complexin

Summary

Gene Symbol: complexin
Description: complexin
Alias: BcDNA:GH27718, BcDNA:HL04936, BcDNA:RH26459, BcDNA:RH31085, CG32490, CPX, Cpx, DmCpx, Dmel\CG32490, dmCplx, CG32490 gene product from transcript CG32490-RAB, CG32490-PA, CG32490-PAA, CG32490-PAB, CG32490-PC, CG32490-PE, CG32490-PG, CG32490-PH, CG32490-PI, CG32490-PJ, CG32490-PK, CG32490-PL, CG32490-PM, CG32490-PO, CG32490-PP, CG32490-PS, CG32490-PU, CG32490-PV, CG32490-PW, CG32490-PX, CG32490-PY, CG32490-PZ, cpx-PA, cpx-PAA, cpx-PAB, cpx-PC, cpx-PE, cpx-PG, cpx-PH, cpx-PI, cpx-PJ, cpx-PK, cpx-PL, cpx-PM, cpx-PO, cpx-PP, cpx-PS, cpx-PU, cpx-PV, cpx-PW, cpx-PX, cpx-PY, cpx-PZ
Species: fruit fly

Top Publications

  1. ncbi A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
    Sarah Huntwork
    The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Building 46, Room 3243, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:1235-7. 2007
  2. pmc Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant
    Janani Iyer
    Department of Biology and Center for Molecular Investigation of Neurological Disorders, Penn State University, University Park, PA 16802, United States
    Mol Cell Neurosci 56:244-54. 2013
  3. pmc Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity
    Ramon A Jorquera
    The Picower Institute for Learning and Memory, Departments of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 32:18234-45. 2012
  4. pmc Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity
    Richard W Cho
    Department of Biology and Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Electronic address
    Neuron 88:749-61. 2015
  5. doi Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy
    Valerie Uytterhoeven
    KU Leuven, Center for Human Genetics, Leuven Institute for Neurodegenerative Disease LIND, Laboratory of Neuronal Communication, Herestraat 49, 3000 Leuven, Belgium VIB Center for the Biology of disease, Leuven Institute for Neurodegenerative Disease LIND, Laboratory of Neuronal Communication, Herestraat 49, 3000 Leuven, Belgium
    Neuron 88:735-48. 2015
  6. pmc Dynamic response of RNA editing to temperature in Drosophila
    Leila E Rieder
    BMC Biol 13:1. 2015
  7. pmc Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library
    Nick Lowe
    The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Development 141:3994-4005. 2014
  8. pmc Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo
    Richard W Cho
    Departments of Biology and Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139
    Proc Natl Acad Sci U S A 111:10317-22. 2014
  9. pmc Miniature neurotransmission regulates Drosophila synaptic structural maturation
    Ben Jiwon Choi
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 82:618-34. 2014
  10. pmc Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp
    Maria Bykhovskaia
    Neuroscience Department, Universidad Central del Caribe, Bayamon, Puerto Rico
    Biophys J 105:679-90. 2013

Research Grants

  1. QUANTITATIVE STUDY OF PRESYNAPTIC FACILITATION
    Maria Bykhovskaia; Fiscal Year: 2010

Scientific Experts

  • Richard W Cho
  • Maria Bykhovskaia
  • Ramon Jorquera
  • Alexander Stark
  • Avital A Rodal
  • Mingshan Xue
  • J Troy Littleton
  • Leila E Rieder
  • Valerie Uytterhoeven
  • Ben Jiwon Choi
  • Nick Lowe
  • Lauren K Buhl
  • Janani Iyer
  • Cynthia F Barber
  • Sarah Huntwork
  • Barry Hoopengardner
  • Sabine Kuenen
  • Robert A Reenan
  • Siewert Jan Marrink
  • Jacquelyn S Dorsky
  • RafaĆ«l Wittocx
  • Ali Rezaei
  • Ine Maes
  • Yao Jen Chang
  • Manuel N Melo
  • Sebastian Munck
  • Patrik Verstreken
  • Yiannis A Savva
  • Nikky Corthout
  • Matthew A Reyna
  • Jef Swerts
  • Katarzyna Miskiewicz
  • Elsa Lauwers
  • Wei Jiao
  • Sven Huelsmann
  • Carolina Cela
  • Daniel St Johnston
  • Glynnis Johnson
  • Benedicte Sanson
  • Richard A Baines
  • Johanna S Rees
  • Roger G Phillips
  • J Douglas Armstrong
  • Matthias Landgraf
  • Brian D McCabe
  • Verena Wolfram
  • Vitor Trovisco
  • Celia Hansen
  • Jose P Magbanua
  • Helen Spriggs
  • Jenny Drummond
  • John Roote
  • Rebecca Bastock
  • Helen White-Cooper
  • Kathryn S Lilley
  • Seymour Knowles-Barley
  • Huw Naylor
  • Ying Wu
  • Wendy L Imlach
  • Irina M Armean
  • Mark Grbic
  • Emma Drummond
  • Ed Ryder
  • Steven Russell
  • Michael N Nitabach
  • Giselle A Kuser-Ahnert
  • Sarah Huntwork-Rodriguez
  • Yulia Akbergenova
  • Christopher J Wahlmark
  • Fumiko Kawasaki
  • Dina Volfson
  • S Pabst
  • Jan E Melom
  • Robert Reenan
  • Tarun Bhalla
  • Cynthia Staber
  • W Antonin
  • J Rizo
  • J W Hazzard
  • D Fasshauer
  • R Jahn
  • T C Sudhof

Detail Information

Publications18

  1. ncbi A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
    Sarah Huntwork
    The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Building 46, Room 3243, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:1235-7. 2007
    ..Here we demonstrate that spontaneous release at synapses is regulated by complexin, a SNARE complex-binding protein...
  2. pmc Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant
    Janani Iyer
    Department of Biology and Center for Molecular Investigation of Neurological Disorders, Penn State University, University Park, PA 16802, United States
    Mol Cell Neurosci 56:244-54. 2013
    The COMPLEXIN (CPX) proteins play a critical role in synaptic vesicle fusion and neurotransmitter release...
  3. pmc Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity
    Ramon A Jorquera
    The Picower Institute for Learning and Memory, Departments of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 32:18234-45. 2012
    ..of SNARE-binding proteins have evolved to regulate synaptic exocytosis, including Synaptotagmin (SYT) and Complexin (CPX)...
  4. pmc Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity
    Richard W Cho
    Department of Biology and Department of Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Electronic address
    Neuron 88:749-61. 2015
    ..Here we show that the SNARE fusion clamp Complexin undergoes activity-dependent phosphorylation that alters the basic properties of neurotransmission in Drosophila...
  5. doi Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy
    Valerie Uytterhoeven
    KU Leuven, Center for Human Genetics, Leuven Institute for Neurodegenerative Disease LIND, Laboratory of Neuronal Communication, Herestraat 49, 3000 Leuven, Belgium VIB Center for the Biology of disease, Leuven Institute for Neurodegenerative Disease LIND, Laboratory of Neuronal Communication, Herestraat 49, 3000 Leuven, Belgium
    Neuron 88:735-48. 2015
    ....
  6. pmc Dynamic response of RNA editing to temperature in Drosophila
    Leila E Rieder
    BMC Biol 13:1. 2015
    ..Previous reports suggest that RNA editing is responsive to environmental inputs in the form of temperature alterations. However, the molecular determinants underlying temperature-dependent RNA editing responses are not well understood...
  7. pmc Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library
    Nick Lowe
    The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Development 141:3994-4005. 2014
    ..Our resource substantially increases the number of available protein traps in Drosophila and identifies new markers for cellular organelles and structures. ..
  8. pmc Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo
    Richard W Cho
    Departments of Biology and Brain and Cognitive Sciences, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139
    Proc Natl Acad Sci U S A 111:10317-22. 2014
    b>Complexin (Cpx) is a SNARE-binding protein that regulates neurotransmission by clamping spontaneous synaptic vesicle fusion in the absence of Ca(2+) influx while promoting evoked release in response to an action potential...
  9. pmc Miniature neurotransmission regulates Drosophila synaptic structural maturation
    Ben Jiwon Choi
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 82:618-34. 2014
    ..Our results establish that miniature neurotransmission, a universal but often-overlooked feature of synapses, has unique and essential functions in vivo...
  10. pmc Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp
    Maria Bykhovskaia
    Neuroscience Department, Universidad Central del Caribe, Bayamon, Puerto Rico
    Biophys J 105:679-90. 2013
    ..A cytosolic protein, complexin (Cpx), binds to the SNARE bundle, and its accessory helix (AH) functions to clamp synaptic vesicle fusion...
  11. pmc Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin
    Lauren K Buhl
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States
    Mol Cell Neurosci 52:161-72. 2013
    ..Here, we demonstrate that the C-terminus of Drosophila complexin (DmCpx) regulates localization to synapses and that alternative splicing of the C-terminus can differentially ..
  12. pmc Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release
    Richard W Cho
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell Neurosci 45:389-97. 2010
    The SNARE-binding protein complexin (Cpx) has been demonstrated to regulate synaptic vesicle fusion...
  13. pmc Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    Alexander Stark
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Genome Res 17:1865-79. 2007
    ..For mir-10 in particular, both arms show abundant processing, and both show highly conserved target sites in Hox genes, suggesting a possible cooperation of the two arms, and their role as a master Hox regulator...
  14. pmc Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis
    Mingshan Xue
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 64:367-80. 2009
    ..Drosophila cause apparently opposite effects on neurotransmitter release, leading to contradictory hypotheses of Complexin function. Reconstitution experiments with different fusion assays and Complexins also yield conflicting results...
  15. pmc Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains
    Cynthia F Barber
    Department of Biology, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Cell Biol 187:295-310. 2009
    ..These data suggest that Syt 4 regulates activity-dependent release of postsynaptic retrograde signals that promote synaptic plasticity, similar to the role of Syt 1 as a Ca(2+) sensor for presynaptic vesicle fusion...
  16. pmc Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth
    Avital A Rodal
    The Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 28:8316-25. 2008
    ..Together, our results suggest that synaptic growth activated by growth factor signaling is controlled at an endosomal compartment via coordinated Nwk and Cdc42-dependent actin assembly...
  17. ncbi Nervous system targets of RNA editing identified by comparative genomics
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Science 301:832-6. 2003
    ..These results point to a pivotal role for RNA editing in nervous system function...
  18. ncbi Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions
    S Pabst
    Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    J Biol Chem 275:19808-18. 2000
    ..Using purified proteins, we have performed a detailed analysis of the structure of complexin and of its interaction with SNARE proteins...

Research Grants1

  1. QUANTITATIVE STUDY OF PRESYNAPTIC FACILITATION
    Maria Bykhovskaia; Fiscal Year: 2010
    ..All the developed computational algorithms will be available to other scholars. ..