arm

Summary

Gene Symbol: arm
Description: armadillo
Alias: ARM, Arm, CG11579, Dm Arm, Dmel\CG11579, EG:86E4.6, beta-Cat, beta-cat, beta-cat-arm, beta-catenin, beta-catenin/Arm, betacat, bgr;-Cat, l(1)2Bv, l(1)G0192, l(1)G0234, l(1)G0410, l(1)arm, t12687 ALR Dm, CG11579 gene product from transcript CG11579-RD, Armadillo(Arm)/beta-catenin, Armadillo/beta-catenin, Armadillo/bgr;-catenin, Beta-catenin/Arm, CG11579-PA, CG11579-PB, CG11579-PC, CG11579-PD, CG11579-PE, CG11579-PF, alpha-Catenin, arm-PA, arm-PB, arm-PC, arm-PD, arm-PE, arm-PF, b-catenin, beta-Catenin, beta-catenin/Armadillo, betacatenin, bgr;-catenin, catenin
Species: fruit fly

Top Publications

  1. ncbi Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    D Bilder
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:676-80. 2000
  2. pmc DE-Cadherin is required for intercellular motility during Drosophila oogenesis
    P Niewiadomska
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 144:533-47. 1999
  3. ncbi From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion
    R Kemler
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Trends Genet 9:317-21. 1993
  4. pmc The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis
    Rebecca Bastock
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 134:3055-64. 2007
  5. doi The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Dev Cell 16:411-20. 2009
  6. ncbi Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer
    J Bai
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 103:1047-58. 2000
  7. ncbi Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation
    H Oda
    Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Kyoto, Chudoji Minami machi, Shimogyo ku, 600 8813, Japan
    Dev Biol 203:435-50. 1998
  8. ncbi Multicellular rosette formation links planar cell polarity to tissue morphogenesis
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Cell 11:459-70. 2006
  9. ncbi The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Cell Sci 120:3099-110. 2007
  10. pmc The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties
    M Peifer
    Department of Biology, University of North Carolina, Chapel Hill 27599
    J Cell Biol 118:681-91. 1992

Research Grants

  1. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
  2. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
  3. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
  4. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
  5. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
  6. Novel Cilia Trafficking Mechanisms
    BENJAMIN L MARGOLIS; Fiscal Year: 2010
  7. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
  8. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
  9. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
  10. Tight Junction Proteins and Epithelial Polarity
    Benjamin Margolis; Fiscal Year: 2009

Detail Information

Publications207 found, 100 shown here

  1. ncbi Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    D Bilder
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 403:676-80. 2000
    ..Our results show that the lateral domain of epithelia, particularly the septate junction, functions in restricting apical membrane identity and correctly placing adherens junctions...
  2. pmc DE-Cadherin is required for intercellular motility during Drosophila oogenesis
    P Niewiadomska
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 144:533-47. 1999
    ..Finally, we show that the upregulation of DE-cadherin expression in border cells depends on the activity of the Drosophila C/EBP transcription factor that is essential for border cell migration...
  3. ncbi From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion
    R Kemler
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Trends Genet 9:317-21. 1993
    Classical cadherins are complexed via their cytoplasmic domains with alpha-, beta- and gamma-catenin. This complex formation links cadherins to the actin filament network and to other transmembrane and cytoplasmic proteins...
  4. pmc The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis
    Rebecca Bastock
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 134:3055-64. 2007
    ..We conclude that, during collective cell migration, the planar polarity pathway can mediate communication between motile and non-motile cells, which enhances the efficiency of migration via the modulation of actin dynamics...
  5. doi The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie
    Caroline Badouel
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Dev Cell 16:411-20. 2009
    ..These data lead to a new model whereby Expanded functions downstream of Warts, in concert with 14-3-3 proteins to sequester Yorkie in the cytoplasm, inhibiting growth activity of the Hippo pathway...
  6. ncbi Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer
    J Bai
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cell 103:1047-58. 2000
    ..Mutant cells exhibited abnormal accumulation of E-cadherin, beta-catenin, and focal adhesion kinase...
  7. ncbi Dynamic behavior of the cadherin-based cell-cell adhesion system during Drosophila gastrulation
    H Oda
    Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Kyoto, Chudoji Minami machi, Shimogyo ku, 600 8813, Japan
    Dev Biol 203:435-50. 1998
    ..immunocytochemical analysis of the localizations of DE-cadherin and its associated proteins Armadillo (beta-catenin) and Dalpha-catenin revealed dynamic changes in their distributions which were accompanied by changes in cell ..
  8. ncbi Multicellular rosette formation links planar cell polarity to tissue morphogenesis
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Cell 11:459-70. 2006
    ..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis...
  9. ncbi The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Cell Sci 120:3099-110. 2007
    ..These results suggest that epithelial polarity in the Drosophila embryo is actively maintained by exocyst-dependent apical localization of the Crumbs transmembrane protein...
  10. pmc The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties
    M Peifer
    Department of Biology, University of North Carolina, Chapel Hill 27599
    J Cell Biol 118:681-91. 1992
    ..gene armadillo, the human desmosomal protein plakoglobin, and the Xenopus E-cadherin-associated protein beta-catenin, share amino acid sequence similarity...
  11. ncbi Invasive cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade
    Jose Carlos Pastor-Pareja
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Cantoblanco, 28049 Madrid, Spain
    Dev Cell 7:387-99. 2004
    ..When eversion is completed, PS cells localize to the leading front, heading disc expansion. We found that the JNK pathway is necessary for PS/larval cells apposition, the PEMT, and the motile activity of leading front cells...
  12. ncbi Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila
    Sang Chul Nam
    Department of Molecular and Cellular Biology, Baylor College of Medicine, TX 77030, USA
    Development 130:4363-72. 2003
    ..These results suggest that the interaction of Crb and Par-6 complexes is required for the organization and maintenance of apical membranes and AJs of photoreceptors...
  13. ncbi Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
    D Bilder
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 289:113-6. 2000
    ..scrib, dlg, and lgl show strong genetic interactions. Our data indicate that the three tumor suppressors act together in a common pathway to regulate cell polarity and growth control...
  14. ncbi Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells
    M Starz-Gaiano
    Howard Hughes Medical Institute, Developmental Genetics Program, Skirball Institute at NYU Medical School, New York, NY 10016, USA
    Development 128:983-91. 2001
    ..We propose that spatially restricted phospholipid hydrolysis creates a gradient of signal necessary and specific for the migration and survival of germ cells...
  15. pmc Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion
    Anne Pacquelet
    European Molecular Biology Laboratory EMBL, 69117 Heidelberg, Germany
    J Cell Biol 170:803-12. 2005
    ..We generated multiple fusions between DE-cadherin and alpha-catenin as well as point-mutated beta-catenin and analyzed their ability to support these types of adhesion...
  16. ncbi pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
    E Brunner
    Zoologisches Institut der Universitat Zurich, Switzerland
    Nature 385:829-33. 1997
    ..studies indicate that the vertebrate HMG-domain proteins Lef-1 and XTcf-3 can physically interact with beta-catenin, a homologue of Drosophila Armadillo (Arm), the most downstream component known in the Wnt signal transduction ..
  17. ncbi wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo
    M Peifer
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280
    Development 120:369-80. 1994
    ..Drosophila Armadillo, homolog of vertebrate beta-catenin, is required for wingless signaling...
  18. ncbi Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
    M van de Wetering
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Cell 88:789-99. 1997
    ..transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer binding factor) interact with beta-catenin and are hypothesized to mediate Wingless/Wnt signaling...
  19. ncbi The Drosophila AP axis is polarised by the cadherin-mediated positioning of the oocyte
    A González-Reyes
    The Wellcome CRC Institute and Department of Genetics, University of Cambridge, Cambridge CB2 1QR, UK
    Development 125:3635-44. 1998
    ..cell rearrangement, the components of the homophilic cadherin adhesion complex, DE-cadherin, Armadillo and alpha-catenin, accumulate along the border between the oocyte and the posterior follicle cells...
  20. pmc Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    J Cell Biol 150:1361-74. 2000
    ..This study is the first functional analysis of an atypical protein kinase C isoform using a loss-of-function allele in a genetically tractable organism...
  21. ncbi Linking colorectal cancer to Wnt signaling
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 103:311-20. 2000
  22. ncbi Developmental roles and molecular characterization of a Drosophila homologue of Arabidopsis Argonaute1, the founder of a novel gene superfamily
    Y Kataoka
    Department of Biophysics, School of Science, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Genes Cells 6:313-25. 2001
    ..However, little has been reported about their roles in animal development or about the molecular activities of any of the members...
  23. ncbi Planar polarity and actin dynamics in the epidermis of Drosophila
    Julia A Kaltschmidt
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Nat Cell Biol 4:937-44. 2002
    ..We show that Wingless (Wg) signalling and Jun amino-terminal kinase (JNK) signalling have overlapping but different roles in these events...
  24. ncbi Armadillo/beta-catenin-dependent Wnt signalling is required for the polarisation of epidermal cells during dorsal closure in Drosophila
    Veronique Morel
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Development 131:3273-83. 2004
    ..We find that the beta-catenin-dependent Wingless signalling pathway is required for polarisation of the DME cells...
  25. ncbi Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc
    Chun Han
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 132:667-79. 2005
    ..We propose that Wg establishes its concentration gradient by a restricted diffusion mechanism involving Dally and Dlp in the wing disc...
  26. ncbi The adult Drosophila posterior midgut is maintained by pluripotent stem cells
    Benjamin Ohlstein
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, Maryland 21218, USA
    Nature 439:470-4. 2006
    ..The identification of Drosophila intestinal stem cells with striking similarities to their vertebrate counterparts will facilitate the genetic analysis of normal and abnormal intestinal function...
  27. doi Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 423, New York, NY 10021, USA
    J Cell Sci 123:3157-65. 2010
    ..We conclude that apical-basal proteins, used to establish polarity within a cell, can be independently co-opted to function in epithelial morphogenesis...
  28. pmc Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
    David M Roberts
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Biol Cell 22:1845-63. 2011
    ..Acting in the "destruction complex" with Axin, glycogen synthase kinase 3, and casein kinase, APC targets ßcatenin (ßcat) for phosphorylation and recognition by an E3 ubiquitin-ligase...
  29. ncbi Domain-specific early and late function of Dpatj in Drosophila photoreceptor cells
    Sang Chul Nam
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas
    Dev Dyn 235:1501-7. 2006
    ..Our study provides evidence that Dpatj has domain-specific early and late functions in regulating the localization and stability of the Crb-Sdt complex in photoreceptor cells...
  30. pmc The Hippo pathway regulates apical-domain size independently of its growth-control function
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:2360-70. 2009
    ..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms...
  31. ncbi The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions
    F Grawe
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Development 122:951-9. 1996
    ..the ultrastructural level are preceded by a misdistribution of Armadillo and DE-cadherin, the homologues of beta-catenin and E-cadherin, respectively, which are two constituents of the vertebrate adherens junctions...
  32. ncbi Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants
    A Sato
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 126:4421-30. 1999
    ..Although Dfrizzled-3 was capable of binding to Wingless in vitro, Wingless-dependent Armadillo/beta -catenin stabilization occurred much less effectively in Drosophila cells transfected with Dfrizzled-3 than in those with ..
  33. ncbi Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity
    Nicholas S Tolwinski
    Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 4:407-18. 2003
    ..The intracellular pathway bypasses Gsk3beta/Zw3, the kinase normally required for controlling beta-catenin/Armadillo levels, suggesting that modulated degradation of Armadillo is not required for Wnt signaling...
  34. ncbi The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium
    Hélène Doerflinger
    The Wellcome Trust Cancer Research UK Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Development 130:3965-75. 2003
    ..Although the direct targets of PAR-1 are unknown, we suggest that it functions by regulating the plus ends, possibly by capping them at the basal cortex...
  35. pmc Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled
    Elizabeth E Grevengoed
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:1267-79. 2003
    ..We also examined other actin regulators. Loss of Abl leads to changes in the localization of the Arp2/3 complex and the formin Diaphanous, and mutations in diaphanous or capping protein beta enhance abl phenotypes...
  36. doi A two-tiered mechanism for stabilization and immobilization of E-cadherin
    Matthieu Cavey
    Institut de Biologie du Développment de Marseille Luminy, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Nature 453:751-6. 2008
    ..in particular its trans-association in homophilic complexes supported by actin filaments through beta- and alpha-catenin. How alpha-catenin dynamic interactions between E-cadherin/beta-catenin and cortical actin control both stability ..
  37. ncbi Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by wingless
    B Riggleman
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Cell 63:549-60. 1990
    armadillo (arm) is one of a group of Drosophila segment polarity genes that are required for normal patterning within the embryonic segment...
  38. ncbi folded gastrulation, cell shape change and the control of myosin localization
    Rachel E Dawes-Hoang
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, NJ 08544, USA
    Development 132:4165-78. 2005
    ..Our analysis of fog function therefore provides a direct link from patterning to cell shape change...
  39. pmc Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis
    Muriel Grammont
    Institut National de la Sante et de la Recherche Medicale, Unité 384, Clermont Ferrand F 63001, France
    J Cell Biol 177:139-50. 2007
    ..This provides new evidence that Notch, besides playing a key role in cell differentiation, also controls cell morphogenesis...
  40. doi The activation potential of MOF is constrained for dosage compensation
    Matthias Prestel
    Adolf Butenandt Institute and Centre for Integrated Protein Science, Ludwig Maximilians University, 80336 Munich, Germany
    Mol Cell 38:815-26. 2010
    ....
  41. ncbi DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
    M Petronczki
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Cell Biol 3:43-9. 2001
    ....
  42. ncbi Myosin VI is required for E-cadherin-mediated border cell migration
    Erika R Geisbrecht
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Nat Cell Biol 4:616-20. 2002
    ..We found that E-cadherin and Armadillo (Arm, Drosophila beta-catenin) protein levels were specifically reduced in cells lacking MyoVI, whereas other proteins were not...
  43. ncbi Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in Drosophila
    Nicole Gorfinkiel
    Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK
    J Cell Sci 120:3289-98. 2007
    ..Our results show that regulated cell adhesion is a crucial element of the interactions that shape epithelial sheets in morphogenetic processes...
  44. ncbi Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS
    Y Iwai
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Sakyo ku, Japan
    Neuron 19:77-89. 1997
    ..These results suggest that processes of axon patterning critically depend on DN-cadherin-mediated axon-axon interactions...
  45. ncbi Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    J Jiang
    Howard Hughes Medical Institute, Department of Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 391:493-6. 1998
    ..Cubitus interruptus (Ci), whereas Wg signal transduction causes increased stability of Armadillo (Arm/beta-catenin), a possible co-factor for the transcriptional regulator Lef1/TCF...
  46. ncbi Roles of Armadillo, a Drosophila catenin, during central nervous system development
    J Loureiro
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Curr Biol 8:622-32. 1998
    ..Drosophila Armadillo and its vertebrate homolog beta-catenin have dual roles in epithelial cells: transducing signals from the Wingless/Wnt family of proteins and working ..
  47. pmc Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing
    David D O'Keefe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Biol 311:25-39. 2007
    ..Ras, therefore, regulates both the transcriptional responses necessary for vein cell identity, and the cell adhesive changes that determine vein and intervein cell morphology...
  48. ncbi Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin
    Rachana Tripathi
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    J Biosci 32:1133-8. 2007
    Beta-catenin is the key transducer of Wingless-type MMTV integration site family member (Wnt) signalling, upregulation of which is the cause of cancer of the colon and other tissues...
  49. pmc Synergy between bacterial infection and genetic predisposition in intestinal dysplasia
    Yiorgos Apidianakis
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:20883-8. 2009
    ..Assessment of progenitor cell responses to pathogenic intestinal bacteria could provide a measure of predisposition for apoptotic enterocyte-assisted intestinal dysplasias in humans...
  50. pmc Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin
    Marc Fiedler
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 108:1937-42. 2011
    Wnt/β-catenin signaling controls numerous steps in normal animal development and can also cause cancer if inappropriately activated...
  51. ncbi Cell adhesion molecule Echinoid associates with unconventional myosin VI/Jaguar motor to regulate cell morphology during dorsal closure in Drosophila
    Hui Ping Lin
    Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
    Dev Biol 311:423-33. 2007
    ..Consistent with this, we found that ectopic ed expression in the amnioserosa induces myosin VI/Jar-dependent apical constriction of this tissue...
  52. ncbi The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation
    M Peifer
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    Development 111:1029-43. 1991
    ..We have examined the role of the armadillo (arm) gene in this latter process...
  53. ncbi dishevelled and armadillo act in the wingless signalling pathway in Drosophila
    J Noordermeer
    Howard Hughes Medical Institute, California
    Nature 367:80-3. 1994
    ..We show that wingless acts through dishevelled and armadillo to affect the expression of the homeobox gene engrailed and cuticle differentiation...
  54. ncbi Role of oocyte position in establishment of anterior-posterior polarity in Drosophila
    A González-Reyes
    Wellcome CRC Institute, University of Cambridge, England
    Science 266:639-42. 1994
    ..Moreover, the generation of AP asymmetry requires signaling from the germ line to the soma and back again...
  55. ncbi A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis
    M Peifer
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280
    Development 118:1191-207. 1993
    ..segment polarity gene armadillo is related to the vertebrate adhesive junction components plakoglobin and beta-catenin led to the suggestion that armadillo might provide a genetic handle to study adhesive junction structure and ..
  56. ncbi Adherens junctions: new insight into assembly, modulation and function
    Ulrich Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5
    Bioessays 24:690-5. 2002
    ..4 Finally, the asymmetric distribution of adherens junction material regulates spindle orientation during asymmetric cell division in the sensory organ lineage...
  57. ncbi Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells
    Richard Benton
    The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, CB2 1QR Cambridge, United Kingdom
    Cell 115:691-704. 2003
    ..Thus, antagonism of Bazooka by PAR-1/14-3-3 may represent a general mechanism for establishing complementary cortical domains in polarized cells...
  58. pmc Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II
    Sandra G Zimmerman
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Dev Biol 340:54-66. 2010
    ..Our data suggest a novel link between canonical Wnt signaling and epithelial structure that requires activation of the Rho1 pathway and Myosin II...
  59. ncbi Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways
    Hyung Don Ryoo
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, Box 252, New York, NY 10021, USA
    Dev Cell 7:491-501. 2004
    ..These findings support a model where apoptotic cells activate signaling cascades for compensatory proliferation...
  60. ncbi Stem cells signal to the niche through the Notch pathway in the Drosophila ovary
    Ellen J Ward
    Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, School of Medicine, Box 357350, 1959 NE Pacific Street, University of Washington, Seattle, Washington 98195, USA
    Curr Biol 16:2352-8. 2006
    ..Demonstration that stem cells can contribute to niche function has far-reaching consequences for stem cell therapies and may provide insight into how cancer can spread throughout an organism via populations of cancer stem cells...
  61. ncbi Segmentation and specification of the Drosophila mesoderm
    N Azpiazu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 10:3183-94. 1996
    ..Hence, hh and wg play opposing roles in mesoderm segmentation...
  62. ncbi Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin
    F Hamada
    Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita 565 0871, Japan
    Science 283:1739-42. 1999
    Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of beta-catenin/Armadillo, which in turn activates gene transcription...
  63. pmc The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila
    A Gallet
    Labororatoire de Génétique et Physiologie du Développement, UMR 9943 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy Case 907, F 13288 Marseille, Cedex 09, France
    EMBO J 18:2208-17. 1999
    ..We discuss these results with respect to current models of Armadillo/beta-catenin action for the transmission of the Wingless/Wnt pathway.
  64. ncbi Divide and conquer: pattern formation in Drosophila embryonic epidermis
    V Hatini
    Dept Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Genet 17:574-9. 2001
    ..Here, we review several recent reports that help to elucidate the regulatory principles used to control this pattern. Because organizers are conserved, the same fundamental principles might operate in other organizers...
  65. ncbi Germline stem cells anchored by adherens junctions in the Drosophila ovary niches
    Xiaoqing Song
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Science 296:1855-7. 2002
    ..Two major components of this adhesion process, DE-cadherin and Armadillo/beta-catenin, accumulate at high levels in the junctions between GSCs and cap cells, one of the niche components...
  66. ncbi Similarities between the Hedgehog and Wnt signaling pathways
    Daniel Kalderon
    Department of Biological Sciences, Columbia University, New York NY 10027, USA
    Trends Cell Biol 12:523-31. 2002
    ..kinases silence both pathways by labeling a key transcription factor (Cubitus interruptus) or co-activator (beta-catenin) for proteolysis, and it is possible that reversal of these phosphorylation events is, in each case, central to ..
  67. ncbi Mbt, a Drosophila PAK protein, combines with Cdc42 to regulate photoreceptor cell morphogenesis
    Daniela Schneeberger
    University of Wurzburg, Institut für Medizinische Strahlenkunde und Zellforschung MSZ, Versbacherstr 5, 97078 Wurzburg, Germany
    Development 130:427-37. 2003
    ..Besides regulation of kinase activity, another important function of Cdc42 is to recruit Mbt to adherens junctions. We propose a role for Mbt as a downstream effector of Cdc42 in photoreceptor cell morphogenesis...
  68. ncbi Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus
    M Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Science 287:1606-9. 2000
  69. ncbi Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs
    Kathryn Akong
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Dev Biol 250:91-100. 2002
    ..Surprisingly, APC1 function in embryos occurs at levels of expression nearly too low to detect. Further, the overlapping functions exist despite striking differences in the intracellular localization of the two APC family members...
  70. ncbi Spatial regulation of Wingless morphogen distribution and signaling by Dally-like protein
    Catherine A Kirkpatrick
    The Developmental Biology Center, Department of Pediatrics, Department of Genetics, Cell Biology, and Development, 6 160 Jackson Hall, 321 Church Street SE, The University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 7:513-23. 2004
    ..These findings suggest that modification of an HSPG by a secreted hydrolase can control morphogen levels in the matrix...
  71. ncbi RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation
    Jörg Grosshans
    ZMBH, Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Development 132:1009-20. 2005
    ..Our results support a model in which RhoGEF2 and dia control position, shape and stability of the forming furrow canal by spatially restricted assembly of actin filaments required for the proper infolding of the plasma membrane...
  72. ncbi Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila
    Mayuko Takahashi
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 132:2547-59. 2005
    ..was found to interact genetically with shotgun, a gene encoding E-cadherin, and armadillo, a Drosophila beta-catenin. Immunoprecipitation and a pull-down assay indicated that Src42A forms a ternary complex with E-cadherin and ..
  73. ncbi The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis
    Ying Wang
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrasse 17, D 50931 Köln, Germany
    Curr Biol 17:1349-55. 2007
    ..Myosin is activated at the apical cortex by localized Rho kinase and inhibited at the basolateral cortex by PP1beta9C. In addition, our data indicate that active myosin is apically anchored by the Baz/Par-6/aPKC complex...
  74. ncbi Nonchordate classic cadherins have a structurally and functionally unique domain that is absent from chordate classic cadherins
    H Oda
    Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Kyoto Research Park, Chudoji Minami machi, Shimogyo ku, Kyoto, 600 8813, Japan
    Dev Biol 216:406-22. 1999
    ..We propose that there is a fundamental difference in the mode of classic cadherin-mediated cell-cell adhesion between chordate and nonchordate metazoans...
  75. pmc Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo
    T Lecuit
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Cell Biol 150:849-60. 2000
    ..We thus identify a tightly regulated scheme of polarized membrane insertion during cellularization. We propose that such a mechanism could participate in the progressive emergence of apical-basal polarity...
  76. pmc The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 170:813-23. 2005
    ..These results reveal key steps in the assembly of the apical domain in Drosophila...
  77. ncbi Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2 3PX, United Kingdom
    Curr Biol 17:1864-70. 2007
    ..The PCP members of the SWH network are not involved in this process, indicating that signaling upstream of Hpo varies according to developmental context...
  78. ncbi Segmental patterning of heart precursors in Drosophila
    P A Lawrence
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    Development 121:4303-8. 1995
    ..We conclude that the mesoderm is segmented in some way not dependent on the distribution of Wingless, suggesting a more permissive and less instructive role for the protein in this instance...
  79. pmc Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis
    R T Cox
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 27599 3280, USA
    J Cell Biol 134:133-48. 1996
    ..Drosophila Armadillo, the homologue of vertebrate beta-catenin, is a core component of the adherens junction protein complex and has been hypothesized to be essential for ..
  80. ncbi A new member of the frizzled family from Drosophila functions as a Wingless receptor
    P Bhanot
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 382:225-30. 1996
    ..Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules...
  81. ncbi wingless refines its own expression domain on the Drosophila wing margin
    E J Rulifson
    Program for Neuroscience, University of Wisconsin, Madison 53706, USA
    Nature 384:72-4. 1996
    ..Cells unable to receive the Wg signal do not resolve the boundary between wg-expressing and proneural cells...
  82. ncbi Nuclear access and action of notch in vivo
    G Struhl
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 93:649-60. 1998
    ....
  83. ncbi Compartment boundaries: where, why and how?
    J P Vincent
    National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    Int J Dev Biol 42:311-5. 1998
    ..Here, I review the work that demonstrated the existence of compartments. I then conjecture on why compartments exist and review the roles of various gene products in the maintenance of compartment boundaries...
  84. pmc Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis
    G Tanentzapf
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada M5S 3G5
    J Cell Biol 151:891-904. 2000
    ..Finally, we show that the cadherin-catenin complex is not required for the formation of the follicular epithelium, but only for its maintenance...
  85. ncbi The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye
    N E Baker
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cell 104:699-708. 2001
    ..Through proliferation and survival control, such signals couple the total number of uncommitted cells being generated to the neural patterning of the retina...
  86. pmc All Tcf HMG box transcription factors interact with Groucho-related co-repressors
    H Brantjes
    Department of Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nucleic Acids Res 29:1410-9. 2001
    ..Upon Wingless/Wnt signalling, beta-catenin translocates to the nucleus, interacts with Tcf (1-3) and thus activates transcription of target genes (4,5)...
  87. pmc Naked cuticle targets dishevelled to antagonize Wnt signal transduction
    R Rousset
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 15:658-71. 2001
    ..Our results suggest that Nkd acts directly through Dsh to limit Wg activity and thus determines how efficiently Wnt signals stabilize Armadillo (Arm)/beta-catenin and activate downstream genes.
  88. pmc The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation
    N Barker
    Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    EMBO J 20:4935-43. 2001
    Wnt-induced formation of nuclear Tcf-beta-catenin complexes promotes transcriptional activation of target genes involved in cell fate decisions...
  89. ncbi Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia
    Salim Abdelilah-Seyfried
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
    Development 130:1927-35. 2003
    ....
  90. ncbi PVF1, a PDGF/VEGF homolog, is sufficient to guide border cells and interacts genetically with Taiman
    Jocelyn A McDonald
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Development 130:3469-78. 2003
    ..In addition, we find that taiman and Pvf1 regulate the dynamic localization of E-cadherin in the border cells, possibly accounting for the interaction between these two pathways...
  91. pmc A nuclear function for armadillo/beta-catenin
    Nicholas S Tolwinski
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Biol 2:E95. 2004
    ..Wnt binding to its receptor causes the stabilization and nuclear localization of beta-catenin. Nuclear beta-catenin then functions to activate transcription in conjunction with the transcription factor TCF...
  92. ncbi Junctions and vesicular trafficking during Drosophila cellularization
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Developpement de Marseille, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    J Cell Sci 117:3427-33. 2004
    ..The novel proteins Nullo and Slam, which are specifically induced during cellularization, represent developmental regulators of membrane growth during cellularization...
  93. ncbi Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components
    Sunil Q Mehta
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 46:219-32. 2005
    ..The data also show that functions of other exocyst components persist in the absence of sec15, suggesting that different exocyst components have separable functions...
  94. ncbi Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing
    Robert J Major
    Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 132:3823-33. 2005
    ....
  95. ncbi Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway
    Katherine E Brown
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Dev Biol 300:710-21. 2006
    ..These observations define a new function for EGFR signalling in eye development and illustrate a mechanism for the control of epithelial morphology by developmental signals...
  96. pmc Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development
    Melissa A Hayden
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Dev Biol 305:358-76. 2007
    ..Finally, we propose a model suggesting that Wg signaling regulates fine scale cell fates along the anterior-posterior axis, in part by creating an adhesion gradient and consider possible alternate explanations for our observations...
  97. pmc aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Dev Cell 12:727-38. 2007
    ..aPKC apparently regulates this balance. Without aPKC, abnormally strong microtubule interactions break AJ symmetry and epithelial structure is lost...
  98. ncbi Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation
    Myriam Zecca
    Howard Hughes Medical Institute, Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 W 168th Street, New York, NY 10032, USA
    Development 134:3001-10. 2007
    ..We propose that Wg promotes the expansion of the wing primordium following the D-V segregation by fueling this non-autonomous autoregulatory mechanism...
  99. pmc Cellular behavior in the developing Drosophila pupal retina
    David E Larson
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, Saint Louis, MO 63110, USA
    Mech Dev 125:223-32. 2008
    ..Finally, we establish a role for the adherens junction regulator P120-Catenin in retinal patterning through its regulation of normal adherens junction integrity...
  100. doi Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis
    Catarina C F Homem
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Development 135:1005-18. 2008
    ..These effects also are mediated through coordinated effects on myosin activity and adhesion, suggesting a common mechanism for Diaphanous action during morphogenesis...
  101. pmc Inhibition of Drosophila Wg signaling involves competition between Mad and Armadillo/beta-catenin for dTcf binding
    Yi Arial Zeng
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    PLoS ONE 3:e3893. 2008
    ..In vitro binding studies revealed competition for dTcf binding between Mad and the Wnt effector beta-catenin/Armadillo (Arm)...

Research Grants24

  1. Wnt and beta-Catenin Signaling in Development/Disease
    Mariann Bienz; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): The Wnt/[unreadable]-catenin pathway is a highly conserved signaling cascade that plays key roles during animal development...
  2. TISSUE SPECIFICITY OF WINGLESS SIGNALING IN DROSOPHILA
    Kenneth Cadigan; Fiscal Year: 2005
    ..Since the machinery for Wnt signal transduction is also evolutionarily conserved, understanding tissue specific mechanisms of Wg signaling in flies should have broad relevance to other organisms. ..
  3. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
  4. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  5. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
    ..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
  6. Novel Cilia Trafficking Mechanisms
    BENJAMIN L MARGOLIS; Fiscal Year: 2010
    ..Cystic diseases of the kidney, where the normal kidney is replaced by non-functioning fluid filled cysts, are a major cause of kidney failure. ..
  7. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....
  8. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  9. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
  10. Tight Junction Proteins and Epithelial Polarity
    Benjamin Margolis; Fiscal Year: 2009
    ..These studies will shed new light on the processes necessary for early epithelial polarization and have important implication for renal epithelial function in health and disease. ..
  11. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
    ..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
  12. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2009
    ..In the canonical pathway, the beta-catenin protein is a vital effector, with certain Wnt ligands (e.g., Wnt-1) acting to stabilize beta-catenin...
  13. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
    ..Our work in Drosophila on the mechanisms and targets of these regulators' action will provide insight as to the underlying causes of these diseases and will help to reveal potential therapies. ..
  14. Transgenic analysis of Smad tumor suppressor genes
    Stuart Newfeld; Fiscal Year: 2006
    ..This knowledge can be used to determine if Smad proteins should be exploited as anti-cancer drug discovery targets. ..
  15. A Drosophila Model for Angelman Syndrome
    Janice Fischer; Fiscal Year: 2006
    ..Overexpression of wild-type CG6190 in the Drosophila eye results in a severe mutant phenotype. Modifiers of the eye phenotype will be isolated and the mutant genes identified. ..
  16. Model Organisms and Approaches in Developmental Biology
    Ruth Lehmann; Fiscal Year: 2005
    ..3) Providing an open forum for discussion on current topics in developmental biology of relevance to education and science policy in the participating countries and the Western Hemisphere. ..
  17. Organogenesis Screen Using Tissue-Specific Zebrafish
    Jau Nian Chen; Fiscal Year: 2005
    ..Mutations identified from this screen will provide entry points to dissect genetic and molecular pathways involved in vertebrate organogenesis. ..
  18. Eye Development: Molecular Genetics of Nuclear Migration
    Janice Fischer; Fiscal Year: 2005
    ..Finally, a variety of different genetic screening approaches will be used to identify additional genes in the klarsicht/egk1 pathway. ..
  19. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  20. A Drosophilia Model of Amyotrophic Lateral Schlerosis
    Stephen Jackson; Fiscal Year: 2004
    ..Results from this work should clarify the normal cellular role of the ALS2 gene and may reveal strategies for treatment of ALS disease. ..
  21. Mechanisms governing polarity in Drosophila oogenesis
    Daniel Kalderon; Fiscal Year: 2004
    ....
  22. Molecular Genetics of Polyglutamine-Induced Degeneration
    George Jackson; Fiscal Year: 2003
    ..abstract not available ..
  23. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
    ..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..
  24. Conference on Wnt and Beta Catenin Signaling
    Randall Moon; Fiscal Year: 2002
    ..The Wnt signaling pathway that activates B-catenin exemplifies this principle...