Appl

Summary

Gene Symbol: Appl
Description: beta amyloid protein precursor-like
Alias: APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\CG7727, EG:65F1.5, appl, dAbeta, CG7727 gene product from transcript CG7727-RE, APP-like, Appl-PA, Appl-PB, Appl-PC, Appl-PD, Appl-PE, Appl-PF, CG7727-PA, CG7727-PB, CG7727-PC, CG7727-PD, CG7727-PE, CG7727-PF, amyloid Precursor-Like protein, amyloid precursor protein, amyloid precursor protein-like, beta-amyloid-protein-precursor-like
Species: fruit fly

Top Publications

  1. ncbi Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor
    L Q Luo
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    J Neurosci 10:3849-61. 1990
  2. doi Identifying genes that interact with Drosophila presenilin and amyloid precursor protein
    Diana L van de Hoef
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Genesis 47:246-60. 2009
  3. pmc Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function
    Katia Carmine-Simmen
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Neurobiol Dis 33:274-81. 2009
  4. pmc Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP
    Casper Groth
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Bluemle Life Sciences Building 830A, 233 South 10 Street, Philadelphia, PA 19107, USA
    Mol Pharmacol 77:567-74. 2010
  5. pmc Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo
    Leila M Luheshi
    Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 8:e1000334. 2010
  6. ncbi Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes
    Airong Li
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02128, USA
    Hum Mol Genet 16:2626-39. 2007
  7. pmc Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease
    Oyinkan Sofola
    Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing and Research, University College London, London, United Kingdom
    PLoS Genet 6:e1001087. 2010
  8. doi Drosophila amyloid precursor protein-like is required for long-term memory
    Valérie Goguel
    Genes and Dynamics of Memory Systems, Neurobiology Unit, Centre National de la Recherche Scientifique, Ecole Superieure de Physique et de Chimie Industrielles, 75005 Paris, France
    J Neurosci 31:1032-7. 2011
  9. pmc Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration
    Jill S Wentzell
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neurobiol Dis 46:78-87. 2012
  10. pmc Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
    Maarten Leyssen
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB and University of Leuven, School of Medicine, Leuven, Belgium
    EMBO J 24:2944-55. 2005

Research Grants

Scientific Experts

  • Pedro Fernandez-Funez
  • Paul C R Hopkins
  • Diego E Rincon-Limas
  • Lawrence Goldstein
  • Gunter Merdes
  • M E Fortini
  • Kim D Finley
  • Parsa Kazemi-Esfarjani
  • Doris Kretzschmar
  • Isabelle Bourdet
  • Valérie Goguel
  • Thomas Preat
  • Bonnie J Bolkan
  • Burkhard Poeck
  • Bassem A Hassan
  • Katia Carmine-Simmen
  • K White
  • Liqun Yuan
  • Matthew R Blake
  • Michael F Wangler
  • Xingjun Wang
  • L Torroja
  • Carole Weaver
  • Garrett G Gross
  • Jillian L Shaw
  • Aurélie Lampin-Saint-Amaux
  • Natalia Mora
  • Yanshan Fang
  • Vasiliki Michaki
  • Jaskirat Singh
  • Jill S Wentzell
  • Moria C Chambers
  • Ayako Tonoki
  • Meghana Tare
  • Konrad Beyreuther
  • Roland Strauss
  • Tilman Triphan
  • Leila M Luheshi
  • Denise Stempfle
  • Oyinkan Sofola
  • Casper Groth
  • Masaki Sone
  • Sheryl T Smith
  • Diana L van de Hoef
  • Jakob Andreas Tschäpe
  • Mary Konsolaki
  • Bart De Strooper
  • Dan Garza
  • Momoko Hase
  • Fumika N Hamada
  • Anthony R White
  • Derya Ayaz
  • Hidenori Taru
  • Weihuan Cao
  • Patricia Rusu
  • H J Kim
  • Airong Li
  • S P Koushika
  • Albéna Pramatarova
  • H Chu
  • Maarten Leyssen
  • James Ashley
  • Pankaj Kapahi
  • Isabell Greeve
  • Yan Li
  • Natalie De Geest
  • Annelies Claeys
  • Shu Hu
  • Eric Bellefroid
  • Jiekun Yan
  • Zeynep Okray
  • Xi Ren
  • Xiao Jiang Quan
  • Yingyao Shao
  • CHANGYAN CHEN
  • Yu Zhao
  • Yujun Chen
  • Hugo J Bellen
  • Joanna Kotwica-Rolinska
  • Lei Xue
  • Scott D Holbrook
  • Yeqing Ma
  • Shinya Yamamoto
  • Jadwiga M Giebultowicz
  • Eileen S Chow
  • Yujia Hu
  • Toshiharu Suzuki
  • Gerd Multhaup
  • Ansgar Klebes
  • Roberto Cappai

Detail Information

Publications67

  1. ncbi Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor
    L Q Luo
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    J Neurosci 10:3849-61. 1990
    A Drosophila gene [amyloid protein precursor-like (Appl)] has recently been identified whose predicted amino acid sequence (APPL) shares extensive homology with the beta-amyloid protein precursor (APP) associated with Alzheimer's disease...
  2. doi Identifying genes that interact with Drosophila presenilin and amyloid precursor protein
    Diana L van de Hoef
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Genesis 47:246-60. 2009
    ..transmembrane proteins such as Notch and one of the genes targeted in Alzheimer's disease known as amyloid precursor protein (APP)...
  3. pmc Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function
    Katia Carmine-Simmen
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Neurobiol Dis 33:274-81. 2009
    ..While amyloid precursor protein (APP)-related proteins are found in most organisms, only Abeta fragments from human APP have been shown ..
  4. pmc Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP
    Casper Groth
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Bluemle Life Sciences Building 830A, 233 South 10 Street, Philadelphia, PA 19107, USA
    Mol Pharmacol 77:567-74. 2010
    ..protease is responsible for the cleavage of numerous type I integral membrane proteins, including amyloid precursor protein (APP) and Notch...
  5. pmc Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo
    Leila M Luheshi
    Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 8:e1000334. 2010
    ..Here we study the effects of modulating this balance for the amyloid-beta (Abeta) peptide by using a small engineered binding protein (Z(Abeta3)) that binds with nanomolar affinity to Abeta, ..
  6. ncbi Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes
    Airong Li
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02128, USA
    Hum Mol Genet 16:2626-39. 2007
    ..Finally, co-overexpression of dUbqln and the human amyloid precursor protein (APP) in the eye significantly reduced the levels of full-length APP and its C-terminal fragment...
  7. pmc Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease
    Oyinkan Sofola
    Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing and Research, University College London, London, United Kingdom
    PLoS Genet 6:e1001087. 2010
    b>Abeta peptide accumulation is thought to be the primary event in the pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the hyperphosphorylation of tau protein...
  8. doi Drosophila amyloid precursor protein-like is required for long-term memory
    Valérie Goguel
    Genes and Dynamics of Memory Systems, Neurobiology Unit, Centre National de la Recherche Scientifique, Ecole Superieure de Physique et de Chimie Industrielles, 75005 Paris, France
    J Neurosci 31:1032-7. 2011
    The amyloid precursor protein (APP) plays an important role in Alzheimer's disease (AD), a progressive neurodegenerative pathology that first manifests as a decline of memory...
  9. pmc Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration
    Jill S Wentzell
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neurobiol Dis 46:78-87. 2012
    ..Here we describe a neuroproprotective function of APP and fly APPL (Amyloid Precursor Protein-like) in vivo in several Drosophila mutants with progressive neurodegeneration...
  10. pmc Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
    Maarten Leyssen
    Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology VIB and University of Leuven, School of Medicine, Leuven, Belgium
    EMBO J 24:2944-55. 2005
    ..The amyloid precursor protein (APP) is involved in the pathogenesis of Alzheimer's disease (AD)...
  11. ncbi Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint
    James Ashley
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 25:5943-55. 2005
    ..FasII levels in the presynaptic and postsynaptic cell and requires the presence of the fly homolog of amyloid precursor protein (APPL)...
  12. pmc Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila
    Gunter Merdes
    ZMBH, University of Heidelberg, Heidelberg, Germany
    EMBO J 23:4082-95. 2004
    ..challenged by recent evidence from different model systems, which attribute numerous functions to the amyloid precursor protein (APP)...
  13. ncbi Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila
    Isabell Greeve
    Center for Molecular Neurobiology, University of Hamburg, 20251 Hamburg, Germany
    J Neurosci 24:3899-906. 2004
    Beta-amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical role in Alzheimer's disease (AD) pathophysiology...
  14. pmc The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing
    Jakob Andreas Tschäpe
    Lehrstuhl für Entwicklungsbiologie, Universitätsstr 31, Universitat Regensburg, D 93053 Regensburg, Germany
    EMBO J 21:6367-76. 2002
    ..In addition, the degenerative phenotype of loe is enhanced by a mutation in amyloid precursor protein-like (APPL), the fly homolog of the human amyloid precursor protein involved in Alzheimer's disease...
  15. doi Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein
    Carole Weaver
    Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Traffic 14:295-308. 2013
    ..is a required negative regulator of both kinesin-1-mediated and dynein-mediated axonal transport of the amyloid precursor protein (APP), a key contributor to AD pathology...
  16. ncbi Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade
    Hidenori Taru
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:20070-8. 2002
    ..a novel protein based on its association with Drosophila APP-like protein (APPL), a homolog of the beta-amyloid precursor protein (APP) that is implicated in Alzheimer's disease...
  17. ncbi The Drosophila transcript encoded by the beta-amyloid protein precursor-like gene is restricted to the nervous system
    L E Martin-Morris
    Department of Biology, Brandeis University, Waltham, MA 02254
    Development 110:185-95. 1990
    We have molecularly delineated a Drosophila beta-amyloid protein precursor-like (Appl) gene and analyzed its pattern of expression...
  18. pmc A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor
    D R Rosen
    Department of Biology, Brandeis University, Waltham, MA 02254
    Proc Natl Acad Sci U S A 86:2478-82. 1989
    We have isolated genomic and cDNA clones for a Drosophila gene resembling the human beta-amyloid precursor protein (APP). This gene produces a nervous system-enriched 6.5-kilobase transcript. Sequencing of cDNAs derived from the 6...
  19. ncbi Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene
    L Luo
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    Neuron 9:595-605. 1992
    Drosophila amyloid precursor protein-like (Appl) gene encodes a protein product (APPL) similar to beta-amyloid precursor protein (APP) associated with Alzheimer's disease...
  20. ncbi APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons
    L Torroja
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    J Neurosci 16:4638-50. 1996
    ..Amino acid comparisons show that APPL protein is a member of the amyloid precursor protein (APP)-like family of proteins...
  21. ncbi Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer
    M E Fortini
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Genet 16:161-7. 2000
    ..With the advent of complete genomic sequencing on the horizon, Drosophila will continue to be an outstanding model system in which to unravel the complexities, causes and treatments for human neural degeneration...
  22. pmc Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesis
    H Chu
    Biochemistry Department, Brandeis University, Waltham, Massachusetts 02454 9110 USA
    Genes Dev 12:3613-24. 1998
    ..Our results are discussed in the context of the current evidence in dorsoventral patterning in the Drosophila neuroectoderm...
  23. ncbi Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport
    L Torroja
    Department of Biology, Center for Complex Systems, MS 008, Brandeis University Waltham, Massachusetts, 02454, USA
    Curr Biol 9:489-92. 1999
    ..disease, amyloid plaques and neurofibrillary tangles, involve two apparently unrelated proteins, the amyloid precursor protein (APP) and Tau...
  24. ncbi Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila
    S Gunawardena
    Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0683, USA
    Neuron 32:389-401. 2001
    We tested the hypothesis that amyloid precursor protein (APP) and its relatives function as vesicular receptor proteins for kinesin-I...
  25. ncbi Specific functions of Drosophila amyloid precursor-like protein in the development of nervous system and nonneural tissues
    Yan Li
    Laboratory of Visual Information Processing, Center for Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang Dist, 15 Datun Rd, Beijing 100101, People s Republic of China
    J Neurobiol 61:343-58. 2004
    Drosophila amyloid precursor-like protein (APPL) is expressed extensively in the nervous system soon after neuronal differentiation...
  26. ncbi The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction
    L Torroja
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 19:7793-803. 1999
    Although abnormal processing of beta-amyloid precursor protein (APP) has been implicated in the pathogenic cascade leading to Alzheimer's disease, the normal function of this protein is poorly understood...
  27. pmc Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila
    Matthew R Blake
    Department of Integrative Biology, Oregon State University, Corvallis, OR 97331, USA
    Neurobiol Dis 77:117-26. 2015
    ..While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing the neurotoxic Amyloid-β (Aβ) peptide plays a fundamental role in AD pathogenesis...
  28. pmc The Drosophila neurogenin Tap functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance
    Liqun Yuan
    VIB Center for the Biology of Disease, VIB, Leuven 3000, Belgium Center for Human Genetics, University of Leuven School of Medicine, Leuven 3000, Belgium Program in Molecular and Developmental Genetics, Doctoral School for Biomedical Sciences, University of Leuven School of Medicine, Leuven 3000, Belgium
    Development 143:2760-6. 2016
    ..Genetic and expression analyses suggest that Tap inhibits excessive axonal growth by fine regulation of the levels of the Wnt signaling adaptor protein Dishevelled. ..
  29. pmc Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila
    Isabelle Bourdet
    Genes and Dynamics of Memory Systems, Brain Plasticity Unit, CNRS, ESPCI ParisTech, PSL Research University, 10 rue Vauquelin, 75005 Paris, France
    PLoS ONE 10:e0135741. 2015
    The amyloid precursor protein (APP) plays a central role in Alzheimer's disease (AD)...
  30. pmc Modeling the complex pathology of Alzheimer's disease in Drosophila
    Pedro Fernandez-Funez
    McKnight Brain Institute, Department of Neurology, University of Florida, Gainesville, FL 32611, USA Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32611, USA Genetics Institute, University of Florida, Gainesville, FL 32611, USA Electronic address
    Exp Neurol 274:58-71. 2015
    ..genes that promote the accumulation of the amyloid-β (Aβ42) peptide revealed the critical role of amyloid precursor protein (APP) processing in AD...
  31. doi The full-length form of the Drosophila amyloid precursor protein is involved in memory formation
    Isabelle Bourdet
    Genes and Dynamics of Memory Systems, Brain Plasticity Unit, CNRS, ESPCI ParisTech, PSL Research University, 75005 Paris, France
    J Neurosci 35:1043-51. 2015
    ..In Drosophila, we recently showed that APPL, the fly APP ortholog, is required for associative memory...
  32. pmc β-secretase cleavage of the fly amyloid precursor protein is required for glial survival
    Bonnie J Bolkan
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 32:16181-92. 2012
    ..Consequently, the lack of BACE1 prevents β-processing of the amyloid precursor protein and Aβ production, which made it a promising target for drug development...
  33. pmc How the fly balances its ability to combat different pathogens
    Moria C Chambers
    Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
    PLoS Pathog 8:e1002970. 2012
    ..In addition, increased phagocytic activity is beneficial during S. pneumoniae infection but detrimental during L. monocytogenes infection, demonstrating an inherent trade-off in the immune response...
  34. doi APLP1 promotes dFoxO-dependent cell death in Drosophila
    Xingjun Wang
    Institute of Intervention Vessel, Shanghai 10th People s Hospital, Shanghai Key Laboratory of Signaling and Diseases Research, School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai, 200092, China
    Apoptosis 20:778-86. 2015
    The amyloid precursor like protein-1 (APLP1) belongs to the amyloid precursor protein family that also includes the amyloid precursor protein (APP) and the amyloid precursor like protein-2 (APLP2)...
  35. pmc Fruit flies in biomedical research
    Michael F Wangler
    Department of Molecular and Human Genetics, Baylor College of Medicine BCM, Houston, Texas 77030 Department of Pediatrics, Baylor College of Medicine BCM, Houston, Texas 77030 Jan and Dan Duncan Neurological Research Institute, Texas Children s Hospital, Houston, Texas 77030
    Genetics 199:639-53. 2015
    ..We would like to promote a better collaboration between Drosophila geneticists/biologists and human geneticists/bioinformaticians/clinicians, as it would benefit both fields and significantly impact the research on human diseases. ..
  36. pmc Design and implementation of in vivo imaging of neural injury responses in the adult Drosophila wing
    Yanshan Fang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Protoc 8:810-9. 2013
    ..Thus, the key preparation steps for in vivo imaging of the neural injury response described in this protocol can be completed within 30 min...
  37. pmc X11/Mint genes control polarized localization of axonal membrane proteins in vivo
    Garrett G Gross
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 33:8575-86. 2013
    ..we report that Drosophila X11/Mint proteins are required for targeting several proteins, including human amyloid precursor protein (APP) and Drosophila APP-like protein (APPL), to axonal membranes and for their exclusion from dendrites ..
  38. pmc Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling
    Jillian L Shaw
    Zilkha Neurogenetic Institute and Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America Neuroscience Graduate Program, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 9:e1003792. 2013
    ..gain insights into the role of DSCR1 in AD, we explored the functional interaction between DSCR1 and the amyloid precursor protein (APP), which is known to cause AD when duplicated or upregulated in DS...
  39. pmc Expression profiling of Drosophila imaginal discs
    Ansgar Klebes
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Genome Biol 3:RESEARCH0038. 2002
    ..To identify genes that establish and express the different states of determination in discs and larval tissues, we used DNA microarrays to analyze mRNAs isolated from single imaginal discs...
  40. pmc An internal thermal sensor controlling temperature preference in Drosophila
    Fumika N Hamada
    National Center for Behavioral Genomics, Volen Center for Complex Systems, Biology Department, Brandeis University MS 008, 415 South Street, Waltham, Massachusetts 02454, USA
    Nature 454:217-20. 2008
    ..This provides a potentially general strategy for robustly selecting a narrow temperature range optimal for survival...
  41. ncbi Expression and characterization of the Drosophila X11-like/Mint protein during neural development
    Momoko Hase
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Neurochem 81:1223-32. 2002
    ..X11-like (X11L) protein was originally isolated as a protein bound to the cytoplasmic domain of the beta-amyloid precursor protein (APP), which is associated with Alzheimer's disease...
  42. pmc In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity
    Denise Stempfle
    Department of Biosystems Science and Engineering, ETH Zurich, Mattenstr 26, 4058 Basel, Switzerland
    Mol Cell Biol 30:3165-75. 2010
    ..activity of reconstituted gamma-secretase toward different substrates, including markedly reduced cleavage of some APP family members compared to cleavage of the Notch receptor...
  43. doi β amyloid protein precursor-like (Appl) is a Ras1/MAPK-regulated gene required for axonal targeting in Drosophila photoreceptor neurons
    Natalia Mora
    Departament de Genetica, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona IBUB, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Cell Sci 126:53-9. 2013
    ..search for genes required for Drosophila R7 photoreceptor development we found β amyloid protein precursor-like (Appl), the ortholog of human APP, which is a key factor in the pathogenesis of Alzheimer's disease...
  44. pmc Kinesin molecular motors: transport pathways, receptors, and human disease
    L S Goldstein
    Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0683, USA
    Proc Natl Acad Sci U S A 98:6999-7003. 2001
    ..A second candidate, amyloid precursor protein, is proposed to link kinesin-I to a different, also unknown, class of axonal vesicles...
  45. doi Analysis of amyloid precursor protein function in Drosophila melanogaster
    Burkhard Poeck
    Institut fur Zoologie III Neurobiologie, Johannes Gutenberg Universitat Mainz, Colonel Kleinmann Weg 2, 55099 Mainz, Germany
    Exp Brain Res 217:413-21. 2012
    ..elegans APL-1 protein is lethal, flies lacking APPL (Amyloid Precursor Protein-like) are viable but show synaptic defects and behavioral abnormalities...
  46. pmc Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization
    Vasiliki Michaki
    Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, KU Leuven, 3000 Leuven, Belgium
    J Biol Chem 287:1100-11. 2012
    ..Reduced Abca2 levels in mammalian cells in vitro, in Drosophila melanogaster and in mice resulted in altered γ-secretase processing of APP, and thus Aβ generation, without affecting Notch cleavage.
  47. pmc Activation of JNK signaling mediates amyloid-ß-dependent cell death
    Meghana Tare
    Department of Biology, University of Dayton, Dayton, Ohio, United States of America
    PLoS ONE 6:e24361. 2011
    ..However, the exact mechanisms leading to cell death are not clearly understood...
  48. pmc Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages
    Jaskirat Singh
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine and Graduate School of Biological Sciences, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Cell 23:82-96. 2012
    ..with its role in Psn processing, Hbs genetically interacts with the Drosophila β-amyloid protein precursor-like (Appl) protein, the homolog of mammalian APP, the cleavage of which is associated with Alzheimer's disease...
  49. pmc vnd, a gene required for early neurogenesis of Drosophila, encodes a homeodomain protein
    F Jimenez
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma, CSIC, Madrid, Spain
    EMBO J 14:3487-95. 1995
    ..We discuss these findings within the framework of early Drosophila neurogenesis and the known phenotypes associated with the vnd locus...
  50. pmc A survey of human disease gene counterparts in the Drosophila genome
    M E Fortini
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 150:F23-30. 2000
  51. pmc The neuron-enriched splicing pattern of Drosophila erect wing is dependent on the presence of ELAV protein
    S P Koushika
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    Mol Cell Biol 20:1836-45. 2000
    ..Additionally, we report that ELAV promotes a neuron-enriched splice isoform of Drosophila armadillo transcript. ELAV, however, is not involved in all neuron-enriched splice events...
  52. ncbi Biomedicine. Nota bene. In the nic of time
    O Smith
    Science 294:2118. 2001
  53. ncbi Neural disease: Drosophila degenerates for a good cause
    M Mutsuddi
    Biology Department, Morrill Science Center, University of Massachusetts, Amherst 01003, USA
    Curr Biol 8:R809-11. 1998
    ..Recent studies suggest that molecular genetic approaches in Drosophila may shed important new light on conserved mechanisms underlying such disorders...
  54. ncbi Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein
    Anthony R White
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Neurosci 22:365-76. 2002
    The amyloid precursor protein (APP) of Alzheimer's disease (AD) has a copper binding domain (CuBD) located in the N-terminal cysteine-rich region that can strongly bind copper(II) and reduce it to Cu(I) in vitro...
  55. ncbi ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform
    S P Koushika
    Biology Department, Brandeis University, Waltham, Massachusetts 02254, USA
    Curr Biol 6:1634-41. 1996
    ..The ELAV protein is expressed exclusively in neurons, and is important for the formation and maintenance of the nervous system...
  56. doi Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization
    Sheryl T Smith
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Dev Biol 328:518-28. 2009
    ..These findings suggest that CTCF plays more active roles in regulating gene activity and it functions differently from other insulator proteins in organizing the Drosophila genome...
  57. ncbi Evidence for a copper-binding superfamily of the amyloid precursor protein
    Andreas Simons
    ZMBH Center for Molecular Biology, University of Heidelberg, Im Neuenheimer Feld 282, D 69120 Heidelberg, Germany
    Biochemistry 41:9310-20. 2002
    The amyloid precursor protein (APP) copper-binding domain (CuBD) has been shown to reduce Cu(II) to Cu(I) and to mediate copper-induced oxidation in vitro...
  58. ncbi Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1
    Parsa Kazemi-Esfarjani
    Department of Physiology and Biophysics, Center for Neuroscience, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA
    Hum Mol Genet 11:2657-72. 2002
    ....
  59. pmc blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration
    Kim D Finley
    Molecular and Cellular Biology Laboratory and Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Neurosci 23:1254-64. 2003
    ..The high degree of conservation between Drosophila and human bchs suggests that study of the functional pathway of BCHS and associated mutant phenotype may provide useful insights into human neurodegenerative disorders...
  60. pmc Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    Pankaj Kapahi
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 14:885-90. 2004
    ..Modulation of expression in the fat is sufficient for the lifespan-extension effects. The lifespan extensions are dependent on nutritional condition, suggesting a possible link between the TOR pathway and dietary restriction...
  61. pmc Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model
    Albéna Pramatarova
    Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, 35 Convent Dr, Bethesda, MD 20892, USA
    Mol Cell Biol 26:1510-7. 2006
    ..Furthermore, we observed that a loss-of-function allele of amyloid precursor protein (APP)-like, a kinesin cargo receptor, enhanced the severity of a Dab1 overexpression phenotype ..
  62. doi Aging causes distinct characteristics of polyglutamine amyloids in vivo
    Ayako Tonoki
    Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Japan
    Genes Cells 16:557-64. 2011
    ..These findings show that age-related changes in amyloid characteristics may be a trigger for late-onset polyglutamine diseases...
  63. ncbi Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development
    H J Kim
    School of Biological Science, Seoul National University, Seoul, Korea
    Cell Death Differ 14:103-15. 2007
    beta-Amyloid precursor protein binding protein 1 (APP-BP1) was previously identified based on its binding to the carboxyl terminal of beta-amyloid precursor protein...
  64. ncbi Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity
    Patricia Rusu
    Zentrum für Molekulare Biologie ZMBH, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Eur J Neurosci 25:1079-86. 2007
    ..tangles and extracellular plaques, which consist mainly of beta-amyloid derived from the beta-amyloid precursor protein (APP)...
  65. pmc Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening
    Masaki Sone
    Medical Top Track Program, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 4:e4466. 2009
    ..Drosophila Amyloid precursor protein like (APPL) and Hikaru genki (HIG) are examples of proteins that show differential subcellular localization ..
  66. pmc Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila
    Weihuan Cao
    Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA
    Genetics 178:1457-71. 2008
    ..Although a lot is known about the pathology of AD and the role of beta-amyloid (Abeta) peptides, the complete network of interactions regulating Abeta metabolism and toxicity still eludes us...

Research Grants1

  1. GENETIC AND IMMUNOLOGIC ANALYSIS OF MICROTUBULE PROTEINS
    Lawrence Goldstein; Fiscal Year: 2006
    ..We will determine the composition and role in kinesin-I transport of components of the syd/JIP-3 and the amyloid precursor protein complexes.