comm

Summary

Gene Symbol: comm
Description: commissureless
Alias: CG17943, Comm, Dmel\CG17943, CG17943 gene product from transcript CG17943-RB, CG17943-PA, CG17943-PB, comm-PA, comm-PB, commisureless
Species: fruit fly

Top Publications

  1. ncbi Dendritic development: lessons from Drosophila and related branches
    Wesley B Grueber
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Box 0725, San Francisco CA 94143, USA
    Curr Opin Neurobiol 14:74-82. 2004
  2. pmc A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion
    G J Bashaw
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 155:1117-22. 2001
  3. ncbi Crossing the midline: roles and regulation of Robo receptors
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Neuron 28:767-77. 2000
  4. ncbi Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance
    J H Simpson
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 28:753-66. 2000
  5. ncbi Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position
    J H Simpson
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, 519 LSA, University of California, Berkeley CA 94720, USA
    Cell 103:1019-32. 2000
  6. ncbi Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
    G J Bashaw
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 101:703-15. 2000
  7. ncbi Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling
    Andreas Bergmann
    Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 2:159-70. 2002
  8. ncbi Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity
    Tanja A Godenschwege
    Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 22:3117-29. 2002
  9. ncbi Comm sorts robo to control axon guidance at the Drosophila midline
    Krystyna Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 110:415-27. 2002
  10. ncbi Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea
    Camilla Englund
    Umea Centre for Molecular Pathogenesis, Umea University, Sweden
    Development 129:4941-51. 2002

Research Grants

  1. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
  2. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
  3. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
  4. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
  5. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
  6. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
  7. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
  8. Genes Essential To Motor Axon Guidance in Drosophila
    David Van Vactor; Fiscal Year: 2009

Scientific Experts

  • GREG BASHAW
  • YUH N JAN
  • V Auld
  • A W Stoker
  • Susan Parkhurst
  • Guy Tear
  • David L Van Vactor
  • Masaki Hiramoto
  • Krishna Bhat
  • Giorgio F Gilestro
  • Yimiao Ou
  • Alicia Hidalgo
  • Marta Zlatic
  • Akira Chiba
  • Barry J Dickson
  • Timothy A Evans
  • Marie C Reichert
  • Haley E Brown
  • Daniela Rotin
  • Marie Pierre Furrer
  • Krystyna Keleman
  • Marios Georgiou
  • C S Goodman
  • Daan M van den Brink
  • Jana Slováková
  • T Kidd
  • Yunan Zhong
  • Joachim G Schulz
  • Hope A Coleman
  • Iwan R Evans
  • J H Simpson
  • Gabrielle L Boulianne
  • Long Yang
  • David J Brierley
  • Alex Mauss
  • You Seung Kim
  • Bryant Ing
  • Voula Kanelis
  • Tereza Kolesnikov
  • Pauline Henry
  • K S Bland
  • Dhanisha Jhaveri
  • Jessica A Couch
  • Wesley B Grueber
  • Rachel Kraut
  • K Zinn
  • Carole Chotard
  • Vicki L McGovern
  • Anita Hsouna
  • Lila Solnica-Krezel
  • J B Thomas
  • Mark F A VanBerkum
  • Tanja A Godenschwege
  • Jessica Couch
  • Andreas Bergmann
  • Anna Myat
  • Camilla Englund
  • T Hummel
  • Mark Rosenzweig
  • Oishik Banerji
  • Natalia Sánchez-Soriano
  • Ana Carmena
  • Andreas Prokop
  • Stephan Speicher
  • Helga Ceulemans
  • C Klämbt
  • Markus Affolter
  • Leo Nguyen
  • Emmanuel Caussinus
  • Guido David
  • Bassem A Hassan
  • Konstantin G Iliadi
  • Maria F Baietti
  • Alina Shtineman-Kotler
  • Helen Skaer
  • Juan Pablo Labrador
  • B D Wolf
  • J L Fritz
  • Q Sun
  • Nan Hu
  • Rebecca K Chance
  • K Brose
  • S Rajagopalan
  • Will Wood
  • Marco Tripodi
  • Jan Felix Evers
  • Eric Blanc
  • A Schmid
  • David S Garbe
  • H Reichert

Detail Information

Publications80

  1. ncbi Dendritic development: lessons from Drosophila and related branches
    Wesley B Grueber
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, 533 Parnassus Avenue, Box 0725, San Francisco CA 94143, USA
    Curr Opin Neurobiol 14:74-82. 2004
    ..Here, we review some recent advances in our understanding of dendritic development in insects, focusing primarily on insights that have been gained from studies of Drosophila...
  2. pmc A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion
    G J Bashaw
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 155:1117-22. 2001
    ..Surprisingly, evidence from genetic, biochemical, and cell culture experiments suggests that the promotion of axon attraction by GEF64C is dependent on the activation of Rho, but not Rac or Cdc42...
  3. ncbi Crossing the midline: roles and regulation of Robo receptors
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Neuron 28:767-77. 2000
    ..Robo levels are in turn regulated by Comm. Here, we show that the Slit receptors Robo2 and Robo3 ensure the fidelity of this crossing decision: rare crossing ..
  4. ncbi Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance
    J H Simpson
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Neuron 28:753-66. 2000
    ..The robo,robo2 double mutant is largely identical to slit...
  5. ncbi Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position
    J H Simpson
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, 519 LSA, University of California, Berkeley CA 94720, USA
    Cell 103:1019-32. 2000
    ..Precise topography of longitudinal pathways appears to be controlled by a combination of long-range guidance (the Robo code determining region) and short-range guidance (discrete local cues determining specific location within a region)...
  6. ncbi Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
    G J Bashaw
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 101:703-15. 2000
    ..A mutant form of Robo that interferes with Ena binding is partially impaired in Robo function, while a mutation in a conserved cytoplasmic tyrosine that can be phosphorylated by Abl generates a hyperactive Robo receptor...
  7. ncbi Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling
    Andreas Bergmann
    Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 2:159-70. 2002
    ..Therefore, a direct pathway linking a specific extracellular survival factor with a caspase-based death program has been established...
  8. ncbi Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity
    Tanja A Godenschwege
    Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 22:3117-29. 2002
    ..We conclude that axon guidance, dendritic guidance, and synaptogenesis are separable processes and that the different Robo family members affect them distinctly...
  9. ncbi Comm sorts robo to control axon guidance at the Drosophila midline
    Krystyna Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 110:415-27. 2002
    Axon growth across the Drosophila midline requires Comm to downregulate Robo, the receptor for the midline repellent Slit...
  10. ncbi Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea
    Camilla Englund
    Umea Centre for Molecular Pathogenesis, Umea University, Sweden
    Development 129:4941-51. 2002
    ..We propose that the attractive and repulsive tracheal responses to Slit are mediated by different combinations of Robo and Robo2 receptors on the cell surface...
  11. ncbi Genetic specification of axonal arbors: atonal regulates robo3 to position terminal branches in the Drosophila nervous system
    Marta Zlatic
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Neuron 37:41-51. 2003
    ....
  12. ncbi Robo and Frazzled/DCC mediate dendritic guidance at the CNS midline
    Marie Pierre Furrer
    Department of Cell and Structural Biology, University of Illinois, 601 South Goodwin Avenue, Urbana, Illinois 61801, USA
    Nat Neurosci 6:223-30. 2003
    ..Furthermore, we report that each neuron showed a cell-autonomous and independent use of guidance molecules...
  13. ncbi The N-terminal and transmembrane domains of Commissureless are necessary for its function and trafficking within neurons
    Marios Georgiou
    Molecular Neurobiology Group, MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College, London SE1 1UL, UK
    Mech Dev 120:1009-19. 2003
    Commissureless (Comm) is a novel transmembrane molecule necessary both for commissural axons to cross the midline of the Drosophila central nervous system and normal synaptogenesis...
  14. ncbi Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo
    Krystyna Keleman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Nat Neurosci 8:156-63. 2005
    Commissureless (Comm) controls axon guidance across the Drosophila melanogaster midline by regulating surface levels of Robo, the receptor for the midline repellent Slit...
  15. ncbi Commissure formation in the embryonic CNS of Drosophila
    T Hummel
    Institut fur Neurobiologie, Universitat Munster, Badestrasse 9, D 48149 Munster, Germany
    Development 126:771-9. 1999
    ..The results lead to a detailed model relating different cellular functions to axonal patterning at the midline...
  16. ncbi Structural determinants for high-affinity binding in a Nedd4 WW3* domain-Comm PY motif complex
    Voula Kanelis
    Programme in Structural Biology and Biochemistry, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Structure 14:543-53. 2006
    Interactions between the WW domains of Drosophila Nedd4 (dNedd4) and Commissureless (Comm) PY motifs promote axon crossing at the CNS midline and muscle synaptogenesis...
  17. ncbi Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline
    M Seeger
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Neuron 10:409-26. 1993
    ..Here we focus on two new genes: commissureless (comm) and roundabout (robo)...
  18. pmc A frazzled/DCC-dependent transcriptional switch regulates midline axon guidance
    Long Yang
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Science 324:944-7. 2009
    ....
  19. pmc Redundant mechanisms for regulation of midline crossing in Drosophila
    Giorgio F Gilestro
    Research Institute of Molecular Pathology, Vienna, Austria
    PLoS ONE 3:e3798. 2008
    ..in vitro and in vivo assays I mapped the region of Robo that is sufficient and required for its interaction with Comm, its sorting receptor...
  20. ncbi Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 20:25-33. 1998
    ..The robo;comm double-mutant phenotype is identical to robo alone, suggesting that in the absence of robo, comm is no longer ..
  21. ncbi Regulation of commissural axon pathfinding by slit and its Robo receptors
    Barry J Dickson
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Annu Rev Cell Dev Biol 22:651-75. 2006
    ..We hope that this review encourages further efforts to tackle these questions, in the expectation that this system will continue to reveal the general principles of axon pathfinding...
  22. pmc Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster
    Bryant Ing
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Mol Cell Biol 27:481-96. 2007
    Muscle synaptogenesis in Drosophila melanogaster requires endocytosis of Commissureless (Comm), a binding partner for the ubiquitin ligase dNedd4. We investigated whether dNedd4 and ubiquitination mediate this process...
  23. ncbi Slit and Robo control the development of dendrites in Drosophila CNS
    Marie Pierre Furrer
    Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA
    Development 134:3795-804. 2007
    ..Robo is cell-autonomously required in aCC motoneurons to develop dendrites. Our results demonstrate that Slit and Robo control the development of dendrites in the embryonic CNS...
  24. ncbi Slit is the midline repellent for the robo receptor in Drosophila
    T Kidd
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 96:785-94. 1999
    ..Slit appears to function as a short-range repellent controlling axon crossing of the midline and as a long-range chemorepellent controlling mesoderm migration away from the midline...
  25. pmc Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis
    Marta Zlatic
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 7:e1000135. 2009
    ..Together our findings support the idea that axons are delivered to particular regions of the neuropile by their responses to systems of positional cues in each dimension...
  26. ncbi commissureless controls growth cone guidance across the CNS midline in Drosophila and encodes a novel membrane protein
    G Tear
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 16:501-14. 1996
    The commissureless (comm) gene was identified previously in a large-scale screen for mutations that disrupt CNS axon pathways in Drosophila...
  27. ncbi Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline
    Marios Georgiou
    Molecular Neurobiology Group, MRC Centre for Developmental Neurobiology, Guy s Hospital Campus, King s College, London SE1 1UL, UK
    Development 129:2947-56. 2002
    In the absence of Commissureless (Comm) function, axons are unable to extend across the central nervous system midline...
  28. ncbi Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
    G J Bashaw
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 97:917-26. 1999
    ..Robo-Fra (Robo's ectodomain and Fra's cytoplasmic domain) is an attractive Slit receptor; neurons and muscle precursors expressing Robo-Fra are attracted to the Slit-expressing midline...
  29. ncbi Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor
    Anna Myat
    Molecular Neurobiology Group, MRC Centre for Developmental Neurobiology, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, United Kingdom
    Neuron 35:447-59. 2002
    ..Our results show that changes in axonal sensitivity to external cues during pathfinding across the midline makes use of ubiquitin-dependent mechanisms to regulate transmembrane protein levels...
  30. ncbi Commissureless endocytosis is correlated with initiation of neuromuscular synaptogenesis
    B Wolf
    Department of Cell and Structural Biology, University of Illinois, Urbana, IL61801, USA
    Development 125:3853-63. 1998
    We show that the Commissureless (COMM) transmembrane protein is required at neuromuscular synaptogenesis. All muscles in the Drosophila embryo express COMM during the period of motoneuron-muscle interaction...
  31. ncbi The control of dendrite development
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 40:229-42. 2003
    ..In contrast, the control of dendrite development is still much less well understood. However, recent progress has begun to shed light on the molecular mechanisms that orchestrate dendrite growth, arborization, and guidance...
  32. pmc In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains
    Marie C Reichert
    Department of Biological Sciences, University of Arkansas, Fayetteville, AR, 72701, USA
    Neural Dev 11:15. 2016
    ..Multiple structural domains are present in an evolutionarily conserved arrangement in Robo family proteins, but our understanding of the functional importance of individual domains for midline repulsive signaling is limited...
  33. pmc Commissureless regulation of axon outgrowth across the midline is independent of Rab function
    Daan M van den Brink
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS ONE 8:e64427. 2013
    ..In addition we reveal that axon outgrowth of many populations of neurons within the Drosophila central nervous system is also independent of Rab activity...
  34. pmc Slit Binding via the Ig1 Domain Is Essential for Midline Repulsion by Drosophila Robo1 but Dispensable for Receptor Expression, Localization, and Regulation in Vivo
    Haley E Brown
    Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas 72701
    G3 (Bethesda) 5:2429-39. 2015
    ..We show that the Ig1 domain is not required for proper expression, axonal localization, or Commissureless (Comm)-dependent regulation of Robo1 in vivo, and we use a genetic rescue assay to show that Robo1(∆Ig1) is unable to ..
  35. doi The actin-binding protein Canoe/AF-6 forms a complex with Robo and is required for Slit-Robo signaling during axon pathfinding at the CNS midline
    Jana Slováková
    Instituto de Neurociencias, CSIC UMH, 03550 Sant Joan d Alacant, Spain
    J Neurosci 32:10035-44. 2012
    ..Moreover, the commissureless (comm) phenotype (i.e...
  36. pmc Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems
    Timothy A Evans
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Biol 363:266-78. 2012
    ..The ability of Tribolium to organize longitudinal axons into three discrete medial-lateral zones with only two Robo receptors demonstrates that beetle and fly achieve equivalent developmental outcomes using divergent genetic programs...
  37. pmc A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila
    Yunan Zhong
    Program in Cell Biology, The Hospital for Sick Children, Toronto, Canada
    PLoS ONE 6:e27007. 2011
    ..DNedd4 is an E3 ubiquitin ligase comprised of a C2-WW(x3)-Hect domain architecture, which includes several splice isoforms, the most prominent ones are dNedd4-short (dNedd4S) and dNedd4-long (dNedd4Lo)...
  38. pmc Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels
    Joachim G Schulz
    Laboratory of Glycobiology and Developmental Genetics, Katholieke Universiteit Leuven, Herestraat 49 bus 602, KU Leuven, Leuven 3000, Belgium
    EMBO Rep 12:1039-46. 2011
    ..We conclude that Sdc cell autonomously regulates Slit/Robo2 signalling in tracheal cells to guarantee ordered directional migration and branch fusion...
  39. pmc The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline
    Hope A Coleman
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Development 137:2417-26. 2010
    ..Finally, Kuz activity is required for Robo to recruit its downstream signaling partner, Son of sevenless (Sos). These observations support the model that Kuz-directed cleavage is important for Robo receptor activation...
  40. pmc Midline signalling systems direct the formation of a neural map by dendritic targeting in the Drosophila motor system
    Alex Mauss
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 7:e1000200. 2009
    ..We further propose that sets of connections may be specified, at least to a degree, by global patterning systems that deliver pre- and postsynaptic partner terminals to common "meeting regions."..
  41. ncbi NETRIN and SLIT guide salivary gland migration
    Tereza Kolesnikov
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Dev Biol 284:102-11. 2005
    ..We propose that analogous to axon guidance, a balance between chemo-attractants and chemo-repellents is required for the proper migratory path of the developing salivary glands...
  42. ncbi ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized Netrin
    Masaki Hiramoto
    Department of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Nat Neurosci 9:58-66. 2006
    ..The absence of suppression causes the robo phenotype: longitudinal axons project toward the midline, as if running around a roundabout (rotary)...
  43. ncbi "Painting" the target: how local molecular cues define synaptic relationships
    A Chiba
    Department of Cell and Structural Biology, University of Illinois, Urbana, USA
    Bioessays 20:941-8. 1998
    ..In this review, we summarize how such studies are beginning to uncover the repertoire of extrinsic cues that influence the synaptic targeting of a single growth cone...
  44. ncbi Getting a handle on the molecules that guide axons
    E Strauss
    Science 279:481-2. 1998
  45. ncbi Axon guidance: crossing the midline
    J B Thomas
    Molecular Neurobiology Laboratory, The Salk Institute, P O Box 85800, San Diego, California 92186, USA
    Curr Biol 8:R102-4. 1998
    ..Neurons that connect the two sides of the nervous system project their axons across the midline. New studies provide evidence for a conserved gatekeeping mechanism that controls this midline crossing...
  46. ncbi Building a brain: developmental insights in insects
    H Reichert
    Institute of Zoology, University of Basel, Switzerland
    Trends Neurosci 20:258-64. 1997
    ....
  47. pmc Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons
    Yimiao Ou
    Centre for Research in Neuroscience, McGill University, Cedar Ave, Montreal, QC, H3G 1A4, Canada
    Neural Dev 3:16. 2008
    ..To address these issues, we have carried out two comparable gain-of-function screens for genes that influence dendrite morphologies in peripheral dendritic arborisation (da) neurons and central RP2 motor neurons...
  48. ncbi Development and function of embryonic central nervous system glial cells in Drosophila
    C Klämbt
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Dev Genet 18:40-9. 1996
    ..The longitudinal glia prefigure longitudinal axon paths and appear capable of regulating the expression of neuronal antigens. In the following we summarize the knowledge on the function of these glial cells...
  49. ncbi Embryonic development of the Drosophila brain: formation of commissural and descending pathways
    S Therianos
    Laboratory of Neurobiology, Institute of Zoology, University of Basel, Switzerland
    Development 121:3849-60. 1995
    ....
  50. ncbi Genetic and molecular dissection of axon pathfinding in the Drosophila nervous system
    M A Seeger
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104 5073
    Curr Opin Neurobiol 4:56-62. 1994
    ....
  51. ncbi Neurons and glia: team players in axon guidance
    Carole Chotard
    National Institute for Medical Research, Division of Molecular Neurobiology, The Ridgeway, London NW7 1AA, UK
    Trends Neurosci 27:655-61. 2004
    ..Equally, neurons provide crucial information to glia, supporting their migration and correct positioning...
  52. pmc Dendritic targeting in the leg neuropil of Drosophila: the role of midline signalling molecules in generating a myotopic map
    David J Brierley
    Medical Research Council MRC Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS Biol 7:e1000199. 2009
    ....
  53. pmc Interdependence of macrophage migration and ventral nerve cord development in Drosophila embryos
    Iwan R Evans
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
    Development 137:1625-33. 2010
    ....
  54. ncbi To cross or not to cross: a genetic analysis of guidance at the midline
    G Tear
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Perspect Dev Neurobiol 1:183-94. 1993
    ..These phenotypes suggest that these two genes encode important components for growth cone guidance at the midline...
  55. ncbi From growth cone to synapse: the life history of the RP3 motor neuron
    K Broadie
    Department of Zoology, University of Cambridge, UK
    Dev Suppl . 1993
    ..Genetic analysis has revealed mutations in a number of different genes which affect specific aspects of RP3 development from axon outgrowth to synapse formation...
  56. ncbi Apoptosis of the midline glia during Drosophila embryogenesis: a correlation with axon contact
    M J Sonnenfeld
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Development 121:569-78. 1995
    ..One possible explanation is that axon-glia contact or communication promotes survival of the MG and that MG death may result from a competition for available axon contact...
  57. ncbi Glia as mediators of growth cone guidance: studies from insect nervous systems
    V Auld
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Cell Mol Life Sci 55:1377-85. 1999
    ..Recent work in grasshopper, Drosophila and moth nervous system development has underscored the importance of the instructive role glia play during axonal outgrowth...
  58. ncbi Axon pathfinding proceeds normally despite disrupted growth cone decisions at CNS midline
    B D Wolf
    Department of Cell and Structural Biology and Neuroscience Program, University of Illinois, Urbana, IL 61801, USA
    Development 127:2001-9. 2000
    ..Thus, neither the growth cones' particular molecular experience nor the decision at the midline caused by these mutations affects their ability to respond normally to subsequently presented cues...
  59. ncbi Slit proteins: key regulators of axon guidance, axonal branching, and cell migration
    K Brose
    Departments of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 0452, USA
    Curr Opin Neurobiol 10:95-102. 2000
    ....
  60. ncbi Axon routing across the midline controlled by the Drosophila Derailed receptor
    J L Bonkowsky
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, San Diego, California 92186, USA
    Nature 402:540-4. 1999
    ..Our results show that Drl is a novel component in the control of midline crossing...
  61. ncbi Constitutively active myosin light chain kinase alters axon guidance decisions in Drosophila embryos
    You Seung Kim
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    Dev Biol 249:367-81. 2002
    ..These results confirm that proper pathway formation requires careful regulation of MLCK and/or myosin II activity and suggest that regulation occurs in direct response to attractive and repulsive cues...
  62. ncbi Axon targeting meets protein trafficking: Comm takes Robo to the cleaners
    Mark Rosenzweig
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 3:301-2. 2002
    ..at the Drosophila midline relies on dynamic regulation of the guidance receptor Robo by its negative regulator Comm. Recent findings demonstrate that Comm collaborates with the ubiquitin-protein ligase DNedd4 to inhibit Robo ..
  63. ncbi Axon guidance: Comm hither, Robo
    Jessica Couch
    Department of Biology, 071 Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Curr Biol 12:R741-2. 2002
    ..Recent studies have shed new light on the mechanism by which commissural axons change their sensitivity to guidance cues after crossing the midline...
  64. ncbi Fly developments: an introspective
    Susan Parkhurst
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Bioessays 25:87-9. 2003
  65. pmc Roundabout 2 regulates migration of sensory neurons by signaling in trans
    Rachel Kraut
    Division of Biology 114 96, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 14:1319-29. 2004
    ..The development of Drosophila embryonic sense organs provides a neuronal migration paradigm where the in vivo roles of Slit and Robo can be assayed using genetics...
  66. ncbi Axon guidance at the central nervous system midline
    G Tear
    Molecular Neurobiology Group, Guy s Hospital Campus, King s College, London
    Cell Mol Life Sci 55:1365-76. 1999
    ..In this way, axons extend toward or away from the midline and those that do cross change their behaviour to respond to longitudinal signals on the contralateral side...
  67. ncbi Embryo morphogenesis: getting down to cells and molecules
    Lila Solnica-Krezel
    Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    Development 130:4229-33. 2003
  68. ncbi Mosaic analysis reveals a cell-autonomous, neuronal requirement for Commissureless in the Drosophila CNS
    Vicki L McGovern
    Center for Molecular Neurobiology and Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    Dev Genes Evol 213:500-4. 2003
    Commissureless (Comm) is a key regulator of axon guidance at the midline of the Drosophila CNS. Here we report results from mosaic analysis experiments that demonstrate a cell-autonomous, neuronal requirement for Comm...
  69. ncbi Abelson tyrosine kinase is required to transduce midline repulsive cues
    Anita Hsouna
    Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, Michigan 48202, USA
    J Neurobiol 57:15-30. 2003
    ..In comm mutants, where repulsive signals remain elevated, increasing or decreasing Abl activity partially rescues ..
  70. ncbi The middle and the end: slit brings guidance and branching together in axon pathway selection
    D Van Vactor
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 22:649-52. 1999
  71. ncbi Neurobiology. Slit, the midline repellent
    W A Harris
    Nature 398:462-3. 1999
  72. ncbi Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling
    Dhanisha Jhaveri
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400005, India
    Development 131:1903-12. 2004
    ..The location of sensory arbors at distinct positions within the lobe allows short-range interactions with projection neurons leading to formation of the glomeruli...
  73. ncbi Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development
    A Chiba
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign 61801, USA
    Int Rev Neurobiol 43:1-24. 1999
  74. ncbi Derailed axons get on track
    K Zinn
    Nature 402:475-6. 1999
  75. ncbi robo2 and robo3 interact with eagle to regulate serotonergic neuron differentiation
    Jessica A Couch
    Department of Biology, 071 Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Development 131:997-1006. 2004
    ..We propose that post-midline expression of Robo2/3 is part of a signal that regulates serotonergic neuron differentiation and is transduced by the transcription factor Eg...
  76. ncbi Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo
    Q Sun
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Development 127:801-12. 2000
    ..Robo repulsion is downregulated by the Commissureless (Comm) protein, allowing axons to cross the midline...
  77. ncbi Interactive nervous system development: control of cell survival in Drosophila
    Alicia Hidalgo
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Trends Neurosci 25:365-70. 2002
    ..Recent data have finally shown that EGFR (epidermal-growth-factor receptor) ligands function in the Drosophila CNS to maintain glial survival. Trophic interactions are, thus, a general mechanism of nervous system development...
  78. ncbi Neuronal guidance. A genetic perspective
    G Tear
    Department of Biochemistry, Imperial College, London, UK
    Trends Genet 15:113-8. 1999
    ..Here I highlight the part genetic screens and analyses have played in revealing some of the key players in neuronal guidance...
  79. ncbi Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS
    J L Fritz
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Development 127:1991-2000. 2000
    ..These data suggest that Calmodulin and Son of sevenless signaling pathways function to interpret midline repulsive cues which prevent axons crossing the midline...
  80. ncbi Receptor tyrosine phosphatases in axon growth and guidance
    A W Stoker
    Neural Development Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Curr Opin Neurobiol 11:95-102. 2001
    ..Vertebrate RPTPs are now implicated in controlling axon outgrowth, and preliminary evidence suggests that they too may influence axon guidance...

Research Grants8

  1. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
    ..abstract_text> ..
  2. Niemann Pick C disease in Drosophila
    Krishna Bhat; Fiscal Year: 2007
    ..This work will provide insight into the role of these proteins in neurodegenerative diseases and development. ..
  3. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
    ..These studies will help understand pathways that govern the lineage elaboration in the Drosophila CNS as well as in other eukaryotic organisms including humans. ..
  4. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  5. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  6. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  7. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  8. Genes Essential To Motor Axon Guidance in Drosophila
    David Van Vactor; Fiscal Year: 2009
    ..We will use a combination of genetics, cell biology and biochemistry to determine each protein's function in axon guidance and to dissect the signaling mechanisms that regulate the key effector activities. ..