Genomes and Genes
Gene Symbol: ase
Alias: AS-C T8, AS-C T8ase, AS-T8, ASC, Ase, CG3258, Dmel\CG3258, EG:165H7.2, T1A, T1a, as-T8, ascT8, bHLHc28, sc/T8, CG3258 gene product from transcript CG3258-RA, CG3258-PA, ase-PA
Species: fruit fly
Publications111 found, 100 shown here
- asense is a Drosophila neural precursor gene and is capable of initiating sense organ formationM Brand
Howard Huges Medical Institute, University of California, San Francisco, CA 94143 0724, USA
Development 119:1-17. 1993..Our studies therefore serve as a cautionary note for the inference of normal gene function based on the gain-of-function phenotype after ectopic expression...
- Patterning of the Drosophila nervous system: the achaete-scute gene complexS Campuzano
Centro de Biologia Molecular, CSIC, Madrid, Spain
Trends Genet 8:202-8. 1992..Neuroblasts or sensory organ mother cells are born within these clusters. Thus, the patterns of expression of the AS-C genes help to define the topology of the nervous system...
- prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in DrosophilaH Vaessin
Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
Cell 67:941-53. 1991..prospero encodes a large nuclear protein with multiple homopolymeric amino acid stretches and is expressed in neuronal precursors early during their formation. It is probably generally required for proper neuronal differentiation...
- The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genesM C Alonso
MRC Laboratory of Molecular Biology, Cambridge, UK
EMBO J 7:2585-91. 1988..We discuss the possible biochemical function of the AS-C in neurogenesis in the light of the homologies of the four genes with the mammalian myc family...
- Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe developmentF Gonzalez
Centro de Biologia Molecular, Universidad Autonoma de Madrid, Canto Blanco, Spain
EMBO J 8:3553-62. 1989..It comprises 22 kb of DNA and contains two transcription units, only one of which, named asense (ase), seems involved in neurogenesis...
- daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryoH Vaessin
Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
Development 120:935-45. 1994..da is not required for the initial appearance of nascent neuronal precursors but is required for these cells to express multiple neuronal precursor genes and to produce the normal number of neurons...
- Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discsJ L Gomez-Skarmeta
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
Genes Dev 9:1869-82. 1995..Our data indicate that coexpression is accomplished by activation of both ac and sc by the same set of position-specific enhancers...
- The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genesU Hinz
Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
Cell 76:77-87. 1994..Finally, the bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition...
- Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in DrosophilaP Heitzler
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, Strasbourg, France
Development 122:161-71. 1996..Thus there is a regulatory loop between Notch and Delta that is under the transcriptional control of the E(spl)-C and AS-C genes...
- inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor proteinR Kraut
Institut fur Entwicklungsbiologie, Universitat zu Koln, Cologne, Germany
Dev Biol 174:65-81. 1996..The inscuteable mutant phenotype, together with these other observations, suggests a possible role for the protein in cytoskeleton organization...
- Control of daughter cell fates during asymmetric division: interaction of Numb and NotchM Guo
Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
Neuron 17:27-41. 1996..This leads to Ttk expression in the daughter cell that does not inherit Numb. Thus, the inherited determinant Numb bestows a bias in the machinery for cell-cell communication to allow the specification of distinct daughter cell fates...
- Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signalingJ Culi
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Genes Dev 12:2036-47. 1998..These data suggest a mechanism for SMC committment...
- The specificity of proneural genes in determining Drosophila sense organ identityA P Jarman
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
Mech Dev 76:117-25. 1998....
- Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursorsP zur Lage
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
Development 126:3149-57. 1999..SOP recruitment is reiterative because the inductive signal comes from previously recruited SOPs...
- Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblastsM Schober
Research Institute of Molecular Pathology, Vienna, Austria
Nature 402:548-51. 1999..Our results suggest that direct binding to Bazooka mediates the asymmetric localization of Inscuteable and connects the asymmetric division of neuroblasts to the axis of epithelial apical-basal polarity...
- The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobesK Wallace
Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
Genesis 26:77-85. 2000..Thus, regulation of mitotic activity during optic lobe development may, at least in part, involve deadpan and asense mediated regulation of the cyclin dependent kinase inhibitor gene dacapo. genesis 26:77-85, 2000...
- cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organsS E Goulding
Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, United Kingdom
Dev Biol 221:120-31. 2000..Moreover, in prospero mutants, in which axon and dendrite outgrowth is defective, cato is strongly derepressed in the developing CNS...
- Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in DrosophilaR Nolo
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 102:349-62. 2000..Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs...
- Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous systemM Schaefer
Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
Cell 107:183-94. 2001..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types...
- Gene duplication at the achaete-scute complex and morphological complexity of the peripheral nervous system in DipteraNick Skaer
Dept of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Trends Genet 18:399-405. 2002..This probably coincided in time with gene duplication events, raising the possibility that an increase in gene copy number might have provided the flexibility necessary for more complex transcriptional regulation...
- Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetryRoger Albertson
Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, OR 97403, USA
Nat Cell Biol 5:166-70. 2003..We conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts...
- Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisionsNaoyuki Fuse
Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, Chuou ku, Kobe 650 0047, Japan
Curr Biol 13:947-54. 2003..Furthermore, the multiple equal cleavages of G beta mutant neuroblasts accompany neural defects; this finding suggests indispensable roles of eccentric division in assuring the stem cell properties of neuroblasts...
- Segment polarity and DV patterning gene expression reveals segmental organization of the Drosophila brainRolf Urbach
Institut fur Genetik, Universitat Mainz, D 55099 Mainz, Germany
Development 130:3607-20. 2003..The labral neuromere is confined to the posterior segmental compartment. Finally, similarities in the expression of DV patterning genes between the Drosophila and vertebrate brains are discussed...
- phyllopod is a target gene of proneural proteins in Drosophila external sensory organ developmentHaiwei Pi
Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
Proc Natl Acad Sci U S A 101:8378-83. 2004..Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation...
- An ancient transcriptional regulatory linkageMark Rebeiz
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093 0349, USA
Dev Biol 281:299-308. 2005..We suggest that the systematic identification of such ancient and conserved connections will be a powerful means of uncovering the primordial functions of transcription factors and signaling systems...
- Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobeBoris Egger
The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Neural Dev 2:1. 2007..In some tissues cell fate appears to dictate the type of cell division, whereas in other tissues it is thought that stochastic variation in spindle position dictates subsequent sibling cell fate...
- NF-kappaB/Rel-mediated regulation of the neural fate in DrosophilaSavita Ayyar
Department of Zoology, University of Cambridge, Cambridge, United Kingdom
PLoS ONE 2:e1178. 2007..We propose that this buffering of gene expression levels serves to keep the neuro-epithelium constantly poised for neurogenesis...
- Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STATTetsuo Yasugi
Laboratory of Pattern Formation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
Development 135:1471-80. 2008....
- The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in DrosophilaSarah K Bowman
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
Dev Cell 14:535-46. 2008..Our data describe a transit-amplifying lineage in the Drosophila nervous system and suggest that different vulnerabilities in intermediate cell types can affect the outcome of tumor suppressor loss in stem cell lineages...
- dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in DrosophilaMo Weng
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
Dev Cell 18:126-35. 2010..We conclude that Erm dependence functionally distinguishes intermediate neural progenitors from neuroblasts in the Drosophila larval brain, balancing neurogenesis with stem cell maintenance...
- Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewalKai Chen Chang
Temasek Life Sciences Laboratory, 1 Research Link, Singapore 117604
Dev Cell 19:778-85. 2010..Thus, reciprocal repression between Zif and aPKC act as a critical regulatory mechanism for establishing cell polarity and controlling neuroblast self-renewal...
- The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in DrosophilaBeatriz P San-Juán
Centro de Biología Molecular Severo Ochoa Consejo Superior Investigaciones Científicas, Universidad Autonoma de Madrid, Nicolas Cabrera 1, 28049, Madrid, Spain
Dev Biol 352:70-82. 2011..We show that in addition to dpn, Notch signaling must be regulating other genes during this process that act redundantly with dpn...
- Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in DrosophilaYingshi Ouyang
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
Development 138:2185-96. 2011..Reduction of Dronc activity facilitates ENF induced by phospho-Numb. Our findings uncover a molecular mechanism that regulates Numb activity and suggest a novel role for Dronc caspase in regulating neural stem cell homeostasis...
- An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblastsCheng Wang
Neuroscience and Behavioral Disorder Program, Duke National University of Singapore Graduate Medical School Singapore, Singapore, Singapore
Dev Cell 21:520-33. 2011..Our findings reveal that the centrosomal proteins Ana2 and Ctp regulate Mud function to orient the mitotic spindle during NB asymmetric division...
- Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasisTravis D Carney
Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
Dev Biol 361:137-46. 2012..These genes are excellent candidates for regulating neural progenitor self-renewal in Drosophila and mammals...
- Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brainsSijun Zhu
Department of Physiology, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:20615-20. 2011..are produced from type II neuroblasts (NBs, Drosophila neural stem cells), which lack the proneural protein Asense (Ase) but not from Ase-expressing type I NBs...
- klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast divisionQi Xiao
Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
Development 139:2670-80. 2012..These results led us to propose that multiple mechanisms converge to exert precise control of klu and distinguish a progenitor cell from its sibling stem cell during asymmetric neuroblast division...
- The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestineXiankun Zeng
Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
Development 140:3532-40. 2013..Our data uncover a unique mechanism whereby the commitment of stem cells to discrete lineages is coordinately regulated by chromatin-remodeling factors. ..
- midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in DrosophilaTravis D Carney
Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
Development 140:4155-64. 2013..We conclude that Mdlc plays an essential role in maintaining neuronal differentiation, raising the possibility that RNF113A regulates neuronal differentiation in the human CNS. ..
- asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation geneM Dominguez
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Spain
EMBO J 12:2049-60. 1993The asense (ase) gene of the achaete-scute complex (AS-C) is expressed in the precursors of all adult sensory organs (SOs), the sensory mother cells (SMCs) and in their immediate progeny...
- The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursorsA P Jarman
Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0724, USA
Development 119:19-29. 1993..asense differs from the other AS-C members in its expression pattern, regulation, mutant phenotype and some DNA-binding properities...
- Early neurogenesis of the Drosophila brainA Younossi-Hartenstein
Department of Cellular Molecular and Developmental Biology, University of California Los Angeles 90024, USA
J Comp Neurol 370:313-29. 1996..With respect to their position and the expression of the markers asense (ase) and seven-up (svp), 23 small groups of one to five neuroblasts each were identified...
- Adherens junctions inhibit asymmetric division in the Drosophila epitheliumB Lu
Howard Hughes Medical Institute and Department of Physiology, University of California at San Francisco, 94143 0725, USA
Nature 409:522-5. 2001..Our results indicate that neuroepithelial cells have all the necessary components to execute asymmetric division, but that this pathway is normally overridden by the planar polarity cue provided by adherens junctions...
- The development and evolution of bristle patterns in DipteraP Simpson
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, C U de Strasbourg, France u strasbg fr
Development 126:1349-64. 1999....
- Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of DrosophilaM Hoch
Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, FRG
Development 120:3439-50. 1994..We demonstrate that both stages in the differentiation of this cell are established by the same sequence of genetic interactions, which have not previously been shown to occur outside the neurogenic ectoderm...
- Lethal of scute requires overexpression of daughterless to elicit ectopic neuronal development during embryogenesis in DrosophilaB Giebel
Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
Mech Dev 63:75-87. 1997..Under the present conditions, lateral inhibition is thus dominant over the activity of proneural genes...
- neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila developmentE C Lai
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, 539 Life Sciences Addition, Berkeley, California 94720, USA
Dev Biol 231:217-33. 2001..Collectively, these data indicate a key role for neu in the reception of the lateral inhibitory signal during peripheral neurogenesis...
- Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous systemGregory Emery
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
Cell 122:763-73. 2005..Our results suggest that cells can regulate signaling pathways and influence their developmental fate by inhibiting the formation of individual endocytic compartments...
- The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in DrosophilaCiara M Gallagher
Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
Dev Cell 11:641-53. 2006..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs...
- Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesisMaria Monastirioti
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, 100 N Plastira St, 70013 Heraklion, Crete, Greece
Development 137:191-201. 2010..The availability of Hey as a Notch readout has allowed us to study Notch signalling during the genesis of secondary neurons in the larval central nervous system...
- The function and regulation of the bHLH gene, cato, in Drosophila neurogenesisPetra I zur Lage
Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK
BMC Dev Biol 10:34. 2010..cousin of atonal (cato) encodes one such factor that is expressed widely in the developing sensory nervous system of Drosophila. However, nothing definitive was known of its function owing to the lack of specific mutations...
- An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the CambrianSavita Ayyar
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
BMC Biol 8:127. 2010..First identified in Drosophila, the SOPE contains discrete binding sites for four regulatory factors. The SOPE of the Drosophila asense gene is situated in the 5' UTR...
- Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complexOmer Ali Bayraktar
Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
Neural Dev 5:26. 2010..In addition, we use 9D11 lineage tracing to show that type II lineages generate both small-field and large-field neurons within the adult central complex, a brain region required for locomotion, flight, and visual pattern memory...
- Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repressionIoanna Zarifi
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, and Department of Biology, University of Crete, Heraklion, Crete, Greece
Mol Cell Biol 32:4534-48. 2012..We present a mechanistic model on the interplay of these bHLH factors in the context of neural fate assignment...
- COPS: detecting co-occurrence and spatial arrangement of transcription factor binding motifs in genome-wide datasetsNati Ha
Centre for Organismal Studies COS Heidelberg, University of Heidelberg, Heidelberg, Germany
PLoS ONE 7:e52055. 2012..In sum, COPS is a fast, efficient and user-friendly tool mining statistically and biologically significant TFBS co-occurrences and therefore allows the identification of TFs that combinatorially regulate gene expression...
- Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in DrosophilaAlla Amcheslavsky
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell Rep 9:32-9. 2014..These results establish that enteroendocrine cells serve as an important link between diet and visceral muscle expression of an insulin-like growth factor to stimulate intestinal stem cell proliferation and tissue growth. ..
- Keeping intestinal stem cell differentiation on the TramtrackChenhui Wang
a National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing, China
Fly (Austin) 9:110-4. 2015..In this Extra View, we also provide a brief discussion of recent progress and remaining questions concerning EE cell specification in adult Drosophila midgut. ..
- The bHLH genes in neural developmentC Dambly-Chaudiere
Laboratoire de Neurogénétique, Unité 432 INSERM, Universite Montpellier II, France
Int J Dev Biol 42:269-73. 1998..In this review, we discuss the significance of this phenomenon in the case of the basic Helix-Loop-Helix (bHLH) proteins that are involved at different steps of the development of the peripheral nervous system (PNS) of Drosophila...
- The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless geneDaniel J Mckay
Department of Biochemistry and Molecular Biophysics, Integrated Program in Cellular, Molecular, Structural and Genetic Studies, Columbia University, 701 W 168th Street, HHSC 1104, New York, NY 10032, USA
Development 136:61-71. 2009..Together, these findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll...
- Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neuronsSuewei Lin
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
PLoS ONE 4:e8392. 2009..In sum, unf governs axonal morphogenesis of multiple MB neuron types, possibly through regulating neuronal subtype identity...
- Differential regulation of transcription through distinct Suppressor of Hairless DNA binding site architectures during Notch signaling in proneural clustersJohn W Cave
Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA
Mol Cell Biol 31:22-9. 2011....
- Ancestral and conserved cis-regulatory architectures in developmental control genesMark Rebeiz
Division of Biological Sciences CDB, University of California San Diego, La Jolla, CA 92093, USA
Dev Biol 362:282-94. 2012..We propose that these stable motif architectures have been conserved intact from a deep ancestor, in part because they mediate a special mode of regulation that cannot be supplied by the other, unstable motif instances...
- Cortical aPKC kinase activity distinguishes neural stem cells from progenitor cells by ensuring asymmetric segregation of NumbJill M Haenfler
Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
Dev Biol 365:219-28. 2012....
- The generation of cell diversity during early neurogenesis in DrosophilaC V Cabrera
Marie Curie Research Institute, Oxted, UK
Development 115:893-901. 1992
- The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethalJ B Duffy
Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
Genes Dev 5:2176-87. 1991..runt is distinguished from previously identified regulators of Sxl by its nonuniform role and by the absence of an identifiable helix-loop-helix (HLH) motif, indicating that the activation of Sxl is not controlled solely by HLH proteins...
- Role of helix-loop-helix proteins in Drosophila neurogenesisH Vaessin
Howard Hughes Medical Institute, University of California, San Francisco 94143
Cold Spring Harb Symp Quant Biol 55:239-45. 1990
- Molecular genetics of the achaete-scute gene complex of D. melanogasterS Campuzano
Cell 40:327-38. 1985..Two additional polyadenylated RNAs are transcribed from the achaete (1.1 kb) and yellow (1.9 kb) loci...
- Proneural genes influence gliogenesis in DrosophilaA Giangrande
Institut de Genetique et de Biologie Molecularie et Cellulaire, CNRS UPR6520 INSERM U 184 ULP, Illkirch, CU de Strasbourg, France
Development 121:429-38. 1995..These observations lead to the hypothesis that gliogenesis is induced by the presence of sensory organ cells, either the precursor or its progeny...
- Embryonic development of the stomatogastric nervous system in DrosophilaV Hartenstein
Department of Biology, University of California at Los Angeles 90024
J Comp Neurol 350:367-81. 1994..Both recurrent nerve and frontal connectives are pioneered by small subpopulations of early differentiating stomatogastric neurons that most likely derive from among the dSNSPs and iSNSPs...
- Neuronal cell fate specification in DrosophilaY N Jan
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco 94143 0724
Curr Opin Neurobiol 4:8-13. 1994..Selective expression of certain neuronal-type selector genes further specifies the type of neuron(s) that a neural precursor will produce...
- Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ developmentD F Lyman
Department of Biology, Emory University, Atlanta, Georgia 30322, USA dlyman biology emory edu
Genetics 141:1491-505. 1995..The results suggest that H insulates SOP cells from inhibition and indicate that H activity is suppressed by Notch signaling...
- The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regionsD Bettler
Department of Biology, Emory University, Atlanta, Georgia 30322, USA
Genetics 143:859-75. 1996..Immunohistochemical detection of Mam on polytene chromosomes revealed binding at > 100 sites. Chromosome colocalization studies with RNA polymerase and the groucho corepressor protein implicate Mam in transcriptional regulation...
- Persistent expression of genes of the enhancer of split complex suppresses neural development in DrosophilaK Nakao
Institut für Entwicklungsbiologie Universität zu Köln, Germany
Neuron 16:275-86. 1996..These findings indicate that proneural and E(spl) proteins exert antagonistic functions...
- Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in DrosophilaC M Chen
Emory University, Department of Biology, Atlanta, GA 30322, USA
Mech Dev 57:215-27. 1996..Synergistic interactions between pyd and Notch, Delta and extramacrochaetae mutations support this model. We also demonstrate that pyd is required for normal eye development...
- Control of neural precursor specification by proneural proteins in the CNS of DrosophilaC Parras
Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma, Madrid, Spain
EMBO J 15:6394-9. 1996....
- Two-step induction of chordotonal organ precursors in Drosophila embryogenesisM Okabe
Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
Development 124:1045-53. 1997..Three of these argos-expressing cells differentiate into the three remaining COPs and they prevent neighboring cells from becoming extra COPs...
- Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesisW Zhong
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 94143, USA
Development 124:1887-97. 1997....
- Nucleotide compositional constraints on genomes generate alanine-, glycine-, and proline-rich structures in transcription factorsY Nakachi
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
Mol Biol Evol 14:1042-9. 1997..Furthermore, reptile class III POU sequences revealed no evolutionary directionality increasing the GC contents from cold- to warm-blooded vertebrates...
- The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and DeltaD Doherty
Howard Hughes Medical Institute and the Department of Biochemistry, University of California, San Francisco 94143 0724, USA
Development 124:3881-93. 1997..These results are consistent with bib acting as a channel protein in proneural cluster cells that adopt the epidermal cell fate, and serving a necessary function in the response of these cells to the lateral inhibition signal...
- A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid systemP Alifragis
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, and Department of Biology, University of Crete, Heraklion, Greece
Proc Natl Acad Sci U S A 94:13099-104. 1997..We investigated the structural requirements for some of these interactions by site-specific and deletion mutagenesis...
- Asymmetric cell divisionY N Jan
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 94143 0725, USA
Nature 392:775-8. 1998....
- The function of hairy-related bHLH repressor proteins in cell fate decisionsA Fisher
Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York, USA
Bioessays 20:298-306. 1998..This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis...
- Asymmetry and cell fate in the Drosophila embryonic CNSS Fuerstenberg
Department of Cell and Structural Biology, University of Illinois, Urbana 61821, USA
Int J Dev Biol 42:379-83. 1998....
- Krüppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of DrosophilaM Hoch
Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, D 37077 Gottingen, Germany
EMBO J 17:5766-75. 1998....
- Snail-type zinc finger proteins prevent neurogenesis in Scutoid and transgenic animals of DrosophilaN Fuse
National Institute of Genetics, 1111 Yata, Mishima, Shizuoka ken 411 8540, Japan
Dev Genes Evol 209:573-80. 1999..Thus, our results suggest that the Scutoid phenotype is due to an ectopic snail expression under the control of no-oceli enhancer, antagonizing neurogenesis through its inhibitory interaction with bHLH proteins...
- Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher DipteraC Wülbeck
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
Development 127:1411-20. 2000..Some aspects of the transcriptional regulation have changed, however, and correlate in the notum with differences in the bristle pattern. The Ceratitis pannier gene was isolated and displays a conserved expression domain in the notum...
- The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous systemM L Huang
Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
Neuron 25:57-67. 2000..Loss of amos function eliminates MD neurons that remain in ASC;atonal mutants. Misexpression of amos generates ectopic MD and other types of neurons...
- neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosisE Pavlopoulos
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Crete, Greece
Dev Cell 1:807-16. 2001..The potent modulatory effect of Neur on Dl activity makes Neur a candidate for establishing signaling asymmetries within cellular equivalence groups...
- Precocious expression of the Glide/Gcm glial-promoting factor in Drosophila induces neurogenesisVeronique Van de Bor
Institut de Génétique et Biologie Moléculaire et Cellulaire IGBMC CNRS ULP INSERM BP 163 67404 Illkirch, C U de Strasbourg, France
Genetics 160:1095-106. 2002..These findings also emphasize the requirement for both spatial and temporal glide/gcm regulation to achieve proper cell specification within the nervous system...
- Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosisDaniela Berdnik
Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030, Vienna, Austria
Curr Biol 12:640-7. 2002..What triggers the asymmetric localization of Numb at the onset of mitosis is unclear...
- Variability on the dot chromosome in the Drosophila simulans cladeMohamed A F Noor
Department of Biological Sciences, Life Sciences Bldg, Louisiana State University, Baton Rouge, LA 70803, USA
Genetica 118:51-8. 2003..Overall, none of the data analyzed were consistent with recent introgression exclusively between D. simulans and D. mauritiana...
- An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in DrosophilaAnton Golovnin
Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Moscow 117334, Russia
Development 130:3249-58. 2003..Genetic analysis shows that at least two proteins, Suppressor of Hairy wing and Modifier of MDG4, required for the activity of this insulator, are involved in the transcriptional regulation of Achaete-scute...
- Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteinsHongyan Wang
Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604
Nat Cell Biol 7:1091-8. 2005..In addition, Gbetagamma acts to restrict Galphai (and GoLoco proteins) to the apical cortex, where Galphai (and Pins) can mediate asymmetric spindle geometry...
- The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybeeRebekka Schlatter
Universitat Hohenheim, Institut fur Genetik, Garbenstr 30, 70599 Stuttgart, Germany
BMC Evol Biol 5:67. 2005..The question arose how these complexes evolved with regard to gene number in the evolution of insects concentrating on Diptera and the Hymenoptera Apis mellifera...
- Mitotic activation of the kinase Aurora-A requires its binding partner BoraAndrea Hutterer
Institute of Molecular Biotechnology IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
Dev Cell 11:147-57. 2006..We propose a model in which activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate Aurora-A...
- Redundant mechanisms mediate bristle patterning on the Drosophila thoraxKazuya Usui
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Proc Natl Acad Sci U S A 105:20112-7. 2008..However, ubiquitous expression of sc or asense (ase) achieved with a heterologous promoter, in the absence of endogenous ac-sc expression, and the activity of the cis-..
- dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repressionNatascha Kunert
Institut fur Molekularbiologie und Tumorforschung, Universitat Marburg, Marburg, Germany
EMBO J 28:533-44. 2009..However, despite lacking a histone deacetylase subunit, only dMec contributes to the repression of proneural genes. These results reveal an unexpected complexity in the composition and function of Mi-2 complexes...
- Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursorsJ E Johnson
Division of Biology 216 76, California Institute of Technology, Pasadena 91125
Nature 346:858-61. 1990..At least one of these genes is transiently expressed in the embryonic rat nervous system, is not detected in non-neuronal tissues or cell lines, and is induced by nerve growth factor in PC12 cells...
- Proneural and neurogenic genes control specification and Morphogenesis of stomatogastric nerve cell precursors in DrosophilaV Hartenstein
Department of Biology, University of California, Los Angeles 90095 1606, USA
Dev Biol 173:213-27. 1996....
- Invertebrate versus vertebrate neurogenesis: variations on the same theme?A Salzberg
Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas
Dev Genet 18:1-10. 1996
- Regulatory interactions during early neurogenesis in DrosophilaB Hassan
Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus 43210, USA
Dev Genet 18:18-27. 1996..While lineage identity genes allow the various lineages to acquire specific identities, neuronal precursor genes presumably regulate functional and developmental characteristics common to all neuronal precursor cells...