brp

Summary

Gene Symbol: brp
Description: bruchpilot
Alias: BRP, Brp, CG12932, CG12933, CG1931, CG30336, CG30337, CG34146, CG42344, Cast, Dmel\CG42344, Dmel_CG12932, Dmel_CG34146, MAbnc82, Mabnc82, NC82, Nc82, mAb nc82, mAbnc82, nc-82, nc82, CG42344-PD, CG42344-PE, CG42344-PG, CG42344-PH, CG42344-PI, CG42344-PJ, CG42344-PK, CG42344-PL, CG42344-PM, Nc82, brp-PD, brp-PE, brp-PG, brp-PH, brp-PI, brp-PJ, brp-PK, brp-PL, brp-PM, burchpilot, monoclonal antibody nc82
Species: fruit fly

Top Publications

  1. ncbi Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements
    Chunlai Wu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9557-66. 2005
  2. ncbi Olfactory shifts parallel superspecialism for toxic fruit in Drosophila melanogaster sibling, D. sechellia
    Teun Dekker
    Division of Chemical Ecology, Swedish University of Agricultural Sciences, PO Box 44, Alnarp SE 230 53, Sweden
    Curr Biol 16:101-9. 2006
  3. ncbi Distinct memory traces for two visual features in the Drosophila brain
    Gang Liu
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Nature 439:551-6. 2006
  4. ncbi Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila
    Dhananjay A Wagh
    Lehrstuhl für Genetik und Neurobiologie, Theodor Boveri Institut für Biowissenschaften, Am Hubland, D 97074 Wurzburg, Germany
    Neuron 49:833-44. 2006
  5. ncbi Neural circuitry that governs Drosophila male courtship behavior
    Petra Stockinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:795-807. 2005
  6. pmc Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1
    Ian King
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 31:1139-48. 2011
  7. pmc A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 175:491-503. 2006
  8. pmc The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila
    P Robin Hiesinger
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 121:607-20. 2005
  9. pmc Rab3 dynamically controls protein composition at active zones
    Ethan R Graf
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 64:663-77. 2009
  10. pmc Maturation of active zone assembly by Drosophila Bruchpilot
    Wernher Fouquet
    Institute for Biology Genetics, Free University Berlin, Berlin, Germany
    J Cell Biol 186:129-45. 2009

Research Grants

  1. Regulation of synaptic growth and plasticity in Drosophila
    KATHALEEN O CONNOR GILES; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications105 found, 100 shown here

  1. ncbi Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements
    Chunlai Wu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9557-66. 2005
    ....
  2. ncbi Olfactory shifts parallel superspecialism for toxic fruit in Drosophila melanogaster sibling, D. sechellia
    Teun Dekker
    Division of Chemical Ecology, Swedish University of Agricultural Sciences, PO Box 44, Alnarp SE 230 53, Sweden
    Curr Biol 16:101-9. 2006
    ..sechellia's increased attraction to acids. These findings are a demonstration of evolution acting at several levels in the olfactory circuitry in mediating a fruit fly's unique preference for fruit toxic to its sibling species ...
  3. ncbi Distinct memory traces for two visual features in the Drosophila brain
    Gang Liu
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Nature 439:551-6. 2006
    ..These can be localized to two groups of neurons extending branches as parallel, horizontal strata in the fan-shaped body. The central location of this memory store is well suited to mediate translational invariance...
  4. ncbi Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila
    Dhananjay A Wagh
    Lehrstuhl für Genetik und Neurobiologie, Theodor Boveri Institut für Biowissenschaften, Am Hubland, D 97074 Wurzburg, Germany
    Neuron 49:833-44. 2006
    Neurotransmitters are released at presynaptic active zones (AZs). In the fly Drosophila, monoclonal antibody (MAB) nc82 specifically labels AZs. We employ nc82 to identify Bruchpilot protein (BRP) as a previously unknown AZ component...
  5. ncbi Neural circuitry that governs Drosophila male courtship behavior
    Petra Stockinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:795-807. 2005
    ..This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent...
  6. pmc Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1
    Ian King
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 31:1139-48. 2011
    ....
  7. pmc A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 175:491-503. 2006
    ..We propose a model in which a postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged...
  8. pmc The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila
    P Robin Hiesinger
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 121:607-20. 2005
    ..Our data suggest that Vha100-1 functions downstream of SNAREs in synaptic vesicle fusion...
  9. pmc Rab3 dynamically controls protein composition at active zones
    Ethan R Graf
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 64:663-77. 2009
    ..Late addition of Rab3 to mutant NMJs rapidly reverses this phenotype by recruiting Brp to sites previously lacking the protein, demonstrating that Rab3 can dynamically control the composition of the ..
  10. pmc Maturation of active zone assembly by Drosophila Bruchpilot
    Wernher Fouquet
    Institute for Biology Genetics, Free University Berlin, Berlin, Germany
    J Cell Biol 186:129-45. 2009
    ..Recently, mutants of the Drosophila melanogaster ERC/CAST family protein Bruchpilot (BRP) were shown to lack dense projections (T-bars) and to suffer from Ca(2+) channel-..
  11. ncbi Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions
    Lora B Sweeney
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Neuron 53:185-200. 2007
    ..We propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arriving ORN axons constrain the target choices of late-arriving axons...
  12. ncbi Presynaptic spectrin is essential for synapse stabilization
    Jan Pielage
    Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Curr Biol 15:918-28. 2005
    ..Precise neural circuitry is established and maintained through a regulated balance of synapse stabilization and disassembly. Currently, little is known about the molecular mechanisms that specify synapse stability versus disassembly...
  13. ncbi A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
    Amina Kurtovic
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 446:542-6. 2007
    ..Thus, activation of a single ORN class is both necessary and sufficient to mediate behavioural responses to the Drosophila sex pheromone cVA...
  14. pmc Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris
    Yuly Fuentes-Medel
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 7:e1000184. 2009
    ....
  15. pmc The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
    Dion K Dickman
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Science 326:1127-30. 2009
    ..Thus, dysbindin is essential for adaptive neural plasticity and may link altered homeostatic signaling with a complex neurological disease...
  16. doi Drosophila ankyrin 2 is required for synaptic stability
    Iris Koch
    Max Planck Institute for Developmental Biology, Department III Genetics, Spemannstrasse 35, 72076 Tubingen, Germany
    Neuron 58:210-22. 2008
    ..Interestingly, Ank2 functions downstream of spectrin in the anchorage of synaptic microtubules, providing the cytoskeletal scaffold that is essential for synaptic stability...
  17. doi Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions
    Daniel Banovic
    University of Munster, Institute for Neurobiology, Munster, Germany
    Neuron 66:724-38. 2010
    ..Instead, other signaling components are likely involved in DNlg1 transsynaptic functions, with essential interactions organized by the DNlg1 extracellular domain but also by the cytoplasmic domain...
  18. pmc Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling
    Alex C Koon
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Neurosci 14:190-9. 2011
    ..Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range...
  19. ncbi Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 25:9069-79. 2005
    ....
  20. pmc A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila
    David Owald
    Department of Genetics, Institute for Biology, Freie Universitat Berlin, 14195 Berlin, Germany
    J Cell Biol 188:565-79. 2010
    ..At the Drosophila neuromuscular junction, the ELKS family member Bruchpilot (BRP) is essential for dense body formation and functional maturation of AZs...
  21. pmc The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis
    Christopher J Potter
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 141:536-48. 2010
    ..The Q system can be expanded to other uses in Drosophila and to any organism conducive to transgenesis...
  22. pmc Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton
    Catherine M Massaro
    Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 187:101-17. 2009
    ....
  23. ncbi Highwire restrains synaptic growth by attenuating a MAP kinase signal
    Catherine A Collins
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Neuron 51:57-69. 2006
    ..In addition to controlling synaptic growth, Highwire promotes synaptic function through a separate pathway that does not require wallenda...
  24. pmc Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity
    Zhengmei Mao
    Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX, USA
    Front Neural Circuits 3:5. 2009
    ..Differences in functional response properties of these neurons suggest that they are involved in different behavioral processes...
  25. pmc Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog
    Bruno Marie
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158 2822, USA
    J Neurosci 30:8071-82. 2010
    ....
  26. ncbi Neuropil pattern formation and regulation of cell adhesion molecules in Drosophila optic lobe development depend on synaptobrevin
    P R Hiesinger
    University of Freiburg, Institute of Biology III, D 79104 Freiburg, Germany
    J Neurosci 19:7548-56. 1999
    ..A possible causal link to fine-tuning processes that may include synaptic plasticity in the development of the Drosophila CNS is discussed...
  27. ncbi The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain
    Andrea Mahr
    Max Planck Institut fur Entwicklungsbiologie, Abt III Genetik, Spemannstr 35, 72076 Tubingen, Germany
    Gene Expr Patterns 6:299-309. 2006
    ..Given that vesicular glutamate transporters are essential for the uptake of the neurotransmitter glutamate into synaptic vesicles these tools provide a means to test gene function in these functionally important neurons...
  28. pmc A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels
    C Andrew Frank
    Department of Biochemistry and Biophysics, 1550 4th Street, Rock Hall 4th Floor North, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 61:556-69. 2009
    ..Based on these data, we propose that Ephexin/Cdc42 couples synaptic Eph signaling to the modulation of presynaptic CaV2.1 channels during the homeostatic enhancement of presynaptic release...
  29. pmc Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth
    Kate M O'Connor-Giles
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Neuron 58:507-18. 2008
    ..We propose that Nwk functions at the interface of endocytosis and BMP signaling to ensure proper synaptic growth by negatively regulating Tkv to set limits on this positive growth signal...
  30. ncbi Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth
    Bruno Marie
    Department of Biochemistry and Biophysics, 1550 4th Street, GDBS Fourth Floor North, University of California, San Francisco, 94143, USA
    Neuron 43:207-19. 2004
    ..We present a model in which Dap160 scaffolds both endocytic machinery and essential synaptic signaling systems to the periactive zone to coordinately control structural and functional synapse development...
  31. ncbi Target neuron prespecification in the olfactory map of Drosophila
    G S Jefferis
    Neurosciences Program, Department of Biological Sciences, Stanford University, CA 94305, USA
    Nature 414:204-8. 2001
    ..These studies also imply a previously unanticipated role for precise dendritic targeting by postsynaptic neurons in determining connection specificity...
  32. ncbi Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
    Robert J Kittel
    European Neuroscience Institute Göttingen, Grisebachstrasse 5, 37077 Gottingen, Germany
    Science 312:1051-4. 2006
    ..The Drosophila coiled-coil domain protein Bruchpilot (BRP) was observed in donut-shaped structures centered at active zones of neuromuscular synapses by using subdiffraction ..
  33. pmc Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling
    Bulent Ataman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neuron 57:705-18. 2008
    ..We propose that activation of the postsynaptic Wg pathway is required for the assembly of the postsynaptic apparatus, while activation of the presynaptic Wg pathway regulates cytoskeletal dynamics...
  34. pmc MicroRNA processing pathway regulates olfactory neuron morphogenesis
    Daniela Berdnik
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 18:1754-9. 2008
    ..However, Argonaute-1 and Argonaute-2 are dispensable for PN morphogenesis. Our findings suggest a role for the miRNA processing pathway in establishing wiring specificity in the nervous system...
  35. ncbi Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila
    Shovon I Ashraf
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 124:191-205. 2006
    ..Therefore, we propose that degradative control of the RISC pathway underlies the pattern of synaptic protein synthesis associated with a stable memory...
  36. pmc Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila
    Vanessa Nieratschker
    Department of Genetics and Neurobiology, Julius Maximilians University, Wurzburg, Germany
    PLoS Genet 5:e1000700. 2009
    ..In Drosophila the Bruchpilot (BRP) protein is associated with T-shaped ribbons ("T-bars") at presynaptic active zones (AZs)...
  37. doi Activity-dependent site-specific changes of glutamate receptor composition in vivo
    Andreas Schmid
    Institute for Clinical Neurobiology, Medical Faculty, University of Wurzburg, Zinklesweg 10, 97080 Wurzburg, Germany
    Nat Neurosci 11:659-66. 2008
    ..Thus, we show that an activity-dependent, site-specific control of GluR composition can contribute to match pre- and postsynaptic assembly...
  38. doi Clonal analysis of Drosophila antennal lobe neurons: diverse neuronal architectures in the lateral neuroblast lineage
    Sen Lin Lai
    Department of Neurobiology, University of Massachusetts, Worcester, MA 01605, USA
    Development 135:2883-93. 2008
    ..These systematic cell lineage analyses have not only filled gaps in the olfactory map, but have also exemplified additional strategies used in the brain to increase neuronal diversity...
  39. ncbi Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity
    Sijun Zhu
    Department of Cell and Developmental Biology, University of Illinois, Urbana, 61801, USA
    Cell 127:409-22. 2006
    ..Taken together, we suggest that a temporal gradient of Chinmo (Chinmo(high) --> Chinmo(low)) helps specify distinct birth order-dependent cell fates in an extended neuronal lineage...
  40. doi The Drosophila pheromone cVA activates a sexually dimorphic neural circuit
    Sandeep Robert Datta
    Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 452:473-7. 2008
    ..The observation that cVA activates a sexually dimorphic circuit in the protocerebrum suggests a mechanism by which a single pheromone can elicit different behaviours in males and in females...
  41. pmc PP2A and GSK-3beta act antagonistically to regulate active zone development
    Natasha M Viquez
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:11484-94. 2009
    ..When PP2A is inhibited presynaptically, many glutamate receptor clusters are unapposed to Bruchpilot (Brp), an active zone protein required for normal transmitter release...
  42. pmc Comprehensive maps of Drosophila higher olfactory centers: spatially segregated fruit and pheromone representation
    Gregory S X E Jefferis
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 128:1187-203. 2007
    ..Our results suggest that the LH is organized according to biological values of olfactory input...
  43. pmc Twin-spot MARCM to reveal the developmental origin and identity of neurons
    Hung Hsiang Yu
    Department of Neurobiology, University of Massachusetts, Worcester, USA
    Nat Neurosci 12:947-53. 2009
    ..In sum, twin-spot MARCM can reveal the developmental origins of neurons and the mechanisms that underlie cell fate...
  44. doi Drosophila RSK negatively regulates bouton number at the neuromuscular junction
    Matthias Fischer
    Institute for Clinical Neurobiology, University of Wurzburg, Würzburg 97078, Germany
    Dev Neurobiol 69:212-20. 2009
    ..These experiments provided evidence that RSK mediates its negative effect on bouton formation at the Drosophila NMJ by inhibition of ERK signaling...
  45. pmc A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158 2822, USA
    Neuron 58:195-209. 2008
    ..We propose that a presynaptic Ank2-L lattice links synaptic membrane proteins and spectrin to the underlying microtubule cytoskeleton to organize and stabilize the presynaptic terminal...
  46. pmc Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction
    Rebecca E James
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Development 138:3273-86. 2011
    ..We present a model whereby this inhibition permits the muscle-derived Gbb pool to predominate at the NMJ, thus establishing the retrograde directionality of the pro-growth BMP pathway...
  47. pmc Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release
    Tanja Wucherpfennig
    Max Planck Institut für molekulare Zellbiologie und Genetik, Dresden, Germany
    J Cell Biol 161:609-24. 2003
    ..Conversely, Rab5 overexpression increases the release efficacy. Therefore, the Rab5-dependent trafficking pathway plays an important role for synaptic performance...
  48. doi Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory
    Stephan Knapek
    Max Planck Institut fur Neurobiologie, 82152 Martinsried, Germany
    J Neurosci 31:3453-8. 2011
    ..Here we report that Bruchpilot (Brp), a ubiquitous presynaptic active zone protein, is required for olfactory memory...
  49. pmc Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction
    Misao E Higashi-Kovtun
    FM Kirby Center for Neurobiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 30:5253-68. 2010
    ..Thus, importin-beta11 function interacts with the BMP pathway to regulate a pool of pMAD that must be present at the presynapse for its proper development and function...
  50. ncbi Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions
    Takaki Komiyama
    Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 7:819-25. 2004
    ..We propose that the precision of ORN axon targeting derives from both intrinsic transcriptional control and extensive axon-axon interactions...
  51. ncbi A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
    Sarah Huntwork
    The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Building 46, Room 3243, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:1235-7. 2007
    ....
  52. ncbi Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology
    Jesús Romero-Pozuelo
    Instituto Cajal, CSIC, Ave Dr Arce 37, Madrid 28002, Spain
    Eur J Neurosci 26:2428-43. 2007
    ..We conclude that Frqs have two distinct functions: one in neurotransmission, regulating the probability of release per synapse, and another in axonal growth and bouton formation...
  53. pmc Negative regulation of active zone assembly by a newly identified SR protein kinase
    Ervin L Johnson
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA
    PLoS Biol 7:e1000193. 2009
    ..The SRPK79D protein colocalizes with the T-bar-associated protein Bruchpilot (Brp) in both the axon and synapse...
  54. doi Neuronal assemblies of the Drosophila mushroom body
    Nobuaki K Tanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    J Comp Neurol 508:711-55. 2008
    ..Structural differences between lobes are also discussed...
  55. ncbi Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles
    Kyle E Miller
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 15:684-9. 2005
    ..It suggests the synaptic strength and morphology defects linked to Liprin-alpha may in part be due to a failure in the delivery of synaptic-vesicle precursors...
  56. ncbi Smell and taste perception in Drosophila melanogaster larva: toxin expression studies in chemosensory neurons
    G Heimbeck
    Institute of Zoology and Program in Neuroscience, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Neurosci 19:6599-609. 1999
    ..Hence, a subset of neurons from the TO builds an anatomical entity with projections from the DO. Our results suggest that the AMC contains both olfactory and gustatory sensilla, and that the DO is the main olfactory organ in larvae...
  57. ncbi Altered representation of the spatial code for odors after olfactory classical conditioning; memory trace formation by synaptic recruitment
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 USA
    Neuron 42:437-49. 2004
    ..The rapid recruitment by conditioning of new synapses into the representation of sensory information may be a general mechanism underlying many forms of short-term memory...
  58. ncbi Three-dimensional reconstruction of the antennal lobe in Drosophila melanogaster
    P P Laissue
    Institute of Zoology and Program in Neuroscience, University of Fribourg, Switzerland
    J Comp Neurol 405:543-52. 1999
    ..melanogaster, based on confocal microscopic analysis of glomeruli stained with the neuropil-specific monoclonal antibody nc82. The analysis of confocal stacks allowed us to identify glomeruli according to the criteria shape, size, ..
  59. pmc Unc-51 controls active zone density and protein composition by downregulating ERK signaling
    Yogesh P Wairkar
    Department of Developmental Biology, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 29:517-28. 2009
    ..The Unc-51-dependent inhibition of ERK activity provides a potential mechanism for synapse-specific control of active zone protein composition and release probability...
  60. ncbi Development of the Drosophila mushroom bodies: elaboration, remodeling and spatial organization of dendrites in the calyx
    Sijun Zhu
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Development 130:2603-10. 2003
    ..Taken together, subregional differences exist in the adult Drosophila MB calyx, where processing and integration of distinct types of sensory information begin...
  61. ncbi The Drosophila standard brain
    Karlheinz Rein
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, 97074 Wurzburg, Germany
    Curr Biol 12:227-31. 2002
    ..We now provide a representative standard for the brain of D. melanogaster wild-type with means and variances for several aspects of its shape. Its application to volumetry, mutants, and gene expression patterns is demonstrated...
  62. pmc Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission
    Jingjun Li
    Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    Neuron 55:741-55. 2007
    ..Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments...
  63. ncbi A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport
    Eunju Pack-Chung
    Program in Neurobiology, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 10:980-9. 2007
    ..Our data thus indicate that Imac transports components required for synaptic maturation and provide insight into presynaptic maturation as a process that can be differentiated from axon outgrowth and targeting...
  64. ncbi Non-NMDA-type glutamate receptors are essential for maturation but not for initial assembly of synapses at Drosophila neuromuscular junctions
    Andreas Schmid
    European Neuroscience Institute Göttingen, 37077 Gottingen, Germany
    J Neurosci 26:11267-77. 2006
    ..Thus, our data suggest that incorporation of non-NMDA-type glutamate receptors and likely their protein-protein interactions with additional PSD components triggers a conversion from an initial to a mature stage of PSD assembly...
  65. ncbi Glutamate receptor dynamics organizing synapse formation in vivo
    Tobias M Rasse
    European Neuroscience Institute Göttingen, Max Planck Society, Waldweg 33, D 37073 Gottingen, Germany
    Nat Neurosci 8:898-905. 2005
    ....
  66. ncbi Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:858-63. 2005
    ..Postsynaptic Ca2+ influx also stimulates local synaptic differentiation and growth through Syt 4-mediated retrograde signals in a synapse-specific manner...
  67. ncbi Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons
    Takaki Komiyama
    Department of Biological Sciences and Neurosciences Program, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 128:399-410. 2007
    ..Thus, graded expression of Sema-1a contributes to connection specificity from ORNs to PNs and then to higher brain centers, ensuring proper representation of olfactory information in the brain...
  68. ncbi Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
    Xiankun Zeng
    Department of Genetics and Developmental Biology, Genetics Research Center, Southeast University Medical School, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China
    FEBS Lett 581:2509-16. 2007
    ..The synapse number is decreased in central nervous system in Neurexin-1 null mutants. In addition, Neurexin-1 null mutants exhibit associative learning defect in larvae...
  69. pmc Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP
    Bulent Ataman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Proc Natl Acad Sci U S A 103:7841-6. 2006
    ..These results provide a mechanism by which DFz2 is transported from the postsynaptic membrane to the postsynaptic nucleus during synapse formation and implicate dGRIP as an essential molecule in the transport of this signal...
  70. ncbi Postsynaptic mad signaling at the Drosophila neuromuscular junction
    Veronica Dudu
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Biol 16:625-35. 2006
    ..There is evidence that a retrograde, presynaptic transforming growth factor-beta (TGF-beta) signaling event regulates synapse development and function in Drosophila...
  71. doi Drosophila growth cones: a genetically tractable platform for the analysis of axonal growth dynamics
    Natalia Sánchez-Soriano
    Faculty of Life Sciences, Wellcome Trust Centre for Cell Matrix Research, Manchester M13 9PT, United Kingdom
    Dev Neurobiol 70:58-71. 2010
    ..We demonstrate these events to be mediated by the actin-MT linking factor Short stop, thus identifying an essential molecular player in this context...
  72. ncbi Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms
    Adrian Rothenfluh
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 127:199-211. 2006
    ..The RC transcript mediates the sedating effects of ethanol, while the RA transcript regulates its stimulant effects. Thus, distinct RhoGAPs, encoded by the same gene, regulate different manifestations of acute ethanol intoxication...
  73. pmc Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction
    Nikolaos Giagtzoglou
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 29:5628-39. 2009
    ..Interestingly, imp13 is required in the muscles to control presynaptic release. Thus, imp13 is a novel factor that affects neurotransmitter release at the fly NMJ. Its role in the context of synaptic homeostasis is discussed...
  74. ncbi Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam
    Thomas Hummel
    Howard Hughes Medical Institute, Department of Biological Chemistry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 37:221-31. 2003
    ..Multiple forms of Dscam RNA were detected in the developing antenna, and Dscam protein was localized to developing ORN axons. We propose a role for Dscam protein diversity in regulating ORN target specificity...
  75. pmc Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions
    Peri T Kurshan
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 12:1415-23. 2009
    ..Our results indicate that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions...
  76. ncbi The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction
    Natasha M Viquez
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:9293-303. 2006
    ..Hence, wrd promotes the function of PP2A and is required for normal cytoskeletal organization, synaptic growth, and synaptic function at the Drosophila NMJ...
  77. doi Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis
    Tzu Yang Lin
    Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli 35053, Taiwan
    Development 136:3099-107. 2009
    ..These data suggest that abi and Abl have an antagonistic interaction in Drosophila axonogenesis and synaptogenesis, which possibly occurs through the modulation of F-actin reorganization...
  78. pmc Engrailed expression in subsets of adult Drosophila sensory neurons: an enhancer-trap study
    Jonathan M Blagburn
    Institute of Neurobiology and Department of Physiology, University of Puerto Rico Medical Sciences Campus, Puerto Rico, USA
    Invert Neurosci 8:133-46. 2008
    ..Finally, en-driven GFP is expressed in a single multidendritic sensory neuron in each abdominal segment...
  79. pmc Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity
    R Grace Zhai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 4:e416. 2006
    ..Our data indicate an NAD-independent requirement of NMNAT for maintaining neuronal integrity that can be exploited to protect neurons from neuronal activity-induced degeneration by overexpression of the protein...
  80. pmc Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development
    Tong Wey Koh
    Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 178:309-22. 2007
    ..Based on these data, we hypothesize that Eps15 and Dap160 promote the efficiency of endocytosis from the plasma membrane by maintaining high concentrations of multiple endocytic proteins, including dynamin, at synapses...
  81. ncbi An essential role for a CD36-related receptor in pheromone detection in Drosophila
    Richard Benton
    Laboratory of Neurogenetics and Behaviour, The Rockefeller University, 1230 York Avenue, Box 63, New York, New York 10065, USA
    Nature 450:289-93. 2007
    ....
  82. pmc C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo
    Carin A Loewen
    Molecular, Cellular, and Integrative Neuroscience Program, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Mol Biol Cell 17:5211-26. 2006
    ..Together, our results demonstrate that the polylysine motif is required for efficient Ca2+-independent docking and/or priming of synaptic vesicles in vivo...
  83. pmc Heterogeneity in synaptic transmission along a Drosophila larval motor axon
    Giovanna Guerrero
    Department of Molecular and Cell Biology, 279 Life Sciences Addition, University of California Berkeley, Berkeley, California 94720, USA
    Nat Neurosci 8:1188-96. 2005
    ..The results suggest that transmission strength is mainly determined presynaptically at the level of individual boutons, possibly by one or more factors existing in a gradient...
  84. ncbi Glomerular maps without cellular redundancy at successive levels of the Drosophila larval olfactory circuit
    Ariane Ramaekers
    Department of Biology, University of Fribourg, Chemin du Musee 10, CH 1700 Fribourg, Switzerland
    Curr Biol 15:982-92. 2005
    ..Does this suggest that the larval olfactory system is built according to a different design than its adult counterpart, or is it just a miniature version thereof?..
  85. pmc Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems
    Pelin Cayirlioglu
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 319:1256-60. 2008
    ..We propose that this hybrid ORN reveals a cellular intermediate in the evolution of species-specific behaviors elicited by CO2...
  86. ncbi Afferent induction of olfactory glomeruli requires N-cadherin
    Thomas Hummel
    Howard Hughes Medical Institute, Department of Biological Chemistry, Geffen School of Medicine, Molecular Biology Institute, Box 951662, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 42:77-88. 2004
    ..We propose that N-cad, a homophilic cell adhesion molecule, acts in a permissive fashion to promote subclass-specific sorting of ORN axon terminals into protoglomeruli...
  87. pmc Dscam diversity is essential for neuronal wiring and self-recognition
    Daisuke Hattori
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA
    Nature 449:223-7. 2007
    ..We conclude that Dscam diversity provides each neuron with a unique identity by which it can distinguish its own processes from those of other neurons, and that this self-recognition is essential for wiring the Drosophila brain...
  88. pmc The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila
    Hong Bao
    Section of Neurobiology, The University of Texas at Austin, Austin, TX 78712, USA
    Mol Cell Neurosci 34:662-78. 2007
    ..These findings shed new light on a possible role for Flamingo in progressive neurodegenerative diseases...
  89. pmc In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2
    Hiroshi Kohsaka
    Department of Physics, Graduate School of Science, Graduate School of Frontier Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Cell Biol 179:1289-300. 2007
    ..We propose that Fas2 mediates trans-synaptic adhesion, which contributes to postsynaptic molecular assembly at the onset of synaptogenesis...
  90. ncbi Preferential localization of glutamate receptors opposite sites of high presynaptic release
    Scott B Marrus
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110 USA
    Curr Biol 14:924-31. 2004
    ..Hence, this is an ideal preparation for the investigation of whether receptor clustering is sensitive to the morphological and physiological properties of the apposed active zones...
  91. pmc straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit
    Cindy V Ly
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 181:157-70. 2008
    ....
  92. ncbi Olfactory neurons expressing identified receptor genes project to subsets of glomeruli within the antennal lobe of Drosophila melanogaster
    Sheetal Bhalerao
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    J Neurobiol 54:577-92. 2003
    ..This finding has important implications for our understanding of odor coding and the generation of olfactory behavior...
  93. ncbi Diverse functions of N-cadherin in dendritic and axonal terminal arborization of olfactory projection neurons
    Haitao Zhu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 42:63-75. 2004
    ..Although the N-cadherin locus potentially encodes eight alternatively spliced isoforms, transgenic expression of one isoform is sufficient to rescue all phenotypes...
  94. ncbi Taste representations in the Drosophila brain
    Zuoren Wang
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, 291 Life Sciences Addition, University of California, Berkeley, Berkeley, California 94720, USA
    Cell 117:981-91. 2004
    ..These studies reveal the gustatory map in the first relay of the fly brain and demonstrate that taste quality and position are represented in anatomical projection patterns...
  95. ncbi Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction
    Mattias C Larsson
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 43:703-14. 2004
    ..Consistent with this cellular defect, the Or83b mutation disrupts behavioral and electrophysiological responses to many odorants. Or83b therefore encodes an atypical odorant receptor that plays an essential general role in olfaction...
  96. ncbi Glutamatergic innervation of the heart initiates retrograde contractions in adult Drosophila melanogaster
    Davide Dulcis
    Arizona Research Laboratories Division of Neurobiology, University of Arizona, Tucson, Arizona 85721 0077, USA
    J Neurosci 25:271-80. 2005
    ..Cardiac reversal was evoked pharmacologically by sequentially applying CCAP and glutamate to the heart...
  97. ncbi Coexpression of two functional odor receptors in one neuron
    Aaron L Goldman
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Neuron 45:661-6. 2005
    ..Most importantly, their coexpression has been conserved for >45 million years. Expression of multiple odor receptors in a cell provides an additional degree of freedom for odor coding...
  98. pmc An isoform-specific allele of Drosophila N-cadherin disrupts a late step of R7 targeting
    Aljoscha Nern
    Department of Biological Chemistry, David Geffen School of Medicine, University of California and Howard Hughes Medical Institute, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:12944-9. 2005
    ..Transgene rescue experiments suggest that differences in isoform expression, rather than biochemical differences between isoforms, underlie the 18A isoform requirement in R7 neurons...
  99. ncbi Lim kinase regulates the development of olfactory and neuromuscular synapses
    Lay Hong Ang
    Department of Cell and Developmental Biology and Neuroscience Program, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Dev Biol 293:178-90. 2006
    ..These results establish Limk as a critical regulator of Cofilin function and synapse development, and a downstream effector of Pak in vivo...
  100. ncbi Altered synaptic development and active zone spacing in endocytosis mutants
    Dion K Dickman
    Division of Neuroscience, Children s Hospital, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 16:591-8. 2006
    ..We propose that endocytosis plays a critical role in sculpting the structure of synapses, perhaps through the endocytosis of unknown regulatory signals that organize morphogenesis at synaptic terminals...
  101. ncbi Wiring stability of the adult Drosophila olfactory circuit after lesion
    Daniela Berdnik
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    J Neurosci 26:3367-76. 2006
    ..We conclude that, although adult olfactory neurons can undergo plastic changes in response to the loss of competition, the olfactory circuit overall is extremely stable in preserving segregated information channels in this discrete map...

Research Grants1

  1. Regulation of synaptic growth and plasticity in Drosophila
    KATHALEEN O CONNOR GILES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..