Genomes and Genes
Gene Symbol: brm
Alias: BRD, BRM, Brahma, Brm, Brm @ Kto, CG18438, CG5942, Dmel\CG5942, E(E2F)3A, dBRM, dSMARCA4, dSNF2, l(3)72Aa, CG5942 gene product from transcript CG5942-RD, CG5942-PA, CG5942-PB, CG5942-PC, CG5942-PD, CG5942-PE, CG5942-PF, brm-PA, brm-PB, brm-PC, brm-PD, brm-PE, brm-PF, complementation group 3.5
Species: fruit fly
Publications118 found, 100 shown here
- brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2J W Tamkun
Department of Biology, University of California, Santa Cruz 95064
Cell 68:561-72. 1992The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila...
- Dosage-dependent modifiers of polycomb and antennapedia mutations in DrosophilaJ A Kennison
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892
Proc Natl Acad Sci U S A 85:8136-40. 1988..e., Sex combs reduced (Scr), Brista (Ba), trithorax (trx), Polycomb (Pc), Polycomblike (Pcl), and Sex comb on midleg (Scm)]. Mutations in several of the additional loci identified here have also been shown to have homoeotic phenotypes...
- The role of brahma and related proteins in transcription and developmentJ W Tamkun
Department of Biology, University of California, Santa Cruz 95064, USA
Curr Opin Genet Dev 5:473-7. 1995..During the past year, studies of a trithorax group member, brahma, and related yeast and human proteins have suggested that they are components of huge complexes that assist DNA-..
- Genetic interactions and dosage effects of Polycomb group genes of DrosophilaR B Campbell
Department of Zoology, University of British Columbia, Vancouver, Canada
Mol Gen Genet 246:291-300. 1995..Flies with increasing doses of esc+ exhibit anterior transformations, but these are not enhanced by mutations in trithorax group genes. The results are discussed with respect to current models of Pc group function...
- Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SWI2L K Elfring
Department of Biology, University of California, Santa Cruz 95064
Mol Cell Biol 14:2225-34. 1994The Drosophila brahma (brm) gene encodes an activator of homeotic genes that is highly related to the yeast transcriptional activator SWI2 (SNF2), a potential helicase...
- Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb regionJ A Kassis
Laboratory of Developmental Biology, Food and Drug Administration, Bethesda, Maryland 20892
Genetics 136:1025-38. 1994..I propose that engrailed PS sites normally act to promote interactions between distantly located engrailed regulatory sites and the engrailed promoter...
- ISWI, a member of the SWI2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factorT Tsukiyama
Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
Cell 83:1021-6. 1995..The convergence of biochemical and genetic studies on ISWI and SWI2/SNF2 underscores these ATPases and their close relatives as key components of independent systems for chromatin remodeling...
- The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD fingerN Tripoulas
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
Genetics 143:913-28. 1996..The chromosomal localization of ASH1 implies that it functions at the transcriptional level to maintain the expression pattern of homeotic selector genes...
- A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complexK Hagstrom
Department of Molecular Biology, Princeton University, New Jersey 08544, USA
Genetics 146:1365-80. 1997..The iab-7 PRE silencer is contained within a 0.8-kb fragment that spans a nuclease hypersensitive site, and silencing appears to depend on the chromatin remodeling protein, the GAGA factor...
- Polycomb and trithorax group proteins mediate the function of a chromatin insulatorT I Gerasimova
Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Cell 92:511-21. 1998..The results suggest a model in which PcG and TrxG proteins regulate insulator function by establishing higher order domains of chromatin organization required for the assembly of functional insulators at the nuclear matrix...
- Shaping animal body plans in development and evolution by modulation of Hox expression patternsG Gellon
Department of Biology, Yale University, New Haven, CT, USA
Bioessays 20:116-25. 1998....
- The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogasterM A Crosby
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Mol Cell Biol 19:1159-70. 1999..In vitro, MOR can bind to itself and it interacts with Brahma (BRM), an SWI2-SNF2 homolog, with which it is associated in embryonic nuclear extracts...
- The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcriptionM Vazquez
Laboratory of Molecular Genetics, National Institute of Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Development 126:733-42. 1999The trithorax group gene brahma (brm) encodes the ATPase subunit of a chromatin-remodeling complex involved in homeotic gene regulation...
- The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identityG Daubresse
Department of Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Development 126:1175-87. 1999..The Kismet proteins contain a domain conserved in the trithorax group protein Brahma and related chromatin-remodeling factors, providing further evidence that alterations in chromatin structure are ..
- Stabilization of chromatin structure by PRC1, a Polycomb complexZ Shao
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
Cell 98:37-46. 1999..Several different types of repressive complexes, including deacetylases, interact with histone tails. In contrast, PRC1 was active on nucleosomal arrays formed with tailless histones...
- Epigenetic inheritance of active chromatin after removal of the main transactivatorG Cavalli
Zentrum für Molekulare Biologie ZMBH, Universität of Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Science 286:955-8. 1999..This feature may allow epigenetic maintenance of active states of developmental genes after decay of their early embryonic regulators...
- Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genesR T Collins
Skirball Institute for Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 550 First Avenue, New York, NY 10016, USA
EMBO J 18:7029-40. 1999..We present genetic and biochemical evidence that Osa is a component of the Brahma complex, the Drosophila homolog of SWI/SNF...
- The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivoR Deuring
Department of Biology, University of California, Santa Cruz 95064, USA
Mol Cell 5:355-65. 2000..These findings reveal novel functions for the ISWI ATPase and underscore its importance in chromatin remodeling in vivo...
- The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genesM L Ruhf
UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, France
Development 128:1429-41. 2001..Altogether, the data lead us to propose that domino acts as a repressor by interfering with chromatin structure. This activity is likely to be performed as a subunit of a chromatin-remodeling complex...
- Chromatin remodeling enzymes: who's on first?C J Fry
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 301, Worcester, MA 01605, USA
Curr Biol 11:R185-97. 2001..Here we review recent developments concerning the role of chromatin remodeling enzymes in gene regulation, and propose several models to explain how different chromatin remodeling activities can be functionally coupled...
- Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteinsF Hirose
Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
Mol Cell Biol 21:7231-42. 2001..of some of the trithorax group genes involved in determining chromatin structure or chromatin remodeling (brahma, moira, and osa) significantly suppressed and that reduction of Distal-less enhanced the DREF-induced rough eye ..
- corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvaeA Lopez
Equipe Developpement et Evolution, Biologie du Développement, UMR 7622 CNRS, Universite Pierre et Marie Curie, 9, quai Saint Bernard, 75252 Paris Cedex 05, France
Mol Genet Genomics 266:572-83. 2001..Our results provide evidence that corto maintains the anterior border of Ubx expression in third-instar larvae. We suggest that this regulation is accomplished through an interaction with the products of the Pc-G and trx-G genes...
- The Drosophila BRM complex facilitates global transcription by RNA polymerase IIJennifer A Armstrong
Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
EMBO J 21:5245-54. 2002Drosophila brahma (brm) encodes the ATPase subunit of a 2 MDa complex that is related to yeast SWI/SNF and other chromatin-remodeling complexes...
- The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger proteinLuis Gutierrez
Departamento de Fisiologia Molecular y Genetica del Desarrollo, Instituto de Biotecnologia, UNAM, Cuernavaca, Morelos 62250, Mexico
Development 130:343-54. 2003The trithorax group genes are required for positive regulation of homeotic gene function. The trithorax group gene brahma encodes a SWI2/SNF2 family ATPase that is a catalytic subunit of the Brm chromatin-remodeling complex...
- The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complexDaniel R Marenda
Department of Biology, Syracuse University, New York 13244 1270, USA
Mol Cell Biol 23:289-305. 2003The Drosophila melanogaster Brahma (Brm) complex, a counterpart of the Saccharomyces cerevisiae SWI/SNF ATP-dependent chromatin remodeling complex, is important for proper development by maintaining specific gene expression patterns...
- Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by OsaPascal Heitzler
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch Cedex, Strasbourg, France
Genes Dev 17:591-6. 2003..We show here that this communication is regulated by Osa, which is recruited by Pannier and Chip. Osa belongs to Brahma chromatin remodeling complexes and we show that Osa negatively regulates ac/sc...
- Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexesLisette Mohrmann
Gene Regulation Laboratory, Centre for Biomedical Genetics, Department of Molecular and Cell Biology, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
Mol Cell Biol 24:3077-88. 2004..Therefore, it was puzzling that Drosophila appeared to contain only a single SWI/SNF-type remodeler, the Brahma (BRM) complex...
- Osa modulates the expression of Apterous target genes in the Drosophila wingMarco Milan
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Mech Dev 121:491-7. 2004..We have found Osa, a member of the Brahma chromatin-remodeling complex, as a positive modulator of Apterous activity in the Drosophila wing...
- SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complexClaudia B Zraly
Oncology Institute, Cardinal Bernardin Cancer Center, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153, USA
Genetics 168:199-214. 2004SNR1 is an essential subunit of the Drosophila Brahma (Brm) ATP-dependent chromatin remodeling complex, with counterparts in yeast (SNF5) and mammals (INI1)...
- The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase IIShrividhya Srinivasan
Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Development 132:1623-35. 2005..By contrast, the loss of KIS-L function does not affect the binding of PC to chromatin or the recruitment of Pol II to promoters. These data suggest that KIS-L facilitates an early step in transcriptional elongation by Pol II...
- Functional differentiation of SWI/SNF remodelers in transcription and cell cycle controlYuri M Moshkin
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
Mol Cell Biol 27:651-61. 2007..The two complexes share the same core subunits, including the BRM ATPase, but differ in a few signature subunits: OSA defines BAP, whereas Polybromo (PB) and BAP170 specify PBAP...
- Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in DrosophilaM Soledad Ivaldi
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
Genes Dev 21:2818-31. 2007..present evidence suggesting that JIl-1-mediated H3S10 phosphorylation is dependent on chromatin remodeling by the brahma complex and is required during early transcription elongation to release RNA polymerase II (Pol II) from promoter-..
- The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complexGillian E Chalkley
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Mol Cell Biol 28:2920-9. 2008..Both complexes share seven core subunits, including the Brahma ATPase, but differ in a few signature subunits; POLYBROMO and BAP170 specify PBAP, whereas OSA defines BAP...
- Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase IIShrividhya Srinivasan
Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA
PLoS Genet 4:e1000217. 2008..Our findings suggest that KIS-L promotes early elongation and counteracts Polycomb group repression by recruiting the ASH1 and TRX histone methyltransferases to chromatin...
- Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wingAna Terriente-Félix
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
Dev Biol 329:350-61. 2009..In Drosophila there is only one SWI/SNF protein, named Brahma, which forms the catalytic subunit of two complexes composed of different proteins...
- Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplexNadezhda E Vorobyeva
Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Vavilov Street 34 5, Moscow, 119334 Russia
Proc Natl Acad Sci U S A 106:11049-54. 2009..we have shown the existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, named BTFly (Brahma and TFIID in one assembly)...
- The novel regulator of metazoan development SAYP organizes a nuclear coactivator supercomplexNadezhda E Vorobyeva
Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
Cell Cycle 8:2152-6. 2009..SAYP function is related to the conserved domain SAY, which assembles a nuclear supercomplex BTFly consisting of Brahma and TFIID coactivators...
- Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in DrosophilaAnabel Herr
Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
Dev Biol 344:36-51. 2010..In Xenopus, Geminin acts to antagonize the Brahma (Brm) chromatin-remodeling protein, Brg1, during neural differentiation...
- 14-3-3 mediates histone cross-talk during transcription elongation in DrosophilaCaline S Karam
Department of Biology, Emory University, Atlanta, Georgia, United States of America
PLoS Genet 6:e1000975. 2010..These results suggest that 14-3-3 proteins mediate cross-talk between histone phosphorylation and acetylation at a critical step in transcription elongation...
- SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulationNadezhda E Vorobyeva
Russian Academy of Sciences, Moscow, Russia
Cell Cycle 10:1821-7. 2011..SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex...
- Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in DrosophilaDaniel Kirilly
Temasek Life Sciences Laboratory and Department of Biological Sciences, 1 Research Link, National University of Singapore, Singapore 117604
Neuron 72:86-100. 2011..Here, we analyzed 81 epigenetic factors, from which a Brahma (Brm)-containing chromatin remodeler and a histone acetyltransferase CREB-binding protein (CBP) were identified ..
- SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogasterJohan Waldholm
Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
BMC Mol Biol 12:46. 2011..SWI/SNF complexes contain one subunit with ATPase activity, which in Drosophila melanogaster is called Brahma (Brm)...
- Remodelers organize cellular chromatin by counteracting intrinsic histone-DNA sequence preferences in a class-specific mannerYuri M Moshkin
Department of Biochemistry and Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
Mol Cell Biol 32:675-88. 2012..We conclude that the cellular nucleosome landscape is the result of the balance between DNA sequence-driven nucleosome placement and active nucleosome repositioning by remodelers and the transcription machinery...
- Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27Feng Tie
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA
Mol Cell Biol 32:2323-34. 2012..on other TrxG proteins, including the histone H3K27-specific demethylase UTX and the chromatin-remodeling ATPase Brahma (BRM)...
- The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functionsTakahiro Nakayama
Department of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
Development 139:4582-90. 2012..3 replacement at chromatin boundaries. Here, we report that GAGA factor associates with the Polybromo-associated Brm (PBAP) remodeling complex, which consists of many Trithorax group proteins, and recruits this complex to chromatin ..
- Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexesHyangyee Oh
Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
Cell Rep 3:309-18. 2013..Coimmunoprecipitation and mass spectrometry identify GAGA factor (GAF), the Brahma complex, and the Mediator complex as Yorkie-associated nuclear protein complexes...
- The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestineXiankun Zeng
Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
Development 140:3532-40. 2013..that regulate cell lineage determination in the posterior midgut, we identified that the Osa-containing SWI/SNF (Brahma) chromatin-remodeling complex regulates Drosophila midgut homeostasis...
- Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signalingYunyun Jin
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
elife 2:e00999. 2013..In this study, we show that Brahma (Brm) chromatin-remodeling complex is required for ISC proliferation and damage-induced midgut regeneration in a ..
- Genetic analysis of the brahma gene of Drosophila melanogaster and polytene chromosome subdivisions 72ABB J Brizuela
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
Genetics 137:803-13. 1994The brahma gene is required for activation of the homeotic genes of the Antennapedia and bithorax complexes in Drosophila. We have isolated and characterized 21 mutations in brahma...
- Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2L K Elfring
Department of Biology, University of California, Santa Cruz 95064, USA
Genetics 148:251-65. 1998The Drosophila brahma (brm) gene encodes an activator of homeotic genes related to the yeast chromatin remodeling factor SWI2/SNF2. Here, we report the phenotype of null and dominant-negative brm mutations...
- The Drosophila brahma complex is an essential coactivator for the trithorax group protein zesteA J Kal
Department of Molecular and Cell Biology, MGC, Centre for Biomedical Genetics, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
Genes Dev 14:1058-71. 2000..Reconstituted transcription reactions established that the Brahma (BRM) chromatin-remodeling complex is essential for Zeste-directed activation on nucleosomal templates...
- Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genesR T Collins
Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Genes Dev 14:3140-52. 2000..Osa functions as a component of the Brahma chromatin-remodeling complex; other components of this complex are likewise required to repress Wingless target ..
- Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1Christian Beisel
Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Nature 419:857-62. 2002..by Ash1 may serve as a binding surface for a chromatin remodelling complex containing the epigenetic activator Brahma (Brm), an ATPase, and inhibits the interaction of epigenetic repressors with chromatin...
- SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during developmentClaudia B Zraly
Department of Biology, Syracuse University, Syracuse, NY 13244 1270, USA
Dev Biol 253:291-308. 2003The snr1 gene of Drosophila melanogaster encodes a conserved component of the multiprotein Brahma (Brm) complex, a counterpart to the SWI/SNF complexes that participate in ATP-dependent chromatin remodeling...
- Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repressionAndre Moller
Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg, D 37077 Gottingen, Germany
J Mol Biol 352:329-37. 2005The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans...
- ISWI regulates higher-order chromatin structure and histone H1 assembly in vivoDavide F V Corona
Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
PLoS Biol 5:e232. 2007..These findings suggest that ISWI plays a global role in chromatin compaction in vivo by promoting the association of the linker histone H1 with chromatin...
- SWI/SNF associates with nascent pre-mRNPs and regulates alternative pre-mRNA processingAnu Tyagi
Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
PLoS Genet 5:e1000470. 2009..Studies in human cells suggest that Brahma (Brm), the ATPase subunit of SWI/SNF, regulates alternative pre-mRNA splicing by modulating transcription ..
- Genetic characterization of Drosophila Mi-2 ATPaseShahryar Khattak
Department of Life Science, Kwangju Institute of Science and Technology, Kwangju, South Korea
Gene 293:107-14. 2002..The expression pattern of dMi-2 and the embryonic lethal phenotypes of mutants indicate that dMi-2 is essential for embryonic development in Drosophila melanagaster...
- Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWIGiosalba Burgio
Dipartimento di Scienze Biochimiche, Universita degli Studi di Palermo, Palermo, Italy
PLoS Genet 4:e1000089. 2008..Consistent with these findings, the acetylation of histone H4 is altered when ISWI activity is perturbed in vivo. These findings suggest that ISWI associates with the Sin3A/Rpd3 complex to support its function in vivo...
- Messenger RNA is a functional component of a chromatin insulator complexLeah H Matzat
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
EMBO Rep 14:916-22. 2013..Together, these data suggest a novel, noncoding mechanism by which certain mRNAs contribute to chromatin insulator function. ..
- Drosophila Brahma complex remodels nucleosome organizations in multiple aspectsJiejun Shi
Department of Clinical Laboratory Medicine, Shanghai Tenth People s Hospital of Tongji University, Shanghai Key Laboratory of Signaling and Disease Research, the School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
Nucleic Acids Res 42:9730-9. 2014..In Drosophila, gene Brm encodes the core Brahma complex, the ATPase subunit of SWI/SNF class of chromatin remodelers...
- Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathwayKumi Nakamura
Department of Applied Biology and Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
Nucleic Acids Res 36:3905-15. 2008..in adults, which can be suppressed by half dose reduction of the osa or moira (mor) genes encoding subunits of the BRM complex. This ATP-dependent chromatin remodeling complex is known to control gene expression and the cell cycle...
- Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryosO Lamiable
Centre de Biophysique Moleculaire, CNRS UPR 4301, conventionnée avec l Université d Orléans, Orleans, France
Genesis 48:244-53. 2010..We show here for the first time that an RNA helicase is involved in the maintenance of homeotic genes...
- Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRDB Ashok Reddy
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, Netherlands
Mol Cell Biol 30:5234-44. 2010..Thus, there appears to be a hierarchical relationship in which transcription factor binding precedes remodeler recruitment...
- Drosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulatorsSara Rodriguez-Jato
Center for Integrative Genomics, University of Lausanne, Genopode, Lausanne, Switzerland
PLoS ONE 6:e27479. 2011..Thus, dHCF inactivation enhances the mutant phenotypes of the Pc PcG as well as brm and mor TrxG genes, suggesting that dHCF possesses Enhancer of TrxG and PcG (ETP) properties...
- Akirin links twist-regulated transcription with the Brahma chromatin remodeling complex during embryogenesisScott J Nowak
Program in Developmental Biology, Sloan Kettering Institute, New York, New York, United States of America
PLoS Genet 8:e1002547. 2012..To regulate transcription, Akirin colocalizes and genetically interacts with subunits of the Brahma SWI/SNF-class chromatin remodeling complex...
- The bromodomain: a conserved sequence found in human, Drosophila and yeast proteinsS R Haynes
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892
Nucleic Acids Res 20:2603. 1992
- Molecular mechanisms of determination in DrosophilaM Bienz
MRC Laboratory of Molecular Biology, Cambridge, UK
Curr Opin Cell Biol 4:955-61. 1992..Interactions between these proteins and their target selector genes are beginning to be understood, shaping our molecular view as to how stable determination of cells is achieved...
- Regulatory regions of the homeotic gene proboscipedia are sensitive to chromosomal pairingA M Kapoun
Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405, USA
Genetics 140:643-58. 1995..Interestingly, the intronic PS regions contain positive regulatory sequences for pb, whereas the upstream PS sites contain pb negative regulatory elements...
- The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complexA K Dingwall
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5427, USA
Mol Biol Cell 6:777-91. 1995..b>brahma (brm), a member of the trithorax group, encodes a protein related to the yeast SWI2/SNF2 protein, a subunit of a ..
- Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functionsJ A Eisen
Department of Biological Sciences, Stanford University, CA 94305 5020, USA
Nucleic Acids Res 23:2715-23. 1995..g. MOT1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g...
- Mechanisms of heritable gene repression during development of DrosophilaR Paro
University of Heidelberg, Germany
Curr Opin Cell Biol 5:999-1005. 1993..Recent experiments demonstrate that, in particular, the heritable inactivation of regulatory genes relies on stable changes in the higher-order constitution of chromatin...
- The SNF/SWI family of global transcriptional activatorsM Carlson
Department of Genetics and Development, Columbia University, New York, NY 10032
Curr Opin Cell Biol 6:396-402. 1994..SNF/SWI homologs have now been identified in Drosophila, mice and humans, suggesting a conserved role in transcriptional activation...
- The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene functionJ A Kennison
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2785, USA
Annu Rev Genet 29:289-303. 1995..Among the trithorax group proteins characterized, the BRAHMA protein appears to be a subunit of a protein complex conserved from yeast to man (the SNF/SWI complex) that ..
- In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response elementJ Mihaly
Department of Zoology and Animal Biology, University of Geneva, Switzerland
Development 124:1809-20. 1997....
- Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expressionV Pirrotta
Department of Zoology, University of Geneva, Switzerland
Trends Genet 13:314-8. 1997..In vivo, complexes formed at one genomic site can interact with those at other sites, suggesting that they, like heterochromatin complexes, affect the folding of chromatin and the organization of chromosomes in the nucleus...
- The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complexO Rozenblatt-Rosen
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 95:4152-7. 1998....
- Transcriptional regulation: SWItching circuitryP A Wade
Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, Maryland 20892 5431, USA
Curr Biol 9:R221-4. 1999..How they do so is still mysterious, but recent studies indicate that they can be targeted to the nuclear infrastructure and to particular genes, where they cooperate with other enzymes to activate or repress transcription...
- The lawc gene is a new member of the trithorax-group that affects the function of the gypsy insulator of DrosophilaI D Zorin
Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Genetics 152:1045-55. 1999..These results suggest that the lawc protein is involved in regulating the higher-order organization of chromatin...
- Rapid purification of intact minichromosomes over a glycerol cushionL Di Croce
IMT, Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Emil Mannkopff Strasse 2, D 35033 Marburg, Germany
Nucleic Acids Res 27:e11. 1999..As centrifugation through glycerol yields chromatin free of ATP and several characterized chromatin remodeling complexes, this method should be useful for structural and functional studies in vitro...
- ATP-dependent remodeling and acetylation as regulators of chromatin fluidityR E Kingston
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, 02114 USA Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
Genes Dev 13:2339-52. 1999
- Sectorial gene repression in the control of developmentE Zuckerkandl
Institute of Molecular Medical Sciences, Stanford, CA 94309, USA
Gene 238:263-76. 1999....
- Are the same genes responsible for intra- and interspecific variability for sex comb tooth number in Drosophila?S V Nuzhdin
Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
Heredity (Edinb) 84:97-102. 2000..One intraspecific QTL mapped to the same interval as the QTL for interspecific differences between D. simulans and D. mauritiana. Whether or not these effects result from the same genes requires further examination...
- Pc-G/trx-G and the SWI/SNF connection: developmental gene regulation through chromatin remodelingT C Gebuhr
Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
Genesis 26:189-97. 2000..genesis 26:189-197, 2000...
- Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in DrosophilaK Buchner
Institute of Genetics, Martin Luther University of Halle, D 06108 Halle, Germany
Genetics 155:141-57. 2000....
- ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitroF J Dilworth
Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP College de France 67404 Cedex CU de Strasbourg, Illkirch, France
Mol Cell 6:1049-58. 2000..Thus, both ATP-driven chromatin remodeling and HAT activities act in a temporally ordered and interdependent manner to alleviate the repressive effects of nucleosomal histones on transcription by RARalpha/RXRalpha heterodimers...
- The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activationN Barker
Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
EMBO J 20:4935-43. 2001..We conclude that beta-catenin recruits Brg-1 to Tcf target gene promoters, facilitating chromatin remodelling as a prerequisite for transcriptional activation...
- The LRR proteins capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wingM Milan
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
Cell 106:785-94. 2001....
- The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatusStéphane Calgaro
Centre de Biologie du Developpement, Universite Paul Sabatier, 31062 Toulouse Cedex, France
Genetics 160:547-60. 2002..and polyhomeotic and (ii) they enhance the phenotypic effects of mutations in the trxG genes trithorax (trx), brahma (brm), and osa...
- Genomic imprinting in Drosophila is maintained by the products of Suppressor of variegation and trithorax group, but not Polycomb group, genesV Joanis
Dept of Biology, Dalhousie University, 1355 Oxford St, Halifax, Nova Scotia B3H 1J4, Canada
Mol Genet Genomics 268:103-12. 2002..Mutant alleles of two genes in the trithorax group ( trx-G), brahma and trithorax, showed a maternal-effect enhancement of the paternal imprint...
- Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machineryYuri M Moshkin
Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland
Genes Dev 16:2621-6. 2002..Furthermore, using both genetic and biochemical methods, we demonstrate that ASF1 interacts with the Brahma (SWI/SNF) chromatin-remodelling complex...
- Genetic factors controlling white gene expression of the transposon A(R) 4-24 at a telomere in Drosophila melanogasterM L Balasov
Institute of Cytology and Genetics, Siberian Division of Russia Academy of Sciences, Novosibirsk 630090, Russia
Genome 45:1025-34. 2002..To explain the results obtained with these modifiers, it is proposed that PEV and telomeric position effect can counteract each other at this particular cytological site...
- Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenanceLisa Maves
Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403 1254, USA
Curr Opin Genet Dev 13:472-9. 2003..An important future goal is to address how signaling pathways interact with chromatin structure to regulate and maintain the proper expression of selector genes...
- Chromatin remodeling by ATP-dependent molecular machinesAlexandra Lusser
Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093 0347, USA
Bioessays 25:1192-200. 2003..In this review, we provide an overview of chromatin-remodeling enzymes and discuss two possible mechanisms by which these factors might act to reorganize nucleosome structure...
- Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stagesWeiguo Zhang
Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
Genetics 165:1341-54. 2003..We propose that JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression...
- A screen for genes regulating the wingless gradient in Drosophila embryosSabrina C Desbordes
Department of Genetics, University of Cambridge, UK
Genetics 170:749-66. 2005..screen to test for mutants and smaller deficiencies, we identified three interacting genes: dally, notum, and brahma. We confirmed that dally, as well as its homolog dally-like, and notum affect Wingless distribution in the ..
- Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphologyWesley B Grueber
Departments of Physiology and Biochemistry, University of California, San Francisco, Rock Hall, Room GD481, 1550 4th Street, San Francisco, CA 94143, USA
Development 134:55-64. 2007....
- Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene controlSoda Balla Diop
Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR6216 Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
EMBO Rep 9:260-6. 2008..We show that Rept is a component of the PRC1 PcG complex, whereas Pont purifies with the Brahma complex...
- Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activitySvetlana Petruk
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Development 135:2383-90. 2008..There is, however, no overall synergism or antagonism between and within the trxG and PcG proteins and, instead, only subsets of trxG proteins act synergistically...
- The XNP remodeler targets dynamic chromatin in DrosophilaJonathan I Schneiderman
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:14472-7. 2009..Thus, the XNP focus appears to be a functional genetic element that can contribute to gene silencing throughout the nucleus...
- Chromatin multiprotein complexes involved in the maintenance of transcription patternsV Orlando
Zentrum fur Molekulare Biologie, Universitat Heidelberg, Germany
Curr Opin Genet Dev 5:174-9. 1995..The role of the trithorax-group factors is to counteract these repressed chromatin domains and thus to render the genes accessible to activating factors...
- Quantitative genomics of sexual dimorphismSergey Nuzhdin; Fiscal Year: 2005..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
- Fourth Symposium Biology Vertebrate Sex DeterminationBlanche Capel; Fiscal Year: 2006..Understanding how critical genes in sex determining pathways evolved and how they function in lower vertebrates is expected to improve diagnosis and treatment of human disorders. [unreadable] [unreadable] [unreadable]..
- Organ-specific Mechanisms of Vascular DevelopmentBlanche Capel; Fiscal Year: 2007..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. [unreadable] [unreadable]..
- OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATIONBlanche Capel; Fiscal Year: 2010....