cac

Summary

Gene Symbol: cac
Description: cacophony
Alias: CAC, CG1522, CG15928, CG43368, Ca-alpha1A, Ca[[V]]2.1, Cac, Cac1, Dmca1A, Dmcalpha1A, Dmel\CG43368, Dmel_CG1522, Dmel_CG15928, EE171, H18, H47, L13, P18, alpha1A, cac1, dCac1, l(1)11Aa, l(1)13, l(1)L13, ldg, nbA, nonB, opm18, opm47, CG43368 gene product from transcript CG43368-RI, CG43368-PA, CG43368-PB, CG43368-PC, CG43368-PD, CG43368-PE, CG43368-PF, CG43368-PG, CG43368-PH, CG43368-PI, CG43368-PJ, CG43368-PL, CG43368-PM, CG43368-PN, CG43368-PO, CG43368-PP, cac-PA, cac-PB, cac-PC, cac-PD, cac-PE, cac-PF, cac-PG, cac-PH, cac-PI, cac-PJ, cac-PL, cac-PM, cac-PN, cac-PO, cac-PP, cacaphony, cacophany, calcium channel alpha1 subunit, type A, lamina-degeneration, lethal(1)11Aa, night blind A, nightblind, nightblind A, no-on-transient B
Species: fruit fly

Top Publications

  1. doi Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth
    Jeffrey S Dason
    Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Cell Sci 122:4109-21. 2009
  2. ncbi A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects
    L A Smith
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    J Neurosci 16:7868-79. 1996
  3. doi Naked dense bodies provoke depression
    Stefan Hallermann
    Carl Ludwig Institute of Physiology, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
    J Neurosci 30:14340-5. 2010
  4. ncbi A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity
    M J Palladino
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    Cell 102:437-49. 2000
  5. ncbi A temperature-sensitive paralytic mutant defines a primary synaptic calcium channel in Drosophila
    F Kawasaki
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 20:4885-9. 2000
  6. doi ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot
    Katarzyna Miskiewicz
    VIB, Department of Molecular and Developmental Genetics, B3000 Leuven, Belgium
    Neuron 72:776-88. 2011
  7. doi RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release
    Karen S Y Liu
    Department of Genetics, Institute for Biology, Free University Berlin, 14195 Berlin, Germany
    Science 334:1565-9. 2011
  8. pmc Courtship and visual defects of cacophony mutants reveal functional complexity of a calcium-channel alpha1 subunit in Drosophila
    L A Smith
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Genetics 149:1407-26. 1998
  9. pmc Maturation of active zone assembly by Drosophila Bruchpilot
    Wernher Fouquet
    Institute for Biology Genetics, Free University Berlin, Berlin, Germany
    J Cell Biol 186:129-45. 2009
  10. pmc Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila
    A A Peixoto
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Genetics 148:827-38. 1998

Research Grants

  1. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
  2. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007

Scientific Experts

  • Lyle Wiemerslage
  • J M Gleason
  • Jihye Lee
  • Malgorzata Lagisz
  • Stefanie Ryglewski
  • Hiroshi Kuromi
  • Jeffrey S Dason
  • G T Macleod
  • A A Peixoto
  • J C Hall
  • Bruce S Baker
  • Mark Stapleton
  • Richard R Copley
  • Mikio Furuse
  • G O Pflugfelder
  • David Shuker
  • Stephan J Sigrist
  • Fumiko Kawasaki
  • Carolin Wichmann
  • Wernher Fouquet
  • Robert J Kittel
  • LESLIE GRIFFITH
  • Graeme W Davis
  • C Andrew Frank
  • Sara Mertel
  • Richard W Ordway
  • Dion K Dickman
  • I Feng Peng
  • Manfred Heckmann
  • Martin Muller
  • Ethan R Graf
  • Andreas Schmid
  • Hugo J Bellen
  • Harald Depner
  • Stefan Hallermann
  • Patrik Verstreken
  • Peri T Kurshan
  • Thomas L Schwarz
  • Fu De Huang
  • Cindy V Ly
  • Ying Wu
  • Ashlyn M Spring
  • Shin Ichiro Terada
  • Haneui Bae
  • Chunlai Wu
  • Olivier Urwyler
  • Wen Hu
  • Xuejun Tian
  • Beiyan Zou
  • Jer Cherng Chang
  • Ben Jiwon Choi
  • Simon Lepicard
  • Long Li
  • Manuela Schmidt
  • John M Gillespie
  • Jian Kang Huang
  • Tobias M Rasse
  • Aaron DiAntonio
  • Guadalupe Astorga
  • Karen S Y Liu
  • Katarzyna Miskiewicz
  • Liam P Keegan
  • Kazuya Tsurudome
  • Elena Repnikova
  • Robert A Carrillo
  • Stefan Eimer
  • Angela Gallo
  • David Owald
  • Huaiyu Gu
  • Stefan W Hell
  • Jiamei Hou
  • A Ashleigh Long
  • Jason W Worrell
  • Eliana Romero
  • D Yamamoto
  • Chun Fang Wu
  • Kendal Broadie
  • Elvin Woodruff
  • Jingjun Li
  • R Felling
  • F Kawasaki
  • R W Ordway
  • Gang Qin
  • Vanessa M Ray
  • L A Smith
  • Ping Wang
  • J Troy Littleton
  • James Brindle
  • MARY A O'CONNELL
  • Zhuo Guan

Detail Information

Publications97

  1. doi Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth
    Jeffrey S Dason
    Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Cell Sci 122:4109-21. 2009
    ..Overall, Frq modulates Ca(2+) entry through a functional interaction with the alpha(1) voltage-gated Ca(2+)-channel subunit; this interaction regulates neurotransmission and nerve-terminal growth...
  2. ncbi A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects
    L A Smith
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    J Neurosci 16:7868-79. 1996
    ..Dmca1A maps to a chromosomal region implicated in, and is the likely candidate for, the gene involved in the generation of behavioral, physiological, and lethal phenotypes of the cacophony, nightblind-A, and lethal(1)L13 mutants.
  3. doi Naked dense bodies provoke depression
    Stefan Hallermann
    Carl Ludwig Institute of Physiology, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
    J Neurosci 30:14340-5. 2010
    ..Furthermore, rapid recovery following sustained release was slowed. Our results causally link, with intramolecular precision, the tethering of vesicles at the AZ cytomatrix to synaptic depression...
  4. ncbi A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity
    M J Palladino
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    Cell 102:437-49. 2000
    ..Surprisingly, dADAR mutants are not short-lived. Thus, A-to-I editing of pre-mRNAs in Drosophila acts predominantly through nervous system targets to affect adult nervous system function, integrity, and behavior...
  5. ncbi A temperature-sensitive paralytic mutant defines a primary synaptic calcium channel in Drosophila
    F Kawasaki
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 20:4885-9. 2000
    ..isolated a temperature-sensitive paralytic allele of the Drosophila calcium channel alpha1 subunit gene, cacophony (cac)...
  6. doi ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot
    Katarzyna Miskiewicz
    VIB, Department of Molecular and Developmental Genetics, B3000 Leuven, Belgium
    Neuron 72:776-88. 2011
    ..We propose a model where ELP3-dependent acetylation of Bruchpilot at synapses regulates the structure of individual presynaptic densities and neurotransmitter release efficiency...
  7. doi RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release
    Karen S Y Liu
    Department of Genetics, Institute for Biology, Free University Berlin, 14195 Berlin, Germany
    Science 334:1565-9. 2011
    ..Our data identify RBP family proteins as prime effectors of the AZ scaffold that are essential for the coupling of SVs, Ca(2+) channels, and the SV fusion machinery...
  8. pmc Courtship and visual defects of cacophony mutants reveal functional complexity of a calcium-channel alpha1 subunit in Drosophila
    L A Smith
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Genetics 149:1407-26. 1998
    ..that the Drosophila Dmca1A calcium-channel alpha1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and ..
  9. pmc Maturation of active zone assembly by Drosophila Bruchpilot
    Wernher Fouquet
    Institute for Biology Genetics, Free University Berlin, Berlin, Germany
    J Cell Biol 186:129-45. 2009
    ..BRP seems responsible for effectively clustering Ca(2+) channels beneath the T-bar density late in a protracted AZ formation process, potentially through a direct molecular interaction with intracellular Ca(2+) channel domains...
  10. pmc Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila
    A A Peixoto
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Genetics 148:827-38. 1998
    cacophony (cac), a mutation affecting the courtship song in Drosophila melanogaster, is revealed to cause temperature-sensitive (TS) abnormalities...
  11. doi Delayed synaptic transmission in Drosophila cacophonynull embryos
    Jiamei Hou
    Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    J Neurophysiol 100:2833-42. 2008
    Ca(2+) influx through the Drosophila N-type Ca(2+) channel, encoded by cacophony (cac), triggers fast synaptic transmission. We now ask whether the cac Ca(2+) channel is the Ca(2+) channel solely dedicated for fast synaptic transmission...
  12. ncbi Synaptic calcium-channel function in Drosophila: analysis and transformation rescue of temperature-sensitive paralytic and lethal mutations of cacophony
    Fumiko Kawasaki
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 22:5856-64. 2002
    ..The cacophony (cac) gene in Drosophila, also known as nightblind A, encodes a voltage-gated calcium-channel alpha1 subunit homologous to vertebrate alpha1 subunits implicated in ..
  13. pmc straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit
    Cindy V Ly
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 181:157-70. 2008
    ..These defects likely stem from destabilization of Cacophony (Cac), the primary presynaptic alpha(1) subunit in D. melanogaster...
  14. pmc Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein
    A Ashleigh Long
    Department of Biological Sciences, Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37235 1634, USA
    J Neurosci 28:3668-82. 2008
    ..These data indicate that Fusl regulates assembly of the presynaptic active zone Ca(2+) channel domains required for efficient coupling of the Ca(2+) influx and synaptic vesicle exocytosis during neurotransmission...
  15. pmc Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission
    Jingjun Li
    Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    Neuron 55:741-55. 2007
    ..Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments...
  16. ncbi Drosophila cacophony channels: a major mediator of neuronal Ca2+ currents and a trigger for K+ channel homeostatic regulation
    I Feng Peng
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 27:1072-81. 2007
    The cacophony (cac) locus in Drosophila encodes a Ca2+ channel alpha subunit, but little is known about properties of cac-mediated currents and functional consequences of cac mutations in central neurons...
  17. pmc Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis
    C Andrew Frank
    Department of Biochemistry and Biophysics, Neuroscience Program, University of California, San Francisco, 1550 4th Street, Rock Hall 4th Floor North, San Francisco, California 94158, USA
    Neuron 52:663-77. 2006
    ..1 calcium channel encoded by cacophony. These data confirm the presynaptic expression of synaptic homeostasis and implicate presynaptic Ca(V)2.1 in a homeostatic retrograde signaling system...
  18. ncbi Presynaptic N-type calcium channels regulate synaptic growth
    Gabrielle E Rieckhof
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:41099-108. 2003
    ..a screen for behavioral mutants that disrupt synaptic transmission, an allele of the N-type calcium channel locus (Dmca1A) was identified that caused synaptic undergrowth...
  19. ncbi Non-NMDA-type glutamate receptors are essential for maturation but not for initial assembly of synapses at Drosophila neuromuscular junctions
    Andreas Schmid
    European Neuroscience Institute Göttingen, 37077 Gottingen, Germany
    J Neurosci 26:11267-77. 2006
    ..Thus, our data suggest that incorporation of non-NMDA-type glutamate receptors and likely their protein-protein interactions with additional PSD components triggers a conversion from an initial to a mature stage of PSD assembly...
  20. ncbi Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
    Robert J Kittel
    European Neuroscience Institute Göttingen, Grisebachstrasse 5, 37077 Gottingen, Germany
    Science 312:1051-4. 2006
    ..BRP-like proteins seem to establish proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity...
  21. ncbi Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila
    Fumiko Kawasaki
    Department of Biology and Genetics Graduate Program, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 24:282-5. 2004
    ..Our previous genetic, molecular, and functional analysis has shown that the cacophony (cac) gene encodes a primary presynaptic calcium channel alpha1 subunit in Drosophila...
  22. ncbi Glutamate receptor dynamics organizing synapse formation in vivo
    Tobias M Rasse
    European Neuroscience Institute Göttingen, Max Planck Society, Waldweg 33, D 37073 Gottingen, Germany
    Nat Neurosci 8:898-905. 2005
    ....
  23. pmc Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain
    Huaiyu Gu
    Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA
    J Neurophysiol 101:42-53. 2009
    ..In Drosophila, cac is the only Ca(v)2-type gene...
  24. doi Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function
    Dion K Dickman
    F M Kirby Neurobiology Center, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:31-8. 2008
    ..photoreceptor phenotype of d alpha2delta-3 mutants resembles that of the calcium channel alpha1 mutant cacophony (cac), suggesting shared functions. We have examined in detail genotypes that survive to the third-instar stage...
  25. pmc Transsynaptic control of presynaptic Ca²⁺ influx achieves homeostatic potentiation of neurotransmitter release
    Martin Muller
    Department of Biochemistry and Biophysics, 1550 4 th Street, Rock Hall 4 th Floor North, University of California, San Francisco, San Francisco, CA 94158, USA
    Curr Biol 22:1102-8. 2012
    ..Together with additional analyses, we establish that retrograde, transsynaptic modulation of presynaptic Ca(2+) influx through CaV2.1 channels is a key factor underlying the homeostatic regulation of neurotransmitter release...
  26. doi Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's disease
    Jian Kang Huang
    Department of Neurology, the Sixth People s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
    Neurobiol Dis 51:161-7. 2013
    ..Our study indicates that the chronic accumulation of intraneuronal Aβ can induce functional and structural changes in the presynaptic active zone prior to a loss of presynaptic buttons in the same neuron...
  27. pmc Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response
    Jihye Lee
    Interdisciplinary Program in Neuroscience, The University of Iowa, Iowa City, Iowa, 52242 Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan si, Kyoungsangnam Do, 626 870, Korea
    Dev Neurobiol 74:1-15. 2014
    ..We demonstrate contrasting effects of cac and Dmca1D channels in decreasing transmitter release and muscle excitability, respectively, consistent with their ..
  28. pmc CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning
    John M Gillespie
    School of Physiology and Pharmacology, University of Bristol Bristol, UK
    Front Mol Neurosci 6:27. 2013
    ..Expression of human CASK in Drosophila rescued the effect of CASK deletion on the activity state of CaMKII, suggesting that human CASK may also regulate CaMKII autophosphorylation. ..
  29. pmc Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS
    Jer Cherng Chang
    Department of Integrative Biosciences, Oregon Health and Science University, Portland, OR 97239, USA
    Brain Res 1584:39-51. 2014
    ..If similar effects of cacophony or related calcium channels are found in human ALS patients, these could be targets for the development of pharmacological therapies for ALS...
  30. pmc Miniature neurotransmission regulates Drosophila synaptic structural maturation
    Ben Jiwon Choi
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Neuron 82:618-34. 2014
    ..Our results establish that miniature neurotransmission, a universal but often-overlooked feature of synapses, has unique and essential functions in vivo...
  31. doi A presynaptic role of microtubule-associated protein 1/Futsch in Drosophila: regulation of active zone number and neurotransmitter release
    Simon Lepicard
    Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier, Montpellier, Cedex 5, F 34094, France
    J Neurosci 34:6759-71. 2014
    ..Altogether our data are in favor of a model by which Futsch locally stabilizes active zones, by reinforcing their link with the underlying microtubule cytoskeleton. ..
  32. pmc Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons
    Long Li
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112
    J Neurosci 34:8474-87. 2014
    ....
  33. doi Role of Drosophila calcium channel cacophony in dopaminergic neurodegeneration and neuroprotection
    Lyle Wiemerslage
    Neuroscience Program, Department of Biological Sciences, 213 Life Science Building, Ohio University, Athens, OH 45701, USA Electronic address
    Neurosci Lett 584:342-6. 2015
    ..Our findings support the idea that Ca(2+) is a source of vulnerability for DA neurons and that the modulation of Ca(2+) levels in DA neurons could be a potential neuroprotective treatment...
  34. doi Investigating CNS synaptogenesis at single-synapse resolution by combining reverse genetics with correlative light and electron microscopy
    Olivier Urwyler
    Neuronal Wiring Laboratory, Vesalius Research Center, VIB, Herestraat 49 Box 912, Leuven 3000, Belgium Neuronal Wiring Laboratory, Vesalius Research Center, Department of Oncology, KU Leuven, Herestraat 49 Box 912, Leuven 3000, Belgium
    Development 142:394-405. 2015
    ..In principle, our CLEM approach is broadly applicable to the developmental and ultrastructural analysis of any cell type that can be targeted with genetically encoded markers. ..
  35. pmc A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis
    Xuejun Tian
    Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, China
    PLoS Biol 13:e1002103. 2015
    ..designed to identify genes required for neuronal function and maintenance, we identified multiple cacophony (cac) mutant alleles...
  36. pmc Ih channels control feedback regulation from amacrine cells to photoreceptors
    Wen Hu
    Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China Co innovation Center of Neuroregeneration, Nantong University, Nantong, China
    PLoS Biol 13:e1002115. 2015
    ..These results provide new mechanistic insight into how synaptic feedback regulation can participate in network processing by modulating neural information transfer and circuit excitability. ..
  37. pmc Neuronal processing of noxious thermal stimuli mediated by dendritic Ca(2+) influx in Drosophila somatosensory neurons
    Shin Ichiro Terada
    Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    elife 5:. 2016
    ..The precipitous fluctuation of firing rate in Class IV neurons enhanced the robust heat avoidance. We hypothesize that the Ca(2+) influx can be a key signal encoding a specific modality. ..
  38. pmc C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction
    Ashlyn M Spring
    Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS Genet 12:e1005886. 2016
    ..Based on these data, we propose that Csk and its SFK substrates impinge upon homeostatic control of NMJ function by regulating downstream expression or localization of FasII. ..
  39. pmc Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction
    Haneui Bae
    Department of Biology and Neuroscience Program, Amherst College, Amherst, Massachusetts 01002
    Eneuro 3:. 2016
    ..Our results suggest that although Rab3-GEF acts upstream of Rab3 to control Rab3 localization and likely GTP-binding, it also acts downstream to regulate CAZ development, potentially as a Rab3 effector at the synapse. ..
  40. pmc Sialyltransferase regulates nervous system function in Drosophila
    Elena Repnikova
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    J Neurosci 30:6466-76. 2010
    ..Thus, our data shed light on one of the most ancient functions of sialic acids in metazoan organisms and suggest a possibility that this function is evolutionarily conserved between flies and mammals...
  41. ncbi Mutations and natural genetic variation in the courtship song of Drosophila
    Jennifer M Gleason
    Department of Ecology and Evolutionary Biology, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS, USA
    Behav Genet 35:265-77. 2005
    ..With many new tools in genetic analysis and the multiple Drosophila genome projects currently underway, the ability to relate mutational and quantitative analyses will improve...
  42. doi Two types of Ca2+ channel linked to two endocytic pathways coordinately maintain synaptic transmission at the Drosophila synapse
    H Kuromi
    Faculty of Pharmacy, Iwakimeisei University, Chuoudai, Iwaki, Japan
    Eur J Neurosci 32:335-46. 2010
    ..Thus, intense synaptic transmission is coordinately maintained by synaptic vesicle recycling initiated by Ca(2+) influx through the two types of Ca(2+) channel...
  43. pmc Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement
    Robert A Carrillo
    Pharmacology Department, Yale School of Medicine, New Haven, CT 06520, USA
    Neuron 68:32-44. 2010
    ..Mutations affecting the Sema-2a ligand, the plexin B receptor (plexB), the voltage-gated Ca(v)2.1 calcium channel (cac), or the voltage-gated Na(v)1 sodium channel (mle(nap-ts);tipE) each result in ectopic neuromuscular contacts...
  44. pmc Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila
    Jihye Lee
    Department of Biology, The University of Iowa, Iowa City, IA 52242, USA
    J Neurosci 30:15821-33. 2010
    ....
  45. pmc A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels
    C Andrew Frank
    Department of Biochemistry and Biophysics, 1550 4th Street, Rock Hall 4th Floor North, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 61:556-69. 2009
    ..Based on these data, we propose that Ephexin/Cdc42 couples synaptic Eph signaling to the modulation of presynaptic CaV2.1 channels during the homeostatic enhancement of presynaptic release...
  46. pmc The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction
    Kazuya Tsurudome
    Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada
    Neuron 68:879-93. 2010
    ..Finally, we show that repression of Khc-73 by miR-310-313 cluster influences the establishment of normal synaptic homeostasis. Our findings establish a role for miRNAs in the regulation of neurotransmitter release...
  47. ncbi Molecular evolution of the cacophony IVS6 region in sandflies
    R M M A Lins
    Departamento de Bioquimica e Biologia Molecular, Fundacao Oswaldo Cruz, Av Brazil 4365, Manguinhos, CEP 21045 900, Rio de Janeiro, Brazil
    Insect Mol Biol 11:117-22. 2002
    ..The available cacophony sequences were also used for a phylogenetic analysis of some species of the Neotropical genus Lutzomyia...
  48. pmc Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons
    Stefanie Ryglewski
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    J Physiol 590:809-25. 2012
    ..We further demonstrated that the Ca(v)2 homolog, Dmca1A, mediated the amiloride-insensitive component of LVA current...
  49. pmc Two distinct genomic regions, harbouring the period and fruitless genes, affect male courtship song in Drosophila montana
    M Lagisz
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    Heredity (Edinb) 108:602-8. 2012
    ..In previous studies, the pulse train traits have been found to vary substantially between Drosophila species, and so are potential species recognition signals, while the pulse traits may be more important in intra-specific mate choice...
  50. pmc TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in photoreceptors axons in Drosophila
    Guadalupe Astorga
    Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile
    PLoS ONE 7:e44182. 2012
    ..This work sheds new light on the mechanism of neurotransmitter release in tonic synapses of non-spiking neurons...
  51. ncbi A kinder, gentler genetic analysis of behavior: dissection gives way to modulation
    R J Greenspan
    Neurosciences Institute, San Diego, California 92121, USA
    Curr Opin Neurobiol 7:805-11. 1997
    ..Examples of such variants affecting ion channels, transcription factors and protein kinases in studies of courtship and learning have anticipated recent findings on the naturally occurring variants in circadian rhythms and foraging...
  52. ncbi Model organisms: new insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster
    M R MacPherson
    Institute of Biomedical and Life Sciences, Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, United Kingdom
    Am J Physiol Cell Physiol 280:C394-407. 2001
    ..We have shown by RT-PCR that the Drosophila L-type calcium channel alpha1-subunit genes Dmca1D and Dmca1A (nbA) are both expressed in tubules...
  53. pmc Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophony
    B Dellinger
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 155:203-11. 2000
    ..One of these mutations is a TS paralytic allele of the calcium channel alpha1-subunit gene, cacophony (cac)...
  54. ncbi Genetic lesions in Drosophila behavioural mutants
    G O Pflugfelder
    Theodor Boveri Institut Biozentrum, Lehrstuhl fur Genetik, Universität Würzburg Am Hubland, Germany
    Behav Brain Res 95:3-15. 1998
    ..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations...
  55. pmc The gastrulation defective gene of Drosophila melanogaster is a member of the serine protease superfamily
    K D Konrad
    Developmental Biology Center and the Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 95:6819-24. 1998
    ..These data provide additional support for the involvement of a protease cascade in generating an asymmetric signal (i.e., asymmetric Spätzle activity) during establishment of dorsal-ventral polarity in the Drosophila embryo...
  56. pmc The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
    Dion K Dickman
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Science 326:1127-30. 2009
    ..Thus, dysbindin is essential for adaptive neural plasticity and may link altered homeostatic signaling with a complex neurological disease...
  57. pmc Genomic organization and evolution of alternative exons in a Drosophila calcium channel gene
    A A Peixoto
    Brandeis University, Department of Biology, Waltham, MA 02254 9110, USA
    Genetics 145:1003-13. 1997
    ..It is suggested that this divergence, rather than reflecting evolutionary age, is the likely result of accelerated rates of evolution following duplication...
  58. ncbi The mating of a fly
    J C Hall
    Department of Biology, Brandeis University, Waltham, MA 02254 9110
    Science 264:1702-14. 1994
    ..Further behavioral mutations seemed originally to be courtship-specific, turned out not to have that property, and have led to a broadened perspective on the nature and action of Drosophila's sex-determination genes...
  59. ncbi The effects of zygotic lethal mutations on female germ-line functions in Drosophila
    N Perrimon
    Dev Biol 105:404-14. 1984
    ..Three loci were found which, in germ-line clones, produced embryonic phenotypes that resemble maternal effect mutations. The implications of this study for the genetic analysis of early development are discussed...
  60. pmc Salivary chromosome bands and the frequency of crossing over in Drosophila melanogaster
    G Lefevre
    Genetics 67:497-513. 1971
  61. ncbi Distribution of MR-induced sex-linked recessive lethal mutations in Drosophila melanogaster
    J C Eeken
    Mutat Res 150:261-75. 1985
    ....
  62. pmc The dissonance mutant of courtship song in Drosophila melanogaster: isolation, behavior and cytogenetics
    S J Kulkarni
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    Genetics 118:267-85. 1988
    ..behavior and visual system functions are discussed with respect to the new song mutation (diss) and the older one (cac)--which also turned out to be genetically related to a mutation that causes abnormalities of light-induced behavior ..
  63. pmc Behavioral and cytogenetic analysis of the cacophony courtship song mutant and interacting genetic variants in Drosophila melanogaster
    S J Kulkarni
    Genetics 115:461-75. 1987
    ..Further complementation tests involving cac and other closely linked genetic variants--the night-blind-A (nbA) visual mutation, l(1)L13 lethal mutations, and a series of X chromosomal breakpoints--suggested complex ..
  64. ncbi Some mutations affecting neural or muscular tissues alter the physiological components of the electroretinogram in Drosophila
    T Homyk
    Department of Biological Sciences, Purdue University, W Lafayette, Indiana 47906
    J Neurogenet 5:37-48. 1989
    ..Mutations bas, rex and sesD delay recovery from the prolonged depolarization afterpotential. The visual defects of mutations elavjl and nbAEE171 are not complemented by lethal mutations, which, presumably, affect other tissues...
  65. ncbi The molecular genetics of invertebrate phototransduction
    R Ranganathan
    Dept of Biology, University of California, San Diego, La Jolla 92093
    Trends Neurosci 14:486-93. 1991
    ..The results of a combination of molecular, genetic, physiological and biochemical studies are beginning to produce a clearer model for the complex mechanisms involved in invertebrate visual transduction...
  66. ncbi Artificial neural network classification of Drosophila courtship song mutants
    E K Neumann
    Department of Biology, Brandeis University, Waltham, MA 02254
    Biol Cybern 66:485-96. 1992
    ....
  67. ncbi The behavior of cacophony, a courtship song mutant in Drosophila melanogaster
    F von Schilcher
    Behav Biol 17:187-96. 1976
  68. ncbi A mutation which changes courtship song in Drosophila melanogaster
    F von Schilcher
    Behav Genet 7:251-9. 1977
    ..The pulses are polycyclic rather than monocyclic. Flight wingbeat and sine song frequency remain unchanged. The mutation is mapped and fate-mapped. The results from the latter investigation are inconclusive...
  69. ncbi Temperature-dependent developmental plasticity of Drosophila neurons: cell-autonomous roles of membrane excitability, Ca2+ influx, and cAMP signaling
    I Feng Peng
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 27:12611-22. 2007
    ..Presumably, activity-dependent Ca2+ accumulation triggers the cAMP cascade to confer the activity-dependent plasticity of neuronal excitability and growth...
  70. ncbi Properties of short-term synaptic depression at larval neuromuscular synapses in wild-type and temperature-sensitive paralytic mutants of Drosophila
    Ying Wu
    Department of Biology and Center for Cellular and Molecular Neuroscience, The Pennsylvania State University, University Park, PA 16802, USA
    J Neurophysiol 93:2396-405. 2005
    ....
  71. pmc Tuning of RNA editing by ADAR is required in Drosophila
    Liam P Keegan
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    EMBO J 24:2183-93. 2005
    ..Expression of this transcript in embryonic muscle is also lethal, with above-normal, adult-like levels of editing at sites in a transcript encoding a muscle voltage-gated calcium channel...
  72. ncbi Mutations in and deletions of the Ca2+ channel-encoding gene cacophony, which affect courtship song in Drosophila, have novel effects on heartbeating
    Vanessa M Ray
    Department of Biological Sciences, University of Maine, Orono, Maine, USA
    J Neurogenet 19:39-56. 2005
    ..cacophony (cac) locus of Drosophila melanogaster encodes the a-1 subunit of a voltage gated Ca(2+) channel, termed Dmca1A. A subset of mutations at this locus cause characteristic alterations in the male mating song, manifest as ..
  73. ncbi Evolutionary convergence of alternative splicing in ion channels
    Richard R Copley
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Trends Genet 20:171-6. 2004
    ..The result has important implications for the analysis of regulation of alternative splicing using comparative genomics and our understanding of molecular evolution...
  74. ncbi Rolling blackout is required for synaptic vesicle exocytosis
    Fu De Huang
    Department of Biological Sciences, Kennedy Center for Research on Human Development, Brain Institute, Vanderbilt University, Nashville, Tennessee 37235 1634, USA
    J Neurosci 26:2369-79. 2006
    ..We conclude that RBO plays an essential role in neurotransmitter release, downstream of SV docking, likely mediating SV fusion...
  75. ncbi Claudins in occluding junctions of humans and flies
    Mikio Furuse
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Trends Cell Biol 16:181-8. 2006
    ..Interestingly, claudin-like molecules have recently been identified in septate junctions of Drosophila. Here, we present an overview of recent progress in claudin studies conducted in mammals and flies...
  76. ncbi Ca2+ influx through distinct routes controls exocytosis and endocytosis at drosophila presynaptic terminals
    Hiroshi Kuromi
    Institute for Behavioral Sciences, Gunma University School of Medicine, Maebashi, Japan
    Neuron 41:101-11. 2004
    ..In shibire(ts1), a dynamin mutant, flunarizine or La(3+) inhibited assembly of clathrin at the plasma membrane during stimulation without affecting dynamin function...
  77. ncbi The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation
    G T Macleod
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Eur J Neurosci 23:3230-44. 2006
    ..The cac(ts2) mutant allele of cacophony is associated with paralysis and reduced neurotransmission at non-permissive ..
  78. ncbi Moving from model to non-model organisms? Lessons from Nasonia wasps
    David Shuker
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland
    Bioessays 25:1247-8. 2003
  79. pmc Genetic analysis of a synaptic calcium channel in Drosophila: intragenic modifiers of a temperature-sensitive paralytic mutant of cacophony
    I M Brooks
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 164:163-71. 2003
    ..a temperature-sensitive paralytic mutant of the voltage-gated calcium channel alpha1 subunit gene, cacophony (cac)...
  80. ncbi Courtship lite: a personal history of reproductive behavioral neurogenetics in Drosophila
    Jeffrey C Hall
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurogenet 16:135-63. 2002
  81. ncbi In developing Drosophila neurones the production of gamma-amino butyric acid is tightly regulated downstream of glutamate decarboxylase translation and can be influenced by calcium
    Barbara Küppers
    Institute of Genetics, University of Mainz, J J Becherweg 32, D 55128 Mainz, Germany
    J Neurochem 84:939-51. 2003
    ....
  82. pmc Rab3 dynamically controls protein composition at active zones
    Ethan R Graf
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 64:663-77. 2009
    ..While previous studies of Rab3 have focused on its role in the synaptic vesicle cycle, these findings demonstrate an additional and unexpected function for Rab3 in the localization of presynaptic proteins to active zones...
  83. pmc A Drosophila full-length cDNA resource
    Mark Stapleton
    Berkeley Drosophila Genome Project Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Genome Biol 3:RESEARCH0080. 2002
    ....
  84. pmc Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm
    Eliana Romero
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 57:27-40. 2008
    ..Thus, our data indicate that increased neurotransmission is at the root of neuronal degeneration caused by expanded full-length htt during early stages of pathogenesis...
  85. pmc Courtship and other behaviors affected by a heat-sensitive, molecularly novel mutation in the cacophony calcium-channel gene of Drosophila
    Betty Chan
    Department of Biology, Brandeis University, Waltham, Massachussetts 02454, USA
    Genetics 162:135-53. 2002
    The cacophony (cac) locus of Drosophila melanogaster, which encodes a calcium-channel subunit, has been mutated to cause courtship-song defects or abnormal responses to visual stimuli...
  86. pmc Micro-processing events in mRNAs identified by DHPLC analysis
    Angela Gallo
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Nucleic Acids Res 30:3945-53. 2002
    ..In the homologous Drosophila transcript a micro-exon also encoding two amino acids was found at the same position before the IVS4 helix...
  87. doi MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site
    Beiyan Zou
    Department of Biology, Center for Molecular and Cellular Neuroscience, and Intercollege Graduate Program in Genetics, 201 Life Sciences Building, Pennsylvania State University, University Park, PA 16802, USA
    Biochem J 414:63-71. 2008
    ....
  88. pmc Characterization of voltage-dependent Ca2+ currents in identified Drosophila motoneurons in situ
    Jason W Worrell
    Division of Neurobiology, University of Arizona, Tucson, AZ 85721, USA
    J Neurophysiol 100:868-78. 2008
    ..The Drosophila genome contains three genes with homology to vertebrate voltage-dependent Ca2+ channels: Dmca1A, Dmca1D, and Dmalpha1G...
  89. ncbi Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila
    B S Baker
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 105:13-24. 2001
  90. pmc Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster
    E Ma
    Department of Pediatrics, Section of Respiratory Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    J Clin Invest 107:685-93. 2001
    ..Disruption of the dADAR gene results in totally unedited sodium (Para), calcium (Dmca1A), and chloride (DrosGluCl-alpha) channels, a very prolonged recovery from anoxic stupor, a vulnerability to heat ..
  91. pmc Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants
    Fumiko Kawasaki
    Department of Biology and Center for Molecular and Cellular Neuroscience, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 106:14658-63. 2009
    ..Together, the results reported here establish in vivo contributions of SNAP-25 and NSF to synaptic vesicle trafficking and define molecular mechanisms determining conserved functional properties of short-term depression...
  92. pmc Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions
    Peri T Kurshan
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 12:1415-23. 2009
    ..Our results indicate that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions...
  93. ncbi Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating
    D Yamamoto
    ERATO Yamamoto Behavior Genes Project, Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo, Japan
    Cell Mol Life Sci 56:634-46. 1999
    ..The issue as to how the mutations that reduce female sexual receptiveness, e.g. dissatisfaction (dsf), spinster (spin) and chaste (cht), affect the structure and/or function of this neural center deserves to be addressed urgently...
  94. ncbi A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function
    Ping Wang
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 24:4518-29. 2004
    ..Given the behavioral similarities between disruptions of PGK function in Drosophila and humans, the analysis of nubian animals may reveal conserved neuronal responses associated with altered ATP generation within the brain...
  95. ncbi Genes for sexual behavior
    D Yamamoto
    ERATO Yamamoto Behavior Genes Project, JST, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Biochem Biophys Res Commun 246:1-6. 1998
    ..This strategy of artificial control of fly behavior opens up an avenue for studies to identify the neural center for individual behavioral actions...
  96. ncbi Spectral analysis of courtship songs in behavioral mutants of Drosophila melanogaster
    D A Wheeler
    Behav Genet 19:503-28. 1989
    Spectral analyses were applied to the courtship songs of the mutants cacophony (cac), dissonance (diss), fruitless (fru), and period (per), as well as to the double mutant cac diss...

Research Grants2

  1. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
    ..of chronobiology in this model system may provide insights into the nature of certain rhythm-related disorders of humans, some of which are associated with genetic variations of Drosophila clock gene orthologs [unreadable] [unreadable]..
  2. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
    ..melanogaster ..