Genomes and Genes
Gene Symbol: brat
Description: brain tumor
Alias: BRAT, Brat, CG10719, Dmel\CG10719, E60, anon-37CDa, fs(2)ltoPM43, l(2)37Cf, l(2)E60, l(2)brat, lincRNA.S1565, CG10719 gene product from transcript CG10719-RE, CG10719-PA, CG10719-PB, CG10719-PC, CG10719-PE, CG10719-PF, brain tumour, brat-PA, brat-PB, brat-PC, brat-PE, brat-PF
Species: fruit fly
- Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryosPark F Cho
Department of Biochemistry and McGill Cancer Center, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
Curr Biol 16:2035-41. 2006..requires an mRNP complex (the NRE complex), which consists of Nanos (Nos), Pumilio (Pum), and Brain tumor (Brat) proteins, and the Nos responsive element (NRE) present in the 3' UTR of hb mRNA ...
- The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesisDeborah J Frank
Division of Basic Sciences and Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Development 129:399-407. 2002..We now indicate that the Drosophila melanogaster tumor suppressor brain tumor (brat) is an inhibitor of cell growth and is a functional homolog of the C. elegans gene ncl-1...
- Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewalCheng Yu Lee
Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
Dev Cell 10:441-9. 2006..Here, we report that the Brain tumor (Brat) translation repressor is partitioned into GMCs via direct interaction with the Miranda scaffolding protein...
- Connecting cancer to the asymmetric division of stem cellsAndreas Wodarz
Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain CMPB, University of Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
Cell 124:1121-3. 2006..one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell...
- Drosophila Brain Tumor is a translational repressorJ Sonoda
Howard Hughes Medical Institute, Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
Genes Dev 15:762-73. 2001The Drosophila brain tumor (brat) gene encodes a member of the conserved NHL family of proteins, which appear to regulate differentiation and growth in a variety of organisms...
- Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cellsJoerg Betschinger
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
Cell 124:1241-53. 2006..neuroblasts-stem cell-like precursors of the adult brain-regulate proliferation by segregating the growth inhibitor Brat and the transcription factor Prospero into only one daughter cell...
- The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell divisionSarah K Bowman
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
Dev Cell 10:731-42. 2006..This can lead to symmetric segregation of the cell fate determinants Brat and Prospero, resulting in the mis-specification of daughter cell fates and tumor-like over proliferation in the ..
- Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brainE Arama
Department of Biology, Technion Israel Institute of Technology, Haifa
Oncogene 19:3706-16. 2000Inactivation of both alleles of the fruit fly D. melanogaster brain tumor (brat) gene results in the production of a tumor-like neoplasm in the larval brain, and lethality in the larval third instar and pupal stages...
- The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of DrosophilaBruno Bello
Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
Development 133:2639-48. 2006..in brat mutant clones promotes cell cycle exit and differentiation of brat mutant cells, thereby abrogating brain tumour formation...
- Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signalingRobin E Harris
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Dev Cell 20:72-83. 2011..Here, we identify Brain Tumor (Brat) as a potent differentiation factor and target of Pum-Nos regulation...
- Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblastsHongyan Wang
Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
Genes Dev 20:3453-63. 2006..We have identified a novel mechanism for controlling the balance between self-renewal and neuronal differentiation during the asymmetric division of Drosophila larval NBs...
- Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientationCheng Yu Lee
Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
Genes Dev 20:3464-74. 2006..We conclude that Aurora-A and Numb are novel inhibitors of neuroblast self-renewal and that spindle orientation regulates neuroblast self-renewal...
- Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisionsRita Sousa-Nunes
Department of Biological Sciences, Temasek Life Sciences Laboratory, National University of Singapore, Singapore
Genes Dev 23:359-72. 2009..Our findings suggest that Flfl may target PP4 to the MIra protein complex to facilitate dephosphorylation step(s) crucial for its cortical association/asymmetric localization...
- Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary propertiesMarco Sardiello
Telethon Institute of Genetics and Medicine, Via P, Castellino 111, 80131 Naples, Italy
BMC Evol Biol 8:225. 2008..TRIM genes are involved in ubiquitylation and are implicated in a variety of human pathologies, from Mendelian inherited disorders to cancer, and are also involved in cellular response to viral infection...
- Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineageRalph A Neumüller
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
Nature 454:241-5. 2008..neuroblasts segregate the Trim-NHL (tripartite motif and Ncl-1, HT2A and Lin-41 domain)-containing protein Brain tumour (Brat) into one of the two daughter cells, ovarian stem cells are regulated by an extracellular signal from the ..
- The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitorsStephan Speicher
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas University Miguel Hernandez, Sant Joan d Alacant, 03550 Alicante, Spain
Curr Biol 18:831-7. 2008....
- The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in DrosophilaSarah K Bowman
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
Dev Cell 14:535-46. 2008..PAN neuroblasts rely on the segregating determinants Numb and Brat to generate smaller, secondary neuroblasts that in turn give rise to ganglion mother cells (GMCs) and neurons ..
- Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogasterEmmanuel Caussinus
Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nat Genet 37:1125-9. 2005....
- Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneuronsNara I Muraro
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
J Neurosci 28:2099-109. 2008..the cofactor Nanos is essential for Pum-dependent para repression, whereas the requirement for Brain Tumor (Brat) is cell type specific...
- The mei-P26 gene encodes a RING finger B-box coiled-coil-NHL protein that regulates seizure susceptibility in DrosophiliaEdward Glasscock
Department of Molecular and Cell Biology, Division of Neurobiology, University of California, Berkeley, CA 94720, USA
Genetics 170:1677-89. 2005..These results reveal a surprising role for mei-P26 outside of the germline as a regulator of seizure susceptibility, possibly by affecting synaptic development as a ubiquitin ligase...
- Combinatorial use of translational co-factors for cell type-specific regulation during neuronal morphogenesis in DrosophilaEugenia C Olesnicky
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
Dev Biol 365:208-18. 2012..Through an RNA interference screen we uncover a role for the translational co-factor Brain Tumor (Brat) in dendrite morphogenesis of da neurons and demonstrate that Nos, Pum, and Brat interact genetically to regulate ..
- Origin and diversification of TRIM ubiquitin ligasesIgnacio Marín
Instituto de Biomedicina de Valencia IBV CSIC, Consejo Superior de Investigaciones Cientificas, Valencia, Spain
PLoS ONE 7:e50030. 2012..The structural and evolutionary links with the TRAF family of ubiquitin ligases can be experimentally explored to determine whether functional connections also exist...
- Neural stem cells in Drosophila: molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formationNidhi Saini
Biozentrum, University of Basel, 4056 Basel, Switzerland
Stem Cells Int 2012:486169. 2012..These cellular and molecular findings in Drosophila are likely to provide valuable genetic links for analyzing mammalian neural stem cells and tumor biology...
- Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cellsCatarina C F Homem
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, 1030 Vienna, Austria
Cell 158:874-88. 2014..Our findings show that cell size control can be modified by systemic hormonal signaling and reveal a unique connection between metabolism and proliferation in stem cells. ..
- Phosphotyrosyl phosphatase activator facilitates localization of Miranda through dephosphorylation in dividing neuroblastsFan Zhang
College of Life Sciences, Zhejiang University, Hangzhou 310058, China
Development 143:35-44. 2016..On the basis of these results, a two-step process for the basal localization of Mira during NB division is revealed: cortical association of Mira mediated by the PTPA-PP4 complex is followed by apical aPKC-mediated basal restriction. ..
- Aneuploidy causes premature differentiation of neural and intestinal stem cellsDelphine Gogendeau
Institut Curie, PSL Research University, CNRS UMR144, 12 rue Lhomond, Paris 75005, France
Nat Commun 6:8894. 2015..Our work highlights a neural and intestine stem cell-specific response to aneuploidy, which prevents their proliferation and expansion. ..
- Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during developmentFay G Newton
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Development 142:3362-73. 2015..of BMP signalling, one GSC daughter differentiates into a cystoblast (CB) and this fate is stabilised by Brain tumour (Brat) and Pumilio (Pum)-mediated post-transcriptional repression of mRNAs, including that encoding the Dpp ..
- EAG2 potassium channel with evolutionarily conserved function as a brain tumor targetXi Huang
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California, USA
Nat Neurosci 18:1236-46. 2015..Our findings illustrate the potential of targeting ion channels in cancer treatment. ..
- Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transitionJohn D Laver
Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
Genome Biol 16:94. 2015Brain tumor (BRAT) is a Drosophila member of the TRIM-NHL protein family. This family is conserved among metazoans and its members function as post-transcriptional regulators...
- A role for the serine/arginine-rich (SR) protein B52/SRSF6 in cell growth and myc expression in DrosophilaCéline Fernando
Institut de Genetique Moleculaire de Montpellier, Unite Mixte de Recherche 5535, Centre National de la Recherche Scientifique, 1919 Route de Mende, 34293 Montpellier Cedex 5, France Université de Montpellier, 163 rue Auguste Broussonnet, 34090 Montpellier, France
Genetics 199:1201-11. 2015..We show that upregulation of brain tumor (brat), a tumor suppressor and post-transcriptional repressor of myc, and downregulation of lilliputian (lilli), a ..
- ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous systemKatarzyna Oktaba
Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California, Berkeley, Berkeley, CA 94720 3200, USA
Mol Cell 57:341-8. 2015..ChIP-seq assays identify ELAV in the promoter regions of extended genes. Our study provides evidence for a regulatory link between promoter-proximal pausing and APA. ..
- Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor buttonheadHideyuki Komori
Center for Stem Cell Biology, Life Sciences Institute, University of Michigan Medical School, Ann Arbor, United States
elife 3:. 2014..Thus, Trx instructs a type II neuroblast functional identity by epigenetically promoting Btd expression, thereby maintaining neuroblast functional heterogeneity. ..
- How to be at the right place at the right time: the importance of spindle positioning in embryosKathleen S Moorhouse
Department of Biology, Boston College, Chestnut Hill, Massachusetts
Mol Reprod Dev 81:884-95. 2014..The data generated from these model organisms have made unique contributions to our knowledge of spindle positioning. Future work will address how all of these different factors work together to regulate the position of the spindle...
- ELAV mediates 3' UTR extension in the Drosophila nervous systemValérie Hilgers
Division of Genetics, Genomics, and Development, Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California at Berkeley, Berkeley, California 94720, USA
Genes Dev 26:2259-64. 2012..We propose that this mechanism for coordinating 3' UTR extension may be generally used in a variety of cellular processes...
- Basolateral junction proteins regulate competition for the follicle stem cell niche in the Drosophila ovaryMaria R Kronen
University of California, San Francisco, Center for Reproductive Sciences, Departments of Anatomy and OB GYN RS, San Francisco, California, United States of America
PLoS ONE 9:e101085. 2014..In addition, we demonstrate that the neutral drift model can be adapted to quantify non-neutral behavior of mutant clones. ..
- Dedifferentiation of neurons precedes tumor formation in Lola mutantsTony D Southall
The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Dev Cell 28:685-96. 2014..In lola mutants, neurons dedifferentiate, turn on neural stem cell genes, and begin to divide, forming tumors. Thus, neurons rather than stem cells or intermediate progenitors are the tumor-initiating cells in lola mutants...
- It takes two to tango, a dance between the cells of origin and cancer stem cells in the Drosophila larval brainDerek H Janssens
Program in Cellular and Molecular Biology, USA
Semin Cell Dev Biol 28:63-9. 2014..Brain tumor (Brat) and Numb initiate this cascade by asymmetrically extinguishing the activity of the self-renewal factors...
- Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factorsDerek H Janssens
Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Development 141:1036-46. 2014..Here, we report that the transcriptional repressor protein Earmuff (Erm) functions temporally after Brain tumor (Brat) and Numb to restrict the developmental potential of uncommitted (immature) INPs...
- Epithelial polarity and spindle orientation: intersecting pathwaysDan T Bergstralh
The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Philos Trans R Soc Lond B Biol Sci 368:20130291. 2013..In this review, we examine several factors implicated in both processes, namely Canoe, Bazooka, aPKC and Discs large, and consider the implications of this work on how the spindle is oriented during epithelial cell divisions. ..
- Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing mad expressionWenwen Shi
Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
J Neurosci 33:12352-63. 2013..Here we report that brain tumor (brat), which was identified as a translational repressor in multiple biological processes, plays a crucial role at ..
- Hedgehog signaling acts with the temporal cascade to promote neuroblast cell cycle exitPhing Chian Chai
Temasek Life Sciences Laboratory, National University of Singapore, Singapore
PLoS Biol 11:e1001494. 2013..Interestingly, hh is likely a target of Castor. Hence, Hh signaling provides a link between the temporal series and the asymmetric division machinery in scheduling the end of neurogenesis...
- Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear TransportSubhas Mukherjee
Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia
Cancer Res 76:2443-52. 2016..Mutation of a single gene in Drosophila, Brain Tumor (Brat), leads to disrupted asymmetric cell division resulting in dramatic neoplastic proliferation of neuroblasts and ..
- Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylationClaudia Temme
Institute of Biochemistry and Biotechnology, Martin Luther University Halle Wittenberg, 06099 Halle, Germany
RNA 16:1356-70. 2010..Nocturnin may also be involved in mRNA deadenylation, whereas there is no evidence for a similar role of Angel and 3635...
- Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell linesSteven E Justiniano
Department of Molecular Genetics, Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 7:e31417. 2012..We conclude that the use of Pten mutants is a powerful means to derive new Drosophila cell lines...
- Pumilio facilitates miRNA regulation of the E2F3 oncogeneWayne O Miles
Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Harvard Medical School, Charlestown, 02129, USA
Genes Dev 26:356-68. 2012..These studies suggest that Pumilio-miRNA repression of E2F3 translation provides an important level of E2F regulation that is frequently abrogated in cancer cells...
- Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brainsSijun Zhu
Department of Physiology, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:20615-20. 2011..Our findings suggest that PntP1 is both necessary and sufficient for the suppression of Ase in type II NBs and the generation of INPs in Drosophila larval brains...
- Widespread generation of alternative UTRs contributes to sex-specific RNA binding by UNRMarija Mihailovic
Gene Regulation Programme, Centre for Genomic Regulation CRG and UPF, 08003 Barcelona, Spain
RNA 18:53-64. 2012..These results suggest that UNR exploits the transcript diversity generated by alternative processing and alternative promoter usage to bind and regulate target genes in a sex-specific manner...
- Drosophila Pumilio protein contains multiple autonomous repression domains that regulate mRNAs independently of Nanos and brain tumorChase A Weidmann
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA
Mol Cell Biol 32:527-40. 2012..Other PUF proteins lack these repression domains. Our findings suggest that PUF proteins have evolved new regulatory functions through protein sequences appended to their conserved PUF repeat RNA-binding domains...
- Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signalingYun Li
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9148, USA
Development 139:1547-56. 2012..Loss of mei-P26 results in premature translation of the BMP antagonist Brat in germline stem cells...
- Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewalKai Chen Chang
Temasek Life Sciences Laboratory, 1 Research Link, Singapore 117604
Dev Cell 19:778-85. 2010..Thus, reciprocal repression between Zif and aPKC act as a critical regulatory mechanism for establishing cell polarity and controlling neuroblast self-renewal...
- Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnoverTomoko Mastushita-Sakai
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
Proc Natl Acad Sci U S A 107:11987-92. 2010..These targets suggest that the persistent form of the memory trace might be comprised of molecules that maintain a sustained, permissive environment for synaptic growth in an activated synapse...
- klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast divisionQi Xiao
Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Development 139:2670-80. 2012..These results led us to propose that multiple mechanisms converge to exert precise control of klu and distinguish a progenitor cell from its sibling stem cell during asymmetric neuroblast division...
- Structure of Pumilio reveals similarity between RNA and peptide binding motifsT A Edwards
Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA
Cell 105:281-9. 2001..This analysis suggests that similar features in helical repeat proteins are used to bind extended peptides and RNA...
- The Wilhelmine E. Key 1992 Invitational lecture. Phenotypic analysis of the Dopa decarboxylase gene cluster mutants in Drosophila melanogasterT R Wright
University of Virginia, Department of Biology, Charlottesville 22903 2477, USA
J Hered 87:175-90. 1996..Thus, the Ddc gene cluster represents in higher eukaryotes an unusual example of a large cluster of functionally related genes involved in a common physiological process...
- derailed is required for muscle attachment site selection in DrosophilaC A Callahan
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, San Diego, CA 92186, USA
Development 122:2761-7. 1996..The data suggest that both neurons and muscles use common mechanisms to recognize their paths or targets, and that Drl plays an analogous role in both developing systems...
- Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genesE Woodhouse
Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Dev Genes Evol 207:542-50. 1998....
- Dual-tagging gene trap of novel genes in Drosophila melanogasterT Lukacsovich
School of Human Sciences and Advanced Research Institute for Science and Engineering, Waseda University, Saitama 359 1192, Japan
Genetics 157:727-42. 2001....
- Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskinJ A Lorenzen
Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Development 128:1403-14. 2001..Mutations in the Drosophila Importin beta homolog Ketel, also reduce the nuclear localization of activated D-ERK. Together, these data indicate that DIM-7 and Ketel are components of the nuclear import machinery for activated D-ERK...
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Genetics 84:287-310. 1976..Although no biochemical phene has yet been established for the alphaMD hypersensitive amd alleles, it seems likely that the two groups of mutants are functionally related...
- The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogasterD G Stathakis
Department of Biology, University of Virginia, Charlottesville 22903 2477, USA
Genetics 141:629-55. 1995....
- Effects of Ddc cluster lethal alleles on ovary growth, attachment, and egg production in DrosophilaE McCrady
Department of Biology, University of North Carolina at Greensboro 27412
J Exp Zool 268:469-76. 1994..Heteroallelic heterozygotes of Bd7 x Bd4 also produced fully fertile ovaries, but no other heteroallelic combinations did so.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family memberC A Callahan
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, California 92186, USA
Nature 376:171-4. 1995..In drl mutant embryos these neurons fail to make the correct pathway choices. Our results provide evidence for receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition...
- The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 regionT R Wright
Chromosoma 83:45-58. 1981..It eliminates Ddc+ and 1(2)37Ca+ function and at 30 degrees C reduces 1(2)37Ce+ function. It is not a deficiency but could be a polar mutant...
- Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase geneD Gilbert
Genetics 106:679-94. 1984..Six of these complementation groups are within 23 kb of DNA, and all ten complementation groups, including Ddc, lie within 78-82 kb of DNA. The potential significance of this unusually high gene density is discussed...
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Genetics 112:843-59. 1986..The Dox-A2 locus is within 3.4 to 4.4 kb of the Df(2L)OD15 breakpoint, placing four of the vital loci within a maximum of 15.5 kb. The location of Dox-A2 in a cluster of genes affecting cuticle formation is discussed...
- Tumor-suppressor genes of Drosophila melanogasterE Gateff
Institute of Genetics, Johannes Gutenberg University, Mainz, West Germany
Crit Rev Oncog 1:221-45. 1989
- The fruit fly Drosophila and the fish Xiphophorus as model systems for cancer studiesB Mechler
Department of Development Genetics, Deutsches Krebsforschungszentrum, German Cancer Research Center, Heidelberg
Cancer Surv 9:505-27. 1990..This gene encodes a receptor tyrosine kinase related to the EGF-receptor, and its activation and overexpression are thought to play a critical part in melanoma formation...
- Regulation of the Drosophila lin-41 homologue dappled by let-7 reveals conservation of a regulatory mechanism within the LIN-41 subcladeFergal O'Farrell
Department of Natural Sciences, Södertörns högskola, Huddinge, Sweden
Dev Dyn 237:196-208. 2008..A cell-based assay verified let-7 miRNA down-regulation of dpld expression by means of its 3'-untranslated region. Thus, dpld seems also to be miRNA regulated, suggesting that miRNAs represent an ancient mechanism of LIN-41 regulation...
- Development. The message is in the translationJ D Richter
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 293:60-2. 2001
- A PUF family portrait: 3'UTR regulation as a way of lifeMarvin Wickens
Dept of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
Trends Genet 18:150-7. 2002..Here, we discuss the evolution, biological function and mechanisms of action of the PUF protein family, and suggest that a primordial function of PUF proteins is to sustain mitotic proliferation of stem cells...
- Control of developmental timing by micrornas and their targetsAmy E Pasquinelli
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
Annu Rev Cell Dev Biol 18:495-513. 2002..Instead of inventing new gene functions, even subtle changes in temporal expression of pre-existing control genes can result in speciation by altering the time at which they function...
- Translational repressors in DrosophilaKellie A Dean
Howard Hughes Medical Institute, Dept of Molecular Genetics and Microbiology, Box 3657, Duke University Medical Center, Durham, NC 27710, USA
Trends Genet 18:572-7. 2002..These repressors do not work in isolation - each binds multiple sites in the appropriate mRNA, and the resulting RNA-protein complexes appear to recruit co-repressors by a variety of mechanisms...
- Model of the brain tumor-Pumilio translation repressor complexThomas A Edwards
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
Genes Dev 17:2508-13. 2003The Brain Tumor (Brat) protein is recruited to the 3' untranslated region (UTR) of hunchback mRNA to regulate its translation...
- How cells coordinate growth and divisionPaul Jorgensen
Department of Medical Genetics and Microbiology, University of Toronto, Toronto ON, Canada M5S 1A8
Curr Biol 14:R1014-27. 2004..Recently, genetic screens in Drosophila and functional genomics approaches in yeast have macheted into the thicket of cell size control...
- The myb-related gene stonewall induces both hyperplasia and cell death in Drosophila: rescue of fly lethality by coexpression of apoptosis inducersS Brun
Laboratoire de Genetique et Biologie Cellulaire, CNRS MR 8159, Universite de Versailles St Quentin en Yvelines, 45 Avenue des Etats Unis, F 78035 Versailles cedex, France
Cell Death Differ 13:1752-62. 2006..Our results suggest that stwl(UY823) kills flies by causing inappropriate cell cycle entry, and that triggering the death of these overproliferating cells or slowing their proliferation restores viability...
- Drosophila brain tumor metastases express both neuronal and glial cell type markersMichelle Beaucher
Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA
Dev Biol 301:287-97. 2007Loss of either lgl or brat gene activity in Drosophila larvae causes neoplastic brain tumors. Fragments of tumorous brains from either mutant transplanted into adult hosts over-proliferate, and kill their hosts within 2 weeks...
- A broadly conserved pathway generates 3'UTR-directed primary piRNAsNicolas Robine
Department of Developmental Biology, Sloan Kettering Institute, New York, NY 10065, USA
Curr Biol 19:2066-76. 2009..Certain stages of mammalian testis also accumulate abundant piRNAs of unknown function, which derive from noncoding RNAs that are depleted in transposable element content and do not engage in ping-pong...
- The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteinsViktoria Hessle
Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
Mol Biol Cell 20:3459-70. 2009..Our results lead to a revised mechanistic model for cotranscriptional quality control in which the exosome is constantly recruited to newly synthesized RNAs through direct interactions with specific hnRNP proteins...
- Modulated modularity clustering as an exploratory tool for functional genomic inferenceEric A Stone
Department of Statistics, North Carolina State University, Raleigh, NC, USA
PLoS Genet 5:e1000479. 2009..We show MMC to be effective and suitable to applications of large scale. In light of these features, we advocate MMC as a standard tool for exploration and hypothesis generation...
- Metastatic ability of Drosophila tumors depends on MMP activityMichelle Beaucher
Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA
Dev Biol 303:625-34. 2007We analyzed how cells from tumors caused by mutations in either lgl or brat use matrix metalloproteinases (MMPs) to facilitate metastasis in Drosophila...
- A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brainMitsuhiko Kurusu
Structural Biology Center, National Institute of Genetics, and Department of Genetics, The Graduate University for Advanced Studies, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
Dev Biol 326:224-36. 2009..These results as a whole uncover a distinct regulatory mechanism of self-renewal and differentiation of the MB progenitors that is different from the mechanisms found in other progenitors...
- Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating PonHongyan Wang
Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
Nature 449:96-100. 2007..Our results reveal a biochemical link between the cell cycle and the asymmetric protein localization machinery, and indicate that Polo can inhibit progenitor self-renewal by regulating the localization and function of Numb...
- Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase-promoting complex/cyclosomeCathy Slack
MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
Development 134:3781-7. 2007..the asymmetric localisation of the adapter protein Miranda and its associated cargo proteins Staufen, Prospero and Brat, but not other components of the asymmetric division machinery...
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