution of duplicated genes in vertebrates...
  61. ncbi Microsatellite analysis of Drosophila melanogaster populations along a microclimatic contrast at lower Nahel Oren canyon, Mount Carmel, Israel
    Christian Schlotterer
    Institut fur Tierzucht und Genetik, Vienna University of Veterinary Medicine, Josef Baumann Gasse 1, 1210 Vienna, Austria
    Mol Biol Evol 19:563-8. 2002
    ..melanogaster populations was low (F(ST) = 0.0012). Also a tree of individuals based on the proportion of shared alleles and a model-based clustering method provided no evidence for population substructuring...
  62. ncbi The coagulation of insect hemolymph
    U Theopold
    Department of Molecular Biology and Functional Genomics, Stockholm University, Sweden
    Cell Mol Life Sci 59:363-72. 2002
    ..Some striking similarities between blood clotting in vertebrates and the reaction of insect cells involved in hemolymph coagulation have implications for a phylogenetic comparison of hemostasis between divergent animal classes...
  63. ncbi The active role of corpse engulfment pathways during cell competition
    Wei Li
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Fly (Austin) 1:274-8. 2007
    ..We also speculate about how cell interactions at clone boundaries may initiate cell competition...
  64. pmc A role for adenosine deaminase in Drosophila larval development
    Tomas Dolezal
    Developmental Biology Center, University of California, Irvine, California, USA
    PLoS Biol 3:e201. 2005
    ..The existence of such an independent mechanism has also been suggested in mammals...
  65. pmc The GATA factor Serpent is required for the onset of the humoral immune response in Drosophila embryos
    T O Tingvall
    Department of Molecular Biology and Functional Genomics, Arrhenius Laboratories for Natural Sciences, Stockholm University, S 106 91 Stockholm, Sweden
    Proc Natl Acad Sci U S A 98:3884-8. 2001
    ..In addition, the present study shows that signal transduction pathways controlling innate and epithelial defense reactions can be dissected genetically in Drosophila embryos...
  66. ncbi Using Drosophila as a model insect
    D Schneider
    Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Genet 1:218-26. 2000
    ..Specifically, I discuss recent work on the use of Drosophila to study the transmission of disease by insect vectors and to investigate insecticide function and development...
  67. ncbi Rac function in epithelial tube morphogenesis
    Carolyn Pirraglia
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Biol 290:435-46. 2006
    ..Our results demonstrate that regulation of cadherin-based adherens junctions by Rac is critical for salivary gland morphogenesis and that this regulation occurs through dynamin-mediated endocytosis...
  68. ncbi Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells
    Johanna Ulvila
    Department of Pediatrics and Biocenter Oulu, University of Oulu, FIN 90014, Oulu, Finland
    J Biol Chem 281:14370-5. 2006
    ..Our data provide insight into the mechanism of dsRNA internalization by Drosophila cells. These results have implications for dsRNA delivery into mammalian cells...
  69. ncbi Steroid regulation of programmed cell death during Drosophila development
    E H Baehrecke
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland, MD 20742, USA
    Cell Death Differ 7:1057-62. 2000
    ..This article reviews the current knowledge of steroid signaling and the regulation of programmed cell death during development of Drosophila...
  70. ncbi Fat-body remodeling in Drosophila melanogaster
    Archana Nelliot
    Genesis 44:396-400. 2006
    ..melanogaster is a hemocyte independent process...
  71. ncbi E93 directs steroid-triggered programmed cell death in Drosophila
    C Y Lee
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
    Mol Cell 6:433-43. 2000
    ..Furthermore, expression of E93 is sufficient to induce programmed cell death. We propose that the steroid induction of E93 determines a programmed cell death response during development...
  72. ncbi Fork head prevents apoptosis and promotes cell shape change during formation of the Drosophila salivary glands
    M M Myat
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Development 127:4217-26. 2000
    ....
  73. ncbi Innate recognition systems in insect immunity and development: new approaches in Drosophila
    N C Franc
    Cutaneous Biology Research Center, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, 13th Street, Building 149, Charlestown, MA 02129, USA
    Microbes Infect 2:243-50. 2000
    ..How particles are recognized is not well understood. Studies in insects, and Drosophila in particular, argue that these are powerful model systems to dissect this process...

Research Grants2

  1. STEROID REGULATION OF PROGRAMMED CELL DEATH
    CARL THUMMEL; Fiscal Year: 2003
    ..In addition, this study will provide insight into the molecular mechanisms by which systemic hormonal signals are refined into stage- and tissue-specific biological responses during development. ..
  2. Mechanisms of Steroid-Triggered Programmed Cell Death
    CARL THUMMEL; Fiscal Year: 2009
    ..Finally, our studies provide a foundation for determining how steroids control cell death in humans, with implications for understanding and treating human disease. ..