brm

Summary

Gene Symbol: brm
Description: brahma
Alias: BRD, BRM, Brahma, Brm, Brm @ Kto, CG18438, CG5942, Dmel\CG5942, E(E2F)3A, dBRM, dSMARCA4, dSNF2, l(3)72Aa, CG5942 gene product from transcript CG5942-RD, CG5942-PA, CG5942-PB, CG5942-PC, CG5942-PD, CG5942-PE, CG5942-PF, brm-PA, brm-PB, brm-PC, brm-PD, brm-PE, brm-PF, complementation group 3.5
Species: fruit fly

Top Publications

  1. ncbi brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2
    J W Tamkun
    Department of Biology, University of California, Santa Cruz 95064
    Cell 68:561-72. 1992
  2. pmc Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila
    J A Kennison
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 85:8136-40. 1988
  3. ncbi The role of brahma and related proteins in transcription and development
    J W Tamkun
    Department of Biology, University of California, Santa Cruz 95064, USA
    Curr Opin Genet Dev 5:473-7. 1995
  4. ncbi Genetic interactions and dosage effects of Polycomb group genes of Drosophila
    R B Campbell
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Mol Gen Genet 246:291-300. 1995
  5. pmc Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SWI2
    L K Elfring
    Department of Biology, University of California, Santa Cruz 95064
    Mol Cell Biol 14:2225-34. 1994
  6. pmc Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb region
    J A Kassis
    Laboratory of Developmental Biology, Food and Drug Administration, Bethesda, Maryland 20892
    Genetics 136:1025-38. 1994
  7. ncbi ISWI, a member of the SWI2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor
    T Tsukiyama
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Cell 83:1021-6. 1995
  8. pmc The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger
    N Tripoulas
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 143:913-28. 1996
  9. pmc A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex
    K Hagstrom
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Genetics 146:1365-80. 1997
  10. ncbi Polycomb and trithorax group proteins mediate the function of a chromatin insulator
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cell 92:511-21. 1998

Research Grants

  1. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
  2. Fourth Symposium Biology Vertebrate Sex Determination
    Blanche Capel; Fiscal Year: 2006
  3. Organ-specific Mechanisms of Vascular Development
    Blanche Capel; Fiscal Year: 2007
  4. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. ncbi brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2
    J W Tamkun
    Department of Biology, University of California, Santa Cruz 95064
    Cell 68:561-72. 1992
    The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila...
  2. pmc Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila
    J A Kennison
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 85:8136-40. 1988
    ..e., Sex combs reduced (Scr), Brista (Ba), trithorax (trx), Polycomb (Pc), Polycomblike (Pcl), and Sex comb on midleg (Scm)]. Mutations in several of the additional loci identified here have also been shown to have homoeotic phenotypes...
  3. ncbi The role of brahma and related proteins in transcription and development
    J W Tamkun
    Department of Biology, University of California, Santa Cruz 95064, USA
    Curr Opin Genet Dev 5:473-7. 1995
    ..During the past year, studies of a trithorax group member, brahma, and related yeast and human proteins have suggested that they are components of huge complexes that assist DNA-..
  4. ncbi Genetic interactions and dosage effects of Polycomb group genes of Drosophila
    R B Campbell
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Mol Gen Genet 246:291-300. 1995
    ..Flies with increasing doses of esc+ exhibit anterior transformations, but these are not enhanced by mutations in trithorax group genes. The results are discussed with respect to current models of Pc group function...
  5. pmc Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SWI2
    L K Elfring
    Department of Biology, University of California, Santa Cruz 95064
    Mol Cell Biol 14:2225-34. 1994
    The Drosophila brahma (brm) gene encodes an activator of homeotic genes that is highly related to the yeast transcriptional activator SWI2 (SNF2), a potential helicase...
  6. pmc Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb region
    J A Kassis
    Laboratory of Developmental Biology, Food and Drug Administration, Bethesda, Maryland 20892
    Genetics 136:1025-38. 1994
    ..I propose that engrailed PS sites normally act to promote interactions between distantly located engrailed regulatory sites and the engrailed promoter...
  7. ncbi ISWI, a member of the SWI2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor
    T Tsukiyama
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Cell 83:1021-6. 1995
    ..The convergence of biochemical and genetic studies on ISWI and SWI2/SNF2 underscores these ATPases and their close relatives as key components of independent systems for chromatin remodeling...
  8. pmc The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger
    N Tripoulas
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 143:913-28. 1996
    ..The chromosomal localization of ASH1 implies that it functions at the transcriptional level to maintain the expression pattern of homeotic selector genes...
  9. pmc A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex
    K Hagstrom
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Genetics 146:1365-80. 1997
    ..The iab-7 PRE silencer is contained within a 0.8-kb fragment that spans a nuclease hypersensitive site, and silencing appears to depend on the chromatin remodeling protein, the GAGA factor...
  10. ncbi Polycomb and trithorax group proteins mediate the function of a chromatin insulator
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cell 92:511-21. 1998
    ..The results suggest a model in which PcG and TrxG proteins regulate insulator function by establishing higher order domains of chromatin organization required for the assembly of functional insulators at the nuclear matrix...
  11. ncbi Shaping animal body plans in development and evolution by modulation of Hox expression patterns
    G Gellon
    Department of Biology, Yale University, New Haven, CT, USA
    Bioessays 20:116-25. 1998
    ....
  12. pmc The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster
    M A Crosby
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 19:1159-70. 1999
    ..In vitro, MOR can bind to itself and it interacts with Brahma (BRM), an SWI2-SNF2 homolog, with which it is associated in embryonic nuclear extracts...
  13. ncbi The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription
    M Vazquez
    Laboratory of Molecular Genetics, National Institute of Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 126:733-42. 1999
    The trithorax group gene brahma (brm) encodes the ATPase subunit of a chromatin-remodeling complex involved in homeotic gene regulation...
  14. ncbi The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity
    G Daubresse
    Department of Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Development 126:1175-87. 1999
    ..The Kismet proteins contain a domain conserved in the trithorax group protein Brahma and related chromatin-remodeling factors, providing further evidence that alterations in chromatin structure are ..
  15. ncbi Stabilization of chromatin structure by PRC1, a Polycomb complex
    Z Shao
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Cell 98:37-46. 1999
    ..Several different types of repressive complexes, including deacetylases, interact with histone tails. In contrast, PRC1 was active on nucleosomal arrays formed with tailless histones...
  16. ncbi Epigenetic inheritance of active chromatin after removal of the main transactivator
    G Cavalli
    Zentrum für Molekulare Biologie ZMBH, Universität of Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Science 286:955-8. 1999
    ..This feature may allow epigenetic maintenance of active states of developmental genes after decay of their early embryonic regulators...
  17. pmc Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes
    R T Collins
    Skirball Institute for Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 550 First Avenue, New York, NY 10016, USA
    EMBO J 18:7029-40. 1999
    ..We present genetic and biochemical evidence that Osa is a component of the Brahma complex, the Drosophila homolog of SWI/SNF...
  18. ncbi The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo
    R Deuring
    Department of Biology, University of California, Santa Cruz 95064, USA
    Mol Cell 5:355-65. 2000
    ..These findings reveal novel functions for the ISWI ATPase and underscore its importance in chromatin remodeling in vivo...
  19. ncbi The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes
    M L Ruhf
    UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, France
    Development 128:1429-41. 2001
    ..Altogether, the data lead us to propose that domino acts as a repressor by interfering with chromatin structure. This activity is likely to be performed as a subunit of a chromatin-remodeling complex...
  20. ncbi Chromatin remodeling enzymes: who's on first?
    C J Fry
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 301, Worcester, MA 01605, USA
    Curr Biol 11:R185-97. 2001
    ..Here we review recent developments concerning the role of chromatin remodeling enzymes in gene regulation, and propose several models to explain how different chromatin remodeling activities can be functionally coupled...
  21. pmc Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins
    F Hirose
    Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
    Mol Cell Biol 21:7231-42. 2001
    ..of some of the trithorax group genes involved in determining chromatin structure or chromatin remodeling (brahma, moira, and osa) significantly suppressed and that reduction of Distal-less enhanced the DREF-induced rough eye ..
  22. ncbi corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae
    A Lopez
    Equipe Developpement et Evolution, Biologie du Développement, UMR 7622 CNRS, Universite Pierre et Marie Curie, 9, quai Saint Bernard, 75252 Paris Cedex 05, France
    Mol Genet Genomics 266:572-83. 2001
    ..Our results provide evidence that corto maintains the anterior border of Ubx expression in third-instar larvae. We suggest that this regulation is accomplished through an interaction with the products of the Pc-G and trx-G genes...
  23. pmc The Drosophila BRM complex facilitates global transcription by RNA polymerase II
    Jennifer A Armstrong
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    EMBO J 21:5245-54. 2002
    Drosophila brahma (brm) encodes the ATPase subunit of a 2 MDa complex that is related to yeast SWI/SNF and other chromatin-remodeling complexes...
  24. ncbi The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein
    Luis Gutierrez
    Departamento de Fisiologia Molecular y Genetica del Desarrollo, Instituto de Biotecnologia, UNAM, Cuernavaca, Morelos 62250, Mexico
    Development 130:343-54. 2003
    The trithorax group genes are required for positive regulation of homeotic gene function. The trithorax group gene brahma encodes a SWI2/SNF2 family ATPase that is a catalytic subunit of the Brm chromatin-remodeling complex...
  25. pmc The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complex
    Daniel R Marenda
    Department of Biology, Syracuse University, New York 13244 1270, USA
    Mol Cell Biol 23:289-305. 2003
    The Drosophila melanogaster Brahma (Brm) complex, a counterpart of the Saccharomyces cerevisiae SWI/SNF ATP-dependent chromatin remodeling complex, is important for proper development by maintaining specific gene expression patterns...
  26. pmc Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by Osa
    Pascal Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch Cedex, Strasbourg, France
    Genes Dev 17:591-6. 2003
    ..We show here that this communication is regulated by Osa, which is recruited by Pannier and Chip. Osa belongs to Brahma chromatin remodeling complexes and we show that Osa negatively regulates ac/sc...
  27. pmc Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes
    Lisette Mohrmann
    Gene Regulation Laboratory, Centre for Biomedical Genetics, Department of Molecular and Cell Biology, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Mol Cell Biol 24:3077-88. 2004
    ..Therefore, it was puzzling that Drosophila appeared to contain only a single SWI/SNF-type remodeler, the Brahma (BRM) complex...
  28. ncbi Osa modulates the expression of Apterous target genes in the Drosophila wing
    Marco Milan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mech Dev 121:491-7. 2004
    ..We have found Osa, a member of the Brahma chromatin-remodeling complex, as a positive modulator of Apterous activity in the Drosophila wing...
  29. pmc SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex
    Claudia B Zraly
    Oncology Institute, Cardinal Bernardin Cancer Center, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153, USA
    Genetics 168:199-214. 2004
    SNR1 is an essential subunit of the Drosophila Brahma (Brm) ATP-dependent chromatin remodeling complex, with counterparts in yeast (SNF5) and mammals (INI1)...
  30. ncbi The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II
    Shrividhya Srinivasan
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Development 132:1623-35. 2005
    ..By contrast, the loss of KIS-L function does not affect the binding of PC to chromatin or the recruitment of Pol II to promoters. These data suggest that KIS-L facilitates an early step in transcriptional elongation by Pol II...
  31. pmc Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control
    Yuri M Moshkin
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 27:651-61. 2007
    ..The two complexes share the same core subunits, including the BRM ATPase, but differ in a few signature subunits: OSA defines BAP, whereas Polybromo (PB) and BAP170 specify PBAP...
  32. pmc Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in Drosophila
    M Soledad Ivaldi
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genes Dev 21:2818-31. 2007
    ..present evidence suggesting that JIl-1-mediated H3S10 phosphorylation is dependent on chromatin remodeling by the brahma complex and is required during early transcription elongation to release RNA polymerase II (Pol II) from promoter-..
  33. pmc The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complex
    Gillian E Chalkley
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 28:2920-9. 2008
    ..Both complexes share seven core subunits, including the Brahma ATPase, but differ in a few signature subunits; POLYBROMO and BAP170 specify PBAP, whereas OSA defines BAP...
  34. pmc Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II
    Shrividhya Srinivasan
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA
    PLoS Genet 4:e1000217. 2008
    ..Our findings suggest that KIS-L promotes early elongation and counteracts Polycomb group repression by recruiting the ASH1 and TRX histone methyltransferases to chromatin...
  35. doi Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing
    Ana Terriente-Félix
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Dev Biol 329:350-61. 2009
    ..In Drosophila there is only one SWI/SNF protein, named Brahma, which forms the catalytic subunit of two complexes composed of different proteins...
  36. pmc Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex
    Nadezhda E Vorobyeva
    Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Vavilov Street 34 5, Moscow, 119334 Russia
    Proc Natl Acad Sci U S A 106:11049-54. 2009
    ..we have shown the existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, named BTFly (Brahma and TFIID in one assembly)...
  37. ncbi The novel regulator of metazoan development SAYP organizes a nuclear coactivator supercomplex
    Nadezhda E Vorobyeva
    Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Cell Cycle 8:2152-6. 2009
    ..SAYP function is related to the conserved domain SAY, which assembles a nuclear supercomplex BTFly consisting of Brahma and TFIID coactivators...
  38. doi Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila
    Anabel Herr
    Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Dev Biol 344:36-51. 2010
    ..In Xenopus, Geminin acts to antagonize the Brahma (Brm) chromatin-remodeling protein, Brg1, during neural differentiation...
  39. pmc 14-3-3 mediates histone cross-talk during transcription elongation in Drosophila
    Caline S Karam
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Genet 6:e1000975. 2010
    ..These results suggest that 14-3-3 proteins mediate cross-talk between histone phosphorylation and acetylation at a critical step in transcription elongation...
  40. ncbi SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation
    Nadezhda E Vorobyeva
    Russian Academy of Sciences, Moscow, Russia
    Cell Cycle 10:1821-7. 2011
    ..SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex...
  41. doi Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila
    Daniel Kirilly
    Temasek Life Sciences Laboratory and Department of Biological Sciences, 1 Research Link, National University of Singapore, Singapore 117604
    Neuron 72:86-100. 2011
    ..Here, we analyzed 81 epigenetic factors, from which a Brahma (Brm)-containing chromatin remodeler and a histone acetyltransferase CREB-binding protein (CBP) were identified ..
  42. pmc SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster
    Johan Waldholm
    Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
    BMC Mol Biol 12:46. 2011
    ..SWI/SNF complexes contain one subunit with ATPase activity, which in Drosophila melanogaster is called Brahma (Brm)...
  43. pmc Remodelers organize cellular chromatin by counteracting intrinsic histone-DNA sequence preferences in a class-specific manner
    Yuri M Moshkin
    Department of Biochemistry and Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Mol Cell Biol 32:675-88. 2012
    ..We conclude that the cellular nucleosome landscape is the result of the balance between DNA sequence-driven nucleosome placement and active nucleosome repositioning by remodelers and the transcription machinery...
  44. pmc Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27
    Feng Tie
    Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA
    Mol Cell Biol 32:2323-34. 2012
    ..on other TrxG proteins, including the histone H3K27-specific demethylase UTX and the chromatin-remodeling ATPase Brahma (BRM)...
  45. doi The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions
    Takahiro Nakayama
    Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Development 139:4582-90. 2012
    ..3 replacement at chromatin boundaries. Here, we report that GAGA factor associates with the Polybromo-associated Brm (PBAP) remodeling complex, which consists of many Trithorax group proteins, and recruits this complex to chromatin ..
  46. pmc Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Cell Rep 3:309-18. 2013
    ..Coimmunoprecipitation and mass spectrometry identify GAGA factor (GAF), the Brahma complex, and the Mediator complex as Yorkie-associated nuclear protein complexes...
  47. pmc The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine
    Xiankun Zeng
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Development 140:3532-40. 2013
    ..that regulate cell lineage determination in the posterior midgut, we identified that the Osa-containing SWI/SNF (Brahma) chromatin-remodeling complex regulates Drosophila midgut homeostasis...
  48. pmc Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling
    Yunyun Jin
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    elife 2:e00999. 2013
    ..In this study, we show that Brahma (Brm) chromatin-remodeling complex is required for ISC proliferation and damage-induced midgut regeneration in a ..
  49. pmc Genetic analysis of the brahma gene of Drosophila melanogaster and polytene chromosome subdivisions 72AB
    B J Brizuela
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Genetics 137:803-13. 1994
    The brahma gene is required for activation of the homeotic genes of the Antennapedia and bithorax complexes in Drosophila. We have isolated and characterized 21 mutations in brahma...
  50. pmc Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2
    L K Elfring
    Department of Biology, University of California, Santa Cruz 95064, USA
    Genetics 148:251-65. 1998
    The Drosophila brahma (brm) gene encodes an activator of homeotic genes related to the yeast chromatin remodeling factor SWI2/SNF2. Here, we report the phenotype of null and dominant-negative brm mutations...
  51. pmc The Drosophila brahma complex is an essential coactivator for the trithorax group protein zeste
    A J Kal
    Department of Molecular and Cell Biology, MGC, Centre for Biomedical Genetics, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Genes Dev 14:1058-71. 2000
    ..Reconstituted transcription reactions established that the Brahma (BRM) chromatin-remodeling complex is essential for Zeste-directed activation on nucleosomal templates...
  52. pmc Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes
    R T Collins
    Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 14:3140-52. 2000
    ..Osa functions as a component of the Brahma chromatin-remodeling complex; other components of this complex are likewise required to repress Wingless target ..
  53. ncbi Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1
    Christian Beisel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Nature 419:857-62. 2002
    ..by Ash1 may serve as a binding surface for a chromatin remodelling complex containing the epigenetic activator Brahma (Brm), an ATPase, and inhibits the interaction of epigenetic repressors with chromatin...
  54. ncbi SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development
    Claudia B Zraly
    Department of Biology, Syracuse University, Syracuse, NY 13244 1270, USA
    Dev Biol 253:291-308. 2003
    The snr1 gene of Drosophila melanogaster encodes a conserved component of the multiprotein Brahma (Brm) complex, a counterpart to the SWI/SNF complexes that participate in ATP-dependent chromatin remodeling...
  55. ncbi Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression
    Andre Moller
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg, D 37077 Gottingen, Germany
    J Mol Biol 352:329-37. 2005
    The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans...
  56. pmc ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo
    Davide F V Corona
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
    PLoS Biol 5:e232. 2007
    ..These findings suggest that ISWI plays a global role in chromatin compaction in vivo by promoting the association of the linker histone H1 with chromatin...
  57. pmc SWI/SNF associates with nascent pre-mRNPs and regulates alternative pre-mRNA processing
    Anu Tyagi
    Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
    PLoS Genet 5:e1000470. 2009
    ..Studies in human cells suggest that Brahma (Brm), the ATPase subunit of SWI/SNF, regulates alternative pre-mRNA splicing by modulating transcription ..
  58. ncbi Genetic characterization of Drosophila Mi-2 ATPase
    Shahryar Khattak
    Department of Life Science, Kwangju Institute of Science and Technology, Kwangju, South Korea
    Gene 293:107-14. 2002
    ..The expression pattern of dMi-2 and the embryonic lethal phenotypes of mutants indicate that dMi-2 is essential for embryonic development in Drosophila melanagaster...
  59. pmc Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI
    Giosalba Burgio
    Dipartimento di Scienze Biochimiche, Universita degli Studi di Palermo, Palermo, Italy
    PLoS Genet 4:e1000089. 2008
    ..Consistent with these findings, the acetylation of histone H4 is altered when ISWI activity is perturbed in vivo. These findings suggest that ISWI associates with the Sin3A/Rpd3 complex to support its function in vivo...
  60. pmc Messenger RNA is a functional component of a chromatin insulator complex
    Leah H Matzat
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    EMBO Rep 14:916-22. 2013
    ..Together, these data suggest a novel, noncoding mechanism by which certain mRNAs contribute to chromatin insulator function. ..
  61. pmc Drosophila Brahma complex remodels nucleosome organizations in multiple aspects
    Jiejun Shi
    Department of Clinical Laboratory Medicine, Shanghai Tenth People s Hospital of Tongji University, Shanghai Key Laboratory of Signaling and Disease Research, the School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
    Nucleic Acids Res 42:9730-9. 2014
    ..In Drosophila, gene Brm encodes the core Brahma complex, the ATPase subunit of SWI/SNF class of chromatin remodelers...
  62. pmc Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathway
    Kumi Nakamura
    Department of Applied Biology and Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Nucleic Acids Res 36:3905-15. 2008
    ..in adults, which can be suppressed by half dose reduction of the osa or moira (mor) genes encoding subunits of the BRM complex. This ATP-dependent chromatin remodeling complex is known to control gene expression and the cell cycle...
  63. doi Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos
    O Lamiable
    Centre de Biophysique Moleculaire, CNRS UPR 4301, conventionnée avec l Université d Orléans, Orleans, France
    Genesis 48:244-53. 2010
    ..We show here for the first time that an RNA helicase is involved in the maintenance of homeotic genes...
  64. pmc Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD
    B Ashok Reddy
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, Netherlands
    Mol Cell Biol 30:5234-44. 2010
    ..Thus, there appears to be a hierarchical relationship in which transcription factor binding precedes remodeler recruitment...
  65. pmc Drosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators
    Sara Rodriguez-Jato
    Center for Integrative Genomics, University of Lausanne, Genopode, Lausanne, Switzerland
    PLoS ONE 6:e27479. 2011
    ..Thus, dHCF inactivation enhances the mutant phenotypes of the Pc PcG as well as brm and mor TrxG genes, suggesting that dHCF possesses Enhancer of TrxG and PcG (ETP) properties...
  66. pmc Akirin links twist-regulated transcription with the Brahma chromatin remodeling complex during embryogenesis
    Scott J Nowak
    Program in Developmental Biology, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Genet 8:e1002547. 2012
    ..To regulate transcription, Akirin colocalizes and genetically interacts with subunits of the Brahma SWI/SNF-class chromatin remodeling complex...
  67. pmc The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins
    S R Haynes
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892
    Nucleic Acids Res 20:2603. 1992
  68. ncbi Molecular mechanisms of determination in Drosophila
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Cell Biol 4:955-61. 1992
    ..Interactions between these proteins and their target selector genes are beginning to be understood, shaping our molecular view as to how stable determination of cells is achieved...
  69. pmc Regulatory regions of the homeotic gene proboscipedia are sensitive to chromosomal pairing
    A M Kapoun
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405, USA
    Genetics 140:643-58. 1995
    ..Interestingly, the intronic PS regions contain positive regulatory sequences for pb, whereas the upstream PS sites contain pb negative regulatory elements...
  70. pmc The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex
    A K Dingwall
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5427, USA
    Mol Biol Cell 6:777-91. 1995
    ..b>brahma (brm), a member of the trithorax group, encodes a protein related to the yeast SWI2/SNF2 protein, a subunit of a ..
  71. pmc Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions
    J A Eisen
    Department of Biological Sciences, Stanford University, CA 94305 5020, USA
    Nucleic Acids Res 23:2715-23. 1995
    ..g. MOT1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g...
  72. ncbi Mechanisms of heritable gene repression during development of Drosophila
    R Paro
    University of Heidelberg, Germany
    Curr Opin Cell Biol 5:999-1005. 1993
    ..Recent experiments demonstrate that, in particular, the heritable inactivation of regulatory genes relies on stable changes in the higher-order constitution of chromatin...
  73. ncbi The SNF/SWI family of global transcriptional activators
    M Carlson
    Department of Genetics and Development, Columbia University, New York, NY 10032
    Curr Opin Cell Biol 6:396-402. 1994
    ..SNF/SWI homologs have now been identified in Drosophila, mice and humans, suggesting a conserved role in transcriptional activation...
  74. ncbi The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function
    J A Kennison
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2785, USA
    Annu Rev Genet 29:289-303. 1995
    ..Among the trithorax group proteins characterized, the BRAHMA protein appears to be a subunit of a protein complex conserved from yeast to man (the SNF/SWI complex) that ..
  75. ncbi In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element
    J Mihaly
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Development 124:1809-20. 1997
    ....
  76. ncbi Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression
    V Pirrotta
    Department of Zoology, University of Geneva, Switzerland
    Trends Genet 13:314-8. 1997
    ..In vivo, complexes formed at one genomic site can interact with those at other sites, suggesting that they, like heterochromatin complexes, affect the folding of chromatin and the organization of chromosomes in the nucleus...
  77. pmc The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex
    O Rozenblatt-Rosen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 95:4152-7. 1998
    ....
  78. ncbi Transcriptional regulation: SWItching circuitry
    P A Wade
    Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, Maryland 20892 5431, USA
    Curr Biol 9:R221-4. 1999
    ..How they do so is still mysterious, but recent studies indicate that they can be targeted to the nuclear infrastructure and to particular genes, where they cooperate with other enzymes to activate or repress transcription...
  79. pmc The lawc gene is a new member of the trithorax-group that affects the function of the gypsy insulator of Drosophila
    I D Zorin
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 152:1045-55. 1999
    ..These results suggest that the lawc protein is involved in regulating the higher-order organization of chromatin...
  80. pmc Rapid purification of intact minichromosomes over a glycerol cushion
    L Di Croce
    IMT, Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Emil Mannkopff Strasse 2, D 35033 Marburg, Germany
    Nucleic Acids Res 27:e11. 1999
    ..As centrifugation through glycerol yields chromatin free of ATP and several characterized chromatin remodeling complexes, this method should be useful for structural and functional studies in vitro...
  81. ncbi ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
    R E Kingston
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, 02114 USA Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
    Genes Dev 13:2339-52. 1999
  82. ncbi Sectorial gene repression in the control of development
    E Zuckerkandl
    Institute of Molecular Medical Sciences, Stanford, CA 94309, USA
    Gene 238:263-76. 1999
    ....
  83. ncbi Are the same genes responsible for intra- and interspecific variability for sex comb tooth number in Drosophila?
    S V Nuzhdin
    Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
    Heredity (Edinb) 84:97-102. 2000
    ..One intraspecific QTL mapped to the same interval as the QTL for interspecific differences between D. simulans and D. mauritiana. Whether or not these effects result from the same genes requires further examination...
  84. ncbi Pc-G/trx-G and the SWI/SNF connection: developmental gene regulation through chromatin remodeling
    T C Gebuhr
    Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Genesis 26:189-97. 2000
    ..genesis 26:189-197, 2000...
  85. pmc Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila
    K Buchner
    Institute of Genetics, Martin Luther University of Halle, D 06108 Halle, Germany
    Genetics 155:141-57. 2000
    ....
  86. ncbi ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitro
    F J Dilworth
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP College de France 67404 Cedex CU de Strasbourg, Illkirch, France
    Mol Cell 6:1049-58. 2000
    ..Thus, both ATP-driven chromatin remodeling and HAT activities act in a temporally ordered and interdependent manner to alleviate the repressive effects of nucleosomal histones on transcription by RARalpha/RXRalpha heterodimers...
  87. pmc The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation
    N Barker
    Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    EMBO J 20:4935-43. 2001
    ..We conclude that beta-catenin recruits Brg-1 to Tcf target gene promoters, facilitating chromatin remodelling as a prerequisite for transcriptional activation...
  88. ncbi The LRR proteins capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing
    M Milan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Cell 106:785-94. 2001
    ....
  89. pmc The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus
    Stéphane Calgaro
    Centre de Biologie du Developpement, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    Genetics 160:547-60. 2002
    ..and polyhomeotic and (ii) they enhance the phenotypic effects of mutations in the trxG genes trithorax (trx), brahma (brm), and osa...
  90. ncbi Genomic imprinting in Drosophila is maintained by the products of Suppressor of variegation and trithorax group, but not Polycomb group, genes
    V Joanis
    Dept of Biology, Dalhousie University, 1355 Oxford St, Halifax, Nova Scotia B3H 1J4, Canada
    Mol Genet Genomics 268:103-12. 2002
    ..Mutant alleles of two genes in the trithorax group ( trx-G), brahma and trithorax, showed a maternal-effect enhancement of the paternal imprint...
  91. pmc Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery
    Yuri M Moshkin
    Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Genes Dev 16:2621-6. 2002
    ..Furthermore, using both genetic and biochemical methods, we demonstrate that ASF1 interacts with the Brahma (SWI/SNF) chromatin-remodelling complex...
  92. ncbi Genetic factors controlling white gene expression of the transposon A(R) 4-24 at a telomere in Drosophila melanogaster
    M L Balasov
    Institute of Cytology and Genetics, Siberian Division of Russia Academy of Sciences, Novosibirsk 630090, Russia
    Genome 45:1025-34. 2002
    ..To explain the results obtained with these modifiers, it is proposed that PEV and telomeric position effect can counteract each other at this particular cytological site...
  93. ncbi Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenance
    Lisa Maves
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403 1254, USA
    Curr Opin Genet Dev 13:472-9. 2003
    ..An important future goal is to address how signaling pathways interact with chromatin structure to regulate and maintain the proper expression of selector genes...
  94. ncbi Chromatin remodeling by ATP-dependent molecular machines
    Alexandra Lusser
    Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093 0347, USA
    Bioessays 25:1192-200. 2003
    ..In this review, we provide an overview of chromatin-remodeling enzymes and discuss two possible mechanisms by which these factors might act to reorganize nucleosome structure...
  95. pmc Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages
    Weiguo Zhang
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    Genetics 165:1341-54. 2003
    ..We propose that JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression...
  96. pmc A screen for genes regulating the wingless gradient in Drosophila embryos
    Sabrina C Desbordes
    Department of Genetics, University of Cambridge, UK
    Genetics 170:749-66. 2005
    ..screen to test for mutants and smaller deficiencies, we identified three interacting genes: dally, notum, and brahma. We confirmed that dally, as well as its homolog dally-like, and notum affect Wingless distribution in the ..
  97. ncbi Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology
    Wesley B Grueber
    Departments of Physiology and Biochemistry, University of California, San Francisco, Rock Hall, Room GD481, 1550 4th Street, San Francisco, CA 94143, USA
    Development 134:55-64. 2007
    ....
  98. pmc Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control
    Soda Balla Diop
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR6216 Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
    EMBO Rep 9:260-6. 2008
    ..We show that Rept is a component of the PRC1 PcG complex, whereas Pont purifies with the Brahma complex...
  99. doi Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity
    Svetlana Petruk
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 135:2383-90. 2008
    ..There is, however, no overall synergism or antagonism between and within the trxG and PcG proteins and, instead, only subsets of trxG proteins act synergistically...
  100. pmc The XNP remodeler targets dynamic chromatin in Drosophila
    Jonathan I Schneiderman
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:14472-7. 2009
    ..Thus, the XNP focus appears to be a functional genetic element that can contribute to gene silencing throughout the nucleus...
  101. ncbi Chromatin multiprotein complexes involved in the maintenance of transcription patterns
    V Orlando
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Germany
    Curr Opin Genet Dev 5:174-9. 1995
    ..The role of the trithorax-group factors is to counteract these repressed chromatin domains and thus to render the genes accessible to activating factors...

Research Grants4

  1. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
    ..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
  2. Fourth Symposium Biology Vertebrate Sex Determination
    Blanche Capel; Fiscal Year: 2006
    ..Understanding how critical genes in sex determining pathways evolved and how they function in lower vertebrates is expected to improve diagnosis and treatment of human disorders. [unreadable] [unreadable] [unreadable]..
  3. Organ-specific Mechanisms of Vascular Development
    Blanche Capel; Fiscal Year: 2007
    ..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. [unreadable] [unreadable]..
  4. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2010
    ....