cnc

Summary

Gene Symbol: cnc
Description: cap-n-collar
Alias: 5134, BcDNA:RE05559, CG13826, CG17894, CG43286, CG4566, CG4578, CNC, CNC_DROME, Cnc, CncC, DM12, Dmel\CG43286, Dmel_CG13826, Dmel_CG17894, Nrf2, anon-WO0153538.6, anon-WO0153538.7, cnc-C, l(3)03921, l(3)j5E7, CG43286 gene product from transcript CG43286-RC, CG43286-PA, CG43286-PB, CG43286-PC, CG43286-PD, CG43286-PE, CG43286-PF, CG43286-PG, CG43286-PH, CG43286-PI, CG43286-PJ, CG43286-PK, CG43286-PL, CG43286-PM, CG43286-PN, CG43286-PO, CG43286-PP, Cap 'n' collar, Cap'n'collar, Cap'n'collar B, Cap-and-collar, Cap-n-colar, cap and collar, cap n collar, cnc-PA, cnc-PB, cnc-PC, cnc-PD, cnc-PE, cnc-PF, cnc-PG, cnc-PH, cnc-PI, cnc-PJ, cnc-PK, cnc-PL, cnc-PM, cnc-PN, cnc-PO, cnc-PP
Species: fruit fly

Top Publications

  1. ncbi Control of Drosophila head segment identity by the bZIP homeotic gene cnc
    J Mohler
    Department of Biological Sciences, Barnard College, New York, NY 10027
    Development 121:237-47. 1995
  2. ncbi Stable anterior anchoring of the oocyte nucleus is required to establish dorsoventral polarity of the Drosophila egg
    A Guichet
    Universitat zu Koln, Institut fur Entwicklungsbiologie, Gyrhofstrasse 17, Cologne, 50923, Germany
    Dev Biol 237:93-106. 2001
  3. pmc Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila
    Christine E Hochmuth
    Department of Biology, University of Rochester, River Campus, Rochester, NY 14627, USA
    Cell Stem Cell 8:188-99. 2011
  4. pmc Massively parallel resequencing of the isogenic Drosophila melanogaster strain w(1118); iso-2; iso-3 identifies hotspots for mutations in sensory perception genes
    Adrian E Platts
    The Center for Molecular Medicine and Genetics, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    Fly (Austin) 3:192-203. 2009
  5. pmc Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila
    Gerasimos P Sykiotis
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Cell 14:76-85. 2008
  6. pmc Transcriptional control in the segmentation gene network of Drosophila
    Mark D Schroeder
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, New York, USA
    PLoS Biol 2:E271. 2004
  7. ncbi Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head
    A Veraksa
    Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 127:4023-37. 2000
  8. pmc Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies
    Michael J Williams
    Functional Pharmacology, Department of Neuroscience, Uppsala University Uppsala, Sweden
    Front Aging Neurosci 8:180. 2016
  9. doi Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans
    Ekaterina Lashmanova
    Moscow Institute of Physics and Technology State University, Institutskiy per 9, Dolgoprudny, 141700 Moscow Region, Russian Federation Electronic address
    Pharmacol Res 100:228-41. 2015
  10. pmc Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein
    Nirmalya Chatterjee
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Genet 12:e1006072. 2016

Scientific Experts

  • Niki Chondrogianni
  • Amos Olalekan Abolaji
  • Ulrike Löhr
  • Eran Segal
  • Matthew D Rand
  • Davide Andrenacci
  • L Dubois
  • Dirk Bohmann
  • Gerasimos P Sykiotis
  • Nirmalya Chatterjee
  • Eleni N Tsakiri
  • Michael J Williams
  • Sarah E Lacher
  • Lihong Zhan
  • Ashish Jain
  • Bing Wang
  • Masako Tamada
  • Fumiaki Obata
  • M Rezaul Karim
  • Pei Chen Peng
  • Ekaterina Lashmanova
  • Ana Paula Pegoraro Zemolin
  • Huai Deng
  • W McGinnis
  • Vassilis G Gorgoulis
  • Peter Nagy
  • Ioannis P Trougakos
  • Andrew M Pickering
  • Soojin Hwang
  • Issidora S Papassideri
  • Mohammed Mahidur Rahman
  • Laura M Beaver
  • Pablo Cingolani
  • Maria Cecilia Barone
  • Evgenia Ntini
  • Kristian Björk Grimberg
  • Jyoti R Misra
  • Tommy Kaplan
  • Irwin Jungreis
  • Christine E Hochmuth
  • Susan J Land
  • Xiangyi Lu
  • Douglas M Ruden
  • Sergei Nechaev
  • Adrian E Platts
  • N McGinnis
  • Andrew D Economou
  • E L Wiellette
  • Delphine Coiffier
  • Amparo Garcia-Lopez
  • Bhupendra V Shravage
  • J Mohler
  • Xuetao Sun
  • Navjot Singh
  • A Veraksa
  • Mark D Schroeder
  • Josef Carlsson
  • K W Harding
  • Tabusi Mahebali
  • Loora Laan
  • Min Tian
  • Emelie Perland
  • Ella Potter
  • Daniel Erlandsson
  • Christian Benedict
  • Kerstin Spirohn
  • Robert Frediksson
  • Mikaela M Eriksson
  • Sophie G Martin
  • Michael Boutros
  • Helgi B Schioth
  • Eva Sjøttem
  • Hongyun Shan
  • Masayuki Miura
  • Akira Kobayashi
  • Trond Lamark
  • Oksana Shevchenko
  • Julianne Elvenes
  • Zhaohui Liu
  • Xuting Wang
  • Michelle R Campbell
  • Hiroaki Taniguchi
  • Jack Ansgar Bruun
  • Alex Melerzanov
  • Nadja Katheder
  • Randal S Tibbetts
  • Sergey Leonov
  • Douglas A Bell
  • Terje Johansen
  • Saurabh Sinha

Detail Information

Publications65

  1. ncbi Control of Drosophila head segment identity by the bZIP homeotic gene cnc
    J Mohler
    Department of Biological Sciences, Barnard College, New York, NY 10027
    Development 121:237-47. 1995
    Mutational analysis of cap'n'collar (cnc), a bZIP transcription factor closely related to the mammalian erythroid factor NF-E2 (p45), indicates that it acts as a segment-specific selector gene controlling the identity of two cephalic ..
  2. ncbi Stable anterior anchoring of the oocyte nucleus is required to establish dorsoventral polarity of the Drosophila egg
    A Guichet
    Universitat zu Koln, Institut fur Entwicklungsbiologie, Gyrhofstrasse 17, Cologne, 50923, Germany
    Dev Biol 237:93-106. 2001
    ..cap 'n' collar mutants, therefore, allow for the study of the influence of Grk signal duration on DV patterning in the follicular epithelium...
  3. pmc Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila
    Christine E Hochmuth
    Department of Biology, University of Rochester, River Campus, Rochester, NY 14627, USA
    Cell Stem Cell 8:188-99. 2011
    ..Here we show that Nrf2, a master regulator of the cellular redox state, specifically controls the proliferative activity of ISCs, ..
  4. pmc Massively parallel resequencing of the isogenic Drosophila melanogaster strain w(1118); iso-2; iso-3 identifies hotspots for mutations in sensory perception genes
    Adrian E Platts
    The Center for Molecular Medicine and Genetics, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA
    Fly (Austin) 3:192-203. 2009
    ..Because of the dramatic increase in power in using isogenic lines rather than outbred individuals, the SNP information should be valuable as a test bed for understanding genotype-by-environment interactions in human population studies...
  5. pmc Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila
    Gerasimos P Sykiotis
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Cell 14:76-85. 2008
    Keap1/Nrf2 signaling defends organisms against the detrimental effects of oxidative stress and has been suggested to abate its consequences, including aging-associated diseases like neurodegeneration, chronic inflammation, and cancer...
  6. pmc Transcriptional control in the segmentation gene network of Drosophila
    Mark D Schroeder
    Laboratory of Developmental Neurogenetics, Rockefeller University, New York, New York, USA
    PLoS Biol 2:E271. 2004
    ..The study demonstrates that computational methods are a powerful complement to experimental approaches in the analysis of transcription networks...
  7. ncbi Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head
    A Veraksa
    Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    Development 127:4023-37. 2000
    ....
  8. pmc Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies
    Michael J Williams
    Functional Pharmacology, Department of Neuroscience, Uppsala University Uppsala, Sweden
    Front Aging Neurosci 8:180. 2016
    ..The fact that neuroprotective pathways remain upregulated in middle-aged flies beyond sleep fragmentation suggests it might represent a strong stressor for the brain during later life. ..
  9. doi Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans
    Ekaterina Lashmanova
    Moscow Institute of Physics and Technology State University, Institutskiy per 9, Dolgoprudny, 141700 Moscow Region, Russian Federation Electronic address
    Pharmacol Res 100:228-41. 2015
    ..elegans were revealed only for fucoxanthin. In presence of carotenoids decreased flies' fecundity, increased spontaneous locomotor activity and resistance to oxidative stress were detected...
  10. pmc Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein
    Nirmalya Chatterjee
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Genet 12:e1006072. 2016
    ..of the BET protein family in Drosophila, Fs(1)h, as an inhibitor of the stress responsive transcription factor CncC, the fly ortholog of Nrf2...
  11. pmc Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift
    Pablo Cingolani
    Institute of Environmental Health Sciences, Wayne State University Detroit, MI, USA
    Front Genet 3:35. 2012
    ..This technique can also be used to characterize the variety of mutations generated by genotoxic chemicals...
  12. pmc A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster
    Andrew M Pickering
    Ethel Percy Andrus Gerontology Center of Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089 0191, USA
    J Exp Biol 216:543-53. 2013
    In mammalian cells, hydrogen peroxide (H(2)O(2))-induced adaptation to oxidative stress is strongly dependent on an Nrf2 transcription factor-mediated increase in the 20S proteasome...
  13. pmc Circadian regulation of glutathione levels and biosynthesis in Drosophila melanogaster
    Laura M Beaver
    Department of Zoology, Oregon State University, Corvallis, OR, USA
    PLoS ONE 7:e50454. 2012
    ..Together, these data suggest that the circadian system modulates pathways involved in production and utilization of glutathione...
  14. pmc Square Cell Packing in the Drosophila Embryo through Spatiotemporally Regulated EGF Receptor Signaling
    Masako Tamada
    Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Dev Cell 35:151-61. 2015
    ..The basic leucine zipper transcriptional regulator Cnc is necessary and sufficient to produce a square cell grid in the presence of a midline signal provided by the EGF ..
  15. pmc Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress
    Eleni N Tsakiri
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    FASEB J 27:2407-20. 2013
    ..Finally, inducible Nrf2 activation in transgenic flies promoted youthful proteasome expression levels in the aged soma, suggesting that age-..
  16. pmc Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes
    Mohammed Mahidur Rahman
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Aging Cell 12:554-62. 2013
    ..In studies on the Drosophila Nrf2 transcription factor CncC, we have investigated possible causes for this loss of stress resistance and its ..
  17. pmc Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO
    Soojin Hwang
    Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
    PLoS Genet 9:e1003412. 2013
    ....
  18. pmc Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging
    Eleni N Tsakiri
    Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece
    Aging Cell 12:802-13. 2013
    ..proteostasis network by reactive oxygen species that originated from malfunctioning mitochondria and triggered an Nrf2-dependent upregulation of the proteasome subunits...
  19. pmc Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster
    Peter Nagy
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    PLoS Genet 9:e1003664. 2013
    ..results in cell-autonomous increases in cell growth, autophagy induction, and p62 (Ref2P)-mediated activation of Nrf2 (cnc), a transcription factor promoting antioxidant responses...
  20. doi Toxicity induced by Prasiola crispa to fruit fly Drosophila melanogaster and cockroach Nauphoeta cinerea: evidence for bioinsecticide action
    Ana Paula Pegoraro Zemolin
    a Campus São Gabriel, Universidade Federal do Pampa, São Gabriel, Rio Grande do Sul, Brazil
    J Toxicol Environ Health A 77:115-24. 2014
    ..The insecticidal properties of PcE may be related to changes in important antioxidant/detoxifying systems, as well as to changes in insect cardiac function. ..
  21. doi Proteasome activation delays aging in vitro and in vivo
    Niki Chondrogianni
    National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry, and Biotechnology, 116 35 Athens, Greece Electronic address
    Free Radic Biol Med 71:303-20. 2014
    ..This review article reports on the means of function of these proteasome activators and how they regulate aging in various species. ..
  22. pmc Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation
    Huai Deng
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Development 141:3277-88. 2014
    ..Drosophila Keap1 (dKeap1)-CncC complexes localized to the nucleus and bound chromatin loci that were not bound preferentially by dKeap1 or CncC ..
  23. pmc Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration
    Lihong Zhan
    Department of Human Oncology, Program in Molecular and Cellular Pharmacology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Hum Mol Genet 24:757-72. 2015
    ....
  24. pmc Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan
    Fumiaki Obata
    Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Commun 6:8332. 2015
    ..Our study suggests that regulation of SAM levels by Gnmt is a key component of lifespan extension. ..
  25. pmc Incorporating chromatin accessibility data into sequence-to-expression modeling
    Pei Chen Peng
    Department of Computer Science, University of Illinois at Urbana Champaign, Urbana, Illinois
    Biophys J 108:1257-67. 2015
    ..It also calls for future advances in modeling accessibility levels from sequence and the transregulatory context, so as to predict accurately the effect of cis and trans perturbations on gene expression. ..
  26. pmc p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB
    Ashish Jain
    From the Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway and
    J Biol Chem 290:14945-62. 2015
    ..promoter also contains a functional antioxidant response element that is directly bound by the NRF2 orthologue, CncC, which can induce ref(2)P expression along with the oxidative stress-associated gene gstD1...
  27. doi Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to α-synuclein in Drosophila
    Bing Wang
    Department of Human Anatomy and Cytoneurobiology, Medical School of Soochow University, Suzhou, P R China
    Biochem Cell Biol 93:351-8. 2015
    ..the increases in ROS levels in the A53T flies and improved the neurodegenerative changes by activating the Nrf2/antioxidant response element signaling pathway...
  28. doi Constitutive activation of Drosophila CncC transcription factor reduces lipid formation in the fat body
    M Rezaul Karim
    Laboratory for Genetic Code, Graduate School of Life and Medical Sciences, Doshisha University, Japan
    Biochem Biophys Res Commun 463:693-8. 2015
    Accumulating evidence indicates that the vertebrate stress-response transcription factors Nrf1 and Nrf2 are involved in hepatic lipid metabolism...
  29. pmc Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster
    Amos O Abolaji
    Drug Metabolism and Molecular Toxicology Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria Departamento de Bioquimica e Biologia Molecular, Bioquimica Toxicologica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS 97105 900, Brazil Electronic address
    Redox Biol 5:328-39. 2015
    ..of the genes encoding the proteins superoxide dismutase (SOD1), kelch-like erythroid-derived cap-n-collar (CNC) homology (ECH)-associated protein 1 (Keap-1), mitogen activated protein kinase 2 (MAPK-2), catalase, Cyp18a1, ..
  30. pmc Beyond antioxidant genes in the ancient Nrf2 regulatory network
    Sarah E Lacher
    Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA
    Free Radic Biol Med 88:452-65. 2015
    b>Nrf2, a basic leucine zipper transcription factor encoded by the gene NFE2L2, is a master regulator of the transcriptional response to oxidative stress...
  31. ncbi Embryonic expression pattern of the Drosophila Kallmann syndrome gene kal-1
    Davide Andrenacci
    Institute of Genetics and Biophysics, A Buzzati Traverso, CNR Via P Castellino 111, 80131 Napoli, Italy
    Gene Expr Patterns 5:67-73. 2004
    ..By studying the expression in Dfd and cnc homeotic mutants, we found that these ectodermal cells derive from the anterior and posterior mandibular segment, ..
  32. pmc Quantitative models of the mechanisms that control genome-wide patterns of transcription factor binding during early Drosophila development
    Tommy Kaplan
    Department of Molecular and Cell Biology, California Institute of Quantitative Biosciences, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 7:e1001290. 2011
    ....
  33. pmc Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease
    Maria Cecilia Barone
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dis Model Mech 4:701-7. 2011
    ..The transcription factor Nrf2, a conserved global regulator of cellular antioxidant responses, has been implicated in neuroprotection against PD ..
  34. pmc Transcriptional regulation of xenobiotic detoxification in Drosophila
    Jyoti R Misra
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Genes Dev 25:1796-806. 2011
    ..In contrast, little is known about this pathway in insects. Here we show that the Drosophila Nrf2 (NF-E2-related factor 2) ortholog CncC (cap 'n' collar isoform-C) is a central regulator of xenobiotic ..
  35. pmc Evidence of abundant stop codon readthrough in Drosophila and other metazoa
    Irwin Jungreis
    MIT Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 21:2096-113. 2011
    ....
  36. doi Second order regulator Collier directly controls intercalary-specific segment polarity gene expression
    Evgenia Ntini
    Department of Developmental Biology, Johann Friedrich Blumenbach Institute of Zoology und Anthropology, Georg August University Gottingen, GZMB, Ernst Caspari Haus, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Dev Biol 360:403-14. 2011
    ....
  37. pmc Methylmercury disruption of embryonic neural development in Drosophila
    Matthew D Rand
    Department of Anatomy and Neurobiology, College of Medicine, University of Vermont, United States
    Neurotoxicology 30:794-802. 2009
    ..Ectopic expression of the Nrf2 transcription factor in embryos, a core factor in the antioxidant response element (ARE) pathway, enhances ..
  38. pmc A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture
    Nirmalya Chatterjee
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 7:e34063. 2012
    ..and compare the activity and signal response profiles of two stress inducible transcription factors, AP-1 and Nrf2. To complement the transgenic reporter fly lines, tissue culture assays were developed in which the same synthetic ..
  39. pmc Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila
    Sergei Nechaev
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Science 327:335-8. 2010
    ..These results indicate that the intrinsic efficiency of early elongation can greatly affect gene expression...
  40. pmc The Drosophila maternal effect locus deadhead encodes a thioredoxin homolog required for female meiosis and early embryonic development
    H K Salz
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106 4955
    Genetics 136:1075-86. 1994
    ..Whether the head defect indicates an additional function or is an indirect consequence of earlier defects remains to be determined...
  41. ncbi knot is required for the hypopharyngeal lobe and its derivatives in the Drosophila embryo
    M Seecoomar
    Department of Biological Sciences, Barnard College, 3009 Broadway, New York, NY 10027 USA
    Mech Dev 91:209-15. 2000
    ..kn is required for the activation of cnc (cap'n'collar, a bZIP homeotic selector gene) in the progenitors of hypopharyngeal lobe...
  42. ncbi spen encodes an RNP motif protein that interacts with Hox pathways to repress the development of head-like sclerites in the Drosophila trunk
    E L Wiellette
    Department of Biology, University of California at San Diego, La Jolla, CA, 92093
    Development 126:5373-85. 1999
    ..This raises the intriguing possibility that the Spen RNP protein might integrate signals from both the Raf and Hox pathways...
  43. ncbi Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment
    M Crozatier
    Centre de Biologie du Developpement, UMR 5547, CNRS Université Paul Sabatier, 31062 TOULOUSE 04 cedex, France
    Development 126:4385-94. 1999
    ..both of the segment polarity genes hedgehog, engrailed, and wingless, and of the segment identity gene cap and collar. The parasegmental register of col activation is controlled by the combined activities of the head-gap genes ..
  44. ncbi Hox genes differentially regulate Serrate to generate segment-specific structures
    E L Wiellette
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    Development 126:1985-95. 1999
    ..However, Serrate does not require rhomboid function in the maxillary segment, suggesting that the Hox-Serrate pathway to segment-specific morphogenesis can be linked to more than one downstream function...
  45. ncbi A cap 'n' collar protein isoform contains a selective Hox repressor function
    N McGinnis
    Department of Biology, University of California, San Diego, La Jolla, CA, 92093, USA
    Development 125:4553-64. 1998
    ..Of the three Cnc protein isoforms, CncB is expressed in a localized pattern in mandibular and labral cells of the head during mid-..
  46. ncbi A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development
    G Gellon
    Department of Biology, Yale University, New Haven, CT 06520 8114, USA
    Development 124:3321-31. 1997
    ..We propose that apt acts in parallel to, or as a cofactor with, HOX proteins to regulate homeotic targets in the ventral gnathal region...
  47. ncbi Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase
    K G Hales
    Department of Genetics, Stanford University School of Medicine, California 94305, USA
    Cell 90:121-9. 1997
    ..Fzo has homologs of unknown function in mammals, nematodes, and yeast...
  48. ncbi The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype
    J D Pederson
    Department of Genetics, North Carolina State University, Raleigh 27695 7614, USA
    Dev Biol 180:131-42. 1996
    ..The observed morphological characteristics and gene expression patterns of various mutant embryos indicate a loss of segmental identity rather than a transformation...
  49. ncbi Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster
    Navjot Singh
    Molecular Genetics Program, Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Dev Biol 278:242-54. 2005
    ..Bicoid's activity, therefore, depends not only on its concentration gradient, but also on its interactions with modifier proteins within spatially restricted domains...
  50. pmc A screen for modifiers of Deformed function in Drosophila
    K W Harding
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven Connecticut 06520 8114, USA
    Genetics 140:1339-52. 1995
    ..Two of these genes, cap 'n' collar and defaced, have defects in embryonic head development that are similar to defects seen in loss of function Deformed mutants...
  51. pmc The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein
    J Mohler
    Barnard College, New York, New York 10027
    Genetics 131:377-88. 1992
    ....
  52. ncbi Persistence of Hunchback in the terminal region of the Drosophila blastoderm embryo impairs anterior development
    F Janody
    LGPD, IBDM, Parc Scientifique de Luminy, Case 907, Marseille, France
    Development 127:1573-82. 2000
    ..They suggest that the repression of hunchback by torso is required to prevent this antagonism and to promote anterior terminal development, depending mostly on bicoid activity...
  53. ncbi Pondering the procephalon: the segmental origin of the labrum
    M S Haas
    USDA, ARS, Grain Marketing and Production Research Center, Manhattan, KS 66502, USA
    Dev Genes Evol 211:89-95. 2001
    ..This model appears to explain a wider variety of insect head segmentation phenomena. Embryological, histological, neurological and molecular evidence supporting the new model is reviewed...
  54. ncbi The COE--Collier/Olf1/EBF--transcription factors: structural conservation and diversity of developmental functions
    L Dubois
    Centre de Biologie du Developpement, UMR 5547, CNRS Université Paul Sabatier, 118 route de Narbonne 31062 Toulouse cedex 04, France
    Mech Dev 108:3-12. 2001
    ..We also discuss the existence of an evolutionarily conserved pathway linking Notch signalling and COE regulatory functions in various developmental decisions...
  55. pmc Glial and neuronal functions of the Drosophila homolog of the human SWI/SNF gene ATR-X (DATR-X) and the jing zinc-finger gene specify the lateral positioning of longitudinal glia and axons
    Xuetao Sun
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    Genetics 173:1397-415. 2006
    ....
  56. ncbi The role of Dpp and its inhibitors during eggshell patterning in Drosophila
    Bhupendra V Shravage
    Institute of Developmental Biology, University of Cologne, Gyrhofstr 17, D 50931, Germany
    Development 134:2261-71. 2007
    ....
  57. ncbi Common functions of central and posterior Hox genes for the repression of head in the trunk of Drosophila
    Delphine Coiffier
    Institut de Biologie du Developpement de Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Case 907 Parc Scientifique de Luminy, 13288 Marseille Cedex 09, France
    Development 135:291-300. 2008
    ..We propose that an evolutionary early function of Hox genes was to modify primitive head morphology with novel functions specialising the trunk appearing later on...
  58. pmc Genetic and chemical modifiers of a CUG toxicity model in Drosophila
    Amparo Garcia-Lopez
    Department of Genetics, University of Valencia, Burjasot, Spain
    PLoS ONE 3:e1595. 2008
    ..These findings provide new insights into the DM1 phenotype, and suggest novel candidates for DM1 treatments...
  59. doi Comparative gene expression in the heads of Drosophila melanogaster and Tribolium castaneum and the segmental affinity of the Drosophila hypopharyngeal lobes
    Andrew D Economou
    Research Department of Genetics, Evolution and Environment, Darwin Building, University College London, Gower Street, London WC1E 6BT, UK
    Evol Dev 11:88-96. 2009
    ..We propose that the difficulties in interpreting the Drosophila head result from a topological shift in the Drosophila embryonic head, associated with the derived process of head involution...
  60. pmc Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains
    Ulrike Löhr
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 106:21695-700. 2009
    ..We conclude that the spatial domains of head gene expression are determined by Bcd in concert with Tor-dependent repressors...
  61. pmc Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome
    Kristian Björk Grimberg
    Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
    Mol Cell Biol 31:897-909. 2011
    ..This screen identified Cnc (cap 'n' collar [CNC]; basic region leucine zipper) as a candidate transcriptional regulator of proteasome ..
  62. ncbi The identification of novel genes required for Drosophila anteroposterior axis formation in a germline clone screen using GFP-Staufen
    Sophie G Martin
    The Wellcome Trust Cancer Research UK Institute and the Department of Genetics, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QR, UK
    Development 130:4201-15. 2003
    ..As orb, yps and spn-E encode RNA-binding proteins, they may regulate the translation of unidentified RNAs necessary for the polarisation of the microtubule cytoskeleton...
  63. doi Predicting expression patterns from regulatory sequence in Drosophila segmentation
    Eran Segal
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 451:535-40. 2008
    ..Our computational framework is generally applicable to most protein-DNA interaction systems...