chico

Summary

Gene Symbol: chico
Description: CG5686 gene product from transcript CG5686-RB
Alias: BcDNA.GH11263, BcDNA:GH11263, CG5686, CHICO, Chico, Dmel\CG5686, IRS, IRS/chico, anon-WO0078940.1, anon-WO0078940.4, chic, dIRS, fs(2)4, fs(2)ry4, CG5686 gene product from transcript CG5686-RB, CG5686-PA, CG5686-PB, CG5686-PC, chico-PA, chico-PB, chico-PC, flipper, insulin receptor substrate, insulin-like receptor substrate
Species: fruit fly

Top Publications

  1. ncbi The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
    J R Riesgo-Escovar
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 10:2759-68. 1996
  2. ncbi Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
    R Bohni
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 97:865-75. 1999
  3. ncbi PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
    H Huang
    Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536 0812, USA
    Development 126:5365-72. 1999
  4. pmc Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
    D C Goberdhan
    Research School of Biosciences, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Genes Dev 13:3244-58. 1999
  5. ncbi Measuring dimensions: the regulation of size and shape
    S J Day
    28 St Oswalds Road, York, YO10 4PF, UK
    Development 127:2977-87. 2000
  6. pmc Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    S Oldham
    Zoologisches Institut, Universitat Zurich, 8057 Zurich, Switzerland
    Genes Dev 14:2689-94. 2000
  7. pmc Genetic control of size in Drosophila
    S Oldham
    Zoological Institute, University of Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 355:945-52. 2000
  8. ncbi Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis
    D Drummond-Barbosa
    Howard Hughes Medical Institute Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 231:265-78. 2001
  9. ncbi Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
  10. ncbi dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
    Thomas Radimerski
    Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nat Cell Biol 4:251-5. 2002

Research Grants

Patents

  1. In vivo insect model system for type-2 diabetes

Scientific Experts

Detail Information

Publications105 found, 100 shown here

  1. ncbi The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
    J R Riesgo-Escovar
    Zoologisches Institut, Universitat Zurich, Switzerland
    Genes Dev 10:2759-68. 1996
    ..Although DJNK efficiently phosphorylates DJun in vitro, bsk function is not required for the specification of cell fate in the developing eye, a process that requires MAP kinase and DJun function...
  2. ncbi Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
    R Bohni
    Zoologisches Institut, Universitat Zurich, Switzerland
    Cell 97:865-75. 1999
    The control of growth is fundamental to the developing metazoan. Here, we show that CHICO, a Drosophila homolog of vertebrate IRS1-4, plays an essential role in the control of cell size and growth...
  3. ncbi PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
    H Huang
    Howard Hughes Medical Institute and Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536 0812, USA
    Development 126:5365-72. 1999
    ....
  4. pmc Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
    D C Goberdhan
    Research School of Biosciences, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Genes Dev 13:3244-58. 1999
    ..to the Drosophila Class I phosphatidylinositol 3-kinase, Dp110, and its upstream activator Chico, an insulin receptor substrate homolog...
  5. ncbi Measuring dimensions: the regulation of size and shape
    S J Day
    28 St Oswalds Road, York, YO10 4PF, UK
    Development 127:2977-87. 2000
    ..We discuss a hypothesis that the local steepness of a morphogen gradient is a measure of length in one axis, a measure that is used to determine whether there will be net growth or not...
  6. pmc Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    S Oldham
    Zoologisches Institut, Universitat Zurich, 8057 Zurich, Switzerland
    Genes Dev 14:2689-94. 2000
    ..These results are consistent with dTOR residing on a parallel amino acid sensing pathway...
  7. pmc Genetic control of size in Drosophila
    S Oldham
    Zoological Institute, University of Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 355:945-52. 2000
    ..In this article we will review recent evidence from vertebrates and particularly from Drosophila that implicates insulin/insulin-like growth factor-I and other growth pathways in the control of cell, organ and body size...
  8. ncbi Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis
    D Drummond-Barbosa
    Howard Hughes Medical Institute Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, Maryland 21210, USA
    Dev Biol 231:265-78. 2001
    ....
  9. ncbi Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
    The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway...
  10. ncbi dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
    Thomas Radimerski
    Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nat Cell Biol 4:251-5. 2002
    ..Effectors of this pathway include Chico (the insulin receptor substrate homologue), dPI(3)K, dPKB, dPTEN, and dS6K...
  11. ncbi Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    Hugo Stocker
    Zoologisches Institut der Universitat Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Science 295:2088-91. 2002
    ..Thus, Akt appears to be the only critical target activated by increased PIP3 concentrations in Drosophila...
  12. ncbi Dietary restriction in long-lived dwarf flies
    David J Clancy
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 296:319. 2002
  13. ncbi The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels
    Sean Oldham
    Universitat Zurich, Zoologisches Institut, Winterthurerstrasse 190, CH 8057, Switzerland
    Development 129:4103-9. 2002
    ..We show that in Drosophila mutating the consensus binding site for the Ras pathway adaptor Drk/Grb2 in Chico/IRS does not interfere with growth whereas mutating the binding sites of the PI 3-kinase adaptor p60 completely ..
  14. ncbi Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
    Sean Oldham
    The Burnham Institute, La Jolla, CA 92037, USA
    Trends Cell Biol 13:79-85. 2003
    ..This review summarizes current studies primarily from Drosophila regarding the function of the insulin/IGF system in the control of growth...
  15. ncbi The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island, USA
    Aging Cell 1:75-80. 2002
    ..this sex-difference, we conducted a large-scale demographic study with three new isogenic strains of alleles at chico, the insulin-receptor substrate homologue...
  16. pmc The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    Martin A Jünger
    Zoologisches Institut, Universitat Zurich, Winterthurerstr, 190, CH 8057 Zurich, Switzerland
    J Biol 2:20. 2003
    ..In this study, we present a genetic characterization of dFOXO, the only Drosophila FOXO ortholog...
  17. ncbi Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster
    Meng Ping Tu
    Department of Ecology and Evolutionary Biology, Box G W, Brown University, Providence, RI 02912, USA
    Aging Cell 2:327-33. 2003
    ..Homozygotes of insulin-like receptor (InR) and insulin-like receptor substrate (chico) delay time to eclosion, reduce body size, decrease reproduction and increase life span...
  18. ncbi Tuberous sclerosis complex: from Drosophila to human disease
    Duojia Pan
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Trends Cell Biol 14:78-85. 2004
    ..Here, we review these exciting developments with an emphasis on Drosophila studies and discuss how Drosophila can be a powerful model system for an understanding of the molecular mechanisms of the activity of human disease genes...
  19. ncbi Insulin regulation of heart function in aging fruit flies
    Robert J Wessells
    The Burnham Institute, Center for Neuroscience and Aging, 10901 Torrey Pines Road, La Jolla, California 92037, USA
    Nat Genet 36:1275-81. 2004
    ..systemic levels of insulin-like peptides are reduced and by mutations of the only receptor, InR, or its substrate, chico. Moreover, interfering with InR signaling exclusively in the heart, by overexpressing the phosphatase dPTEN or the ..
  20. ncbi Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster
    Ammon B Corl
    Department of Anatomy and Programs, University of California, San Francisco, California 94143 2822, USA
    Nat Neurosci 8:18-9. 2005
    ..These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug...
  21. ncbi The plasticity of aging: insights from long-lived mutants
    Cynthia Kenyon
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
    Cell 120:449-60. 2005
    ..Many mutations affecting longevity pathways delay age-related disease, and the molecular analysis of these pathways is leading to a mechanistic understanding of how these two processes--aging and disease susceptibility--are linked...
  22. ncbi Sex and death: what is the connection?
    Linda Partridge
    UCL Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    Cell 120:461-72. 2005
    ..Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits...
  23. ncbi Calorie restriction--the SIR2 connection
    Leonard Guarente
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell 120:473-82. 2005
    ....
  24. ncbi Susi, a negative regulator of Drosophila PI3-kinase
    Franz Wittwer
    Zoologisches Institut, Universitat Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Dev Cell 8:817-27. 2005
    ..The fact that Susi is expressed in a circadian rhythm, with highest levels during the night, suggests that Susi attenuates insulin signaling during the fasting period...
  25. pmc The temporal requirements for insulin signaling during development in Drosophila
    Alexander W Shingleton
    Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Biol 3:e289. 2005
    ..We hypothesize that the insulin-signaling pathway controls such diverse effects as total developmental time, total body size and organ size through its effects on the rate of cell growth, and proliferation in different organs...
  26. ncbi Signaling and function of insulin-like peptides in insects
    Qi Wu
    Department of Cellular Biology, University of Georgia, Athens
    Annu Rev Entomol 51:1-24. 2006
    ....
  27. pmc TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity
    Qian Yang
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 103:6811-6. 2006
    ..Our observations suggest that TSC1/2 and Rheb have different effects on the activity of TORC1 and -2, further supporting the complexity of TOR regulation...
  28. pmc Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation
    Xi Luo
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    EMBO J 26:380-90. 2007
    ..These data suggest that integrating stress and survival signals through Foxo drives the decision between cell death and repair of damaged cells in vivo...
  29. ncbi Dynamics of the action of dFOXO on adult mortality in Drosophila
    Maria E Giannakou
    Centre for Research on Ageing, Department of Biology, University College London, London, UK
    Aging Cell 6:429-38. 2007
    ..The decreased mortality and increased lifespan of dFOXO overexpressing flies was uncoupled from any effect on female fecundity and from expression levels of Drosophila insulin-like peptides in the brain...
  30. ncbi Quantitative proteomic analysis of protein complexes: concurrent identification of interactors and their state of phosphorylation
    Delphine Pflieger
    Institute for Molecular Systems Biology, ETH, 8093 Zurich, Switzerland
    Mol Cell Proteomics 7:326-46. 2008
    ..of samples immunopurified from Drosophila melanogaster cells expressing an epitope-tagged form of the insulin receptor substrate homologue Chico...
  31. pmc Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila
    Hwei Jan Hsu
    Department of Cell and Developmental Biology, 4120B Medical Research Building III, Vanderbilt University Medical Center, 465 21st Avenue South, Nashville, TN 37232 8240, USA
    Dev Biol 313:700-12. 2008
    ..Moreover, the retained ability of GSC tumors to respond to diet parallels the long known connections between diet, insulin signaling, and cancer risk in humans...
  32. pmc Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    Basil Honegger
    Zoological Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol 7:10. 2008
    ..In mammals, insulin-like growth factor binding proteins (IGFBPs) bind IGFs with high affinity and modulate their mitogenic, anti-apoptotic and metabolic actions, but no functional homologs have been identified in invertebrates so far...
  33. pmc Tissue damage-induced intestinal stem cell division in Drosophila
    Alla Amcheslavsky
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Stem Cell 4:49-61. 2009
    ..By using this newly established system of intestinal stem cell proliferation and tissue regeneration, we find that the insulin receptor signaling pathway is required for intestinal stem cell division...
  34. pmc Insulin levels control female germline stem cell maintenance via the niche in Drosophila
    Hwei Jan Hsu
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 8240, USA
    Proc Natl Acad Sci U S A 106:1117-21. 2009
    ..These results underscore the importance of systemic factors for the regulation of stem cell niches and, thereby, of stem cell numbers...
  35. pmc Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster
    Sergey V Nuzhdin
    Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA
    BMC Genomics 10:124. 2009
    ..We focus on the latter problem by describing genetic variation in transcript levels of genes in the InR/TOR pathway among 72 Drosophila melanogaster genotypes...
  36. pmc Quantification of food intake in Drosophila
    Richard Wong
    Institute of Healthy Ageing, and GEE, University College London, London, UK
    PLoS ONE 4:e6063. 2009
    ..that alterations in food intake are not induced by dietary restriction or by a null mutation of the fly insulin receptor substrate chico...
  37. pmc The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway
    Christian Werz
    Institute of Molecular Systems Biology, Zurich, Switzerland
    PLoS Genet 5:e1000596. 2009
    ..phosphoinositide 3-kinase (PI3K) in the IIS cascade, at the same level as chico (encoding the single fly insulin receptor substrate [IRS] homolog)...
  38. doi Molecular mechanisms of metabolic regulation by insulin in Drosophila
    Aurelio A Teleman
    German Cancer Research Center Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Biochem J 425:13-26. 2009
    ..I discuss both the intracellular signalling network, as well as the communication between organs in the fly...
  39. pmc Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
    Ivana Bjedov
    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, UK
    Cell Metab 11:35-46. 2010
    ..Rapamycin could increase life span of weak insulin/Igf signaling (IIS) pathway mutants and of flies with life span maximized by dietary restriction, indicating additional mechanisms...
  40. pmc SH2B regulation of growth, metabolism, and longevity in both insects and mammals
    Wei Song
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Cell Metab 11:427-37. 2010
    ..Here, we identified dSH2B as the Drosophila homolog of SH2B1. dSH2B bound to Chico and directly promoted insulin-like signaling...
  41. pmc Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling
    Lutz Kockel
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1000990. 2010
    ..These results illustrate how the Akt-TOR pathway dynamically adapts the routing of negative feedback in response to the activity load of its signaling circuit in vivo...
  42. pmc Lifespan extension by preserving proliferative homeostasis in Drosophila
    Benoit Biteau
    Department of Biology, University of Rochester, Rochester, New York, USA
    PLoS Genet 6:e1001159. 2010
    ....
  43. pmc dFOXO-independent effects of reduced insulin-like signaling in Drosophila
    Cathy Slack
    Institute of Healthy Ageing and GEE, University College London, Gower Street, London, UK
    Aging Cell 10:735-48. 2011
    ....
  44. pmc Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan
    Rochele Yamamoto
    Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Aging Cell 10:729-32. 2011
    ..Here, we conduct genetic epistasis analysis to determine whether foxo is required for chico mutants (insulin receptor substrate) to reduce age-specific mortality and thus extend lifespan...
  45. pmc Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway
    Na Hyun Choi
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 108:18702-7. 2011
    ..These results suggest that ISCs can indirectly sense changes in nutrient and insulin levels through contact with their daughters and reveal a mechanism that could link physiological changes in tissue growth to stem cell proliferation...
  46. pmc Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
    Timo Glatter
    Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland
    Mol Syst Biol 7:547. 2011
    ..Subsequent genetic studies in flies suggest a role for dTTT in controlling cell growth via a dTORC1- and dTORC2-dependent mechanism...
  47. doi Mutations in the Drosophila insulin receptor substrate, CHICO, impair olfactory associative learning
    Shintaro Naganos
    Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan
    Neurosci Res 73:49-55. 2012
    CHICO, the Drosophila homolog of vertebrate insulin receptor substrate (IRS), mediates insulin/insulin-like growth factor signaling (IIS), and reductions in chico severely disrupt cell growth and proliferation...
  48. ncbi Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms
    M Tatar
    Department of Ecology and Evolutionary Biology, Brown University, Box G W, Providence, RI 02912, USA
    Exp Gerontol 36:723-38. 2001
    ..elegans daf-2. We propose neuroendocrine control of reproductive diapause in D. melanogaster that includes phenotypic plasticity for rates of senescence...
  49. ncbi Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary
    David S Richard
    Department of Biology, Susquehanna University, Selinsgrove, PA 17870, USA
    J Insect Physiol 51:455-64. 2005
    ..However, female sterility of an insulin/IGF-like signaling mutant (chico(1)) of D...
  50. ncbi Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction
    Sergiy Libert
    Program in Cell and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, N820, Houston TX, 77030, United States
    Mol Immunol 45:810-7. 2008
    ..system in Drosophila carrying the longevity extending mutations puc (JNK signaling pathway, stress response) and chico (insulin signaling pathway), as well as animals subjected to dietary restriction (DR), which also extends lifespan...
  51. ncbi The carboxyl terminal extension of the Drosophila insulin receptor homologue binds IRS-1 and influences cell survival
    M Marin-Hincapie
    Department of Anatomy and Cell Biology, State University of New York, Health Science Center, Brooklyn, New York 11203, USA
    J Biol Chem 274:24987-94. 1999
    ..INR beta-Myc co-immunoprecipitated a phosphoprotein of 170 kDa identified as insulin receptor substrate-1 (IRS-1), whereas INR betaDelta did not, suggesting that the site of interaction was within the ..
  52. ncbi Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
    ..Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging...
  53. doi Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in Drosophila
    Cristina Pallares-Cartes
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Dev Cell 22:172-82. 2012
    ..Finally, this work sheds some light on the question of whether TORC1 activity is coupled to IIS in vivo...
  54. pmc Insulin signaling mediates sexual attractiveness in Drosophila
    Tsung Han Kuo
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Genet 8:e1002684. 2012
    ..These results suggest that the activity of conserved molecular regulators of longevity and reproductive output may manifest in different species as external characteristics that are perceived as honest indicators of fitness potential...
  55. pmc Fat body dSir2 regulates muscle mitochondrial physiology and energy homeostasis nonautonomously and mimics the autonomous functions of dSir2 in muscles
    Kushal K Banerjee
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
    Mol Cell Biol 33:252-64. 2013
    ..In summary, we show that fat body dSir2 is a master regulator of organismal energy homeostasis and is required for maintaining the metabolic regulatory network across tissues...
  56. pmc The drosophila T-box transcription factor midline functions within Insulin/Akt and c-Jun-N terminal kinase stress-reactive signaling pathways to regulate interommatial bristle formation and cell survival
    Q Brent Chen
    The Department of Biological Sciences, USM, USA
    Mech Dev 136:8-29. 2015
    ....
  57. pmc The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila
    Biao Wang
    Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA
    Cell Metab 7:434-44. 2008
    ..As disruption of insulin signaling also augmented TORC activity in adult flies, our results illustrate the importance of an insulin-regulated pathway that functions in the brain to maintain energy balance...
  58. pmc The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling
    Justin R DiAngelo
    The Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:20853-8. 2009
    ..These data suggest that communication between these two regulatory systems evolved as a means to divert energy in times of need from organismal growth to the acute requirement of combating infection...
  59. pmc Comparative transcriptional profiling identifies takeout as a gene that regulates life span
    Johannes Bauer
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Aging (Albany NY) 2:298-310. 2010
    ..behavior and juvenile hormone binding is also increased in four other life span extending conditions: Rpd3, Indy, chico and methuselah...
  60. pmc The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila
    Yuzuru Imai
    Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    PLoS Genet 6:e1001229. 2010
    ..These results suggest that PGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria and, furthermore, that PGAM5 acts between PINK1 and Parkin, or functions independently of Parkin downstream of PINK1...
  61. doi Molecular population genetics of the insulin/TOR signal transduction pathway: a network-level analysis in Drosophila melanogaster
    David Alvarez-Ponce
    Departament de Genetica, i Institut de Recerca de la Biodiversitat, Universitat de Barcelona, Barcelona, Spain
    Mol Biol Evol 29:123-32. 2012
    ..The detected polarity would be, therefore, intrinsic to the IT pathway architecture and function...
  62. pmc A cytogenetic analysis of chromosomal region 31 of Drosophila melanogaster
    N J Clegg
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genetics 134:221-30. 1993
    ..In addition, the cytological position of several mutations that interact with heterochromatin were more precisely defined...
  63. ncbi A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
    H K Sluss
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    Genes Dev 10:2745-58. 1996
    ..These data demonstrate that the DJNK signal transduction pathway mediates an immune response and morphogenesis in vivo...
  64. ncbi The latest in signal transduction, 1999. Specificity in Signal Transduction, Keystone, Colorado, USA, 9-14 April 1999
    E Spana
    Department of Genetics, Howrd Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Trends Genet 15:301-2. 1999
  65. ncbi The genetic control of organ growth: insights from Drosophila
    D Weinkove
    Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, 1066 CX, The Netherlands
    Curr Opin Genet Dev 10:75-80. 2000
    ..Furthermore, the role of Drosophila homologues to human tumour suppressor genes and oncogenes in imaginal disc growth has been investigated...
  66. ncbi Characterization of Drosophila insulin receptor substrate
    R M Poltilove
    Diabetes Branch, NIDDKD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:23346-54. 2000
    b>Insulin receptor substrate (IRS) proteins are phosphorylated by multiple tyrosine kinases, including the insulin receptor...
  67. pmc Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
    J C Clemens
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109 0606, USA
    Proc Natl Acad Sci U S A 97:6499-503. 2000
    ..We also show that Drosophila AKT (DAKT) activation depends on the insulin receptor substrate, CHICO (IRS1-4)...
  68. ncbi Genetic control of cell size
    H Stocker
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Opin Genet Dev 10:529-35. 2000
    ..Evidence is emerging for a signalling cascade conserved in evolution that links external nutrient sources to cell size...
  69. ncbi Lilliputian: an AF4/FMR2-related protein that controls cell identity and cell growth
    F Wittwer
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Development 128:791-800. 2001
    ..These results suggest that Lilli acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth...
  70. ncbi Longevity. Growing old together
    E Strauss
    Science 292:41-3. 2001
  71. ncbi Life span: getting the signal from the nervous system
    Catherine A Wolkow
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Trends Neurosci 25:212-6. 2002
    ..This review examines the evidence for nervous system control of longevity and discusses the implications for popular models for aging...
  72. ncbi Insulin receptor-mediated organ overgrowth in Drosophila is not restricted by body size
    Deborah C I Goberdhan
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
    Dev Genes Evol 212:196-202. 2002
    ..Given the evolutionarily conserved role of insulin receptor signalling in growth control, our data may also help to explain why this pathway is so frequently hyperactivated in mammalian tumours...
  73. ncbi A Drosophila melanogaster cell line (S2) facilitates post-genome functional analysis of receptors and ion channels
    Paula R Towers
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK
    Bioessays 24:1066-73. 2002
    ..In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines...
  74. ncbi Molecular genetics of aging in the fly: is this the end of the beginning?
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030 3301, USA
    Bioessays 25:134-41. 2003
    ....
  75. ncbi A small issue addressed
    Tina L Gumienny
    Department of Molecular Biology and Chemistry, Waksman Institute, Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ 08854 8020, USA
    Bioessays 25:305-8. 2003
    ..elegans, the TGFbeta-like pathway acts in the hypodermis to regulate cell size and consequently body size.1 This finding is an exciting step in discovering the molecular mechanisms that control cell and body size...
  76. ncbi Development. Wiring the brain with insulin
    Barry J Dickson
    Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria
    Science 300:440-1. 2003
  77. ncbi Axons guided by insulin receptor in Drosophila visual system
    Jianbo Song
    Brookdale Department for Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Science 300:502-5. 2003
    ..DInR functions as a guidance receptor for the adapter protein Dock/Nck. This function is independent of Chico, the Drosophila insulin receptor substrate (IRS) homolog.
  78. ncbi Genetics of aging in the fruit fly, Drosophila melanogaster
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3301, USA
    Annu Rev Genet 37:329-48. 2003
    ....
  79. ncbi Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster
    A J Hulbert
    Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
    Exp Gerontol 39:1137-43. 2004
    ..Thus, individual variation in lifespan in wild-type flies, and life extension by dietary-restriction and reduced insulin/IGF-1 signalling is not attributable to differences in metabolic rate...
  80. ncbi DNA methyltransferase gene dDnmt2 and longevity of Drosophila
    Meng Jau Lin
    Institute of Molecular Medicine, National Taiwan University, Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, Republic of China
    J Biol Chem 280:861-4. 2005
    ..The study links the Drosophila DNA methylation program with the small heatshock proteins and longevity/aging and has interesting implication on the eukaryotic DNA methylation programs in general...
  81. ncbi Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog
    Satomi Takeo
    Department of Biology, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
    Dev Biol 284:204-18. 2005
    ..These findings support the recently proposed model that secreted glypicans have opposing and/or distinct effects on morphogen signaling from the membrane-tethered forms...
  82. ncbi Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
    Thomas Flatt
    Division of Biology and Medicine, Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA
    Bioessays 27:999-1010. 2005
    ..In particular, we illustrate the role of JH as a key mediator of life history trade-offs...
  83. pmc Drosophila lacking microRNA miR-278 are defective in energy homeostasis
    Aurelio A Teleman
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 20:417-22. 2006
    ..We provide evidence that miR-278 mutants are insulin resistant and that miR-278 acts through regulation of the expanded transcript...
  84. ncbi Age-independent synaptogenesis by phosphoinositide 3 kinase
    Alfonso Martín-Peña
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 26:10199-208. 2006
    ..Thus, we propose that PI3K stimulation can be applied to prevent or delay synapse loss in normal aging and in neurological disorders...
  85. pmc Contribution of growth and cell cycle checkpoints to radiation survival in Drosophila
    Burnley Jaklevic
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
    Genetics 174:1963-72. 2006
    ..or onset of pupariation) or inhibition of growth factor signaling and downstream targets (by mutations in cdk4, chico, or dmyc) reduced the radiation survival of larvae...
  86. pmc Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy
    Halyna R Shcherbata
    Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
    EMBO J 26:481-93. 2007
    ..Importantly, we now report that Dg interacts with insulin receptor and Nck/Dock SH2/SH3-adaptor molecule in photoreceptor path-finding. This is the first demonstration of a genetic interaction between Dg and InR...
  87. pmc Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila
    Oliver Bell
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse, Basel, Switzerland
    EMBO J 26:4974-84. 2007
    ..Thus di- and trimethylation of H3K36 have opposite effects on H4K16 acetylation, which we propose enable dynamic changes in chromatin compaction during transcript elongation...
  88. pmc Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila
    Sudeshna Dutta
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    Curr Biol 18:1466-75. 2008
    ..Although the Warts (Wts) tumor suppressor is a critical regulator of tissue growth in animals, it is not clear how this signaling pathway controls cell growth...
  89. pmc Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila
    Kanyan Xu
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 8:289-300. 2008
    ..We propose that the input of neuronal clocks and clocks in metabolic tissues is coordinated to provide effective energy homeostasis...
  90. pmc Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila
    Fabio Demontis
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 136:983-93. 2009
    ..Thus, maximal dMyc transcriptional activity depends on InR to control muscle mass, which in turn induces a systemic behavioral response to allocate body size and proportions...
  91. pmc Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz
    Julie Hull-Thompson
    Department of Biology, University of Rochester, Rochester, New York, United States of America
    PLoS Genet 5:e1000460. 2009
    ..The JNK pathway and Lipocalins are structurally and functionally conserved, suggesting that similar interactions represent an evolutionarily conserved system for the control of metabolic homeostasis...
  92. doi FOXO-dependent regulation of innate immune homeostasis
    Thomas Becker
    Development, Genetics and Molecular Physiology Unit, LIMES Institute, University of Bonn, Carl Troll Strasse 31, D 53115 Bonn, Germany
    Nature 463:369-73. 2010
    ..The sparse production of AMPs in epithelial tissues in response to FOXO may help modulating the defence reaction without harming the host tissues, in particular when animals are suffering from energy shortage or stress...
  93. pmc Studies on the rate and site-specificity of P element transposition
    C A Berg
    Howard Hughes Medical Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Genetics 127:515-24. 1991
    ..During the course of these experiments, Y-linked insertions expressing rosy+ were recovered, suggesting that marked P elements can sometimes insert and function at heterochromatic sites...
  94. pmc A second maternally expressed Drosophila gene encodes a putative RNA helicase of the "DEAD box" family
    T de Valoir
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251
    Proc Natl Acad Sci U S A 88:2113-7. 1991
    ..A search for mutations in the ME31B gene has established that the P element which causes the female-sterile mutation flipper lies in the 3' flank of the ME31B gene.
  95. ncbi Perspectives: cell biology. All creatures great and small
    S J Leevers
    Ludwig Institute for Cancer Research, London, UK
    Science 285:2082-3. 1999
  96. ncbi The beauty of small flies
    C F Lehner
    Nat Cell Biol 1:E129-30. 1999
  97. ncbi The Cold Spring Harbor Laboratory meeting on tyrosine phosphorylation and cell signaling. Cold Spring Harbor, NY, USA, May 12-16, 1999
    M F Roussel
    Department of Tumor Cell Biology, Danny Thomas Research Tower, D5006C, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Biochim Biophys Acta 1470:R17-20. 2000
  98. ncbi Do growth and cell division rates determine cell size in multicellular organisms?
    C M Coelho
    Ludwig Institute for Cancer Research, London W1P 8BT, UK
    J Cell Sci 113:2927-34. 2000
    ..These interactions may provide a means of coordinating growth and cell division, such that cells divide only when they are above a minimum size...
  99. ncbi Mechanisms of size control
    C J Potter
    Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, Connecticut 06536 0812, USA
    Curr Opin Genet Dev 11:279-86. 2001
    ..The mechanisms of organ size control could also be critical targets for evolutionary events or disease processes such as tumorigenesis...
  100. ncbi The coupling of cell growth to the cell cycle
    N Tapon
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Curr Opin Cell Biol 13:731-7. 2001
    ..This work has revealed interesting and unexpected relationships between mechanisms that regulate growth and the cell cycle machinery...
  101. ncbi Insulin-related peptides and their conserved signal transduction pathway
    Ilse Claeys
    Laboratory for Developmental Physiology and Molecular Biology, K U, Leuven, Belgium
    Peptides 23:807-16. 2002
    ....

Research Grants9

  1. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2010
    ..Flies with ubiquitous, constitutive mutations at the insulin-like receptor (InR) and insulin receptor substrate (chico) retard demographic and functional aging, Recently, dFOXO of D...
  2. CSF-1 RECEPTOR SIGNALLING AND G1 PROGRESSION
    Martine Roussel; Fiscal Year: 2001
    ..The identification of novel effector molecules should enable definition of regulatory networks that govern events late in G1 phase, including the commitment to enter S phase. ..
  3. AGING AND NEURODEGENERATIVE DISEASES
    Cynthia Kenyon; Fiscal Year: 2006
    ....
  4. Nucleotide polymorphisms responsible for expression variation in Drosophila
    Sergey Nuzhdin; Fiscal Year: 2009
    ..These studies will contribute to building a pathway-minded description of complex character variation. They will shed light on the genetic architecture of transcript level variation in nature. ..
  5. QUANTITATIVE TRAIT LOCI RELATED TO DROSOPHILA SPECIATION
    Sergey Nuzhdin; Fiscal Year: 2004
    ..This comprehensive assessment of the genetics of several traits will further our understanding of the genetics of speciation. ..
  6. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2007
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span [unreadable] [unreadable]..
  7. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2010
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  8. MOLECULAR ANALYSIS OF TRANSCRIPTIONAL ADAPTORS
    Leonard Guarente; Fiscal Year: 2001
    ..Finally, a possible link between this coactivator and TBP will be investigated genetically and biochemically. ..
  9. LONGEVITY/CANDIDATE GENE POLYMORPHISMS IN DROSOPHILA
    Marc Tatar; Fiscal Year: 2003
    ..The genotype-phenotype associations detected with this design will be of broad significance to the problem of genetic variation for longevity in general populations. ..

Patents1

  1. In vivo insect model system for type-2 diabetes
    Patent Number: WO0078940-A1; Date:2000-12-28