beat-Ia

Summary

Gene Symbol: beat-Ia
Description: beaten path Ia
Alias: BG:DS00913.3, Beat Ia, Beat-Ia, CCT, CG4846, CT15567, Cct, Dmel\CG4846, TRiC, beat, beat Ia, beat1a, l(2)35Ea, l(2)35Eb, l(2)br47, l(2)br48, tric, CG4846 gene product from transcript CG4846-RB, CG4846-PA, CG4846-PB, beat-Ia-PA, beat-Ia-PB, beaten path, chaperonin containing TCP-1, triclops
Species: fruit fly

Top Publications

  1. pmc A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection
    Aref Arzan Zarin
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Neuron 81:1297-311. 2014
  2. pmc Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila
    Crystal M Miller
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 31:5335-47. 2011
  3. ncbi Plexin A is a neuronal semaphorin receptor that controls axon guidance
    M L Winberg
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 95:903-16. 1998
  4. pmc Drosophila motor axons recognize and follow a Sidestep-labeled substrate pathway to reach their target fields
    Matthias Siebert
    Westfalische Wilhelms Universitat Munster, Institut fur Neurobiologie, Munster, Germany
    Genes Dev 23:1052-62. 2009
  5. ncbi The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster
    Oliver Hobert
    Development 131:2237-8; author reply 2238-40. 2004
  6. ncbi The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule in Drosophila
    G C Pipes
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, 519 LSA, University of California, Berkeley, CA 94720, USA
    Development 128:4545-52. 2001
  7. pmc Ab initio gene finding in Drosophila genomic DNA
    A A Salamov
    The Sanger Centre, Hinxton, Cambridge CB10 1SA, UK
    Genome Res 10:516-22. 2000
  8. ncbi Muscle founder cells regulate defasciculation and targeting of motor axons in the Drosophila embryo
    M Landgraf
    Department of Zoology, Downing Street, Cambridge, CB2 3EJ, UK
    Curr Biol 9:589-92. 1999
  9. ncbi Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development
    A Chiba
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign 61801, USA
    Int Rev Neurobiol 43:1-24. 1999
  10. ncbi Neuronal guidance. A genetic perspective
    G Tear
    Department of Biochemistry, Imperial College, London, UK
    Trends Genet 15:113-8. 1999

Scientific Experts

  • Guy Tear
  • M Landgraf
  • P Lasko
  • Aref Arzan Zarin
  • Crystal M Miller
  • C S Goodman
  • Matthias Siebert
  • A L Holmes
  • Oliver Hobert
  • D Van Vactor
  • Karsten Hokamp
  • Jamshid Asadzadeh
  • Juan Pablo Labrador
  • Daniel McCartney
  • Long Yang
  • Greg J Bashaw
  • G C Pipes
  • Nan Liu
  • Heather T Broihier
  • Andrea Page-McCaw
  • A A Salamov
  • Daniel Banovic
  • Bernd Goellner
  • Hermann Aberle
  • D Fambrough
  • A Chiba
  • J S Heilig
  • M L Winberg
  • N Kaufmann
  • Richard O Hynes
  • J F Bazan
  • A R Mushegian
  • Harald Hutter
  • A Nakamura
  • S E Riley
  • Q Lin
  • V V Solovyev
  • M Tessier-Lavigne
  • M A Seeger
  • J N Noordermeer
  • A M O'Reilly
  • R N Raper
  • Z P Wills
  • M K Spriggs
  • L Tamagnone
  • B G Neel
  • P M Comoglio
  • M Mukai
  • D V Vactor
  • R Amikura
  • K Broadie
  • S Kobayashi
  • H Sink
  • P M Whitington
  • M Bate
  • R Tsoo

Detail Information

Publications22

  1. pmc A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection
    Aref Arzan Zarin
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    Neuron 81:1297-311. 2014
    ..Finally, we show that a network of TFs, comprised of eve, zfh1, and grain, induces the expression of the Unc5 and Beaten-path guidance receptors and the Fasciclin 2 and Neuroglian adhesion molecules to guide individual dMN axons. ..
  2. pmc Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila
    Crystal M Miller
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 31:5335-47. 2011
    ..Indeed, we present genetic evidence that Frac regulates a non-canonical LIM kinase 1-dependent bone morphogenetic protein signaling pathway in motoneurons necessary for axon pathfinding during embryogenesis...
  3. ncbi Plexin A is a neuronal semaphorin receptor that controls axon guidance
    M L Winberg
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 95:903-16. 1998
    ..Plexins, which themselves contain complete Semaphorin domains, may be both the ancestors of classical Semaphorins and binding partners for Semaphorins...
  4. pmc Drosophila motor axons recognize and follow a Sidestep-labeled substrate pathway to reach their target fields
    Matthias Siebert
    Westfalische Wilhelms Universitat Munster, Institut fur Neurobiologie, Munster, Germany
    Genes Dev 23:1052-62. 2009
    ..We provide evidence that, on motor axons, Beaten path Ia (Beat) functions as a receptor or part of a receptor complex for Side...
  5. ncbi The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster
    Oliver Hobert
    Development 131:2237-8; author reply 2238-40. 2004
  6. ncbi The Beat generation: a multigene family encoding IgSF proteins related to the Beat axon guidance molecule in Drosophila
    G C Pipes
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, 519 LSA, University of California, Berkeley, CA 94720, USA
    Development 128:4545-52. 2001
    A previous genetic screen led to the identification of the beaten path (beat Ia) gene in Drosophila...
  7. pmc Ab initio gene finding in Drosophila genomic DNA
    A A Salamov
    The Sanger Centre, Hinxton, Cambridge CB10 1SA, UK
    Genome Res 10:516-22. 2000
    ..The suite of gene identification programs is available through the WWW server of Computational Genomics Group at http://genomic.sanger.ac.uk/gf. html...
  8. ncbi Muscle founder cells regulate defasciculation and targeting of motor axons in the Drosophila embryo
    M Landgraf
    Department of Zoology, Downing Street, Cambridge, CB2 3EJ, UK
    Curr Biol 9:589-92. 1999
    ..This suggests that the muscle field is structured into sets of muscles, each expressing a common defasciculation cue for a particular nerve branch...
  9. ncbi Early development of the Drosophila neuromuscular junction: a model for studying neuronal networks in development
    A Chiba
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign 61801, USA
    Int Rev Neurobiol 43:1-24. 1999
  10. ncbi Neuronal guidance. A genetic perspective
    G Tear
    Department of Biochemistry, Imperial College, London, UK
    Trends Genet 15:113-8. 1999
    ..Here I highlight the part genetic screens and analyses have played in revealing some of the key players in neuronal guidance...
  11. ncbi even-skipped determines the dorsal growth of motor axons in Drosophila
    M Landgraf
    Department of Zoology, University of Cambridge, United Kingdom
    Neuron 22:43-52. 1999
    ..Thus, even-skipped complements the function of islet, and together these two genes constitute a bimodal switch regulating axonal growth and directing motor axons to ventral or to dorsal regions of the muscle field...
  12. ncbi From growth cone to synapse: the life history of the RP3 motor neuron
    K Broadie
    Department of Zoology, University of Cambridge, UK
    Dev Suppl . 1993
    ..Genetic analysis has revealed mutations in a number of different genes which affect specific aspects of RP3 development from axon outgrowth to synapse formation...
  13. ncbi Fasciclin II and Beaten path modulate intercellular adhesion in Drosophila larval visual organ development
    A L Holmes
    Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309 0347, USA
    Development 126:261-72. 1999
    Previous studies demonstrated that Fasciclin II and Beaten path are necessary for regulating cell adhesion events that are important for motoneuron development in Drosophila...
  14. pmc Genetic analysis of Drosophila larval optic nerve development
    A L Holmes
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
    Genetics 148:1189-201. 1998
    ..These mutants and phenotypic classifications provide a context for further analysis of neuronal development, pathfinding and target recognition...
  15. ncbi Genetic analysis of protein tyrosine phosphatases
    D Van Vactor
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 8:112-26. 1998
    ..Finally, very recent studies of other mammalian PTPs suggest that they have critical roles in processes as diverse as hematopoiesis and liver and pituitary development...
  16. ncbi Drosophila Rac1 controls motor axon guidance
    N Kaufmann
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115 5730, USA
    Development 125:453-61. 1998
    ..Genetic interactions between Drac1(N17) and the receptor-tyrosine phosphatase Dlar suggest that intersegmental nerve b guidance requires the integration of multiple, convergent signals...
  17. ncbi Modular structure of the Drosophila Beat protein
    J F Bazan
    Curr Biol 7:R338-9. 1997
  18. ncbi The Drosophila Beat protein is related to adhesion proteins that contain immunoglobulin domains
    A R Mushegian
    Curr Biol 7:R336-8. 1997
  19. ncbi The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points
    D Fambrough
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 87:1049-58. 1996
    ..Here we describe the analysis of beaten path (beat), a gene required for the selective defasciculation of motor axons at these choice points...
  20. ncbi Requirement for a noncoding RNA in Drosophila polar granules for germ cell establishment
    A Nakamura
    Department of Biology, McGill University, Montr eal, Qu ebec H3A 1B1, Canada
    Science 274:2075-9. 1996
    ..These results support an essential role for Pgc RNA in germline development...
  21. ncbi Genes that control neuromuscular specificity in Drosophila
    D V Vactor
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 73:1137-53. 1993
    ..We focus on 5 genes required for specific aspects of pathway (beaten path, stranded, and short stop) and target (walkabout and clueless) recognition...
  22. ncbi Genetic and molecular dissection of axon pathfinding in the Drosophila nervous system
    M A Seeger
    Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104 5073
    Curr Opin Neurobiol 4:56-62. 1994
    ....