brp

Summary

Gene Symbol: brp
Description: bruchpilot
Alias: BRP, Brp, CG12932, CG12933, CG1931, CG30336, CG30337, CG34146, CG42344, Cast, Dmel\CG42344, Dmel_CG12932, Dmel_CG34146, MAbnc82, Mabnc82, NC82, Nc82, mAb nc82, mAbnc82, nc-82, nc82, CG42344 gene product from transcript CG42344-RJ, CG42344-PD, CG42344-PE, CG42344-PG, CG42344-PH, CG42344-PI, CG42344-PJ, CG42344-PK, CG42344-PL, CG42344-PM, Nc82, brp-PD, brp-PE, brp-PG, brp-PH, brp-PI, brp-PJ, brp-PK, brp-PL, brp-PM, burchpilot, monoclonal antibody nc82
Species: fruit fly

Top Publications

  1. ncbi Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements
    Chunlai Wu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9557-66. 2005
  2. ncbi Distinct memory traces for two visual features in the Drosophila brain
    Gang Liu
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Nature 439:551-6. 2006
  3. ncbi Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila
    Dhananjay A Wagh
    Lehrstuhl für Genetik und Neurobiologie, Theodor Boveri Institut für Biowissenschaften, Am Hubland, D 97074 Wurzburg, Germany
    Neuron 49:833-44. 2006
  4. ncbi Neural circuitry that governs Drosophila male courtship behavior
    Petra Stockinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:795-807. 2005
  5. pmc Maturation of active zone assembly by Drosophila Bruchpilot
    Wernher Fouquet
    Institute for Biology Genetics, Free University Berlin, Berlin, Germany
    J Cell Biol 186:129-45. 2009
  6. pmc Rab3 dynamically controls protein composition at active zones
    Ethan R Graf
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 64:663-77. 2009
  7. ncbi A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
    Amina Kurtovic
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 446:542-6. 2007
  8. pmc The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
    Dion K Dickman
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Science 326:1127-30. 2009
  9. ncbi Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 25:9069-79. 2005
  10. pmc A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila
    David Owald
    Department of Genetics, Institute for Biology, Freie Universitat Berlin, 14195 Berlin, Germany
    J Cell Biol 188:565-79. 2010

Research Grants

  1. Regulation of synaptic growth and plasticity in Drosophila
    KATHALEEN O CONNOR GILES; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications128 found, 100 shown here

  1. ncbi Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements
    Chunlai Wu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9557-66. 2005
    ....
  2. ncbi Distinct memory traces for two visual features in the Drosophila brain
    Gang Liu
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Nature 439:551-6. 2006
    ..These can be localized to two groups of neurons extending branches as parallel, horizontal strata in the fan-shaped body. The central location of this memory store is well suited to mediate translational invariance...
  3. ncbi Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila
    Dhananjay A Wagh
    Lehrstuhl für Genetik und Neurobiologie, Theodor Boveri Institut für Biowissenschaften, Am Hubland, D 97074 Wurzburg, Germany
    Neuron 49:833-44. 2006
    ..BRP shows homology to human AZ protein ELKS/CAST/ERC, which binds RIM1 in a complex with Bassoon and Munc13-1...
  4. ncbi Neural circuitry that governs Drosophila male courtship behavior
    Petra Stockinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:795-807. 2005
    ..This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent...
  5. pmc Maturation of active zone assembly by Drosophila Bruchpilot
    Wernher Fouquet
    Institute for Biology Genetics, Free University Berlin, Berlin, Germany
    J Cell Biol 186:129-45. 2009
    ..Recently, mutants of the Drosophila melanogaster ERC/CAST family protein Bruchpilot (BRP) were shown to lack dense projections (T-bars) and to suffer from Ca(2+) channel-..
  6. pmc Rab3 dynamically controls protein composition at active zones
    Ethan R Graf
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 64:663-77. 2009
    ..Late addition of Rab3 to mutant NMJs rapidly reverses this phenotype by recruiting Brp to sites previously lacking the protein, demonstrating that Rab3 can dynamically control the composition of the ..
  7. ncbi A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
    Amina Kurtovic
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 446:542-6. 2007
    ..Thus, activation of a single ORN class is both necessary and sufficient to mediate behavioural responses to the Drosophila sex pheromone cVA...
  8. pmc The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
    Dion K Dickman
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Science 326:1127-30. 2009
    ..Thus, dysbindin is essential for adaptive neural plasticity and may link altered homeostatic signaling with a complex neurological disease...
  9. ncbi Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe
    Rachel I Wilson
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 25:9069-79. 2005
    ....
  10. pmc A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila
    David Owald
    Department of Genetics, Institute for Biology, Freie Universitat Berlin, 14195 Berlin, Germany
    J Cell Biol 188:565-79. 2010
    ..At the Drosophila neuromuscular junction, the ELKS family member Bruchpilot (BRP) is essential for dense body formation and functional maturation of AZs...
  11. pmc Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling
    Alex C Koon
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Neurosci 14:190-9. 2011
    ..Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range...
  12. pmc Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity
    Zhengmei Mao
    Department of Molecular and Cellular Biology, Baylor College of Medicine Houston, TX, USA
    Front Neural Circuits 3:5. 2009
    ..Differences in functional response properties of these neurons suggest that they are involved in different behavioral processes...
  13. ncbi Neuropil pattern formation and regulation of cell adhesion molecules in Drosophila optic lobe development depend on synaptobrevin
    P R Hiesinger
    University of Freiburg, Institute of Biology III, D 79104 Freiburg, Germany
    J Neurosci 19:7548-56. 1999
    ..A possible causal link to fine-tuning processes that may include synaptic plasticity in the development of the Drosophila CNS is discussed...
  14. pmc Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog
    Bruno Marie
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158 2822, USA
    J Neurosci 30:8071-82. 2010
    ....
  15. ncbi Target neuron prespecification in the olfactory map of Drosophila
    G S Jefferis
    Neurosciences Program, Department of Biological Sciences, Stanford University, CA 94305, USA
    Nature 414:204-8. 2001
    ..These studies also imply a previously unanticipated role for precise dendritic targeting by postsynaptic neurons in determining connection specificity...
  16. ncbi Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth
    Bruno Marie
    Department of Biochemistry and Biophysics, 1550 4th Street, GDBS Fourth Floor North, University of California, San Francisco, 94143, USA
    Neuron 43:207-19. 2004
    ..We present a model in which Dap160 scaffolds both endocytic machinery and essential synaptic signaling systems to the periactive zone to coordinately control structural and functional synapse development...
  17. pmc Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling
    Bulent Ataman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neuron 57:705-18. 2008
    ..We propose that activation of the postsynaptic Wg pathway is required for the assembly of the postsynaptic apparatus, while activation of the presynaptic Wg pathway regulates cytoskeletal dynamics...
  18. pmc Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth
    Kate M O'Connor-Giles
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Neuron 58:507-18. 2008
    ..We propose that Nwk functions at the interface of endocytosis and BMP signaling to ensure proper synaptic growth by negatively regulating Tkv to set limits on this positive growth signal...
  19. pmc MicroRNA processing pathway regulates olfactory neuron morphogenesis
    Daniela Berdnik
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 18:1754-9. 2008
    ..However, Argonaute-1 and Argonaute-2 are dispensable for PN morphogenesis. Our findings suggest a role for the miRNA processing pathway in establishing wiring specificity in the nervous system...
  20. pmc Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release
    Tanja Wucherpfennig
    Max Planck Institut für molekulare Zellbiologie und Genetik, Dresden, Germany
    J Cell Biol 161:609-24. 2003
    ..Conversely, Rab5 overexpression increases the release efficacy. Therefore, the Rab5-dependent trafficking pathway plays an important role for synaptic performance...
  21. ncbi Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions
    Takaki Komiyama
    Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 7:819-25. 2004
    ..We propose that the precision of ORN axon targeting derives from both intrinsic transcriptional control and extensive axon-axon interactions...
  22. pmc Comprehensive maps of Drosophila higher olfactory centers: spatially segregated fruit and pheromone representation
    Gregory S X E Jefferis
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 128:1187-203. 2007
    ..Our results suggest that the LH is organized according to biological values of olfactory input...
  23. doi Drosophila RSK negatively regulates bouton number at the neuromuscular junction
    Matthias Fischer
    Institute for Clinical Neurobiology, University of Wurzburg, Würzburg 97078, Germany
    Dev Neurobiol 69:212-20. 2009
    ..These experiments provided evidence that RSK mediates its negative effect on bouton formation at the Drosophila NMJ by inhibition of ERK signaling...
  24. pmc PP2A and GSK-3beta act antagonistically to regulate active zone development
    Natasha M Viquez
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:11484-94. 2009
    ..When PP2A is inhibited presynaptically, many glutamate receptor clusters are unapposed to Bruchpilot (Brp), an active zone protein required for normal transmitter release...
  25. pmc Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction
    Misao E Higashi-Kovtun
    FM Kirby Center for Neurobiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 30:5253-68. 2010
    ..Thus, importin-beta11 function interacts with the BMP pathway to regulate a pool of pMAD that must be present at the presynapse for its proper development and function...
  26. doi Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory
    Stephan Knapek
    Max Planck Institut fur Neurobiologie, 82152 Martinsried, Germany
    J Neurosci 31:3453-8. 2011
    ..Here we report that Bruchpilot (Brp), a ubiquitous presynaptic active zone protein, is required for olfactory memory...
  27. ncbi Three-dimensional reconstruction of the antennal lobe in Drosophila melanogaster
    P P Laissue
    Institute of Zoology and Program in Neuroscience, University of Fribourg, Switzerland
    J Comp Neurol 405:543-52. 1999
    ..melanogaster, based on confocal microscopic analysis of glomeruli stained with the neuropil-specific monoclonal antibody nc82. The analysis of confocal stacks allowed us to identify glomeruli according to the criteria shape, size, ..
  28. ncbi Altered representation of the spatial code for odors after olfactory classical conditioning; memory trace formation by synaptic recruitment
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 USA
    Neuron 42:437-49. 2004
    ..The rapid recruitment by conditioning of new synapses into the representation of sensory information may be a general mechanism underlying many forms of short-term memory...
  29. ncbi Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:858-63. 2005
    ..Postsynaptic Ca2+ influx also stimulates local synaptic differentiation and growth through Syt 4-mediated retrograde signals in a synapse-specific manner...
  30. ncbi Postsynaptic mad signaling at the Drosophila neuromuscular junction
    Veronica Dudu
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Biol 16:625-35. 2006
    ..There is evidence that a retrograde, presynaptic transforming growth factor-beta (TGF-beta) signaling event regulates synapse development and function in Drosophila...
  31. pmc Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP
    Bulent Ataman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Proc Natl Acad Sci U S A 103:7841-6. 2006
    ..These results provide a mechanism by which DFz2 is transported from the postsynaptic membrane to the postsynaptic nucleus during synapse formation and implicate dGRIP as an essential molecule in the transport of this signal...
  32. ncbi Non-NMDA-type glutamate receptors are essential for maturation but not for initial assembly of synapses at Drosophila neuromuscular junctions
    Andreas Schmid
    European Neuroscience Institute Göttingen, 37077 Gottingen, Germany
    J Neurosci 26:11267-77. 2006
    ..Thus, our data suggest that incorporation of non-NMDA-type glutamate receptors and likely their protein-protein interactions with additional PSD components triggers a conversion from an initial to a mature stage of PSD assembly...
  33. ncbi Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection neurons
    Takaki Komiyama
    Department of Biological Sciences and Neurosciences Program, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 128:399-410. 2007
    ..Thus, graded expression of Sema-1a contributes to connection specificity from ORNs to PNs and then to higher brain centers, ensuring proper representation of olfactory information in the brain...
  34. ncbi A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport
    Eunju Pack-Chung
    Program in Neurobiology, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 10:980-9. 2007
    ..Our data thus indicate that Imac transports components required for synaptic maturation and provide insight into presynaptic maturation as a process that can be differentiated from axon outgrowth and targeting...
  35. pmc Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission
    Jingjun Li
    Curriculum in Neurobiology, Department of Cell and Molecular Physiology, UNC Neuroscience Center, Neurodevelopmental Disorders Research Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7545, USA
    Neuron 55:741-55. 2007
    ..Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments...
  36. ncbi Chronic and acute alterations in the functional levels of Frequenins 1 and 2 reveal their roles in synaptic transmission and axon terminal morphology
    Jesús Romero-Pozuelo
    Instituto Cajal, CSIC, Ave Dr Arce 37, Madrid 28002, Spain
    Eur J Neurosci 26:2428-43. 2007
    ..We conclude that Frqs have two distinct functions: one in neurotransmission, regulating the probability of release per synapse, and another in axonal growth and bouton formation...
  37. pmc Unc-51 controls active zone density and protein composition by downregulating ERK signaling
    Yogesh P Wairkar
    Department of Developmental Biology, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 29:517-28. 2009
    ..The Unc-51-dependent inhibition of ERK activity provides a potential mechanism for synapse-specific control of active zone protein composition and release probability...
  38. ncbi The Drosophila standard brain
    Karlheinz Rein
    Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, 97074 Wurzburg, Germany
    Curr Biol 12:227-31. 2002
    ..We now provide a representative standard for the brain of D. melanogaster wild-type with means and variances for several aspects of its shape. Its application to volumetry, mutants, and gene expression patterns is demonstrated...
  39. ncbi Diverse functions of N-cadherin in dendritic and axonal terminal arborization of olfactory projection neurons
    Haitao Zhu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 42:63-75. 2004
    ..Although the N-cadherin locus potentially encodes eight alternatively spliced isoforms, transgenic expression of one isoform is sufficient to rescue all phenotypes...
  40. ncbi Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles
    Kyle E Miller
    Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 15:684-9. 2005
    ..It suggests the synaptic strength and morphology defects linked to Liprin-alpha may in part be due to a failure in the delivery of synaptic-vesicle precursors...
  41. ncbi The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain
    Andrea Mahr
    Max Planck Institut fur Entwicklungsbiologie, Abt III Genetik, Spemannstr 35, 72076 Tubingen, Germany
    Gene Expr Patterns 6:299-309. 2006
    ..Given that vesicular glutamate transporters are essential for the uptake of the neurotransmitter glutamate into synaptic vesicles these tools provide a means to test gene function in these functionally important neurons...
  42. ncbi The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction
    Natasha M Viquez
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:9293-303. 2006
    ..Hence, wrd promotes the function of PP2A and is required for normal cytoskeletal organization, synaptic growth, and synaptic function at the Drosophila NMJ...
  43. ncbi A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth
    Sarah Huntwork
    The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Building 46, Room 3243, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 10:1235-7. 2007
    ....
  44. doi Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila
    Robert Lichtneckert
    Biozentrum, University of Basel, Basel, Switzerland
    Development 135:2415-24. 2008
    ..The finding that Drosophila ems, like its murine homologs Emx1/2, is required for the formation of olfactory circuitry implies that conserved genetic programs control olfactory system development in insects and mammals...
  45. pmc Negative regulation of active zone assembly by a newly identified SR protein kinase
    Ervin L Johnson
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA
    PLoS Biol 7:e1000193. 2009
    ..The SRPK79D protein colocalizes with the T-bar-associated protein Bruchpilot (Brp) in both the axon and synapse...
  46. pmc Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton
    Catherine M Massaro
    Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 187:101-17. 2009
    ....
  47. pmc The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis
    Christopher J Potter
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Cell 141:536-48. 2010
    ..The Q system can be expanded to other uses in Drosophila and to any organism conducive to transgenesis...
  48. pmc Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction
    Rebecca E James
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Development 138:3273-86. 2011
    ..We present a model whereby this inhibition permits the muscle-derived Gbb pool to predominate at the NMJ, thus establishing the retrograde directionality of the pro-growth BMP pathway...
  49. pmc A neuropeptide signaling pathway regulates synaptic growth in Drosophila
    Xu Chen
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    J Cell Biol 196:529-43. 2012
    ..Moreover, because the cAMP-PKA-CREB pathway is required for structural synaptic plasticity in learning and memory, DSK/CCKLR signaling may also contribute to these mechanisms...
  50. pmc RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool
    Martin Muller
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158 0822, USA
    J Neurosci 32:16574-85. 2012
    ..By extension, homeostatic plasticity appears to require two genetically separable processes, the enhancement of presynaptic calcium influx and a RIM-dependent modulation of the RRP...
  51. ncbi Smell and taste perception in Drosophila melanogaster larva: toxin expression studies in chemosensory neurons
    G Heimbeck
    Institute of Zoology and Program in Neuroscience, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Neurosci 19:6599-609. 1999
    ..Hence, a subset of neurons from the TO builds an anatomical entity with projections from the DO. Our results suggest that the AMC contains both olfactory and gustatory sensilla, and that the DO is the main olfactory organ in larvae...
  52. ncbi Adult-like complexity of the larval antennal lobe of D. melanogaster despite markedly low numbers of odorant receptor neurons
    François Python
    Department of Biology and Program in Neuroscience, University of Fribourg, CH 1700 Fribourg, Switzerland
    J Comp Neurol 445:374-87. 2002
    ....
  53. ncbi Development of the Drosophila mushroom bodies: elaboration, remodeling and spatial organization of dendrites in the calyx
    Sijun Zhu
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, IL 61801, USA
    Development 130:2603-10. 2003
    ..Taken together, subregional differences exist in the adult Drosophila MB calyx, where processing and integration of distinct types of sensory information begin...
  54. pmc The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila
    P Robin Hiesinger
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 121:607-20. 2005
    ..Our data suggest that Vha100-1 functions downstream of SNAREs in synaptic vesicle fusion...
  55. ncbi Presynaptic spectrin is essential for synapse stabilization
    Jan Pielage
    Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Curr Biol 15:918-28. 2005
    ..Precise neural circuitry is established and maintained through a regulated balance of synapse stabilization and disassembly. Currently, little is known about the molecular mechanisms that specify synapse stability versus disassembly...
  56. ncbi Glomerular maps without cellular redundancy at successive levels of the Drosophila larval olfactory circuit
    Ariane Ramaekers
    Department of Biology, University of Fribourg, Chemin du Musee 10, CH 1700 Fribourg, Switzerland
    Curr Biol 15:982-92. 2005
    ..Does this suggest that the larval olfactory system is built according to a different design than its adult counterpart, or is it just a miniature version thereof?..
  57. ncbi Glutamate receptor dynamics organizing synapse formation in vivo
    Tobias M Rasse
    European Neuroscience Institute Göttingen, Max Planck Society, Waldweg 33, D 37073 Gottingen, Germany
    Nat Neurosci 8:898-905. 2005
    ....
  58. ncbi Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila
    Shovon I Ashraf
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 124:191-205. 2006
    ..Therefore, we propose that degradative control of the RISC pathway underlies the pattern of synaptic protein synthesis associated with a stable memory...
  59. ncbi Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe
    Haitao Zhu
    Howard Hughes Medical Institute and Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 9:349-55. 2006
    ..This observation provides evidence for a pre- and postsynaptic matching mechanism independent of precise glomerular positioning...
  60. ncbi Wiring stability of the adult Drosophila olfactory circuit after lesion
    Daniela Berdnik
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    J Neurosci 26:3367-76. 2006
    ..We conclude that, although adult olfactory neurons can undergo plastic changes in response to the loss of competition, the olfactory circuit overall is extremely stable in preserving segregated information channels in this discrete map...
  61. ncbi Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
    Robert J Kittel
    European Neuroscience Institute Göttingen, Grisebachstrasse 5, 37077 Gottingen, Germany
    Science 312:1051-4. 2006
    ..The Drosophila coiled-coil domain protein Bruchpilot (BRP) was observed in donut-shaped structures centered at active zones of neuromuscular synapses by using subdiffraction ..
  62. ncbi Highwire restrains synaptic growth by attenuating a MAP kinase signal
    Catherine A Collins
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Neuron 51:57-69. 2006
    ..In addition to controlling synaptic growth, Highwire promotes synaptic function through a separate pathway that does not require wallenda...
  63. ncbi Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity
    Sijun Zhu
    Department of Cell and Developmental Biology, University of Illinois, Urbana, 61801, USA
    Cell 127:409-22. 2006
    ..Taken together, we suggest that a temporal gradient of Chinmo (Chinmo(high) --> Chinmo(low)) helps specify distinct birth order-dependent cell fates in an extended neuronal lineage...
  64. pmc A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 175:491-503. 2006
    ..We propose a model in which a postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged...
  65. ncbi Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions
    Lora B Sweeney
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Neuron 53:185-200. 2007
    ..We propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arriving ORN axons constrain the target choices of late-arriving axons...
  66. ncbi Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster
    Robert Lichtneckert
    Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 134:1291-300. 2007
    ....
  67. ncbi Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila
    Xiankun Zeng
    Department of Genetics and Developmental Biology, Genetics Research Center, Southeast University Medical School, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China
    FEBS Lett 581:2509-16. 2007
    ..The synapse number is decreased in central nervous system in Neurexin-1 null mutants. In addition, Neurexin-1 null mutants exhibit associative learning defect in larvae...
  68. pmc In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2
    Hiroshi Kohsaka
    Department of Physics, Graduate School of Science, Graduate School of Frontier Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Cell Biol 179:1289-300. 2007
    ..We propose that Fas2 mediates trans-synaptic adhesion, which contributes to postsynaptic molecular assembly at the onset of synaptogenesis...
  69. doi The Drosophila pheromone cVA activates a sexually dimorphic neural circuit
    Sandeep Robert Datta
    Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 452:473-7. 2008
    ..The observation that cVA activates a sexually dimorphic circuit in the protocerebrum suggests a mechanism by which a single pheromone can elicit different behaviours in males and in females...
  70. doi Neuronal assemblies of the Drosophila mushroom body
    Nobuaki K Tanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    J Comp Neurol 508:711-55. 2008
    ..Structural differences between lobes are also discussed...
  71. pmc A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesion
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158 2822, USA
    Neuron 58:195-209. 2008
    ..We propose that a presynaptic Ank2-L lattice links synaptic membrane proteins and spectrin to the underlying microtubule cytoskeleton to organize and stabilize the presynaptic terminal...
  72. doi Drosophila ankyrin 2 is required for synaptic stability
    Iris Koch
    Max Planck Institute for Developmental Biology, Department III Genetics, Spemannstrasse 35, 72076 Tubingen, Germany
    Neuron 58:210-22. 2008
    ..Interestingly, Ank2 functions downstream of spectrin in the anchorage of synaptic microtubules, providing the cytoskeletal scaffold that is essential for synaptic stability...
  73. doi Activity-dependent site-specific changes of glutamate receptor composition in vivo
    Andreas Schmid
    Institute for Clinical Neurobiology, Medical Faculty, University of Wurzburg, Zinklesweg 10, 97080 Wurzburg, Germany
    Nat Neurosci 11:659-66. 2008
    ..Thus, we show that an activity-dependent, site-specific control of GluR composition can contribute to match pre- and postsynaptic assembly...
  74. pmc A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism
    Anuradha Ratnaparkhi
    Department of Neurology, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 3:e2334. 2008
    ..This new fly model of ALS, with its robust pathological phenotypes, should for the first time allow the power of unbiased screens in Drosophila to be applied to study of motor neuron diseases...
  75. doi Clonal analysis of Drosophila antennal lobe neurons: diverse neuronal architectures in the lateral neuroblast lineage
    Sen Lin Lai
    Department of Neurobiology, University of Massachusetts, Worcester, MA 01605, USA
    Development 135:2883-93. 2008
    ..These systematic cell lineage analyses have not only filled gaps in the olfactory map, but have also exemplified additional strategies used in the brain to increase neuronal diversity...
  76. pmc Photoreceptor neurons find new synaptic targets when misdirected by overexpressing runt in Drosophila
    Tara N Edwards
    Department of Biology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurosci 29:828-41. 2009
    ..This uniformity indicates the cell-autonomous determination of the architecture of its synaptic organelles by the presynaptic photoreceptor terminal...
  77. pmc A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels
    C Andrew Frank
    Department of Biochemistry and Biophysics, 1550 4th Street, Rock Hall 4th Floor North, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 61:556-69. 2009
    ..Based on these data, we propose that Ephexin/Cdc42 couples synaptic Eph signaling to the modulation of presynaptic CaV2.1 channels during the homeostatic enhancement of presynaptic release...
  78. pmc Twin-spot MARCM to reveal the developmental origin and identity of neurons
    Hung Hsiang Yu
    Department of Neurobiology, University of Massachusetts, Worcester, USA
    Nat Neurosci 12:947-53. 2009
    ..In sum, twin-spot MARCM can reveal the developmental origins of neurons and the mechanisms that underlie cell fate...
  79. pmc Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris
    Yuly Fuentes-Medel
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 7:e1000184. 2009
    ....
  80. pmc Writing memories with light-addressable reinforcement circuitry
    Adam Claridge-Chang
    Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Cell 139:405-15. 2009
    ..The delineation of core reinforcement circuitry is an essential first step in dissecting the neural mechanisms that compute and represent valuations, store associations, and guide actions...
  81. pmc Bruchpilot in ribbon-like axonal agglomerates, behavioral defects, and early death in SRPK79D kinase mutants of Drosophila
    Vanessa Nieratschker
    Department of Genetics and Neurobiology, Julius Maximilians University, Wurzburg, Germany
    PLoS Genet 5:e1000700. 2009
    ..In Drosophila the Bruchpilot (BRP) protein is associated with T-shaped ribbons ("T-bars") at presynaptic active zones (AZs)...
  82. pmc Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map
    Weizhe Hong
    Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, California, USA
    Nat Neurosci 12:1542-50. 2009
    ..The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation...
  83. doi The shaping of male courtship posture by lateralized gustatory inputs to male-specific interneurons
    Masayuki Koganezawa
    Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai 980 8578, Japan
    Curr Biol 20:1-8. 2010
    ..These observations prompted the postulation that the proper wing display by courting males of D. melanogaster does not require sensory inputs...
  84. pmc Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe
    Ya Hui Chou
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, USA
    Nat Neurosci 13:439-49. 2010
    ..Our results reveal an unexpected degree of complexity and individual variation in an invertebrate neural circuit, a result that creates challenges for solving the Drosophila connectome...
  85. doi Structure of the adult central complex in Drosophila: organization of distinct neuronal subsets
    J M Young
    Institute for Adaptive and Neural Computation, University of Edinburgh, Edinburgh, UK
    J Comp Neurol 518:1500-24. 2010
    ..Small-field neurons were observed in clearly organized layers. This study provides a novel insight into CX structure and connectivity and provides a set of characterized enhancer trap lines that will be valuable for future study...
  86. pmc Development-based compartmentalization of the Drosophila central brain
    Wayne Pereanu
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 518:2996-3023. 2010
    ....
  87. doi Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions
    Daniel Banovic
    University of Munster, Institute for Neurobiology, Munster, Germany
    Neuron 66:724-38. 2010
    ..Instead, other signaling components are likely involved in DNlg1 transsynaptic functions, with essential interactions organized by the DNlg1 extracellular domain but also by the cytoplasmic domain...
  88. doi Two pools of vesicles associated with the presynaptic cytosolic projection in Drosophila neuromuscular junctions
    Wei Jiao
    Department of Neuroscience, DBRM, Karolinska Institutet, 17177 Stockholm, Sweden
    J Struct Biol 172:389-94. 2010
    ..This suggests that SVs associated with the PCP loose their connections with other vesicles in the cluster during translocation to the site of fusion...
  89. doi Neural architecture of the primary gustatory center of Drosophila melanogaster visualized with GAL4 and LexA enhancer-trap systems
    Takaaki Miyazaki
    Institute of Molecular and Cellular Biosciences IMCB, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Comp Neurol 518:4147-81. 2010
    ....
  90. doi Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning
    Takuya Tamura
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Neurosci 30:14091-101. 2010
    ..Collectively, these findings identify dPQBP1 as a novel gene regulating learning acquisition at PNs...
  91. pmc The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling
    Minyeop Nahm
    Interdisplinary Program in Brain Science, Seoul National University, Seoul, Republic of Korea
    J Cell Biol 191:661-75. 2010
    ..Importantly, dRich increases Gbb release and elevates presynaptic phosphorylated Mad levels. We propose that dRich coordinates the Gbb-dependent modulation of synaptic growth and function with postsynaptic development...
  92. pmc Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila
    Laura J J Nicolaï
    Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, Flanders Institute of Biotechnology VIB, 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 107:20553-8. 2010
    ..We show that DenMark is a powerful tool for revealing novel aspects of the neuroanatomy of developing dendrites, identifying previously unknown dendritic arbors, and elucidating neuronal connectivity...
  93. pmc Drosophila Importin-α2 is involved in synapse, axon and muscle development
    Timothy J Mosca
    F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, United States of America
    PLoS ONE 5:e15223. 2010
    ..Thus, Importin-α2 is needed for some processes in the development of both the nervous system and the larval musculature...
  94. pmc The dopaminergic system in the aging brain of Drosophila
    Katherine E White
    Department of Neuroscience, Institute of Psychiatry, Medical Research Council Centre for Neurodegeneration Research, King s College London London, UK
    Front Neurosci 4:205. 2010
    ..Taken together, our data establish baseline parameters in Drosophila for the study of Parkinson's disease as well as other disorders affecting DA neurons and movement control...
  95. pmc Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1
    Ian King
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 31:1139-48. 2011
    ....
  96. pmc Glial-derived prodegenerative signaling in the Drosophila neuromuscular system
    Lani C Keller
    Department of Biochemistry and Biophysics, University of California, San Francisco, 1550 4th Street, Rock Hall 4th Floor North, San Francisco, CA 94143, USA
    Neuron 72:760-75. 2011
    ....
  97. pmc Layered reward signalling through octopamine and dopamine in Drosophila
    Christopher J Burke
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 492:433-7. 2012
    ..In addition, they reconcile previous findings with octopamine and dopamine and suggest that reinforcement systems in flies are more similar to mammals than previously thought...
  98. pmc Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model
    Petra Füger
    Junior Research Group Synaptic Plasticity, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    PLoS Genet 8:e1003066. 2012
    ....
  99. ncbi Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam
    Thomas Hummel
    Howard Hughes Medical Institute, Department of Biological Chemistry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 37:221-31. 2003
    ..Multiple forms of Dscam RNA were detected in the developing antenna, and Dscam protein was localized to developing ORN axons. We propose a role for Dscam protein diversity in regulating ORN target specificity...
  100. ncbi Afferent induction of olfactory glomeruli requires N-cadherin
    Thomas Hummel
    Howard Hughes Medical Institute, Department of Biological Chemistry, Geffen School of Medicine, Molecular Biology Institute, Box 951662, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Neuron 42:77-88. 2004
    ..We propose that N-cad, a homophilic cell adhesion molecule, acts in a permissive fashion to promote subclass-specific sorting of ORN axon terminals into protoglomeruli...
  101. pmc Heterogeneity in synaptic transmission along a Drosophila larval motor axon
    Giovanna Guerrero
    Department of Molecular and Cell Biology, 279 Life Sciences Addition, University of California Berkeley, Berkeley, California 94720, USA
    Nat Neurosci 8:1188-96. 2005
    ..The results suggest that transmission strength is mainly determined presynaptically at the level of individual boutons, possibly by one or more factors existing in a gradient...

Research Grants1

  1. Regulation of synaptic growth and plasticity in Drosophila
    KATHALEEN O CONNOR GILES; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..