bs

Summary

Gene Symbol: bs
Description: blistered
Alias: CG3411, D-SRF, DSRF, DSrf, DSrf/bs, DmSRF, Dmel\CG3411, Group IIc, Mal, SRF, Serf, Srf, bs/DSRF, bs/Dsrf, dSRF, dsrf, l(2)03267, pruned/DSRF, srf, CG3411 gene product from transcript CG3411-RC, CG3411-PA, CG3411-PB, CG3411-PC, SRF, balloon, blistered/DSRF, blistered/Drosophila serum response factor, bs-PA, bs-PB, bs-PC, drosophila serum response factor, pruned, serum response factor
Species: fruit fly

Top Publications

  1. pmc The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
    Wangsun Choi
    Department of Biology, University of North Carolina at Chapel Hill, USA
    Mol Biol Cell 22:2010-30. 2011
  2. ncbi The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development
    M Affolter
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 120:743-53. 1994
  3. ncbi Blistered: a gene required for vein/intervein formation in wings of Drosophila
    D Fristrom
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 120:2661-71. 1994
  4. ncbi Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events
    C Samakovlis
    Department of Biochemistry, Stanford University, CA 94305, USA
    Development 122:1395-407. 1996
  5. ncbi Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system
    T Lee
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
    Genes Dev 10:2912-21. 1996
  6. ncbi Genetic control of epithelial tube fusion during Drosophila tracheal development
    C Samakovlis
    Department of Biochemistry, Stanford University School of Medicine, CA 94305, USA
    Development 122:3531-6. 1996
  7. ncbi branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching
    D Sutherland
    Department of Biochemistry, Beckman Center, Stanford University School of Medicine, California 94305 5307, USA
    Cell 87:1091-101. 1996
  8. ncbi Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing
    F Roch
    Centro de Biologia Molecular Severo Ochoa, Madrid, Spain
    Development 125:1823-32. 1998
  9. ncbi Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs
    B Biehs
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA ucsd edu
    Development 125:4245-57. 1998
  10. ncbi The Drosophila protein Dof is specifically required for FGF signaling
    S Vincent
    Biozentrum, Universität Basel Abt Zellbiologie, Switzerland
    Mol Cell 2:515-25. 1998

Research Grants

Scientific Experts

Detail Information

Publications109 found, 100 shown here

  1. pmc The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
    Wangsun Choi
    Department of Biology, University of North Carolina at Chapel Hill, USA
    Mol Biol Cell 22:2010-30. 2011
    ..Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure...
  2. ncbi The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development
    M Affolter
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 120:743-53. 1994
    The Drosophila homolog of the vertebrate serum response factor (SRF) was isolated by low stringency hybridization...
  3. ncbi Blistered: a gene required for vein/intervein formation in wings of Drosophila
    D Fristrom
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 120:2661-71. 1994
    We have characterized the blistered (bs) locus phenotypically, genetically and developmentally using a set of new bs alleles...
  4. ncbi Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events
    C Samakovlis
    Department of Biochemistry, Stanford University, CA 94305, USA
    Development 122:1395-407. 1996
    ..The combined morphological, marker expression and genetic data support a model in which successive branching events are mechanistically and genetically distinct but coupled through the action of a tracheal gene regulatory hierarchy...
  5. ncbi Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system
    T Lee
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
    Genes Dev 10:2912-21. 1996
    ....
  6. ncbi Genetic control of epithelial tube fusion during Drosophila tracheal development
    C Samakovlis
    Department of Biochemistry, Stanford University School of Medicine, CA 94305, USA
    Development 122:3531-6. 1996
    ..This establishes a simple genetic system to study fusion of epithelial tubes...
  7. ncbi branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching
    D Sutherland
    Department of Biochemistry, Beckman Center, Stanford University School of Medicine, California 94305 5307, USA
    Cell 87:1091-101. 1996
    ....
  8. ncbi Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing
    F Roch
    Centro de Biologia Molecular Severo Ochoa, Madrid, Spain
    Development 125:1823-32. 1998
    ..blistered encodes for a nuclear protein homologous to the mammalian Serum Response Factor and is expressed in presumptive intervein cells of third larval instar and pupal wing discs...
  9. ncbi Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs
    B Biehs
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA ucsd edu
    Development 125:4245-57. 1998
    ..We present a model in which different A/P boundaries organize vein-specific genetic programs to govern the development of individual veins...
  10. ncbi The Drosophila protein Dof is specifically required for FGF signaling
    S Vincent
    Biozentrum, Universität Basel Abt Zellbiologie, Switzerland
    Mol Cell 2:515-25. 1998
    ..Dof is needed in these cells for activation of the MAPK cascade via FGF signaling, but not for activation via other RTK ligands. Dof therefore appears to be committed exclusively to FGFR-mediated signal transduction...
  11. ncbi adrift, a novel bnl-induced Drosophila gene, required for tracheal pathfinding into the CNS
    C Englund
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187 Umea, Sweden
    Development 126:1505-14. 1999
    ....
  12. ncbi Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF
    J Jarecki
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 99:211-20. 1999
    ..Thus, a single growth factor is reiteratively used to pattern each level of airway branching, and the change in branch patterning results from a switch from developmental to physiological control of its expression...
  13. ncbi Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development
    U Nussbaumer
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Mech Dev 96:27-36. 2000
    The Drosophila serum response factor (DSRF) is expressed in the precursors of the terminal tracheal cells and in the future intervein territories of the third instar wing imaginal disc...
  14. ncbi Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila
    C A Conley
    Department of Zoology, University of Wisconsin, Madison, WI 53706, USA
    Development 127:3947-59. 2000
    ..These features strongly suggest that Crossveinless 2 acts extracelluarly or in the secretory pathway to directly potentiate Dpp or Gbb signaling...
  15. ncbi Control of tracheal tubulogenesis by Wingless signaling
    T Chihara
    Genetic Strain Research Center and The Graduate University for Advanced Studies, National Institute of Genetics, Mishima 411 8540, Japan
    Development 127:4433-42. 2000
    ..These activities of Wingless signaling together specify the shape of the dorsal trunk and other fusion branches...
  16. ncbi Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration
    Kalman Somogyi
    European Molecular Biology Laboratory, Developmental Biology Programme, Heidelberg 69117, Germany
    Dev Cell 7:85-93. 2004
    ..We report that this migration requires the activity of the transcriptional factor serum response factor (SRF) and its cofactor MAL-D and present evidence that nuclear accumulation of MAL-D is induced by cell ..
  17. pmc A myocardin-related transcription factor regulates activity of serum response factor in Drosophila
    Zhe Han
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:12567-72. 2004
    b>Serum response factor (SRF) regulates genes involved in cell proliferation, migration, cytoskeletal organization, and myogenesis...
  18. ncbi Activation and repression activities of ash2 in Drosophila wing imaginal discs
    Mireia Angulo
    Departament de Genetica, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Development 131:4943-53. 2004
    ..We show that ash2 is required to sustain the activation of the intervein-promoting genes net and blistered (bs) and to repress rhomboid (rho), a component of the EGF receptor (Egfr) pathway...
  19. ncbi Hedgehog and Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea
    Kagayaki Kato
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo ku Kobe 650 0047, Japan
    Development 131:5253-61. 2004
    ..Orthogonal expression of Hedgehog and Decapentaplegic in the epidermis instructs monopolar extension of the terminal branch along the posterior compartment, thereby matching the pattern of airway growth with that of the epidermis...
  20. ncbi The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing
    Osamu Shimmi
    Department of Genetics Cell Biology and Development, Howard Hughes Medical Institute, University of Minnesota, 6 160 Jackson Hall, Minneapolis, MN 55455, USA
    Dev Biol 282:70-83. 2005
    ..Taken together, these studies suggest that Sog and Cv promote BMP signaling by transporting a BMP heterodimer from the longitudinal veins into the crossvein regions...
  21. ncbi Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis
    Alain C Jung
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Curr Biol 16:1224-31. 2006
    ..Our study suggests that MAGUK proteins might play important roles during AJ remodeling in epithelial morphogenesis...
  22. ncbi Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila
    Carolina Cela
    Institut de Biologia Molecular de Barcelona IBMB Samitier 1 5, 08028 Barcelona, Spain
    Development 133:3115-25. 2006
    ..This finding establishes a link between a developmental pathway governing tracheal formation and cell adhesiveness...
  23. pmc dSno facilitates baboon signaling in the Drosophila brain by switching the affinity of Medea away from Mad and toward dSmad2
    Norma T Takaesu
    School of Life Sciences, Arizona State University, Tempe 85287 4501, USA
    Genetics 174:1299-313. 2006
    ..Pathway switching in target cells is a previously unreported mechanism for regulating TGFbeta signaling and a novel function for Sno/Ski family proteins...
  24. ncbi Characterization of dSnoN and its relationship to Decapentaplegic signaling in Drosophila
    Rosa Barrio
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Dev Biol 306:66-81. 2007
    ....
  25. ncbi Tramtrack regulates different morphogenetic events during Drosophila tracheal development
    Sofia J Araújo
    Institut de Biologia Molecular de Barcelona IBMB CSIC, Parc Cientific de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Development 134:3665-76. 2007
    ..In summary, the involvement of Ttk in different steps of tube morphogenesis identifies it as a key player in tracheal development...
  26. ncbi The detached locus encodes Drosophila Dystrophin, which acts with other components of the Dystrophin Associated Protein Complex to influence intercellular signalling in developing wing veins
    Christina P Christoforou
    Department of Biology and Environmental Science, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Dev Biol 313:519-32. 2008
    ....
  27. doi Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting
    Lazaro Centanin
    Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Dev Cell 14:547-58. 2008
    ..We propose that the autonomous response to hypoxia that occurs in tracheal cells enhances tracheal sensitivity to increasing Branchless levels, and that this mechanism is a cardinal step in hypoxia-dependent tracheal sprouting...
  28. pmc Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation
    Ekaterina Lyulcheva
    Department of Zoology, Oxford University, South Parks Road, Oxford OX1 3PS, UK
    Dev Cell 15:680-90. 2008
    ..We show that pico and lamellipodin share the ability to activate serum response factor (SRF), a transcription factor that responds to reduced G:F-actin ratios via its co-factor Mal...
  29. doi Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing
    Ana Terriente-Félix
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Dev Biol 329:350-61. 2009
    ....
  30. pmc Bap170, a subunit of the Drosophila PBAP chromatin remodeling complex, negatively regulates the EGFR signaling
    Rosaria Rendina
    Dipartimento delle Scienze Biologiche, Universita degli Studi di Napoli Federico II, 80134 Napoli, Italy
    Genetics 186:167-81. 2010
    ..Interestingly, genetic evidence also indicates that Bap170-mediated repression of rho is inhibited by EGFR signaling, suggesting a scenario of mutual antagonism between EGFR signaling and PBAP function...
  31. doi The Drosophila homologue of SRF acts as a boosting mechanism to sustain FGF-induced terminal branching in the tracheal system
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, c Baldiri Reixac, 10 12, 08028 Barcelona, Spain
    Development 138:1269-74. 2011
    Recent data have demonstrated a crucial role for the transcription factor SRF (serum response factor) downstream of VEGF and FGF signalling during branching morphogenesis...
  32. pmc A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system
    Amin S Ghabrial
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA
    PLoS Genet 7:e1002087. 2011
    ....
  33. ncbi The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system
    K Guillemin
    Department of Biochemistry, Stanford University School of Medicine, CA 94305, USA
    Development 122:1353-62. 1996
    ..pruned encodes the Drosophila homologue of serum response factor (SRF), which functions with an ETS domain ternary complex factor as a growth-factor-activated ..
  34. ncbi The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered
    J Montagne
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 122:2589-97. 1996
    ..Here we report that the Drosophila homolog of the mammalian Serum Response Factor gene (DSRF), which encodes a MADS-box containing transcriptional regulator, is expressed in the future ..
  35. ncbi Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling
    Johanna Hemphälä
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Development 130:249-58. 2003
    ....
  36. ncbi Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila
    T Gridley
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, MA 02142
    Development 109:235-42. 1990
    ..In situ hybridization to Drosophila polytene chromosomes localizes the Drosophila homolog to 60B,C on chromosome 2. Several Drosophila lethal mutations also map to this region...
  37. pmc Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster
    M Prout
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Genetics 146:275-85. 1997
    ..Mutations in three other genes (kakapo, kiwi and moa) may also affect cell adhesion or muscle function at hatching. These new mutants provide valuable material for the study of integrin-dependent cell-to-cell adhesion...
  38. ncbi Binding of the Vestigial co-factor switches the DNA-target selectivity of the Scalloped selector protein
    G Halder
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Development 128:3295-305. 2001
    ..The modification of selector protein DNA-binding specificity by co-factors appears to be a general mechanism for regulating their target selectivity in vivo...
  39. ncbi Functional evolution of Hox proteins in arthropods
    Michel Vervoort
    Evolution et Developpement des protostomiens, Centre de Genetique Moleculaire, UPR 2167 CNRS 1, av de la terrasse 91198 Gif sur Yvette Cedex, France
    Bioessays 24:775-9. 2002
    ..Recent reports challenge this idea by highlighting functional evolution of Hox proteins during the evolutionary history of arthropods...
  40. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
    ..Thus, while our results support the existence of Ft-Ds binding and show that it is sufficient to alter PCP, ds expression is permissive or redundant with other PCP cues in much of the wing...
  41. ncbi Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development
    Nam Sung Moon
    Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts 02129, USA
    Dev Cell 9:463-75. 2005
    ..These loss-of-function experiments demonstrate that E2F cannot be classified simply as a pro- or antiapoptotic factor. Instead, the overall role of E2F in the damage response varies greatly and depends on the cellular context...
  42. pmc Different requirements for proteolytic processing of bone morphogenetic protein 5/6/7/8 ligands in Drosophila melanogaster
    Cornelia Fritsch
    School of Life Sciences, University of Sussex, Falmer Brighton BN1 9QG, United Kingdom
    J Biol Chem 287:5942-53. 2012
    ..Our data show that cleavage requirements evolve rapidly, supporting the notion that changes in post-translational processing are used to create functional diversity between BMPs within and between species...
  43. pmc A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors
    Jose P Vaque
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4340, USA
    Mol Cell 49:94-108. 2013
    ....
  44. pmc Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration
    Elisenda Buti
    Developmental Biology Department, Institute of Molecular Biology of Barcelona IBMB CSIC, Barcelona, Spain Cell and Developmental Biology Programme, Institute for Research in Biomedicine IRB Barcelona, Barcelona, Spain
    PLoS ONE 9:e92682. 2014
    ..By doing so, we provide a molecular link between the activation of Hh signalling and increased chemotactic responses during cell migration. ..
  45. doi The Drosophila Chmp1 protein determines wing cell fate through regulation of epidermal growth factor receptor signaling
    Meagan Valentine
    Department of Biomedical Sciences, Marshall University, Huntington, West Virginia
    Dev Dyn 243:977-87. 2014
    ..Chmp1 is an ESCRT-III component and a putative tumor suppressor in humans. However, published data on Chmp1 activity are conflicting and its role during tissue development is not well defined...
  46. pmc Cropped, Drosophila transcription factor AP-4, controls tracheal terminal branching and cell growth
    Matthew Man Kin Wong
    Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong
    BMC Dev Biol 15:20. 2015
    ..To discover more genes involved in terminal branching, we searched for mutants with very few terminal branches using the Kiss enhancer-trap line collection...
  47. doi Deconstructing the complexity of regulating common properties in different cell types: lessons from the delilah gene
    Atalya Nachman
    Department of Genetics, The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa 31096, Israel
    Dev Biol 403:180-91. 2015
    ..These findings suggest that the acquirement of common cellular properties shared by different cell types is embedded within the unique differentiation program dictated to each of these cells by the major determinants of its identity. ..
  48. doi Ligand-binding and constitutive FGF receptors in single Drosophila tracheal cells: Implications for the role of FGF in collective migration
    Gaelle Lebreton
    Institut de Biologia Molecular de Barcelona CSIC and Institute for Research in Biomedicine IRB Barcelona, Barcelona, Catalonia, Spain
    Dev Dyn 245:372-8. 2016
    ....
  49. pmc Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila
    Alexis Gambis
    Howard Hughes Medical Institute, Laboratory of Apoptosis and Cancer, The Rockefeller University, New York, NY 10065, USA
    Dev Biol 351:128-34. 2011
    ..The "Tomato/GFP-FLP/FRT" method allows high-throughput, rapid and precise identification of survival and developmental pathways in living adult PRs at single-cell resolution...
  50. doi Engrailed homeoprotein acts as a signaling molecule in the developing fly
    Sophie Layalle
    Institut de Genetique Humaine, CNRS, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier, France
    Development 138:2315-23. 2011
    ..This report thus suggests that direct signaling with homeoproteins is an evolutionarily conserved phenomenon that is not restricted to neural tissues and involves interactions with bona fide signal transduction pathways...
  51. doi Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila
    Ziguang Liu
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Japan
    Dev Growth Differ 53:822-41. 2011
    ....
  52. pmc Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing
    Jun Chen
    Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 139:2170-6. 2012
    ....
  53. ncbi Mitotic delay dependent survival identifies components of cell cycle control in the Drosophila blastoderm
    D M Ruden
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Development 121:63-73. 1995
    ....
  54. ncbi Changing distributions of extracellular matrix components during early wing morphogenesis in Drosophila
    M A Murray
    Department of Zoology, University of Washington, Seattle 98195
    Dev Biol 168:150-65. 1995
    ..The features include cytoskeletal specializations and certain cell surface and ECM molecules...
  55. ncbi sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
    N Hacohen
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 92:253-63. 1998
    ..sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development...
  56. pmc Translational readthrough in the hdc mRNA generates a novel branching inhibitor in the drosophila trachea
    P Steneberg
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187 Umea, Sweden
    Genes Dev 12:956-67. 1998
    ..We propose that hdc acts non-autonomously in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea...
  57. pmc Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere
    S D Weatherbee
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genes Dev 12:1474-82. 1998
    ..protein and a subset of Wg- and Decapentaplegic-activated genes such as spalt-related, vestigial, Serum Response Factor, and achaete-scute, whose products regulate morphological features that differ between the wing and ..
  58. pmc A screen to identify Drosophila genes required for integrin-mediated adhesion
    E P Walsh
    Wellcome CRC Institute and Department of Biochemistry, Cambridge CB2 1QR, United Kingdom
    Genetics 150:791-805. 1998
    ..Thus several of these loci are good candidates for genes encoding cytoplasmic proteins required for integrin function...
  59. pmc The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila
    G Halder
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706 USA
    Genes Dev 12:3900-9. 1998
    ..Combinatorial regulation by selector proteins and signal transducers is likely to be a general feature of the tissue-specific control of gene expression during organogenesis...
  60. ncbi Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila
    A Baonza
    Centro de Biologia Molecular Severo Ochoa, Cantoblanco 28049, Madrid, Spain
    Mech Dev 80:133-46. 1999
    ..The results show that genes of the Ras signalling pathway are co-operatively involved in the activity of emc during cell proliferation, and later antagonistically during cell differentiation, repressing EMC expression...
  61. ncbi Selector genes and limb identity in arthropods and vertebrates
    S D Weatherbee
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Cell 97:283-6. 1999
  62. ncbi Dpp and Notch specify the fusion cell fate in the dorsal branches of the Drosophila trachea
    P Steneberg
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187, Umea, Sweden
    Mech Dev 87:153-63. 1999
    ....
  63. pmc Functional evolution of the Ultrabithorax protein
    J K Grenier
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 97:704-9. 2000
    ..The inability of OUbx to function like Drosophila Ubx (DUbx) in the embryonic ectoderm indicates that the Ubx protein may have acquired new cofactors or activity modifiers since the divergence of the onychophoran and insect lineages...
  64. ncbi Cell fate choices in Drosophila tracheal morphogenesis
    E Zelzer
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Bioessays 22:219-26. 2000
    ..Tracheal cell fate choices are determined by signaling cascades triggered by signals emanating from the tracheal cells, as well as by ligands produced by adjacent tissues...
  65. ncbi Drawing lines in the Drosophila wing: initiation of wing vein development
    E Bier
    Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093 0349, USA
    Curr Opin Genet Dev 10:393-8. 2000
    ..As a consequence of this constraint, cells lying in a narrow line immediately outside the signal-producing domain are the only cells that can respond to the signal by activating expression of vein-promoting genes...
  66. ncbi The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development
    E M Verheyen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, B C, V5A 1S6, Burnaby, Canada
    Mech Dev 101:119-32. 2001
    ..The expression of nemo during embryogenesis is dynamic and dsRNA inhibition and ectopic expression studies indicate that nemo is essential during embryogenesis...
  67. pmc A systematic screen for dominant second-site modifiers of Merlin/NF2 phenotypes reveals an interaction with blistered/DSRF and scribbler
    D R LaJeunesse
    Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
    Genetics 158:667-79. 2001
    ..Three of these groups, Group IIa/scribbler (also known as brakeless), Group IIc/blistered, and Group IId/net, are known genes, while two appear to be novel...
  68. ncbi The COE--Collier/Olf1/EBF--transcription factors: structural conservation and diversity of developmental functions
    L Dubois
    Centre de Biologie du Developpement, UMR 5547, CNRS Université Paul Sabatier, 118 route de Narbonne 31062 Toulouse cedex 04, France
    Mech Dev 108:3-12. 2001
    ..We also discuss the existence of an evolutionarily conserved pathway linking Notch signalling and COE regulatory functions in various developmental decisions...
  69. pmc Ras1 interacts with multiple new signaling and cytoskeletal loci in Drosophila eggshell patterning and morphogenesis
    J D Schnorr
    Department of Biology, Whitman College, Walla Walla, Washington 99362, USA
    Genetics 159:609-22. 2001
    ..Mutations in Star and l(2)43Bb had no significant effect upon the lambdatop eggshell defect whereas smt3 and dock alleles significantly suppressed the lambdatop phenotype...
  70. ncbi The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis
    K Shim
    Howard Hughes Medical Institute and Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
    Development 128:4923-33. 2001
    ..We propose that Rib is a key regulator of epithelial morphogenesis that promotes migration and morphogenesis of the tracheal cell bodies and apical surface and other morphogenetic movements...
  71. ncbi EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins
    Fernando Roch
    University Museum of Zoology, Department of Zoology, University of Cambridge, Downing Street, Cambridge, UK, CB2 3EJ
    Development 129:993-1002. 2002
    ..Our results support the idea that localised inactivation of transcriptional repressors such as Cic is a rather general mechanism for regulation of target gene expression by the Ras/Raf pathway...
  72. ncbi Short-range cell interactions and cell survival in the Drosophila wing
    Marco Milan
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Dev Cell 2:797-805. 2002
    ..We also present evidence showing that activation of the Notch signal transduction pathway is involved in triggering apoptosis of cells misspecified for their dorsal-ventral position...
  73. ncbi Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors
    Sonia Avila
    Insitituto de Investigaciones Biomédicas CSIC UAM, C Arturo Duperier, Madrid, Spain
    Eur J Biochem 269:3669-77. 2002
    The transcription factor serum response factor (SRF) regulates expression of growth factor-dependent genes and muscle-specific genes in vertebrates. Homologous factors regulate differentiation of some ectodermic tissues in invertebrates...
  74. ncbi Connecting Hh, Dpp and EGF signalling in patterning of the Drosophila wing; the pivotal role of collier/knot in the AP organiser
    Michele Crozatier
    Centre de Biologie du Developpement, UMR 5547 CNRS UPS, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Development 129:4261-9. 2002
    ..A model recapitulating the molecular interplay between the Hh, Dpp and EGF signalling pathways in the wing AP organiser is presented...
  75. ncbi Integrins in development: moving on, responding to, and sticking to the extracellular matrix
    Christian Bökel
    Department of Anatomy, Wellcome Trust Cancer Research UK Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Dev Cell 3:311-21. 2002
    ..Integrins also participate in signaling events that govern tissue differentiation and organogenesis. Finally, adhesion by integrin-mediated junctions allows tissues to withstand mechanical load and is essential for tissue integrity...
  76. ncbi spalt-induced specification of distinct dorsal and ventral domains is required for Drosophila tracheal patterning
    Xavier Franch-Marro
    Institut de Biologia Molecular de Barcelona CSIC, C Jordi Girona 18 26, 08034 Barcelona, Spain
    Dev Biol 250:374-82. 2002
    ..These results indicate that tracheal patterning depends not only on signalling from surrounding cells but also in the different response of the tracheal cells depending on their allocation to the dorsal or ventral domains...
  77. ncbi Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea
    Camilla Englund
    Umea Centre for Molecular Pathogenesis, Umea University, Sweden
    Development 129:4941-51. 2002
    ..We propose that the attractive and repulsive tracheal responses to Slit are mediated by different combinations of Robo and Robo2 receptors on the cell surface...
  78. ncbi Size isn't everything
    David Tyler
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Bioessays 25:5-8. 2003
    ..A recent paper suggests that a hitherto overlooked cellular behaviour governs the size and shape of a growing tissue, and issues a challenge to developmental biologists to identify the molecular mechanisms involved...
  79. ncbi Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis
    Guang Chao Chen
    Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Curr Biol 14:309-13. 2004
    ..can modulate gene expression, in part, by activating LIM kinase (LIMK) and consequently affecting actin-induced SRF transcriptional activity...
  80. pmc Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein
    Kweon Yu
    Section of Cell and Developmental Biology and Center for Molecular Genetics, University of California, San Diego, California 92093 0349, USA
    Genetics 166:1323-36. 2004
    ..Cumulatively, our analysis suggests that CR domains interact physically with adjacent protein sequences to create forms of Sog with distinct BMP modulatory activities...
  81. pmc Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation
    Valerie Petit
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    Mol Cell Biol 24:3769-81. 2004
    ..Additional proteins binding either to the FGFRs, to Dof, or to Csw appear to be crucial for a chemotactic response...
  82. ncbi Papillote and Piopio: Drosophila ZP-domain proteins required for cell adhesion to the apical extracellular matrix and microtubule organization
    Christian Bökel
    Wellcome Trust Cancer Research UK Gurdon Institute and Department of Anatomy, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    J Cell Sci 118:633-42. 2005
    ..Thus, ZP domain-containing proteins may have shared functions within the aECM, while also exhibiting specific interactions with the cytoskeleton...
  83. pmc Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development
    Guang Chao Chen
    Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Mol Cell Biol 25:979-87. 2005
    ..Taken together, these data indicate the importance of paxillin modulation of Rho family GTPases during development and identify the LIMK pathway as a critical target of paxillin-mediated Rho regulation...
  84. ncbi Interactions between the Notch, EGFR, and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development
    Sol Sotillos
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Dev Dyn 232:738-52. 2005
    ..Once dpp expression is initiated, Dpp and EGFR activities in the provein maintain each other and, in cooperation, determine vein cell differentiation...
  85. ncbi Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone
    Amy Ralston
    Department of Zoology, 250 N Mills Street, University of Wisconsin, Madison, WI 53706, USA
    Dev Biol 280:187-200. 2005
    ..However, this requirement can be overridden by co-misexpression of the BMP agonist Cv-2, indicating the presence of as yet unknown cues; we discuss possible candidates...
  86. pmc Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology
    Arnar Palsson
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    BMC Genet 6:44. 2005
    ..This re-evaluation utilized different genetic testcrosses to generate heterozygous individuals with a variety of genetic backgrounds as well as sampling of new alleles from Kenyan stocks...
  87. pmc MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing
    Daniel R Marenda
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 133:43-51. 2006
    ....
  88. ncbi Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila
    Clemens Cabernard
    Department of Biology, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 9:831-42. 2005
    ..Ras and the Mapk pathway are also needed for Egf-regulated cell division/survival, but Pointed is dispensable...
  89. pmc MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 102:18986-91. 2005
    ..Drosophila miR-1 (dmiR-1) is regulated through a serum response factor-like binding site in cardiac progenitor cells...
  90. pmc Dysfusion transcriptional control of Drosophila tracheal migration, adhesion, and fusion
    Lan Jiang
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Cell Biol 26:6547-56. 2006
    ..These results indicate that fusion cells undergo dynamic changes in gene expression as they switch from migratory to fusion modes and that dysfusion regulates a discrete, but important, set of these genes...
  91. ncbi MicroRNAs in muscle differentiation: lessons from Drosophila and beyond
    Hanh T Nguyen
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Opin Genet Dev 16:533-9. 2006
    ..Other miRNAs might promote specific developmental switches during the development and regeneration of muscles...
  92. pmc The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila
    Mihaela Serpe
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 14:940-53. 2008
    ..We also find that Cv-2 expression is controlled by BMP signaling, and these combined properties enable Cv-2 to exquisitely tune BMP signaling...
  93. doi Spalt major controls the development of the notum and of wing hinge primordia of the Drosophila melanogaster wing imaginal disc
    Nicole C Grieder
    Biozentrum der Universtät Basel, Abteilung Zellbiologie, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Dev Biol 329:315-26. 2009
    ..We also find that salm activity is down-regulated by its own product and by that of the Pax gene eyegone...
  94. pmc Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila
    David D O'Keefe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Dev Biol 333:143-60. 2009
    ..Finally, we show that Rap1 acts through the effector Canoe to regulate these developmental processes...
  95. doi In vivo coupling of cell elongation and lumen formation in a single cell
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:359-66. 2010
    ..Given the similarities in the formation of fine respiratory tubes and capillaries, we propose that an inward membrane growth model could account for lumen formation in both processes...
  96. doi Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila
    N Usha
    Centre for Cellular and Molecular Biology, Hyderabad 500007, India
    Dev Biol 341:389-99. 2010
    ..These results suggest a mechanism by which Ci may activate targets such as kn, which do not have classical Ci/Gli-binding sites...
  97. pmc Mal/SRF is dispensable for cell proliferation in Drosophila
    Barry J Thompson
    Cancer Research UK, London Research Institute, London, United Kingdom
    PLoS ONE 5:e10077. 2010
    The Mal/SRF transcription factor is regulated by the level of G-actin in cells and has important roles in cell migration and other actin-dependent processes in Drosophila...
  98. ncbi The knirps and knirps-related genes organize development of the second wing vein in Drosophila
    K Lunde
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093, USA
    Development 125:4145-54. 1998
    ..We propose a model in which the combined activities of kni and knrl organize development of the L2 vein in the appropriate position...
  99. ncbi Insect evolution: Redesigning the fruitfly
    G Gibson
    Department of Genetics, North Carolina State University, Raleigh 27695 7614, USA
    Curr Biol 9:R86-9. 1999
    ....
  100. ncbi Genetic control of branching morphogenesis
    R J Metzger
    Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Science 284:1635-9. 1999
    ..The reiterative use of a signaling pathway by both insects and mammals suggests a general scheme for patterning branching morphogenesis...
  101. ncbi Repression of the wing vein development in Drosophila by the nuclear matrix protein plexus
    H Matakatsu
    Genetic Strain Research Center, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Development 126:5207-16. 1999
    ..Plexus may regulate transcription of vein-and intervein-specific genes by tethering transcriptional regulators to specific locations in the nucleus...

Research Grants1

  1. A new site-specific recombination system in Drosophila
    Georg Halder; Fiscal Year: 2005
    ..These tools will have broad applications and will lead to the discovery of novel genetic interactions in Drosophila that could not have been detected using currently available methods. ..