bnl

Summary

Gene Symbol: bnl
Description: branchless
Alias: BNL, Bnl, CG4608, DFGF, DmBnl, Dmel\CG4608, FGF, dFGF, l(3)06916, l(3)neo52, CG4608 gene product from transcript CG4608-RA, CG4608-PA, CG4608-PC, CG4608-PD, bnl-PA, bnl-PC, bnl-PD, fibroblast growth factor, fibroblast growth factor protein, fibroblast growth factor)
Species: fruit fly

Top Publications

  1. ncbi Hedgehog signaling patterns the tracheal branches
    L Glazer
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 128:1599-606. 2001
  2. pmc Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia
    Nathan T Mortimer
    Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Dev Biol 329:294-305. 2009
  3. ncbi Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF
    J Jarecki
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 99:211-20. 1999
  4. doi Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting
    Lazaro Centanin
    Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Dev Cell 14:547-58. 2008
  5. pmc Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brain
    A L Barrett
    Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, TX 77843 2128, USA
    Dev Biol 317:234-45. 2008
  6. pmc Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis
    Dong Yan
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 312:203-16. 2007
  7. ncbi Tramtrack regulates different morphogenetic events during Drosophila tracheal development
    Sofia J Araújo
    Institut de Biologia Molecular de Barcelona IBMB CSIC, Parc Cientific de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Development 134:3665-76. 2007
  8. ncbi Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development
    U Nussbaumer
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Mech Dev 96:27-36. 2000
  9. pmc The Drosophila Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells
    Samir Merabet
    Biozentrum der Universitat Basel, Switzerland
    EMBO Rep 6:762-8. 2005
  10. ncbi Control of tracheal tubulogenesis by Wingless signaling
    T Chihara
    Genetic Strain Research Center and The Graduate University for Advanced Studies, National Institute of Genetics, Mishima 411 8540, Japan
    Development 127:4433-42. 2000

Scientific Experts

Detail Information

Publications95

  1. ncbi Hedgehog signaling patterns the tracheal branches
    L Glazer
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Development 128:1599-606. 2001
    ..Signaling by several pathways, including the Hh pathway, thus serves to subdivide the uniform population of tracheal cells into distinct cell types that will subsequently be recruited into the different branches...
  2. pmc Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia
    Nathan T Mortimer
    Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Dev Biol 329:294-305. 2009
    ..activating a program of branching and growth driven by HIF-1alpha/sima-dependent expression of the breathless (btl) FGF receptor...
  3. ncbi Oxygen regulation of airway branching in Drosophila is mediated by branchless FGF
    J Jarecki
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 99:211-20. 1999
    ..We provide evidence that the critical signal is Branchless (Bnl) FGF, the same growth factor that patterns the major branches during embryogenesis...
  4. doi Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting
    Lazaro Centanin
    Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Dev Cell 14:547-58. 2008
    ..This response involves the upregulation of FGF/Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells...
  5. pmc Branchless and Hedgehog operate in a positive feedback loop to regulate the initiation of neuroblast division in the Drosophila larval brain
    A L Barrett
    Department of Biochemistry and Biophysics, MS 2128, Texas A and M University, College Station, TX 77843 2128, USA
    Dev Biol 317:234-45. 2008
    ..Initiation of neuroblast proliferation requires signaling by the Fibroblast Growth Factor homolog Branchless and by the Hedgehog growth factor...
  6. pmc Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis
    Dong Yan
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Dev Biol 312:203-16. 2007
    ..Rescue experiments in dlp embryos demonstrate that Dlp functions only in Bnl/FGF receiving cells in a cell-autonomous manner, but is not essential for Bnl/FGF expression cells...
  7. ncbi Tramtrack regulates different morphogenetic events during Drosophila tracheal development
    Sofia J Araújo
    Institut de Biologia Molecular de Barcelona IBMB CSIC, Parc Cientific de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Development 134:3665-76. 2007
    ..In summary, the involvement of Ttk in different steps of tube morphogenesis identifies it as a key player in tracheal development...
  8. ncbi Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development
    U Nussbaumer
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Mech Dev 96:27-36. 2000
    ..of the DSRF regulatory region reveals that a single enhancer element, which is under the control of the fibroblast growth factor (FGF)-receptor signalling pathway, is sufficient to induce DSRF expression in the terminal tracheal cells...
  9. pmc The Drosophila Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells
    Samir Merabet
    Biozentrum der Universitat Basel, Switzerland
    EMBO Rep 6:762-8. 2005
    ..by the local and highly dynamic expression profile of branchless (bnl), which encodes a secreted fibroblast growth factor (FGF)-like molecule...
  10. ncbi Control of tracheal tubulogenesis by Wingless signaling
    T Chihara
    Genetic Strain Research Center and The Graduate University for Advanced Studies, National Institute of Genetics, Mishima 411 8540, Japan
    Development 127:4433-42. 2000
    ..The tracheal primordium undergoes primary branching induced by the FGF homolog Branchless, differentiates cells with specialized functions such as fusion cells, which perform target ..
  11. ncbi Hedgehog and Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea
    Kagayaki Kato
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo ku Kobe 650 0047, Japan
    Development 131:5253-61. 2004
    ..Orthogonal expression of Hedgehog and Decapentaplegic in the epidermis instructs monopolar extension of the terminal branch along the posterior compartment, thereby matching the pattern of airway growth with that of the epidermis...
  12. pmc Regulation of Drosophila matrix metalloprotease Mmp2 is essential for wing imaginal disc:trachea association and air sac tubulogenesis
    Arjun Guha
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Dev Biol 335:317-26. 2009
    The Drosophila Dorsal Air Sac Primordium (ASP) is a tracheal tube that grows toward Branchless FGF-expressing cells in the wing imaginal disc...
  13. ncbi Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division
    Youngji Park
    Department of Biochemistry and Biophysics, Texas A and M University, TAMU 2128, College Station, TX 77843 2128, USA
    Dev Biol 253:247-57. 2003
    ..we show that trol encodes the Drosophila homolog of Perlecan and regulates neuroblast division by modulating both FGF and Hh signaling...
  14. ncbi Tube or not tube: remodeling epithelial tissues by branching morphogenesis
    Markus Affolter
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, CH 4056, Basel, Switzerland
    Dev Cell 4:11-8. 2003
    ....
  15. ncbi ribbon encodes a novel BTB/POZ protein required for directed cell migration in Drosophila melanogaster
    P L Bradley
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, Maryland 21205 2196, USA
    Development 128:3001-15. 2001
    ..b>FGF signaling is required for guided migration of all tracheal branches, whereas the DPP, EGF receptor, and Wingless/..
  16. ncbi Functional subdivision of trunk visceral mesoderm parasegments in Drosophila is required for gut and trachea development
    Chie Hosono
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 130:439-49. 2003
    ....
  17. ncbi Branch-specific migration cues in the Drosophila tracheal system
    Dalia Rosin
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Bioessays 24:110-3. 2002
    ..guiding system in the migration process of all branches is the dynamic and localized expression of Branchless (Bnl), an FGF-like molecule...
  18. ncbi In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis
    Carlos Ribeiro
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 2:677-83. 2002
    ..The chemoattractant Branchless/FGF (Bnl) appears to guide cell migration and is essential for the formation of all tracheal branches, while Decapentaplegic ..
  19. ncbi Stripe provides cues synergizing with branchless to direct tracheal cell migration
    Ruslan Dorfman
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Biol 252:119-26. 2002
    ..sr-mutant embryos exhibit defects in migration of all tracheal branches. Although the FGF ligand Branchless (Bnl) is expressed in a subset of tendon-precursor cells independently of Sr, Bnl functions ..
  20. pmc Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar
    Sofía Lavista-Llanos
    Instituto de Investigaciones Bioquimicas Fundacion Campomar, Buenos Aires 1405, Argentina
    Mol Cell Biol 22:6842-53. 2002
    ..Tight conservation of the HIF/prolyl hydroxylase system in Drosophila provides a new focus for understanding oxygen homeostasis in intact multicellular organisms...
  21. ncbi Ligand-dependent activation of breathless FGF receptor gene in Drosophila developing trachea
    Tomokazu Ohshiro
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyou ku, Tokyo 113 0033, Japan
    Mech Dev 114:3-11. 2002
    ..Biochemical and genetic analysis indicated that the minimum btl enhancer includes binding sites of Anterior-open...
  22. ncbi FGF is an essential mitogen and chemoattractant for the air sacs of the drosophila tracheal system
    Makoto Sato
    Department of Biochemistry and Biophysics, University of California, San Francisco, 94143, USA
    Dev Cell 3:195-207. 2002
    ..During the third larval instar, air sac precursor cells bud from a tracheal branch in response to FGF, and then they proliferate and migrate to the adepithelial layer of the wing imaginal disc...
  23. ncbi branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching
    D Sutherland
    Department of Biochemistry, Beckman Center, Stanford University School of Medicine, California 94305 5307, USA
    Cell 87:1091-101. 1996
    ..growth factors (FGFs) and appears to function as a ligand for the breathless receptor tyrosine kinase, an FGF receptor homolog expressed on developing tracheal cells...
  24. pmc Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration
    Elisenda Buti
    Developmental Biology Department, Institute of Molecular Biology of Barcelona IBMB CSIC, Barcelona, Spain Cell and Developmental Biology Programme, Institute for Research in Biomedicine IRB Barcelona, Barcelona, Spain
    PLoS ONE 9:e92682. 2014
    ..the cellular consequences of overactivated Hh signalling, using ptc mutants, we found that Hh positively regulates Bnl/FGF levels during embryonic stages...
  25. ncbi Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes
    P Wappner
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Development 124:4707-16. 1997
    ..Antagonistic interactions between the two pathways are demonstrated. The opposing activities of two pathways may refine the final determination of tracheal branch fates...
  26. ncbi sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
    N Hacohen
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 92:253-63. 1998
    ..Here, we describe an antagonist of FGF signaling that patterns apical branching of the Drosophila airways...
  27. ncbi MAP kinase in situ activation atlas during Drosophila embryogenesis
    L Gabay
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Development 124:3535-41. 1997
    ..Since the antibody was raised against the phosphorylated form of a conserved ERK peptide containing the TEY motif, this approach is applicable to a wide spectrum of multicellular organisms...
  28. pmc Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling
    Susumu Hirabayashi
    Department of Developmental and Regenerative Biology, Annenberg 25 40, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Place, Box 1020, New York, NY 10029, USA
    Cell 154:664-75. 2013
    ..By targeting multiple steps in this circuit with rationally applied drug combinations, we demonstrate the potential of combinatorial drug intervention to treat diet-enhanced malignant tumors. ..
  29. ncbi DPP controls tracheal cell migration along the dorsoventral body axis of the Drosophila embryo
    S Vincent
    Abteilung Zellbiologie, Biozentrum, Universitat Basel, Switzerland
    Development 124:2741-50. 1997
    ..developing tracheal placode, and is also required for the dorsal expression of the recently identified BRANCHLESS (BNL) guidance molecule, the ligand of the BREATHLESS (BTL) receptor...
  30. doi The ETS domain transcriptional repressor Anterior open inhibits MAP kinase and Wingless signaling to couple tracheal cell fate with branch identity
    Sara Caviglia
    Institute of Molecular Life Sciences and PhD Program in Molecular Life Sciences, University of Zurich, Winterthurer Str 190, CH 8057 Zurich, Switzerland
    Development 140:1240-9. 2013
    ..The switch from a branching towards an anastomosing tip cell type may have evolved with the acquisition of a main tube that connects separate tracheal primordia to generate a tubular network...
  31. ncbi Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea
    T Ikeya
    Genetic Strains Research Center and The Graduate University for Advanced Studies, National Institute of Genetics, Mishima 411 8540, Japan
    Development 126:4455-63. 1999
    The patterned branching in the Drosophila tracheal system is triggered by the FGF-like ligand Branchless that activates a receptor tyrosine kinase Breathless and the MAP kinase pathway...
  32. ncbi The transcription factors KNIRPS and KNIRPS RELATED control cell migration and branch morphogenesis during Drosophila tracheal development
    C K Chen
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Am Fassberg, D 37077 Gottingen, Germany
    Development 125:4959-68. 1998
    ..Furthermore, we provide evidence that the border between cells acquiring dorsal branch and dorsal trunk identity is established by the direct interaction of KNIRPS with a spalt cis-regulatory element...
  33. ncbi adrift, a novel bnl-induced Drosophila gene, required for tracheal pathfinding into the CNS
    C Englund
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187 Umea, Sweden
    Development 126:1505-14. 1999
    ..and is expressed in the leading cells of migrating ganglionic branches where it is induced by the branchless FGF pathway...
  34. pmc Specificity of Drosophila cytonemes for distinct signaling pathways
    Sougata Roy
    Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA
    Science 332:354-8. 2011
    ..Tracheal cells had at least two types: one made in response to Branchless (a Drosophila fibroblast growth factor protein, Bnl), to which they segregate the Bnl receptor, and another to which they segregate the Dpp receptor...
  35. doi The Drosophila homologue of SRF acts as a boosting mechanism to sustain FGF-induced terminal branching in the tracheal system
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Parc Cientific de Barcelona, c Baldiri Reixac, 10 12, 08028 Barcelona, Spain
    Development 138:1269-74. 2011
    ..have demonstrated a crucial role for the transcription factor SRF (serum response factor) downstream of VEGF and FGF signalling during branching morphogenesis...
  36. pmc The bHLH transcription factor, hairy, refines the terminal cell fate in the Drosophila embryonic trachea
    Yaoyao Zhan
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 5:e14134. 2010
    ..Although hairy was shown to be expressed in the tracheal primordia and in surrounding mesoderm, whether hairy plays a role in tracheal development is not known...
  37. ncbi Genetic control of branching morphogenesis
    R J Metzger
    Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Science 284:1635-9. 1999
    ..In both the developing Drosophila tracheal (respiratory) system and mammalian lung, a fibroblast growth factor (FGF) signaling pathway is reiteratively used to pattern successive rounds of branching...
  38. ncbi Dpp and Notch specify the fusion cell fate in the dorsal branches of the Drosophila trachea
    P Steneberg
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187, Umea, Sweden
    Mech Dev 87:153-63. 1999
    ....
  39. ncbi The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development
    D J Montell
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Development 126:3035-46. 1999
    ..In addition, receptor tyrosine kinases (RTKs), and FGF receptors in particular, have emerged as key mediators of cell migration in vivo, confirming the importance of ..
  40. doi Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis
    Qiong Wang
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Cell 18:157-64. 2010
    b>FGF signaling is a central regulator of branching morphogenesis processes, such as angiogenesis or the development of branched organs including lung, kidney, and mammary gland...
  41. doi Manipulation of gene expression by infrared laser heat shock and its application to the study of tracheal development in Drosophila
    Guangxia Miao
    Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Hyogo, Japan Department of Biology, Kobe University Graduate School of Science, Nada Ku, Kobe, Hyogo, Japan
    Dev Dyn 244:479-87. 2015
    ..2009) in the Drosophila embryo. In this technique, infrared laser light illumination induces genes to be expressed under the control of heat shock promoters at the single cell level...
  42. ncbi Signaling systems, guided cell migration, and organogenesis: insights from genetic studies in Drosophila
    Carlos Ribeiro
    Biozentrum der Universitat Basel, Department of Cell Biology, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Biol 260:1-8. 2003
    ....
  43. pmc Cytoneme-mediated contact-dependent transport of the Drosophila decapentaplegic signaling protein
    Sougata Roy
    Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
    Science 343:1244624. 2014
    ....
  44. pmc The archipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression
    Nathan T Mortimer
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS Genet 9:e1003314. 2013
    ..the HIF-1α subunit of the hypoxia-inducible transcription factor dHIF and its target the FGF ligand branchless (bnl), and is enhanced by depletion of the Drosophila Von Hippel Lindau (dVHL) factor, which is a subunit of an oxygen-..
  45. pmc HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogaster
    Yan Li
    Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
    PLoS Genet 9:e1003230. 2013
    ..These results indicate that competent hypoxic responses arise from complex interactions between HIF-dependent and -independent mechanisms, and that dERR plays a central role in both of these programs...
  46. pmc FGF coordinates air sac development by activation of the EGF ligand Vein through the transcription factor PntP2
    Josefa Cruz
    Institute of Evolutionary Biology IBE, CSIC Universitat Pompeu Fabra, P de la Barceloneta 37, 08003 Barcelona, Catalonia, Spain
    Sci Rep 5:17806. 2015
    ..The ASP emerges from the tracheal branch that connects to the wing disc by the activation of both Bnl-FGF/Btl and EGFR signaling pathways. Together, these pathways promote cell migration and proliferation...
  47. pmc Drosophila tracheal system formation involves FGF-dependent cell extensions contacting bridge-cells
    Christian Wolf
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Am Fassberg, D 37077 Gottingen, Germany
    EMBO Rep 3:563-8. 2002
    ..The results of both dominant-negative and gain-of-function experiments suggest that the formation of cell extensions require Cdc42-mediated Drosophila fibroblast growth factor activity.
  48. doi Sequoia establishes tip-cell number in Drosophila trachea by regulating FGF levels
    Sofia J Araújo
    Institut de Biologia Molecular de Barcelona, Parc Cientific de Barcelona, C Baldiri Reixac 10, 08028 Barcelona, Spain
    J Cell Sci 124:2335-40. 2011
    ..We identify Sequoia (Seq) as a negative transcriptional regulator of Branchless (Bnl), a Drosophila FGF homologue, and observe that modulation of Bnl levels determines how many cells will lead this ..
  49. pmc The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development
    Hélène Chanut-Delalande
    Biozentrum der Universitat Basel, Abteilung Zellbiologie, Basel, Switzerland
    PLoS ONE 5:e10245. 2010
    ..This suggest that Stam, putatively within the ESCRT-0 complex, modulates FGF signalling, a possibility that has not been examined in Drosophila yet.
  50. pmc A signaling network for patterning of neuronal connectivity in the Drosophila brain
    Mohammed Srahna
    Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Leuven School of Medicine, Leuven, Belgium
    PLoS Biol 4:e348. 2006
    ..in the developing adult brain of Drosophila and find that it is regulated by crosstalk between Wnt, fibroblast growth factor (FGF) receptor, and Jun N-terminal kinase (JNK) signaling, but independent of neuronal activity...
  51. pmc Shaping leg muscles in Drosophila: role of ladybird, a conserved regulator of appendicular myogenesis
    Tariq Maqbool
    Institut National de la Santé et de la Recherche Médicale U384, Faculte de Medecine, Clermont Ferrand, France
    PLoS ONE 1:e122. 2006
    ..In addition, ladybird expression correlates with that of FGF receptor Heartless and the read-out of FGF signalling downstream of FGF...
  52. ncbi Tissue-specific laminin expression facilitates integrin-dependent association of the embryonic wing disc with the trachea in Drosophila
    Yoshiko Inoue
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo ku Kobe 650 0047, Japan
    Dev Biol 304:90-101. 2007
    ..Our data identify Wb laminin as an extracellular matrix ligand that is essential for integrin-dependent cellular migration in Drosophila...
  53. pmc Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network
    Janus S Jakobsen
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Genes Dev 21:2448-60. 2007
    ..The regulatory connection of a number of Biniou target genes is conserved in mice, suggesting an ancient wiring of this developmental program...
  54. ncbi FGFs, heparan sulfate and FGFRs: complex interactions essential for development
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Bioessays 22:108-12. 2000
    ..biochemical and cellular evidence points to a direct role for heparin/heparan sulfate in the formation of an active FGF/FGF receptor signaling complex...
  55. pmc The Drosophila Perlecan gene trol regulates multiple signaling pathways in different developmental contexts
    Jonathan R Lindner
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, 77843 2128, USA
    BMC Dev Biol 7:121. 2007
    ..The Drosophila Perlecan homolog trol has been shown to regulate the activity of Hedgehog and Branchless (an FGF homolog) to control the onset of stem cell proliferation in the developing brain during first instar...
  56. ncbi Pictures in cell biology. Cytonemes
    T Kornberg
    Dept of Biochemistry and Biophysics, University of California School of Medicine, San Francisco, CA 94143, USA
    Trends Cell Biol 9:434. 1999
  57. pmc Genes regulating dendritic outgrowth, branching, and routing in Drosophila
    F B Gao
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California at San Francisco, San Francisco, California 94143 0725, USA
    Genes Dev 13:2549-61. 1999
    ..These findings begin to reveal the molecular mechanisms controlling dendritic morphogenesis...
  58. ncbi Filopodia: fickle fingers of cell fate?
    P J Bryant
    Developmental Biology Center, University of California, Irvine, California 92697, USA
    Curr Biol 9:R655-7. 1999
    ..Do they function in morphogenesis, cell-cell signaling or both?...
  59. ncbi Sex-specific deployment of FGF signaling in Drosophila recruits mesodermal cells into the male genital imaginal disc
    Shaad M Ahmad
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 109:651-61. 2002
    ..We show that Drosophila FGF is used, only in males, to recruit mesodermal cells expressing its receptor to become part of the genital imaginal ..
  60. ncbi Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs
    F A Ramirez-Weber
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
    Cell 97:599-607. 1999
    ..the lateral flanks of a wing disc are cultured next to cells from the A/P border or next to a source of fibroblast growth factor. Mouse limb bud cells also grow projections during a brief culture period, indicating that cytonemes are ..
  61. ncbi Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila
    S Kramer
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 126:2515-25. 1999
    Extracellular factors such as FGF and EGF control various aspects of morphogenesis, patterning and cellular proliferation in both invertebrates and vertebrates...
  62. pmc Fibroblast growth factor signalling controls successive cell behaviours during mesoderm layer formation in Drosophila
    Ivan B N Clark
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Development 138:2705-15. 2011
    b>Fibroblast growth factor (FGF)-dependent epithelial-mesenchymal transitions and cell migration contribute to the establishment of germ layers in vertebrates and other animals, but a comprehensive demonstration of the cellular activities ..
  63. ncbi Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila
    A M Michelson
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Development 125:4379-89. 1998
    Drosophila possesses two FGF receptors which are encoded by the heartless and breathless genes...
  64. ncbi Localized activation of RTK/MAPK pathways during Drosophila development
    E Bier
    Department of Biology, University of California, San Diego, La Jolla 92093 0349, USA
    Bioessays 20:189-94. 1998
    ..The ability to visualize the output of RTK signaling also permits detailed establishment of epistatic relationships between signaling components of RTK cascades...
  65. ncbi Branching morphogenesis in the Drosophila tracheal system
    B Z Shilo
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Cold Spring Harb Symp Quant Biol 62:241-7. 1997
  66. ncbi Genes that control organ form: lessons from bone and branching morphogenesis
    M A Krasnow
    Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5307, USA
    Cold Spring Harb Symp Quant Biol 62:235-40. 1997
  67. pmc The tracheae defective gene encodes a bZIP protein that controls tracheal cell movement during Drosophila embryogenesis
    K G Eulenberg
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Am Fassberg 11, 37070 Gottingen, Germany
    EMBO J 16:7156-65. 1997
    ..In contrast, tdf activity is not dependent on and does not interfere with the fibroblast growth factor- (FGF) and Decapentaplegic- (DPP) mediated signalling that direct guided tracheal cell migration...
  68. pmc Tube morphogenesis: closure, but many openings remain
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305 5435, USA
    Trends Cell Biol 13:615-21. 2003
    ..This review provides a summary of these pathways based upon articles published in the Tube Morphogenesis Series in Trends in Cell Biology...
  69. ncbi The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis
    K Shim
    Howard Hughes Medical Institute and Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
    Development 128:4923-33. 2001
    ..rib mutant tracheal cells are still responsive to the Branchless fibroblast growth factor (FGF) that guides branch outgrowth, and they express apical membrane markers normally...
  70. ncbi Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution
    H G Nagendra
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, CB2 1GA, Cambridge, UK
    FEBS Lett 501:51-8. 2001
    ..multiple splice forms of their receptors (FGFRs) in higher vertebrates makes the three-dimensional (3D) analysis of FGF interactions with their receptors a formidable task...
  71. ncbi spalt-induced specification of distinct dorsal and ventral domains is required for Drosophila tracheal patterning
    Xavier Franch-Marro
    Institut de Biologia Molecular de Barcelona CSIC, C Jordi Girona 18 26, 08034 Barcelona, Spain
    Dev Biol 250:374-82. 2002
    ..These results indicate that tracheal patterning depends not only on signalling from surrounding cells but also in the different response of the tracheal cells depending on their allocation to the dorsal or ventral domains...
  72. ncbi Cell migration in invertebrates: clues from border and distal tip cells
    R Lehmann
    Developmental Genetics Program, Skirball Institute and Howard Hughes Medical Institute, Department of Cell Biology, New York University Medical School, 540 First Avenue, New York 10016, New York, USA
    Curr Opin Genet Dev 11:457-63. 2001
    ..Finally, Dock180, CrkII and the GTPase Rac link the extracellular signals to the cellular machinery that controls cell motility...
  73. ncbi Sex comes in from the cold: the integration of sex and pattern
    Audrey E Christiansen
    Department Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Trends Genet 18:510-6. 2002
    ..Most significantly, the sex hierarchy has been shown to modulate the activities of well-known signaling molecules (FGF, Wnt and TGF beta proteins) and transcription factors (BAB and DAC) to direct various sex-specific aspects of ..
  74. ncbi Do different branching epithelia use a conserved developmental mechanism?
    Jamie A Davies
    Anatomy Building, Edinburgh University Medical School, Scotland
    Bioessays 24:937-48. 2002
    ..Overall, I come to the tentative conclusion that key mechanisms are highly conserved, at least within vertebrates, but acknowledge that more work needs to be done before the case is proved beyond reasonable doubt...
  75. ncbi Embryo morphogenesis: getting down to cells and molecules
    Lila Solnica-Krezel
    Vanderbilt University, VU Station B 351634, Nashville, TN 37235 1634, USA
    Development 130:4229-33. 2003
  76. ncbi Modulation of signalling by Sprouty: a developing story
    Hong Joo Kim
    Graduate Program in Molecular and Cellular Biology, State University of New York, Stony Brook, New York 11794 5222, USA
    Nat Rev Mol Cell Biol 5:441-50. 2004
  77. ncbi Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
    Lolitika Mandal
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Genet 36:1019-23. 2004
    ..and the homeobox gene tinman (tin), which are controlled by the convergence of Decapentaplegic (Dpp), fibroblast growth factor (FGF), Wingless (Wg) and Notch signaling, are required for the development of all cardiogenic mesoderm, ..
  78. ncbi The alternative migratory pathways of the Drosophila tracheal cells are associated with distinct subsets of mesodermal cells
    X Franch-Marro
    Institut de Biologia Molecular de Barcelona, C Jordi Girona 18 26, Barcelona, 08034, Spain
    Dev Biol 227:80-90. 2000
    ..These results show how adjacent tissues influence morphogenesis of the tracheal system and offer a model for understanding how organ formation is determined by its genetic program and by the surrounding topological constraints...
  79. pmc A molecular link between FGF and Dpp signaling in branch-specific migration of the Drosophila trachea
    Monn Monn Myat
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Biol 281:38-52. 2005
    ..embryos achieves its archetypal branching pattern through a series of cell migration events requiring the FGF, Dpp, and Wg/WNT signaling pathways...
  80. ncbi Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases
    Lesley A Jarvis
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5307 USA
    Development 133:1133-42. 2006
    ..We propose that this double-negative feedback circuit shapes the output profile of RTK signaling events...
  81. ncbi Morphogenesis: FGF branches out
    H Skaer
    Department of Anatomy, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK
    Curr Biol 7:R238-41. 1997
    Signalling via tissue-specific receptors for fibroblast growth factor is important in tracheal branching and mesodermal patterning in Drosophila; both processes may involve a common primary response - detachment and directed migration of ..
  82. ncbi Fly gene discovery gets at root of branching structures
    W Roush
    Science 274:2011. 1996
  83. ncbi Development. Doublesex in the middle
    Kenneth C Burtis
    Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Science 297:1135-6. 2002
  84. ncbi Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis
    Cindy Krause
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg, D 37077 Gottingen, Germany
    Dev Biol 296:253-64. 2006
    ..We propose that Capricious contributes to the instructive role of bridge-cells whereas Tartan provides permissive substrate for the migrating tracheal cells during the network formation...
  85. ncbi Heparan sulfate fine structure and specificity of proteoglycan functions
    Hiroshi Nakato
    Department of Molecular and Cellular Biology, and Arizona Cancer Center, University of Arizona, Tucson 85724, USA
    Biochim Biophys Acta 1573:312-8. 2002
    ..In this review, we focus on the molecular basis of growth factor control by the sulfation status of heparan sulfate...
  86. ncbi Gal4 in the Drosophila female germline
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, 115 West University Parkway, Baltimore, MD 21210, USA
    Mech Dev 78:113-8. 1998
    ..The modified Gal4 system was used to investigate the role of the Drosophila FGF homologue branchless, ligand for the FGF receptor breathless, in border cell migration...
  87. ncbi EGF signalling regulates cell invagination as well as cell migration during formation of tracheal system in Drosophila
    M Llimargas
    Centre d Investigació i Desenvolupament CSIC, C Jordi Girona 18 26, E 08034 Barcelona, Spain
    Dev Genes Evol 209:174-9. 1999
    ..We discuss how the consecutive steps of tracheal morphogenesis might affect the final branching pattern...
  88. ncbi Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila
    Takahiro Chihara
    Department of Genetics, Graduate University for Advanced Studies, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka ken 411 8540 Japan
    Development 130:1419-28. 2003
    ..Together with its role in cell motility, Rac regulates plasticity of cell adhesion and thus ensures smooth remodeling of epithelial sheets into tubules...
  89. pmc piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila
    Udo Hacker
    Department of Cell and Molecular Biology, BMC B13, Lund University, 22184 Lund, Sweden
    Proc Natl Acad Sci U S A 100:7720-5. 2003
    ..Our data demonstrate the potential of this technique to facilitate the quest for saturation mutagenesis of the Drosophila genome. The system is Drosophila nonspecific and potentially applicable in a broad spectrum of nonmodel organisms...
  90. ncbi Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development
    X Lin
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 126:3715-23. 1999
    ..Biochemical studies have shown that heparan sulfate glycosaminoglycans are involved in signaling by fibroblast growth factor receptors, but evidence for such a requirement in an intact organism has not been available...
  91. pmc Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm
    R Wilson
    Institute of Genetics, University of Cologne, Germany
    Philos Trans R Soc Lond B Biol Sci 355:891-5. 2000
    The Drosophila fibroblast growth factor (FGF) receptors Heartless and Breathless are required for the morphogenesis of the mesoderm and the tracheal system...
  92. ncbi Cells in search of a signal
    G Morata
    Nat Cell Biol 1:E60-1. 1999
  93. ncbi Cell fate choices in Drosophila tracheal morphogenesis
    E Zelzer
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Bioessays 22:219-26. 2000
    ..Localized presentation of the FGF ligand, Branchless, to tracheal cells that express the FGF receptor, Breathless, guides migration...

Research Grants8

  1. HEDGEHOG SIGNALING IN DEVELOPMENT AND DISEASE
    Thomas Kornberg; Fiscal Year: 2009
    ....
  2. THE DROSOPHILA DORSAL AIR SACS, A MODEL SYSTEM FOR LUNG DEVELOPMENT
    Thomas B Kornberg; Fiscal Year: 2010
    ..Our work has shown that Bnl-FGF induces this large, complex and multi-lobed tracheal organ which functions in ways that are analogous to the ..
  3. SYNAPSE STRUCTURE AND DEVELOPMENT
    W Nelson; Fiscal Year: 2001
    ..This research will aid in the prevention of psychiatric illness and the development of therapies for afflicted individuals. ..
  4. GENETIC CONTROL OF THE YEAST SPORULATION PROGRAM
    Thomas Kornberg; Fiscal Year: 2003
    ..Learning about Ndt80 protein is likely to yield enormous insight on the decision to exit meiotic prophase and on the overall program of sporulation. ..
  5. Cytoskeleton Coordination in Neuronal Morphogenesis
    W Nelson; Fiscal Year: 2005
    ....
  6. Model Organisms and Approaches in Developmental Biology
    Ruth Lehmann; Fiscal Year: 2005
    ..3) Providing an open forum for discussion on current topics in developmental biology of relevance to education and science policy in the participating countries and the Western Hemisphere. ..
  7. Regulation of Cell Migration by the APC-Microtubule Complex
    William Nelson; Fiscal Year: 2009
    ..abstract_text> ..