ase

Summary

Gene Symbol: ase
Description: asense
Alias: AS-C T8, AS-C T8ase, AS-T8, ASC, Ase, CG3258, Dmel\CG3258, EG:165H7.2, T1A, T1a, as-T8, ascT8, bHLHc28, sc/T8, CG3258 gene product from transcript CG3258-RA, CG3258-PA, ase-PA
Species: fruit fly

Top Publications

  1. ncbi asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation
    M Brand
    Howard Huges Medical Institute, University of California, San Francisco, CA 94143 0724, USA
    Development 119:1-17. 1993
  2. ncbi Patterning of the Drosophila nervous system: the achaete-scute gene complex
    S Campuzano
    Centro de Biologia Molecular, CSIC, Madrid, Spain
    Trends Genet 8:202-8. 1992
  3. ncbi prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 67:941-53. 1991
  4. pmc The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes
    M C Alonso
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 7:2585-91. 1988
  5. pmc Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe development
    F Gonzalez
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Canto Blanco, Spain
    EMBO J 8:3553-62. 1989
  6. ncbi daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
    Development 120:935-45. 1994
  7. ncbi Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs
    J L Gomez-Skarmeta
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Genes Dev 9:1869-82. 1995
  8. ncbi The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes
    U Hinz
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
    Cell 76:77-87. 1994
  9. ncbi Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
    P Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, Strasbourg, France
    Development 122:161-71. 1996
  10. ncbi inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein
    R Kraut
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Cologne, Germany
    Dev Biol 174:65-81. 1996

Scientific Experts

Detail Information

Publications111 found, 100 shown here

  1. ncbi asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation
    M Brand
    Howard Huges Medical Institute, University of California, San Francisco, CA 94143 0724, USA
    Development 119:1-17. 1993
    ..Our studies therefore serve as a cautionary note for the inference of normal gene function based on the gain-of-function phenotype after ectopic expression...
  2. ncbi Patterning of the Drosophila nervous system: the achaete-scute gene complex
    S Campuzano
    Centro de Biologia Molecular, CSIC, Madrid, Spain
    Trends Genet 8:202-8. 1992
    ..Neuroblasts or sensory organ mother cells are born within these clusters. Thus, the patterns of expression of the AS-C genes help to define the topology of the nervous system...
  3. ncbi prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Cell 67:941-53. 1991
    ..prospero encodes a large nuclear protein with multiple homopolymeric amino acid stretches and is expressed in neuronal precursors early during their formation. It is probably generally required for proper neuronal differentiation...
  4. pmc The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes
    M C Alonso
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 7:2585-91. 1988
    ..We discuss the possible biochemical function of the AS-C in neurogenesis in the light of the homologies of the four genes with the mammalian myc family...
  5. pmc Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe development
    F Gonzalez
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Canto Blanco, Spain
    EMBO J 8:3553-62. 1989
    ..It comprises 22 kb of DNA and contains two transcription units, only one of which, named asense (ase), seems involved in neurogenesis...
  6. ncbi daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
    Development 120:935-45. 1994
    ..da is not required for the initial appearance of nascent neuronal precursors but is required for these cells to express multiple neuronal precursor genes and to produce the normal number of neurons...
  7. ncbi Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs
    J L Gomez-Skarmeta
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Genes Dev 9:1869-82. 1995
    ..Our data indicate that coexpression is accomplished by activation of both ac and sc by the same set of position-specific enhancers...
  8. ncbi The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes
    U Hinz
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
    Cell 76:77-87. 1994
    ..Finally, the bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition...
  9. ncbi Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila
    P Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, Strasbourg, France
    Development 122:161-71. 1996
    ..Thus there is a regulatory loop between Notch and Delta that is under the transcriptional control of the E(spl)-C and AS-C genes...
  10. ncbi inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein
    R Kraut
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Cologne, Germany
    Dev Biol 174:65-81. 1996
    ..The inscuteable mutant phenotype, together with these other observations, suggests a possible role for the protein in cytoskeleton organization...
  11. ncbi Control of daughter cell fates during asymmetric division: interaction of Numb and Notch
    M Guo
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0724, USA
    Neuron 17:27-41. 1996
    ..This leads to Ttk expression in the daughter cell that does not inherit Numb. Thus, the inherited determinant Numb bestows a bias in the machinery for cell-cell communication to allow the specification of distinct daughter cell fates...
  12. pmc Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling
    J Culi
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Genes Dev 12:2036-47. 1998
    ..These data suggest a mechanism for SMC committment...
  13. ncbi The specificity of proneural genes in determining Drosophila sense organ identity
    A P Jarman
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JR, UK
    Mech Dev 76:117-25. 1998
    ....
  14. ncbi Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors
    P zur Lage
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, UK
    Development 126:3149-57. 1999
    ..SOP recruitment is reiterative because the inductive signal comes from previously recruited SOPs...
  15. ncbi Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts
    M Schober
    Research Institute of Molecular Pathology, Vienna, Austria
    Nature 402:548-51. 1999
    ..Our results suggest that direct binding to Bazooka mediates the asymmetric localization of Inscuteable and connects the asymmetric division of neuroblasts to the axis of epithelial apical-basal polarity...
  16. ncbi The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes
    K Wallace
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
    Genesis 26:77-85. 2000
    ..Thus, regulation of mitotic activity during optic lobe development may, at least in part, involve deadpan and asense mediated regulation of the cyclin dependent kinase inhibitor gene dacapo. genesis 26:77-85, 2000...
  17. ncbi cato encodes a basic helix-loop-helix transcription factor implicated in the correct differentiation of Drosophila sense organs
    S E Goulding
    Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JR, United Kingdom
    Dev Biol 221:120-31. 2000
    ..Moreover, in prospero mutants, in which axon and dendrite outgrowth is defective, cato is strongly derepressed in the developing CNS...
  18. ncbi Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
    R Nolo
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 102:349-62. 2000
    ..Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs...
  19. ncbi Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system
    M Schaefer
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Cell 107:183-94. 2001
    ..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types...
  20. ncbi Gene duplication at the achaete-scute complex and morphological complexity of the peripheral nervous system in Diptera
    Nick Skaer
    Dept of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Trends Genet 18:399-405. 2002
    ..This probably coincided in time with gene duplication events, raising the possibility that an increase in gene copy number might have provided the flexibility necessary for more complex transcriptional regulation...
  21. ncbi Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
    Roger Albertson
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, OR 97403, USA
    Nat Cell Biol 5:166-70. 2003
    ..We conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts...
  22. ncbi Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions
    Naoyuki Fuse
    Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, Chuou ku, Kobe 650 0047, Japan
    Curr Biol 13:947-54. 2003
    ..Furthermore, the multiple equal cleavages of G beta mutant neuroblasts accompany neural defects; this finding suggests indispensable roles of eccentric division in assuring the stem cell properties of neuroblasts...
  23. ncbi Segment polarity and DV patterning gene expression reveals segmental organization of the Drosophila brain
    Rolf Urbach
    Institut fur Genetik, Universitat Mainz, D 55099 Mainz, Germany
    Development 130:3607-20. 2003
    ..The labral neuromere is confined to the posterior segmental compartment. Finally, similarities in the expression of DV patterning genes between the Drosophila and vertebrate brains are discussed...
  24. pmc phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development
    Haiwei Pi
    Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Proc Natl Acad Sci U S A 101:8378-83. 2004
    ..Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation...
  25. ncbi An ancient transcriptional regulatory linkage
    Mark Rebeiz
    Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093 0349, USA
    Dev Biol 281:299-308. 2005
    ..We suggest that the systematic identification of such ancient and conserved connections will be a powerful means of uncovering the primordial functions of transcription factors and signaling systems...
  26. pmc Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe
    Boris Egger
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Neural Dev 2:1. 2007
    ..In some tissues cell fate appears to dictate the type of cell division, whereas in other tissues it is thought that stochastic variation in spindle position dictates subsequent sibling cell fate...
  27. pmc NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila
    Savita Ayyar
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 2:e1178. 2007
    ..We propose that this buffering of gene expression levels serves to keep the neuro-epithelium constantly poised for neurogenesis...
  28. doi Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT
    Tetsuo Yasugi
    Laboratory of Pattern Formation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:1471-80. 2008
    ....
  29. pmc The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 14:535-46. 2008
    ..Our data describe a transit-amplifying lineage in the Drosophila nervous system and suggest that different vulnerabilities in intermediate cell types can affect the outcome of tumor suppressor loss in stem cell lineages...
  30. doi dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila
    Mo Weng
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
    Dev Cell 18:126-35. 2010
    ..We conclude that Erm dependence functionally distinguishes intermediate neural progenitors from neuroblasts in the Drosophila larval brain, balancing neurogenesis with stem cell maintenance...
  31. doi Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal
    Kai Chen Chang
    Temasek Life Sciences Laboratory, 1 Research Link, Singapore 117604
    Dev Cell 19:778-85. 2010
    ..Thus, reciprocal repression between Zif and aPKC act as a critical regulatory mechanism for establishing cell polarity and controlling neuroblast self-renewal...
  32. doi The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila
    Beatriz P San-Juán
    Centro de Biología Molecular Severo Ochoa Consejo Superior Investigaciones Científicas, Universidad Autonoma de Madrid, Nicolas Cabrera 1, 28049, Madrid, Spain
    Dev Biol 352:70-82. 2011
    ..We show that in addition to dpn, Notch signaling must be regulating other genes during this process that act redundantly with dpn...
  33. pmc Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila
    Yingshi Ouyang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 138:2185-96. 2011
    ..Reduction of Dronc activity facilitates ENF induced by phospho-Numb. Our findings uncover a molecular mechanism that regulates Numb activity and suggest a novel role for Dronc caspase in regulating neural stem cell homeostasis...
  34. doi An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts
    Cheng Wang
    Neuroscience and Behavioral Disorder Program, Duke National University of Singapore Graduate Medical School Singapore, Singapore, Singapore
    Dev Cell 21:520-33. 2011
    ..Our findings reveal that the centrosomal proteins Ana2 and Ctp regulate Mud function to orient the mitotic spindle during NB asymmetric division...
  35. pmc Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis
    Travis D Carney
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
    Dev Biol 361:137-46. 2012
    ..These genes are excellent candidates for regulating neural progenitor self-renewal in Drosophila and mammals...
  36. pmc Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains
    Sijun Zhu
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:20615-20. 2011
    ..are produced from type II neuroblasts (NBs, Drosophila neural stem cells), which lack the proneural protein Asense (Ase) but not from Ase-expressing type I NBs...
  37. pmc klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division
    Qi Xiao
    Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Development 139:2670-80. 2012
    ..These results led us to propose that multiple mechanisms converge to exert precise control of klu and distinguish a progenitor cell from its sibling stem cell during asymmetric neuroblast division...
  38. pmc The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine
    Xiankun Zeng
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    Development 140:3532-40. 2013
    ..Our data uncover a unique mechanism whereby the commitment of stem cells to discrete lineages is coordinately regulated by chromatin-remodeling factors. ..
  39. pmc midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in Drosophila
    Travis D Carney
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA
    Development 140:4155-64. 2013
    ..We conclude that Mdlc plays an essential role in maintaining neuronal differentiation, raising the possibility that RNF113A regulates neuronal differentiation in the human CNS. ..
  40. pmc asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation gene
    M Dominguez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Spain
    EMBO J 12:2049-60. 1993
    The asense (ase) gene of the achaete-scute complex (AS-C) is expressed in the precursors of all adult sensory organs (SOs), the sensory mother cells (SMCs) and in their immediate progeny...
  41. ncbi The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors
    A P Jarman
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143 0724, USA
    Development 119:19-29. 1993
    ..asense differs from the other AS-C members in its expression pattern, regulation, mutant phenotype and some DNA-binding properities...
  42. ncbi Early neurogenesis of the Drosophila brain
    A Younossi-Hartenstein
    Department of Cellular Molecular and Developmental Biology, University of California Los Angeles 90024, USA
    J Comp Neurol 370:313-29. 1996
    ..With respect to their position and the expression of the markers asense (ase) and seven-up (svp), 23 small groups of one to five neuroblasts each were identified...
  43. ncbi Adherens junctions inhibit asymmetric division in the Drosophila epithelium
    B Lu
    Howard Hughes Medical Institute and Department of Physiology, University of California at San Francisco, 94143 0725, USA
    Nature 409:522-5. 2001
    ..Our results indicate that neuroepithelial cells have all the necessary components to execute asymmetric division, but that this pathway is normally overridden by the planar polarity cue provided by adherens junctions...
  44. ncbi The development and evolution of bristle patterns in Diptera
    P Simpson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, C U de Strasbourg, France u strasbg fr
    Development 126:1349-64. 1999
    ....
  45. ncbi Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of Drosophila
    M Hoch
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, FRG
    Development 120:3439-50. 1994
    ..We demonstrate that both stages in the differentiation of this cell are established by the same sequence of genetic interactions, which have not previously been shown to occur outside the neurogenic ectoderm...
  46. ncbi Lethal of scute requires overexpression of daughterless to elicit ectopic neuronal development during embryogenesis in Drosophila
    B Giebel
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Mech Dev 63:75-87. 1997
    ..Under the present conditions, lateral inhibition is thus dominant over the activity of proneural genes...
  47. ncbi neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development
    E C Lai
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, 539 Life Sciences Addition, Berkeley, California 94720, USA
    Dev Biol 231:217-33. 2001
    ..Collectively, these data indicate a key role for neu in the reception of the lateral inhibitory signal during peripheral neurogenesis...
  48. ncbi Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system
    Gregory Emery
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 122:763-73. 2005
    ..Our results suggest that cells can regulate signaling pathways and influence their developmental fate by inhibiting the formation of individual endocytic compartments...
  49. ncbi The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila
    Ciara M Gallagher
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 11:641-53. 2006
    ..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs...
  50. pmc Drosophila Hey is a target of Notch in asymmetric divisions during embryonic and larval neurogenesis
    Maria Monastirioti
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, 100 N Plastira St, 70013 Heraklion, Crete, Greece
    Development 137:191-201. 2010
    ..The availability of Hey as a Notch readout has allowed us to study Notch signalling during the genesis of secondary neurons in the larval central nervous system...
  51. pmc The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis
    Petra I zur Lage
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 10:34. 2010
    ..cousin of atonal (cato) encodes one such factor that is expressed widely in the developing sensory nervous system of Drosophila. However, nothing definitive was known of its function owing to the lack of specific mutations...
  52. pmc An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the Cambrian
    Savita Ayyar
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    BMC Biol 8:127. 2010
    ..First identified in Drosophila, the SOPE contains discrete binding sites for four regulatory factors. The SOPE of the Drosophila asense gene is situated in the 5' UTR...
  53. pmc Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex
    Omer Ali Bayraktar
    Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Neural Dev 5:26. 2010
    ..In addition, we use 9D11 lineage tracing to show that type II lineages generate both small-field and large-field neurons within the adult central complex, a brain region required for locomotion, flight, and visual pattern memory...
  54. pmc Essential roles of Da transactivation domains in neurogenesis and in E(spl)-mediated repression
    Ioanna Zarifi
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, and Department of Biology, University of Crete, Heraklion, Crete, Greece
    Mol Cell Biol 32:4534-48. 2012
    ..We present a mechanistic model on the interplay of these bHLH factors in the context of neural fate assignment...
  55. pmc COPS: detecting co-occurrence and spatial arrangement of transcription factor binding motifs in genome-wide datasets
    Nati Ha
    Centre for Organismal Studies COS Heidelberg, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e52055. 2012
    ..In sum, COPS is a fast, efficient and user-friendly tool mining statistically and biologically significant TFBS co-occurrences and therefore allows the identification of TFs that combinatorially regulate gene expression...
  56. pmc Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in Drosophila
    Alla Amcheslavsky
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Rep 9:32-9. 2014
    ..These results establish that enteroendocrine cells serve as an important link between diet and visceral muscle expression of an insulin-like growth factor to stimulate intestinal stem cell proliferation and tissue growth. ..
  57. pmc Keeping intestinal stem cell differentiation on the Tramtrack
    Chenhui Wang
    a National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing, China
    Fly (Austin) 9:110-4. 2015
    ..In this Extra View, we also provide a brief discussion of recent progress and remaining questions concerning EE cell specification in adult Drosophila midgut. ..
  58. ncbi The bHLH genes in neural development
    C Dambly-Chaudiere
    Laboratoire de Neurogénétique, Unité 432 INSERM, Universite Montpellier II, France
    Int J Dev Biol 42:269-73. 1998
    ..In this review, we discuss the significance of this phenomenon in the case of the basic Helix-Loop-Helix (bHLH) proteins that are involved at different steps of the development of the peripheral nervous system (PNS) of Drosophila...
  59. pmc The origins of the Drosophila leg revealed by the cis-regulatory architecture of the Distalless gene
    Daniel J Mckay
    Department of Biochemistry and Molecular Biophysics, Integrated Program in Cellular, Molecular, Structural and Genetic Studies, Columbia University, 701 W 168th Street, HHSC 1104, New York, NY 10032, USA
    Development 136:61-71. 2009
    ..Together, these findings provide a complete and high-resolution fate map of the Drosophila appendage primordia, linking the primary domains to specific cis-regulatory elements in Dll...
  60. pmc Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons
    Suewei Lin
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 4:e8392. 2009
    ..In sum, unf governs axonal morphogenesis of multiple MB neuron types, possibly through regulating neuronal subtype identity...
  61. pmc Differential regulation of transcription through distinct Suppressor of Hairless DNA binding site architectures during Notch signaling in proneural clusters
    John W Cave
    Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA
    Mol Cell Biol 31:22-9. 2011
    ....
  62. pmc Ancestral and conserved cis-regulatory architectures in developmental control genes
    Mark Rebeiz
    Division of Biological Sciences CDB, University of California San Diego, La Jolla, CA 92093, USA
    Dev Biol 362:282-94. 2012
    ..We propose that these stable motif architectures have been conserved intact from a deep ancestor, in part because they mediate a special mode of regulation that cannot be supplied by the other, unstable motif instances...
  63. pmc Cortical aPKC kinase activity distinguishes neural stem cells from progenitor cells by ensuring asymmetric segregation of Numb
    Jill M Haenfler
    Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 365:219-28. 2012
    ....
  64. ncbi The generation of cell diversity during early neurogenesis in Drosophila
    C V Cabrera
    Marie Curie Research Institute, Oxted, UK
    Development 115:893-901. 1992
  65. ncbi The Drosophila segmentation gene runt acts as a position-specific numerator element necessary for the uniform expression of the sex-determining gene Sex-lethal
    J B Duffy
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Genes Dev 5:2176-87. 1991
    ..runt is distinguished from previously identified regulators of Sxl by its nonuniform role and by the absence of an identifiable helix-loop-helix (HLH) motif, indicating that the activation of Sxl is not controlled solely by HLH proteins...
  66. ncbi Role of helix-loop-helix proteins in Drosophila neurogenesis
    H Vaessin
    Howard Hughes Medical Institute, University of California, San Francisco 94143
    Cold Spring Harb Symp Quant Biol 55:239-45. 1990
  67. ncbi Molecular genetics of the achaete-scute gene complex of D. melanogaster
    S Campuzano
    Cell 40:327-38. 1985
    ..Two additional polyadenylated RNAs are transcribed from the achaete (1.1 kb) and yellow (1.9 kb) loci...
  68. ncbi Proneural genes influence gliogenesis in Drosophila
    A Giangrande
    Institut de Genetique et de Biologie Molecularie et Cellulaire, CNRS UPR6520 INSERM U 184 ULP, Illkirch, CU de Strasbourg, France
    Development 121:429-38. 1995
    ..These observations lead to the hypothesis that gliogenesis is induced by the presence of sensory organ cells, either the precursor or its progeny...
  69. ncbi Embryonic development of the stomatogastric nervous system in Drosophila
    V Hartenstein
    Department of Biology, University of California at Los Angeles 90024
    J Comp Neurol 350:367-81. 1994
    ..Both recurrent nerve and frontal connectives are pioneered by small subpopulations of early differentiating stomatogastric neurons that most likely derive from among the dSNSPs and iSNSPs...
  70. ncbi Neuronal cell fate specification in Drosophila
    Y N Jan
    Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco 94143 0724
    Curr Opin Neurobiol 4:8-13. 1994
    ..Selective expression of certain neuronal-type selector genes further specifies the type of neuron(s) that a neural precursor will produce...
  71. pmc Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development
    D F Lyman
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA dlyman biology emory edu
    Genetics 141:1491-505. 1995
    ..The results suggest that H insulates SOP cells from inhibition and indicate that H activity is suppressed by Notch signaling...
  72. pmc The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions
    D Bettler
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Genetics 143:859-75. 1996
    ..Immunohistochemical detection of Mam on polytene chromosomes revealed binding at > 100 sites. Chromosome colocalization studies with RNA polymerase and the groucho corepressor protein implicate Mam in transcriptional regulation...
  73. ncbi Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila
    K Nakao
    Institut für Entwicklungsbiologie Universität zu Köln, Germany
    Neuron 16:275-86. 1996
    ..These findings indicate that proneural and E(spl) proteins exert antagonistic functions...
  74. ncbi Polychaetoid is required to restrict segregation of sensory organ precursors from proneural clusters in Drosophila
    C M Chen
    Emory University, Department of Biology, Atlanta, GA 30322, USA
    Mech Dev 57:215-27. 1996
    ..Synergistic interactions between pyd and Notch, Delta and extramacrochaetae mutations support this model. We also demonstrate that pyd is required for normal eye development...
  75. pmc Control of neural precursor specification by proneural proteins in the CNS of Drosophila
    C Parras
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma, Madrid, Spain
    EMBO J 15:6394-9. 1996
    ....
  76. ncbi Two-step induction of chordotonal organ precursors in Drosophila embryogenesis
    M Okabe
    Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Development 124:1045-53. 1997
    ..Three of these argos-expressing cells differentiate into the three remaining COPs and they prevent neighboring cells from becoming extra COPs...
  77. ncbi Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis
    W Zhong
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 94143, USA
    Development 124:1887-97. 1997
    ....
  78. ncbi Nucleotide compositional constraints on genomes generate alanine-, glycine-, and proline-rich structures in transcription factors
    Y Nakachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Mol Biol Evol 14:1042-9. 1997
    ..Furthermore, reptile class III POU sequences revealed no evolutionary directionality increasing the GC contents from cold- to warm-blooded vertebrates...
  79. ncbi The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta
    D Doherty
    Howard Hughes Medical Institute and the Department of Biochemistry, University of California, San Francisco 94143 0724, USA
    Development 124:3881-93. 1997
    ..These results are consistent with bib acting as a channel protein in proneural cluster cells that adopt the epidermal cell fate, and serving a necessary function in the response of these cells to the lateral inhibition signal...
  80. pmc A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system
    P Alifragis
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, and Department of Biology, University of Crete, Heraklion, Greece
    Proc Natl Acad Sci U S A 94:13099-104. 1997
    ..We investigated the structural requirements for some of these interactions by site-specific and deletion mutagenesis...
  81. ncbi Asymmetric cell division
    Y N Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 94143 0725, USA
    Nature 392:775-8. 1998
    ....
  82. ncbi The function of hairy-related bHLH repressor proteins in cell fate decisions
    A Fisher
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York, USA
    Bioessays 20:298-306. 1998
    ..This general function in cell fate specification has been conserved from Drosophila to vertebrates and has implications for human disease pathogenesis...
  83. ncbi Asymmetry and cell fate in the Drosophila embryonic CNS
    S Fuerstenberg
    Department of Cell and Structural Biology, University of Illinois, Urbana 61821, USA
    Int J Dev Biol 42:379-83. 1998
    ....
  84. pmc Krüppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of Drosophila
    M Hoch
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, D 37077 Gottingen, Germany
    EMBO J 17:5766-75. 1998
    ....
  85. ncbi Snail-type zinc finger proteins prevent neurogenesis in Scutoid and transgenic animals of Drosophila
    N Fuse
    National Institute of Genetics, 1111 Yata, Mishima, Shizuoka ken 411 8540, Japan
    Dev Genes Evol 209:573-80. 1999
    ..Thus, our results suggest that the Scutoid phenotype is due to an ectopic snail expression under the control of no-oceli enhancer, antagonizing neurogenesis through its inhibitory interaction with bHLH proteins...
  86. ncbi Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher Diptera
    C Wülbeck
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
    Development 127:1411-20. 2000
    ..Some aspects of the transcriptional regulation have changed, however, and correlate in the notum with differences in the bristle pattern. The Ceratitis pannier gene was isolated and displays a conserved expression domain in the notum...
  87. ncbi The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system
    M L Huang
    Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
    Neuron 25:57-67. 2000
    ..Loss of amos function eliminates MD neurons that remain in ASC;atonal mutants. Misexpression of amos generates ectopic MD and other types of neurons...
  88. ncbi neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis
    E Pavlopoulos
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Crete, Greece
    Dev Cell 1:807-16. 2001
    ..The potent modulatory effect of Neur on Dl activity makes Neur a candidate for establishing signaling asymmetries within cellular equivalence groups...
  89. pmc Precocious expression of the Glide/Gcm glial-promoting factor in Drosophila induces neurogenesis
    Veronique Van de Bor
    Institut de Génétique et Biologie Moléculaire et Cellulaire IGBMC CNRS ULP INSERM BP 163 67404 Illkirch, C U de Strasbourg, France
    Genetics 160:1095-106. 2002
    ..These findings also emphasize the requirement for both spatial and temporal glide/gcm regulation to achieve proper cell specification within the nervous system...
  90. ncbi Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis
    Daniela Berdnik
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 12:640-7. 2002
    ..What triggers the asymmetric localization of Numb at the onset of mitosis is unclear...
  91. ncbi Variability on the dot chromosome in the Drosophila simulans clade
    Mohamed A F Noor
    Department of Biological Sciences, Life Sciences Bldg, Louisiana State University, Baton Rouge, LA 70803, USA
    Genetica 118:51-8. 2003
    ..Overall, none of the data analyzed were consistent with recent introgression exclusively between D. simulans and D. mauritiana...
  92. ncbi An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in Drosophila
    Anton Golovnin
    Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Moscow 117334, Russia
    Development 130:3249-58. 2003
    ..Genetic analysis shows that at least two proteins, Suppressor of Hairy wing and Modifier of MDG4, required for the activity of this insulator, are involved in the transcriptional regulation of Achaete-scute...
  93. ncbi Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins
    Hongyan Wang
    Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604
    Nat Cell Biol 7:1091-8. 2005
    ..In addition, Gbetagamma acts to restrict Galphai (and GoLoco proteins) to the apical cortex, where Galphai (and Pins) can mediate asymmetric spindle geometry...
  94. pmc The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee
    Rebekka Schlatter
    Universitat Hohenheim, Institut fur Genetik, Garbenstr 30, 70599 Stuttgart, Germany
    BMC Evol Biol 5:67. 2005
    ..The question arose how these complexes evolved with regard to gene number in the evolution of insects concentrating on Diptera and the Hymenoptera Apis mellifera...
  95. ncbi Mitotic activation of the kinase Aurora-A requires its binding partner Bora
    Andrea Hutterer
    Institute of Molecular Biotechnology IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Dev Cell 11:147-57. 2006
    ..We propose a model in which activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate Aurora-A...
  96. pmc Redundant mechanisms mediate bristle patterning on the Drosophila thorax
    Kazuya Usui
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Proc Natl Acad Sci U S A 105:20112-7. 2008
    ..However, ubiquitous expression of sc or asense (ase) achieved with a heterologous promoter, in the absence of endogenous ac-sc expression, and the activity of the cis-..
  97. pmc dMec: a novel Mi-2 chromatin remodelling complex involved in transcriptional repression
    Natascha Kunert
    Institut fur Molekularbiologie und Tumorforschung, Universitat Marburg, Marburg, Germany
    EMBO J 28:533-44. 2009
    ..However, despite lacking a histone deacetylase subunit, only dMec contributes to the repression of proneural genes. These results reveal an unexpected complexity in the composition and function of Mi-2 complexes...
  98. ncbi Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors
    J E Johnson
    Division of Biology 216 76, California Institute of Technology, Pasadena 91125
    Nature 346:858-61. 1990
    ..At least one of these genes is transiently expressed in the embryonic rat nervous system, is not detected in non-neuronal tissues or cell lines, and is induced by nerve growth factor in PC12 cells...
  99. ncbi Proneural and neurogenic genes control specification and Morphogenesis of stomatogastric nerve cell precursors in Drosophila
    V Hartenstein
    Department of Biology, University of California, Los Angeles 90095 1606, USA
    Dev Biol 173:213-27. 1996
    ....
  100. ncbi Invertebrate versus vertebrate neurogenesis: variations on the same theme?
    A Salzberg
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas
    Dev Genet 18:1-10. 1996
  101. ncbi Regulatory interactions during early neurogenesis in Drosophila
    B Hassan
    Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus 43210, USA
    Dev Genet 18:18-27. 1996
    ..While lineage identity genes allow the various lineages to acquire specific identities, neuronal precursor genes presumably regulate functional and developmental characteristics common to all neuronal precursor cells...