cas

Summary

Gene Symbol: cas
Description: castor
Alias: CG2102, Cas, Dmel\CG2102, l(3)j1C2, l(3)neo33, ming, CG2102 gene product from transcript CG2102-RC, CG2102-PA, CG2102-PC, cas-PA, cas-PC
Species: fruit fly

Top Publications

  1. ncbi Programmed transformations in neuroblast gene expression during Drosophila CNS lineage development
    T Brody
    Neurogenetics Unit, Laboratory of Neurochemistry, NINDS, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Dev Biol 226:34-44. 2000
  2. ncbi Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development
    Mark Clements
    Department of Pathology, Washington University, Saint Louis, Missouri 63110, USA
    Dev Dyn 226:67-81. 2003
  3. ncbi Regulation of neuroblast competence in Drosophila
    Bret J Pearson
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
    Nature 425:624-8. 2003
  4. ncbi Regulation of temporal identity transitions in Drosophila neuroblasts
    Ruth Grosskortenhaus
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
    Dev Cell 8:193-202. 2005
  5. ncbi seven-up Controls switching of transcription factors that specify temporal identities of Drosophila neuroblasts
    Makoto I Kanai
    Division of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Dev Cell 8:203-13. 2005
  6. ncbi Regulation of post-embryonic neuroblasts by Drosophila Grainyhead
    Mara S Almeida
    Department of Anatomy, University of Cambridge, Downing Street, CA CB2 3DY, UK
    Mech Dev 122:1282-93. 2005
  7. pmc Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window
    Michael D Cleary
    University of Oregon Department of Neuroscience, Howard Hughes Medical Institute, Eugene, Oregon 97403, USA
    Genes Dev 20:429-34. 2006
  8. pmc Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage
    Ruth Grosskortenhaus
    Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Genes Dev 20:2618-27. 2006
  9. ncbi The Drosophila castor gene is involved in postembryonic brain development
    R Hitier
    D E P S N Institut de Neurobiologie Alfred Fessard, C N R S, 1 Avenue de la Terrasse, 91190 Gif Yvette, France
    Mech Dev 103:3-11. 2001
  10. pmc The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis
    Shu Wang
    Wistar Institute, Room 358, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:19873-8. 2007

Scientific Experts

  • Angelika Stollewerk
  • Ann E Rougvie
  • Jermaine Ross
  • Thomas Brody
  • Akihiko Nakajima
  • Alexander Kuzin
  • Bradley W Jones
  • Chris Doe
  • Weimin Zhong
  • Amy E Pasquinelli
  • B Hartmann
  • Y Bellaiche
  • Magnus Baumgardt
  • Stefan Thor
  • Jonathan Benito-Sipos
  • María Losada-Pérez
  • Daniel Karlsson
  • Khoa D Tran
  • Carina Ulvklo
  • Laura Torroja
  • Hugo Gabilondo
  • Ruth Grosskortenhaus
  • Ruth M Beckervordersandforth
  • Michael D Cleary
  • Evanthia Zacharioudaki
  • Brian W Busser
  • Sen Lin Lai
  • Qing Ma
  • Takumi Suzuki
  • Deirdre C Tatomer
  • Yu Chiuan Chang
  • Phing Chian Chai
  • Naoyuki Fuse
  • Man Sun Kim
  • Johnny J Touma
  • Joseph R Fontana
  • Chih Fei Kao
  • Isabel Molina
  • Minoree Kohwi
  • Helen J Hwang
  • Meridith Lorbeck
  • Sarah J Bray
  • Bret J Pearson
  • Ju Hyun Ahn
  • Atsushi Kitajima
  • C Stivers
  • Sang Hee Kim
  • Fernando J Diaz-Benjumea
  • Sang Hak Jeon
  • Stein Aerts
  • Miriam R Kantorovitz
  • Ki Seok Park
  • Takako Isshiki
  • W F Odenwald
  • Takuya Tsuji
  • Christof Rickert
  • Benjamin Altenhein
  • Gerhard M Technau
  • Christian M von Hilchen
  • Cédric Maurange
  • Shu Wang
  • Fumio Matsuzaki
  • K Koizumi
  • Mara S Almeida
  • Makoto I Kanai
  • Ward F Odenwald
  • Benjamin E Housden
  • Christos Delidakis
  • Mark Clements
  • Robert Stojnic
  • George Garinis
  • Allison L Abbott
  • Karin Dumstrei
  • Alan M Michelson
  • Guokai Chen
  • Jun Zhu
  • Yanqin Yang
  • Yongshun Lin
  • ERIKA L MATUNIS
  • Jay Uhler
  • Yalda Sedaghat
  • Guoyan Zhao
  • Tanja Novotny
  • Kaitlin P Curry
  • Makoto Sato
  • William F Marzluff
  • Alison M Witkowski
  • Robert J Duronio
  • Matthew Wawersik
  • Lindsay F Rizzardi

Detail Information

Publications85

  1. ncbi Programmed transformations in neuroblast gene expression during Drosophila CNS lineage development
    T Brody
    Neurogenetics Unit, Laboratory of Neurochemistry, NINDS, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Dev Biol 226:34-44. 2000
    ..of four proteins, Hunchback (Hb), Pou-homeodomain proteins 1 and 2 (referred to collectively as Pdm), and Castor (Cas), identifies a transcription factor network regulating the temporal development of all ganglia...
  2. ncbi Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development
    Mark Clements
    Department of Pathology, Washington University, Saint Louis, Missouri 63110, USA
    Dev Dyn 226:67-81. 2003
    ..Similarly, dNAB overexpression in the eye causes eyes to be very small with few ommatidia. These dramatic eye-specific phenotypes will prove useful for enhancer/suppressor screens to identify dnab-interacting genes...
  3. ncbi Regulation of neuroblast competence in Drosophila
    Bret J Pearson
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
    Nature 425:624-8. 2003
    ..These results match those observed in vertebrate systems, and establish Drosophila neuroblasts as a model system for the molecular genetic analysis of neural progenitor competence and plasticity...
  4. ncbi Regulation of temporal identity transitions in Drosophila neuroblasts
    Ruth Grosskortenhaus
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
    Dev Cell 8:193-202. 2005
    ..We conclude that two distinct "timers" regulate neuroblast gene expression: a hunchback --> Kruppel timer requiring cytokinesis, and a Kruppel --> pdm1 --> castor timer which is cell cycle independent...
  5. ncbi seven-up Controls switching of transcription factors that specify temporal identities of Drosophila neuroblasts
    Makoto I Kanai
    Division of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Dev Cell 8:203-13. 2005
    ..Lineage analysis provides evidence that svp is required to switch off HB at the proper time. Thus, svp modifies the self-renewal stem cell program to allow chronological change of cell fates, thereby generating neuronal diversity...
  6. ncbi Regulation of post-embryonic neuroblasts by Drosophila Grainyhead
    Mara S Almeida
    Department of Anatomy, University of Cambridge, Downing Street, CA CB2 3DY, UK
    Mech Dev 122:1282-93. 2005
    ..Thus one way Grh could regulate pNBs is through expression of E-cadherin, a protein that is thought to mediate interactions with the glial niche...
  7. pmc Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window
    Michael D Cleary
    University of Oregon Department of Neuroscience, Howard Hughes Medical Institute, Eugene, Oregon 97403, USA
    Genes Dev 20:429-34. 2006
    ..Our work raises the possibility that multiple competence windows may allow the same factors to generate different cell types within the same lineage...
  8. pmc Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage
    Ruth Grosskortenhaus
    Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Genes Dev 20:2618-27. 2006
    ..Embryonic neuroblasts sequentially express Hunchback, Krüppel, Pdm1/Pdm2 (Pdm), and Castor (Cas) transcription factors...
  9. ncbi The Drosophila castor gene is involved in postembryonic brain development
    R Hitier
    D E P S N Institut de Neurobiologie Alfred Fessard, C N R S, 1 Avenue de la Terrasse, 91190 Gif Yvette, France
    Mech Dev 103:3-11. 2001
    castor (cas) encodes a zink finger protein expressed in a subset of Drosophila embryonic neuroglioblasts where it controls neuronal differentiation...
  10. pmc The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis
    Shu Wang
    Wistar Institute, Room 358, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:19873-8. 2007
    ..This ontogenic-molecular concordance suggests that a rudimentary brain endocrine axis was present in the common ancestor of humans and flies, where it orchestrated the islet-like endocrine functions of insulin and glucagon biology...
  11. doi Temporal transcription factors and their targets schedule the end of neural proliferation in Drosophila
    Cédric Maurange
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Cell 133:891-902. 2008
    ..These studies identify the timing mechanism ending CNS proliferation and reveal how aging progenitors transduce bursts of transcription factors into long-lasting changes in cell proliferation and cell identity...
  12. pmc Pdm and Castor close successive temporal identity windows in the NB3-1 lineage
    Khoa D Tran
    Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
    Development 135:3491-9. 2008
    ..Our results provide a new neuroblast lineage for investigating temporal identity and reveal the importance of Pdm and Cas as timing factors that close temporal identity windows.
  13. doi Neuronal subtype specification within a lineage by opposing temporal feed-forward loops
    Magnus Baumgardt
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping SE 581 85, Sweden
    Cell 139:969-82. 2009
    ..This mechanism of temporal and "subtemporal" genes acting in opposing feed-forward loops may be used by many stem cell lineages to generate diversity...
  14. pmc Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues
    Daniel Karlsson
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    PLoS Biol 8:e1000368. 2010
    ..This study reveals a surprisingly restricted, yet multifaceted, function of both anteroposterior and temporal cues with respect to lineage control and cell fate specification...
  15. pmc Robustness under functional constraint: the genetic network for temporal expression in Drosophila neurogenesis
    Akihiko Nakajima
    Department of Basic Science, University of Tokyo, Komaba, Tokyo, Japan
    PLoS Comput Biol 6:e1000760. 2010
    ..This study suggests that the Drosophila network for sequential expression has evolved to generate the robust temporal expression for neuronal specification...
  16. pmc Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS
    R Kambadur
    The Neurogenetics Unit, Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892 USA
    Genes Dev 12:246-60. 1998
    ..We report all known Drosophila POU genes require castor (cas) for correct CNS expression...
  17. doi Drosophila castor is regulated negatively by the Ubx and abdA genes, but positively by the AbdB gene
    Ju Hyun Ahn
    Department of Biology Education, Seoul National University, Seoul, Korea
    Int J Dev Biol 54:1251-8. 2010
    ..Homeotic genes are expressed over long periods of time and confer identity to the different segments. castor (cas) is one of the genes which are expressed in neuroblasts along the VNC...
  18. pmc Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation
    Joseph R Fontana
    Department of Biochemistry and Biophysics, Program in Molecular Biology and Biotechnology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Dev Biol 372:131-42. 2012
    ..This indicates a novel function for castor in regulating neuropeptide gene expression...
  19. ncbi New neuroblast markers and the origin of the aCC/pCC neurons in the Drosophila central nervous system
    J Broadus
    Neuroscience Program, Howard Hughes Medical Institute, University of Illinois, Urbana 61801, USA
    Mech Dev 53:393-402. 1995
    ..These results are supported by DiI cell lineage analysis of neuroblasts identified in vivo...
  20. ncbi castor encodes a novel zinc finger protein required for the development of a subset of CNS neurons in Drosophila
    D M Mellerick
    Neurogenetics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Neuron 9:789-803. 1992
    ....
  21. ncbi Neuronal cell fate specification in Drosophila
    Y N Jan
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco 94143 0724
    Curr Opin Neurobiol 4:8-13. 1994
    ..Selective expression of certain neuronal-type selector genes further specifies the type of neuron(s) that a neural precursor will produce...
  22. ncbi ming is expressed in neuroblast sublineages and regulates gene expression in the Drosophila central nervous system
    X Cui
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Development 116:943-52. 1992
    ..We used an enhancer trap screen to identify the ming gene, which is transiently expressed in a subset of neuroblasts at reproducible points in their cell lineage (i.e...
  23. ncbi Hunchback is required for the specification of the early sublineage of neuroblast 7-3 in the Drosophila central nervous system
    Tanja Novotny
    Institut fur Genetik, Universitat Mainz, Saarstrasse 21, D 55122 Mainz, Germany
    Development 129:1027-36. 2002
    ....
  24. ncbi Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny
    T Isshiki
    Institute of Neuroscience Institute of Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA
    Cell 106:511-21. 2001
    ..We propose that Hunchback and Krüppel control early-born temporal identity in neuroblast cell lineages...
  25. pmc Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions
    Deirdre C Tatomer
    a Department of Biology University of North Carolina Chapel Hill, NC USA
    Nucleus 5:613-25. 2014
    ..This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions. ..
  26. ncbi Intrinsic and extrinsic regulators of developmental timing: from miRNAs to nutritional cues
    Ann E Rougvie
    University of Minnesota, Department of Genetics, Cell Biology and Development, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Development 132:3787-98. 2005
    ..Particular attention is given to the roles of miRNAs in developmental timing and to the emerging mechanisms that link developmental programs to nutritional cues...
  27. pmc The Jak-STAT target Chinmo prevents sex transformation of adult stem cells in the Drosophila testis niche
    Qing Ma
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 31:474-86. 2014
    ..Our work indicates that sex maintenance occurs in adult somatic stem cells and that this highly conserved process is governed by effectors of niche signals. PAPERCLIP: ..
  28. pmc cis-regulatory analysis of the Drosophila pdm locus reveals a diversity of neural enhancers
    Jermaine Ross
    The Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, MD, USA
    BMC Genomics 16:700. 2015
    ..The focus of this study is the discovery and characterization of cis-regulatory DNA that governs their expression...
  29. doi Klumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage
    María Losada-Pérez
    Departamento de Biologia, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Development 140:2181-9. 2013
    ..Similar to WT1, klu seems to have either self-renewal or differentiation-promoting functions, depending on the developmental context...
  30. ncbi Evolution of early development of the nervous system: a comparison between arthropods
    Angelika Stollewerk
    Department of Zoology, University of Cambridge, Cambridge, UK
    Bioessays 27:874-83. 2005
    ..We hypothesize that an evolutionary trend towards reduced cell numbers and possibly rapid embryogenesis in insects has culminated in the appearance of stereotyped neuroblast lineages...
  31. pmc Genes implicated in stem cell identity and temporal programme are directly targeted by Notch in neuroblast tumours
    Evanthia Zacharioudaki
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK Institute of Molecular Biology and Biotechnology, FORTH Hellas, Heraklion, Crete 70013, Greece Department of Biology, University of Crete, Heraklion, Greece GR71409
    Development 143:219-31. 2016
    ..Altogether, the results suggest that Notch induces neuroblast tumours by directly promoting the expression of genes that contribute to stem cell identity and by reprogramming the expression of factors that could regulate maturity...
  32. pmc An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis
    Brian W Busser
    Systems Biology Center, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, United States of America
    PLoS ONE 10:e0141066. 2015
    ..Collectively, these results show that orthologous gene expression signatures can be used to identify conserved cardiogenic pathways. ..
  33. pmc Transient nuclear Prospero induces neural progenitor quiescence
    Sen Lin Lai
    Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States
    elife 3:. 2014
    ..We propose that Prospero levels distinguish three progenitor fates: absent for self-renewal, low for quiescence, and high for differentiation. ..
  34. doi Neurogenesis and neuronal circuit formation in the Drosophila visual center
    Takumi Suzuki
    Laboratory of Developmental Neurobiology, Brain Liver Interface Medicine Research Center, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8640, Japan
    Dev Growth Differ 56:491-8. 2014
    ..Here, we review recent investigations into the development of the medulla and discuss the mechanisms that establish functional neuronal circuits. ..
  35. ncbi Nerfin-1 and -2, novel Drosophila Zn-finger transcription factor genes expressed in the developing nervous system
    C Stivers
    The Neurogenetics Unit, Laboratory of Neurochemistry, NINDS, NIH, Bethesda, MD 20892, USA
    Mech Dev 97:205-10. 2000
    ..Possessing a conserved putative DNA-binding domain, the predicted Nerfin-1 and -2 proteins belong to a subfamily of Zn-finger transcription factors with cognates identified in nematode, mouse and man...
  36. pmc Hedgehog signaling acts with the temporal cascade to promote neuroblast cell cycle exit
    Phing Chian Chai
    Temasek Life Sciences Laboratory, National University of Singapore, Singapore
    PLoS Biol 11:e1001494. 2013
    ..Interestingly, hh is likely a target of Castor. Hence, Hh signaling provides a link between the temporal series and the asymmetric division machinery in scheduling the end of neurogenesis...
  37. pmc Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in Drosophila melanogaster
    Man Sun Kim
    Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Republic of Korea
    BMC Syst Biol 6:31. 2012
    ..To overcome this limitation, we proposed the concept of a "spatiotemporal network motif," a spatiotemporal sequence of network motifs of sub-networks which are active only at specific time points and body parts...
  38. ncbi The CNS midline cells and spitz class genes are required for proper patterning of Drosophila ventral neuroectoderm
    C M Lee
    Department of Chemistry, Konkuk University, Seoul, Korea
    Int J Dev Biol 43:305-15. 1999
    ..This study suggests that the CNS midline cells and spitz class genes are necessary for proper patterning of the ventral neuroectoderm along the dorsal-ventral axis...
  39. doi Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development
    Atsushi Kitajima
    Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Dev Biol 347:9-23. 2010
    ....
  40. doi Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene
    María Losada-Pérez
    Departamento de Biologia, Universidad Autonoma de Madrid, Cantoblanco, E 28049 Madrid, Spain
    Mech Dev 127:458-71. 2010
    ..Furthermore, these results imply that the activation of a particular terminal differentiation gene in temporally unrestricted...
  41. pmc The pipsqueak-domain proteins Distal antenna and Distal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity
    Minoree Kohwi
    Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
    Development 138:1727-35. 2011
    ..sequentially express the transcription factors Hunchback (Hb), Krüppel (Kr), Pdm1/Pdm2 (Pdm) and Castor (Cas)...
  42. pmc Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism
    Meridith Lorbeck
    Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e18412. 2011
    ....
  43. pmc Serial specification of diverse neuroblast identities from a neurogenic placode by Notch and Egfr signaling
    Helen J Hwang
    Biomedical Sciences Graduate Program, University of California San Francisco, CA 94143, USA
    Development 138:2883-93. 2011
    ..We discuss the surprising parallels between the serial specification of neural fates from this neurogenic placode and the fly retina...
  44. doi Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development
    Jonathan Benito-Sipos
    Departamento de Biologia, Universidad Autonoma de Madrid, Madrid, Spain
    Development 138:5311-20. 2011
    ..This is controlled by a temporal cascade of Hb→Kr→Pdm→Cas→Grh, which acts to dictate distinct competence windows sequentially...
  45. pmc Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers
    Thomas Brody
    Neural Cell Fate Determinants Section, NINDS, NIH, Bethesda, Maryland 20892, USA
    Dev Dyn 241:169-89. 2012
    ..Currently, there is no systematic approach for enhancer discovery and analysis that takes full-advantage of the sequence information within enhancer CSCs...
  46. doi Drosophila Polycomb complexes restrict neuroblast competence to generate motoneurons
    Johnny J Touma
    School of Natural Sciences, University of California Merced, CA 95343, USA
    Development 139:657-66. 2012
    ..These findings support a model in which PRCs establish motoneuron-specific competence windows in neuroblasts that transition from motoneuron to interneuron production...
  47. doi Control of neuronal cell fate and number by integration of distinct daughter cell proliferation modes with temporal progression
    Carina Ulvklo
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Development 139:678-89. 2012
    ..This demonstrates that different daughter cell proliferation modes can be integrated with temporal competence changes, and suggests a novel mechanism for coordinately controlling neuronal subtype numbers...
  48. pmc Hierarchical deployment of factors regulating temporal fate in a diverse neuronal lineage of the Drosophila central brain
    Chih Fei Kao
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 73:677-84. 2012
    ..complete lineage sequence to examine the role of known temporal fating factors, including Chinmo and the Hb/Kr/Pdm/Cas transcriptional cascade, within this diverse central brain lineage...
  49. pmc The cis-regulatory dynamics of the Drosophila CNS determinant castor are controlled by multiple sub-pattern enhancers
    Alexander Kuzin
    Neural Cell Fate Determinants Section, NINDS, NIH 9000 Rockville Pike, Bethesda, MD 20892, USA
    Gene Expr Patterns 12:261-72. 2012
    ..cells or neuroblasts (NBs) is marked by the expression of a zinc-finger transcription factor (TF) gene, castor (cas)...
  50. pmc Castor is required for Hedgehog-dependent cell-fate specification and follicle stem cell maintenance in Drosophila oogenesis
    Yu Chiuan Chang
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 110:E1734-42. 2013
    ..Here we identify Castor (Cas) as a nuclear protein that is expressed in FSCs and early follicle cell precursors and then is restricted to ..
  51. ncbi Pollux, a novel Drosophila adhesion molecule, belongs to a family of proteins expressed in plants, yeast, nematodes, and man
    S D Zhang
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Genes Dev 10:1108-19. 1996
    ..Plx also contains a motor neuron-selective adhesive site, multiple proteoglycan-binding motifs, and a leucine zipper: all suggest possible associations with additional components of the adhesion complex...
  52. pmc The Triplo-lethal locus of Drosophila: reexamination of mutants and discovery of a second-site suppressor
    D R Dorer
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541, USA
    Genetics 141:1037-42. 1995
    ..Su(Tpl) mutations suppress the lethality associated with three copies of the Triplo-lethal locus and are recessive lethal. We have mapped Su(Tpl) to the approximate map position 3-46.5, within the cytological region 76B-76D...
  53. ncbi Neural fate specification in Drosophila
    F Jimenez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma, Madrid, Spain
    Curr Opin Genet Dev 3:626-32. 1993
    ..These comprise the initial selection of neural precursors from the ectoderm, the implementation of a basic neural fate common to all precursors and the concomitant endowment of each precursor and its progeny with specific fates...
  54. doi A genetic cascade involving klumpfuss, nab and castor specifies the abdominal leucokinergic neurons in the Drosophila CNS
    Jonathan Benito-Sipos
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma C S I C, Madrid, Spain
    Development 137:3327-36. 2010
    ..We also show that the products of the genes klumpfuss, nab and castor play important roles in their specification via a genetic cascade...
  55. pmc Codon reiteration and the evolution of proteins
    H Green
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 91:4298-302. 1994
    ..The preferential generation of such reiterants requires that DNA strand-specific signals predispose to reiteration and thus to the extension of coding regions...
  56. ncbi The role of the cell cycle and cytokinesis in regulating neuroblast sublineage gene expression in the Drosophila CNS
    X Cui
    Howard Hughes Medical Institute, Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    Development 121:3233-43. 1995
    ..Here we show that four genes (ming, even-skipped, unplugged and achaete) are expressed in specific neuroblast sublineages...
  57. ncbi CNS midline to mesoderm signaling in Drosophila
    L Zhou
    Program for Neuroscience and Behavior, University of Massachusetts at Amherst, 01003, USA
    Mech Dev 67:59-68. 1997
    ..Taken together, these data define a novel neuroectoderm to mesoderm signaling pathway and suggest that unique mesodermal cell types are specified by a combination of midline and segmental cues...
  58. pmc Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity
    Khoa D Tran
    Institute of Neuroscience, Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
    Development 137:1421-30. 2010
    ..We propose that Hunchback maintains early neuroblast competence by silencing a suite of late-expressed genes...
  59. ncbi A search for Drosophila neural precursor genes identifies ran
    K Koizumi
    The Neurogenetics Unit, Laboratory of Neurochemistry, NINDS, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Dev Genes Evol 211:67-75. 2001
    ..However, expression of the dominant-negative mutant ran in the developing eye/antenna disc did result in a severe adult eye phenotype marked by apoptosis of photoreceptor, cone and pigment cells...
  60. ncbi Cellular diversity in the developing nervous system: a temporal view from Drosophila
    Thomas Brody
    The Neurogenetics Unit, Laboratory of Neurochemistry, NINDS, NIH, Bethesda, MD, USA
    Development 129:3763-70. 2002
    ..states have so far been identified, characterized by the successive expression of Hb-->Kr-->Pdm-->Cas-->Gh in many, but not all, neuroblasts...
  61. ncbi Diversifying neural cells through order of birth and asymmetry of division
    Weimin Zhong
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Neuron 37:11-4. 2003
    ..Drosophila genes governing temporal cell fate determination and asymmetric cell divisions involving numb may represent evolutionarily conserved mechanisms for regulating cell fate diversification in the developing nervous system...
  62. ncbi Role of DE-cadherin in neuroblast proliferation, neural morphogenesis, and axon tract formation in Drosophila larval brain development
    Karin Dumstrei
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 23:3325-35. 2003
    ..We conclude that DE-cadherin plays a pivotal role in larval brain proliferation, brain cortex morphogenesis, and axon growth...
  63. ncbi Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions
    Naoyuki Fuse
    Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, Chuou ku, Kobe 650 0047, Japan
    Curr Biol 13:947-54. 2003
    ..Furthermore, the multiple equal cleavages of G beta mutant neuroblasts accompany neural defects; this finding suggests indispensable roles of eccentric division in assuring the stem cell properties of neuroblasts...
  64. ncbi Nk6, a novel Drosophila homeobox gene regulated by vnd
    Jay Uhler
    Department of Pathology, University of Michigan, Ann Arbor 48109, USA
    Mech Dev 116:105-16. 2002
    ..Conversely, vnd-overexpression leads to ectopic Nk6 expression in the brain. These findings further highlight the importance of interactions between Nk(x)-type genes in regulating their expression...
  65. ncbi Heterochronic genes
    Allison L Abbott
    Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Curr Biol 13:R824-5. 2003
  66. ncbi Transcriptional control of glial cell development in Drosophila
    Bradley W Jones
    Department of Biology, The University of Mississippi, 122 Shoemaker Hall, University, MS 38677, USA
    Dev Biol 278:265-73. 2005
    ....
  67. ncbi Changing fates on the road to neuronal diversity
    Ward F Odenwald
    Neural Cell Fate Determinants Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, MD 20892, USA
    Dev Cell 8:133-4. 2005
    ..Two new studies, in this issue of Developmental Cell, provide novel insights into the molecular details of how Drosophila NPCs transition from one offspring identity program to the next...
  68. ncbi The jing gene is required for embryonic brain development in Drosophila [corrected]
    Yalda Sedaghat
    Faculty of Medicine, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    Dev Genes Evol 212:277-87. 2002
    ..These results show that an important role for jing in the developing brain is the regulation of neuronal and glial differentiation and survival...
  69. ncbi The Sox-domain containing gene Dichaete/fish-hook acts in concert with vnd and ind to regulate cell fate in the Drosophila neuroectoderm
    Guoyan Zhao
    Program in Molecular Cell Biology, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Development 129:1165-74. 2002
    ....
  70. ncbi Temporal coordinates: the genes that fix cell fate with birth order
    W A Harris
    Department of Anatomy, Cambridge University, United Kingdom
    Dev Cell 1:313-4. 2001
    ..In analogy to spatial coordinate genes that specify neuroblasts by position, these sequentially expressed genes can be called "temporal coordinate genes."..
  71. ncbi Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system
    C Q Doe
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Development 116:855-63. 1992
    ..These results set the stage for investigating neuroblast specification and the mechanisms controlling neuroblast cell lineages...
  72. ncbi Neurobiology. Developing order
    R Livesey
    Nature 413:471, 473. 2001
  73. ncbi Expression, regulation and function of the homeobox gene empty spiracles in brain and ventral nerve cord development of Drosophila
    B Hartmann
    Institute of Zoology, University of Basel, Rheinsprung 9, 4051, Basel, Switzerland
    Mech Dev 90:143-53. 2000
    ..In the posterior brain and VNC ems is necessary for correct axonal pathfinding of specific interneurons. Rescue experiments indicate that the murine Emx2 gene can partially replace the fly ems gene in CNS development...
  74. ncbi Lineage diversity in the Drosophila nervous system
    Y Bellaiche
    Ecole Normale Superieure, UMR 8544, 46, rue d Ulm, 75230 Cedex 05, Paris, France
    Curr Opin Genet Dev 11:418-23. 2001
    ..The detailed descriptions of cellular lineages in the Drosophila nervous system have provided the foundations for an in-depth genetic analysis of the mechanisms that regulate fate decisions at every cell cycle...
  75. ncbi Chinmo and neuroblast temporal identity
    Chris Q Doe
    Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Cell 127:254-6. 2006
    ..In this issue, Zhu et al. (2006) identify the Chinmo protein as conferring temporal identity on the neural progeny of Drosophila neuroblasts, revealing appealing parallels with spatial patterning...
  76. ncbi Cycling through development in Drosophila and other metazoa
    S J Vidwans
    Department of Biochemistry and Biophysics, University of California at San Francisco, California 94143 0448, USA
    Nat Cell Biol 3:E35-9. 2001
    ..Here we present the various modes of cell-cycle regulation in metazoa and discuss their possible generation by a combination of universally conserved molecules and new regulatory circuits...
  77. ncbi Identity, origin, and migration of peripheral glial cells in the Drosophila embryo
    Christian M von Hilchen
    Institute of Genetics, University of Mainz, Saarstrasse 21, D 55122 Mainz, Germany
    Mech Dev 125:337-52. 2008
    ..By studying their lineages, we uncovered the origin of each of the peripheral glial cells and linked them to identified central and peripheral neural stem cells...
  78. doi Subtypes of glial cells in the Drosophila embryonic ventral nerve cord as related to lineage and gene expression
    Ruth M Beckervordersandforth
    Institute of Genetics, University of Mainz, Saarstrasse 21, D 55122 Mainz, Germany
    Mech Dev 125:542-57. 2008
    ..We demonstrate this by the analysis of a castor loss of function mutation, which affects the number and migration of specific glial cells...
  79. ncbi The CNS midline cells coordinate proper cell cycle progression and identity determination of the Drosophila ventral neuroectoderm
    J Chang
    Department of Chemistry, Konkuk University, Seoul, 143 701, Korea
    Dev Biol 227:307-23. 2000
    ..This study indicates that the CNS midline cells play important roles in the coordination of the proper cell cycle progression and the correct identity determination of the adjacent ventral neuroectoderm along the dorsoventral axis...
  80. doi Neuroblast entry into quiescence is regulated intrinsically by the combined action of spatial Hox proteins and temporal identity factors
    Takuya Tsuji
    Center for Frontier Research, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 135:3859-69. 2008
    ....
  81. pmc Integrating computational biology and forward genetics in Drosophila
    Stein Aerts
    Department of Molecular and Developmental Genetics, Laboratory of Neurogenetics, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    PLoS Genet 5:e1000351. 2009
    ..A systems genetics approach that combines the power of computational predictions with in vivo genetic screens strongly enhances the process of gene function and gene-gene association discovery...
  82. doi Ectopic Repo suppresses expression of castor gene in Drosophila central nervous system
    Ki Seok Park
    Department of Biology Education, Seoul National University, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 388:187-92. 2009
    ..One of the NB genes, castor (cas), is expressed in a subset of NBs and has never been identified in neurons and the peripheral nervous system; cas ..
  83. pmc Motif-blind, genome-wide discovery of cis-regulatory modules in Drosophila and mouse
    Miriam R Kantorovitz
    Department of Mathematics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Dev Cell 17:568-79. 2009
    ..Overall, 7/7 predictions were validated successfully in vivo, demonstrating the effectiveness of our approach for insect and mammalian genomes...
  84. ncbi Regulatory mutations of the Drosophila Sox gene Dichaete reveal new functions in embryonic brain and hindgut development
    N Sanchez-Soriano
    Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, United Kingdom
    Dev Biol 220:307-21. 2000
    ..Taken together, there are now four distinct in vivo functions described for Dichaete that can be used as models for context-dependent comparative studies of Sox function...
  85. ncbi Control of developmental timing by micrornas and their targets
    Amy E Pasquinelli
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Cell Dev Biol 18:495-513. 2002
    ..Instead of inventing new gene functions, even subtle changes in temporal expression of pre-existing control genes can result in speciation by altering the time at which they function...

Research Grants2

  1. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  2. Functional Analysis of Mouse Numb and Numblike in Neural Development
    Weimin Zhong; Fiscal Year: 2010
    ..Such knowledge may point to mechanisms that cause brain cells to revert to less differentiated states in brain tumors or degenerate in neurological disorders. ..