Genomes and Genes
Gene Symbol: complexin
Alias: BcDNA:GH27718, BcDNA:HL04936, BcDNA:RH26459, BcDNA:RH31085, CG32490, CPX, Cpx, DmCpx, Dmel\CG32490, dmCplx, CG32490 gene product from transcript CG32490-RAB, CG32490-PA, CG32490-PAA, CG32490-PAB, CG32490-PC, CG32490-PE, CG32490-PG, CG32490-PH, CG32490-PI, CG32490-PJ, CG32490-PK, CG32490-PL, CG32490-PM, CG32490-PO, CG32490-PP, CG32490-PS, CG32490-PU, CG32490-PV, CG32490-PW, CG32490-PX, CG32490-PY, CG32490-PZ, cpx-PA, cpx-PAA, cpx-PAB, cpx-PC, cpx-PE, cpx-PG, cpx-PH, cpx-PI, cpx-PJ, cpx-PK, cpx-PL, cpx-PM, cpx-PO, cpx-PP, cpx-PS, cpx-PU, cpx-PV, cpx-PW, cpx-PX, cpx-PY, cpx-PZ
Species: fruit fly
- A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growthSarah Huntwork
The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Building 46, Room 3243, Cambridge, Massachusetts 02139, USA
Nat Neurosci 10:1235-7. 2007..Here we demonstrate that spontaneous release at synapses is regulated by complexin, a SNARE complex-binding protein...
- Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutantJanani Iyer
Department of Biology and Center for Molecular Investigation of Neurological Disorders, Penn State University, University Park, PA 16802, United States
Mol Cell Neurosci 56:244-54. 2013The COMPLEXIN (CPX) proteins play a critical role in synaptic vesicle fusion and neurotransmitter release...
- Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activityRamon A Jorquera
The Picower Institute for Learning and Memory, Departments of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 32:18234-45. 2012..of SNARE-binding proteins have evolved to regulate synaptic exocytosis, including Synaptotagmin (SYT) and Complexin (CPX)...
- Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic PlasticityRichard W Cho
Department of Biology and Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Electronic address
Neuron 88:749-61. 2015..Here we show that the SNARE fusion clamp Complexin undergoes activity-dependent phosphorylation that alters the basic properties of neurotransmission in Drosophila...
- Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal MicroautophagyValerie Uytterhoeven
KU Leuven, Center for Human Genetics, Leuven Institute for Neurodegenerative Disease LIND, Laboratory of Neuronal Communication, Herestraat 49, 3000 Leuven, Belgium VIB Center for the Biology of disease, Leuven Institute for Neurodegenerative Disease LIND, Laboratory of Neuronal Communication, Herestraat 49, 3000 Leuven, Belgium
Neuron 88:735-48. 2015....
- Dynamic response of RNA editing to temperature in DrosophilaLeila E Rieder
BMC Biol 13:1. 2015..Previous reports suggest that RNA editing is responsive to environmental inputs in the form of temperature alterations. However, the molecular determinants underlying temperature-dependent RNA editing responses are not well understood...
- Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap libraryNick Lowe
The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Development 141:3994-4005. 2014..Our resource substantially increases the number of available protein traps in Drosophila and identifies new markers for cellular organelles and structures. ..
- Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivoRichard W Cho
Departments of Biology and Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139
Proc Natl Acad Sci U S A 111:10317-22. 2014b>Complexin (Cpx) is a SNARE-binding protein that regulates neurotransmission by clamping spontaneous synaptic vesicle fusion in the absence of Ca(2+) influx while promoting evoked release in response to an action potential...
- Miniature neurotransmission regulates Drosophila synaptic structural maturationBen Jiwon Choi
Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Neuron 82:618-34. 2014..Our results establish that miniature neurotransmission, a universal but often-overlooked feature of synapses, has unique and essential functions in vivo...
- Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clampMaria Bykhovskaia
Neuroscience Department, Universidad Central del Caribe, Bayamon, Puerto Rico
Biophys J 105:679-90. 2013..A cytosolic protein, complexin (Cpx), binds to the SNARE bundle, and its accessory helix (AH) functions to clamp synaptic vesicle fusion...
- Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexinLauren K Buhl
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
Mol Cell Neurosci 52:161-72. 2013..Here, we demonstrate that the C-terminus of Drosophila complexin (DmCpx) regulates localization to synapses and that alternative splicing of the C-terminus can differentially ..
- Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter releaseRichard W Cho
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Cell Neurosci 45:389-97. 2010The SNARE-binding protein complexin (Cpx) has been demonstrated to regulate synaptic vesicle fusion...
- Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomesAlexander Stark
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
Genome Res 17:1865-79. 2007..For mir-10 in particular, both arms show abundant processing, and both show highly conserved target sites in Hox genes, suggesting a possible cooperation of the two arms, and their role as a master Hox regulator...
- Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosisMingshan Xue
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 64:367-80. 2009..Drosophila cause apparently opposite effects on neurotransmitter release, leading to contradictory hypotheses of Complexin function. Reconstitution experiments with different fusion assays and Complexins also yield conflicting results...
- Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domainsCynthia F Barber
Department of Biology, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
J Cell Biol 187:295-310. 2009..These data suggest that Syt 4 regulates activity-dependent release of postsynaptic retrograde signals that promote synaptic plasticity, similar to the role of Syt 1 as a Ca(2+) sensor for presynaptic vesicle fusion...
- Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growthAvital A Rodal
The Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 28:8316-25. 2008..Together, our results suggest that synaptic growth activated by growth factor signaling is controlled at an endosomal compartment via coordinated Nwk and Cdc42-dependent actin assembly...
- Nervous system targets of RNA editing identified by comparative genomicsBarry Hoopengardner
Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Science 301:832-6. 2003..These results point to a pivotal role for RNA editing in nervous system function...
- Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regionsS Pabst
Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
J Biol Chem 275:19808-18. 2000..Using purified proteins, we have performed a detailed analysis of the structure of complexin and of its interaction with SNARE proteins...
- QUANTITATIVE STUDY OF PRESYNAPTIC FACILITATIONMaria Bykhovskaia; Fiscal Year: 2010..All the developed computational algorithms will be available to other scholars. ..