aPKC

Summary

Gene Symbol: aPKC
Description: atypical protein kinase C
Alias: CG10261, CG30475, CG42783, DaPKC, Dmel\CG42783, Dmel_CG10261, Dmel_CG30475, PKCl, PKCzeta, a-PKC, aPKC-zeta, aPKCzeta, aPkc, alphaPKCzeta, apkc, daPKC, dapkc, l(2)k06403, pkc-3, psu, CG42783 gene product from transcript CG42783-RA, CG42783-PA, CG42783-PB, CG42783-PC, CG42783-PD, CG42783-PE, CG42783-PF, CG42783-PG, CG42783-PI, CG42783-PJ, CG42783-PK, CG42783-PL, CG42783-PM, aPKC-PA, aPKC-PB, aPKC-PC, aPKC-PD, aPKC-PE, aPKC-PF, aPKC-PG, aPKC-PI, aPKC-PJ, aPKC-PK, aPKC-PL, aPKC-PM, atypical PKC, atypical protein kinase, atypical-Protein kinase C, pschur
Species: fruit fly

Top Publications

  1. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
  2. doi Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells
    Annalisa Letizia
    Institut de Biologia Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, Baldiri Reixac, 10 12, 08028 Barcelona, Spain
    J Cell Sci 124:240-51. 2011
  3. ncbi Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila
    Isabelle E Bécam
    Institut Jacques Monod, CNRS, Universités Paris 6 et 7, 2, place Jussieu, F 75251 Paris Cedex 05, France
    Nat Cell Biol 7:510-6. 2005
  4. pmc The Hippo pathway regulates apical-domain size independently of its growth-control function
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:2360-70. 2009
  5. doi Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids
    Michael P Krahn
    Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain CMPB, Georg August Universitat Gottingen, Justus von Liebig Weg 11, Gottingen, Germany
    Curr Biol 20:636-42. 2010
  6. pmc Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Genes Dev 20:3464-74. 2006
  7. pmc aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb
    Christian A Smith
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    EMBO J 26:468-80. 2007
  8. ncbi The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis
    Ying Wang
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrasse 17, D 50931 Köln, Germany
    Curr Biol 17:1349-55. 2007
  9. pmc Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
    Frederik Wirtz-Peitz
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell 135:161-73. 2008
  10. pmc Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions
    Rita Sousa-Nunes
    Department of Biological Sciences, Temasek Life Sciences Laboratory, National University of Singapore, Singapore
    Genes Dev 23:359-72. 2009

Research Grants

  1. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2001
  2. MOLECULAR GENETICS OF PHOTOTRANSDUCTION
    Bih Hwa Shieh; Fiscal Year: 2006
  3. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
  4. RNA and the Etiology of Disease
    Joel Richter; Fiscal Year: 2008
  5. Mechanisms of Mitotic Recombination
    JEFF JOSEPH SEKELSKY; Fiscal Year: 2010
  6. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
  7. Tight Junction Proteins and Epithelial Polarity
    Benjamin Margolis; Fiscal Year: 2009
  8. Novel Cilia Trafficking Mechanisms
    BENJAMIN L MARGOLIS; Fiscal Year: 2010
  9. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications128 found, 100 shown here

  1. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
    ..AurA suppresses tumor formation by asymmetrically localizing atypical protein kinase C (aPKC), an NB proliferation factor...
  2. doi Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells
    Annalisa Letizia
    Institut de Biologia Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, Baldiri Reixac, 10 12, 08028 Barcelona, Spain
    J Cell Sci 124:240-51. 2011
    ..This hypothesis is supported by the phenotype of lethal giant larvae (lgl); crb double mutants. These results unveil a link between Crb and the organisation of the actin cytoskeleton during morphogenesis...
  3. ncbi Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila
    Isabelle E Bécam
    Institut Jacques Monod, CNRS, Universités Paris 6 et 7, 2, place Jussieu, F 75251 Paris Cedex 05, France
    Nat Cell Biol 7:510-6. 2005
    ..Surprisingly, this function of talin is independent of integrins. These results uncover a new role for talin in regulating cadherin-mediated cell adhesion...
  4. pmc The Hippo pathway regulates apical-domain size independently of its growth-control function
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:2360-70. 2009
    ..In the wing imaginal disc epithelium, we observe increased staining for members of the apical polarity complexes aPKC and Crumbs as well as adherens junction components when Hippo activity is compromised, while basolateral markers ..
  5. doi Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids
    Michael P Krahn
    Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain CMPB, Georg August Universitat Gottingen, Justus von Liebig Weg 11, Gottingen, Germany
    Curr Biol 20:636-42. 2010
    ..The PAR-3/PAR-6/atypical protein kinase C (aPKC) complex is the first to become asymmetrically localized, and it controls the localization of ..
  6. pmc Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Genes Dev 20:3464-74. 2006
    ..This phenotype is due to two independent neuroblast defects: abnormal atypical protein kinase C (aPKC)/Numb cortical polarity and failure to align the mitotic spindle with the cortical polarity axis...
  7. pmc aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb
    Christian A Smith
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    EMBO J 26:468-80. 2007
    In Drosophila, the partition defective (Par) complex containing Par3, Par6 and atypical protein kinase C (aPKC) directs the polarized distribution and unequal segregation of the cell fate determinant Numb during asymmetric cell divisions...
  8. ncbi The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis
    Ying Wang
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrasse 17, D 50931 Köln, Germany
    Curr Biol 17:1349-55. 2007
    ..Myosin is activated at the apical cortex by localized Rho kinase and inhibited at the basolateral cortex by PP1beta9C. In addition, our data indicate that active myosin is apically anchored by the Baz/Par-6/aPKC complex.
  9. pmc Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
    Frederik Wirtz-Peitz
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell 135:161-73. 2008
    ..Aurora-A phosphorylates Par-6, a regulatory subunit of atypical protein kinase C (aPKC)...
  10. pmc Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions
    Rita Sousa-Nunes
    Department of Biological Sciences, Temasek Life Sciences Laboratory, National University of Singapore, Singapore
    Genes Dev 23:359-72. 2009
    ..Our findings suggest that Flfl may target PP4 to the MIra protein complex to facilitate dephosphorylation step(s) crucial for its cortical association/asymmetric localization...
  11. pmc The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth
    Fisun Hamaratoglu
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 122:2351-9. 2009
    ..double mutant imaginal disc cells have significantly increased levels of apical membrane determinants, such as Crb, aPKC and Patj...
  12. pmc Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium
    Robert P Simone
    University of Pennsylvania Medical School, Department of Cell and Developmental Biology, 421 Curie Boulevard, Philadelphia, PA 19104 6048, USA
    Development 137:1385-94. 2010
    ..Indeed, depletion of Myosin II or dlg disrupts these processes. These results show that tight spatial regulation of actomyosin contractility is required to produce this high-energy arrangement of cells...
  13. ncbi Multicellular rosette formation links planar cell polarity to tissue morphogenesis
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Cell 11:459-70. 2006
    ..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis...
  14. ncbi The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Cell Sci 120:3099-110. 2007
    ..These results suggest that epithelial polarity in the Drosophila embryo is actively maintained by exocyst-dependent apical localization of the Crumbs transmembrane protein...
  15. pmc Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye
    Nicola A Grzeschik
    Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Dev Biol 311:106-23. 2007
    ....
  16. doi Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability
    Marios Georgiou
    MRC Laboratory for Molecular Cell Biology, Division of Life Sciences, University College London, Gower Street, London WC1E 6BT, UK
    Curr Biol 18:1631-8. 2008
    ....
  17. pmc Functional interactions between the erupted/tsg101 growth suppressor gene and the DaPKC and rbf1 genes in Drosophila imaginal disc tumors
    M Melissa Gilbert
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 4:e7039. 2009
    ..Excess cell division is postulated to be a primary cause of these 'neoplastic' phenotypes, but the autonomous effect of these mutations on cell cycle control has not been examined...
  18. ncbi Asymmetric cell division: fly neuroblast meets worm zygote
    C Q Doe
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Curr Opin Cell Biol 13:68-75. 2001
    ..Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote...
  19. ncbi Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster
    Eric A Drier
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 5:316-24. 2002
    ..PKMzeta is a truncated, persistently active isoform of atypical protein kinase C-zeta (aPKCzeta), which lacks the N-terminal pseudosubstrate regulatory domain...
  20. ncbi Asymmetric division of Drosophila neural progenitors
    William Chia
    MRC Centre for Developmental Neurobiology, King s College London, 4th Floor, New Hunts House, Guy s Hospital Campus, London, UK
    Curr Opin Genet Dev 12:459-64. 2002
    ..Recent findings also suggest possible mechanisms by which the processes of cell-cycle progression, neuronal lineage development and asymmetric divisions may be integrated...
  21. ncbi Composition and formation of intercellular junctions in epithelial cells
    Elisabeth Knust
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Science 298:1955-9. 2002
    ..Comparisons between fly, worm, and vertebrate epithelia reveal marked similarities with respect to the molecules used, and pronounced differences in the organization of the junctions themselves...
  22. ncbi Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia
    Salim Abdelilah-Seyfried
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
    Development 130:1927-35. 2003
    Drosophila Bazooka and atypical protein kinase C are essential for epithelial polarity and adhesion...
  23. ncbi Apicobasal polarization: epithelial form and function
    Matthew C Gibson
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA
    Curr Opin Cell Biol 15:747-52. 2003
    ..Recent findings show that segregation of ligand and receptor with one on each side of this barrier can be a crucial regulator of cell-cell signaling events...
  24. pmc Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia
    Melissa M Rolls
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA
    J Cell Biol 163:1089-98. 2003
    ..In many organisms, cell polarity is regulated by the atypical protein kinase C (aPKC), Bazooka (Baz/Par3), and Par6 proteins...
  25. ncbi Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis
    Andrea Hutterer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Dev Cell 6:845-54. 2004
    ..We show here that polarity is established shortly after cellularization when Par-6 and the atypical protein kinase C concentrate on the apical side of the newly formed cells...
  26. ncbi Endocytic control of epithelial polarity and proliferation in Drosophila
    Han Lu
    Department of Molecular and Cell Biology, University of California Berkeley, 142 LSA 3200 Berkeley, CA 94720 3200 USA
    Nat Cell Biol 7:1232-9. 2005
    ..Our findings reveal a critical and specific role for endocytic traffic in the control of both apico-basal polarity and cell proliferation...
  27. ncbi Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, Oregon 97403, USA
    Nature 439:594-8. 2006
    ..The lgl pins neuroblasts show ectopic cortical localization of atypical protein kinase C (aPKC), and a decrease in aPKC expression reduces neuroblast numbers, suggesting that aPKC promotes ..
  28. ncbi Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts
    Sarah E Siegrist
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Development 133:529-36. 2006
    ..This ensures the proper coordination between neuroblast cell polarity and CNS tissue polarity...
  29. pmc Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila
    Ai Guo Tian
    Department of Biological Science, Florida State University, Tallahassee, FL 32306 4370, USA
    Development 135:463-71. 2008
    ..Here, we show important roles for the tumor suppressor Lethal (2) giant larvae (Lgl) and atypical protein kinase C (aPKC) in regulating microtubule polarity and setting up the AP axis of the oocyte...
  30. doi Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis
    Andrea Leibfried
    Institut Curie, Centre National de la Recherche, UMR 144, Equipe Polarité Cellulaire chez la Drosophile, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Biol 18:1639-48. 2008
    ..A mechanism regulating E-Cadherin (E-Cad) exocytosis to the AJs has implicated proteins of the exocyst complex, but mechanisms regulating E-Cad endocytosis from the AJs remain less well understood...
  31. pmc Crumbs stabilises epithelial polarity during tissue remodelling
    Kyra Campbell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    J Cell Sci 122:2604-12. 2009
    ....
  32. pmc Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    J Cell Biol 150:1361-74. 2000
    ..This study is the first functional analysis of an atypical protein kinase C isoform using a loss-of-function allele in a genetically tractable organism.
  33. ncbi Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity
    S Ohno
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9, Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Curr Opin Cell Biol 13:641-8. 2001
    Two PDZ-domain-containing adapter-like proteins, PAR-3 and PAR-6, and a protein kinase, atypical protein kinase C (PKC), cooperate together to establish cell polarity in a variety of biological contexts...
  34. pmc Bazooka and atypical protein kinase C are required to regulate oocyte differentiation in the Drosophila ovary
    D N Cox
    Howard Hughes Medical Institute, Department of Physiology, University of California, 533 Parnassus Avenue, Room U426, Box 0725, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 98:14475-80. 2001
    ..diverse cell types by means of an evolutionarily conserved protein complex including PAR-3, PAR-6, and atypical protein kinase C (aPKC)...
  35. ncbi Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts
    Y Hong
    Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, California 94143 0725, USA
    Nature 414:634-8. 2001
    ..However, for the subset of ectodermal cells that delaminate and form neuroblasts, their polarity requires the function of Bazooka, but not of Stardust or Crumbs...
  36. ncbi Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity
    A Bachmann
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
    Nature 414:638-43. 2001
    ..The Stardust proteins represent versatile candidates as structural and possibly regulatory constituents of the SAC, a crucial element in the control of epithelial cell polarity...
  37. ncbi Control of cell polarity and mitotic spindle positioning in animal cells
    Julie Ahringer
    Wellcome Trust Cancer Research UK Institute, Tennis Court Road, Cambridge CB2 1QR, UK
    Curr Opin Cell Biol 15:73-81. 2003
    ..Microtubules and conserved PAR proteins are essential mediators of cell polarity, and mitotic spindle positioning depends on heterotrimeric G protein signalling and the microtubule motor protein dynein...
  38. ncbi Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions
    Yu Cai
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    Cell 112:51-62. 2003
    ..show that mitotic spindle geometry and unequal daughter cell size are controlled by two parallel pathways (Bazooka/DaPKC and Pins/G alpha i) within the apical complex...
  39. ncbi A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
    Sophie G Martin
    The Wellcome Trust Cancer Research UK
    Nature 421:379-84. 2003
    ..Thus, Drosophila and human LKB1 may be functional homologues, suggesting that loss of cell polarity may contribute to tumour formation in individuals with Peutz-Jeghers syndrome...
  40. ncbi Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
    Roger Albertson
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon 1254, Eugene, OR 97403, USA
    Nat Cell Biol 5:166-70. 2003
    ..We conclude that Dlg/Scrib/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts...
  41. ncbi The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
    Jörg Betschinger
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nature 422:326-30. 2003
    ..Phosphorylation by Drosophila atypical protein kinase C (aPKC), a member of the Par protein complex, releases Lgl from its association with membranes and the ..
  42. ncbi The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium
    Hélène Doerflinger
    The Wellcome Trust Cancer Research UK Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Development 130:3965-75. 2003
    ..Although the direct targets of PAR-1 are unknown, we suggest that it functions by regulating the plus ends, possibly by capping them at the basal cortex...
  43. ncbi Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila
    Sang Chul Nam
    Department of Molecular and Cellular Biology, Baylor College of Medicine, TX 77030, USA
    Development 130:4363-72. 2003
    ..Crb, Stardust (Sdt) and Discs-lost (Dlt) colocalizes with another protein complex containing Par-6 and atypical protein kinase C (aPKC) in the rhabdomere stalk of photoreceptors...
  44. ncbi Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells
    Richard Benton
    The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, CB2 1QR Cambridge, United Kingdom
    Cell 115:691-704. 2003
    ..This inhibits formation of the Bazooka/PAR-6/aPKC complex by blocking Bazooka oligomerization and binding to aPKC...
  45. pmc New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants
    Catalina Ruiz-Canada
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Neuron 42:567-80. 2004
    The Baz/Par-3-Par-6-aPKC complex is an evolutionarily conserved cassette critical for the development of polarity in epithelial cells, neuroblasts, and oocytes...
  46. ncbi LKB1 tumor suppressor protein: PARtaker in cell polarity
    Annette F Baas
    Hubrecht Laboratory, Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Trends Cell Biol 14:312-9. 2004
    ..In this article, we summarize the findings regarding LKB1 over the past six years. In addition, we discuss LKB1 in polarity in the context of both the other PAR proteins and its tumor suppressive activities...
  47. pmc DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila
    Sol Sotillos
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Univerisidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Cell Biol 166:549-57. 2004
    ..We show, by overexpression of a kinase-dead Drosophila atypical PKC (DaPKC), the requirement for the kinase activity of DaPKC to maintain the position of apical determinants and ..
  48. ncbi Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates
    Jörg Betschinger
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Curr Biol 14:R674-85. 2004
    ..Here, we outline the steps and factors that are involved in this process in Drosophila and C. elegans and discuss their potential conservation in vertebrates...
  49. ncbi Requirement for Par-6 and Bazooka in Drosophila border cell migration
    Elaine M Pinheiro
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Development 131:5243-51. 2004
    ..Here, we report the localization of several apical epithelial proteins, Par-6, Par-3/Bazooka and aPKC, during border cell migration in the Drosophila ovary...
  50. ncbi Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila
    Melissa M Rolls
    Institute of Neuroscience and Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Nat Neurosci 7:1293-5. 2004
    Par-3/Baz, Par-6, and aPKC are evolutionarily conserved regulators of cell polarity, and overexpression experiments implicate them as axon determinants in vertebrate hippocampal neurons...
  51. ncbi Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling
    Walter von Stein
    Abteilung Stammzellbiologie, CMPB, Georg August Universitat Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Development 132:1675-86. 2005
    Cell polarity in Drosophila epithelia, oocytes and neuroblasts is controlled by the evolutionarily conserved PAR/aPKC complex, which consists of the serine-threonine protein kinase aPKC and the PDZ-domain proteins Bazooka (Baz) and PAR-6...
  52. ncbi The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye
    Alexandre Djiane
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell 121:621-31. 2005
    ..We demonstrate that dPatj binds the cytoplasmic tail of Fz1 and propose that it recruits aPKC, which in turn phosphorylates and inhibits Fz1...
  53. pmc The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 170:813-23. 2005
    ..Surprisingly, we found that Baz localizes to an apical domain below its typical binding partners atypical protein kinase C (aPKC) and partitioning defective (PAR)-6 as the Drosophila epithelium first forms...
  54. ncbi Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
    Emmanuel Caussinus
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Genet 37:1125-9. 2005
    ....
  55. ncbi Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins
    Hongyan Wang
    Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604
    Nat Cell Biol 7:1091-8. 2005
    ..In addition, Gbetagamma acts to restrict Galphai (and GoLoco proteins) to the apical cortex, where Galphai (and Pins) can mediate asymmetric spindle geometry...
  56. ncbi Apicobasal polarity complexes
    Ben Margolis
    Department of Internal Medicine and Biological Chemistry, University of Michigan, Medical School, Ann Arbor, MI 48109, USA
    J Cell Sci 118:5157-9. 2005
  57. ncbi Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila Crumbs for the PDZ domains of Stardust and DmPar-6
    Ozlem Kempkens
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, D 40225 Dusseldorf, Germany
    Eur J Cell Biol 85:753-67. 2006
    ..in cell cultures and in the Drosophila embryo show that the cytoplasmic domain of Crumbs can recruit DmPar-6 and DaPKC to the plasma membrane...
  58. ncbi aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia
    D Grifoni
    Dipartimento di Biologia Evoluzionistica Sperimentale, Alma Mater Studiorum, Via Selmi 3, 40126 Bologna, Italy
    Oncogene 26:5960-5. 2007
    b>Atypical protein kinase C (aPKC) and Lethal giant larvae (Lgl) regulate apical-basal polarity in Drosophila and mammalian epithelia...
  59. pmc LKB1 and AMPK maintain epithelial cell polarity under energetic stress
    Vincent Mirouse
    The Gurdon Institute, Department of Genetics, University of Cambridge, Cambridge, England, UK
    J Cell Biol 177:387-92. 2007
    ..Thus, LKB1 signals through AMPK to coordinate epithelial polarity and proliferation with cellular energy status, and this might underlie the tumor suppressor function of LKB1...
  60. ncbi Energy-dependent regulation of cell structure by AMP-activated protein kinase
    Jun Hee Lee
    National Creative Research Initiatives Center for Cell Growth Regulation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong gu, Taejon 305 701, Korea
    Nature 447:1017-20. 2007
    ..Taken together, our results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures...
  61. pmc aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Dev Cell 12:727-38. 2007
    ..We show that atypical Protein Kinase C (aPKC) is required for symmetric AJ positioning during Drosophila embryogenesis...
  62. ncbi The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division
    Silvia Bonaccorsi
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, P le A Moro 5, 00185 Roma, Italy
    Development 134:2183-93. 2007
    ..of larval neuroblasts (NBs); they suppress unequal cytokinesis, abrogate proper localization of Bazooka, Par-6, DaPKC and Miranda, but affect neither Pins/Galphai localization nor spindle rotation...
  63. pmc Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC
    Scott X Atwood
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    J Cell Sci 120:3200-6. 2007
    Cdc42 recruits Par-6-aPKC to establish cell polarity from worms to mammals...
  64. pmc A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation
    Laurent Menut
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Genetics 177:1667-77. 2007
    ..The isolation of additional loci that affect hyperplastic as well as neoplastic growth indicates the utility of this screening strategy for studying epithelial growth control...
  65. ncbi Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2 3PX, United Kingdom
    Curr Biol 17:1864-70. 2007
    ..The PCP members of the SWH network are not involved in this process, indicating that signaling upstream of Hpo varies according to developmental context...
  66. pmc Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity
    Zhouhua Li
    Temasek Lifesciences Laboratory, National University of Singapore, Singapore 117604
    J Cell Biol 180:31-8. 2008
    ....
  67. pmc Dynein regulates epithelial polarity and the apical localization of stardust A mRNA
    Sally Horne-Badovinac
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e8. 2008
    ..Moreover, we introduce a unique mechanism in which alternative splicing of a coding exon is used to control mRNA localization during development...
  68. pmc The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 14:535-46. 2008
    ..Our data describe a transit-amplifying lineage in the Drosophila nervous system and suggest that different vulnerabilities in intermediate cell types can affect the outcome of tumor suppressor loss in stem cell lineages...
  69. doi Rho GTPase controls invagination and cohesive migration of the Drosophila salivary gland through Crumbs and Rho-kinase
    Na Xu
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Dev Biol 321:88-100. 2008
    ..of zygotic function of Rho1 results in the selective loss of the apical proteins, Crumbs (Crb), Drosophila atypical PKC and Stardust during gland invagination and that this is partially due to reduced crb RNA levels and apical ..
  70. pmc PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells
    Jocelyn A McDonald
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Curr Biol 18:1659-67. 2008
    ....
  71. pmc Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]
    Felix A Grusche
    European Molecular Biology Laboratory, Heidelberg, Germany
    BMC Dev Biol 9:14. 2009
    ..How epithelial cells adopt their particular polarised forms is poorly understood. In a screen for genes regulating epithelial morphology in Drosophila, we identified sds22, a conserved gene previously characterised in yeast...
  72. pmc aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division
    Scott X Atwood
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    Curr Biol 19:723-9. 2009
    ..b>Atypical protein kinase C (aPKC) is an evolutionarily conserved regulator of cell polarity...
  73. doi GSK3beta affects apical-basal polarity and cell-cell adhesion by regulating aPKC levels
    Pamela F Colosimo
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Dev Dyn 239:115-25. 2010
    ..We show that loss of the Wnt signaling component GSK3 beta results in increased levels of aPKC and leads to defects in apical-basal polarity...
  74. doi PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts
    Michael P Krahn
    Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain, Georg August Universitat Gottingen, Gottingen, Germany
    Dev Cell 16:901-8. 2009
    ..Phosphorylation of Baz by PAR-1 and aPKC is required for its function in epithelia, but little is known about the dephosphorylation mechanisms that ..
  75. doi Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins
    Patrick Laprise
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Nature 459:1141-5. 2009
    ..We also find that the mammalian Yrt orthologue EPB41L5 (also known as YMO1 and Limulus) is required for lateral membrane formation, indicating a conserved function of Yrt proteins in epithelial polarity...
  76. pmc Epithelial polarity: interactions between junctions and apical-basal machinery
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genetics 183:897-904. 2009
    ..We propose a model where zw3 regulates protein levels of apical and adhesion components and suggest that a reciprocal interaction between junctions and polarity modules functions to maintain stable apical and basolateral domains...
  77. pmc Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs
    Gregory R Leong
    Peter MacCallum Cancer Centre, Victoria, Australia
    BMC Biol 7:62. 2009
    ..Increasing evidence also implicates the loss of human Scrib in cancer. In this report, we investigate how loss of Scrib promotes epithelial tumourigenesis in Drosophila, both alone and in cooperation with oncogenic mutations...
  78. pmc Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension
    Stephen J Warner
    Department of Medicine, Washington University, St Louis, MO 63110, USA
    J Cell Biol 187:119-33. 2009
    ..Cdc42 localizes Par6-atypical protein kinase C (aPKC) to AJs, where this complex limits Rho1 activity and thus actomyosin contractility, independent of ..
  79. doi Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions
    Marios Georgiou
    MRC Laboratory of Molecular Cell Biology, UCL, London, WC1E 6BT, UK
    J Cell Sci 123:1089-98. 2010
    ..Bazooka/Par3 acts upstream of the RacGEF Sif/TIAM1 to limit filopodia to the basal domain, whereas Cdc42, aPKC and Par6 are required for normal protrusion morphology and dynamics...
  80. doi Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms
    Nicola A Grzeschik
    Cell Cycle and Development, Peter MacCallum Cancer Centre, Victoria, Australia
    Curr Biol 20:573-81. 2010
    ..Ectopic expression of the apical polarity regulators atypical protein kinase C (aPKC) and Crumbs also leads to increased cell proliferation and/or survival...
  81. pmc A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium
    Wei Shao
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e9938. 2010
    ..We sought to identify additional proteins that function with Baz to regulate epithelial structure in the Drosophila embryo...
  82. pmc aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells
    Eurico Morais-de-Sá
    The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 141:509-23. 2010
    Bazooka (PAR-3), PAR-6, and aPKC form a complex that plays a key role in the polarization of many cell types. In epithelial cells, however, Bazooka localizes below PAR-6 and aPKC at the apical/lateral junction...
  83. doi Crumbs/DaPKC-dependent apical exclusion of Bazooka promotes photoreceptor polarity remodeling
    Rhian F Walther
    Medical Research Council MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, WC1E 6BT London, UK
    Curr Biol 20:1065-74. 2010
    ..This depends on the intertwined function of Bazooka (Baz), Par6-DaPKC, and the Crumbs (Crb)-Stardust (Sdt)-PATJ complex...
  84. doi Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis
    Nicole A Kaplan
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 423, New York, NY 10021, USA
    J Cell Sci 123:3157-65. 2010
    ..We conclude that apical-basal proteins, used to establish polarity within a cell, can be independently co-opted to function in epithelial morphogenesis...
  85. pmc Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis
    Anthony M Brumby
    Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Genetics 188:105-25. 2011
    ..are important for the cooperation of RhoGEF2 or Pbl overexpression and of mutants in polarity regulators, Dlg and aPKC, with Ras(ACT) in the whole-tissue context...
  86. pmc A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension
    Jessica K Sawyer
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Biol Cell 22:2491-508. 2011
    ..polarity and dramatically increases planar polarity of the apical polarity proteins Bazooka/Par3 and atypical protein kinase C. Changes in Bazooka localization parallel retraction of the actomyosin network...
  87. pmc A novel function for the PAR complex in subcellular morphogenesis of tracheal terminal cells in Drosophila melanogaster
    Tiffani A Jones
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
    Genetics 189:153-64. 2011
    ..This complex, composed of the proteins Par-6, Bazooka (Par-3), aPKC, and Cdc42, is best known for roles in asymmetric cell division and apical/basal polarity...
  88. pmc The Drosophila CPEB protein Orb2 has a novel expression pattern and is important for asymmetric cell division and nervous system function
    Nathaniel Hafer
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Genetics 189:907-21. 2011
    ..We also show that orb2 funtions in asymmetric division of stem cells and precursor cells during the development of the embryonic nervous system and mesoderm...
  89. doi Positive feedback and mutual antagonism combine to polarize Crumbs in the Drosophila follicle cell epithelium
    Georgina C Fletcher
    Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Curr Biol 22:1116-22. 2012
    ..ovarian follicle cell epithelium, apical membranes are specified by Crumbs (Crb), Stardust (Sdt), and the aPKC-Par6-cdc42 complex...
  90. pmc Drosophila Patj plays a supporting role in apical-basal polarity but is essential for viability
    Wenke Zhou
    Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Development 139:2891-6. 2012
    ..In addition, our results confirm that dPatj possesses an as yet unidentified function that is essential for pupal development...
  91. pmc Discs large links spindle orientation to apical-basal polarity in Drosophila epithelia
    Dan T Bergstralh
    The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Curr Biol 23:1707-12. 2013
    ..Previous work has implicated the apical polarity factor aPKC, the junctional protein APC2, and basal integrins in epithelial spindle orientation, but the underlying mechanisms ..
  92. pmc Epithelial polarity and spindle orientation: intersecting pathways
    Dan T Bergstralh
    The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Philos Trans R Soc Lond B Biol Sci 368:20130291. 2013
    ..In this review, we examine several factors implicated in both processes, namely Canoe, Bazooka, aPKC and Discs large, and consider the implications of this work on how the spindle is oriented during epithelial cell ..
  93. ncbi Cell polarity: the PARty expands
    C Q Doe
    Institute of Molecular Biology and the Institute of Neuroscience, HHMI, University of Oregon, Eugene, Oregon 97403, USA
    Nat Cell Biol 3:E7-9. 2001
    ..This common cell-polarity mechanism is used in cell-specific ways, as highlighted by the recent finding that at least two different types of asymmetric division are observed in Drosophila neural precursors...
  94. ncbi Neuronal polarity in CNS development
    David J Solecki
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 20:2639-47. 2006
    ....
  95. pmc Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis
    Kathryn P Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 183:1129-43. 2008
    ..This study reveals functional interactions between apical polarity proteins and endocytosis that are critical for stabilizing dynamic basolateral AJs...
  96. pmc The ups and downs of life in an epithelium
    H Kramer
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Cell Biol 151:F15-8. 2000
  97. ncbi Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells
    Emmanuelle Médina
    NMDA IBDM, UMR 6156, Campus de Luminy, Universite de la Mediterranee, Case 907, 13288 Marseille Cedex 09, France
    Biol Cell 94:305-13. 2002
    ..Finding an answer to these questions will help to find new therapies for Retinitis pigmentosa and other retina degeneration in which CRB1, the human homologue of crb, has been involved...
  98. ncbi Myosins motor Miranda
    Daniel P Kiehart
    Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University, Durham, NC 27708, USA
    Mol Cell 12:1346-7. 2003
    ..New evidence shows that myosin motors drive the spatial segregation of cell fate determinants during asymmetric cell division. How they do so remains a mystery...
  99. ncbi Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins
    Bernhard Hampoelz
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Nat Cell Biol 7:1099-105. 2005
    ..Our results indicate a model in which both receptor-dependent and receptor-independent G-protein functions are executed at the plasma membrane and require the Ric-8 protein...
  100. ncbi Playing ping pong with pins: cortical and microtubule-induced polarity
    Julie Ahringer
    The Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom
    Cell 123:1184-6. 2005
    ..In this issue of Cell, it is turned around and shown that the transfer of polarity information between the cortex and the spindle is not just one way. In Drosophila neuroblasts, the spindle also has polarizing activity on the cortex...
  101. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
    ..Similar defects are seen in lethal giant larvae (lgl) mutants where Brat and Prospero are not asymmetric. We have identified a molecular mechanism that may control self-renewal and prevent tumor formation in other stem cells as well...

Research Grants10

  1. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2001
    ..Finally, an mRNA that is deadenylated and stored in a dormant form in mouse oocytes undergoes prior CPE-mediated deadenylation. The possible role of mCPEB in the process will be assessed. ..
  2. MOLECULAR GENETICS OF PHOTOTRANSDUCTION
    Bih Hwa Shieh; Fiscal Year: 2006
    ..Un-regulated signaling may lead to hyperactivity or degeneration of neurons, which has been implicated in mans pathophysiological conditions such as epilepsy and neurodegenerative diseases. ..
  3. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
    ..The cross-disciplinary nature of this meeting will be attractive to molecular, cellular, developmental, and neurobiological scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
  4. RNA and the Etiology of Disease
    Joel Richter; Fiscal Year: 2008
    ..The meeting is cross-disciplinary in its approach, which is essential for combating human disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  5. Mechanisms of Mitotic Recombination
    JEFF JOSEPH SEKELSKY; Fiscal Year: 2010
    ..These studies will enhance our understanding of mechanisms of mitotic crossing over and the role that the important tumor suppressor protein BLM plays in preventing mitotic crossing over. ..
  6. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  7. Tight Junction Proteins and Epithelial Polarity
    Benjamin Margolis; Fiscal Year: 2009
    ..that PALS1 directly interacts with a common polarity cassette consisting of three proteins Par3/Par6/atypical Protein Kinase C. The goal of our research is to understand how PALS1 and PATJ control the initial steps in epithelial ..
  8. Novel Cilia Trafficking Mechanisms
    BENJAMIN L MARGOLIS; Fiscal Year: 2010
    ..Cystic diseases of the kidney, where the normal kidney is replaced by non-functioning fluid filled cysts, are a major cause of kidney failure. ..
  9. Functional Anatomy of Learning and Memory in Drosophila
    JOSHUA DUBNAU; Fiscal Year: 2008
    ..As a result, an understanding of the "logic" of how information is processed in relatively simple nervous systems can greatly inform future investigations of human cognition. ..